{
    "1MfmuiD3": {
        "id": "1MfmuiD3",
        "title": "SymmetriSense: Enabling Near-Surface Interactivity on Glossy Surfaces using a Single Commodity Smartphone.",
        "abstract": "Driven to create intuitive computing interfaces throughout our everyday space, various state-of-the-art technologies have been proposed for near-surface localization of a useru0027s finger input such as hover or touch. However, these works require specialized hardware not commonly available, limiting the adoption of such technologies. We present SymmetriSense, a technology enabling near-surface 3-dimensional fingertip localization above arbitrary glossy surfaces using a single commodity camera device such as a smartphone. SymmetriSense addresses the localization challenges in using a single regular camera by a novel technique utilizing the principle of reflection symmetry and the fingertipu0027s natural reflection casted upon surfaces like mirrors, granite countertops, or televisions. SymmetriSense achieves typical accuracies at sub-centimeter levels in our localization tests with dozens of volunteers and remains accurate under various environmental conditions. We hope SymmetriSense provides a technical foundation on which various everyday near-surface interactivity can be designed.",
        "keywords": "",
        "authors": [
            {
                "name": "Chungkuk Yoo",
                "org": ""
            },
            {
                "name": "Inseok Hwang",
                "org": ""
            },
            {
                "name": "Eric Rozner",
                "org": ""
            },
            {
                "name": "Yu Gu",
                "org": ""
            },
            {
                "name": "Robert F. Dickerson",
                "org": ""
            }
        ],
        "venue": "CHI",
        "year": 2016
    },
    "d7YylBxB": {
        "id": "d7YylBxB",
        "title": "Demo: Mobile Platform for Interactive Applications on Everyday Surfaces using a Single Commodity Smartphone.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Chungkuk Yoo",
                "org": ""
            },
            {
                "name": "Inseok Hwang",
                "org": ""
            },
            {
                "name": "Eric Rozner",
                "org": ""
            },
            {
                "name": "Yu Gu",
                "org": ""
            },
            {
                "name": "Robert F. Dickerson",
                "org": ""
            }
        ],
        "venue": "MobiSys (Companion Volume)",
        "year": 2016
    },
    "Zf1zyQML": {
        "id": "Zf1zyQML",
        "title": "A novel photoanode with high flexibility for fiber-shaped dye sensitized solar cells",
        "abstract": "A completely flexible fiber-shaped dye sensitized solar cell has been truly realized for the first time, due to a novel photoanode with a TiO2 micron-cone-nanowire array structure prepared by a simple two-step process. The TiO2 micron-cone array, made using an electrochemical method, is used as a frame for a novel photoanode, with its roots sinking deep down into a Ti wire substrate. The TiO2 nanowire array is coated onto the TiO2 micron-cone surface by a hydrothermal reaction to form a dye-adsorption layer to the enhance power conversion efficiency of the novel device. With a high dye-adsorption capacity and strong combination between the TiO2 micron-cone and Ti substrate, the minimum bending radius of the photoanode could reach 0.45 mm, and 96.6% retention of the initial conversion efficiency was obtained after bending 100 times.",
        "keywords": "",
        "authors": [
            {
                "name": "Guicheng Liu",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District,Beijing 100083,P.R. China"
            },
            {
                "name": "Guicheng Liu",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District,Beijing 100083,P.R. China"
            },
            {
                "name": "Xue Gao",
                "org": ""
            },
            {
                "name": "Hui Wang",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District,Beijing 100083,P.R. China"
            },
            {
                "name": "A-Young Kim",
                "org": ""
            },
            {
                "name": "A-Young Kim",
                "org": ""
            },
            {
                "name": "Zhenxuan Zhao",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District,Beijing 100083,P.R. China"
            },
            {
                "name": "Joong Kee Lee",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14 gil 5, Seongbuk-gu,Seoul 02792,Republic of Korea"
            },
            {
                "name": "Dechun Zou",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District,Beijing 100083,P.R. China"
            },
            {
                "name": "Dechun Zou",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District,Beijing 100083,P.R. China"
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2016
    },
    "cLUf7Ryd": {
        "id": "cLUf7Ryd",
        "title": "An 8.07% efficient fiber dye-sensitized solar cell based on a TiO 2 micron-core array and multilayer structure photoanode",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guicheng liu",
                "org": ""
            },
            {
                "name": "ming peng",
                "org": ""
            },
            {
                "name": "weixing song",
                "org": ""
            },
            {
                "name": "hui wang",
                "org": ""
            },
            {
                "name": "dechun zou",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "H65lNo1X": {
        "id": "H65lNo1X",
        "title": "Hierarchically structured photoanode with enhanced charge collection and light harvesting abilities for fiber-shaped dye-sensitized solar cells",
        "abstract": "The performances of fiber dye-sensitized solar cells (FDSSCs), in terms of charge collection efficiency, light-harvesting ability, and structural stability, are improved through a novel hierarchically structured photoanode based on a Ti microridge/nanorod-modified wire substrate. The microridge made of several Ti micropits is inserted into TiO2 layer to shorten the photoelectron transport distance from the original place in the TiO2 layer to substrate and to increase the electron transport rate. The Ti micropits are used as light-gathering centers to collect the reflected light. Meanwhile, the Ti nanorods are evenly distributed on the surface of the microridge-coated Ti wire substrate, which increases the contact area between the substrate and the TiO2 layer in order to suppress the electron recombination and scatters the incident light to further improve the light-harvesting ability. Therefore, the charge collection and power conversion efficiencies of the novel FDSSC have been accordingly enhanced by 17.7% and 61.6%, respectively, compared with traditional FDSSC. Moreover, the structural stability of the novel FDSSC has been strengthened.",
        "keywords": [
            "Fiber-shaped dye-sensitized solar cell",
            "Titanium based photoanode",
            "Charge collection efficiency",
            "Light scattering",
            "Light harvesting"
        ],
        "authors": [
            {
                "name": "Guicheng Liu",
                "org": "Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Manxiang Wang",
                "org": "College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China;Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Hui Wang",
                "org": "MOE Laboratory of Bioinorganic and Synthetic Chemistry, The Key Lab of Low-Carbon Chemistry & Energy Conservation of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China;"
            },
            {
                "name": "Ryanda Enggar Anugrah Ardhi",
                "org": "Division of Energy and Environment Technology,KIST School, Korea, University of Science and Technology (UST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Hyunjin Yu",
                "org": "Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Dechun Zou",
                "org": "College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;"
            },
            {
                "name": "Joong Kee Lee",
                "org": "Division of Energy and Environment Technology,KIST School, Korea, University of Science and Technology (UST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            }
        ],
        "venue": "Nano Energy",
        "year": 2018
    },
    "ZyJflR2L": {
        "id": "ZyJflR2L",
        "title": "Study on a stretchable, fiber-shaped, and TiO 2 nanowire array-based dye-sensitized solar cell with electrochemical impedance spectroscopy method",
        "abstract": "Abstract   A spring-like Ti@TiO 2  nanowire array wire has been introduced into a stretchable fiber-shaped dye-sensitized solar cell (FDSSC) as a photoanode to achieve high flexibility and elasticity in this paper. Given the TiO 2  layer, which was prepared by a hydrothermal reaction in the optimized NaOH concentration of 2.5\u202fmol\u202fL \u22121 , with a 1D structure and high adhesion between the TiO 2  nanowire array and the Ti wire substrate, the novel FDSSC still possesses photoelectric conversion efficiency retention rates of approximately 97.00% and 95.95% after bending to a radius of 1.0\u202fcm and stretching to 100% strain, respectively. EIS result shows the degradation mechanism of the FDSSC photoelectric performance: the bending test leads to more terrible electron combination; the stretching operation increases the internal resistance and charge-transfer resistance at the counter electrode. Moreover, itu0027s worth noting that, this is the first time to show a 100%-stretching degree in the FDSSC research field so far.",
        "keywords": "",
        "authors": [
            {
                "name": "Guicheng Liu",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea"
            },
            {
                "name": "Hui Wang",
                "org": ""
            },
            {
                "name": "Manxiang Wang",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea"
            },
            {
                "name": "Manxiang Wang",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea"
            },
            {
                "name": "Wenbing Liu",
                "org": "Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China"
            },
            {
                "name": "Ryanda Enggar Anugrah Ardhi",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea"
            },
            {
                "name": "Dechun Zou",
                "org": "College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China"
            },
            {
                "name": "Joong Kee Lee",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea"
            },
            {
                "name": "Joong Kee Lee",
                "org": "Center for Energy Convergence Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea"
            }
        ],
        "venue": "Electrochimica Acta",
        "year": 2018
    },
    "ZG7zQ8Xw": {
        "id": "ZG7zQ8Xw",
        "title": "Hierarchically structured photoanode with enhanced charge collection and light harvesting abilities for fiber-shaped dye-sensitized solar cells",
        "abstract": "The performances of fiber dye-sensitized solar cells (FDSSCs), in terms of charge collection efficiency, light-harvesting ability, and structural stability, are improved through a novel hierarchically structured photoanode based on a Ti microridge/nanorod-modified wire substrate. The microridge made of several Ti micropits is inserted into TiO2 layer to shorten the photoelectron transport distance from the original place in the TiO2 layer to substrate and to increase the electron transport rate. The Ti micropits are used as light-gathering centers to collect the reflected light. Meanwhile, the Ti nanorods are evenly distributed on the surface of the microridge-coated Ti wire substrate, which increases the contact area between the substrate and the TiO2 layer in order to suppress the electron recombination and scatters the incident light to further improve the light-harvesting ability. Therefore, the charge collection and power conversion efficiencies of the novel FDSSC have been accordingly enhanced by 17.7% and 61.6%, respectively, compared with traditional FDSSC. Moreover, the structural stability of the novel FDSSC has been strengthened.",
        "keywords": [
            "Fiber-shaped dye-sensitized solar cell",
            "Titanium based photoanode",
            "Charge collection efficiency",
            "Light scattering",
            "Light harvesting"
        ],
        "authors": [
            {
                "name": "Guicheng Liu",
                "org": "Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Manxiang Wang",
                "org": "College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China;Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Hui Wang",
                "org": "MOE Laboratory of Bioinorganic and Synthetic Chemistry, The Key Lab of Low-Carbon Chemistry & Energy Conservation of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China;"
            },
            {
                "name": "Ryanda Enggar Anugrah Ardhi",
                "org": "Division of Energy and Environment Technology,KIST School, Korea, University of Science and Technology (UST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Hyunjin Yu",
                "org": "Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            },
            {
                "name": "Dechun Zou",
                "org": "College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;"
            },
            {
                "name": "Joong Kee Lee",
                "org": "Division of Energy and Environment Technology,KIST School, Korea, University of Science and Technology (UST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;Center for Energy Storage Research, Green City Research Institute, Korea Institute of Science and Technology (KIST), Hwarang-ro 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea;"
            }
        ],
        "venue": "Nano Energy",
        "year": 2018
    },
    "X78tPR32": {
        "id": "X78tPR32",
        "title": "Waveguide fiber dye-sensitized solar cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ming peng",
                "org": ""
            },
            {
                "name": "xiao yu",
                "org": ""
            },
            {
                "name": "xin cai",
                "org": ""
            },
            {
                "name": "qingyi yang",
                "org": ""
            },
            {
                "name": "hsienwei hu",
                "org": ""
            },
            {
                "name": "kai yan",
                "org": ""
            },
            {
                "name": "hui wang",
                "org": ""
            },
            {
                "name": "bin dong",
                "org": ""
            },
            {
                "name": "furong zhu",
                "org": ""
            },
            {
                "name": "dechun zou",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "SK66Kb8S": {
        "id": "SK66Kb8S",
        "title": "Improving the photovoltaic performance and flexibility of fiber-shaped dye-sensitized solar cells with atomic layer deposition",
        "abstract": "A conformal and thin TiO2 film fabricated with atomic layer deposition (ALD) improves the performance of fiber-shaped dye-sensitized solar cells (FDSSCs). Electrical contact at Ti/TiO2 is improved through insertion of a uniform and pinhole-free TiO2 film. The film thickness varies from 5 nm to 40 nm, and the high power conversion efficiency of 7.41% is achieved from a typical device with a 15 nm TiO2 film and a 10 \u03bcm TiO2 nanoparticles layer. The compact and high-quality TiO2 film improves Ti/TiO2 interfacial property. Surface modification hastens electron transport, which thus improves the charge collection efficiency. Both photocurrent density and bending performance are significantly enhanced compared with those of the corresponding FDSSCs without ALD treatment.",
        "keywords": [
            "Fiber-shaped dye-sensitized solar cells",
            "Atomic layer deposition",
            "Flexible",
            "Charge collection efficiency"
        ],
        "authors": [
            {
                "name": "weixing song",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, China;"
            },
            {
                "name": "hui wang",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, China;"
            },
            {
                "name": "guicheng liu",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, China;"
            },
            {
                "name": "ming peng",
                "org": "Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;"
            },
            {
                "name": "dechun zou",
                "org": "Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, China;"
            },
            {
                "name": "",
                "org": ""
            }
        ],
        "venue": "Nano Energy",
        "year": 2016
    },
    "HSppZaHc": {
        "id": "HSppZaHc",
        "title": "Low-Temperature Synthesis of Near-Monodisperse Globular MoS2 Nanoparticles with Sulphur Powders",
        "abstract": "Nanoparticles (NPs) with high uniformity have been extensively investigated for their excellent chemical stability. Near-monodisperse globular MoS2 NPs were prepared with sulphur powders (SPs) as a sulphur source by a one-pot polyol-mediated process without surfactants, transfer agents and toxic agents at 170\u2013190\u2218C. The as-processed SPs greatly affected the formation of the MoS2 NPs after low-activity sulphur (S8)n was reassembled from common SPs (S8). The average size of MoS2 NPs can be reduced remarkably from 100\u2013200nm to 50nm by introducing low amounts of MnCl2. A preliminary four-step growth mechanism based on the aggregation-coalescence model was also proposed. This green and simple method may be an alternative to the common hot-injection and heating-up methods for the preparation of monodisperse NPs, particularly transition metal dichalogenides.",
        "keywords": "",
        "authors": [
            {
                "name": "Hui Wang",
                "org": ""
            },
            {
                "name": "Xuequan Li",
                "org": ""
            },
            {
                "name": "Kai Yan",
                "org": ""
            },
            {
                "name": "Guicheng Liu",
                "org": ""
            },
            {
                "name": "Weixing Song",
                "org": ""
            },
            {
                "name": "Ting Shen",
                "org": ""
            },
            {
                "name": "Dechun Zou",
                "org": ""
            }
        ],
        "venue": "NANO",
        "year": 2017
    },
    "VO7xLOnk": {
        "id": "VO7xLOnk",
        "title": "An 8.07% efficient fiber dye-sensitized solar cell based on a TiO2 micron-core array and multilayer structure photoanode",
        "abstract": "Ti/TiO2 micron-cone array (TMCA) prepared through a synergy of chemical and electrochemical reactions was used as the frame and electron transfer channel for the photoanode of a fiber dye-sensitized solar cell (FDSSC). A TiO2 multilayer structure composed of compact, light scattering, and porous layers was introduced into the fiber photoanode for the first time based on the TMCA. The novel fiber photoelectric device attained a photoelectric conversion efficiency of 8.07%, the highest value for FDSSCs with a Pt wire counter electrode to date, and a good flexibility.",
        "keywords": [
            "Fiber dye-sensitized solar cell",
            "Photoanode",
            "Ti/TiO2 micron-core array",
            "Light scattering layer",
            "Multilayer structure"
        ],
        "authors": [
            {
                "name": "Guicheng Liu",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, P. R. China;"
            },
            {
                "name": "Ming Peng",
                "org": "Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China;"
            },
            {
                "name": "Weixing Song",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, P. R. China;"
            },
            {
                "name": "Hui Wang",
                "org": "Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, P. R. China;"
            },
            {
                "name": "Dechun Zou",
                "org": "Beijing National Laboratory for Molecular Sciences, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China;Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, 30 Xueyuan Road, Haidian District, Beijing 100083, P. R. China;"
            }
        ],
        "venue": "Nano Energy",
        "year": 2015
    },
    "c9qE3xkt": {
        "id": "c9qE3xkt",
        "title": "Network Modeling of Olfactory Bulb Neurons and Study of Information Coding",
        "abstract": "On the basis of the bulb physiological anatomic structure,a comparatively integrated bulb neural electrophysiological model incorporating periglomerular cells(PG),mitral cells(MC) and granule cells(GC) is constructed here originally by means of their ion channels and neurotransmitters among the dendrodendritic synapses in the neural cell network.This model preliminarily reveals the mechanisms of spatiotemporal coding of the odor information from olfactory sensory neurons and odor recognization of the bulb.It lays a good foundation for the further studies of the different mechanisms of PG,MC and GC cells in olfactory bulb coding as well as the odor pattern recognization based on the bulb physiological structure.",
        "keywords": [
            "olfactory bulb",
            "neural network modeling",
            "olfactory coding",
            "olfactory system"
        ],
        "authors": [
            {
                "name": "LIU Feng",
                "org": "Department of Biomedical Engineering,Zhejiang University,Hangzhou,Zhejiang ,China;Key Laboratory of BME of the Ministry of Education,Zhejiang University,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "YE Xue-song",
                "org": "Department of Biomedical Engineering,Zhejiang University,Hangzhou,Zhejiang ,China;Key Laboratory of BME of the Ministry of Education,Zhejiang University,Hangzhou,Zhejiang ,China;Qiushi Academy for Advanced Studies,Zhejiang University,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "SHEN Xiao-mei",
                "org": "Department of Biomedical Engineering,Zhejiang University,Hangzhou,Zhejiang ,China;Key Laboratory of BME of the Ministry of Education,Zhejiang University,Hangzhou,Zhejiang ,China;Qiushi Academy for Advanced Studies,Zhejiang University,Hangzhou,Zhejiang ,China"
            },
            {
                "name": "XIA Ling",
                "org": "Department of Biomedical Engineering,Zhejiang University,Hangzhou,Zhejiang ,China;Key Laboratory of BME of the Ministry of Education,Zhejiang University,Hangzhou,Zhejiang ,China"
            }
        ],
        "venue": "Acta Electronica Sinica",
        "year": 2009
    },
    "YbIz2PeD": {
        "id": "YbIz2PeD",
        "title": "Development of MEA-based Olfactory Neural Chip and Its Testing System",
        "abstract": "Objective To find an efficient way for developing olfactory neural chip and its measurement system of electro-physiological signals with Multi-electrode Array(MEA),furthermore,to verify the efficiency of this detection system for electro-physiological signals of neural system and others.Methods The acquisitions from electro-cardio signals of rat hearts in vitro and from self-issuing signals of hippocampus neural networks on MEA chip,as well the electro-physiological signals of olfactory bulb neural network neuron chips made of cultured neonatal rat olfactory bulb neuron according to different shapes at different culturing periods,were performed with 72-channel signal condition circuits and an acquisition system developed in our lab.Those shapes of olfactory bulb networks at different culturing periods were observed and compared by optical microscopy.Results It was apparent that the detection platform integrated with MEA sensors could be used to capture electro-physiological signals of olfactory bulb neural networks at different cultured periods,and those data acquired could be used to analyze complexity and temporal coding of electrophysiological signals of neural networks.Conclusion The neural signal detection platform developed here is capable of being broadly used on the studies of neural electrophysiology and neural biology.",
        "keywords": [
            "neuron network",
            "planary micro-electrode array",
            "neuron signal acquisition",
            "olfactory neural chip"
        ],
        "authors": [
            {
                "name": "LIU Feng",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            },
            {
                "name": "ZHENG Qian-qian",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            },
            {
                "name": "SHEN Xiao-mei",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            },
            {
                "name": "LI Yi-qiao",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            },
            {
                "name": "LING Shu-cai",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            },
            {
                "name": "ZHENG Xiao-xiang",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            },
            {
                "name": "YE Xue-song",
                "org": " College of Biomedical Engineering & Instrument Science,Zhejiang University,Hangzhou Zhejiang ,China"
            }
        ],
        "venue": "Space Medicine & Medical Engineering",
        "year": 2009
    },
    "3rB09qar": {
        "authors": [
            {
                "name": "X. Wang",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "G. Wang",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "R. You",
                "org": "Dept. of Prec. Instrum./Mechanology"
            }
        ],
        "title": "A novel micro air speedometer",
        "abstract": "Micro Air Vehicle is an intelligent microsystem applying MEMS technologies. According to the requirements of MAV, a novel micro air speedometer is presented in this paper. The detector of the device is an encoder driven by a micro propeller, and the signal processor is a SCM. A speedometer demonstration system is also presented in this paper.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "3rB09qar"
    },
    "c3DqlzgH": {
        "authors": [
            {
                "name": "G. Wang",
                "org": "Dept. Precision Inst. Tsinghua Univ."
            },
            {
                "name": "X. Wang",
                "org": "Dept. Precision Inst. Tsinghua Univ."
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. Precision Inst. Tsinghua Univ."
            },
            {
                "name": "Z. Shi",
                "org": "Dept. Precision Inst. Tsinghua Univ."
            }
        ],
        "title": "Research and design on micro altimeter",
        "abstract": "A new kind of micro altimeter is introduced. The basic principle, design, fabrication, connection with control system and performance of sensor is analyzed. The altimeter, which is 30 mm \u00d7 20 mm \u00d7 20mm in size, less than five gram, has the precision better than positive and negative three meter, and the sensitivity high than 1 meter, reach and exceed the requirement of design, is with great practicability. It has been used in some of vehicles, robots, MAVs(Micro Aerial Vehicles,) and MMCU(Micro Measurement Control Unit).",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "c3DqlzgH"
    },
    "R7GXjrMe": {
        "authors": [
            {
                "name": "H. Wu",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "Z. Zhou",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "S. Xiong",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "D. Yan",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "G. Zhang",
                "org": "Department of Precision Instruments"
            }
        ],
        "title": "Experimental studies on muscle fatigue of human limb motion with FNS",
        "abstract": "The basic characteristic of the functional neuromuscular stimulation signals suitable to body is preliminarily determined after the fatigue performance of the biceps, and the physiological reaction to stimulation is investigated using many continuous stimulation signal patterns. The flexion motion of the elbow joint (right hand) of a healthy man was taken as out research objective. The surface electrodes were connected to the biceps and a micro angle sensor was mounted on the elbow joint (right hand). The curves of angular displacement for the elbow joint motion were obtained by using functional neuromuscular stimulation (FNS) limbs motion measurement instruments. The results demonstrate that the biceps are characterized by the non-linear and time-variant no matter what the stimulation patterns are, that continuous slow stimulation signals can reduce the muscle fatigue of the biceps, and that the stimulation frequencies ranging from 30 Hz to 50 Hz are applicable to the neuromuscular system.",
        "keywords": [
            "Fatigue characteristics",
            "Flexion motion",
            "Functional neuromuscular stimulation",
            "Stimulation pattern"
        ],
        "venue": "Shengwu Yixue Gongchengxue Zazhi/Journal of Biomedical Engineering",
        "year": 2001,
        "id": "R7GXjrMe"
    },
    "oNM5gZXN": {
        "authors": [
            {
                "name": "C. Liu",
                "org": "Institute For Micromanufacturing"
            },
            {
                "name": "T. Cui",
                "org": "Institute For Micromanufacturing"
            },
            {
                "name": "Z. Zhou",
                "org": "Department of Precision Instruments"
            }
        ],
        "title": "Modal analysis of a unimorph piezoelectrical transducer",
        "abstract": "Piezoelectric transducers are widely applied to MEMS devices as actuators or sensors due to their simple structure and easy control. A micromachined piezoelectric microjet is introduced and modal analysis of its piezoelectric actuator has been thoroughly presented. Both numerical analysis and experimental measurement are implemented in this study. In numerical analysis, an approximate method is established to evaluate the first vibration mode and finite-element methods are used to simulate higher order vibration modes of the transducer. An experimental system was also set up to measure the axisymmetric vibration modes of the transducer. Compared with experimental results, good correlation was found between the numerical and experimental results, which proved the validation and reliability of the models. Through these models, further optimal design of the transducer can be carried out.",
        "keywords": [
            ""
        ],
        "venue": "Microsystem Technologies",
        "year": 2003,
        "id": "oNM5gZXN"
    },
    "Q2vkK2ec": {
        "authors": [
            {
                "name": "D. Yan",
                "org": "Dept. of Prec. Instruments and Mech."
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. of Prec. Instruments and Mech."
            },
            {
                "name": "S. Xiong",
                "org": "Dept. of Prec. Instruments and Mech."
            }
        ],
        "title": "Effects of feature optimization in pattern recognition of surface electromyography",
        "abstract": "Electromyography (EMG) is a bio-electrical manifestation related to neuromuscular activities. It has been used widely in various field of biomedicine, where pattern recognition plays an important role. Feature optimization was introduced in the pattern recognition of surface electromyography and is presented in this paper, and its effects are discussed in detail. With experiments from seven volunteers, it showed that the average recognition rate of the motions can improve by 12%. It also shows that, without new original information, the separability of features could be improved with appropriate optimization method, so that the probablity to recognize patterns of motions can be improved. The feature optimization does play important role in the process of pattern recognition, which would promote practical applications, such as the fielde of rehabilitation etc.",
        "keywords": [
            "Electromyography",
            "Feature optimization",
            "Orthogonal projection",
            "Pattern recognition"
        ],
        "venue": "Beijing Shengwu Yixue Gongcheng/Beijing Biomedical Engineering",
        "year": 2001,
        "id": "Q2vkK2ec"
    },
    "EykacffV": {
        "authors": [
            {
                "name": "J. Zhu",
                "org": ""
            },
            {
                "name": "Z. Zhou",
                "org": ""
            },
            {
                "name": "H. Ding",
                "org": ""
            },
            {
                "name": "X. Ye",
                "org": ""
            }
        ],
        "title": "Fabrication of micro tunneling magnetometer and on-wafer test",
        "abstract": "A novel micro magnetometer based on electron tunneling is presented. It utilizes the high sensitivity nature of electron tunneling effect, so it's expected to have very high resolution. The sensor is fabricated using silicon-glass bonding process. In order to determine the characteristics of the sensor, plates similar to the functional structure of the magnetometer are fabricated on the same wafer to determine the mechanical properties of the thin film (on-wafer test). A new resonance method to measure the residual stress is also presented.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "EykacffV"
    },
    "2eJ2ZcA3": {
        "authors": [
            {
                "name": "H. Wu",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "S. Xiong",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "X. Wang",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "X. Ye",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "Y. Li",
                "org": "Dept. of Prec. Instrum./Mechanology"
            }
        ],
        "title": "Simulation of aerodynamics of Micro Air Vehicles at Low Reynolds numbers",
        "abstract": "Micro Air Vehicles (MAV) are of great interest of military and civilian applications. In this paper, one newly-designed prototype Micro Air Vehicle TF380 with the span of 380 millimeters, the speed of 20-30 mph, and the weight of 5 ounces and radio remote control at Tsinghua University is introduced. Comparisons and analyses of the aerodynamics for MAV TF380 associated with several airfoils at Low Reynolds number (<1/2 millions) are investigated in details. Based on the computational performances, an airfoil-optimized MAV TF380 is obtained. The maiden flight-testing of MAV TF380 is successful.",
        "keywords": [
            "Aerodynamics",
            "Flight-testing",
            "Low Reynolds number",
            "MAV",
            "Simulation"
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "2eJ2ZcA3"
    },
    "hGkHBsBK": {
        "authors": [
            {
                "name": "H. Wu",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "S. Xiong",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "X. Wang",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "R. Zhu",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "S. Li",
                "org": "Dept. of Prec. Instrum./Mechanology"
            },
            {
                "name": "G. Bao",
                "org": "Dept. of Prec. Instrum./Mechanology"
            }
        ],
        "title": "Multisensor data fusion (MSDF) applied to micro measurement and control unit (MMCU)",
        "abstract": "Multisensor data fusion (MSDF) has already been widely used in various applications in which multiple sources of information are presented. In this paper, the basic concept of multisensor data fusion technique is summarized. A new notion of micro measurement and control unit (MMCU) is proposed, which is applicable to many fields including aerial vehicles, aerial robot, etc. The general functions and features of MMCU are detailed. A significant MMCU intelligent test system architecture based on MSDF is developed. Some algorithms used in MMCU data fusion method are briefly described.",
        "keywords": [
            "MAV",
            "MEMS",
            "MMCU",
            "MSDF"
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "hGkHBsBK"
    },
    "e594D2ap": {
        "authors": [
            {
                "name": "X. Han",
                "org": ""
            },
            {
                "name": "J. Yang",
                "org": ""
            },
            {
                "name": "Y. Guan",
                "org": ""
            },
            {
                "name": "Z. Zhou",
                "org": ""
            },
            {
                "name": "W. Zhao",
                "org": ""
            },
            {
                "name": "A.R. Allouche",
                "org": ""
            },
            {
                "name": "S. Magnier",
                "org": ""
            },
            {
                "name": "E.H. Ahmed",
                "org": ""
            },
            {
                "name": "A.M. Lyyra",
                "org": ""
            },
            {
                "name": "X. Dai",
                "org": ""
            }
        ],
        "title": "Observation of the 4",
        "abstract": "Using Infrared-Infrared Double Resonance (IIDR) high resolution spectroscopy, we have observed the 20 200-21 600 cm",
        "keywords": [
            ""
        ],
        "venue": "Chemical Physics Letters",
        "year": 2014,
        "id": "e594D2ap"
    },
    "lXpEjm2a": {
        "authors": [
            {
                "name": "G. Wang",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "Z. Shi",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "Z. Zhou",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "X. Ye",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "Y. Feng",
                "org": "Department of Precision Instruments"
            },
            {
                "name": "Y. Tang",
                "org": "Department of Precision Instruments"
            }
        ],
        "title": "Microfluidic analysis system based on capillary electrophoresis chip",
        "abstract": "In biologic and chemical analysis system, both of high-speed analysis and real time data processing is important. A kind of microfludic sample, separation and dynamic process instrument has been built and tested. A typical sample stacking and separation image obtained with this instrument Preliminary on-chip reaction experiments are imaged using this detection system. The system based on focusing an expanded laser beam onto chip using a cylindrical lens then detecting the separated signal with a photomultiplier tube (PMT) is illustrated Excellent signal/noise ratio was obtained while compared with traditional electrophoresis methods.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "lXpEjm2a"
    },
    "UzUGdc4s": {
        "authors": [
            {
                "name": "J. Lan",
                "org": ""
            },
            {
                "name": "H. Li",
                "org": ""
            },
            {
                "name": "Z. Zhou",
                "org": ""
            }
        ],
        "title": "Research on feature extraction of seismic signal for vehicle targets and neural networks recognition",
        "abstract": "The seismic properties of typical vehicle targets are studied and artificial neural network (ANN) technology is applied to recognition of seismic signal for target. An improved BP algorithm is presented which is used for classification and recognition of seismic signal for vehicle target under special outdoor environment. It can be confirmed that ANN is effective to solve the problem of classification and recognition of seismic signal for vehicle target.",
        "keywords": [
            "Neural networks",
            "Seismic detection",
            "Target recognition"
        ],
        "venue": "Journal of Vibration and Shock",
        "year": 2001,
        "id": "UzUGdc4s"
    },
    "Z4Bcv75t": {
        "authors": [
            {
                "name": "J. Xiong",
                "org": ""
            },
            {
                "name": "Z. Zhou",
                "org": ""
            },
            {
                "name": "X. Ye",
                "org": ""
            },
            {
                "name": "X. Wang",
                "org": ""
            },
            {
                "name": "Y. Feng",
                "org": ""
            }
        ],
        "title": "Research on colloid thruster and thrust measurement system",
        "abstract": "With the advent of nanosatellite designs, colloid micro-thruster technology has been triggered the rebirth. The basic principle of a colloid thruster is firstly described in this paper. After that a model colloid thruster system consisting of propellant supplying unit and thrust unit is also introduced. In the third part of this paper, two micro thrust measurement methods are discussed. At last, some conclusions are presented.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "Z4Bcv75t"
    },
    "AuWVFry2": {
        "authors": [
            {
                "name": "R. Zhu",
                "org": "MEMS Lab."
            },
            {
                "name": "Z. Zhou",
                "org": "MEMS Lab."
            }
        ],
        "title": "Hybrid simulations for azimuth-gradienter",
        "abstract": "Exact knowledge of the attitude of a vehicle is a fundamental problem in vehicle applications. In search for a solution, researchers and engineers have developed a variety of systems, sensors, and techniques. This paper provides an azimuth-gradienter, which is a mini attitude sensor based on micro electromechanical system (MEMS). The composing of the azimuth-gradienter and the characteristics of its parts, such as magnetometer and accelerometer are also discussed. For testing the static and dynamic performances of the azimuth-gradienter in real measure, the hybrid simulations with an analog simulation and a semi-physical simulation by using a three-axis simulator are performed. The results show that the azimuth-gradienter can measure pitch, roll and heading for a vehicle that is moving in three-dimension with wide range of attitude. The range of measure is -90\u00b0 \u223c+90\u00b0 for pitch, -180\u00b0 \u223c+180\u00b0 for roll, and 0 \u00b0 \u223c360\u00b0 for heading, which do adapt to measure the attitude for various vehicles, especially for aircraft. The attitude can be measured to 0.5 \u00b0 precision, and the sensitivity approaches 0.1 \u00b0 Furthermore, the testing indicates that the sensor gains high speed of response with quite short time lag, so as to make the attitude control Real-time.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "AuWVFry2"
    },
    "ct1BU2P0": {
        "authors": [
            {
                "name": "H. Wu",
                "org": "Dept. Precision Instr. Mechanology"
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. Precision Instr. Mechanology"
            },
            {
                "name": "S. Xiong",
                "org": "Dept. Precision Instr. Mechanology"
            },
            {
                "name": "X. Wang",
                "org": "Dept. Precision Instr. Mechanology"
            },
            {
                "name": "S. Li",
                "org": "Dept. Precision Instr. Mechanology"
            },
            {
                "name": "J. Xiong",
                "org": "Dept. Precision Instr. Mechanology"
            },
            {
                "name": "Z. Li",
                "org": "Dept. Precision Instr. Mechanology"
            }
        ],
        "title": "Study on multi-variable control strategies for micro air vehicles hovering flight",
        "abstract": "The paper considers the multi-channel remote control signals processing required for hovering flight required for the Micro Air Vehicles (MAVs). The multi-variable time Series analysis approach is applied to modeling and simulation of the four-channel man-manipulated signals to control the MAV hovering flight. Different multi-variable autoregressive (MVAR) models are identified using the multi-channel remote control signals sampled from the MAV remote controller. The final prediction error (FPE) related to each MVAR model is detailed. The results demonstrate that two variables with the flap and the elevator play a critical role in controlling MAV hovering flight and the other two variables with the thruster and the rudder may be kept the line.",
        "keywords": [
            "AR",
            "Flight control",
            "MAV",
            "Modeling",
            "Simulation"
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "ct1BU2P0"
    },
    "jdddZ3Pv": {
        "authors": [
            {
                "name": "R. Zhu",
                "org": "MEMS Lab."
            },
            {
                "name": "Z. Zhou",
                "org": "MEMS Lab."
            }
        ],
        "title": "A novel signal processing method for azimuth-gradienter based on MEMS",
        "abstract": "This paper discusses a new signal processing method for reducing the existing errors and getting stable output for the azimuth-gradienter based on micro electromechanical system (MEMS). The azimuth-gradienter is composed of magnetometers and accelerometers. The stochastic noises, drifts and instability come from a variety of reasons, such as magnetic field fluctuations, electrical fluctuations, and external disturbance, which are inevitable in magnetometers and accelerometers. Considering about these influences, an applied and effective signal processing method has been developed. Firstly, we design a self-adaptive non-linear filter aiming at the characteristics of the measured signals. The original measured angle and its forward shifts are as the inputs of the filter, and the output is as the estimation of the real heading angle. By properly evaluating and updating the parameters for the filter, its output will surely approach to the real value with less error compared with the original measure. Secondl y, integrating the errors and the increments of errors in criterion function and minimizing it propose an advanced algorithm. The algorithm is used to perform the parameter learning of the filter. The application results show that the above design provides a fast and effective way for eliminating noises and stabilizing the angle output.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "jdddZ3Pv"
    },
    "ZuvNstyS": {
        "authors": [
            {
                "name": "S. Xiong",
                "org": "Dept. Prec. Instrum. Mechanology"
            },
            {
                "name": "Z. Zhou",
                "org": "Dept. Prec. Instrum. Mechanology"
            }
        ],
        "title": "Dynamic parameter estimation of velocity sensors using an indirect measurement approach",
        "abstract": "An indirect measurement method is proposed for the dynamic parameter estimation of velocity sensors. This approach makes use of data processing abilities of computers and does not require high precision devices. Under the indirect measurement mode, the relationship between the input voltage and the output current of the testing system can be described by a third-order transfer function including physical parameters of the sensor. An identification method for transfer functions with a two step algorithm is presented based on the spectral analysis. The spectral density functions are first obtained from input-output signals of a system, then the dynamic parameters can be estimated from frequency response data. Some parameter estimation algorithms are derived by minimizing a unified loss function with different weight selections and the estimation errors are analyzed. By use of the indirect measurement approach and the modeling algorithms, we can get enough precision results. When the transfer function under the indirect measurement mode is determined, the transfer function in the working state can be obtained through the relationship between the models in the measuring state and in the working state. The methods suggested in the paper can be widely used in the modeling of mechanic-electric systems.",
        "keywords": [
            "Dynamic parameter estimation",
            "Frequency domain",
            "Measurement",
            "Transfer function",
            "Velocity sensor"
        ],
        "venue": "Conference Record - IEEE Instrumentation and Measurement Technology Conference",
        "year": 2001,
        "id": "ZuvNstyS"
    },
    "OzjsQfDQ": {
        "authors": [
            {
                "name": "S. Li",
                "org": "Department of PIM"
            },
            {
                "name": "Z. Zhou",
                "org": "Department of PIM"
            },
            {
                "name": "G. Wang",
                "org": "Department of PIM"
            },
            {
                "name": "H. Wu",
                "org": "Department of PIM"
            },
            {
                "name": "S. Xiong",
                "org": "Department of PIM"
            },
            {
                "name": "X. Wang",
                "org": "Department of PIM"
            },
            {
                "name": "J. Xiong",
                "org": "Department of PIM"
            }
        ],
        "title": "Research on computer control system of MAV",
        "abstract": "As the research of MAV has developed quickly, control system has been more and more important. The author discussed the key points in study of automatic control of Micro Air Vehicle and summarized the 3 main steps in process. Along with analysis of data of experiment, one of the projects was described particularly.",
        "keywords": [
            "Control",
            "MAV",
            "On-flight"
        ],
        "venue": "Proceedings of the International Symposium on Test and Measurement",
        "year": 2001,
        "id": "OzjsQfDQ"
    },
    "8MjVMtUh": {
        "authors": [
            {
                "name": "Z. Xiaobo",
                "org": ""
            },
            {
                "name": "Z. Zhou",
                "org": ""
            }
        ],
        "title": "Algorithms for Toyota's goal of sequencing mixed models on an assembly line with multiple workstations",
        "abstract": "Toyota's goal of sequencing mixed models on an assembly line is to keep the constant usage rate of every part used in the assembly line. This paper deals with Toyota's goal of sequencing mixed models on an assembly line with multiple workstations. A sequencing problem with Toyota's goal is formulated. Two algorithms based on different mechanisms, respectively modified goal chasing and simulated annealing, are developed for solving the sequencing problem. A number of numerical experiments are carried out for evaluating the efficiency of the algorithms. Computational results show that one of the algorithms generates good sub-optimal solutions with very short CPU times, while the other can reach optimal solutions with longer, but acceptable, CPU times.",
        "keywords": [
            ""
        ],
        "venue": "Journal of the Operational Research Society",
        "year": 1999,
        "id": "8MjVMtUh"
    },
    "zjYKynk2": {
        "id": "zjYKynk2",
        "title": "Alloyed multi-shell quantum dots with tunable dual emission",
        "abstract": "In this work, we synthesized ZnxCd1\u2212xSe/ZnS/ZnyCd1\u2212ySe/ZnS dual emission-alloyed QDs for the first time. Through introducing a ZnS barrier layer, we avoid exciton diffusion to realize dual emission. By adjusting the composition of the core and the quantum well (QW) layer, the emission wavelength can be effectively tuned from 550 to 710 nm and 500 to 550 nm, respectively. The photoluminescence (PL) intensity of the QW layer can also be adjusted by changing the annealing time and the thickness of the outmost ZnS layer, which was the result of reduction of the defects of the QW layer. The highest quantum yield (QY) was over 50% for the dual emission-alloyed QDs. Moreover, this material also exhibited high photostability, and even being exposed to 365 nm Hg lamp irradiation for 12 h, the QY was still maintained at about 85% of the unirradiated level. The energy transfer efficiency between the core and the QW is calculated to be 48% using time-resolved PL spectra.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenda Zhang",
                "org": "National Engineering Research Center for Rare Earth Materials, General Research Institute for Nonferrous Metals, and Grirem Advanced Materials Co., Ltd.,Beijing 100088,People's Republic of China"
            },
            {
                "name": "Weidong Zhuang",
                "org": ""
            },
            {
                "name": "Xianran Xing",
                "org": "Department of Physical Chemistry, University of Science & Technology Beijing,Beijing 100083,People's Republic of China"
            },
            {
                "name": "Bing Xu",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Dan Wu",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Haochen Liu",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Kai Wang",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Ronghui Liu",
                "org": ""
            },
            {
                "name": "Xiao Wei Sun",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2018
    },
    "sz6gi2pz": {
        "id": "sz6gi2pz",
        "title": "Correction: Bright and efficient light-emitting diodes based on MA/Cs double cation perovskite nanocrystals",
        "abstract": "Correction for \u2018Bright and efficient light-emitting diodes based on MA/Cs double cation perovskite nanocrystals\u2019 by Bing Xu et al., J. Mater. Chem. C, 2017, 5, 6123\u20136128.",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Xu",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Bing Xu",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Weigao Wang",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Xiaoli Zhang",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Xiaoli Zhang",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Wanyu Cao",
                "org": "Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University,Tianjin 300072,China"
            },
            {
                "name": "Dan Wu",
                "org": "School of Electrical & Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue,,Singapore"
            },
            {
                "name": "Sheng Liu",
                "org": ""
            },
            {
                "name": "Haitao Dai",
                "org": "Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University,Tianjin 300072,China"
            },
            {
                "name": "Shuming Chen",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Kai Wang",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Xiao Wei Sun",
                "org": "Department of Electrical & Electronic Engineering, Southern University of Science and Technology,Shenzhen,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2018
    },
    "hdtfiNBm": {
        "id": "hdtfiNBm",
        "title": "Bright and efficient light-emitting diodes based on MA/Cs double cation perovskite nanocrystals",
        "abstract": "A high quantum yield, tunable band gap, and high color purity of perovskite nanocrystals make this class of materials attractive for electronic and optoelectronic applications in devices including solar cells, photodetectors, and light emitting diodes. Herein, we report for the first time the facile synthesis of perovskite nanocrystals based on (CH3NH3)1\u2212xCsxPbBr3. The emission properties, photoluminescence and stability of the mixed-cation perovskite nanocrystals have been intensively studied, which are significantly related to the content of cesium in the composition. The as-obtained (CH3NH3)1\u2212xCsxPbBr3 nanocrystals were employed as the emission layer in perovskite light emitting diodes, and the device fabricated with the optimized perovskite nanocrystals (Cs doping x = 0.3) showed a maximum luminescence of 24\u2006500 cd m\u22122, nearly ten-fold higher than those for the previous reported perovskite devices based on MAPbBr3 nanocrystals. This study opens a new avenue for the fabrication of efficient perovskite nanocrystals and provides great potential of developing perovskite LEDs based on mixed-cation perovskite nanocrystals.",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Xu",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Bing Xu",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Weigao Wang",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Xiaoli Zhang",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Xiaoli Zhang",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Wanyu Cao",
                "org": "Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University,Tianjin 300072,China"
            },
            {
                "name": "Dan Wu",
                "org": "School of Electrical & Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue,,Singapore"
            },
            {
                "name": "Sheng Liu",
                "org": ""
            },
            {
                "name": "Haitao Dai",
                "org": "Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing Technology, School of Science, Tianjin University,Tianjin 300072,China"
            },
            {
                "name": "Shuming Chen",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Kai Wang",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            },
            {
                "name": "Xiao Wei Sun",
                "org": "Department of Electrical & Electronic Engineering, Sourthern University of Science and Technology,Shenzhen,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2017
    },
    "IcfwKqLf": {
        "id": "IcfwKqLf",
        "title": "Light\u2010Emitting Diodes: Highly Efficient and Stable Luminescence from Microbeans Integrated with Cd\u2010Free Quantum Dots for White\u2010Light\u2010Emitting Diodes (Part. Part. Syst. Charact. 10/2015)",
        "abstract": "",
        "keywords": [
            "quantum dots",
            "luminescence",
            "light emitting diodes"
        ],
        "authors": [
            {
                "name": "wei chen",
                "org": "south university of science and technology of china"
            },
            {
                "name": "kai wang",
                "org": "south university of science and technology of china"
            },
            {
                "name": "junjie hao",
                "org": "south university of science and technology of china"
            },
            {
                "name": "dan wu",
                "org": "nanyang technological university"
            },
            {
                "name": "shang wang",
                "org": "bangalore development authority"
            },
            {
                "name": "jing qin",
                "org": "south university of science and technology of china"
            },
            {
                "name": "chen li",
                "org": "south university of science and technology of china"
            },
            {
                "name": "wanqiang cao",
                "org": "hubei university"
            }
        ],
        "venue": "Particle & Particle Systems Characterization",
        "year": 2015
    },
    "1CphMzwN": {
        "id": "1CphMzwN",
        "title": "Scattering enhanced quantum dots based luminescent solar concentrators by silica microparticles",
        "abstract": "Abstract   Luminescent solar concentrator (LSC) integrated with c-Si photovoltaic cells (PV cells) in building integrated photovoltaics (BIPV) could grow up to be an important element of our life for energy harvest in the future. Heavy metal free quantum dots (QDs) are promising for LSC applications, which can be controlled to possess effective large Stokes Shift and low reabsorption of emission that benefit their applications in BIPV. In our work, different amount and size of SiO 2  particles were added to CuInS 2 /ZnS QDs based LSCs to realize highly efficient scattering enhanced LSC (S-LSC) devices. Since SiO 2  particles induced scattering effect, we achieved a power conversion efficiencies (PCE) of 4.20%, which showed an improvement of 60.3% compared with the pure QDs based LSC without SiO 2  particles. This study suggests a new method of scattering enhancement to realize better performance for LSC.",
        "keywords": "",
        "authors": [
            {
                "name": "Haochen Liu",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Shang Li",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Wei Chen",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Dan Wang",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Chen Li",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Dan Wu",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Junjie Hao",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Ziming Zhou",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            },
            {
                "name": "Xinzhong Wang",
                "org": "Department of Electronic Communication and Technology, Shenzhen Institute of Information Technology, Shenzhen 518172, China"
            },
            {
                "name": "Kai Wang",
                "org": "Department of Electrical and Electronic Engineering, College of Engineering, Southern University of Science and Technology, 1088 Xueyuan Road, Shenzhen, Guangdong 518055, China"
            }
        ],
        "venue": "Solar Energy Materials and Solar Cells",
        "year": 2018
    },
    "nIljUOd9": {
        "id": "nIljUOd9",
        "title": "Highly Efficient Chip-Scale Package LED Based on Surface Patterning",
        "abstract": "Chip-scale package (CSP) light-emitting diodes (LEDs) are considered as the next generation of highly efficient package LED. However, they suffer from total internal reflection that limits their light extraction efficiency (LEE). In this letter, surface patterning, in terms of microstructures, as a well-controlled surface roughness method is designed and applied on CSP-LED to improve the LEE. Based on simulation results, pyramid and flat top pyramid structures have been designed and optimized. Four types of layouts, including tightly, interlaced, distant and chessboard layout, are also compared. A LEE enhancement of more than 20% is achieved. Furthermore, the four layouts with pyramid structures are fabricated using nano-imprint technology. The experimental results match the simulated results well with only a mismatch of 2.9%. The fabricated layout shows an enhancement of 20.31% when pyramid structures are fully filling the surface. Surface patterned CSP-LED, therefore, exhibits a great potential for high efficient LED.",
        "keywords": "",
        "authors": [
            {
                "name": "Tianqi Zhang",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Haodong Tang",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Shang Li",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Zuoliang Wen",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Xiangtian Xiao",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Yulong Zhang",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Fei Wang",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Kai Wang",
                "org": "Southern University of Science and Technology, Shenzhen, China"
            },
            {
                "name": "Dan Wu",
                "org": "Nanyang Technological University, Singapore"
            }
        ],
        "venue": "IEEE Photonics Technology Letters",
        "year": 2017
    },
    "zx4SGSzt": {
        "id": "zx4SGSzt",
        "title": "Synthesis of highly efficient and stable CH 3 NH 3 PbBr 3 perovskite nanocrystals within mesoporous silica through excess CH 3 NH 3 Br method",
        "abstract": "Abstract   Templated synthesis of CH 3 NH 3 PbBr 3  perovskite nanocrystals is facile, high-yield, ligand-free, and is another effective method aside from the colloidal method. However, the quantum yield (QY) is still inferior to that of the colloidal synthesized ones. In this report, we show that CH 3 NH 3 PbBr 3  nanocrystal within mesoporous silica with QY of 75% and full width at half-maximum (FWHM) of 22\u202fnm are obtained through manipulating the molar ratio of CH 3 NH 3 Br versus PbBr 2  in precursor solution. It is found that excess CH 3 NH 3 Br can passivate the surface trap states, reduce nanocrystal size and narrow down the size distribution effectively. These features contribute to the rising of QY, blue-shifting of emission maximum and narrowing down of FWHM. The influence of excess CH 3 NH 3 Br can be interpreted in terms of enrichment on the interface of solvent/air because of amphipathy. Moreover, these CH 3 NH 3 PbBr 3  - mesoporous silica composites present good stability. They preserve 90% of its initial QY after a storage in wet weather with relative humidity of 70\u202f\u00b1\u202f5% for 3 months. The synthesis method proposed in this research provides an effective way to achieve perovskite nanocrystals within mesoporous silica with high efficiency and stability.",
        "keywords": "",
        "authors": [
            {
                "name": "Mei Su",
                "org": "College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518000, PR China"
            },
            {
                "name": "Mei Su",
                "org": "College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518000, PR China"
            },
            {
                "name": "Dan Wu",
                "org": "Southern University of Science and Technology, Shenzhen, 518000, PR China"
            },
            {
                "name": "Bo Fan",
                "org": "College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518000, PR China"
            },
            {
                "name": "Fang Wang",
                "org": "College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518000, PR China"
            },
            {
                "name": "Kai Wang",
                "org": ""
            },
            {
                "name": "Zhongkuan Luo",
                "org": ""
            }
        ],
        "venue": "Dyes and Pigments",
        "year": 2018
    },
    "EGfWA1Xp": {
        "id": "EGfWA1Xp",
        "title": "Halide-Rich Synthesized Cesium Lead Bromide Perovskite Nanocrystals for Light-Emitting Diodes with Improved Performance",
        "abstract": "To improve the quality and durability of inorganic halide perovskite nanocrystals (NCs), ammonium halide and lead oxide (PbO) were separately employed for the synthesis of NCs with a tunable ratio of metal to halide. The halide-rich circumstance was therefore successfully set up and found to be beneficial for obtaining good quality NCs with high photoluminescence quantum yields and remarkable stability against purification compared to those qualities of previous regular methods with lead halide. The fabricated light-emitting diode (LED) devices with NCs made in a halide-rich circumstance demonstrated performance better than that of devices with NCs made in a halide-poor circumstance. A LED with CsPbBr3 NCs with a 1:4 Pb:Br ratio showed an obvious improved maximal luminance of 12090 cd m\u20132, a current efficiency of 3.1 cd A\u20131, and an external quantum efficiency of 1.194%, which were much higher than those of devices with NCs synthesized by the regular method.",
        "keywords": "",
        "authors": [
            {
                "name": "Peizhao Liu",
                "org": ""
            },
            {
                "name": "Wei Chen",
                "org": ""
            },
            {
                "name": "Weigao Wang",
                "org": ""
            },
            {
                "name": "Bing Xu",
                "org": ""
            },
            {
                "name": "Dan Wu",
                "org": ""
            },
            {
                "name": "Junjie Hao",
                "org": ""
            },
            {
                "name": "Wanyu Cao",
                "org": ""
            },
            {
                "name": "Fan Fang",
                "org": ""
            },
            {
                "name": "Yang Li",
                "org": ""
            },
            {
                "name": "Yuanyuan Zeng",
                "org": ""
            },
            {
                "name": "Ruikun Pan",
                "org": ""
            },
            {
                "name": "Shuming Chen",
                "org": ""
            },
            {
                "name": "Wanqiang Cao",
                "org": ""
            },
            {
                "name": "Xiao Wei Sun",
                "org": ""
            },
            {
                "name": "Kai Wang",
                "org": ""
            }
        ],
        "venue": "Chemistry of Materials",
        "year": 2017
    },
    "xir5kt3Z": {
        "authors": [
            {
                "name": "Z. Wu",
                "org": "National Field Station of Freshwater Ecosystem of Liangzi Lake, College of Life Sciences, Wuhan University"
            },
            {
                "name": "Z. Ding",
                "org": "National Field Station of Freshwater Ecosystem of Liangzi Lake, College of Life Sciences, Wuhan University"
            },
            {
                "name": "D. Yu",
                "org": "College of Life Sciences, Wuhan University"
            },
            {
                "name": "X. Xu",
                "org": "National Field Station of Freshwater Ecosystem of Liangzi Lake, College of Life Sciences, Wuhan University"
            }
        ],
        "title": "Influence of niche similarity on hybridization between Myriophyllum sibiricum and M. spicatum",
        "abstract": "The impact of ecological factors on natural hybridization is of widespread interest. Here, we asked whether climate niche influences hybridization between the two closely related plant species Myriophyllum sibiricum and M. spicatum. Eight microsatellite loci and two chloroplast fragments were used to investigate the occurrence of hybridization between these two species in two co-occurring regions: north-east China (NEC) and the Qinghai-Tibetan Plateau (QTP). The climate niches of the species were quantified by principal component analysis with bioclimatic data, and niche comparisons were performed between the two species in each region. Reciprocal hybridization was observed, and M. sibiricum was favoured as the maternal species. Furthermore, hybrids were rare in NEC but common in the QTP. Accordingly, in NEC, the two species were climatically distinct, and hybrids only occurred in the narrow geographical or ecological transition zone, whereas in the QTP, obvious niche overlaps were found for the two species, and hybrids occurred in multiple contact zones. This association between hybridization pattern and climate niche similarity suggests that the level of hybridization was promoted by niche overlap. Compared with the parental species, similar climate niches were found for the hybrid populations in the QTP, indicating that other environmental factors rather than climate were important for hybrid persistence. Our findings highlight the significance of climate niche with respect to hybridization patterns in plants.",
        "keywords": [
            "Myriophyllum",
            "Climate niche",
            "Hybridization",
            "Niche overlap",
            "Niche similarity",
            "North-east China",
            "Qinghai-Tibetan Plateau"
        ],
        "venue": "Journal of Evolutionary Biology",
        "year": 2015,
        "id": "xir5kt3Z"
    },
    "PiR8hKAN": {
        "authors": [
            {
                "name": "Li Ma",
                "org": "School OfTraditional Chinese Medicine"
            },
            {
                "name": "Lin Ma",
                "org": "Pharmacy College"
            },
            {
                "name": "Shu-Bin Wang",
                "org": "Yi-ling Medical Institute"
            },
            {
                "name": "Xuan Wang",
                "org": "School OfTraditional Chinese Medicine"
            },
            {
                "name": "Lin Yue",
                "org": "School OfTraditional Chinese Medicine"
            }
        ],
        "title": "Review on scientific connotation of leech processed under high temperature",
        "keywords": [
            "Animal medicine",
            "Chinese medicine leech",
            "Processing under high temperature",
            "Scientific rationality"
        ],
        "venue": "Zhongguo Zhongyao Zazhi",
        "year": 2015,
        "id": "PiR8hKAN"
    },
    "VRh5ggIn": {
        "id": "VRh5ggIn",
        "title": "Effects of rapid entrance into plateau area on the vascular endothelial function and the relationship to acute mountain sickness",
        "abstract": "Objective\u3000To observe the changes in the vascular endothelial function indexes in subjects who enter plateau areas expeditiously, and investigate the relationship between their changes and acute mountain sickness (AMS). Methods\u3000Thirty-two healthy young male lowlands residents were recruited as subjects, and they were sent by bus to an area of altitude of 3900m. According to the score of Lake Louise questionnaire, the subjects were divided into AMS+ and AMS\u2013 group at the 5th day after the entrance into plateau. The changes in the vascular endothelial function indexes (NO, ET-1, VEGF, VE-cadherin, MDA and SOD) in serum of the subjects were detected by ELISA. Pearson correlation analysis was performed to identify the relationship of AMS to the changes of the indexes mentioned above. Results\u3000On the 5th day after being exposed to high altitude, the incidence of AMS was 43.8% (14/32). The serum levels of NO and SOD in subjects were significantly lowered (Pu003c0.05 and Pu003c0.01, respectively) compared with those before the entrance into high altitude area, while the levels of ET-1 and MDA were obviously elevated (Pu003c0.05). However, the levels of VEGF and VE-cadherin showed no obvious change in the subjects as compared before and after the entrance into plateau area. After the entrance into the plateau, the levels of NO, VEGF, VE-cadherin and SOD were lowered obviously and ET-1 level increased significantly in AMS+ group as compared with those in AMS\u2012 group (Pu003c0.05 and Pu003c0.01, respectively). Correlation analysis showed that the serum levels of NO, VEGF, VE-cadherin and SOD were negatively correlated with AMS after a 5-day high altitude exposure, while serum level of ET-1 was positively correlated with AMS. Conclusions\u3000Rapid entrance into plateau area may induce damage to vascular endothelial function of the subjects, and it affects the serum levels of NO, ET-1, VEGF, VE-cadherin and SOD. The changes in these indexes may provide the potential basis for prewarning and diagnosis of AMS.    DOI: 10.11855/j.issn.0577-7402.2015.05.18",
        "keywords": "",
        "authors": [
            {
                "name": "Youzhu Qiu",
                "org": ""
            },
            {
                "name": "Jie Yu",
                "org": ""
            },
            {
                "name": "Lianyou Wang",
                "org": ""
            },
            {
                "name": "Xiao Liang",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "En-hao Zhang",
                "org": ""
            },
            {
                "name": "Lan Huang",
                "org": ""
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2015
    },
    "aRIH1J0j": {
        "id": "aRIH1J0j",
        "title": "PACS2 is required for ox-LDL-induced endothelial cell apoptosis by regulating mitochondria-associated ER membrane formation and mitochondrial Ca 2+ elevation.",
        "abstract": "Oxidized low-density lipoprotein (ox-LDL)-induced endothelial cell (EC) apoptosis is the initial step of atherogenesis and associated with Ca overload. Mitochondria-associated endoplasmic reticulum (ER) membrane (MAM), regulated by tethering proteins such as phosphofurin acidic cluster sorting protein 2 (PACS2), is essential for mitochondrial Ca overload by mediating ER-mitochondria Ca transfer. In our study, we aimed to investigate the role of PACS2 in ox-LDL-induced apoptosis in human umbilical vein endothelial cells (HUVECs) and the underlying mechanisms. Ox-LDL dose- and time-dependently increased cell apoptosis concomitant with mitochondrial Ca elevation, mitochondrial membrane potential (MMP) loss, reactive oxygen species (ROS) production, and cytochrome c release. Silencing PACS2 significantly inhibited ox-LDL-induced cell apoptosis at 24\u202fh in addition to the effects of ox-LDL on mitochondrial Ca, MMP, and ROS at 2\u202fh. Besides, ox-LDL promoted PACS2 localization at mitochondria as well as ER-mitochondria contacts at 2\u202fh. Not only that, ox-LDL upregulated PACS2 expression at 24\u202fh. Furthermore, silencing PACS2 inhibited ox-LDL-induced mitochondrial localization of PACS2 and MAM formation at 24\u202fh. Altogether, our findings suggest that PACS2 plays an important role in ox-LDL-induced EC apoptosis by regulating MAM formation and mitochondrial Ca elevation, implicating that PACS2 may be a promising therapeutic target for atherosclerosis.",
        "keywords": [
            "Atherosclerosis",
            "Calcium",
            "Endothelial cell apoptosis",
            "Mitochondria-associated ER membrane",
            "Mitochondrial dysfunction",
            "PACS2"
        ],
        "authors": [
            {
                "name": "Sanjiu Yu",
                "org": "Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address: sanjiuyu09@163.com."
            },
            {
                "name": "Laiping Zhang",
                "org": "Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address: laipingzhang@163.com."
            },
            {
                "name": "Chuan Liu",
                "org": "Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address: liuchuan19821207@163.com."
            },
            {
                "name": "Jie Yang",
                "org": "Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address: yangjie0818@hotmail.com."
            },
            {
                "name": "Jihang Zhang",
                "org": "Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address: zhang.zjh@qq.com."
            },
            {
                "name": "Lan Huang",
                "org": "Institute of Cardiovascular Diseases, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing, China. Electronic address: haunglan260@126.com."
            }
        ],
        "venue": "Experimental cell research",
        "year": 2019
    },
    "5WtyXPuW": {
        "id": "5WtyXPuW",
        "title": "Store-operated calcium entry-activated autophagy protects EPC proliferation via the CAMKK2-MTOR pathway in ox-LDL exposure.",
        "abstract": "Improving biological functions of endothelial progenitor cells (EPCs) is beneficial to maintaining endothelium homeostasis and promoting vascular re-endothelialization. Because macroautophagy/autophagy has been documented as a double-edged sword in cell functions, its effects on EPCs remain to be elucidated. This study was designed to explore the role and molecular mechanisms of store-operated calcium entry (SOCE)-activated autophagy in proliferation of EPCs under hypercholesterolemia. We employed oxidized low-density lipoprotein (ox-LDL) to mimic hypercholesterolemia in bone marrow-derived EPCs from rat. Ox-LDL dose-dependently activated autophagy flux, while inhibiting EPC proliferation. Importantly, inhibition of autophagy either by silencing Atg7 or by 3-methyladenine treatment, further aggravated proliferative inhibition by ox-LDL, suggesting the protective effects of autophagy against ox-LDL. Interestingly, ox-LDL increased STIM1 expression and intracellular Ca concentration. Either Ca chelators or deficiency in STIM1 attenuated ox-LDL-induced autophagy activation, confirming the involvement of SOCE in the process. Furthermore, CAMKK2 (calcium/calmodulin-dependent protein kinase kinase 2, \u03b2) activation and MTOR (mechanistic target of rapamycin [serine/threonine kinase]) deactivation were associated with autophagy modulation. Together, our results reveal a novel signaling pathway of SOCE-CAMKK2 in the regulation of autophagy and offer new insights into the important roles of autophagy in maintaining proliferation and promoting the survival capability of EPCs. This may be beneficial to improving EPC transplantation efficacy and enhancing vascular re-endothelialization in patients with hypercholesterolemia.",
        "keywords": [
            "CAMKK2",
            "MTOR",
            "autophagy",
            "cell-based therapy",
            "endothelial progenitor cells",
            "oxidized low-density lipoprotein",
            "proliferation",
            "store-operated calcium entry"
        ],
        "authors": [
            {
                "name": "Jie Yang",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Jie Yu",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Dongdong Li",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Sanjiu Yu",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Jingbin Ke",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Lianyou Wang",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Yanwei Wang",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Youzhu Qiu",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Xubin Gao",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Jihang Zhang",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            },
            {
                "name": "Lan Huang",
                "org": "a Institute of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University , Chongqing , China."
            }
        ],
        "venue": "Autophagy",
        "year": 2017
    },
    "NM7CLIcU": {
        "id": "NM7CLIcU",
        "title": "Effects of autophagy on cell migration and apoptosis of endothelial progenitor cells in hypoxic environment",
        "abstract": "Objective  To investigate the effects of autophagy on cell migration and apoptosis of endothelial progenitor cells (EPCs) in hypoxic environment. Methods  Ratsu0027 bone marrow-derived EPCs were isolated by density-gradient centrifugation, identified with double-fluorescent staining method, and then divided into 4 groups: normoxia (hypoxia 0h), hypoxia 1h, hypoxia 3h and hypoxia 6h groups for detecting the effects of hypoxia on EPCs migration and apoptosis. Transwell chambers and flow cytometry were used to detect cell migration and apoptosis respectively, and Western blotting was performed to detect the changes of autophagy-related proteins, including microtubule associated protein 1 light chain 3 (LC3-?/?) and ubiquitin of p62. To investigate the effects of hypoxic-induced autophagy on EPCs migration and apoptosis, cells were divided into 4 groups: hypoxia 0h, hypoxia 3h, hypoxia 3h+ShAtg7 and ShAtg7 groups, and then to detect again the EPCs migration and apoptosis. Results  Compared to hypoxia 0h group, the EPCs migration markedly reduced and apoptosis increased in hypoxic 3h and 6h groups with statistically significant difference (Pu003c0.05). Western blotting showed the expressions of LC3-?/? significantly increased and of p62 decreased in EPCs by hypoxic treatment for 3 and 6 hours (Pu003c0.05), implying the increases of autophagy level. After inhibiting autophagy by silencing Atg7, hypoxia 3h+ShAtg7 group further reduced EPCs migration (Pu003c0.05) and aggravated apoptosis (Pu003c0.05) compared with hypoxia 3h group. Conclusion  Autophagy may play a cytoprotective role through promoting EPCs migration and decreasing EPCs apoptosis in hypoxic environment.    DOI: 10.11855/j.issn.0577-7402.2018.04.10",
        "keywords": "",
        "authors": [
            {
                "name": "Sen Yu",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Ji-hang Zhang",
                "org": ""
            },
            {
                "name": "Lan Huang",
                "org": ""
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2018
    },
    "PNoHPSvZ": {
        "id": "PNoHPSvZ",
        "title": "PPARA genetic variants increase the risk for cardiac pumping function reductions following acute high-altitude exposure: A self-controlled study.",
        "abstract": "This self-controlled study revealed that PPARA variations significantly increased the risk for cardiac pumping function reductions following acute high-altitude exposure, providing a potential predictive marker before high-altitude exposure and targets in mechanistic studies.",
        "keywords": [
            "\nPPARA\n",
            "cardiac function",
            "genotype-phenotype correlation",
            "haplotypes",
            "high altitude"
        ],
        "authors": [
            {
                "name": "Jie Yang",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Chuan Liu",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Zhang Jihang",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Jie Yu",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Limeng Dai",
                "org": "Department of Medical Genetics, College of Basic Medical Science, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Xiaohan Ding",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Youzhu Qiu",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Sanjiu Yu",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Yuanqi Yang",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Yuzhang Wu",
                "org": "Institute of Immunology, Army Medical University (Third Military Medical University), Chongqing, PR China."
            },
            {
                "name": "Lan Huang",
                "org": "Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, PR China."
            }
        ],
        "venue": "Molecular genetics & genomic medicine",
        "year": 2019
    },
    "E8fO2YNv": {
        "id": "E8fO2YNv",
        "title": "C/EBP\u03b2 Acts Upstream of NF-\u03baB P65 Subunit in Ox-LDL-Induced IL-1\u03b2 Production by Macrophages.",
        "abstract": "Our results demonstrate that C/EBP\u03b2 acts upstream of NF-\u03baB p65 subunit in ox-LDL-induced IL-1\u03b2 production in macrophages and may regulate IL-1\u03b2 maturation by promoting caspase-1. C/EBP\u03b2 may be a promising candidate for the prevention and treatment of atherosclerosis.",
        "keywords": [
            "Atherosclerosis",
            "C/EBP\u03b2",
            "IL-1\u03b2",
            "Inflammation",
            "NF-\u03baB",
            "Ox-LDL"
        ],
        "authors": [
            {
                "name": "Jun Ma",
                "org": ""
            },
            {
                "name": "Chuan Liu",
                "org": ""
            },
            {
                "name": "Yuanqi Yang",
                "org": ""
            },
            {
                "name": "Jie Yu",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Sanjiu Yu",
                "org": ""
            },
            {
                "name": "Jihang Zhang",
                "org": ""
            },
            {
                "name": "Lan Huang",
                "org": ""
            }
        ],
        "venue": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology",
        "year": 2018
    },
    "P8CpeKVt": {
        "id": "P8CpeKVt",
        "title": "DNMT1-PPAR\u03b3 pathway in macrophages regulates chronic inflammation and atherosclerosis development in mice",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Yu",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Youzhu Qiu",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Jie Yang",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Shizhu Bian",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Guozhu Chen",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Mengyang Deng",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Huali Kang",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            },
            {
                "name": "Lan Huang",
                "org": "Institute of Cardiovascular Diseases of the PLA , Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "n9IK3MHp": {
        "id": "n9IK3MHp",
        "title": "Oral zolpidem prevents acute mountain sickness: a randomized double-blind placebo controlled study",
        "abstract": "Objective\u3000To study the prophylactic effect of zolpidem on acute mountain sickness (AMS) after acute high-altitude exposure. Methods\u3000A randomized double-blind placebo controlled trial was performed on the plateau. Forty subjects were randomly divided into zolpidem group and placebo group. The general clinical data, heart rate, blood pressure, oxygen saturation, the Pittsburgh Sleep Quality Index (PSQI) scores, AMS scores and physical fitness test of the both groups were collected and assessed on plain and plateau, respectively. Results\u3000The PSQI scores were obviously lower and the six-minute walk distance was significantly longer in zolpidem group than those in placebo group (P=0.047 and P=0.009, respectively) after acute high-altitude exposure. AMS incidence was significantly lower in zolpidem group than in placebo group at different time points (P=0.019, 0.014, 0.025 and 0.026, respectively), and the incidence of severe AMS was also significantly lower in zolpidem group than in placebo group at different time points (P=0.047, 0.044, 0.031 and 0.020, respectively). The symptoms of dizziness, weakness and fatigue were significantly lighter in zolpidem group than in placebo group after acute exposure to high-altitude exposure for 20 hours (P 0.05). Conclusion\u3000Zolpidem may alleviate AMS symptoms and reduce the incidence of AMS, so it may be promising as a new choice for the prevention of AMS.    DOI: 10.11855/j.issn.0577-7402.2015.09.09",
        "keywords": "",
        "authors": [
            {
                "name": "Yong-tao Huang",
                "org": ""
            },
            {
                "name": "Jun Qin",
                "org": ""
            },
            {
                "name": "Xu-bin Gao",
                "org": ""
            },
            {
                "name": "Guozhu Chen",
                "org": ""
            },
            {
                "name": "Cheng-Rong Zheng",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Lan Huang",
                "org": ""
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2015
    },
    "Zkq6WcFY": {
        "id": "Zkq6WcFY",
        "title": "Influence of acute high altitude exposure and short-term acclimation on platelet-associated parameters in healthy young man",
        "abstract": "Objective  To explore the effect of high altitude exposure and short-term acclimation on the platelet-associated parameters by studying the changes of platelet-associated parameters in healthy young man. Methods  Four hundred and sixty- two young men were recruited from Chengdu (the elevation of 500m) during Jun. 2012 to Aug. 2013 according to the inclusion and exclusion criteria, of which 193 had been living in Chengdu (plain group), and 269 flew from Chengdu to Lhasa (3700m) in 2 hours,  and then 147 of them were exposed in the high altitude for 1 day (acute high altitude exposure group), and another 122 for 7 days (short-term acclimation group). The demographic data were collected and the blood routine and platelet-associated parameters were measured of all the participants, and then the information collected were compared between the 3 groups. Results  Compared to the plain group, the platelet count (PLT), platelet distribution width (PDW) and plateletcrit (PCT) reduced and the mean platelet volume (MPV) increased significantly (P 0.05). Pearson correlation analysis indicated that high altitude-induced reduction of oxygen saturation (SpO2) was positively related to the changes of PLT. Conclusions  Acute high altitude exposure may reduce PLT, PDW and PCT levels, but elevate MPV and enhance the platelet activity. The reduction of SpO2 might be associated with the changes of PLT, PDW and PCT. Platelet-associated parameters may be recovered to normal with a compensatory effect after short-term acclimation.    DOI: 10.11855/j.issn.0577-7402.2018.03.13",
        "keywords": "",
        "authors": [
            {
                "name": "Jing-bin Ke",
                "org": ""
            },
            {
                "name": "Jia-bei Li",
                "org": ""
            },
            {
                "name": "Ji-hang Zhang",
                "org": ""
            },
            {
                "name": "Shi-Zhu Bian",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Chuan Liu",
                "org": ""
            },
            {
                "name": "Can Chen",
                "org": ""
            },
            {
                "name": "Chen Zhang",
                "org": ""
            },
            {
                "name": "Jie Yu",
                "org": ""
            },
            {
                "name": "Jun Jin",
                "org": ""
            },
            {
                "name": "Lan Huang",
                "org": ""
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2018
    },
    "y2gLEudE": {
        "id": "y2gLEudE",
        "title": "Heart Failure Duration Combined with Left Atrial Dimension Predicts Super-Response and Long-Term Prognosis in Patients with Cardiac Resynchronization Therapy Implantation.",
        "abstract": "HF duration, LAD, and LBBB independently predicted super-response. The combination of HF duration and LAD makes more robust prediction of CRT super-response. Super-responders had excellent LV reverse remodeling and decreased the incidences of the combined end point. LBBB and LAD were independently associated with the combined end point.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhinian Guo",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Xiaoyan Liu",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Chuan Liu",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Jie Yang",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Xiaofeng Cheng",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Yunlong Chen",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Ping Li",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Yongming He",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            },
            {
                "name": "Jiang Wang",
                "org": "Department of Cardiology, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Street, Chongqing 400037, China."
            }
        ],
        "venue": "BioMed research international",
        "year": 2019
    },
    "WbGcQ00n": {
        "authors": [
            {
                "name": "Y.Q. Ning",
                "org": "School of Materials Science and Engineering, Northwestern Polytechnical University"
            },
            {
                "name": "T. Wang",
                "org": "Science and Technology on Advanced High Temperature Structural Materials Laboratory, Beijing Institute of Aeronautical Materials"
            },
            {
                "name": "M.W. Fu",
                "org": "Department of Mechanical Engineering, The Hong Kong Polytechnic University"
            },
            {
                "name": "M.Z. Li",
                "org": "School of Materials Science and Engineering, Northwestern Polytechnical University"
            },
            {
                "name": "L. Wang",
                "org": "School of Materials Science and Engineering, Northwestern Polytechnical University"
            },
            {
                "name": "C.D. Zhao",
                "org": "School of Materials Science and Engineering, Northwestern Polytechnical University"
            }
        ],
        "title": "Competition between work-hardening effect and dynamic-softening behavior for processing as-cast GH4720Li superalloys with original dendrite microstructure during moderate-speed hot compression",
        "abstract": "Competition between work-hardening effect and dynamic-softening behavior of as-cast GH4720Li superalloys with original dendrite microstructure during moderate-speed deformation was quantitatively investigated in this present paper. Flow behavior for processing the studied alloys with dendrite microstructure behaves typical three stages, caused by the competition effect between work-hardening and dynamic-softening. The relationships between work-hardening rate and true strain and true stress were derived from Kocks-Mecking dislocation relation. The work-hardening effect shows two obvious stages with strain, viz. steady fluctuations and linear decreasing. An obvious work-hardening effect was demonstrated under lower temperature and higher strain rate. The linear relationship of work-hardening rate \u03b8 on true stress \u03b5 was constructed with the slope only related to annihilation coefficient \u03a9. The microstructural mechanism of as-cast GH4720Li superalloys during moderate-speed deformation was referred to dislocation multiplication and dendrite fragmentation, and the latter was beneficial to dynamic recrystallization during moderate-speed deformation.",
        "keywords": [
            "Dislocation",
            "Dynamic-softening (DS)",
            "GH4720Li superalloys",
            "Hot deformation",
            "Microstructural mechanism",
            "Work-hardening (WH)"
        ],
        "venue": "Materials Science and Engineering A",
        "year": 2015,
        "id": "WbGcQ00n"
    },
    "A7Zbzt0n": {
        "id": "A7Zbzt0n",
        "title": "Comparison of clinical effect of transurethral resection and bipolar plasma kinetic resection of benign prostatic hyperplasia",
        "abstract": "Objective To compare the shor-term clinical efficacy,safety and complications of bipolar plasma kinetic resection of prostate(PKRP)and transurethral resection of prostate(TURP)for treatment of benign prostatic hyperplasia(BPH).Methods 146 pa-tients with BPH were randomly divided into two groups underwent PKRP and TURP respectively.Before the operation,there were no significant diferences in international prostate symptom score(IPSS),quality of life(QQL),residual urine volume(RUV)and the maximal urinary flow rate(Qmax)between the two groups(P>0.05).The clinical parameters before and after operation were compared.Results The change of the operative time postoperative hemoglobin,differences between the preoperative and postoperative serum sodium concentrations were significantl(P<0.01).Following-up at 3 and 6 months after the operation showed that IPSS,QQL and RUV scores increased and Qmax scores decreased among the two groups compared with those before the operation,with no significant differences between the two groups(P>0.05).There were no significant differences in bladder washout and postoperative catheterization between the two groups(P>0.05).The incidence of complications was 27.3%,and 8.2% in TURP and PKRP groups respectively.Conclusions PKRP and TURP have similar short-term eficacy in the treatment of BPH,but PKRP is safer and less complications than TURP.",
        "keywords": [
            "Transurethral plasmakinetic resection of the prostate",
            "Benign prostatic hyperplasia",
            "Transurethral resection of the prostate"
        ],
        "authors": [
            {
                "name": "MEI Hong-bing",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            },
            {
                "name": "WANG Feng",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            },
            {
                "name": "CHANG Jiang-ping",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            },
            {
                "name": "SHI Ming",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            },
            {
                "name": "YE Shao-bo",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            },
            {
                "name": "ZENG Shao-ming",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            },
            {
                "name": "WU Feng",
                "org": ",ZHENG Xing-tao,CHEN Jian-li.Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen ,China"
            }
        ],
        "venue": "Chinese Journal of Endourology(Electronic Edition)",
        "year": 2010
    },
    "vXDKyVM0": {
        "id": "vXDKyVM0",
        "title": "A Comparative Study of Immediately Intravesical Instillation of Pirarubicin Combined with Conventional Intravesical Instillation for Preventing Postoperative Recurrence of Superficial Bladder Cancer",
        "abstract": "Objective:To Compare the efficacy and safety of intravesical instillation of pirarubicin (THP) to prevent the post\u2014operative recurrence of superficial bladder cancer with two different methods. Methods: A total of 52 cases of superficial bladder cancer after transurethral resection (TURBT) were randomly divided into two groups. Each infusion dose of THP is 30 mg. The treatment group was given within 24 hours after operation, then was given once a week for 8 weeks. And then was given once a month to 1 year after operation. The control group was given after 2 week of operation, then was given once a week for 8 weeks. And then was given once a month to 1 year after operation. Results: All cases received 12\u201424 months follow\u2014up, with an average follow-up of 16. 3 months. In treatment group ,2 patients recurred during the follow-up period, the recurrence rate was 8% , in the control group, 4 cases recurred, the recurrence rate was 14%. Adverse reactions were mainly urinary tract irritation. Conclusions:This study shows that intravesical instillation of THP was an efficient, convenient, well tolerated method to prevent recurrence of superficial bladder cancer. Immediately intravesical instillation of THP after operation and combined with conventional intravesical instillation can reduce the tumor recurrence rate compared with conventional way alone,it is worth recommending.",
        "keywords": [
            "superficial bladder cancer",
            "intravesical instillation",
            "pirarubicin (THP)"
        ],
        "authors": [
            {
                "name": "Hongbing MEI",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Feng WANG",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Jiangping CHANG",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Zhonglin ZHANG",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Ming SHI",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Shaobo YE",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Wanhua ZHEN",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Shaoming ZENG",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Feng WU",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Xintao ZHANG",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            },
            {
                "name": "Jianli CHENG",
                "org": "1 Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen, Guangdong, , China"
            }
        ],
        "venue": "Journal of Clinical Urology",
        "year": 2010
    },
    "JiICckvz": {
        "id": "JiICckvz",
        "title": "Crushing Treatment of Cystolith with Pressure Bullet under Ureteroscope via Resectoscope Trocar",
        "abstract": "Objective To discuss the new method and curative effect of crushing treatment of cystolith with pressure bullet under ureteroscope via resectoscope trocar.Methods The cystolith was crushed with pressure bullet under ureteroscope via resectoscope trocar and prostate resection was performed in 12 cases with hyperplasia of prostate same time.Results 36 cases had cured at first time in crushing stone and excretion without bleeding,bladder perforation and overhydration.There was no relapse after 6\uff5e24 months follow-up without obstruction.Conclusion This method might be effective with simple,less complication and good effect that could be used in clinic.",
        "keywords": [
            "Cystolith",
            "Resectoscope",
            "Pressure bullet crushing stone"
        ],
        "authors": [
            {
                "name": "WU Feng",
                "org": "Department of Urology,The Second People's Hospital of Shenzhen City,Shenzhen ,China"
            },
            {
                "name": "WANG Feng",
                "org": "Department of Urology,The Second People's Hospital of Shenzhen City,Shenzhen ,China"
            },
            {
                "name": "CHANG Jiang-ping",
                "org": "Department of Urology,The Second People's Hospital of Shenzhen City,Shenzhen ,China"
            }
        ],
        "venue": "Heilongjiang Medical Journal",
        "year": 2007
    },
    "dcr0sgrz": {
        "id": "dcr0sgrz",
        "title": "Evaluation of Detrusor Function and Predicting the Surgical Outcome for Cases of Benign Prostatic Hyperplasia Associated with Acute Urinary Retention",
        "abstract": "Objective To evaluation the detrusor function for cases of benign prostatic hyperplasia(BPH) associated with acute Urinary retention(AUR),predicting the surgical outcome.Methods Urodynamic paramenters were analyzed preoperatively and postoperatively in 23 cases of BPH associated with AUR,evaluation of detrusor function(include detrusor stability,compliance,contractile function).These paramenters were compared between successful and failed treatment groups.Results Among the 23 cases of BPH associated with AUR,detrusor instability(DI) was found in 16 cases(69.6%),the amplitude of DI was (98\u00b133) (5\uff5e168)cmH2O.Voluntary detrusor contractions were seen in 19 cases (82.6%).Bladder outlet obstruction(BOO) was diagnosed definilely in all cases.Four cases (17.4%) failed to void after operation and required catheterization.There were significant differences (P>0.05) between 2 groups regarding ago,DI,detursor compliance,cystometric bladder capacity,and contractility of detrusor muscle.Conclusion For BPH patients with AUR,pressure-flow studies undertaken with 10 days after retention are useful in predicting the surgical outcome.The higher amplitude of DI the stronger the contractility of the detrusor muscle and the better the postoperative results.The increase of detrusor compliance and cystometric bladder capacity and absence of DI are possible associated with a poor outcome after operation.",
        "keywords": [
            "Acute urinary retention",
            "Urodynamics",
            "Benign prostatic hyperplasia",
            "Detrusor",
            "Urinary retention",
            "Prostatic hyperplasia"
        ],
        "authors": [
            {
                "name": "WU Feng",
                "org": "Department of Urology, The Second People's Hospital of Shenzhen City, Shenzhen , China"
            },
            {
                "name": "WANG Feng",
                "org": "Department of Urology, The Second People's Hospital of Shenzhen City, Shenzhen , China"
            },
            {
                "name": "ZHANG Wei",
                "org": "Department of Urology, The Second People's Hospital of Shenzhen City, Shenzhen , China"
            }
        ],
        "venue": "Heilongjiang Medical Journal",
        "year": 2007
    },
    "dGlUXohB": {
        "id": "dGlUXohB",
        "title": "Treatment of ureteral calculi with ballistic lithoclast]",
        "abstract": "To evaluate the availability of ballistic lithoclast in treatment of ureteral calculi.Totally 625 patients with ureteral calculi were treated with ballistic lithoclast by rigid ureteroscopy.Totally 610 patients were treated successfully by ballistic lithoclast with a cure rate of 97.6% (90.3% in upper ureter, 96.8% in middle ureter, 100% in lower ureter). The average time of lithoclast was (5.0 +/- 2.8) minutes and the stone-free rate was 99.2%.Ballistic lithoclast combined with rigid ureteroscopy is safe and effective in treating ureteral calculi.",
        "keywords": [],
        "authors": [
            {
                "name": "Zeng Shao-ming",
                "org": "Department of Urology, the Second People's Hospital of Shenzhen, Shenzhen 518035, China. zengshaoming@21cn.com"
            },
            {
                "name": "Chang Jiang-ping",
                "org": ""
            },
            {
                "name": "Wang Feng",
                "org": ""
            },
            {
                "name": "Wu Feng",
                "org": ""
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2005
    },
    "VN6TwO4Q": {
        "id": "VN6TwO4Q",
        "title": "Applied anatomoclinica on retroperitoneoscopic adrenalectomy for the treatment of adrenal tumors",
        "abstract": "\u3010Objective\u3011To discuss application of clinical anatomy of retroperitoneoscopic adrenalectomy for the treatment of adrenal tumors. \u3010Methods\u3011Using three relatively bloodless planes existing retroperitoneal space in retroperitoneoscopic adrenalectomy,treatment effectiveness and recovery of 57 cases was analyzed. \u3010Results\u3011Among the cases,2 cases were converted to open surgery,55 cases operations were successful. Operation time was 55 min to 2.5 h,with an average of 68 min. Mean hospital days after operation were 5.5. \u3010Conclusion\u3011Retroperitoneoscopic adrenalectomy is indicated for hormonally active adrenal tumors,incidentaloma and limited malignant adrenal carcinomas,thus with advantages of clear field,minimal morbidity,minimal postoperative discomfort.",
        "keywords": [
            "anatomy",
            "adrenal tumors",
            "retroperitoneoscopic"
        ],
        "authors": [
            {
                "name": "MEI Hong-bing",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "WANG Feng",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "CHANG Jiang-ping",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "ZHANG Zhong-lin",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "SHI Ming",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "YE Shao-bo",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "ZENG Shao-ming",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "WU Feng",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "ZHANG Xin-tao",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            },
            {
                "name": "CHENG Jian-li",
                "org": "Department of Urology,the Second People's Hospital of Shenzhen,Shenzhen,Guangdong ,P.R.China"
            }
        ],
        "venue": "China Journal of Endoscopy",
        "year": 2010
    },
    "YBWrO9HB": {
        "id": "YBWrO9HB",
        "title": "Study on the Effect of Tedenan on Prostatic Hyperplasia Combined with Detrusor Instability",
        "abstract": "Objective To explove the effect of Tedenan on the BPH combined with DI by means of urodynamics.(Methods 75 patients) with BPH were randomized into treatment group(39 cases)and control group(36 cases).Treatment group used tedenan 25 mg two times per day and control group used two Zeguilongshuang capsules three times per day for six weeks.Urodynamics check was used for treatmeat during such as maximum flow rate(Qmax),maximum detrusor pressure of storage urinary time(Pdet.max),constant volume maximum detrusor pressure of urination(Pdet.cons),maxmum urethral closure pressure(PUCP),functional urethral Length(FUL).Results Treatment group:Pdet.max of storage urinary time that was significant difference in(P<0.01),it reduce compared Pdet.max with control group(5.54\u00b11.15)cmH_2O;constant volume detrusor contract pressure of urination that was significant difference in the treatment(P<0.01),it increased comparing Pdet.cons with control group(22.61\u00b14.61)cmH_2O.control group:Pdet.max of storage urinary time and Pdet.cons of urination there was no statistical absorption coefficient(P>0.05).Conclusions Tedenan is an avail drug in treating benign prostatic hyperplasia combined with detrusor instability.",
        "keywords": [
            "BPH",
            "Tedenan",
            "Urodynamics",
            "DI"
        ],
        "authors": [
            {
                "name": "YE Shao-bo",
                "org": ",et al.Department of Urology,The Second People's Hospital of Shenzhen,Guangdong ,China"
            },
            {
                "name": "SHI Ming",
                "org": ",et al.Department of Urology,The Second People's Hospital of Shenzhen,Guangdong ,China"
            },
            {
                "name": "WU Feng",
                "org": ",et al.Department of Urology,The Second People's Hospital of Shenzhen,Guangdong ,China"
            }
        ],
        "venue": "Chinese Journal of Natural Medicine",
        "year": 2006
    },
    "VYi3FMzU": {
        "id": "VYi3FMzU",
        "title": "Study on Extracting Process and Preparation of Qianlietong Tablet",
        "abstract": "Objective:To study the optimum extracting process and preparation of Qianlietong tablet. Methods:The proper extracting conditions are optimized by orthogonal tests with the amount of extracted chlorogenic acid as index. Results:The proper decocting condition: the proper extracting condition with water: the herbsare extracted with 6, 4 and 4 times for 3 times while 1 hours each time. Conclusion: Optimized process condition is scientific, stable and practicable in manufacture",
        "keywords": [
            "HPLC",
            "chlorogenic acid",
            "extraction processes",
            "preparation process",
            "orthogonal tests"
        ],
        "authors": [
            {
                "name": "Li Ruihai",
                "org": "Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China"
            },
            {
                "name": "Cheng Lan",
                "org": "Liaoning Chengda Fangyuan MedicalLinkage Co.LTD,Shenyang ,Liaoning,China"
            },
            {
                "name": "Zhao Lin",
                "org": "Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China"
            },
            {
                "name": "Lv Jia",
                "org": "Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China"
            },
            {
                "name": "Chen Cuiying",
                "org": "Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China"
            },
            {
                "name": "Chen Jianfeng",
                "org": "Liaoning Chengda Fangyuan MedicalLinkage Co.LTD,Shenyang ,Liaoning,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2006
    },
    "EnrTakQU": {
        "id": "EnrTakQU",
        "title": "Determination of Tetrandrine in Xixian Fengshi Tablet by RP-HPLC",
        "abstract": "Objective: To establish HPLC for determining the content of tetrandrine in Xixian Fengshi tablet.Method:An HPLC method was developed.The chromatographic conditions were as follow: Diamonsil C18 column and methanol-0.3% diethylamine(75\u223625) as mobile phase,detection wavelength at 280 nm.Result:The recovery range of tetrandrine was 0.191 25-1.53 \u03bcg,r = 0.999 8.The average recovery rate was 97.4% and RSD was 1.3%.Conclusion: The method is simple and accurate,with good repeatability,and can be used for determination of tetrandrine in Xixian Fengshi tablet.",
        "keywords": [
            "HPLC",
            "Xixian Fengshi tablet",
            "Determination",
            "tetrandrine"
        ],
        "authors": [
            {
                "name": "CHEN Jian-feng",
                "org": "Liaoning Chengda Fangyuan Medicine Chained Limited Company,Shenyang ,China"
            },
            {
                "name": "WANG Jing",
                "org": "Liaoning university of Traditional Chinese Medicine,Dalian ,China"
            },
            {
                "name": "YUAN Zi-min",
                "org": "Liaoning university of Traditional Chinese Medicine,Dalian ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2011
    },
    "0fhKL19t": {
        "id": "0fhKL19t",
        "title": "Determination of Linarin in Zhengjujiangya Tablet by RP-HPLC",
        "abstract": "Objective: To establish HPLC for determining the content of linarin in Zhengjujiangya Tablet.Method: A HPLC method was developed.The chromatographic conditions are as follow ZORBAX Eclipse XDB-C18 column and acetonitrile-water(25\u223675) as mobile phase,detection wavelength at 334nm.Result:The linear range of linarin was 0.025\uff5e0.05\u03bcg.The average recovery rate was 98.7% and RSD 2.7%.Conclusion: The method is simple and accurate with good repeatability,and can be used for determinate linarin in Zhengjujiangya Tablet.",
        "keywords": [
            "HPLC",
            "linarin",
            "Zhengjujiangya Tablet"
        ],
        "authors": [
            {
                "name": "CHEN Cui-ying",
                "org": "Liaoning University of TCM,Shenyang ,Liaoning,China"
            },
            {
                "name": "YUAN Zi-min",
                "org": "Liaoning University of TCM,Shenyang ,Liaoning,China"
            },
            {
                "name": "CHENG Lan",
                "org": "Liaoning University of TCM,Shenyang ,Liaoning,China"
            },
            {
                "name": "CHEN Jian-feng",
                "org": "Liaoning Chengda Fangyuan Medicine Chained Limited Company,Shenyang ,Liaoning,China"
            }
        ],
        "venue": "Liaoning Journal of Traditional Chinese Medicine",
        "year": 2007
    },
    "BY28HCCQ": {
        "id": "BY28HCCQ",
        "title": "Determination of Ferullic Acid in Tianmatoutong Tablet by RP-HPLC",
        "abstract": "Objective:To establish RP-HPLC for determining the content of ferullic acid in Tianmatoutong Tablet.Methods:An RPHPLC method was developed.The chromatographic conditions were as follow:Diamonsil C_(18) column and acetonitrile-0.1%glacial acetic acid (20:80) as mobile phase,detection wavelength at 316nm.Results:The recovery range of ferullic acid was 0.00961\uff5e0.07688\u03bcg,r=0.9996.The average recovery rate was 96.9%and RSD was 1.8%.Conclusions:The method is simple and accurate,with good repeatability,and can be used for determination of ferullic acid in Tianmatoutong Tablet.",
        "keywords": [
            "Feraffic acid",
            "Ttianmatoutong Tablet",
            "RP-HPLC"
        ],
        "authors": [
            {
                "name": "Chen Jian-feng",
                "org": " Liaoning Chengda Fangyuan Medicine Chained Limited Company,Shenyang ,China"
            },
            {
                "name": "Yuan Zi-min",
                "org": " Liaoning university of TCM,Dalian ,China"
            },
            {
                "name": "Wang Jing",
                "org": " Liaoning university of TCM,Dalian ,China"
            }
        ],
        "venue": "Chinese Journal of Medicinal Guide",
        "year": 2011
    },
    "NJjWyMAz": {
        "id": "NJjWyMAz",
        "title": "Determination of Dehydrodiisoeugenol in Nutmeg Roasted with Wheat Bran by RP-HPLC",
        "abstract": "Objective:To establish HPLC for determining the content of dehydrodiisoeugenol in Nutmegroasted with wheat bran.Method:An HPLC method was developed.The chromatographic conditions were asfollows:Diamonsil C18 column and methanol-water(75:25) as mobile phase,detection wavelength at 274 nm.Result:The linear range of dehydrodiisoeugenol was 0.075-0.60 \u03bcg(r=0.999 9).The average recovery rate was 98.22% and RSD was 1.9%.Conclusion:The method is simple and accurate with good repeatability,and can be used for determination of dehydrodiisoeugenol in Nutmeg roasted with wheat bran.",
        "keywords": [
            "RP-HPLC",
            "Nutmeg roasted with wheat bran",
            "dehydrodiisoeugenol"
        ],
        "authors": [
            {
                "name": "YUAN Zi-min",
                "org": "School of Pharmacy,Liaoning university of Traditional Chinese Medicine,Dalian ,China"
            },
            {
                "name": "CHEN Jian-feng",
                "org": "Liaoning Chengda Fangyuan Medicine Chained Limited Company,Shenyang ,China"
            },
            {
                "name": "JIA Tian-zhu",
                "org": "School of Pharmacy,Liaoning university of Traditional Chinese Medicine,Dalian ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2011
    },
    "60NFyy5K": {
        "authors": [
            {
                "name": "Xijun Lai",
                "org": "State Key Laboratory of Lake Science and Environment"
            },
            {
                "name": "Jiahu Jiang",
                "org": "State Key Laboratory of Lake Science and Environment"
            },
            {
                "name": "Qun Huang",
                "org": "State Key Laboratory of Lake Science and Environment"
            },
            {
                "name": "Di Wu",
                "org": "State Key Laboratory of Lake Science and Environment"
            }
        ],
        "title": "A level-set based variational method for data assimilation of flood extent into a two-dimensional flood model",
        "abstract": "To fully mine the potential of spatial information from remote sensing data and apply these data to the analysis and prediction of flood routing processes, a variational data assimilation model is proposed based on the level set method. The level set function is introduced to describe the flood front. Combining the variables of water level in the flood model and signed distance in the level set equation, the difficulty of constructing cost function for the assimilation of flood extent is then overcome. The proposed method implement the direct assimilation of the flood extent data into a two-dimensional flood dynamic model. The model was verified by both cases with different scales. One is the laboratory-scale dyke breach; And another one is the real scale of flood diversion to a flood detention area. Results show that: (1) the proposed method can efficiently fuse the hydraulic information hiding in the flood extent data, identify the distributed Manning roughness coefficients and then improve the analysis and prediction of flood routing. (2) Flood extent data include the rich spatial hydraulic information. Their assimilation can help to improve the accuracy of flood simulation.",
        "keywords": [
            "Cost function",
            "Data fusion",
            "Flood prediction",
            "Mathematical model",
            "Variational technique"
        ],
        "venue": "Yingyong Jichu yu Gongcheng Kexue Xuebao/Journal of Basic Science and Engineering",
        "year": 2013,
        "id": "60NFyy5K"
    },
    "hzyWf0mb": {
        "authors": [
            {
                "name": "Yong-Tang Wang",
                "org": "State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University"
            },
            {
                "name": "Xiu-Min Lu",
                "org": "College of Pharmacy and Bioengineering, Chongqing University of Technology"
            },
            {
                "name": "Feng Zhu",
                "org": "College of Pharmacy and Bioengineering, Chongqing University of Technology"
            },
            {
                "name": "Peng Huang",
                "org": "College of Pharmacy and Bioengineering, Chongqing University of Technology"
            },
            {
                "name": "Ying Yu",
                "org": "College of Pharmacy and Bioengineering, Chongqing University of Technology"
            },
            {
                "name": "Zai-Yun Long",
                "org": "State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University"
            },
            {
                "name": "Ya-Min Wu",
                "org": "State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University"
            }
        ],
        "title": "Ameliorative Effects of p75NTR-ED-Fc on Axonal Regeneration and Functional Recovery in Spinal Cord-Injured Rats",
        "abstract": "As a co-receptor of Nogo-66 receptor (NgR) and a critical receptor for paired immunoglobulin-like receptor (PirB), p75 neurotrophin receptor (p75NTR) mediates the inhibitory effects of myelin-associated inhibitors on axonal regeneration after spinal cord injury. Therefore, the p75NTR antagonist, such as recombinant p75NTR protein or its homogenates may block the inhibitory effects of myelin and promote the axonal regeneration and functional recovery. The purposes of this study are to subclone and express the extracellular domain gene of human p75NTR with IgG-Fc (hp75NTR-ED-Fc) in prokaryotic expression system and investigate the effects of the recombinant protein on axonal regeneration and functional recovery in spinal cord-injured rats. The hp75NTR-ED-Fc coding sequence was amplified from pcDNA-hp75NTR-ED-Fc by polymerase chain reaction (PCR) and subcloned into vector pET32a (+), then the effects of the purified recombinant protein on neurite outgrowth of dorsal root ganglion (DRG) neurons cultured with myelin-associated glycoprotein (MAG) were determined, and the effects of the fusion protein on axonal regeneration, functional recovery, and its possible mechanisms in spinal cord-injured rats were further investigated. The results indicated that the purified infusion protein could promote neurite outgrowth of DRG neurons, promote axonal regeneration and functional recovery, and decrease RhoA activation in spinal cord-injured rats. Taken together, the findings revealed that p75NTR still may be a potential and novel target for therapeutic intervention for spinal cord injury and that the hp75NTR-ED-Fc fusion protein treatment enhances functional recovery by limiting tissue loss and stimulating axonal growth in spinal cord-injured rats, which may result from decreasing the activation of RhoA.",
        "keywords": [
            "Axonal regeneration",
            "Functional recovery",
            "Neurite outgrowth",
            "p75NTR-ED-Fc",
            "Spinal cord injury"
        ],
        "venue": "Molecular Neurobiology",
        "year": 2014,
        "id": "hzyWf0mb"
    },
    "VcsQ08Bw": {
        "id": "VcsQ08Bw",
        "title": "Thermal expansion and thermal conductivity of Sm x Zr 1\u2212x O 2\u2212x/2 (0.1\u2264 x \u22640.5) ceramics",
        "abstract": "",
        "keywords": [
            "x ray diffractometer",
            "thermal diffusivity",
            "thermal expansion",
            "thermal expansion coefficient",
            "specific heat",
            "thermal diffusion",
            "thermal barrier coating",
            "transmission electron microscope",
            "room temperature",
            "thermal conductivity"
        ],
        "authors": [
            {
                "name": "zhanguo liu",
                "org": ""
            },
            {
                "name": "jiahu ouyang",
                "org": ""
            },
            {
                "name": "baihe wang",
                "org": ""
            },
            {
                "name": "yu zhou",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            }
        ],
        "venue": "Ceramics International",
        "year": 2009
    },
    "3X1BgV07": {
        "id": "3X1BgV07",
        "title": "Preparation and thermophysical properties of Nd x Zr 1\u2212x O 2\u2212x/2 ( x =0.1, 0.2, 0.3, 0.4, 0.5) ceramics",
        "abstract": "",
        "keywords": [
            "x ray diffractometer",
            "thermal analysis",
            "thermal expansion coefficient",
            "specific heat",
            "thermal diffusivity",
            "thermal conductivity",
            "room temperature",
            "thermal expansion",
            "thermal diffusion",
            "transmission electron microscope",
            "relative density"
        ],
        "authors": [
            {
                "name": "zhanguo liu",
                "org": ""
            },
            {
                "name": "jiahu ouyang",
                "org": ""
            },
            {
                "name": "baihe wang",
                "org": ""
            },
            {
                "name": "yu zhou",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2008
    },
    "kAvhmGwg": {
        "id": "kAvhmGwg",
        "title": "Effect of alumina addition on the phase evolution and thermal conductivity of ZrO 2 \u2013NdO 1.5 ceramics",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "microstructure",
            "specific heat",
            "thermal diffusivity",
            "microstructures",
            "room temperature",
            "thermal conductivity",
            "scanning electron microscopy",
            "raw materials",
            "relative density",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "zhanguo liu",
                "org": ""
            },
            {
                "name": "jiahu ouyang",
                "org": ""
            },
            {
                "name": "yu zhou",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            }
        ],
        "venue": "Journal of Alloys and Compounds",
        "year": 2009
    },
    "nnPcOJbI": {
        "authors": [
            {
                "name": "Li He",
                "org": ""
            },
            {
                "name": "Hui Ding",
                "org": ""
            },
            {
                "name": "Jian-Hua Wang",
                "org": ""
            },
            {
                "name": "Yun Zhou",
                "org": ""
            },
            {
                "name": "Li Li",
                "org": ""
            },
            {
                "name": "Yan-Hong Yu",
                "org": ""
            },
            {
                "name": "Long Huang",
                "org": ""
            },
            {
                "name": "Wei-Hua Jia",
                "org": ""
            },
            {
                "name": "Musheng Zeng",
                "org": ""
            },
            {
                "name": "Jing-Ping Yun",
                "org": ""
            },
            {
                "name": "Rong-Zhen Luo",
                "org": ""
            },
            {
                "name": "Min Zheng",
                "org": ""
            }
        ],
        "title": "Overexpression of Karyopherin 2 in Human Ovarian Malignant Germ Cell Tumor Correlates with Poor Prognosis",
        "abstract": "Background: The aim of this study was to identify a biomarker useful in the diagnosis and therapy of ovarian malignant germ cell tumor (OMGCT). Methods: The karyopherin 2 (KPNA2) expression in OMGCT and normal ovarian tissue was determined by standard gene microarray assays, and further validated by a quantitative RT-PCR and immunohistochemistry. The correlation between KPNA2 expression in OMGCT and certain clinicopathological features were analyzed. Expression of SALL4, a stem cell marker, was also examined in comparison with KPNA2. Results: KPNA2 was found to be over-expressed by approximately eight-fold in yolk sac tumors and immature teratomas compared to normal ovarian tissue by microarray assays. Overexpression was detected in yolk sac tumors, immature teratomas, dysgerminomas, embryonal carcinomas, mature teratomas with malignant transformation and mixed ovarian germ cell tumors at both the transcription and translation levels. A positive correlation between KPNA2 and SALL4 expression at both the transcription level (R = 0.5120, P = 0.0125), and the translation level (R = 0.6636, P<0.0001), was presented. Extensive expression of KPNA2 was positively associated with pathologic type, recurrence and uncontrolled, ascitic fluid presence, suboptimal cytoreductive surgery necessity, resistance/refraction to initial chemotherapy, HCG level and SALL4 level in OMGCT patients. KPNA2 was found to be an independent factor for 5-year disease-free survival (DFS) of OMGCT (P = 0.02). The 5-year overall survival (OS) and DFS rate for KPNA2-low expression patients (88% and 79%, n = 48) were significantly higher than the OS and DFS rate for KPNA2-high expression patients (69% and 57.1%, n = 42)(P = 0.0151, P = 0.0109, respectively). The 5-year OS and DFS rate for SALL4-low expression patients (84% and 74%, n = 62) was marginally significantly higher than the high expression patients (78.6% and 71.4%, n = 28)(P = 0.0519, P = 0.0647, respectively). Conclusions: KPNA2 is a potential candidate molecular marker and important prognostic marker in OMGCT patients. \u00a9 2012 He et al.",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2012,
        "id": "nnPcOJbI"
    },
    "Js9IXPA9": {
        "authors": [
            {
                "name": "Shen-Ping Yu",
                "org": "Department of Radiology"
            },
            {
                "name": "Yan-Ling Zhang",
                "org": "Department of Radiology"
            },
            {
                "name": "Li Jiang",
                "org": "Department of Radiology"
            },
            {
                "name": "Bi-Tao Pan",
                "org": "Department of Radiology"
            },
            {
                "name": "Li He",
                "org": "Department of Radiology"
            },
            {
                "name": "Jian-Yong Yang",
                "org": "Department of Radiology"
            },
            {
                "name": "Quan-Fei Meng",
                "org": "Department of Radiology"
            }
        ],
        "title": "MR perfusion imaging study of the hepatic hemodynamics in pigs",
        "abstract": "Objective: To evaluate the MR perfusion imaging in measuring the hemodynamics of liver. Methods: CT and MR perfusion imaging were performed in livers of 13 pigs. The hepatic artery perfusion (HAP), portal vein perfusion (PVP), total hepatic blood flow (THBF), portal vein perfusion index (PVI), distribution volume (DV) and mean transit time (MTT) were calculated and compared respectively. Hemodynamics of the liver from two kinds of imaging was compared by paired t-test, and the relativity was analyzed by Pearson correlation analysis. Results: In CT and MR perfusion imaging of the 13 pigs: the hepatic artery perfusion (HAP) were (37.71 \u00b1 7.38) and (35.80 \u00b1 7.31) ml \u00b7 min",
        "keywords": [
            "Liver",
            "Magnetic resonance imaging",
            "Tomography, X-ray computed"
        ],
        "venue": "Chinese Journal of Radiology",
        "year": 2008,
        "id": "Js9IXPA9"
    },
    "Y0HAbq5c": {
        "authors": [
            {
                "name": "Zhaoduan Liang",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Siyu Wu",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Yuye Li",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Li He",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Minhao Wu",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Lifang Jiang",
                "org": "Department of Microbiology"
            },
            {
                "name": "Lianqiang Feng",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Ping Zhang",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            },
            {
                "name": "Xi Huang",
                "org": "Key Laboratory of Tropical Diseases Control (Sun Yat-sen University)"
            }
        ],
        "title": "Activation of toll-like receptor 3 impairs the dengue virus serotype 2 replication through induction of IFN-\u03b2 in cultured hepatoma cells",
        "abstract": "Toll-like receptors (TLRs) play an important role in innate immunity against invading pathogens. Although TLR signaling has been indicated to protect cells from infection of several viruses, the role of TLRs in Dengue virus (DENV) replication is still unclear. In the present study, we examined the replication of DENV serotype 2 (DENV2) by challenging hepatoma cells HepG2 with different TLR ligands. Activation of TLR3 showed an antiviral effect, while pretreatment of other TLR ligands (including TLR1/2, TLR2/6, TLR4, TLR5 or TLR7/8) did not show a significant effect. TLR3 ligand poly(I:C) treatment prior to viral infection or simultaneously, but not post-treatment, significantly down-regulated virus replication. Pretreatment with poly(I:C) reduced viral mRNA expression and viral staining positive cells, accompanying an induction of the type I interferon (IFN-\u03b2) and type III IFN (IL-28A/B). Intriguingly, neutralization of IFN-\u03b2 alone successfully restored the poly(I:C)-inhibited replication of DENV2. The poly(I:C)-mediated effects, including IFN induction and DENV2 suppression, were significantly reversed by IKK inhibitor, further suggesting that IFN-\u03b2 is the dominant factor involved in the poly(I:C) mediated antiviral effect. Our study presented the first evidence to show that activation of TLR3 is effective in blocking DENV2 replication via IFN-\u03b2, providing an experimental clue that poly(I:C) may be a promising immunomodulatory agent against DENV infection and might be applicable for clinical prevention. \u00a9 2011 Liang et al.",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2011,
        "id": "Y0HAbq5c"
    },
    "rMSKE2ub": {
        "authors": [
            {
                "name": "Shen-Ping Yu",
                "org": "Department of Radiology"
            },
            {
                "name": "Guo-Liang Chu",
                "org": "Department of Anatomy"
            },
            {
                "name": "Jian-Yong Yang",
                "org": "Department of Radiology"
            },
            {
                "name": "Li He",
                "org": "Department of Radiology"
            },
            {
                "name": "Hua-Qiao Wang",
                "org": "Department of Anatomy"
            }
        ],
        "title": "Direct intrahepatic portocaval shunt through transhepatic puncture via retrohepatic inferior vena cava: Applied anatomical study",
        "abstract": "Background: DIPS is to create a portosystemic shunt directly between the portal vein and the retrohepatic inferior vena cava (RIVC) without passing through the hepatic vein. It has been recommended that the DIPS could be applied when routine TIPS is unsuccessful or the patient has anatomical variations of the hepatic vein. The aim of this study was to identify the safe area of the RIVC where the DIPS can be safely established. Materials and methods: The lengths of the safe and unsafe areas of the RIVC were measured. The tributaries of the RIVC were examined. The diameter of these tributaries was measured and their incidence and relation to the safe area of the RIVC were observed. The puncture distances of DIPS and TIPS were measured and compared. Results: The liver together with the RIVC was collected from 31 adult cadavers (age 32-65 years; M/F 25/6). 1. The safe and unsafe areas of the RIVC: the total length of the RIVC was 70.1 \u00b1 13.0 mm (33.1-92.0 mm), whereas the length of the safe area of the RIVC was 54.3 \u00b1 12.3 mm (20.2-71.1 mm), which was about over 70% of the total length. The length of the unsafe area at the upper end was 5.9 \u00b1 1.8 mm (3.0-10.2 mm), and at the lower end was 8.9 \u00b1 2.9 mm (3.1-20.0 mm). 2. The tributaries of the RIVC: In about 90% of the cadavers (90.3%; 28 out of 31), the LHV and MHV had the common trunk. The other three cadavers (9.7%; 3 out of 31) had independent RHV, MHV and LHV. There were 217 of small hepatic veins draining into the lower segment of the RIVC. Over 70% of the small hepatic veins were smaller than 5 mm in diameter and distributed on the anterior and left wall of the lower RIVC. 3. Puncture distances of the DIPS and TIPS: The distances from the bifurcation of the portal vein to the RIVC, to the right and to middle hepatic veins were 31.2 \u00b1 7.9 mm (15.0-47.2 mm), 38.6 \u00b1 8.1 mm (17.2-59.0 mm), and 46.6 \u00b1 8.2 mm (34.0-68.1 mm), respectively. Thus, the puncture distances via the RIVC, RHV and LHV were significantly different (P < 0.001). The puncture distance of the DIPS was shortest. Conclusion: Anatomically, DIPS is a feasible interventional procedure to make a intrahepatic shunt between IVC and portal vein directly, and has its anatomical advantages compared to TIPS. \u00a9 Springer-Verlag 2008.",
        "keywords": [
            "Anatomy",
            "DIPS",
            "Direct intrahepatic portocaval shunt",
            "Inferior vena cava",
            "Interventional radiology",
            "Liver",
            "Transhepatic puncture"
        ],
        "venue": "Surgical and Radiologic Anatomy",
        "year": 2009,
        "id": "rMSKE2ub"
    },
    "JuVUl4Pp": {
        "authors": [
            {
                "name": "Shen-Ping Yu",
                "org": ""
            },
            {
                "name": "Li He",
                "org": ""
            },
            {
                "name": "Bo Liu",
                "org": ""
            },
            {
                "name": "Xiao-Zhao Zhuang",
                "org": ""
            },
            {
                "name": "Ming-Juan Liu",
                "org": ""
            },
            {
                "name": "Xiao-Shu Hu",
                "org": ""
            }
        ],
        "title": "Differential diagnosis of metastasis from non-metastatic lymph nodes in cervical cancers: Pilot study of diffusion weighted imaging with background suppression at 3t magnetic resonance",
        "abstract": "Background Diffusion weighted imaging with background suppression (DWIBS) is potentially useful in detecting metastatic lymph nodes. This study aimed to evaluate the efficacy of DWIBS at 3T magnetic resonance (MR) for diagnosing metastatic lymph nodes in cervical cancer. Methods This retrospective study included 25 patients with cervical cancer who underwent MR examination and were treated by hysterectomy and lymphadenectomy. The metastatic and non-metastatic lymph nodes were histologically proven by operation. Apparent diffusion coefficient (ADC) values, long-axis diameters, short-axis diameters, ratio of short- to long-axis diameters of all the identifiable lymph nodes were measured and compared. Results Twenty-five primary tumor lesions, 17 metastatic lymph nodes and 140 non-metastatic lymph nodes were pathologically confirmed in 25 cases with cervical cancer. The difference of ADC values between primary tumor lesions, metastatic and non-metastatic lymph nodes were statistically significant (F=7.93, P=0.001). There was no statistically significant difference between primary tumor lesions of cervical cancer and metastatic lymph nodes (t=-0.75, P=0.456), and the difference between primary tumor lesions and non-metastatic lymph nodes was statistically significant (t =4.68, P <0.001). The ADC values, long-axis diameters, short-axis diameters, ratio of short- to long-axis diameters of metastatic and non-metastatic lymph nodes were (0.86\u00b10.36)\u00d710 ",
        "keywords": [
            "Apparent diffusion coefficient",
            "Cervical cancer",
            "Diffusion weighted imaging",
            "Metastatic lymph node"
        ],
        "venue": "Chinese Medical Journal",
        "year": 2010,
        "id": "JuVUl4Pp"
    },
    "QUSkLZ05": {
        "authors": [
            {
                "name": "Min Zheng",
                "org": "Department of Gynecology"
            },
            {
                "name": "Long Huang",
                "org": "Department of Gynecology"
            },
            {
                "name": "Li He",
                "org": "Department of Gynecology"
            },
            {
                "name": "Hui Ding",
                "org": "Department of Gynecology"
            },
            {
                "name": "Hui-Yun Wang",
                "org": "State Key Laboratory of Oncology in Southern China"
            },
            {
                "name": "Li.-Min Zheng",
                "org": "State Key Laboratory of Oncology in Southern China"
            }
        ],
        "title": "Evaluation of the effects of type II radical hysterectomy in the treatment of 960 patients with stage IB-IIB cervical carcinoma: A retrospective study",
        "abstract": "Background and Objectives: This retrospective study evaluated the feasibility and effectiveness of type II radical hysterectomies alone, or in combination with adjuvant treatment, for the treatment of patients with stage IB-IIB cervical cancer with or without high-risk factors. Methods: A total of 960 stage IB-IIB patients who underwent type II radical hysterectomies between 1995 and 2004 were enrolled and retrospectively analyzed. Results: Uterine corpus invasion, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors for stage IB patients. For stage IIA-IIB patients, histologic type, parametrial margin involvement, and pelvic lymph node metastasis were identified as independent prognostic factors. The 5-year overall survival (OS) rates for patients with stage IB versus stage IIA-IIB cervical carcinomas were 88.4% and 78.5%, respectively. Moreover, adjuvant radiotherapy and chemotherapy improved the 5-yearOSrates of stage IIA-IIB patients associated with high-risk factors. The overall recurrence rate for this cohort was 14.4%. Conclusions: Our findings show that type II radical hysterectomy is a feasible treatment option for stage IB-IIB cervical carcinoma patients. Furthermore, type II radical hysterectomy combined with adjuvant post-operative therapy improves the OS of women with high-risk factors for cervical carcinoma. \u00a9 2010 Wiley-Liss, Inc.",
        "keywords": [
            "Adjuvant therapy",
            "Cervical cancer",
            "Prognostic factors",
            "Radical hysterectomy"
        ],
        "venue": "Journal of Surgical Oncology",
        "year": 2011,
        "id": "QUSkLZ05"
    },
    "nZaLG0kE": {
        "authors": [
            {
                "name": "Ling-Min Liao",
                "org": "Guangdong Key Laboratory of Medical Molecular Imaging"
            },
            {
                "name": "Min Zheng",
                "org": "Department of Gynecology"
            },
            {
                "name": "Long Huang",
                "org": "Department of Gynecology"
            },
            {
                "name": "Hui Ding",
                "org": "Department of Gynecology"
            },
            {
                "name": "Li He",
                "org": "Department of Gynecology"
            },
            {
                "name": "Ying Zhang",
                "org": "Department of Sample Bank"
            },
            {
                "name": "Hui-Yun Wang",
                "org": "State Key Laboratory of Oncology in Southern China"
            }
        ],
        "title": "Molecular characterization of early adenocarcinoma of the uterine cervix by oligonucleotide microarray",
        "abstract": "Purpose: In an attempt to understand the molecular characterization for the early adenocarcinoma of the uterine cervix, an analysis of gene expression profiles obtained from early adenocarcinoma of the uterine cervix was performed to find those genes most aberrantly expressed. Methods and materials: Total RNA was prepared from 32 samples of early adenocarcinoma of the uterine cervix and 32 paired normal cervix tissues, and hybridized to cancer-associated oligonucleotide microarrays with probe sets complementary to about 1,426 transcripts. Results: Supervised analysis of gene expression data identified 13 genes that exhibited >2-fold upregulation and 27 genes >2-fold downregulation, respectively, in early adenocarcinoma of the uterine cervix compared to normal cervix. Unsupervised hierarchical clustering of the expression data readily distinguished early adenocarcinoma of the uterine cervix from normal cervix. Two genes (karyopherin alpha 2 and proliferating cell nuclear antigen) were selected randomly for real-time reverse transcription polymerase chain reaction analysis. Both genes were expressed significantly higher in early adenocarcinoma of the uterine cervix than in normal cervix, with p = 0.0003 and <0.0001, respectively. These results were compatible with the microarray data. Conclusions: This study has revealed several genes that may be highly attractive candidate molecular markers/targets for early adenocarcinoma of the uterine cervix. \u00a9 Springer-Verlag 2010.",
        "keywords": [
            "Adenocarcinoma",
            "Gene expression",
            "Oligonucleotide microarray",
            "Uterine cervix"
        ],
        "venue": "Archives of Gynecology and Obstetrics",
        "year": 2011,
        "id": "nZaLG0kE"
    },
    "tb0ciBtw": {
        "authors": [
            {
                "name": "Li He",
                "org": "TCM Hospital"
            },
            {
                "name": "Xiuling Gao",
                "org": "TCM Hospital"
            },
            {
                "name": "Li Yu",
                "org": "TCM Hospital"
            }
        ],
        "title": "Forty cases of simple obesity treated by acupuncture",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Journal of Traditional Chinese Medicine",
        "year": 2006,
        "id": "tb0ciBtw"
    },
    "xtjo1Nzc": {
        "authors": [
            {
                "name": "Xiao-Zhao Zhuang",
                "org": "Department of Radiology"
            },
            {
                "name": "Shen-Ping Yu",
                "org": "Department of Radiology"
            },
            {
                "name": "Li He",
                "org": "PET Center"
            },
            {
                "name": "Ji Cui",
                "org": "Department of Radiology"
            },
            {
                "name": "Chuang-Qi Chen",
                "org": "Department of Radiology"
            },
            {
                "name": "Xiao-Juan Zhao",
                "org": "Department of Radiology"
            },
            {
                "name": "Bi-Tao Pan",
                "org": "Department of Radiology"
            },
            {
                "name": "Zi-Ping Li",
                "org": "Department of Radiology"
            }
        ],
        "title": "3.0T MR DWIBS in diagnosis of lymph nodes metastasis of malignant pelvic tumors",
        "abstract": "Objective: To evaluate the efficacy of diffusion-weighted imaging with background signal suppression (DWIBS) using 3.0T MR scanner for diagnosing lymph nodes metastasis in patients with pelvic malignant tumors. Methods: Totally 60 patients with pelvic malignant tumor underwent preoperative routine MRI+DWI examination and tumor dissection+pelvic lymph node dissection within 2 weeks. Metastatic and non-metastatic lymph nodes were confirmed by pathology after operation. ADC values, long-axis and short-axis diameters of lymph nodes were measured and statistical analyzed. Diagnostic efficacy of ADC values, long-axis and short-axis diameters in differentiating metastatic lymph nodes from non-metastatic lymph nodes by comparing area under curve (AUC) of ROC were assessed. Results: Eighty-two metastatic lymph nodes and 224 non-metastatic lymph nodes were identified. There was statistical difference in short-axis diameter (P=0.001) and short-long axis diameter ratio (P=0.008), but no statistical difference was found in long-axis diameter (P=0.480) between metastatic lymph nodes and non-metastatic lymph nodes. The ADC values of metastatic lymph nodes and non-metastatic lymph nodes were (0.86\u00b10.20) \u00d7 10",
        "keywords": [
            "Apparent diffusion coefficient",
            "Diffusion magnetic resonance imaging",
            "Lymph nodes",
            "Pelvic neoplasms"
        ],
        "venue": "Chinese Journal of Medical Imaging Technology",
        "year": 2012,
        "id": "xtjo1Nzc"
    },
    "ONO3Ncc1": {
        "authors": [
            {
                "name": "Shenping Yu",
                "org": "Department of Radiology"
            },
            {
                "name": "Li He",
                "org": "Department of Radiology"
            },
            {
                "name": "Xiaozhao Zhuang",
                "org": "Department of Radiology"
            },
            {
                "name": "Boning Luo",
                "org": "Department of Radiology"
            }
        ],
        "title": "Pleomorphic xanthoastrocytoma: MR imaging findings in 19 patients",
        "abstract": "Background: Pleomorphic xanthoastrocytoma (PXA) is a rare and special type of astrocytoma which occurs in childhood and adolescence, and usually with a favorable prognosis. Since its initial description, PXA cases have been reported infrequently in the literature, mostly as single cases or small series. Purpose: To review the imaging characteristics of PXA. Material and Methods: MR imaging findings of 19 pathologically confirmed PXAs were retrospectively analyzed and correlated with the clinical and pathological features. Results: The clinical presentation in 18 patients included: dizziness (8); headache (9); and epilepsy (8). One patient was asymptomatic. On MR imaging, the tumors were located in the brain surface (17), thalamus (1) or deep in the right frontal lobe (1). The tumors were cystic (4), mixed cystic-solid (7), or solid (8) with welldefined (11) or poorly-defined borders (8). Peritumoral edema was marked (8), mild (9) or absent (2). Cystic components of tumors were hypointense on T1- and hyperintense on T2-weighted images whereas the solid components of tumors were hypointense or isointense on T1- and slightly hyperintense on T2-weighted images. There was marked (10), moderate (7) or no (2) contrast enhancement in the solid tumors with surrounding leptomeningeal enhancement (7). The tumors were located in the frontal lobes (8), temporal lobes (7), occipital lobe (1), cerebellum (1), thalamus (1), and sellar region (1). Histologically, 18 tumors were classified as WHO grade 2 comprising of pleomorphic giant cells, spindle cells and foamy cells. One PXA with anaplastic features was composed of pleomorphic polygonal cells and spindle cells, and with high mitotic activity (\u22655 mitoses per 10 HPF). Immunohistochemical reactions to glial fibrillary acidic protein (GFAP) were positive in all 19 cases. Conclusion: The pathological appearances of PXA are distinctive. MR imaging could display the morphologic features exactly, and has important diagnostic value for PXA.",
        "keywords": [
            "Diagnosis",
            "Magnetic resonance imaging (MRI)",
            "Pleomorphic xanthoastrocytoma (PXA)"
        ],
        "venue": "Acta Radiologica",
        "year": 2011,
        "id": "ONO3Ncc1"
    },
    "ufNoggQ6": {
        "authors": [
            {
                "name": "Min Zheng",
                "org": "Department of Gynecology"
            },
            {
                "name": "Long Huang",
                "org": "Department of Gynecology"
            },
            {
                "name": "Ji-Hong Liu",
                "org": "Department of Gynecology"
            },
            {
                "name": "Ying Xiong",
                "org": "Department of Gynecology"
            },
            {
                "name": "Jun-Dong Li",
                "org": "Department of Gynecology"
            },
            {
                "name": "Xin Huang",
                "org": "Department of Gynecology"
            },
            {
                "name": "Li He",
                "org": "Department of Gynecology"
            },
            {
                "name": "Yu-Feng Ren",
                "org": "State Key Laboratory of Oncology in Southern China"
            },
            {
                "name": "Hui-Yun Wang",
                "org": "State Key Laboratory of Oncology in Southern China"
            }
        ],
        "title": "Type II radical hysterectomy and adjuvant therapy for pelvic lymph node metastasis with stage IB-IIB cervical carcinoma: A retrospective study of 288 patients",
        "abstract": "Background and Objectives: The aim of this study was to evaluate type II radical hysterectomy with or without adjuvant therapy as a treatment for patients with pelvic lymph node metastasis (PLNM) and stage IB-IIB cervical carcinoma. Methods: A total of 288 patients with stage IB-IIB cervical carcinoma and confirmed PLNM who underwent a type II radical hysterectomy between 1995 and 2005 were retrospectively evaluated. Results The 5-year overall survival (OS) rate for this cohort was 65.6%, and independent prognostic factors identified for PLNM patients included a non-squamous cell histological subtype and parametrial involvement. Survival differences between patients that received or did not receive adjuvant treatment were also evaluated, and the 5-year OS and DFS rates for patients who did not receive adjuvant therapy (47 and 41.4%, respectively) were much lower than the rates for patients who did receive adjuvant therapies (67.7 and 59.4%, respectively). However, these differences were not statistically significant (OS, P = 0.057; DFS, P = 0.080). Conclusions: Type II radical hysterectomy, in combination with adjuvant therapies, is an efficient treatment for PLNM patients with stage IB-IIB cervical cancer. \u00a9 2011 Wiley-Liss, Inc.",
        "keywords": [
            "cervical carcinoma",
            "PLNM",
            "prognostic factors",
            "type II radical hysterectomy"
        ],
        "venue": "Journal of Surgical Oncology",
        "year": 2011,
        "id": "ufNoggQ6"
    },
    "Bm0YXpON": {
        "id": "Bm0YXpON",
        "title": "The Relation of Serum CA125 and Outcome of the First-trimester Threatened Abortion",
        "abstract": "Objective To determine the value of serum CA125 in prediction of the first-trimester threatened abortion.Methods To measure serum CA125 of 51 threatened abortion and 30 normal pregnancy of the first-trimester with chemiluminescent immunoassay(CLIA) methods.Results There was a significant increase in serum CA125 in women who aborted compared with the control group and non-aborted women(P<0.01).Conclusion Single serum CA125 is valuable in predicting pregnancy outcome of first-trimester threatened abortion.",
        "keywords": [
            "threatened abortion",
            "serum CA125",
            "pregnancy outcome"
        ],
        "authors": [
            {
                "name": "DU Ji-hong",
                "org": "The Second People's Hospital of Foshan City,Foshan,Guangdong ,China"
            },
            {
                "name": "ZHENG Xun-feng",
                "org": "The Second People's Hospital of Foshan City,Foshan,Guangdong ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "The Second People's Hospital of Foshan City,Foshan,Guangdong ,China"
            }
        ],
        "venue": "Journal of Nanhua University(Medical Edition)",
        "year": 2006
    },
    "WoLQs7Y6": {
        "id": "WoLQs7Y6",
        "title": "Microinvasive Uterine Manipulator for Laparoscopic Nerve-sparing Radical Hysterectomy",
        "abstract": "Objective To investigate the clinical value of the microinvasive uterine manipulator in laparoscopic nerve-sparing radical hysterectomy(LNSRH). Methods From January 2009 to April 2011,20 patients with cervical cancer(stage \u2160B-\u2161A) and 10 patients with endometrial carcinoma(stage\u2161),underwent LNSRH by using microinvasive uterine manipulator.After inserting Foley catheter,we placed the uterine manipulator to remove the vagina after a laparoscopic resection. Results LNSRH was finished successfully in all the cases without urinary injury.The operation time ranged form 250 to 340 min with a mean of 270 min,during which 50-200 ml blood loss was measured(mean,110 ml).After the operation,the Foley catheter was withdrawn on day 7 to day 17(mean,10 d).The patients were followed up for 3 to 30 months(mean,16.7 months).All the patients survived without lymphatic cyst,recurrent tumor,or metastasis;the vaginal stump were healed well in all the cases. Conclusion Microinvasive uterine manipulator is economic and easy to operate,and thus is an ideal choice for LNSRH.",
        "keywords": [
            "Preservation of the pelvic autonomic nerve",
            "Laparoscopy",
            "Cervical cancer",
            "Endometrial carcinoma",
            "Radical hysterectomy",
            "Uterine manipulator"
        ],
        "authors": [
            {
                "name": "Wang Shuai",
                "org": ".Department of Gynecology,South China Sea People's Hospital,Southern Medical University,Foshan ,China"
            },
            {
                "name": "Huang Hao",
                "org": ".Department of Gynecology,South China Sea People's Hospital,Southern Medical University,Foshan ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2012
    },
    "g7B5i03N": {
        "id": "g7B5i03N",
        "title": "Role of PK System in Laparoscopic Operation for Early-Stage Malignant Uterine Tumors",
        "abstract": "Objective To evaluate the clinical value of PK system in laparoscopic radical hysterectomy and pelvic lymphadenectomy for malignant uterine tumors. Methods From January 2003 to December 2006, laparoscopic radical hysterectomy and pelvic lymphadenectomy with PK system were performed on 30 patients with biopsy-confirmed early-stage malignant uterine tumors including 19 cases of cervical cancer and 11 cases of endometrial cancer. Results All the operations were completed without conversion to open surgery. The mean operation time was (253.2\u00b155.3) min,and mean blood loss was (310.0\u00b1147.7) ml. The mean operation time for pelvic lymph nodes removal was (73.5\u00b123.6) min, and a mean of (17.0\u00b16.2) pelvic lymph nodes were removed. The postoperative gastrointestinal function of the patients recovered within (32.3\u00b111.2) h after the operation, and antibiotics were used for (5.5\u00b11.5) d. The mean postoperative hospital stay was (12\u00b15) d. One patient had bladder injury during the operation, 3 had a fever (\u226538.5 \u2103) after the operation, 4 developed urinary retention, and 1 had lymphadenocyst. Conclusions PK System is a good device for reducing blood loss and operative injury during laparoscopic operation. It is safe, feasible, effective and reliable for radical hysterectomy and pelvic lymphadenectomy for malignant uterine tumors.",
        "keywords": [
            "Lymphadenectomy",
            "Hysterectomy",
            "Laparoscopic operation",
            "Cervical cancer",
            "Endometrial cancer",
            "PK system"
        ],
        "authors": [
            {
                "name": "Huang Yi",
                "org": ", et al.Department of Obstetrics and Gynecology, Foshan Second People\u2019s Hospital, Foshan , China."
            },
            {
                "name": "Huang Hao",
                "org": ", et al.Department of Obstetrics and Gynecology, Foshan Second People\u2019s Hospital, Foshan , China."
            },
            {
                "name": "Qiu Guixiang",
                "org": ", et al.Department of Obstetrics and Gynecology, Foshan Second People\u2019s Hospital, Foshan , China."
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2008
    },
    "zVfVx7cu": {
        "id": "zVfVx7cu",
        "title": "The impact of hydrosalpinx on reproductive outcome post treatment of hysteroscopy combined with laparoscopy surgery in infertility patients",
        "abstract": "Objective To investigate the improvement of reproductive function after hysteroscopy integrated with laparoscopy operation for treating infertility in tubal infertility patients with hydrosalpinx.Methods The clinical data of 82 cases of tubal infertility patients accepted hysteroscopy combined with laparoscopy operation during July 2008 to June 2010 were recruited,and 79 cases were enrolled in present study at last after excluding 3 cases who were suggested to do in vitro fertilization and embryo transfer(IVF-ET) because of the bilateral proximal tubal obstruction.According to presence or absence of hydrosalpinx,79 enrollment cases were divided into two groups: hydrosalpinx group(n=42) and non-hydrosalpinx group(n=37).The followed-up period was two years,and the pregnancy outcomes in two groups were compared.Results The total intrauterine gestation rate was 41.8%,while the intrauterine gestation rate in hydrosalpinx group was significantly lower than that in non-hydrosalpinx group [31.0%(13/42) vs 54.1%(20/37),P<0.05].There were 5 cases of ectopic pregnancy and 3 cases of abortion in hydrosalpinx group,while only 1 case of ectopic pregnancy and 1 case of abortion in non-hydrosalpinx group,but there was no significant difference in two groups(P>0.05).The gestation rate decreases with aggravating of hydrosalpinx degree.Conclusions Hydrosalpinx could influence fertility outcome after treatment of hysteroscopy combined with laparoscopy surgery in infertility patients.The pregnancy rate significantly lowers in infertility patients with \u2162-\u2163 stage of hydrosalpinx,and the hysteroscopy combined with laparoscopy operation has poor treatment effect to these patients.",
        "keywords": [
            "Hysteroscopy",
            "Infertility",
            "Fertility",
            "Hydrosalpinx",
            "Laparoscopy"
        ],
        "authors": [
            {
                "name": "WEN Zhong-yong",
                "org": ""
            },
            {
                "name": "HUANG Shi-min",
                "org": ""
            },
            {
                "name": "HUANG Hao",
                "org": ""
            },
            {
                "name": "HU Bi-hong",
                "org": ""
            },
            {
                "name": "Wang Feng",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Clinical Research",
        "year": 2013
    },
    "aWSOj49g": {
        "id": "aWSOj49g",
        "title": "Nek9 regulates spindle organization and cell cycle progression during mouse oocyte meiosis and its location in early embryo mitosis.",
        "abstract": "Nek9 (also known as Nercc1), a member of the NIMA (never in mitosis A) family of protein kinases, regulates spindle formation, chromosome alignment and segregation in mitosis. Here, we showed that Nek9 protein was expressed from germinal vesicle (GV) to metaphase II (MII) stages in mouse oocytes with no detectable changes. Confocal microscopy identified that Nek9 was localized to the spindle poles at the metaphase stages and associated with the midbody at anaphase or telophase stage in both meiotic oocytes and the first mitotic embyros. Depletion of Nek9 by specific morpholino injection resulted in severely defective spindles and misaligned chromosomes with significant pro-MI/MI arrest and failure of first polar body (PB1) extrusion. Knockdown of Nek9 also impaired the spindle-pole localization of \u03b3-tubulin and resulted in retention of the spindle assembly checkpoint protein Bub3 at the kinetochores even after 10 h of culture. Live-cell imaging analysis also confirmed that knockdown of Nek9 resulted in oocyte arrest at the pro-MI/MI stage with abnormal spindles, misaligned chromosomes and failed polar body emission. Taken together, our results suggest that Nek9 may act as a MTOC-associated protein regulating microtubule nucleation, spindle organization and, thus, cell cycle progression during mouse oocyte meiotic maturation, fertilization and early embryo cleavage.",
        "keywords": [
            "morpholinos",
            "spindle apparatus",
            "meiosis",
            "kinetochores",
            "mitosis",
            "oocyte",
            "tubulin",
            "chromosomes"
        ],
        "authors": [
            {
                "name": "Yang Shang-Wu",
                "org": "State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China."
            },
            {
                "name": "Gao Chen",
                "org": ""
            },
            {
                "name": "Chen Lei",
                "org": ""
            },
            {
                "name": "Song Ya-Li",
                "org": ""
            },
            {
                "name": "Zhu Jin-Liang",
                "org": ""
            },
            {
                "name": "Qi Shu-Tao",
                "org": ""
            },
            {
                "name": "Jiang Zong-Zhe",
                "org": ""
            },
            {
                "name": "Wang Zhong-Wei",
                "org": ""
            },
            {
                "name": "Lin Fei",
                "org": ""
            },
            {
                "name": "Huang Hao",
                "org": ""
            },
            {
                "name": "Xing Fu-Qi",
                "org": ""
            },
            {
                "name": "Sun Qing-Yuan",
                "org": ""
            }
        ],
        "venue": "Cell cycle (Georgetown, Tex.)",
        "year": 2012
    },
    "JF5sLQbA": {
        "id": "JF5sLQbA",
        "title": "Clinical Analysis of the Different Surgical Methods for Treatment of Tubal Pregnancy on Ovarian Function and Reproductive Outcome",
        "abstract": "Objective:Study of immediate impact on ovarian function and fertility outcomes after different surgical methods for treatment of tubal pregnancy.Methods:Infertility treatment in patients with tubal pregnancy in 121 cases.All patients underwent laparoscopic surgery,tubal resection in 37 cases,41 cases of fallopian tubes cut to take the embryo surgery,partial salpingectomy in 43 cases,comparison of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2)preoperative,postoperative 1 month,3 months after surgery,patients were followed up for 2 years to understand their ovulation and pregnancy.Results:FSH and LH were significantly higher in patients with salpingectomy after 1 month and 3 month,compared with the preoperative,E2 decreased.Difference was statistically significant(P<0.05);after six months ovulation rate was 82.45%,the postoperative pregnancy rate was 39.62%;the remaining two groups of patients after one month,three months hormone levels compared with the preoperative were no significant differences(P>0.05);months after operation ovulation rates were 91.32%,89.51%,the postoperative pregnancy rate was 43.62%,45.71%;compared with patients with salpingectomy,ovulation rate and postoperative intrauterine pregnancy rates were slightly higher,but the difference was not statistically significance(P>0.05).Conclusion:Tubal lesions is a key factor in determining the surgical approach to preserve the fallopian tube can retain the ovarian part of the blood supply,to avoid affecting the ovulation rate and pregnancy rate after surgery.",
        "keywords": [
            "Ovarian function",
            "Fertility",
            "Surgery",
            "Tubal pregnancy"
        ],
        "authors": [
            {
                "name": "HUANG Shimin",
                "org": ".Department of Gynecology and Obstetrics,the People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            },
            {
                "name": "HUANG Hao",
                "org": ".Department of Gynecology and Obstetrics,the People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            }
        ],
        "venue": "The Journal of Medical Theory and Practice",
        "year": 2012
    },
    "7nJWjOtD": {
        "id": "7nJWjOtD",
        "title": "Comprehensive Laparoscopic Staging on Early-stage Ovarian Carcinoma",
        "abstract": "Objective To investigate the safety and feasibility of comprehensive laparoscopic staging on early-stage ovarian carcinoma.Methods From June 2008 to October 2010,5 patients with early stage ovarian carcinoma underwent comprehensive laparoscopic staging in our hospital.The clinical pathology and follow-up data of the patients were analyzed retrospectively.The key surgical steps included a comprehensive exploration of the pelvic abdominal cavity,frozen section,and then comprehensive staging surgery of the ovarian cancer(pelvic lymph node dissection,and then cutting off the funnel ligament,condensating the uterine vessels,bilateral sacral ligament,and cardinal ligament with the harmonic scalpel,and pushing down the rectum,and finally removal of the vagina).We did the omental resection,removed the appendix,put the vaginal sleeve circumcision into the vagina,and finally removed the attachments,pelvic lymph nodes,omentum appendix and uterus from the vagina.After the procedure,the vaginal stump and pelvic peritoneum was sutured without leaving a drainage tube.Results All the procedures were completed successfully without conversion to laparotomy,no major intraoperative or postoperative complications occurred.The mean operation time was(230.1\u00b136.0) min,and intraoperative blood loss was(103.2\u00b113.5) ml.A mean of 15.8\u00b15.6 pelvic lymph nodes were removed during the procedure.The patients' gastrointestinal function recovered in(2.3\u00b10.4) days after the surgery,and the urine catheter was removed in 48 hours.The mean postoperative hospital stay of the patients was(14.7\u00b14.0) days.Postoperative pathological examination showed two cases of ovarian serous papillary adenocarcinoma,two cases of ovarian mucinous adenocarcinoma and one case of ovarian clear cell adenocarcinoma;and pathological staging showed four cases of stage \u2160 and 1 cases of stage \u2161.The paitent were followed up for 8-24 months with a mean of(18.4\u00b15.6) months,during which no recurrence or metastasis to the puncture site was observed.Conclusion Comprehensive laparoscopic staging is safe and feasible for early-stage ovarian carcinoma with good short-term outcomes and quick postoperative recovery.",
        "keywords": [
            "Laparoscopy",
            "Comprehensive laparoscopic staging",
            "Ovarian carcinoma"
        ],
        "authors": [
            {
                "name": "Wang Xiaojie",
                "org": ".Department of Gynecology and Obstetrics,Hospital of Nanhai District,Foshan ,China"
            },
            {
                "name": "Yang Shangwu",
                "org": ".Department of Gynecology and Obstetrics,Hospital of Nanhai District,Foshan ,China"
            },
            {
                "name": "Huang Hao",
                "org": ".Department of Gynecology and Obstetrics,Hospital of Nanhai District,Foshan ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2012
    },
    "GNHAChWp": {
        "id": "GNHAChWp",
        "title": "Application of Marvelon after Resection of Endometrial Polyps",
        "abstract": "Objective To investigate the application of marvelon tablet after hysteroscopic polypectomy,and to discuss the value of the combined application of marvelon and hysteroscopic polypectomy in the treatment and prevention of recurrence of endometrial polyps.Methods Eighty patients with benign endometrial polyps(EP) underwent hysteroscopic polypectomy.Among these patients,40 patients took marvelon tablet for 3 months(observation group) and other 40 patients without medication were selected as control group.Patients were followed up for 3 months to observe the recurrence of EP,bleeding status,endometrial thickness and the second hysteroscopy,and the results were compared between the two groups.Results Patients in observation group resumed normal menses.Compared with control group,mid-menstrual endometrial thickness significantly decreased in observation group[(6.72\u00b11.66)mm vs(9.28\u00b11.23)mm,P<0.05].The incidence of EP recurrence was 2.5% and 15.0% in observation group and control group,respectively,with a significant difference between the two groups(P<0.05).ConclusionCombined application of marvelon and hysteroscopic polypectomy can effectively improve menstrual disorder,and decrease endometrial thickness and EP recurrence.",
        "keywords": [
            "recurrence",
            "hysteroscopy",
            "marvelone",
            "endometrial polyps"
        ],
        "authors": [
            {
                "name": "HU Bi-hong",
                "org": "Department of Obstetrics and Gynecology,Nanhai Hospital of Southern Medical University,Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Department of Obstetrics and Gynecology,Nanhai Hospital of Southern Medical University,Foshan ,China"
            }
        ],
        "venue": "Journal of Nanchang University(Medical Science)",
        "year": 2011
    },
    "XwyDDhnP": {
        "id": "XwyDDhnP",
        "title": "Laparoscopic versus open radical hysterectomy for endometrial cancer: A prospective,randomized,controlled study",
        "abstract": "Objective To investigate the clinical effect of laparoscopic radical hysterectomy in the treatment of early-stage endometrial cancer.Methods A total of 60 consecutive patients preoperatively diagnosed as having stage \u2160 or \u2161 endometrial cancer from August 1998 to December 2004 was divided into two groups,receiving either laparoscopic(Laparoscopic Group) or open radical hysterectomy(Open Group).According to the involvement of the muscular layer,whether or not a pelvic lymphadenectomy was required was determined.Perioperative parameters and survival time were prospectively studied.Results As compared with the Open Group,the Laparoscopic Group presented a longer operation time(247.8\u00b177.8 min vs 196.6\u00b163.7 min;t=2.789,P=0.007),similar blood loss(265.0\u00b1187.6 ml vs 350.0\u00b1210.9 ml;t=-1.649,P=0.104),similar number of resected lymph nodes(22.0\u00b15.0 vs 22.8\u00b15.2;t=-0.607,P=0.546),insignificant difference in complication rate (10/30 vs 15/30;\u03c72=1.714,P=0.190),earlier time to first passing flatus(44.3\u00b111.1 min vs 55.2\u00b112.8 min;t=-3.524,P=0.000),and shorter hospital stay(8.7\u00b13.2 d vs 10.2\u00b12.0 d;t=-2.177,P=0.034).The patients in the Laparoscopic Group were followed for 28.6\u00b117.4 months with tumor-free survival.In the Open Group,a follow-up for 28.9\u00b116.6 months found 3 deaths form metastasis or recurrence.Conclusions Laparoscopic radical hysterectomy and pelvic lymphadenectomy may be an alternative for early-stage endometrial carcinoma.",
        "keywords": [
            "Surgical treatment",
            "Laparoscopy",
            "Endometrial carcinoma"
        ],
        "authors": [
            {
                "name": "Chen Xiaohong",
                "org": "*.*Department of Obstetrics & Gynecology,Foshang Second People's Hospital,Foshan ,China"
            },
            {
                "name": "Huang Hao",
                "org": "*.*Department of Obstetrics & Gynecology,Foshang Second People's Hospital,Foshan ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2007
    },
    "jshaQ1Ok": {
        "id": "jshaQ1Ok",
        "title": "Comparison between PlasmaKinetic System and Bipolarcoagulation in Laparoscopic Treatment of Patients with Infertility and Distal Tube Obstructed",
        "abstract": "Objective To compare the efficacy of PlasmaKinetic System and bipolar coagulation in laparoscopic salpingostomy in infertile women with distal tube obstruction.Methods From May 2004 to Octorber 2006 according to the extent of tube and pelvic lesion,64 patients of stage\u2161,stage\u2162 were treated with laparoscopic salpingostomy.32 cases were operated by plasma kinetic system(group A),and 32 cases were operated by bipolar coagulation(group B).The intraoperative stuation,postoperative stuation and total postoperative pregnancy rate were compared.Result There were no significiant differance between group A and group B in operation time,intraoperative blood loss,postoperative analexsufflation time,and the length of postoperative hospitalization.The pregnancy rate was 56.67% in group A,27.59% in group B with significant difference(\u03c72=5.107,P <0.05).Conclusion Laprascopy salpigostery were treated in infertile women with distal tube obstution at stage \u2161,stage\u2162.The total pregnancy rate in group A showed better than that in group B.In laparoscopic salpingostomy,PlasmaKinetic System can benefit in restoring tube,ovarian anatomy and function.",
        "keywords": [
            "Infertility",
            "PlasmaKinetic System",
            "Salpingostomy",
            "Laparoscopy"
        ],
        "authors": [
            {
                "name": "CAO Qiong",
                "org": "Department of Obsterics and Gynecology,the Second People's Hospital of Foshan,Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Department of Obsterics and Gynecology,the Second People's Hospital of Foshan,Foshan ,China"
            },
            {
                "name": "WEN Zhong-yong",
                "org": "Department of Obsterics and Gynecology,the Second People's Hospital of Foshan,Foshan ,China"
            }
        ],
        "venue": "Clinical Medical Engineering",
        "year": 2009
    },
    "zZqOI40b": {
        "id": "zZqOI40b",
        "title": "Effect of Corpus Luteum Removal During Laparoscopic Conservative Surgery for Tubal Pregnancy",
        "abstract": "Objective To evaluate the efficacy of stripping the corpus luteum during laparoscopic conservative surgery for tubal pregnancy in the prevention of recurrent ectopic pregnancy.Methods From January 2006 to December 2008,142 women with tubal pregnancy received laparoscopic conservative surgery in our hospital.Among the patients,the corpus luteum was stripped in 77 cases(group A),the rest 65 patients were set as a control group without stripping the corpus luteum(group B).The outcomes of the two groups were compared.Results No significant difference was observed in operation time and blood loss between the two groups [group A vs.group B:(40\u00b116)min vs.(35\u00b115)min,t=1.909,P=0.058;and(50\u00b130)ml vs.(48\u00b130)ml,t= 0.396,P=0.693].Whereas,group A showed significant quicker recovery time of serum \u03b2-hCG concentration [(12\u00b12)d vs.(21\u00b17)d,t=-10.656,P=0.000],and lower rate of recurrent ectopic pregnancy [1.3%(1/77)vs.12.3%(8/65),\u03c72=5.461,P=0.019].Conclusions Removal of the corpus luteum during laparoscopic conservative surgery for tubal pregnancy is effective in eliminating residual tropholdastic cells,so that decrease the serum level of \u03b2-hCG and thus prevent recurrent ectopic pregnancy.",
        "keywords": [
            "Tubal pregnancy",
            "Laparoscopic conservative surgery",
            "Corpus luteum strip"
        ],
        "authors": [
            {
                "name": "Huang Huixiang",
                "org": ".Department of Obstetrics and Gynecology,Ji'an First People's Hospital,Ji'an ,China"
            },
            {
                "name": "Huang Shimin",
                "org": ".Department of Obstetrics and Gynecology,Ji'an First People's Hospital,Ji'an ,China"
            },
            {
                "name": "Huang Hao",
                "org": ".Department of Obstetrics and Gynecology,Ji'an First People's Hospital,Ji'an ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2010
    },
    "QHzE5ztP": {
        "id": "QHzE5ztP",
        "title": "Laparoscopic Sentinel Lymph Nodes Biopsy in Patients with Early-Stage Cervical Cancer",
        "abstract": "Objective To investigate the feasibility of sentinel lymph node(SLN) biopsy by laparoscopy in patients with early-stage cervical cancer,and its accuracy for predicting pelvic lymph nodes metastasis.Methods A total of 26 patients with early-stage cervical cancer were enrolled in this study.Laparoscopic bilateral pelvic lymphadenectomy and radical hysterectomy were carried out in all the cases.During the operation,4 ml of methylene blue dye(1%) were injected into the cervix at 4 sites around the tumor.Both the blue-dyed lymph nodes and the other resected tissues were removed for pathological examination by HE staining.The blue-dyed lymph node was considered as SLNs,and the pathological results of all the removed pelvic lymph nodes were set as a gold standard,based on which the accuracy and false-negative rate of SLN biopsy,as well as the distribution of the SLN were determined.Results Of the 26 cases,a total of 51 SLNs were found in 23 patients(88.5%),among which 6 patients had 1 SLN,9 had 2,6 had 3,1 had 4,and 1 had 5;65.2%(15) of the patients had bilateral SLN.Five of the 26 patients(19.2%) showed pelvic lymph nodes metastases.In the 23 patients diagnosed as having SLN,3 had metastases in the SLNs(totally 6 SLNs were involved,2 of the 3 cases had the metastasis both in the SLN and pelvic lymph nodes,the other had the metastasis only in the SLN).In one patient,the biopsy was negative in SLN,but positive in the pelvic lymph nodes.In this series,the accuracy,sensitivity,specificity and negative predictive value of SLN biopsy were 95.7%(22/23),75%(3/4),100%(19/19),and 95%(19/20),respectively.There was a correlation between SLNs and pelvic lymph nodes status(\u03ba=0.832).Conclusions It is feasible to accurately detect SLNs using laparoscopic SLNs biopsy in patients with early-stage cervical cancer.The method is capable of predicting the disease,as well as the metastasis of local lymph nodes.",
        "keywords": [
            "Sentinel lymph node",
            "Methylene blue dye",
            "Laparoscopy",
            "Cervical neoplasms"
        ],
        "authors": [
            {
                "name": "Huang Yi",
                "org": ",et al.Department of Obstetrics and Gynecology,Foshan Second People's Hospital,Foshan ,China"
            },
            {
                "name": "Huang Hao",
                "org": ",et al.Department of Obstetrics and Gynecology,Foshan Second People's Hospital,Foshan ,China"
            },
            {
                "name": "Zhang Zhicheng",
                "org": ",et al.Department of Obstetrics and Gynecology,Foshan Second People's Hospital,Foshan ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2008
    },
    "0tQmT2P4": {
        "id": "0tQmT2P4",
        "title": "The distribution and possible role of ERK8 in mouse oocyte meiotic maturation and early embryo cleavage.",
        "abstract": "It is well known that extracellular signal-regulated kinase 8 (ERK8) plays pivotal roles in various mitotic events. But its physiological roles in oocyte meiotic maturation remain unclear. In this study, we found that although no specific ERK8 signal was detected in oocyte at the germinal vesicle stage, ERK8 began to migrate to the periphery of chromosomes shortly after germinal vesicle breakdown. At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, ERK8 was stably detected at the spindles. By taxol treatment, we clarified that the ERK8 signal was stained on the spindle fibers as well as microtubule asters in MI and MII oocytes. In fertilized eggs, the ERK8 signal was not observed in the two pronuclei stages. At prometaphase, metaphase, and anaphase of the first mitosis, ERK8 was detected on the mitotic spindle. ERK8 knock down by antibody microinjection and specific siRNA caused abnormal spindles, failed chromosome congression, and decreased first polar body extrusion. Taken together, our results suggest that ERK8 plays an important role in spindle organization during mouse oocyte meiotic maturation and early embryo cleavage.",
        "keywords": [
            "mtoc",
            "embryo"
        ],
        "authors": [
            {
                "name": "Yang Shang-Wu",
                "org": "Center for Reproductive Medicine, Department of Ob/Gy, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China."
            },
            {
                "name": "Huang Hao",
                "org": ""
            },
            {
                "name": "Gao Chen",
                "org": ""
            },
            {
                "name": "Chen Lei",
                "org": ""
            },
            {
                "name": "Qi Shu-Tao",
                "org": ""
            },
            {
                "name": "Lin Fei",
                "org": ""
            },
            {
                "name": "Wang Jian-Xin",
                "org": ""
            },
            {
                "name": "Hou Yi",
                "org": ""
            },
            {
                "name": "Xing Fu-Qi",
                "org": ""
            },
            {
                "name": "Sun Qing-Yuan",
                "org": ""
            }
        ],
        "venue": "Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada",
        "year": 2013
    },
    "fddhMEji": {
        "id": "fddhMEji",
        "title": "Clinical Analysis of Perioperative Management of 120 Elderly Gynecological Patients",
        "abstract": "Objective To study the possibility of gynecologic surgery in the elderly woman.Methods The perioperative data of 120 aged patients with gynecologic surgery were analyzed retrospectively.Results The data showed that senile women were easy to suffer from hypertension,and diabetes mellitus.The common gynecologic surgery indications for elder women were prolapse of uterus(35.0%),gynecologic malignant tumor(31.7%) and benign tumor(33.3%).The urinary infection,pulmonary infection and wound split were common after operation.Conclusion The full preparation before operation,suitable anesthesia and operation management,and careful monitoring during and after operation will help the senile women pass safely through the perioperative.",
        "keywords": [
            "Modus operandi",
            "Diabetes mellitus",
            "Perioperative period",
            "Senile women",
            "Hypertension"
        ],
        "authors": [
            {
                "name": "ZHANG Rui",
                "org": ".Department of Gynecology,Nanhai Hospital Affiliated to Southern Medical University,Foshan ,Guangdong,China"
            },
            {
                "name": "HUANG Hao",
                "org": ".Department of Gynecology,Nanhai Hospital Affiliated to Southern Medical University,Foshan ,Guangdong,China"
            }
        ],
        "venue": "Chinese Journal of General Practice",
        "year": 2009
    },
    "ppIZzWpy": {
        "id": "ppIZzWpy",
        "title": "Clinical Study of 38 Cases of Bridge Type of Joint Circular Ligament Repair for Vaginal Fornix Prolapse",
        "abstract": "Objiective:Explore the feasibility and effectiveness of the reconstruction of the middlecomparment and posteriocomparment by applicating bridge type of joint circular ligament repair to treat the prolapsus of uterine and vaginal wall\u3001vaginal fornix.Methods:Of 38 patients with different degree defect of pelvic organ prolapse,doing vaginal hysterectomy and then vaginal wall repair simultaneously bridge type of joint circular ligament repair,useing Polypropylene patch to reinforce vaginal bladder\u3001rectum fascia while hanging the vaginal top with round the residual ligament,to complete the reconstruction of the middlecomparment and posteriocomparmen.According to the international association of urine control pelvic organ prolapse quantitative(POP-Q) dividing method,the evaluation of surgical effects.Results:Surgery for an average of 115min,bleeding,average for 100 ml.38 patients with vaginal vault prolapse all corrected.A median follow-up of 26 months,all did not appear vagina,shorten the distortion,vaginal vault prolapse,asexual life obstacle.Without relapse.Various symptoms experiment it 50% period.Conclusion:For uterine prolapse,vaginal vault prolapse,merger,the patients in the application of hysterectomy at bridge type of joint circular ligament repair of suspension after pelvic reconstruction,short-term effect stable,reduce the recurrence of may.",
        "keywords": [
            "Vaginal Fornix Prolapse(prolapsus of vaginal fornix)",
            "Circular Ligament",
            "Mesh(Patch)",
            "Reconstruction of the Middlecomparment and Posteriocomparment"
        ],
        "authors": [
            {
                "name": "LUN Cai-xia",
                "org": "The People Hospital of Nanhai District,Guangdong,Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "The People Hospital of Nanhai District,Guangdong,Foshan ,China"
            },
            {
                "name": "TIAN Qiao",
                "org": "The People Hospital of Nanhai District,Guangdong,Foshan ,China"
            },
            {
                "name": "WANG Xiao-jie",
                "org": "The People Hospital of Nanhai District,Guangdong,Foshan ,China"
            }
        ],
        "venue": "Proceeding of Clinical Medicine",
        "year": 2010
    },
    "WIJIfday": {
        "id": "WIJIfday",
        "title": "Impact of Hysteroscopy on Peritoneal Cytology in Patients with Endometrial Carcinoma",
        "abstract": "Objective To explore the accuracy of hysteroscopy as a diagnosis for endometrial carcinoma and to determine if the procedure increase the rate of positive peritoneal cytology in the patients. Methods The peritoneal cytology of 36 patients with endometrial carcinoma diagnosed by D&C or hysteroscopy was retrospectively analyzed. Results The peritoneal cytology was positive in 1 (5.9%) of the 17 cases diagnosed by D&C and 2 (10.5%) of the 19 cases diagnosed by hysteroscopy (P=1.000). Based on the pathological examination,the accuracy of D&C was 52.9% (9/17),which was significantly lower than that of hysteroscopy [89.5% (17/19),P=0.025]. In the cases with stage \u2160 endometrial carcinoma,the diagnostic accordance rate of hysteroscopy was 85.7% (12/14),while that of the D&C was 42.9% (6/14,P=0.040). The 36 patients were followed up for 2 months to 4 and a half year (over 1 year in 28 cases). One patient with \u2162c stage carcinoma died of recurrent tumor in 2 years after the treatment. Conclusion Hysteroscopy shows higher diagnosis accuracy with no evidence indicating an increased rate of positive peritoneal cytology compared to D&C.",
        "keywords": [
            "Peritoneal cytology",
            "Hysteroscopy",
            "Endometrial carcinoma"
        ],
        "authors": [
            {
                "name": "Li Mojuan",
                "org": ".Department of Gynecology and Obstetrics,Hospital of Nanhai District,Foshan ,China"
            },
            {
                "name": "Huang Hao",
                "org": ".Department of Gynecology and Obstetrics,Hospital of Nanhai District,Foshan ,China"
            },
            {
                "name": "Wen Zhongyong",
                "org": ".Department of Gynecology and Obstetrics,Hospital of Nanhai District,Foshan ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2009
    },
    "LToI8ZFq": {
        "id": "LToI8ZFq",
        "title": "Cortical granule change and spontaneous parthenogenetic activation during mouse oocytes aging",
        "abstract": "Objective: To explore the cortical granule (CG) change and parthenogenetic activation during mouse oocyte aging. Methods: Female mice, 8-10 weeks of age, were induced to superovulation with pregnant mare serum gonadotropin (PMSG; 10U, i.p.) followed 48 h later by hCG (10 U, i.p.). Oocytes were retrieved at different time intervals (MII+0h, +6h, +12h, +18h) (in vivo aging) or MII+0h oocytes cultured for different time periods (+6h, +12h, +18h) (in vitro aging). CG distribution and release were assessed by fluorescene isothiocyanate-labelled Lens culinaris agglutinin (FITC-LCA) staining and laser confocal microscopy. Spontaneous parthenogenetic activation and fragmentation of oocytes were observed after anther 8h of culture of different in vivo aging groups. Results: Spontaneous cortical granule exocytosis (CEG) and CG inward movement rates in MII+12h, MII+18h groups were statistically higher than those in MII+0h, MII+6h groups in both in vivo and in vitro aging oocytes. Spontaneous CGE and CG inward movement in M+18h group was lower in in-vitro aging group than those of in vivo aging counterpart. Spontaneous parthenogenetic activation and oocyte fragmentation ratios after further 8h of culture were higher in MII+12h,MII+18h groups than those in MII+0h, MII+6h groups. Conclusion: Spontaneous CGE and CG inward movement increased during oocyte aging both in vivo and in vitro. There were also increased parthenogenetic activation and oocyte fragmentation ratios as oocyte aged. All these may cause the low fertility of aged oocyte. Spontaneous CGE and CG inward movement may be accelerated by maternal environment changes.",
        "keywords": [
            "Oocyte",
            "Aging",
            "Cortical granule",
            "Mouse",
            "Parthenogenetic activation"
        ],
        "authors": [
            {
                "name": "Yang Shangwu",
                "org": "Center of Reproductive Medicine, Southern Hospital Affiliated to Southern Medical university, Guangzhou ;Nanhai Hospital Affiliated to Southern Medical university"
            },
            {
                "name": "Huang Hao",
                "org": "Nanhai Hospital Affiliated to Southern Medical university"
            },
            {
                "name": "Wang Xiaojie",
                "org": "Nanhai Hospital Affiliated to Southern Medical university"
            },
            {
                "name": "Zhu Xiulan",
                "org": "Center of Reproductive Medicine, Southern Hospital Affiliated to Southern Medical university, Guangzhou "
            },
            {
                "name": "Xiu Liangchang",
                "org": " School of Public Health, Guangdong Medical University."
            },
            {
                "name": "Xing Fuqi",
                "org": "Center of Reproductive Medicine, Southern Hospital Affiliated to Southern Medical university, Guangzhou "
            }
        ],
        "venue": "Chinese Journal of Family Planning",
        "year": 2012
    },
    "fsHbW8Ft": {
        "id": "fsHbW8Ft",
        "title": "Effect of Laparoscopy on P-Selectin, D-Dimer and von Willebrand Factor",
        "abstract": "Objective To investigate the influence of gynaecological laparoscopy operation on P-selectin, D-dimer and von Willeband factor (vWF), and evaluate the risk factors of lower limb deep venous thrombosis (LDVT). Methods 60 patients were randomized into laparoscopic resection group (30 cases) and open abdominal incision group (30 cases). P-selectin, D-dimer and vWF were detected at preoperation, postoperative 10 min and 24 h in the two groups. Results P-selectin, D-dimer and vWF all significantly increased after operation in both groups compared with those before operation with statistically significant difference (P <0.05), but without statistical difference at the same period between two groups. Conclusions P-selectin, D-dimer and vWF are increased by gynaecological laparoscopy operation which can raise the risk of venous thrombosis, but the risk has no difference compared with open abdominal incision operation.",
        "keywords": [
            "von Willebrand factor",
            "Deep venous thrombosis",
            "Laparoscopy",
            "P-selectin",
            "D-Dimer",
            "Ovariancyst"
        ],
        "authors": [
            {
                "name": "ZHANG Rui",
                "org": "Nahai Hospital Aaffiliated to Southern Medical University, Foshan , China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nahai Hospital Aaffiliated to Southern Medical University, Foshan , China"
            },
            {
                "name": "LI Lifang",
                "org": "Nahai Hospital Aaffiliated to Southern Medical University, Foshan , China"
            },
            {
                "name": "ZHAO Xuefeng",
                "org": "Nahai Hospital Aaffiliated to Southern Medical University, Foshan , China"
            },
            {
                "name": "WANG Xiaojie",
                "org": "Nahai Hospital Aaffiliated to Southern Medical University, Foshan , China"
            },
            {
                "name": "LIU Jin",
                "org": "Nahai Hospital Aaffiliated to Southern Medical University, Foshan , China"
            }
        ],
        "venue": "Clinical Medicine & Engineering",
        "year": 2012
    },
    "wqgCPOKz": {
        "id": "wqgCPOKz",
        "title": "Preliminary Study on Childbirth Course with Different Dose of Phloroglucinol",
        "abstract": "Objective:To observe the effects of different dose of Phloroglucinol on childbearing course.Methods:Sixty-six pregnant women were randomly divided into three groups according to Phloroglucinol dosage: 160 mg group(n=20),80 mg group(n=22),and 40 mg group(n=24).The labor time,fetal distress,and postpartum hemorrhage were evaluated in three groups.Results:\u2460The mean time of active phase was 53.25\u00b113.31 min,82.73\u00b147.23 min,and 120.63\u00b143.52 min in 160 mg group,80 mg group and 40 mg group,respectively.There were significant difference among the three groups(P<0.01) \u2461The total time of first stage of labor were 382.25\u00b1146.63 min,358.64\u00b1176.09 min,and 603.75\u00b1218.41 min in 160 mg group,80 mg group,and 40 mg group,respectively.There was no significant difference between the former two groups(P>0.05),but differed from 40 mg group(P<0.01).\u2462There were no significant difference in the fetal suffocation,newborn weight,and amount of postpartum hemorrhage among the three groups.Conclusions:Phloroglucinol can effectively improve labor progress and its dose is positive correlation with shorten active phase of labor.To obtain predominant effect,160 mg Phloroglucinol is preferred by intravenous injection.",
        "keywords": [
            "Phloroglucinol",
            "Labor stages",
            "Childbearing"
        ],
        "authors": [
            {
                "name": "DONG Julang",
                "org": "Fushan Second People's Hospital,Fushan Guangdong ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Fushan Second People's Hospital,Fushan Guangdong ,China"
            },
            {
                "name": "CAO Q",
                "org": "Fushan Second People's Hospital,Fushan Guangdong ,China"
            }
        ],
        "venue": "Journal of Practical Obstetrics and Gynecology",
        "year": 2006
    },
    "YHGRipSJ": {
        "id": "YHGRipSJ",
        "title": "Comparison of Two Procedures for Laparoscopic Hysterectomy",
        "abstract": "Objective To compare the clinical value of laparoscopic-assisted vaginal hysterectomy (LAVH) and total laparoscopic hysterectomy (TLH). Methods From January 2004 to August 2006, 128 cases of LAVH (LAVH group) and 42 cases of TLH (TLH group) were analyzed retrospectively. All the patients had benign lesions. The operation time, intraoperative blood loss, postoperative hospital stay, and rate of postoperative complications were compared between the two groups. Results All the laparoscopic operations were completed without conversion to open surgery. No significant difference was found in the time to the first passage of gas, postoperative hospital stay, and rate of postoperative complications between the two groups (P>0.05). The mean operation time of the LAVH group was significantly shorter than that of the TLH group [(95.6\u00b118.2) minutes vs (112.9\u00b124.5) minutes, t=-4.883, P=0.000]; whereas, the blood loss in the LAVH group was significantly more than the TLH group [(73.8\u00b150.8) ml vs (49.8\u00b126.9) ml, t=2.926, P=0.004]. Conclusions Laparoscopic hysterectomy is safe and feasible. Both LAVH and TLH have advantages. TLH is more suitable to experienced doctors.",
        "keywords": [
            "Laparoscopic-assisted vaginal hysterectomy",
            "Clinical effect",
            "Total laparoscopic hysterectomy"
        ],
        "authors": [
            {
                "name": "Wen Zhongyong",
                "org": ".Department of Obstetrics and Gynecology, Second People\u2019s Hospital of Foshan, Foshan , China"
            },
            {
                "name": "Huang Hao",
                "org": ".Department of Obstetrics and Gynecology, Second People\u2019s Hospital of Foshan, Foshan , China"
            },
            {
                "name": "Huang Yi",
                "org": ".Department of Obstetrics and Gynecology, Second People\u2019s Hospital of Foshan, Foshan , China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2008
    },
    "mMBW9A2t": {
        "id": "mMBW9A2t",
        "title": "Placenta Increta: Diagnosis and Management (Report of Seven Cases and Rev of Literature)",
        "abstract": "Objective To summarize and investigate the Pathoilogy, diagnosis and treatment of Placenta accreta. Methods Seven Placenta increta cases were analyzed retrospectively and relative literatures were reviewed. Results Three of seven placenta increta cases received emergency hysterectomy and residuary 4 cases were treated successfully with suture and compression hemostasis. No one died. Conclusions Early prenatal diagnosis of Placenta accreta is important for improving prognosis of the disease. Emergency hysterectomy is usually inevitable for treating serious hemorrhage; meanwhile conservative treatment is carefully adopted for cases of non-emergency cases and of eagerness for fertility. Because the delayed DIC may take place in conservative therapy, careful follow-up may be required until the entire placenta has been resorbed or discharged.",
        "keywords": [
            "Placenta",
            "Accreta"
        ],
        "authors": [
            {
                "name": "DONG Ju-lang",
                "org": " Department of Gynaecology and Obstetrics, FoShan Second People's Hospital, FoShan, Guang Dong  China"
            },
            {
                "name": "HUANG Hao",
                "org": " Department of Gynaecology and Obstetrics, FoShan Second People's Hospital, FoShan, Guang Dong  China"
            }
        ],
        "venue": "Hainan Medical Journal",
        "year": 2006
    },
    "83KYc59d": {
        "id": "83KYc59d",
        "title": "Comparative Analysis of Effectiveness and Health Economics of Myomectomy Using Laparoscopy and Laparotomy",
        "abstract": "Laparoscopic myomectomy has been a commonly used procedure of resecting myomas and preserving uterine,due to its well recognized advantages,such as minimally invasiveness,less blood loss,and rapid recovery.However,there are some disputes in its surgical indications and health economics.The surgical indications,therapeutic effects and health economics of both procedures are reviewed in this article.",
        "keywords": [
            "Health economics",
            "Myomectomy",
            "Laparoscopy"
        ],
        "authors": [
            {
                "name": "HUANG Shi-min",
                "org": "Guangdong Medical College,Zhanjian ,China;Department of Gynecology and Obstetrics,People's Hospital of Nanhai District,Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Department of Gynecology and Obstetrics,People's Hospital of Nanhai District,Foshan ,China"
            }
        ],
        "venue": "Medical Recapitulate",
        "year": 2010
    },
    "mTd0fdWw": {
        "id": "mTd0fdWw",
        "title": "Postoperative Combined Medicine Therapy to Patients with Endometriosis in Pregnancy",
        "abstract": "Objective:To investigate the effect on pregnancy after laparoscopy in treating mild-severe endometriosis combined with gestrinone or gonadotropin releasing hormone analogue,GnRH-a.Methods:A retrospective analysis on the clinical material of 112 women with mild-severe endometriosis,who were treated in our hospital from January 2009 to December 2010.All paitents choose different medicine by themselves,to compare the recurrence rate,the natural pregnancy rate and incidence of adverse reactions,etc.Results:All patients were confirmed pathological diagnosis of endometriosis.Follow-up to September 2011,gestrinone,triptorelin group recurrence rates were 3.85%,3.33%,no significant difference between the two groups(P>0.05).The natural conception rate of Gestrinone group was 56.25%,lower than triptorelin group,no significant difference between the two groups(P>0.05).Conclusion:Postoperative combined Gestrinone or triptorelin can significantly reduce the recurrence rate of endometriosis,but their natural conception rate remain to be seen.",
        "keywords": [
            "Iaparoscopic",
            "Triptorelin",
            "Endometriosis",
            "Gestrinone"
        ],
        "authors": [
            {
                "name": "HUANG Shimin",
                "org": ".Department of Gynecology and Obstetrics,The People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            },
            {
                "name": "WEN Zhongyong",
                "org": ".Department of Gynecology and Obstetrics,The People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            },
            {
                "name": "HUANG Hao",
                "org": ".Department of Gynecology and Obstetrics,The People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            }
        ],
        "venue": "The Journal of Medical Theory and Practice",
        "year": 2012
    },
    "KTveq2He": {
        "id": "KTveq2He",
        "title": "Current Status of Research on Canceration of Endometriosis",
        "abstract": "Endometriosis is a common benign gynecologic disease with extensive clinical and pathological features of pleomorphic,similar biological behavior of malignant tumors.It is reported that endometriosis may experience a series of pathologic change courses and finally become a malignant tumor.Currently the etiology and pathogenesis of malignant transformation is not clear.This article reviewed current status of research on occurrence and development of canceration of endometriosis including the incidence,risk factors,clinical manifestations,diagnosis and the relationship between with atypical endometriosis and canceration of endometriosis.",
        "keywords": [
            "Canceration",
            "Endometriosis",
            "Risk factor"
        ],
        "authors": [
            {
                "name": "HU Bi-hong",
                "org": "Department of Obstetrics and Gynecology,Nanhai Hospital of Southern Medical University,Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Department of Obstetrics and Gynecology,Nanhai Hospital of Southern Medical University,Foshan ,China"
            }
        ],
        "venue": "Medical Recapitulate",
        "year": 2011
    },
    "UzEXjKJv": {
        "id": "UzEXjKJv",
        "title": "The Value of Laparoscope to the Transvaginal Hysterectomy for the Non-prolapsed Uterus",
        "abstract": "Objective:To explore the feasibility of laparoscope to the transvaginal hysterectomy for the non-prolapsed uterus.Methods:78 cases under transvaginal hysterectomy with or without laparoscopic help in our hospital from Feb 2007 to Oct 2010 were analyzed retrospectively.40cases were under laparoscopic assisted transvaginal hysterectomy(LAVH),and 38 cases were under total transvaginal hysterectomy(TVH).The duration of operation,amount of bleeding during operation,postoperative anal exhaust time,highest body temperature,hospitalization time,and pain were compared between the two groups.Results:Both The duration of operation and the amount of bleeding during operation in LAVH group are statistically lower than those in TVH group.No statistiacally differences were found in postoperative anal exhaust time,highest body temperature and hospitalization time between two groups.Conclusion:With the characteristics of easy grasping,minimal Invasion,and lower complication,LAVH is a relatively good one for hysterectomy,especially appliable for the patients with pelvic surgery history,or hard to expose incision and for the doctors with less experiences of transvaginal surgery.",
        "keywords": [
            "Transvaginal hysterectomy",
            "Non-prolapsed uterus",
            "Laparoscope"
        ],
        "authors": [
            {
                "name": "WANG Xiao-jie",
                "org": ". Nanhai People\u2019s Hospital,Foshan ,China."
            },
            {
                "name": "YANG Shang-wu",
                "org": ". Nanhai People\u2019s Hospital,Foshan ,China."
            },
            {
                "name": "HUANG Hao",
                "org": ". Nanhai People\u2019s Hospital,Foshan ,China."
            }
        ],
        "venue": "Medical Innovation of China",
        "year": 2012
    },
    "P9FenOig": {
        "id": "P9FenOig",
        "title": "A Clinical Analysis of 36 Cases on Combined Use of Hysteroscopy and Laparoscopy in Diagnosis and Treatment of Endometrial Carcinoma",
        "abstract": "Objective To explore the effect of hysteroscopy as a diagnosis for endometrial carcinoma and to determine the clinical outcome of laparoscopic surgery in endometrial carcinoma.Methods 36 patients with endometrial carcinoma had enrolled in the retrospective analysis.Results The peritoneal cytology was positive in 1(5.9%)of the 17 cases diagnosed by D&C and 2(10.5%)of the 19 cases diagnosed by hysteroscopy(P=1.000).Based on the pathological examination,the accuracy of D&C was 64.7%(11/17),which was significantly lower than that of hysteroscopy[94.7%(18/19),P=0.028].In the cases with stage \u2160 endometrial carcinoma,the diagnostic accordance rate of hysteroscopy was 92.9%(13/14),while that of the D&C was 57.1%(8/14,P=0.074).As compared with the open group(7 cases),the laparoscopic group(29 cases)presented a significant difference in blood loss(121.7\u00b179.6 vs 271.4\u00b199.4ml,P=0.0060),earlier time to first passing flatus(38.6\u00b18.5h vs 51.6\u00b18.6h,P=0.0057),similar operating time(245.0\u00b171.3 min vs 260.0\u00b173.9 min,P=0.6228),similar number of lymph nodes yielded(22.3\u00b17.2 vs 21.3\u00b19.0,P=0.8205),and similar days of average post-operative hospital stay(10.2\u00b12.6 vs 12.1\u00b12.1,P=0.0669).During follow-up period,only one case in laparotomic group had a relapse and died finally.Conclusion The accuracy of hysteroscopy used in the diagnosis of endometrial carcinoma is good,but the dispute still exits that it may facilitate the tumor cell dissemination at present.Laparoscopic radical hysterectomy and pelvic lymphadenectomy may be an alternative treatment for endometrial carcinoma.",
        "keywords": [
            "endometrial carcinoma laparoscopy hysteroscopy dilatations and curettages(D&C)"
        ],
        "authors": [
            {
                "name": "Li mojuan",
                "org": "Department of gynaecology and obstetrics,the second affiliated hospital of Guangdong medical university,Zhanjiang ,China"
            },
            {
                "name": "Zhong peigen",
                "org": "Department of gynaecology and obstetrics,the second affiliated hospital of Guangdong medical university,Zhanjiang ,China"
            },
            {
                "name": "Lin huanzhu",
                "org": "Department of gynaecology and obstetrics,the second affiliated hospital of Guangdong medical university,Zhanjiang ,China"
            },
            {
                "name": "Gao hongmei",
                "org": "Department of gynaecology and obstetrics,the second affiliated hospital of Guangdong medical university,Zhanjiang ,China"
            },
            {
                "name": "Huang hao",
                "org": "Department of gynaecology and obstetrics,the People's hospital of Foshan in Guangdong Province,Foshan ,China"
            }
        ],
        "venue": "Oncology Progress",
        "year": 2012
    },
    "35jc4U1M": {
        "id": "35jc4U1M",
        "title": "Laparoscopic Radical Hysterectomy with Preservation of the Pelvic Autonomic Nerve:Report of 10 Cases",
        "abstract": "Objective To investigate laparoscopic radical hysterectomy(LRH) with the pelvic autonomic nerve(PAN) being perserved on bladder function recovery. Methods From October 2008 to October 2009,42 patients with cervical cancer at stage \u2160A2-\u2160B1(26 cases) or endometrial carcinoma at stage \u2160B-\u2161A(16 cases) received LRH in our hospital.Of the cases,the PAN was preserved systematically in 10 patients(PAN group),the other 32 cases who had routine LRH were set as a control(Routine group).The postoperative bladder function of the two groups were compared. Results All the operations were completed under laparoscope.In the PAN group,the PAN was preserved unilaterally in 4 patients,bilaterally in 5,and failure in one.PAN group showed significantly shorter recovery time for bladder function than the Routine group [(9.2\u00b1 4.6) d vs.(15.2\u00b12.3) d,t=-5.440,P=0.000).There were 2 and 9 cases respectively in the PAN and Routine groups showed frequent urination and odynuria.The length of vaginal stump,USL,and CL were all less then 3 cm.No cancer cells were detected at the surgical resection margin. Conclusions Laparoscopic radical hysterectomy with the PAN preserved improves the recovery of the bladder function.Further studies are needed to observe long-term outcomes.",
        "keywords": [
            "Redical hysterectomy",
            "Laparoscopy",
            "Pelvic autonomic nerve preservation",
            "Cervical cancer",
            "Endometrial cancer"
        ],
        "authors": [
            {
                "name": "Wen Zhongyong",
                "org": ",et al.Department of Obstetrics and Gynecology,Nanhai People's Hospital,Southern Medical University,Nanhai ,China"
            },
            {
                "name": "Huang Shimin",
                "org": ",et al.Department of Obstetrics and Gynecology,Nanhai People's Hospital,Southern Medical University,Nanhai ,China"
            },
            {
                "name": "Huang Hao",
                "org": ",et al.Department of Obstetrics and Gynecology,Nanhai People's Hospital,Southern Medical University,Nanhai ,China"
            }
        ],
        "venue": "Chinese Journal of Minimally Invasive Surgery",
        "year": 2011
    },
    "iBYVy6kG": {
        "id": "iBYVy6kG",
        "title": "The Diagnostic Value of Vaginal Speculum in Cervical Pathological Changes",
        "abstract": "Objective: To evaluate the diagnostic value of vaginal speculum in cervical pathological changes.Method: 378 cases with cervical pathological changes underwent cervical cell test,vaginal speculum examination and pathological examination.Result: 63 cases were found abnormal in 378 cases through cervical cell test,accounting for 16.7%.We took biopsy with vaginoscopy.Then 319 cases were found with cervical chronic inflammation,59 cases with cervical intraepithelial neoplasia(CIN),1 cases with cervical carcinoma in situ and 4 cases with invasive carcinoma of cervix uteri,respectively accounting for 84.4%,15.6%,0.26%,1.06%.Conclusion: Vaginal speculum examination can help us take biospy more exactly,find cervical pathological changes and cervical cancer earlier,It's an accurate and reliable method for cervical disease diagnosis.",
        "keywords": [
            "Vaginal speculum",
            "Pathology examination",
            "Cervical pathological changes"
        ],
        "authors": [
            {
                "name": "YAN Ying",
                "org": "The Second People's Hospital of Foshan,Guangdong Foshan ,China"
            },
            {
                "name": "WANG Shu-qin",
                "org": "The Second People's Hospital of Foshan,Guangdong Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "The Second People's Hospital of Foshan,Guangdong Foshan ,China"
            }
        ],
        "venue": "Hebei Medicine",
        "year": 2006
    },
    "neidEZye": {
        "id": "neidEZye",
        "title": "Treatment of uterine prolaps by laparoscopic supracervical hysterectomy and reconstructing pelvic floor",
        "abstract": "Objective To evaluate the clinical efficacy of laparoscopic supracervical hysterectomy(LSH) and the uterus round ligament suspension plus uterosacral ligament shortening for treating uterine prolaps.Methods Eligible 18 patients with uterine prolaps undergoing operation of LSH and uterus round ligament suspension plus uterosacral ligament shortening served as research group,and basic data-matched 30 patients with uterine prolaps undergoing operation of traditional hysterectomy via vagina plus vaginal anterior and posterior wall repairing served as control group.The intraoperative and postoperative complications were obseved and compared.The followed-up time was 12 months(one time every 3 months),and postoperative vaginal vault prolaps,sexual life and so on were observed.Results All operations were smoothly carried out.The bleeding volume in operation and postoperative hospitalization time were lower in research group than those in control group(all P < 0.05).The total score of sexual life post operation was higher in research group than that in control group(P < 0.05).The incidence of vaginal length-shortening and vaginal sensation of dryness were lower in research group than those in control group(all P < 0.01).The incidence of vaginal vault prolaps,menopausal syndrome and urinary abnormality had not significant difference(all P > 0.05).Conclusions LSH combining with uterus round ligament suspension plus uterosacral ligament shortening is a better and trauma-small operative method to treate uterine prolaps for reconstructing pelvic floor.The patient's tolerance is good,and the short-term therapeutic efficacy is obvious.",
        "keywords": [
            "Reconstructing pelvic floor",
            "Laparoscopy",
            "Supracervical hysterectomy",
            "Round ligament suspension",
            "Uterosacral ligament shortening"
        ],
        "authors": [
            {
                "name": "HU Bi-hong",
                "org": ".Department of Obstetrics and Gynecology,Affiliated Nanhai Hospital,Southern Medical University,Foshan ,China"
            },
            {
                "name": "WEN Zhong-yong",
                "org": ".Department of Obstetrics and Gynecology,Affiliated Nanhai Hospital,Southern Medical University,Foshan ,China"
            },
            {
                "name": "HUANG Shi-min",
                "org": ".Department of Obstetrics and Gynecology,Affiliated Nanhai Hospital,Southern Medical University,Foshan ,China"
            },
            {
                "name": "HUANG Hao",
                "org": ".Department of Obstetrics and Gynecology,Affiliated Nanhai Hospital,Southern Medical University,Foshan ,China"
            }
        ],
        "venue": "Chinese Journal of Clinical Research",
        "year": 2010
    },
    "BA7hYOyx": {
        "id": "BA7hYOyx",
        "title": "Clinical Efficacy of Improved Laparoscopic Assisted Vaginal Hysterectomy",
        "abstract": "Objective:To investigate the improvement of laparoscopic assisted vaginal hysterectomy(laparoscopic assisted trasvaginal hysterectomy,LAVH) clinical efficacy.Methods:met the inclusion criteria for patients with total hysterectomy were randomly divided into three according to treatment group,which LAVH-\u2160 type 30 cases,LAVH-\u2162 type 28 cases,modified LAVH30 cases,observe and compare three surgical operative time,blood loss,intraoperative and postoperative complication rate,bowel function recovery time,and differences in postoperative hospital stay.Results:The operation time,blood loss,LAVH-\u2160 type group were(85.50\u00b111.68) min,(86.67\u00b120.36) ml,LAVH-\u2162 type group(90.53\u00b110.95) min,(76.89\u00b114.72) ml,modified Type LAVH group(90.53\u00b110.95) min,(76.89\u00b114.72) ml,three groups were statistically significant differences(P<0.05).Anal discharge recovery time,postoperative hospital stay,postoperative complication rate,three groups no significant difference(P>0.05).Conclusion:modified LAVH is simple,safe,shorter operative time,less blood loss,is clinically available,a new LAVH surgical.",
        "keywords": [
            "Hysterectomy",
            "Complications",
            "Modified",
            "Laparoscopy"
        ],
        "authors": [
            {
                "name": "HUANG Hao",
                "org": ",et al.Obstetrics and Gynecology,The People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            },
            {
                "name": "WEN Zhongyong",
                "org": ",et al.Obstetrics and Gynecology,The People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            },
            {
                "name": "WANG Xiaojie",
                "org": ",et al.Obstetrics and Gynecology,The People's Hospital of Nanhai District,Foshan City,Guangdong Province "
            }
        ],
        "venue": "The Journal of Medical Theory and Practice",
        "year": 2011
    },
    "nDQe8Ip4": {
        "id": "nDQe8Ip4",
        "title": "Phloroglucinol impact on childbirth process,plasma cortisol/ratio of glucose and insulin",
        "abstract": "Objective The current study was designed to observe the effects of phloroglucinol on child birth process,plasma cortisol and ratio of glucose/insulin.MethodsFifty-five primiparae were randomly divided into two groups,phloroglucinol group(n=26)and control group(n=29).The labor time,fetal distress and postpartum hemorrhage condition between the two groups were evaluated,meanwhile diversity of plasma cortisol and ratio of glucose/insulin were also observed.Results\u2460 The mean time of full dilation of cervix was 86.23\u00b145.85 min in study group,and 172.86\u00b1144.32 min was found in control group(P<0.05).\u2461 Comparing to 86.17\u00b130.27 minutes during second stage of control group,only 63.12\u00b129.47 min was needed to finish second stage in phloroglucinol group(P<0.05).\u2462 There are no significant difference in the fetal suffocation,weight of newborns and degree of postpartum hemorrhage between the two groups,meanwhile no obvious difference between two groups in plasma cortisol and ratio of glucose/insulin were observed.ConclusionPhloroglucinol can effectively improve cervical dilation and decrease labor time,has no adverse effect to puerperas and fetus.Phloroglucinol has no effect on normal stress reaction of puerperas.",
        "keywords": [
            "plasma cortisol",
            "glucose/insulin",
            "childbearing",
            "phloroglucinol"
        ],
        "authors": [
            {
                "name": "DONG Ju-lang",
                "org": ".Department of Gynecology,FuShan second people's Hospital,GangDong,China."
            },
            {
                "name": "HUANG Hao",
                "org": ".Department of Gynecology,FuShan second people's Hospital,GangDong,China."
            }
        ],
        "venue": "Chinese Journal of Obstetrics & Gynecology and Pediatrics",
        "year": 2007
    },
    "MqQmlkXq": {
        "authors": [
            {
                "name": "He Ping Yang",
                "org": "Department of Neurology, Xiangya Second Hospital, Central South University"
            },
            {
                "name": "Da Peng Wu",
                "org": "Department of Neurology, Xiangya Second Hospital, Central South University"
            },
            {
                "name": "Xiao Jie Zhang",
                "org": "Department of Psychiatry, Xiangya Second Hospital, Central South University"
            },
            {
                "name": "Xiang Wang",
                "org": "Department of Neurology, Xiangya Second Hospital, Central South University"
            },
            {
                "name": "Yi Peng",
                "org": "Department of Neurology, Xiangya Second Hospital, Central South University"
            },
            {
                "name": "Zhi Ping Hu",
                "org": "Department of Neurology, Xiangya Second Hospital, Central South University"
            }
        ],
        "title": "Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/ phosphatidylinositol-3-kinase/protein kinase B pathway",
        "abstract": "Telencephalin is a neural glycoprotein that reduces apoptosis induced by amyloid beta protein in the human neural tumor cell line PAJU. In this study, we examined the role of the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway in this process. Western blot analysis demonstrated that telencephalin, phosphorylated ezrin/radixin/moesin and phosphatidylinositol- 3-kinase/protein kinase B were not expressed in PAJU cells transfected with empty plasmid, while they were expressed in PAJU cells transfected with a telencephalin expression plasmid. After treatment with 1.0 nM amyloid beta protein 42, expression of telencephalin and phosphorylated phosphatidylinositol-3-kinase/protein kinase B in the transfected cells gradually diminished, while levels of phosphorylated ezrin/radixin/moesin increased. In addition, the high levels of telencephalin, phosphorylated ezrin/radixin/moesin and phosphatidylinositol-3-kinase/protein kinase B expression in PAJU cells transfected with a telencephalin expression plasmid could be suppressed by the phosphatidylinositol-3-kinase inhibitor LY294002. These findings indicate that telencephalin activates the ezrin/radixin/moesin family/phosphatidylinositol-3-kinase/protein kinase B pathway and protects PAJU cells from amyloid beta protein-induced apoptosis.",
        "keywords": [
            "Amyloid beta protein",
            "Ezrin/radixin/moesin family proteins/phosphatidylinositol-3-kinase/protein kinase B signal transduction",
            "Neural regeneration",
            "Telencephalin/intercellular adhesion molecule 5"
        ],
        "venue": "Neural Regeneration Research",
        "year": 2012,
        "id": "MqQmlkXq"
    },
    "6VsXB8qQ": {
        "authors": [
            {
                "name": "Wei Zhao",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Samuel Law",
                "org": "Department of Psychiatry, University of Toronto"
            },
            {
                "name": "Xingwei Luo",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Wendy Chow",
                "org": "Department of Psychiatry, University of Toronto"
            },
            {
                "name": "Jinqiang Zhang",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Ye Zhu",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Shiyan Liu",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Xiaoqian Ma",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Shuqiao Yao",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Xiang Wang",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            }
        ],
        "title": "First adaptation of a family-based ACT model in Mainland China: A pilot project",
        "abstract": "Objective: This study reports findings from a preliminary evaluation of the first implementation of the assertive community treatment (ACT) model in mainland China. Methods: Over six months, the pilot study compared a group of patients (N=15) and family caregivers who received ACT services with a control group (N=16) who received standard community services. Data on hospitalization days, relapse frequency, psychiatric symptoms, social and vocational functioning, general mental health status, family burden, and level of social support for family caregivers were examined. Results: ACT patients had no admissions, compared with two in the control group; they also had significantly lower psychopathology and higher social functioning scores. No significant differences in outcome measures for family caregivers were found. Conclusions: The study found preliminary support for implementing ACT in mainland China. Implementation could contribute to reducing admission and psychopathology and improving social functioning. Further research on ways to enhance family caregivers' experience is warranted.",
        "keywords": [
            ""
        ],
        "venue": "Psychiatric Services",
        "year": 2015,
        "id": "6VsXB8qQ"
    },
    "K8MGrpBS": {
        "authors": [
            {
                "name": "Jibiao Zhang",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Junling Gao",
                "org": "Centre of Buddhists Studies, University of Hong Kong"
            },
            {
                "name": "Huqing Shi",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Bingsheng Huang",
                "org": "Department of Biomedical Engineering, School of Medicine, Shenzhen University"
            },
            {
                "name": "Xiang Wang",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Weijun Situ",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Weixiong Cai",
                "org": "Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice"
            },
            {
                "name": "Jinyao Yi",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Xiongzhao Zhu",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Shuqiao Yao",
                "org": "Medical Psychological Institute, Second Xiangya Hospital, Central South University"
            }
        ],
        "title": "Sex differences of uncinate fasciculus structural connectivity in individuals with conduct disorder",
        "abstract": "Conduct disorder (CD) is one of the most common behavior disorders in adolescents, such as impulsivity, aggression, and running from school. Males are more likely to develop CD than females, and two previous diffusion tensor imaging (DTI) studies have demonstrated abnormal microstructural integrity in the uncinate fasciculus (UF) in boys with CD compared to a healthy control group. However, little is known about changes in the UF in females with CD. In this study, the UF was illustrated by tractography; then, the fractional anisotropy (FA), axial diffusivity, mean diffusion, radial diffusivity (RD), and the length and number of the UF fiber bundles were compared between male and female patients with CD and between female patients with CD and female healthy controls, as well as between males with CD and healthy males. We found that males with CD showed significantly higher FA of the bilateral UF and significantly lower RD of the left UF when comparing with females with CD. Meanwhile, significantly higher FA and lower RD of the bilateral UF were also found in boys with CD relative to the male healthy controls. Our results replicated previous reports that the microstructural integrity of the UF was abnormal in boys with CD. Additionally, our results demonstrated significant gender effects on the UF of patients with CD, which may indicate why boys have higher rates of conduct problems than girls. \u00a9 2014 Jibiao Zhang et al.",
        "keywords": [
            ""
        ],
        "venue": "BioMed Research International",
        "year": 2014,
        "id": "K8MGrpBS"
    },
    "gZ5bhbfi": {
        "authors": [
            {
                "name": "Qingsen Ming",
                "org": ""
            },
            {
                "name": "Xiang Wang",
                "org": ""
            },
            {
                "name": "Qiaolian Chai",
                "org": ""
            },
            {
                "name": "Jinyao Yi",
                "org": ""
            },
            {
                "name": "Shuqiao Yao",
                "org": ""
            }
        ],
        "title": "Retinoid-related orphan receptor alpha (RORA) gene variation is associated with trait depression",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Psychiatry Research",
        "year": 2015,
        "id": "gZ5bhbfi"
    },
    "EyPhrdEi": {
        "authors": [
            {
                "name": "Bei Zhang",
                "org": "Medical Psychological Institute, The Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Pan Lin",
                "org": "Key Laboratory of Biomedical Information Engineering of Education Ministry, Institute of Biomedical Engineering, Xi\u2019an Jiaotong University"
            },
            {
                "name": "Huqing Shi",
                "org": "Department of Psychology, Shanghai Normal University"
            },
            {
                "name": "Dost \u00d6ng\u00fcr",
                "org": "Harvard Medical School and McLean Hospital"
            },
            {
                "name": "Randy P. Auerbach",
                "org": "Harvard Medical School and McLean Hospital"
            },
            {
                "name": "Xiaosheng Wang",
                "org": "Department of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University"
            },
            {
                "name": "Shuqiao Yao",
                "org": "Medical Psychological Institute, The Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Xiang Wang",
                "org": "Medical Psychological Institute, The Second Xiangya Hospital of Central South University"
            }
        ],
        "title": "Mapping anhedonia-specific dysfunction in a transdiagnostic approach: an ALE meta-analysis",
        "abstract": "Anhedonia is a prominent symptom in neuropsychiatric disorders, most markedly in major depressive disorder (MDD) and schizophrenia (SZ). Emerging evidence indicates an overlap in the neural substrates of anhedonia between MDD and SZ, which supported a transdiagnostic approach. Therefore, we used activation likelihood estimation (ALE) meta-analysis of functional magnetic resonance imaging studies in MDD and SZ to examine the neural bases of three subdomains of anhedonia: consummatory anhedonia, anticipatory anhedonia and emotional processing. ALE analysis focused specifically on MDD or SZ was used later to dissociate specific anhedonia-related neurobiological impairments from potential disease general impairments. ALE results revealed that consummatory anhedonia was associated with decreased activation in ventral basal ganglia areas, while anticipatory anhedonia was associated with more substrates in frontal-striatal networks except the ventral striatum, which included the dorsal anterior cingulate, middle frontal gyrus and medial frontal gyrus. MDD and SZ patients showed similar neurobiological impairments in anticipatory and consummatory anhedonia, but differences in the emotional experience task, which may also involve affective/mood general processing. These results support that anhedonia is characterized by alterations in reward processing and relies on frontal-striatal brain circuitry. The transdiagnostic approach is a promising way to reveal the overall neurobiological framework that contributes to anhedonia and could help to improve targeted treatment strategies.",
        "keywords": [
            "Activation likelihood estimation (ALE)",
            "Anhedonia",
            "Major depressive disorder",
            "Meta-analysis",
            "Schizophrenia",
            "Transdiagnostic"
        ],
        "venue": "Brain Imaging and Behavior",
        "year": 2015,
        "id": "EyPhrdEi"
    },
    "H3rJqgBu": {
        "authors": [
            {
                "name": "Xiaocui Zhang",
                "org": "Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania"
            },
            {
                "name": "Xueling Zhu",
                "org": "Medical Psychological Institute of the Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Xiang Wang",
                "org": "Medical Psychological Institute of the Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Xiongzhao Zhu",
                "org": "Medical Psychological Institute of the Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Mingtian Zhong",
                "org": "School of Psychology, South China Normal University"
            },
            {
                "name": "Jinyao Yi",
                "org": "Medical Psychological Institute of the Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Hengyi Rao",
                "org": "Department of Psychology, Sun Yat-Sen University"
            },
            {
                "name": "Shuqiao Yao",
                "org": "Medical Psychological Institute of the Second Xiangya Hospital, Central South University"
            }
        ],
        "title": "First-episode medication-naive major depressive disorder is associated with altered resting brain function in the affective network",
        "abstract": "Background: Major depressive disorder (MDD) has been associated with abnormal structure and function of the brain's affective network, including the amygdala and orbitofrontal cortex (OFC). However, it is unclear if alterations of resting-state function in this affective network are present at the initial onset of MDD. Aims: To examine resting-state function of the brain's affective network in first-episode, medication-naive patients with MDD compared to healthy controls (HCs). Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) was performed on 32 first-episode, medicationnaive young adult patients with MDD and 35 matched HCs. The amplitude of low-frequency fluctuations (ALFF) of the blood oxygen level-dependent (BOLD) signal and amygdala-seeded functional connectivity (FC) were investigated. Results: Compared to HC, MDD patients showed reduced ALFF in the bilateral OFC and increased ALFF in the bilateral temporal lobe extending to the insular and left fusiform cortices. Enhanced anti-correlation of activity between the left amygdala seed and the left OFC was found in MDD patients but not in HCs. Conclusions: Reduced ALFF in the OFC suggests hypo-functioning of emotion regulation in the affective network. Enhanced anti-correlation of activity between the amygdala and OFC may reflect dysfunction of the amygdala-OFC network and additionally represent a pathological process of MDD. \u00a9 2014 Zhang et al.",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2014,
        "id": "H3rJqgBu"
    },
    "HfR5VHtT": {
        "authors": [
            {
                "name": "Jibiao Zhang",
                "org": "Medical Psychological Institute, Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Xueling Zhu",
                "org": "Medical Psychological Institute, Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Xiang Wang",
                "org": "Medical Psychological Institute, Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Junling Gao",
                "org": "University of Hong Kong"
            },
            {
                "name": "Huqing Shi",
                "org": "Medical Psychological Institute, Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Bingsheng Huang",
                "org": "University of Hong Kong"
            },
            {
                "name": "Weijun Situ",
                "org": "Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Jinyao Yi",
                "org": "Medical Psychological Institute, Second Xiangya Hospital of Central South University"
            },
            {
                "name": "Xiongzhao Zhu",
                "org": "Key Laboratory of Psychiatry and Mental Health of Hunan Province, And Hunan Province Technology Institute of Psychiatry, Central South University"
            },
            {
                "name": "Shuqiao Yao",
                "org": "Key Laboratory of Psychiatry and Mental Health of Hunan Province, And Hunan Province Technology Institute of Psychiatry, Central South University"
            }
        ],
        "title": "Increased structural connectivity in corpus callosum in adolescent males with conduct disorder",
        "abstract": "Objective Adolescents with conduct disorder (CD) are at high risk for developing adult antisocial personality disorder. However, the underlying neuropathophysiology of CD remains poorly understood. We hypothesized that the microstructure of white matter (WM) of males with CD may differ from that of healthy control subjects (HCs). Method Tract-based spatial statistics (TBSS) and quantitative tractography were used to assess WM microstructural differences between 36 teenaged boys with CD and 33 demographically matched HCs. Results The CD group behavioral scale scores were significantly higher than those of the HCs on the Barratt Impulsivity Scale, the Strength and Difficulties Questionnaire, and the Antisocial Process Screening Device total scales. TBSS revealed that, relative to HCs, the CD group had higher fractional anisotropy (FA) in the corpus callosum (CC) region, bilaterally, including the genu and body of the CC, as well as in some projection fibers in the region of the left anterior coronal radiate and right superior coronal radiate. Tractography confirmed higher FA of fibers passing through the regions with significant differences in the TBSS results. Exploratory analysis revealed that impulsivity associated positively with the FA of these fibers in the CD group. Conclusions Maturation of WM microstructure in CD subjects differed from that in HCs, mainly in the CC. The abnormal maturation of WM structures may play an important role in the impulsivity and aggression of teenagers with CD.",
        "keywords": [
            "conduct disorder (CD)",
            "diffusion tensor imaging (DTI)",
            "impulsivity",
            "tract-based spatial statistics (TBSS)",
            "white matter (WM)"
        ],
        "venue": "Journal of the American Academy of Child and Adolescent Psychiatry",
        "year": 2014,
        "id": "HfR5VHtT"
    },
    "Ab2uvgHw": {
        "authors": [
            {
                "name": "Yunping Li",
                "org": "State Key Laboratory of Medical Genetics, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Ranran Wang",
                "org": "Department of Thoracic Surgery, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Jingqun Tang",
                "org": "Department of Thoracic Surgery, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Chen Chen",
                "org": "Department of Thoracic Surgery, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Ling Tan",
                "org": "Department of Thoracic Surgery, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Zhongshi Wu",
                "org": "Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Fenglei Yu",
                "org": "Department of Thoracic Surgery, Second Xiangya Hospital, Central South University"
            },
            {
                "name": "Xiang Wang",
                "org": "Key Laboratory of Carcinogenesis, Ministry of Health"
            }
        ],
        "title": "Progressive muscle relaxation improves anxiety and depression of pulmonary arterial hypertension patients",
        "abstract": "We explored the effects of progressive muscle relaxation (PMR) on anxiety, depression, and quality of life (QOL) in patients with pulmonary arterial hypertension (PAH). One hundred and thirty Han Chinese patients with PAH were randomly assigned to a PMR group (n = 65) and a control group (n = 65). In a 12-week study duration, the PMR group received hospital-based group and in-home PMR practice, while the control group received hospital-based mild group stretching and balance exercises. The control group and the PMR group were comparable at baseline. After 12 weeks of intervention, the PMR group showed significant improvement in anxiety, depression, overall QOL, and the mental component summary score of QOL (P < 0.05) but not the physical component summary score of QOL or the 6-minute walking distance. In contrast, the control group showed no significant improvement in any of the variables. Moreover, the PMR group showed significant improvement in all QOL mental health domains (P < 0.05) but not the physical health domains. In contrast, the control group showed no significant improvement in any QOL domain. In conclusion, this study suggests that PMR practice is effective in improving anxiety, depression, and the mental health components of QOL in patients with PAH.",
        "keywords": [
            ""
        ],
        "venue": "Evidence-based Complementary and Alternative Medicine",
        "year": 2015,
        "id": "Ab2uvgHw"
    },
    "mLNCrBt9": {
        "id": "mLNCrBt9",
        "title": "Association of the ABCG1 gene polymorphism with the susceptibility and severity of coronary atherosclerotic disease]",
        "abstract": "To investigate the association of the ATP-binding cassette sub-family G member 1 (ABCG1) gene polymorphisms with coronary atherosclerotic disease (CAD) in Chinese Han population.A population based case-control association study was carried out in 541 patients with CAD and 649 healthy controls from Chinese Han population. Two single nucleotide polymorphisms (SNPs) of the ABCG1 gene were genotyped using polymerase chain reaction-restriction fragment length polymorphism. Logistic regression was used to compare the genotypic and allelic frequency difference.The frequency of allele C of rs225374 was significantly higher in the CAD patients than that in the healthy controls (OR=1.186, 95%CI: 1.009-1.394, P=0.039), while the difference was also significant in the male subgroup (OR=1.236, 95%CI: 1.014-1.506, P=0.036). A statistically higher frequency of rs1044317 allele A was found in the CAD patients in comparison to the healthy controls (OR=1.187, 95%CI: 1.009-1.397, P=0.039). In case-only association study, rs225374 showed significant association in the high Gensini score group compared with the low Gensini score group (OR=1.303, 95%CI: 1.024-1.657, P=0.031).The two SNPs of the ABCG1 gene might be associated with the susceptibility and severity of CAD in Chinese Han population.",
        "keywords": [
            "single nucleotide polymorphism",
            "abcg1 gene",
            "coronary atherosclerotic disease",
            "association study",
            "chinese han"
        ],
        "authors": [
            {
                "name": "Long Ma",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Guanghui Cheng",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Hui Wang",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "L\u00ec L\u00ec",
                "org": "Qilu Hospital of Shandong University(Qilu Hospital of Shandong University),Jinan,China"
            },
            {
                "name": "Yaoqin Gong",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Qiji Liu",
                "org": "Shandong University(Shandong University),Jinan,China"
            }
        ],
        "venue": "Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics",
        "year": 2010
    },
    "2yK81zfs": {
        "id": "2yK81zfs",
        "title": "Association of common polymorphisms in the LRP6 gene with sporadic coronary artery disease in a Chinese population.",
        "abstract": "Genetic factors contribute to the development of coronary artery disease (CAD). Recently, a missense mutation in the low density lipoprotein receptor related protein 6 (LRP6) gene, encoding low density lipoprotein receptor related protein 6, has been implicated in an autosomal dominant form of early-onset CAD. The aim of this study was to determine whether the common variants in LRP6 are associated with sporadic CAD in Chinese.A total of 766 CAD patients and 806 healthy controls were included in this study. The presence of angiographic CAD was determined by coronary angiographic analysis. Six signal nucleotide polymorphisms (SNPs) were genotyped using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.A significant association was detected between rs11054731 in LRP6 intron 2 and CAD in our cohort (P = 0.001). The CC genotype and C allele frequency in the case group were 52% and 72%. Using a dominant model of inheritance, the C allele of rs11054731 was shown to be an independent risk factor for CAD with an OR of 1.45 (95%CI: 1.19 - 1.77, P = 0.0002). With the stratification according to the number of affected coronary arteries, an association was observed between rs11054731 and CAD (P = 0.0002). No significant association was observed between any other SNPs and the risk of CAD.The C allele of the rs11054731 within the LRP6 gene was associated with increased risk and extent of CAD in Chinese.",
        "keywords": [
            "coronary artery disease",
            "low density lipoprotein receptor related protein 6",
            "single nucleotide polymorphism"
        ],
        "authors": [
            {
                "name": "Hui Wang",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Qiji Liu",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Minzhi Chen",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Li Li",
                "org": "Qilu Hospital of Shandong University(Qilu Hospital of Shandong University),Jinan,China"
            },
            {
                "name": "Kai Zhang",
                "org": "Qilu Hospital of Shandong University(Qilu Hospital of Shandong University),Jinan,China"
            },
            {
                "name": "Guanghui Cheng",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Long Ma",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Yaoqin Gong",
                "org": "Shandong University(Shandong University),Jinan,China"
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2012
    },
    "TiOFCI0z": {
        "id": "TiOFCI0z",
        "title": "Association of rs2298212 polymorphism in OX40 gene with coronary atheroscleroticdisease in Chinese Han population",
        "abstract": "Objective: To study the association of the OX40 gene rs2298212G/A polymorphism with coronary atherosclerotic disease (CAD) in Chinese Han population. Methods: Five hundred and thirty six CAD patients and 544 age and ethnic matched controls of Chinese Han population were recruited from Qilu Hospital, Shandong University. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the selected single nucleotide polymorphism. Distributions of genotypic and allelic frequencies were analyzed by Chi-square test. Results: The distribution of genotypic and allelic frequencies have no significant differences between the CAD cases and controls ( P > 0. 05), even after adjusting for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, and triglyceride. However, when substratification analysis of the involved coronary artery vessels was performed, significant difference was found between single-vessel and triple-vessel (P = 0. 02, OR= 1. 56, 95%CI: 1. 08-12 26) involvement. Conclusion: The rs2298212G/A polymorphism in OX40 gene may be associated with the severity of coronary atherosclerotic disease.",
        "keywords": [
            "Association study",
            "Coronary atherosclerotic disease",
            "OX40 gene",
            "Single nucleotide polymorphism"
        ],
        "authors": [
            {
                "name": "Guanghui Cheng",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Hui Wang",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Long Ma",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Kai Zhang",
                "org": "Qilu Hospital of Shandong University(Qilu Hospital of Shandong University),Jinan,China"
            },
            {
                "name": "Li Li.",
                "org": "Qilu Hospital of Shandong University(Qilu Hospital of Shandong University),Jinan,China"
            },
            {
                "name": "Yaoqin Gong",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Qiji Liu",
                "org": "Shandong University(Shandong University),Jinan,China"
            }
        ],
        "venue": "Chinese Journal of Medical Genetics",
        "year": 2010
    },
    "xrnbTpEp": {
        "id": "xrnbTpEp",
        "title": "Two single nucleotide polymorphisms in <i>ALOX15</i> are associated with risk of coronary artery disease in a Chinese Han population",
        "abstract": "Arachidonate 12/15-lipoxygenase (12/15-LOX) has been implicated in the pathogenesis of atherosclerosis, but with contradicting\n results. The aim of this study was to investigate the association of two polymorphisms in ALOX15 and the risk of coronary artery disease (CAD) in a Chinese Han population. A total of 519 unrelated CAD patients and 608\n unrelated control subjects of the Chinese Han population were recruited in the case-control study. Two tagSNPs, rs7217186:T>C\n and rs2619112:G>A, were selected and genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).\n The carriers of the C allele (the CC homozygote and the CT heterozygote) of rs7217186:T>C and the carriers of the A allele\n (the AA homozygote and the GA heterozygote) of rs2619112:G>A displayed elevated odds ratios (ORs) for CAD compared with the\n TT homozygotes and GG homozygotes, respectively, after adjusting for other potential confounders including age, sex, body\n mass index, systolic blood pressure, diastolic blood pressure, glucose, triglyceride, total cholesterol, high-density lipoprotein\n cholesterol, low-density lipoprotein cholesterol, and smoking status (adjusted odds ratio [OR] = 3.2, 95% confidence interval\n [CI]: 1.335\u20137.665, P = 0.009 and adjusted OR = 3.5, 95% CI: 1.343\u20139.330, P = 0.011). In stratified analyses, after adjusting those aforementioned confounders, the CC and CT genotypes of rs7217186:T>C\n were associated with a greater risk of CAD in subjects P = 0.009) and in females (adjusted OR = 9.3, 95% CI: 1.048\u201382.213, P = 0.045). For rs2619112:G>A, subjects (<60 years) carrying the A allele had a greater risk of CAD than the GG homozygotes\n (adjusted OR = 4.9, 95% CI: 1.215\u201319.547, P = 0.025); the male carriers of A allele also had a greater risk (adjusted OR = 3.5, 95% CI: 1.136\u201311.006, P = 0.029). In summary, the present study shows that after adjustment for other confounding CAD factors, rs7217186:T>C and\n rs2619112:G>A of ALOX15 are associated with increased risk of CAD in this Chinese Han population.",
        "keywords": [
            "arachidonate 15-lipoxygenase \u00b7 single nucleo- tide polymorphism \u00b7 coronary artery disease \u00b7 chinese han population"
        ],
        "authors": [
            {
                "name": "Kai Zhang",
                "org": "Chinese Ministry of Education and Chinese Ministry of Public Health Key Laboratory of Cardiovascular Remodeling and Function Research Jinan, Shandong 250012 China"
            },
            {
                "name": "Yuan-yuan Wang",
                "org": "Chinese Ministry of Education and Chinese Ministry of Public Health Key Laboratory of Cardiovascular Remodeling and Function Research Jinan, Shandong 250012 China"
            },
            {
                "name": "Qi-ji Liu",
                "org": "Shandong University School of Medicine Laboratory for Experimental Teratology of the Ministry of Education and Institute of Medical Genetics Jinan, Shandong 250012 China"
            },
            {
                "name": "Hui Wang",
                "org": "Shandong University School of Medicine Laboratory for Experimental Teratology of the Ministry of Education and Institute of Medical Genetics Jinan, Shandong 250012 China"
            },
            {
                "name": "Fang-fang Liu",
                "org": "Chinese Ministry of Education and Chinese Ministry of Public Health Key Laboratory of Cardiovascular Remodeling and Function Research Jinan, Shandong 250012 China"
            },
            {
                "name": "Zhi-yong Ma",
                "org": "Chinese Ministry of Education and Chinese Ministry of Public Health Key Laboratory of Cardiovascular Remodeling and Function Research Jinan, Shandong 250012 China"
            },
            {
                "name": "Yao-qin Gong",
                "org": "Shandong University School of Medicine Laboratory for Experimental Teratology of the Ministry of Education and Institute of Medical Genetics Jinan, Shandong 250012 China"
            },
            {
                "name": "Li Li",
                "org": "Chinese Ministry of Education and Chinese Ministry of Public Health Key Laboratory of Cardiovascular Remodeling and Function Research Jinan, Shandong 250012 China"
            }
        ],
        "venue": "Heart and Vessels",
        "year": 2010
    },
    "Yi0rlB5E": {
        "id": "Yi0rlB5E",
        "title": "Association study between TNFSF4 and coronary heart dis-ease: Association study between TNFSF4 and coronary heart dis-ease",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "minzhi chen",
                "org": ""
            },
            {
                "name": "rongfang qiu",
                "org": ""
            },
            {
                "name": "hui wang",
                "org": ""
            },
            {
                "name": "m a long",
                "org": ""
            },
            {
                "name": "fuzhong xue",
                "org": ""
            },
            {
                "name": "qiji liu",
                "org": ""
            },
            {
                "name": "guanghui cheng",
                "org": ""
            }
        ],
        "venue": "Hereditas (beijing)",
        "year": 2011
    },
    "MS3a2cOe": {
        "id": "MS3a2cOe",
        "title": "Lack of evidence to support the association of polymorphisms within the TNFSF4 gene and coronary heart disease in a Chinese Han population.",
        "abstract": "Coronary heart disease (CHD) is a complex disorder resulting from the interaction of a number of genetic and environmental factors. Increasing evidence has shown that OX40 ligand (OX40L), also known as tumor necrosis factor superfamily member 4 (TNFSF4), plays a key role in the pathogenesis of atherosclerosis. However, there have been inconsistent reports in various populations, and further studies are required to clarify this issue. A gene-based association study was conducted using five single-nucleotide polymorphisms (SNPs) reported in previous studies. The five SNPs (rs1234314, rs45454293, rs3850641, rs1234313 and rs3861950) were genotyped in 547 unrelated CHD patients and 601 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism. rs1234314, rs3850641 and rs3861950 were further genotyped in an additional 512 cases and 520 controls using the TaqMan SNP genotyping method. A possible relationship between the five SNPs and the severity of CHD was investigated. The results revealed no significant association between the TNFSF4 polymorphism and CHD. In addition, the stratified analysis of genotypic and allelic frequencies showed no association between the TNFSF4 polymorphism and CHD in either gender. Finally, no significant correlation between the TNFSF4 polymorphism and CHD severity was detected. These findings do not support a role of the TNFSF4 gene in CHD pathogenesis in the Chinese Han population.",
        "keywords": [
            "association study",
            "coronary heart disease",
            "polymorphism",
            "tumor necrosis factor super family member 4",
            "gene",
            "apoptosis",
            "cell cycle",
            "molecular medicine",
            "cancer",
            "cell",
            "oncology"
        ],
        "authors": [
            {
                "name": "Guanghui Cheng",
                "org": "Shandong University School of Medicine(^ Shandong University School of Medicine),Jinan,China"
            },
            {
                "name": "Hui Wang",
                "org": "Shandong University School of Medicine(^ Shandong University School of Medicine),Jinan,China"
            },
            {
                "name": "Minzhi Chen",
                "org": "Shandong University School of Medicine(^ Shandong University School of Medicine),Jinan,China"
            },
            {
                "name": "L\u00ec L\u00ec",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Yaoqin Gong",
                "org": "Shandong University School of Medicine(^ Shandong University School of Medicine),Jinan,China"
            },
            {
                "name": "Qiji Liu",
                "org": "Shandong University School of Medicine(^ Shandong University School of Medicine),Jinan,China"
            }
        ],
        "venue": "Experimental and therapeutic medicine",
        "year": 2011
    },
    "noWBJDof": {
        "id": "noWBJDof",
        "title": "Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.",
        "abstract": "Arachidonate 12/15-lipoxygenase (12/15-LOX) has been implicated in the pathogenesis of atherosclerosis, but with contradicting results. The aim of this study was to investigate the association of two polymorphisms in ALOX15 and the risk of coronary artery disease (CAD) in a Chinese Han population. A total of 519 unrelated CAD patients and 608 unrelated control subjects of the Chinese Han population were recruited in the case-control study. Two tagSNPs, rs7217186:T>C and rs2619112:G>A, were selected and genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The carriers of the C allele (the CC homozygote and the CT heterozygote) of rs7217186:T>C and the carriers of the A allele (the AA homozygote and the GA heterozygote) of rs2619112:G>A displayed elevated odds ratios (ORs) for CAD compared with the TT homozygotes and GG homozygotes, respectively, after adjusting for other potential confounders including age, sex, body mass index, systolic blood pressure, diastolic blood pressure, glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and smoking status (adjusted odds ratio [OR] = 3.2, 95% confidence interval [CI]: 1.335-7.665, P = 0.009 and adjusted OR = 3.5, 95% CI: 1.343-9.330, P = 0.011). In stratified analyses, after adjusting those aforementioned confounders, the CC and CT genotypes of rs7217186:T>C were associated with a greater risk of CAD in subjects <60 years (adjusted OR = 5.7, 95% CI: 1.557-21.097, P = 0.009) and in females (adjusted OR = 9.3, 95% CI: 1.048-82.213, P = 0.045). For rs2619112:G>A, subjects (<60 years) carrying the A allele had a greater risk of CAD than the GG homozygotes (adjusted OR = 4.9, 95% CI: 1.215-19.547, P = 0.025); the male carriers of A allele also had a greater risk (adjusted OR = 3.5, 95% CI: 1.136-11.006, P = 0.029). In summary, the present study shows that after adjustment for other confounding CAD factors, rs7217186:T>C and rs2619112:G>A of ALOX15 are associated with increased risk of CAD in this Chinese Han population.",
        "keywords": [
            "arachidonate 15-lipoxygenase",
            "chinese han population",
            "coronary artery disease",
            "single nucleotide polymorphism",
            "case control study",
            "polymerase chain reaction",
            "systolic blood pressure",
            "odd ratio",
            "polymorphism",
            "adjusted odds ratio",
            "confidence interval",
            "restriction fragment length polymorphism",
            "diastolic blood pressure"
        ],
        "authors": [
            {
                "name": "Kai Zhang",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Yuanyuan Wang",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Qiji Liu",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Hui Wang",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Fangfang Liu",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Zhiyong Ma",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            },
            {
                "name": "Yaoqin Gong",
                "org": "Shandong University(Shandong University),Jinan,China"
            },
            {
                "name": "Li Li.",
                "org": "Ministry of Education China(Ministry of Education),Beijing,China"
            }
        ],
        "venue": "Heart and vessels",
        "year": 2010
    },
    "qRNQILr6": {
        "authors": [
            {
                "name": "Bo Zhao",
                "org": "Department of Gastroenterology, The Second Hospital of Qianjiang City"
            },
            {
                "name": "Xi-Zhou Zhang",
                "org": "Department of Emergency Medicine, The First People's Hospital in Yichang City"
            },
            {
                "name": "Hong Zhao",
                "org": "Department of Internal Medicine, The Second Hospital of Qianjiang City"
            },
            {
                "name": "Wei-Zhen Liu",
                "org": "Department of Internal Medicine, The Second Hospital of Qianjiang City"
            }
        ],
        "title": "Clinical significance of tissue trefoil factor 1 protein and serum pepsinogen levels in differentiation of benign and malignant gastric ulcers",
        "abstract": "AIM: To assess the clinical significance of tissue trefoil factor 1 protein and serum pepsinogen levels in the differentiation of benign and malignant gastric ulcers. METHODS: Two hundred and nineteen patients with gastric ulcer treated at the Second Hospital of Qianjiang City from October 2011 to October 2014 were included, of whom 168 had benign gastric ulcer (group A) and 51 had malignant gastric ulcer (group B). Seventy-three healthy volunteers who underwent physical examination in the same period comprised a control group. Tissue trefoil factor 1 and serum pepsinogen \u2160/\u2161 and carcinoembryonic were detected in all patients. RESULTS: The levels of tissue trefoil factor 1, serum pepsinogen \u2160 and pepsinogen \u2160/ pepsinogen \u2161 ratio were significantly lower, and serum pepsinogen \u2161 and carcinoembryonic antigen were significantly higher in group A than in the control group (P < 0.05). The levels of tissue trefoil factor 1, serum pepsinogen \u2160, and pepsinogen \u2160/pepsinogen \u2161 ratio were significantly lower, and serum pepsinogen \u2161 and carcinoembryonic antigen were significantly higher in group B than in the control group and group A (P < 0.05). Positive expression rates of tissue trefoil factor 1, serum pepsinogen \u2160, pepsinogen \u2161, pepsinogen \u2160/ pepsinogen \u2161, and carcinoembryonic antigen were significantly higher in group A than in the control group, and in group B than in the control group and group A (P < 0.05). The levels of trefoil factor 1, serum pepsinogen \u2160, and pepsinogen \u2160/pepsinogen \u2161 had a negative correlation with serum pepsinogen \u2161 and carcinoembryonic antigen. There was a positive correlation between tissue trefoil factor 1, serum pepsinogen \u2160, and pepsinogen \u2160/pepsinogen \u2161, as well as between pepsinogen \u2161 and carcinoembryonic antigen. CONCLUSION: With the occurrence and aggravation of gastric ulcer, tissue trefoil factor 1 and serum pepsinogen \u2160 increase significantly, while serum pepsinogen \u2161 decreases significantly. Trefoil factor 1 and pepsinogen can be used for differential diagnosis of benign and malignant gastric ulcers.",
        "keywords": [
            "Benign gastric ulcer",
            "Clinical significance",
            "Malignant gastric ulcer",
            "Pepsinogen",
            "Trefoil factor 1"
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2015,
        "id": "qRNQILr6"
    },
    "NfhlgHfj": {
        "id": "NfhlgHfj",
        "title": "Development of a multi-fingered massaging robot hand",
        "authors": [
            {
                "name": "Liang Han",
                "org": "Southeast University(Southeast University,Southeast Univ),Nanjing,China"
            },
            {
                "name": "Mengqian Tian",
                "org": "Southeast University(Southeast University,Southeast Univ),Nanjing,China"
            },
            {
                "name": "Jinzhong Chen",
                "org": "Southeast University(Southeast University,Southeast Univ),Nanjing,China"
            }
        ],
        "venue": "advanced materials research",
        "keywords": [
            "chinese massage",
            "multi-fingered",
            "robot hand",
            "servo motor"
        ],
        "year": 2011
    },
    "5JrcIT43": {
        "id": "5JrcIT43",
        "title": "Dynamic analysis of elbow joint in the stroke of tennis",
        "authors": [
            {
                "name": "Liang Han",
                "org": "Southeast University(Southeast University,Southeast Univ),Nanjing,China"
            },
            {
                "name": "Mengqian Tian",
                "org": "Southeast University(Southeast University,Southeast Univ),Nanjing,China"
            },
            {
                "name": "Jingliang Gui",
                "org": "Southeast University(Southeast University,Southeast Univ),Nanjing,China"
            }
        ],
        "venue": "advanced materials research",
        "keywords": [
            "a multi-rigid model",
            "dynamic analysis",
            "impact force",
            "tennis elbow"
        ],
        "year": 2011
    },
    "XMQSjagW": {
        "id": "XMQSjagW",
        "title": "The Characteristics of SK8050S and Its Experimental Exploration",
        "authors": [
            {
                "name": "Li Peng-fei",
                "org": "College of Mechanical Engineering,Southeast University,Nanjing Jiangsu ,China"
            },
            {
                "name": "Han Liang",
                "org": "College of Mechanical Engineering,Southeast University,Nanjing Jiangsu ,China"
            }
        ],
        "venue": "shanxi electronic technology",
        "keywords": [
            "L7805",
            "SK8050S",
            "regulated DC power supply",
            "switching regulator IC"
        ],
        "year": 2006
    },
    "3ONvqMEQ": {
        "id": "3ONvqMEQ",
        "title": "Experimental Study on Driving Circuit of Decoupled Vibratory Feeder",
        "authors": [
            {
                "name": "WANG Ke-yi",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "TIAN Meng-qian",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "HAN Liang",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing ,China"
            }
        ],
        "venue": "machine building & automation",
        "keywords": [
            "driving circuit",
            "decoupled",
            "vibratory feeder"
        ],
        "year": 2010
    },
    "ixXD3B48": {
        "id": "ixXD3B48",
        "title": "Design And Experimental Research of SC-01 Mechano-Electronic System Control Board",
        "authors": [
            {
                "name": "Su Rui-xin",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing Jiangsu ,China"
            },
            {
                "name": "Han Liang",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing Jiangsu ,China"
            }
        ],
        "venue": "shanxi electronic technology",
        "keywords": [
            "A/D",
            "AT89C51",
            "serial communication",
            "control board",
            "D/A"
        ],
        "year": 2007
    },
    "MtHxV5in": {
        "id": "MtHxV5in",
        "title": "Mechanical Structure Design and Experimental Study on Bowl Type Decoupled Vibratory Feeder",
        "authors": [
            {
                "name": "HAN Liang",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "LING Shaoqin",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "YAN Kaige",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing ,China"
            }
        ],
        "venue": "equipment for electronic products manufacturing",
        "keywords": [
            "Decoupled vibratory feeder",
            "Amplitude",
            "Phase difference",
            "Mechanical structure"
        ],
        "year": 2013
    },
    "5udfJgJ4": {
        "id": "5udfJgJ4",
        "title": "Principle and Experimental Study of the Acceleration Sensor ADXL105",
        "authors": [
            {
                "name": "Zhang Li",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing Jiangsu ,China"
            },
            {
                "name": "Han Liang",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing Jiangsu ,China"
            }
        ],
        "venue": "shanxi electronic technology",
        "keywords": [
            "ADXL105",
            "subtracter",
            "acceleration sensor",
            "filter"
        ],
        "year": 2007
    },
    "btmghFg1": {
        "id": "btmghFg1",
        "title": "Development of the Domestic Back-rubbing and Massaging Robot",
        "authors": [
            {
                "name": "HOU Peng",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing,China"
            },
            {
                "name": "HAN Liang",
                "org": "School of Mechanical Engineering,Southeast University,Nanjing,China"
            }
        ],
        "venue": "machine design & research",
        "keywords": [
            "ADAMS",
            "dynamic simulation",
            "cleaning and massaging robot",
            "mechanical design"
        ],
        "year": 2009
    },
    "9Rdrg7OI": {
        "id": "9Rdrg7OI",
        "title": "The Structure Design and Experimental Study of the High-speed Long-travel Electro-magnetic Driving Device",
        "authors": [
            {
                "name": "LU Xiao-long",
                "org": "College of Mechanic Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "HAN Liang",
                "org": "College of Mechanic Engineering,Southeast University,Nanjing ,China"
            }
        ],
        "venue": "equipment for electronic products manufacturing",
        "keywords": [
            "Reaction time",
            "Electro-magnet",
            "Dynamic characteristic",
            "Long-travel"
        ],
        "year": 2007
    },
    "5kLXHkLU": {
        "id": "5kLXHkLU",
        "title": "Psychological stress alters ultrastructure and energy metabolism of masticatory muscle in rats.",
        "abstract": "To investigate the effects of psychological stress on the masticatory muscles of rats, a communication box was applied to induce the psychological stress (PS) in rats. The successful establishment of psychological stimulation was confirmed by elevated serum levels of adrenocorticotropic hormone (ACTH) and changed behaviors in the elevated plusmaze apparatus. The energy metabolism of the bilateral masseter muscles was tested via chemocolorimetric analysis, whereas muscle ultrastructure was assessed by electron microscopy. In comparison to the control group, the PS group showed evidence of swollen mitochondria with cristae loss and reduced matrix density in the masticatory muscles after three weeks of stimulation; after five weeks of stimulation, severe vacuolar changes to the mitochondria were observed. Increased vascular permeability of the masticatory muscle capillaries was found in the five-week PS rats. In addition, there was decreased activity of Na(+)-K(+)ATPase and Ca(2+)-ATPase and a simultaneous increase in the activity of lactate dehydrogenase and lactic acid in the masticatory muscles of PS rats. Together, these results indicate that psychological stress induces alterations in the ultrastructure and energy metabolism of masticatory muscles in rats.",
        "keywords": [],
        "authors": [
            {
                "name": "Yongjin Chen",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Fei Huang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Min Zhang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "HaiYan Shang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            }
        ],
        "venue": "Journal of biomedicine & biotechnology",
        "year": 2010
    },
    "YgY1jVhM": {
        "id": "YgY1jVhM",
        "title": "Oxidative damage and HSP70 expression in masseter muscle induced by psychological stress in rats.",
        "abstract": "Psychological stressors are generally associated with masseter muscle dysfunction and disorders in emotional response. In addition, oxidative states and HSP70 expression, which are involved in the physical and pathological changes of the masseter muscle, could be altered in the stressed tissues and organs. However, the link between psychological stress and the redox homeostasis or the expression of HSP70 in masseter muscles in rats has not been examined. Therefore, we used a communication box paradigm to induce psychological stress in rats. The successful establishment of the animal model was evidenced by an increase in plasma corticosterone and adrenocorticotropic hormone (ACTH). Meanwhile, the stressed rats showed a decrease in the number of entries on open arms, percentage of time spent in open arms, and distance moved in the elevated plus-maze test. The stressed rats also displayed a decrease in the time spent in the center zone, active velocity, and the distance moved in the open-field test. These results demonstrate affective-like behavioral changes in the stressed rats. Moreover, compared with the control rats, a decrease in SOD, GSH-Px and catalase activities and an increase in MDA content were observed in the masseter muscles in stressed rats after 3 weeks and 5 weeks, and the HSP70 expression was elevated in muscles in the rats exposed to stress for 5 weeks. These results indicate that psychological stress induces oxidative damage and up-regulates the expression of HSP70 in masseter muscles in rats, which are associated with behavior resembling anxiety.",
        "keywords": [
            "Psychological stress",
            "Masseter muscle",
            "HSP70",
            "Oxidative stress",
            "Communication box"
        ],
        "authors": [
            {
                "name": "Qiang Li",
                "org": ""
            },
            {
                "name": "Min Zhang",
                "org": ""
            },
            {
                "name": "Yong-Jin Chen",
                "org": ""
            },
            {
                "name": "Ying-Jie Wang",
                "org": "Department of General Dentistry & Emergency, School of Stomatology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China"
            },
            {
                "name": "Fei Huang",
                "org": "Department of General Dentistry & Emergency, School of Stomatology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China"
            },
            {
                "name": "Jia Liu",
                "org": "Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China"
            }
        ],
        "venue": "Physiology & behavior",
        "year": 2011
    },
    "SguQAFRv": {
        "id": "SguQAFRv",
        "title": "Pollen and phytolith evidence for rice cultivation during the Neolithic at Longqiuzhuang, eastern Jianghuai, China",
        "abstract": "Phytolith and pollen analyses were carried out at the archaeological site at Longqiuzhuang in Gaoyou, Jiangsu, southern China. The results indicate that the key morphological phytolith types associated with cultivated rice (Oryza) are common in the Neolithic cultural layers at this site. The evidence strongly suggests that cultivated rice (mainlyO. japonica) was grown locally during the Neolithic. The archaeopalynological record provides information about the impact of human activity and, in particular, farming on the natural vegetation. The evergreen and deciduous broad-leaved forest was substantially altered, and herbaceous taxa, including ruderals, expanded. Based on the results from the phytolith and pollen analyses, two distinct phases of human activity have been recognized, namely (1) phase A (7000-6300 B.P., i.e. early Neolithic) a warm and humid period when arable farming, including rice cultivation, was pursued but the variation in the size of the carbonized rice grains was low, and (2) phase B (6300-5500 B.P., late Neolithic age), a period of relatively cold and/or arid climate when cultivated rice was of major importance and was morphologically similar to present-day rice. Environment, and in particular climate change in the late Neolithic, were important factors affecting the development of rice as a cultivated crop. It was mainly during this period that artificial selection favoured the emergence of forms similar to those of today.",
        "keywords": [
            "Phytolith analysis",
            "Pollen analysis",
            "Rice cultivation",
            "Neolithic",
            "Southern China"
        ],
        "authors": [
            {
                "name": "Fei Huang",
                "org": "Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 210008 Nanjing PR China"
            },
            {
                "name": "Min Zhang",
                "org": "Institute of Archaeology Nanjing Museum 210016 Nanjing PR China"
            }
        ],
        "venue": "Vegetation History and Archaeobotany",
        "year": 2000
    },
    "hsPm08jT": {
        "id": "hsPm08jT",
        "title": "Psychological stress induces temporary masticatory muscle mechanical sensitivity in rats",
        "abstract": "To explore the relationship between psychological stress and masticatory muscle pain, we created a communication stress animal model to determine whether psychological stress could induce increased mechanical sensitivity in masticatory muscles and to study the changes of mechanical nociceptive thresholds after stress removal. Forty-eight male Sprague-Dawley rats were divided into a control group (CON), a foot-shocked group (FS, including 3 subgroups recorded as FS-1, FS-2, and FS-3), a psychological stress group (PS), and a drug treatment group (DT). PS and DT rats were confined in a communication box for one hour a day to observe the psychological responses of neighboring FS rats. Measurements of the mechanical nociceptive thresholds of the bilateral temporal and masseter muscles showed a stimulus-response relationship between psychological stress and muscle mechanical sensitivity. The DT rats, who received a diazepam injection, showed almost the same mechanical sensitivity of the masticatory muscles to that of the control in response to psychological stress. Fourteen days after the psychological stressor was removed, the mechanical nociceptive thresholds returned to normal. These findings suggest that psychological stress is directly related to masticatory muscle pain. Removal of the stressor could be a useful method for relieving mechanical sensitivity increase induced by psychological stress. \u00a9 2011 Fei Huang et al.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Min Zhang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Fei Huang",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Yongjin Chen",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "Qiang Li",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            },
            {
                "name": "AnZhen Wu",
                "org": "The Fourth Military Medical University(Fourth Military Medical University,The Fourth Military Medical University),Xi'an,China"
            }
        ],
        "venue": "Journal of Biomedicine and Biotechnology",
        "year": 2011
    },
    "AEpthScJ": {
        "id": "AEpthScJ",
        "title": "Field Efficacy Trials of Four Normal Chemical Insectcides against Sphaerotheca fuligine",
        "abstract": "The experiment results showed the four chemical insectcides including 25% Triadimefon WP,40% Flusilazole EC,50% Kresoxim-methyl WP and 50% Sulfur SC had a good control effects against Sphaerotheca fuligine.The control effects increased as the frequency of insecicide increased and the time prolonged,especially 40% Flusilazole EC and 50% Kresoxim-methyl WP,the control effects came up to 84.21%-84.91% after 7 days of the second insectcide applied.",
        "keywords": [
            "Sphaerotheca fuligine",
            "Field efficacy trials",
            "Chemical insectcides"
        ],
        "authors": [
            {
                "name": "WANG Fang",
                "org": ""
            },
            {
                "name": "HE Xiaoli",
                "org": ""
            },
            {
                "name": "HE Yongdong",
                "org": ""
            }
        ],
        "venue": "Journal of Changjiang Vegetables",
        "year": 2010
    },
    "Uy7TAVia": {
        "id": "Uy7TAVia",
        "title": "Analysis of Germplasm Resources and Ornamental Characteristics of Primula at Juemu Valley in Tibet",
        "abstract": "This article conducts an investigation into primula at Juemu Valley in Tibet,and finds out there are6species of primula at this valley.besides,it presents the classified index of this species and summarizes the biological characteristics and habitat type of each primrose.Finally,it gives some recommendations for the application of the primroses based on their ornamental characteristics.",
        "keywords": [
            "germplasm resources",
            "ornamental characteristics",
            "primrose",
            "Tibet",
            "Juemu Valley"
        ],
        "authors": [
            {
                "name": "Wang Fang",
                "org": ""
            },
            {
                "name": "Liu Hao",
                "org": ""
            },
            {
                "name": "Xing Zhen",
                "org": ""
            }
        ],
        "venue": "Journal of Green Science and Technology",
        "year": 2013
    },
    "vSTEPQqG": {
        "id": "vSTEPQqG",
        "title": "Residues of Chlorpyrifos in Wolf berry Fruit",
        "abstract": "The studies on the final residue and dynamic degradation of 40% chlorpyrifos EC in wolfberry were carried out by GC.The results showed that the final residue was 0.225 mg/kg in wolfberry fruit at dilution of 800 in 7 days after applied two times, and the half life of chlorpyrifos in wolfberry fruit was 2.87\uff5e3.15 d.",
        "keywords": [
            "Chlorpyrifos",
            "Degradation dynamic",
            "Residues",
            "Wolfberry"
        ],
        "authors": [
            {
                "name": "ZHANG Yi",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Zong-shan",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHU Meng-meng",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            }
        ],
        "venue": "Acta Agriculturae Boreali-Occidentalis Sinica",
        "year": 2005
    },
    "8Q8pPicg": {
        "id": "8Q8pPicg",
        "title": "Residues of abamectin in wolfberry by HPLC",
        "abstract": "The studies on the final residue and dynamic degradation of 1.8% abamectin EC in wolfberry were carried out by HPLC.and the results showed that abamectin dissipated rapidly in wolfberry fruit.Spraying at 6 and 12 mg/L with an interval of 7 d,the residue was 0.008 and 0.010 mg/kg in wolfberry fruit,the half life of Abamectin in wolfberry fruit was 1.34-1.50 d.and abamectin was not defected after 7 d of last spray at dilution of 6 mg/L.Thus,this pesticide is safe when applied on wolfberry fruit at recommended rates.",
        "keywords": [
            "HPLC",
            "abamectin",
            "wolfberry",
            "residue dynamic"
        ],
        "authors": [
            {
                "name": "ZHANG Yi",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yingchuan,Ningxia ,China"
            },
            {
                "name": "ZHANG Zong-shan",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yingchuan,Ningxia ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yingchuan,Ningxia ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yingchuan,Ningxia ,China"
            }
        ],
        "venue": "Journal of Northwest Sci-Tech University of Agriculture and Forestry(Natural Science Edition)",
        "year": 2006
    },
    "B73Z0nAL": {
        "id": "B73Z0nAL",
        "title": "Inhibitory Mechanism of Biogas Slurry against Botrytis cinerea Pers.",
        "abstract": "Inhibitory mechanism of Biogas slurry was studied.The results showed that Biogas slurry had a good antimicrobial effects against Botrytis cinerea Pers..Biogas slurry suppressed spore germination strongly and affected grown of B.cinerea,which became fragmentation,switch,more spore was less significantly than CK.The results of disease index indicated that Biogas slurry made the disease process more slowly in field,but didn't have any control effects.",
        "keywords": [
            "Botrytis cinerea Pers.",
            "Inhibitory mechanism",
            "Biogas slurry"
        ],
        "authors": [
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry,Yinchuan "
            },
            {
                "name": "HE Yongdong",
                "org": "Hongsibao Development Area Agricultural Technology Center of Agriculture and Pasturage Bureau"
            },
            {
                "name": "HE Xiaoli",
                "org": "Shizuishan Grassland Service Station"
            }
        ],
        "venue": "Journal of Changjiang Vegetables",
        "year": 2010
    },
    "x7qihsFW": {
        "id": "x7qihsFW",
        "title": "Analysis of Microbial Community Function Diversity in Gravel-mulched Field",
        "abstract": "To confirm effect of mulching gravel on soil microbial community functional diversity and physical-chemical properties,the soil Biolog and physical-chemical properties were analyzed for wilderness and gravel-mulched field.The results of Biolog showed that physiological action of microbial community in 1 year gravel-mulched field was the best,others declined slowly with the increase of gravel-mulched years.The result of soil microbial community functional diversity indices showed that the effects of gravel-mulched to soil microbial community functional was indistinctive.The major carbon source used by microbial community of wilderness and gravel-mulched field had been known.The result of soil physical-chemical properties showed that all physical-chemical indices declined in 1 year gravel-mulched field.",
        "keywords": [
            "Gravel-mulched field",
            "Microbial community",
            "Biolog",
            "Functional diversity"
        ],
        "authors": [
            {
                "name": "CHEN Hong-hao",
                "org": "Institute of Plant Protection in Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection in Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Yi",
                "org": "Institute of Plant Protection in Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection in Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "GAO Li-yuan",
                "org": "Institute of Plant Protection in Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            }
        ],
        "venue": "Chinese Journal of Soil Science",
        "year": 2011
    },
    "5kMtMf9h": {
        "id": "5kMtMf9h",
        "title": "The structure and dynamics of arthropod communities in Chinese wolfberry fields under different disturbances",
        "abstract": "Through a systematic investigation of arthropod communities in Chinese wolfberry fields under different disturbances in 2008,151,628 arthropods from 4 classes,27 orders,76 families and 167 species were collected and 61 species of natural enemy sub-communities were identified. In the conventional field,organic field and abandoned field,the species numbers of the natural enemy sub-communities are 23,30 and 61 and their proportions to the total natural enemies are 10.87%,18.78%,70.34%,respectively. The individual numbers and richness in the abandoned field are significantly higher than in other fields. Evenness and diversity indices in the organic field are slightly high,while the dominant concentration in the conventional field is significantly higher. The principal component analysis on the arthropod community indicates that the drilling-leaf pest and the piercing sucking pest are the most important in different Chinese wolfberry fields. The piercing sucking pest is an obstacle for the development of organic Chinese wolfberry,while the flower-feeding and fruit-feeding pest has great damaging potential capacity and may be the dominant pest in the future. Moreover,the parasitic and pathogen natural enemies are the dominant species in the abandoned field,but the predatory natural enemies are the dominant species in organic field and the conventional field. The natural enemies play little role in the conventional field. The first pair of typical variables for natural enemies sub-communities and pest sub-communities are V1 = 0.048x1-0.2533x2+0.5951x3+0.5207x4,W1 = 0.9021y1+0.0354y2+ 0.0223y3+0.1847y4-0.0591y5,and the correlation coefficient reaches 0.8635 in the abandoned field. In the conventional and organic fields,the correlation coefficients of the first pair of typical variables reach 0.6826 and 0.7332,respectively. The growth and decline curves of pest-natural enemy communities demonstrate that the natural enemy sub-communities as a whole play a role of regulating and controlling pests. Parasitic natural enemies can greatly suppress the population of piercing sucking pest in the abandoned field,and natural enemies can also control the pest in the organic field,but natural enemies performed not well in the conventional field.",
        "keywords": [
            "Chinese wolfberry field",
            "arthropod",
            "natural enemy sub-communities",
            "community structure"
        ],
        "authors": [
            {
                "name": "ZHANG Rong",
                "org": " Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "ZHAO Zihua",
                "org": " Agriculture College,Ningxia University,Yinchuan ,China"
            },
            {
                "name": "HE Dahan",
                "org": " Agriculture College,Ningxia University,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": " Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "ZHANG Zongshan",
                "org": " Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "WANG Xinpu",
                "org": " Agriculture College,Ningxia University,Yinchuan ,China"
            }
        ],
        "venue": "Acta Ecologica Sinica",
        "year": 2010
    },
    "u7CaHMbe": {
        "id": "u7CaHMbe",
        "title": "Suitable habitat of Therioaphis trifolii population on arable lands of southern Ningxia based on GIS]",
        "abstract": "Based on GIS techniques, the interpolation maps of Therioaphis trifolii population on the arable lands in Yuanzhou District of Guyuan City in different periods were overlapped with the ecological regionalization map and digital altitude map, aimed to analyze the relations of T. trifolii population density with its ecological environment and geographical distribution. In the study area, the occurrence and distribution of T. trifolii had close relations with climate, geomorphology, and altitude. The suitable habitat of T. trifolii in the District was located in the semi-arid plain area and semi-arid holly area at the altitude 1440-2000 m, while the most possible occurrence area was the semi-arid plain at the altitude 1600-1800 m. By combining the suitable habitat with the interpolation maps of T. trifolii population in different periods, the spatial dynamics of T. trifolii population in variety of ecological areas could be analyzed quantitatively.",
        "keywords": [
            "Geographic information system",
            "Suitable habitat",
            "Therioaphis trifolii"
        ],
        "authors": [
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "MengMeng Zhu",
                "org": "Ningxia Academy of Agriculture and Forestry Sciences(Ningxia Academy of Agriculture and Forestry Sciences,Ningxia Academy of Agricultural and Forestry Sciences),Yinchuan,China"
            },
            {
                "name": "MA Jian-hua",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            }
        ],
        "venue": "Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban",
        "year": 2009
    },
    "hD24zZHA": {
        "id": "hD24zZHA",
        "title": "Compilation of Beijing Deaf People Vocation Adaptation Scale",
        "abstract": "This is the first scale of deaf people's vocation adaptation in mainland China. The scale is designed to predict the level of deaf people's vocation adaptation with the purpose of helping deaf people's employment. On the basis of other well-known scales of vocation adaptation both home and abroad, this scale proposes items in accordance with deaf people's cognition combined with Chinese culture, mental and physical characteristics of deaf people as well as the specific vocation. In addition, the scale adopts forms that can be easily understood by deaf people such as low-level reading, pictures, examples of answering questions, and brief written guidance or video model guidance. The scale has good reliability and validity through test of more than 1000 deaf people in Beijing. From the perspective of ICF, this scale not only evaluates deaf people's vocation adaptation, but also builds supportive evaluation system based on evaluation results to improve quality of deaf people's jobs.",
        "keywords": [
            "deaf people vocation adaptation scale"
        ],
        "authors": [
            {
                "name": "LIU Yanhong",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "ZHU Nan",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "LUO Wei",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "WANG Fang",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "WANG Shanfeng",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "ZHANG Shilei",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "LI Xuemei",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "TIAN He",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            },
            {
                "name": "ZHANG Yi",
                "org": "Beijing Employment Service Center for Disabled People, Beijing, "
            }
        ],
        "venue": "Chinese Journal of Special Education",
        "year": 2009
    },
    "KWWsC2NH": {
        "id": "KWWsC2NH",
        "title": "Study on predatory function of Adonia variegata on Therioaphis trifolii",
        "abstract": "The predatory function and mutual interference of adult Adonia variegata on Therioaphis trifolii,temperature and spatial heterogeneity on the predation was tested indoors.The experiment results showed that the functional response models belonged to the type of Holling \u2161.The searching efficiency decreased with the increasing prey density,and the predatory number decreased with the increase of predator density;namely,the predator individuals interfered one another.The appropriate temperature for predation was 25 \u2103.The more complex of the spatial heterogeneity,the lower predation efficiency.The theoretical expectation fit the observed values as no significant difference was observed in x2 test.",
        "keywords": [
            "Therioaphis trifolii",
            "intraspecific interference",
            "Adonia variegata",
            "spacial heterogeneity",
            "predatory functional responses"
        ],
        "authors": [
            {
                "name": "YANG Fang",
                "org": "Agricultural College of Ningxia University,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture Sciences,Yinchuan ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture Sciences,Yinchuan ,China"
            },
            {
                "name": "HE Da-han",
                "org": "Agricultural College of Ningxia University,Yinchuan ,China"
            }
        ],
        "venue": "Pratacultural Science",
        "year": 2007
    },
    "k6MvITHs": {
        "id": "k6MvITHs",
        "title": "The Dynamics of Effective Component Betaine in Lycium barbarum L. after Applying Avermectins and Pyidaben",
        "abstract": "Avermectins and pyidaben are often applied to prevent Aceria pallida and Aculops lycii in Lycium barbarum L.in Ningxia as acaricides.Betaine was extracted and the dust inside was removed by centrifugation.The content of betaine was determined by new improved colorimetry,and the dynamics of effective component betaine in Barbary Wolfberry fruit was discussed after applying avermectins and pyidaben by suggested dosage and doubling dosage.The result showed that the dynamics of betaine contents remains the same after applying avermectins and pyidaben.The doubling dosage had a significant affect,the concentration of betaine reached a peak value 3~5 days after application,then decreased to a level below normal one in 5~7 days,and got back slowly to contrast level in 7~14 days.The suggested dosages had few affect.All indicates that the dosage of avermectins and pyidaben are the main reason that influenced the betaine dynamics.The average recovery rate of betaine reclaimed by this method can reach 98.50%.",
        "keywords": [
            "dosage",
            "pyidaben",
            "recovery rate",
            "betaine",
            "avermectins"
        ],
        "authors": [
            {
                "name": "ZHAO Zi-hua",
                "org": "Agriculture College,Ningxia University,Yinchuan ;Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "HE Da-han",
                "org": "Agriculture College,Ningxia University,Yinchuan "
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            }
        ],
        "venue": "Journal of Agricultural Science and Technology",
        "year": 2008
    },
    "NMmabhAI": {
        "id": "NMmabhAI",
        "title": "Effects of Bacillus licheniformis Formulation on Soil Microorganism Community under Different Soil Conditions",
        "abstract": "Primary results on effects of Bacillus licheniformis formulation to soil microorganism community under the different soil conditions showed that Bacillus licheniformis formulation had higher colonization effect in sierozem than in irrigation-silted soil.The formulation could inhabit Fusarium oxysporum Schl.effectively,but had no effect on soil bacteria in sierozem.Whereas the formulation had no significant promoted effects on Fusarium oxysporum Schl.,but could stimulate soil bacteria in irrigation-silted soil.Under the conditions of the two types of soil,Bacillus licheniformis could also inhabit the biomass of actinobacteria.",
        "keywords": [
            "Soil types",
            "Bacillus licheniformis",
            "Soil microorganism"
        ],
        "authors": [
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "HE Yong-dong",
                "org": "Agriculture and Pasturage Bureau of Development Area in Hongsipu,Wuzhong Ningxia ,China"
            },
            {
                "name": "GAO Li-yuan",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural and Forestry Science,Yinchuan ,China"
            }
        ],
        "venue": "Acta Agriculturae Boreali-Occidentalis Sinica",
        "year": 2008
    },
    "jEo91Ckl": {
        "id": "jEo91Ckl",
        "title": "Spatial structure analysis and distribution simulation of Therioaphis trifolii population based on geostatistics and GIS]",
        "abstract": "Based on geographic information system and geostatistics, the spatial structure of Therioaphis trifolii population of different periods in Yuanzhou district of Guyuan City, the southern Ningxia Province, was analyzed. The spatial distribution of Therioaphis trifolii population was also simulated by ordinary Kriging interpretation. The results showed that Therioaphis trifolii population of different periods was correlated spatially in the study area. The semivariograms of Therioaphis trifolii could be described by exponential model, indicating an aggregated spatial arrangement. The spatial variance varied from 34.13%-48.77%, and the range varied from 8.751-12.049 km. The degree and direction of aggregation showed that the trend was increased gradually from southwest to northeast. The dynamic change of Therioaphis trifolii population in different periods could be analyzed intuitively on the simulated maps of the spatial distribution from the two aspects of time and space, The occurrence position and degree of Therioaphis trifolii to a state of certain time could be determined easily.",
        "keywords": [
            "geostatistics",
            "spatial structure",
            "simulation",
            "geographic information system",
            "therioaphis trifolii"
        ],
        "authors": [
            {
                "name": "ZHANG Rong",
                "org": "College of Agriculture,Ningxia University,Yinchuan ,China;Institute of Plant Protection,Ningxia Academy of Agricultural Sciences,Yinchuan ,China"
            },
            {
                "name": "LENG Yun-fa",
                "org": "Institute of Geographic Sciences and Natural Resources Research,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "ZHU Meng-meng",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural Sciences,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agricultural Sciences,Yinchuan ,China"
            }
        ],
        "venue": "Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban",
        "year": 2007
    },
    "dmd2anlu": {
        "id": "dmd2anlu",
        "title": "Evaluation of Low-dose Spiral CT and Multiple Planar Reconstruction in Diagnosing the Foreign Body in Trachea and Bronchi in Children",
        "abstract": "Objective To discuss the value of low-dose spiral CT and MPR in diagnosing the foreign body in trachea and bronchi in children.Materials and Methods Low dose spiral CT and MPR were performed in 51 children suspected with the foreign body in trachea and bronchi by X-ray, and compared with the results of the bronchi endoscopy.Results The sensitivity of low dose spiral CT and MPR was 100% in diagnosing the foreign body in trachea, and 95.65% in the third branches of bronchi. The results of CT were coincidence with the results of bronchi endoscopy.Conclusion Low dose spiral CT and MPR have significant clinical value in diagnosing the foreign body in trachea and bronchi in children.",
        "keywords": [
            "Low-dose Children Foreign body in trachea and bronchi Tomography",
            "X-ray computed"
        ],
        "authors": [
            {
                "name": "ZHANG Xiaofan",
                "org": ",et al. Department of CT, Harbin Children's Hospital Harbin, Heilongjiang Province , P. R. China"
            },
            {
                "name": "ZHANG Yi",
                "org": ",et al. Department of CT, Harbin Children's Hospital Harbin, Heilongjiang Province , P. R. China"
            },
            {
                "name": "WANG Fang",
                "org": ",et al. Department of CT, Harbin Children's Hospital Harbin, Heilongjiang Province , P. R. China"
            }
        ],
        "venue": "Journal of Clinical Radiology",
        "year": 2007
    },
    "L1jbQ7eu": {
        "id": "L1jbQ7eu",
        "title": "Residues of Abamectin in Wolfberry",
        "abstract": "A high performance liquid chromatography method was used to determine abamectin dissipation dynamicsand final residues in wolfberry.Applied 1.8% abamectin EC at dilution of 6 mg/L,the half life of abamectin inwolfberry fruit was 1.34 to 1.50 d,and abamectin was not detected 7 d after application.",
        "keywords": [
            "residues",
            "abamectin",
            "wolfberry",
            "dynamic degradation"
        ],
        "authors": [
            {
                "name": "ZHANG Yi",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Zong-shan",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Academy of Ningxia Agricultural and Forestry Science,Yinchuan ,China"
            }
        ],
        "venue": "Agrochemicals",
        "year": 2007
    },
    "j1fNsPTA": {
        "id": "j1fNsPTA",
        "title": "Study of Aluminum Phosphide Fumigant and Preservative of Medlar Storage",
        "abstract": "In order to kill the endangering medlar storage pest India meal moth(Plodia interpunctella),through effective dose and the least dosage of aluminium phosphide fumigant,some tests showed that 0.016 g,56% aluminium phosphide used in 25 kg medlar could kill all the larvae and eggs of the pest within seven days.The 100 of 504 double suction was used as the preservative of medlar in small packs of 0.25\u20140.5 kg.This study provided reference for improving secure production and decreasing costing.",
        "keywords": [
            "Plodia interpunctella",
            "medla",
            "storage pest",
            "preservative",
            "fumigant"
        ],
        "authors": [
            {
                "name": "Liu Hao",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "Wang Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "Zhang Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "Ma Jianhua",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Science,Yinchuan ,China"
            },
            {
                "name": "Wang Xiaojing",
                "org": "Agricultural Food and Product Quality Determination Center,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            }
        ],
        "venue": "Journal of Ningxia University(Natural Science Edition)",
        "year": 2008
    },
    "8sqcCnVJ": {
        "id": "8sqcCnVJ",
        "title": "Risk assessment and control strategies of pests in Lycium barbarum fields under different managements]",
        "abstract": "In the risk assessment of pests, both the community structure and the environmental factors should be considered at the same time, because of their mutual effects on the outbreak of disaster pests. This paper established a comprehensive assessment system, including 2 sub-systems, 5 respects, and 14 indices. In the meanwhile, risk assessment indices and experience formula were used to analyze the risk degree of pests in Lycium barbarum fields under different managements. It was found that using risk assessment indices and experience formula could obtain similar results. In abandoned field, Aceria palida, Aphis sp., and Paratrioza sinica were the frequent disaster pests, Lema decempunctata, Neoceratitis asiatica, Jaapiella sp., and Phthorimaea sp. were the incidental disaster pests, and Psylliodes obscurofaciata and Phthorimaea sp. were general pests. In organic field, the frequent disaster pests were the same species as those in abandoned field, while P. indicus, Jaapiella sp. and Phthorimaea sp. were the incidental disaster pests. In chemical control field, A. palida, Aphis sp., P. sinica, and P. indicus were the frequent disaster pests, while Jaapiella sp. and Phthorimaea sp. were the incidental disaster pests. Optimal 5 separations most fitted the division of pest sub-communities in L. barbarum fields, which were infancy period (from March 28 to April 15), outbreak I period (from April 15 to July 18), dormancy period (from July 18 to September 8), outbreak II period (from September 8 to October 15), and recession period (after October 15). The matrix of correlation coefficient showed that the dynamics of pests in L. barbarum fields under different managements were significantly correlated with each other, suggesting that the dynamics of pest populations was similar in different L. barbarum fields, which had two population establishment stages and one exponential growth stage in every year. The optimal controlling stages were from late infancy period to early and middle outbreak I periods, and from late dormancy period to early outbreak II period, which were very critical for pest control.",
        "keywords": [
            "risk assessment",
            "optimal separation",
            "control strategy.",
            "lycium barbarum",
            "disaster pests"
        ],
        "authors": [
            {
                "name": "ZHAO Zi-hua",
                "org": "College of Agronomy,Ningxia University,Yinchuan ,China;Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "ZHANG Rong",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "HE Da-han",
                "org": "College of Agronomy,Ningxia University,Yinchuan ,China"
            },
            {
                "name": "WANG Fang",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            },
            {
                "name": "ZHANG Ting-ting",
                "org": "College of Agronomy,Ningxia University,Yinchuan ,China"
            },
            {
                "name": "ZHANG Zong-shan",
                "org": "Institute of Plant Protection,Ningxia Academy of Agriculture and Forestry Sciences,Yinchuan ,China"
            }
        ],
        "venue": "Ying yong sheng tai xue bao = The journal of applied ecology / Zhongguo sheng tai xue xue hui, Zhongguo ke xue yuan Shenyang ying yong sheng tai yan jiu suo zhu ban",
        "year": 2009
    },
    "6N7A39tx": {
        "authors": [
            {
                "name": "X.X. Lin",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "Y.T. Li",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "B.C. Liu",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "F. Liu",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "F. Du",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "S.J. Wang",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "X. Lu",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "L.M. Chen",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "L. Zhang",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "X. Liu",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "J. Wang",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "F. Liu",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "X.L. Liu",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "Z.H. Wang",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "J.L. Ma",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "Z.Y. Wei",
                "org": "Beijing National Laboratory for Condensed Matter Physics"
            },
            {
                "name": "J. Zhang",
                "org": "Shanghai Jiao Tong University"
            }
        ],
        "title": "Effect of prepulse on fast electron lateral transport at the target surface irradiated by intense femtosecond laser pulses",
        "abstract": "The effects of preplasma on lateral fast electron transport at front target surface, irradiated by ultraintense (> 1018 W/cm2) laser pulses, are investigated by K\u03b1 imaging technique. A large annular K\u03b1 halo with a diameter of \u223c560\u03bcm surrounding a central spot is observed. A specially designed steplike target is used to identify the possible mechanisms. It is believed that the halos are mainly generated by the lateral diffusion of fast electrons due to the electrostatic and magnetic fields in the preplasma. This is illustrated by simulated electron trajectories using a numerical model. \u00a9 2010 The American Physical Society.",
        "keywords": [
            ""
        ],
        "venue": "Physical Review E - Statistical, Nonlinear, and Soft Matter Physics",
        "year": 2010,
        "id": "6N7A39tx"
    },
    "hz6sDSB9": {
        "authors": [
            {
                "name": "G. Kuang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "J. Shan",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "W. Xu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Q. Zhang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Y. Liu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "D. Liu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "F. Liu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "J. Lin",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "G. Zheng",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "J. Wu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "W. Zhu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "B. Ding",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "L. Shang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "H. Xu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "C. Yang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Y. Zhou",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Y. Fang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "J. Xie",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Y. Wan",
                "org": "Chinese Academy of Sciences"
            }
        ],
        "title": "Lower hybrid current drive system on the superconductive tokamak HT-7",
        "abstract": "A lower hybrid current drive system has been built for the HT-7 superconductive tokamak to deliver a 1.2-MW microwave at a frequency of 2.45 GHz for a pulse length of up to 5 s. Twelve klystron amplifiers are used as wave generators, each generating a 100-kW (130 kW at maximum) microwave. A grill coupler composed of 2 \u00d7 12 waveguides is used to launch the waves from the 12 klystrons. The wave phase difference between the adjacent waveguides in either row of the grill can be set at any desired value by feedback controlling the digital phase shifters in the low-power microwave circuits in front of the klystrons. The 12 klystrons are fed by two equal high-voltage power supplies. The technical reliability of the system is shown by experimental results.",
        "keywords": [
            ""
        ],
        "venue": "Fusion Technology",
        "year": 1999,
        "id": "hz6sDSB9"
    },
    "udluHOvu": {
        "authors": [
            {
                "name": "L. Volpe",
                "org": "University of Bordeaux"
            },
            {
                "name": "D. Batani",
                "org": "University of Bordeaux"
            },
            {
                "name": "G. Birindelli",
                "org": "University of Milano-Bicocca"
            },
            {
                "name": "A. Morace",
                "org": "University of Milano-Bicocca"
            },
            {
                "name": "P. Carpeggiani",
                "org": "University of Milano-Bicocca"
            },
            {
                "name": "M.H. Xu",
                "org": "Institute of Physics"
            },
            {
                "name": "F. Liu",
                "org": "Institute of Physics"
            },
            {
                "name": "Y. Zhang",
                "org": "Institute of Physics"
            },
            {
                "name": "Z. Zhang",
                "org": "Institute of Physics"
            },
            {
                "name": "X.X. Lin",
                "org": "Institute of Physics"
            },
            {
                "name": "F. Liu",
                "org": "Institute of Physics"
            },
            {
                "name": "S.J. Wang",
                "org": "Institute of Physics"
            },
            {
                "name": "P.F. Zhu",
                "org": "Institute of Physics"
            },
            {
                "name": "L.M. Meng",
                "org": "Institute of Physics"
            },
            {
                "name": "Z.H. Wang",
                "org": "Institute of Physics"
            },
            {
                "name": "Y.T. Li",
                "org": "Institute of Physics"
            },
            {
                "name": "Z.M. Sheng",
                "org": "Institute of Physics"
            },
            {
                "name": "Z.Y. Wei",
                "org": "Institute of Physics"
            },
            {
                "name": "J. Zhang",
                "org": "Institute of Physics"
            },
            {
                "name": "J.J. Santos",
                "org": "University of Bordeaux"
            },
            {
                "name": "C. Spindloe",
                "org": "Rutherford Appleton Laboratory"
            }
        ],
        "title": "Propagation of a short-pulse laser-driven electron beam in matter",
        "abstract": "We studied the transport of an intense electron beam produced by high intensity laser pulses through metals and insulators. Targets were irradiated at two different intensities, 10",
        "keywords": [
            ""
        ],
        "venue": "Physics of Plasmas",
        "year": 2013,
        "id": "udluHOvu"
    },
    "8cvLPWUE": {
        "authors": [
            {
                "name": "Y.T. Li",
                "org": ""
            },
            {
                "name": "X.X. Lin",
                "org": ""
            },
            {
                "name": "F. Liu",
                "org": ""
            },
            {
                "name": "B.C. Liu",
                "org": ""
            },
            {
                "name": "F. Du",
                "org": ""
            },
            {
                "name": "S.J. Wang",
                "org": ""
            },
            {
                "name": "C. Li",
                "org": ""
            },
            {
                "name": "M.L. Zhou",
                "org": ""
            },
            {
                "name": "L. Zhang",
                "org": ""
            },
            {
                "name": "X. Liu",
                "org": ""
            },
            {
                "name": "J. Wang",
                "org": ""
            },
            {
                "name": "F. Liu",
                "org": ""
            },
            {
                "name": "X.L. Liu",
                "org": ""
            },
            {
                "name": "L.M. Chen",
                "org": ""
            },
            {
                "name": "Z.H. Wang",
                "org": ""
            },
            {
                "name": "J.L. Ma",
                "org": ""
            },
            {
                "name": "Z.Y. Wei",
                "org": ""
            },
            {
                "name": "J. Zhang",
                "org": ""
            }
        ],
        "title": "Lateral propagation of fast electrons at the laser-irradiated target surfaces",
        "abstract": "Lateral propagation of fast electrons at the target surfaces irradiated by femtosecond intense laser pulses is measured by k",
        "keywords": [
            ""
        ],
        "venue": "Journal of Physics: Conference Series",
        "year": 2010,
        "id": "8cvLPWUE"
    },
    "dZOaJLAp": {
        "authors": [
            {
                "name": "Hong Li",
                "org": "Research Center of Fluid Machinery Engineering and Technology, Jiangsu University"
            },
            {
                "name": "Bo Jiang",
                "org": "Research Center of Fluid Machinery Engineering and Technology, Jiangsu University"
            },
            {
                "name": "Tianqiao Lu",
                "org": "Research Center of Fluid Machinery Engineering and Technology, Jiangsu University"
            }
        ],
        "title": "Visualization experiment of gas-liquid two-phase flow of pump during self-priming process",
        "abstract": "The transient self-priming process is characterized by a complex gas-liquid two-phase flow in the pump, and the gas-liquid mixture and separation effects play a crucial role in gas exhaustion, which further affect the self-priming performance. The collaboration system between the external characteristic of self-priming performance and gas-liquid two-phase flow characteristic during self-priming process was built. Then the experimental instant pump inlet and outlet pressure, pump inlet and outlet flow rate, rotational speed were obtained and programmed by the LabVIEW software. Gas-liquid two-phase flow phenomena in the impeller, volute and gas-liquid separation chamber was observed by high-speed photography system. Results showed that the self-priming process was stable under dynamic conditions before liquid flow was increased. The stable gas-liquid separation interface which appeared at the outlet of the diffuser contributed to gas-liquid separation and gas exhaustion. Bubbles which convoluted at the outlet of the diffuser were not conducive to gas exhaustion in time. During the start-up process, the gas-liquid velocity and the number of bubbles at each section of the volute were in the oscillatory process due to the unstable pressure differential in the impeller. At last instant self-priming process, there was a sudden change in flow rate and pressure. Drops in the gas-liquid separation chamber and bubbles in the diffuser were increased sharply, and then decreased rapidly. The results testified the transient effect during the last instant self-priming process. Microscopic variations of gas-liquid two-phase flow are consistent with macroscopic variations of pressure, flow rate and rotational speed measured by experimental instruments.",
        "keywords": [
            "Dynamic test",
            "Gas-liquid two-phase flow",
            "Pump",
            "Self-priming process",
            "Visualization"
        ],
        "venue": "Nongye Jixie Xuebao/Transactions of the Chinese Society for Agricultural Machinery",
        "year": 2015,
        "id": "dZOaJLAp"
    },
    "WA8unUqC": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": ""
            },
            {
                "name": "Yongwei Sun",
                "org": ""
            },
            {
                "name": "Rui Zhang",
                "org": ""
            },
            {
                "name": "Shaoliang Bai",
                "org": ""
            }
        ],
        "title": "Study on the moment amplification measures of column ends based on the beam sidesway mechanism",
        "keywords": [
            "Moment amplification factor of column end",
            "Moment-resisting frame",
            "Nonlinear analysis",
            "Reinforced concrete",
            "Strong column and weak beam"
        ],
        "venue": "Tumu Gongcheng Xuebao/China Civil Engineering Journal",
        "year": 2014,
        "id": "WA8unUqC"
    },
    "UkFfwHCT": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Lab. of Education Ministry of New Technol. for Construction of Cities in Mountain Area"
            },
            {
                "name": "He-Ping Zhang",
                "org": "College of Civil Eng."
            },
            {
                "name": "Wen-Jin Luo",
                "org": "Vocational College of Architecture Eng."
            },
            {
                "name": "Shao-Liang Bai",
                "org": "Key Lab. of Education Ministry of New Technol. for Construction of Cities in Mountain Area"
            }
        ],
        "title": "Rational value of moment amplification measures at column ends in RC frames under bi-directional horizontal seismic action",
        "keywords": [
            "3D frame",
            "Bi-directional horizontal seismic action",
            "Nonlinear analysis",
            "Reinforced concrete",
            "Strong column-weak beam"
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2012,
        "id": "UkFfwHCT"
    },
    "PhURcS5E": {
        "authors": [
            {
                "name": "Yong Liao",
                "org": "Key Laboratory of Aerocraft Tracking Telemetering and Command and Communication"
            },
            {
                "name": "Shi-Zhong Yang",
                "org": "Key Laboratory of Aerocraft Tracking Telemetering and Command and Communication"
            },
            {
                "name": "Hong Yang",
                "org": "Key Laboratory of Aerocraft Tracking Telemetering and Command and Communication"
            },
            {
                "name": "Hai-Bo Wei",
                "org": "Key Laboratory of Aerocraft Tracking Telemetering and Command and Communication"
            }
        ],
        "title": "Optimal quantum reception of multidimensional orthogonal envelope signal with background noise",
        "keywords": [
            "Free space optical communication",
            "Quantum communication",
            "Quantum detection theory",
            "Signal detection"
        ],
        "venue": "Beijing Youdian Daxue Xuebao/Journal of Beijing University of Posts and Telecommunications",
        "year": 2012,
        "id": "PhURcS5E"
    },
    "bPN28tJQ": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Lab. of Ministry of Education for New Technol. and Construction of Cities in Mountain Area"
            },
            {
                "name": "Jing-Ke Chen",
                "org": "School of Civil Eng."
            },
            {
                "name": "Yin-Song Chen",
                "org": "Wuhan Architectural Design Inst."
            }
        ],
        "title": "Effects of infill walls on nonlinear seismic response characteristics of spatial frames",
        "keywords": [
            "Infill wall",
            "Irregular configuration",
            "Nonlinear analysis",
            "Reinforced concrete",
            "Spatial frame"
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2012,
        "id": "bPN28tJQ"
    },
    "Mk1FW8JQ": {
        "authors": [
            {
                "name": "Jianping Fu",
                "org": "Key Lab. of New Technol. Construction of Cities in Mountain Area of China Ministry of Education, Chongqing University"
            },
            {
                "name": "Hong Yang",
                "org": "Key Lab. of New Technol. Construction of Cities in Mountain Area of China Ministry of Education, Chongqing University"
            },
            {
                "name": "Qiang Huang",
                "org": ""
            },
            {
                "name": "Feng Xue",
                "org": "Key Lab. of New Technol. Construction of Cities in Mountain Area of China Ministry of Education, Chongqing University"
            }
        ],
        "title": "Nonlinear dynamic response of frame structures reinforced with high strength steel bars under strong earthquake action",
        "keywords": [
            "Displacement ductility factor",
            "High strength steel bar",
            "Nonlinear dynamic response",
            "RC frame",
            "Strong earthquake action",
            "Ultimate drift angle"
        ],
        "venue": "Jianzhu Jiegou Xuebao/Journal of Building Structures",
        "year": 2014,
        "id": "Mk1FW8JQ"
    },
    "1Y6ARied": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "Key Laboratory of Manufacturing Industrial Integrated Automation"
            },
            {
                "name": "Xiaowei Han",
                "org": "Key Laboratory of Manufacturing Industrial Integrated Automation"
            },
            {
                "name": "Hong Yang",
                "org": "Key Laboratory of Manufacturing Industrial Integrated Automation"
            },
            {
                "name": "Binbin Hao",
                "org": "School of Information Science and Engineering"
            }
        ],
        "title": "On global adaptive synchronization in weighted complex networks",
        "keywords": [
            "Lyapunov stability theory",
            "pinning control",
            "synchronization",
            "weighted network"
        ],
        "venue": "Computer Journal",
        "year": 2012,
        "id": "1Y6ARied"
    },
    "YtYzH3xJ": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Lab. of Ministry of Education of New Technol. for Construction of Cities in Mountain Area"
            },
            {
                "name": "Rui Zhang",
                "org": "College of Civil Eng."
            },
            {
                "name": "Deng-Ke Zang",
                "org": "Chongqing Architecture Design Inst."
            },
            {
                "name": "De-Sheng Dou",
                "org": "College of Civil Eng."
            }
        ],
        "title": "Fiber model based nonlinear shear effect modeling method and its calibration",
        "keywords": [
            "Fiber model",
            "Nonlinear analysis",
            "Reinforced concrete",
            "Shear deformation",
            "Shear walls"
        ],
        "venue": "Sichuan Daxue Xuebao (Gongcheng Kexue Ban)/Journal of Sichuan University (Engineering Science Edition)",
        "year": 2011,
        "id": "YtYzH3xJ"
    },
    "gnkMpCgA": {
        "authors": [
            {
                "name": "Qiukuan Wang",
                "org": "Key Laboratory of Advanced Manufacturing Technology for Automobile Parts, Ministry of Education, Chongqing University of Technology"
            },
            {
                "name": "Hong Yang",
                "org": "Key Laboratory of Advanced Manufacturing Technology for Automobile Parts, Ministry of Education, Chongqing University of Technology"
            },
            {
                "name": "Guangyong Li",
                "org": "Key Laboratory of Advanced Manufacturing Technology for Automobile Parts, Ministry of Education, Chongqing University of Technology"
            },
            {
                "name": "Yan Yang",
                "org": "Key Laboratory of Advanced Manufacturing Technology for Automobile Parts, Ministry of Education, Chongqing University of Technology"
            }
        ],
        "title": "Three-dimensional visualization of the micro-structure and mechanism of magnetorheological fluids using digital micro-holography",
        "keywords": [
            "Holography",
            "Magneto rheological fluids",
            "Micro-structure",
            "Responding time",
            "Three-dimensional visualization"
        ],
        "venue": "Zhongguo Jiguang/Chinese Journal of Lasers",
        "year": 2014,
        "id": "gnkMpCgA"
    },
    "01Z8a9lr": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Laboratory of New Technology for Construction of Cities in Mountain Area(Chongqing University), Ministry of Education"
            },
            {
                "name": "Wen-Tong Zhao",
                "org": "College of Civil Engineering, Chongqing Univ"
            },
            {
                "name": "Lin-Hui Mo",
                "org": "China Machinery International Engineering Design and Research Institute Co Ltd"
            },
            {
                "name": "Bo Li",
                "org": "College of Civil Engineering, Chongqing Univ"
            }
        ],
        "title": "Seismic response analysis of RC frame considering inelastic deformations of beam-column joints",
        "keywords": [
            "Frame structure",
            "Joint",
            "Longitudinal bar slippage",
            "Reinforced concrete",
            "Shear deformation"
        ],
        "venue": "Hunan Daxue Xuebao/Journal of Hunan University Natural Sciences",
        "year": 2014,
        "id": "01Z8a9lr"
    },
    "3pcIkUIu": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Laboratory of New Technology for Construction of Cities in Mountain Area of the Ministry of Education, Chongqing University"
            },
            {
                "name": "Qin Xie",
                "org": "School of Civil Engineering, Chongqing University"
            },
            {
                "name": "Jiqing Zhang",
                "org": "Chongqing Municipal Engineering Design Institute"
            },
            {
                "name": "Jianping Fu",
                "org": "Key Laboratory of New Technology for Construction of Cities in Mountain Area of the Ministry of Education, Chongqing University"
            }
        ],
        "title": "A modified constitutive model of reinforcing bars considering buckling effects and its experimental verification",
        "keywords": [
            "Buckling",
            "Constitutive model",
            "Nonlinear analysis",
            "Reinforced concrete",
            "Reinforcing steel bars"
        ],
        "venue": "Tumu Gongcheng Xuebao/China Civil Engineering Journal",
        "year": 2015,
        "id": "3pcIkUIu"
    },
    "AzPPdWZF": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Laboratory of New Technology for Construction of Cities in Mountain Area"
            },
            {
                "name": "Zhenhua Zhu",
                "org": "Chongqing University"
            },
            {
                "name": "Shaoliang Bai",
                "org": "Key Laboratory of New Technology for Construction of Cities in Mountain Area"
            }
        ],
        "title": "An evaluation of the effectiveness of the Chinese strong column weak beam measure under bi-directional horizontal seismic excitations",
        "keywords": [
            "3-D frame",
            "Bi-directional horizontal seismic",
            "Nonlinear analysis",
            "Reinforced concrete",
            "Strong column-weak beam"
        ],
        "venue": "Tumu Gongcheng Xuebao/China Civil Engineering Journal",
        "year": 2011,
        "id": "AzPPdWZF"
    },
    "4rLVcdVE": {
        "authors": [
            {
                "name": "Hong Yang",
                "org": "Key Lab. of New Technol. for Construction of Cities in Mountain Area of China Ministry of Education, Chongqing University"
            },
            {
                "name": "Linhui Mo",
                "org": "China Machinery International Engineering Design and Research Institute Co., Ltd"
            },
            {
                "name": "Jinke Chen",
                "org": "College of Civil Engineering, Chongqing University"
            },
            {
                "name": "Jianping Fu",
                "org": "Key Lab. of New Technol. for Construction of Cities in Mountain Area of China Ministry of Education, Chongqing University"
            }
        ],
        "title": "Study on modified models for inelastic deformation of reinforced concrete beam-column joints",
        "keywords": [
            "Constitutive model",
            "Inelastic deformation",
            "Nonlinear fitting",
            "Reinforced concrete beam-column joint"
        ],
        "venue": "Jianzhu Jiegou Xuebao/Journal of Building Structures",
        "year": 2014,
        "id": "4rLVcdVE"
    },
    "mYL3aaUY": {
        "authors": [
            {
                "name": "Lili Gao",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Zheng Zhang",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Weizhen Wang",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Xiangyu Hou",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Jing Wang",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Xiang Gao",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Chong Chen",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Zhendong Cui",
                "org": "Institute of Seawater Desalination and Multipurpose Utilization"
            }
        ],
        "title": "A green pre-film for carbon steel by cerium salt in seawater",
        "abstract": "An environment-friendly pre-film for carbon steel was obtained by using seawater with cerium salt. The influencing factors of cerium salt pre-film were discussed through orthogonal experiments, and the optimum processing parameters were confirmed. Then morphology, composition, the forming process and corrosion resistance of the pre-film were investigated. Analysis by digital microscope showed that the cerium salt pre-film was a blue uniform coating. EDS images displayed that the pre-film consisted of Ce, O and Fe, the major component of the protective layer was a mixture of Ce oxide, Ce hydroxide and Fe hydroxide. The results of electrochemical potentiodynamic polarization and gravimetric measurements indicated that the cerium salt pre-film provided effective protection to the substrate of carbon steel. \u00a9 (2012) Trans Tech Publications, Switzerland.",
        "keywords": [
            "Carbon steel",
            "Cerium salt",
            "Pre-film",
            "Seawater"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "mYL3aaUY"
    },
    "YDO0BJxv": {
        "authors": [
            {
                "name": "Xiang Yu Hou",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Chun Yang Hou",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Zheng Zhang",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Wei Zhen Wang",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Li Li Gao",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Jing Wang",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Xiang Gao",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            },
            {
                "name": "Zhen Dong Cui",
                "org": "The Institute of Seawater Desalination and Multipurpose Utilization"
            }
        ],
        "title": "Synthesis and characters of Fe 3O 4/AMPS magnetic composite material",
        "abstract": "The synthesis of Fe ",
        "keywords": [
            "Core-shell",
            "Fe3O4/AMPS",
            "Magnetic composite material",
            "Superparamagnetic"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "YDO0BJxv"
    },
    "4JJJOdIl": {
        "id": "4JJJOdIl",
        "title": "Mucormycosis in a patient with renal failure:case report and review of literatures",
        "authors": [
            {
                "name": "YE Wen-ling",
                "org": "Dept. of Nephrology"
            },
            {
                "name": "WANG Peng",
                "org": "Clinical Lab"
            },
            {
                "name": "WANG Ying-yi",
                "org": "Dept. of Medicine,PUMC Hospital,PUMC & CAMS,Beijing ,China"
            },
            {
                "name": "ZHANG Yao",
                "org": "Dept. of Medicine,PUMC Hospital,PUMC & CAMS,Beijing ,China"
            },
            {
                "name": "YU Yang",
                "org": "Dept. of Nephrology"
            },
            {
                "name": "LI Hang",
                "org": "Dept. of Nephrology"
            },
            {
                "name": "LI Xue-mei",
                "org": "Dept. of Nephrology"
            }
        ],
        "venue": "basic & clinical medicine",
        "keywords": [
            "amphotericin B",
            "chronic renal failure",
            "mucormycosis"
        ],
        "year": 2009
    },
    "yzRrsmHn": {
        "id": "yzRrsmHn",
        "title": "A low dose of rapamycin ameliorates renal injuries of type 2 diabetic mice",
        "authors": [
            {
                "name": "WANG De-guang",
                "org": ",et al.Division of Nephrology,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": ",et al.Division of Nephrology,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LI hang",
                "org": ",et al.Division of Nephrology,Peking Union Medical College Hospital,Chinese Academy of Medical Science & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "chinese journal of diabetes",
        "keywords": [
            "Vascular endothelial growth factor",
            "Diabetes mellitus",
            "Diabetic nephropathy",
            "type 2",
            "Rapamycin"
        ],
        "year": 2010
    },
    "osgpMPE9": {
        "id": "osgpMPE9",
        "title": "Effect of low-flux polysulphone membranes on the serum levels of inflammatory cytokines, C-reactive protein, lipoprotein (a), and beta2 microglobulin in hemodialysis patients]",
        "authors": [
            {
                "name": "Tao Jian-Ling",
                "org": "Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China."
            },
            {
                "name": "Sun Yang"
            },
            {
                "name": "Li Xue-Mei"
            },
            {
                "name": "Li Hang"
            },
            {
                "name": "Wang Yu-Ying"
            },
            {
                "name": "Li Xue-Wang"
            }
        ],
        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [],
        "year": 2009
    },
    "IKZ7qQqj": {
        "id": "IKZ7qQqj",
        "title": "Non-traumatic rhabdomyolysis:clinical analysis of thirty-nine cases.",
        "authors": [
            {
                "name": "CAI Jian-fang",
                "org": ".PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "QU Xuan",
                "org": ".PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": ".PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LIU Zheng-yin",
                "org": ".PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": ".PUMC Hospital,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "chinese journal of practical internal medicine",
        "keywords": [
            "rhabdomyolysis",
            "acute renal failure",
            "compartmental syndrome"
        ],
        "year": 2008
    },
    "wQzkcJv1": {
        "id": "wQzkcJv1",
        "title": "Effects of Rosiglitazone on the Expression Connective Tissue Growth Factor in Tubulointerstitium in KKA~y Mice",
        "authors": [
            {
                "name": "QIN Yan",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "WEN Yu-bing",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "CHEN Li-meng",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "DUAN Lin",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Yan",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "acta academiae medicinae sinicae",
        "keywords": [
            "diabetic mice",
            "connective tissue growth factor",
            "tubulointerstitium",
            "rosiglitazone",
            "peroxisome proliferator activated receptor-\u03b3"
        ],
        "year": 2006
    },
    "OgtycBaN": {
        "id": "OgtycBaN",
        "title": "Insulin stimulates vascular endothelial growth factor gene expression in mesangial cells through a phosphotidylinositol-3 kinase/mammalian target of rapamycin-dependent signaling pathway",
        "authors": [
            {
                "name": "WANG De-guang",
                "org": "ivision of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing , China"
            },
            {
                "name": "LI Xue-wang",
                "org": "ivision of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing , China"
            },
            {
                "name": "LI Hang",
                "org": "ivision of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing , China"
            },
            {
                "name": "l. D",
                "org": "ivision of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing , China"
            }
        ],
        "venue": "chinese journal of diabetes",
        "keywords": [
            "Vascular endothelial growth factor",
            "Phosphatidylinositol-3-kinase/mammalian target of rapamycin",
            "Hypoxiainducible factor-1",
            "Insulin"
        ],
        "year": 2009
    },
    "OBS9SXmM": {
        "id": "OBS9SXmM",
        "title": "Application of rapamycin to the treatment for chronic kidney diseases",
        "authors": [
            {
                "name": "ZHANG Guo-juan"
            },
            {
                "name": "LI Hang"
            },
            {
                "name": "LI Xue-wang"
            }
        ],
        "venue": "chinese journal of practical internal medicine",
        "keywords": [
            "rapamycin",
            "chronic kidney disease"
        ],
        "year": 2008
    },
    "33R25Bst": {
        "id": "33R25Bst",
        "title": "Study on the way of repairing defects of nose by bilobe flaps",
        "authors": [
            {
                "name": "LI Hang",
                "org": "Department of Dermatology,First Hospital of Peking University,Beijing ,China"
            },
            {
                "name": "ZHANG Zi-jun",
                "org": "Department of Dermatology,First Hospital of Peking University,Beijing ,China"
            },
            {
                "name": "YANG Shu-xia",
                "org": "Department of Dermatology,First Hospital of Peking University,Beijing ,China"
            }
        ],
        "venue": "practical journal of clinical medicine",
        "keywords": [
            "Cutaneous deficiency",
            "Bilobed skin flap",
            "Nose tumor",
            "Repair"
        ],
        "year": 2009
    },
    "NfNcfot9": {
        "id": "NfNcfot9",
        "title": "Effect of simvastatin on PMA-induced expression of type A scavenger receptor in human glomerular mesangial cells",
        "authors": [
            {
                "name": "YE Wen-ling",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            },
            {
                "name": "LI Xue-wang",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            },
            {
                "name": "XU Cai-min",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            },
            {
                "name": "LI Hang",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            },
            {
                "name": "LI Yan",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            },
            {
                "name": "DUAN Lin",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            },
            {
                "name": "JIN Jing",
                "org": ". Division of Nephrology, Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing , China"
            }
        ],
        "venue": "chinese journal of nephrology",
        "keywords": [
            "Glomerulonephritis",
            "Fhorbol esters",
            "Simvastatin",
            "Type A scavenger receptor",
            "Mesangial cells"
        ],
        "year": 2006
    },
    "2VU95wdk": {
        "id": "2VU95wdk",
        "title": "Effects of very low-density lipoprotein on cellular lipid accumulation and the expression of monocyte chemoattractant protein-1 in human mesangial cells]",
        "authors": [
            {
                "name": "LI Jing",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "WEN Yu-bing",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [
            "monocyte chemoattractant protein-1",
            "very low-density lipoprotein",
            "mesangial cell",
            "glomerular sclerosis"
        ],
        "year": 2009
    },
    "4NlgGCHZ": {
        "id": "4NlgGCHZ",
        "title": "Effects of rosiglitazone on the expression connective tissue growth factor in tubulointerstitium in KKA(y) mice]",
        "authors": [
            {
                "name": "Qin Yan",
                "org": "Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China."
            },
            {
                "name": "Li Xue-wang"
            },
            {
                "name": "Wen Yu-bing"
            },
            {
                "name": "Li Hang"
            },
            {
                "name": "Chen Li-meng"
            },
            {
                "name": "Duan Lin"
            },
            {
                "name": "Li Yan"
            }
        ],
        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [],
        "year": 2006
    },
    "7TxMd9Bt": {
        "id": "7TxMd9Bt",
        "title": "Expression of cyclooxygenase-2 in a mouse macula densa cell lines and signal transduction of NF-kappaB and AP-1]",
        "authors": [
            {
                "name": "Liu Dong-Yan",
                "org": "Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China."
            },
            {
                "name": "Li Xue-Wang"
            },
            {
                "name": "Li Hang"
            },
            {
                "name": "Li Xue-Mei"
            },
            {
                "name": "Ye Weng-Ling"
            }
        ],
        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [],
        "year": 2007
    },
    "g9fqhQ7C": {
        "id": "g9fqhQ7C",
        "title": "Low salt induces the expression of cyclooxygenase-2 in a mouse macula densa cells through the activation of ERK\u3001AP-1 pathways",
        "authors": [
            {
                "name": "LIU Dong-yan",
                "org": "Div. Nephrology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing , China"
            },
            {
                "name": "LI Xue-wang",
                "org": "Div. Nephrology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing , China"
            },
            {
                "name": "LI Hang",
                "org": "Div. Nephrology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing , China"
            },
            {
                "name": "LI Xue-mei",
                "org": "Div. Nephrology,Peking Union Medical College Hospital,CAMS & PUMC,Beijing , China"
            }
        ],
        "venue": "basic & clinical medicine",
        "keywords": [
            "cyclooxygenase-2",
            "plasmid",
            "AP-1",
            "p44/p42 kinase",
            "PGE2"
        ],
        "year": 2007
    },
    "airhXrsQ": {
        "id": "airhXrsQ",
        "title": "Clinical and pathologic characteristic analysis of minimal change diseases of mesangial IgA deposition",
        "authors": [
            {
                "name": "LI Hang",
                "org": "Department of Nephrology, Peking Union Medical College Hospital, Beijing "
            },
            {
                "name": "WEN Yu-bing",
                "org": "Department of Nephrology, Peking Union Medical College Hospital, Beijing "
            },
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                "name": "LI Xue-wang",
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        "keywords": [
            "Minimal change disease IgA mesangial deposition IgA nephropathy"
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    },
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        "title": "Transitional cell carcinoma in patients with chronic renal failure",
        "authors": [
            {
                "name": "CAI Jian-fang",
                "org": "Department of Peking Union Medical College Hospital, Beijing "
            },
            {
                "name": "WANG Jing",
                "org": "Department of Peking Union Medical College Hospital, Beijing "
            },
            {
                "name": "LI Hang",
                "org": "Department of Peking Union Medical College Hospital, Beijing "
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        "venue": "beijing medical journal",
        "keywords": [
            "Transitional cell carcinoma(TCC) Chronic renal failure(CRF)"
        ],
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    },
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        "title": "Effects of rapamycin on cholesterol homeostasis and secretory function of 3T3-L1 cells]",
        "authors": [
            {
                "name": "LI Jin-hong",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LIU Ying-jiu",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "ZHANG Guo-juan",
                "org": "Department of Nephrology,Beijing Tongren Hospital,Beijing ,China"
            },
            {
                "name": "YIN Hong-chao",
                "org": "Department of Pathology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
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                "name": "TAO Jian-ling",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [
            "3t3-l1 cells",
            "Cholesterol",
            "Leptin",
            "Peroxisome proliferator-activated receptor \u03b3",
            "Rapamycin"
        ],
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        "id": "XEOxkR9R",
        "title": "Non-diabetic renal disease in type II diabetes mellitus]",
        "authors": [
            {
                "name": "Li Hang",
                "org": "Department of Nephropathy, PUMC Hospital, CAMS, PUMC, Beijing 100730, China."
            },
            {
                "name": "Li Xue-wang"
            },
            {
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            },
            {
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            },
            {
                "name": "Duan Lin"
            },
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            }
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        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [],
        "year": 2003
    },
    "kAnUSKmo": {
        "id": "kAnUSKmo",
        "title": "Pathogenesis of lipid abnormality-induced renal impairment and the effect of statins on chronic kidney diseases",
        "authors": [
            {
                "name": "LI Xue-wang",
                "org": "Department of Nephrology,Peking Union Hospital of Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": "Department of Nephrology,Peking Union Hospital of Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "ZHANG Guo-juan",
                "org": "Department of Nephrology,Peking Union Hospital of Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
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        "venue": "practical journal of clinical medicine",
        "keywords": [
            "Chronic kidney diseases",
            "Glomerular sclerosis",
            "Cardiovascular event",
            "Statins",
            "Blood lipid"
        ],
        "year": 2008
    },
    "DxZlmLwW": {
        "id": "DxZlmLwW",
        "title": "Endoplasmic reticulum stress is involved in acetylated low-density lipoprotein induced apoptosis in THP-1 differentiated macrophages.",
        "authors": [
            {
                "name": "tao"
            },
            {
                "name": "jianling"
            },
            {
                "name": "ruan"
            },
            {
                "name": "xiongzhong"
            },
            {
                "name": "li"
            },
            {
                "name": "hang"
            },
            {
                "name": "xuemei"
            },
            {
                "name": "john"
            },
            {
                "name": "moorhead"
            },
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                "name": "zac"
            },
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        "keywords": [],
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    },
    "orfQe42g": {
        "id": "orfQe42g",
        "title": "Low salt stimulates the expression of cyclooxygenase-2 and its relationship to p38 MAPK signal transduction in a mouse macula densa cell line",
        "authors": [
            {
                "name": "LIU Dong-yan",
                "org": ". Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "LI Xue-wang",
                "org": ". Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "LI Hang",
                "org": ". Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "WEN Yu-bing",
                "org": ". Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "DUAN Lin",
                "org": ". Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "LI Yan",
                "org": ". Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            }
        ],
        "venue": "chinese journal of nephrology",
        "keywords": [
            "Cyclooxygenase 2",
            "Macular densa cells",
            "p38 Mitogen-activated protein kinases",
            "Saline solution",
            "hypotonic",
            "Prostaglandins E",
            "MAP kinase signaling system"
        ],
        "year": 2006
    },
    "WCGObAul": {
        "id": "WCGObAul",
        "title": "Alleviation and Action Mechanism of Shen-Fu Injection for Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cell Injury",
        "authors": [
            {
                "name": "CHEN Xiaolei",
                "org": ",et alNephrology Department of Peking Union Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing %%#%%#"
            },
            {
                "name": "WEN Yubing",
                "org": ",et alNephrology Department of Peking Union Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing %%#%%#"
            },
            {
                "name": "LI Hang",
                "org": ",et alNephrology Department of Peking Union Hospital,Peking Union Medical College and Chinese Academy of Medical Science,Beijing %%#%%#"
            }
        ],
        "venue": "chinese journal of integrated traditional and western nephrology",
        "keywords": [
            "Shen-Fu injeciton Renal hypoxia/reoxygenation Apoptosis Intracelluar calcium overload MCP-1"
        ],
        "year": 2008
    },
    "HDkadELT": {
        "id": "HDkadELT",
        "title": "Advanced Glycation end Products Induced Expression of Connective Tissue Growth Factor and Fibronectin in HK-2 Cells",
        "authors": [
            {
                "name": "DU Xiaoxia",
                "org": ",et alDivision of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing%%#%%#"
            },
            {
                "name": "LI Xuewang",
                "org": ",et alDivision of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing%%#%%#"
            },
            {
                "name": "LI Hang",
                "org": ",et alDivision of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing%%#%%#"
            }
        ],
        "venue": "chinese journal of integrated traditional and western nephrology",
        "keywords": [
            "Advanced glycation end products Connective tissue growth factor Fibronectin"
        ],
        "year": 2007
    },
    "fgRzqk1U": {
        "id": "fgRzqk1U",
        "title": "Risk factors of post-renal biopsy bleeding]",
        "authors": [
            {
                "name": "TAO Jian-ling",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Chao",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "XU Xin-wei",
                "org": " Department of Nephrology,Peoples' hospital,Weifang,Shandong ,China"
            },
            {
                "name": "LI Ji-fang",
                "org": "Department of Nephrology,Puyang Oil Field General Hospital,Pu yang,Henan ,China"
            },
            {
                "name": "YI Na",
                "org": "Department of Nephrology,Angang General Hospital,Anshan,Liaoning ,China"
            },
            {
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "QIN Yan",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "CAI Jian-fang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LIU Bing-yan",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "XU Hong",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [
            "bleeding",
            "renal biopsy",
            "risk factor"
        ],
        "year": 2008
    },
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        "id": "Cf7CsixJ",
        "title": "Effects of rapamycin on intracellular cholesterol homeostasis of glomerular mesangial cell in the presence of interleukin-1 beta.",
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            {
                "name": "Zhang Guo-juan",
                "org": "Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College, Beijing 100730."
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            {
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            },
            {
                "name": "Li Xue-wang"
            }
        ],
        "venue": "chinese medical sciences journal = chung-kuo i hs\u00fceh k'o hs\u00fceh tsa chih / chinese academy of medical sciences",
        "keywords": [
            "low density lipoprotein receptor",
            "atp binding cassette"
        ],
        "year": 2008
    },
    "uzjkGdgt": {
        "id": "uzjkGdgt",
        "title": "Idiopathic membranous nephropathy complicated with malignant hypertension: a case report.",
        "authors": [
            {
                "name": "tao"
            },
            {
                "name": "jianling"
            },
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                "name": "li"
            },
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            },
            {
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            },
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                "name": "yubing"
            },
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                "name": "xuewang"
            }
        ],
        "venue": "chinese medical journal",
        "keywords": [
            "membranous",
            "hypertension",
            "glomerulonephritis",
            "malignant"
        ],
        "year": 2007
    },
    "DKdAHgXs": {
        "id": "DKdAHgXs",
        "title": "Clinical analysis of proteinuria and glomerular lesions in Henoch-Sch\u00f6nlein purpura nephritis of adults]",
        "authors": [
            {
                "name": "Liu Dong-yan",
                "org": "Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China."
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            {
                "name": "Wen Yu-bing"
            },
            {
                "name": "Li Hang"
            },
            {
                "name": "Li Xue-wang"
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        ],
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        "keywords": [],
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    },
    "VcLywrfk": {
        "id": "VcLywrfk",
        "title": "The effects of rapamycin on body weight and insulin resistance in KKAy mice",
        "authors": [
            {
                "name": "WANG De-guang",
                "org": ",et al.Department of Nephrology,Peking Union Medical College Hospital,Beijing ,China"
            },
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                "name": "LI Xue-wang",
                "org": ",et al.Department of Nephrology,Peking Union Medical College Hospital,Beijing ,China"
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            {
                "name": "LI Hang",
                "org": ",et al.Department of Nephrology,Peking Union Medical College Hospital,Beijing ,China"
            }
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        "venue": "chinese journal of diabetes",
        "keywords": [
            "Diabetes mellitus",
            "Body weight",
            "type 2",
            "Insulin resistance",
            "Rapamycin"
        ],
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    },
    "80ZxWB7K": {
        "id": "80ZxWB7K",
        "title": "Effect of Low-flux Polysulphone Membranes on the Serum Levels of Inflammatory Cytokines,C-reactive Protein,Lipoprotein(a),and \u03b2_2 Microglobumin in Hemodialysis Patients",
        "authors": [
            {
                "name": "TAO Jian-ling",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "SUN Yang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
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                "name": "LI Hang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
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                "org": " Department of Nephrology,the First Renmin Hospital of Xi'ning,Xi'ning ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
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        "venue": "acta academiae medicinae sinicae",
        "keywords": [
            "lipoprotein(a)",
            "low-flux polysulphone membranes",
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            "inflammatory cytokines",
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        ],
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        "id": "WQ3xX46v",
        "title": "Non-Hodgkin's lymphoma primarily presenting with Fanconi syndrome and acute kidney injury.",
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                "name": "wenling"
            },
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            },
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            },
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            },
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            },
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                "name": "wei"
            },
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            },
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                "name": "wen"
            },
            {
                "name": "hang"
            },
            {
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            },
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        "venue": "chinese medical sciences journal = chung-kuo i hs\u00fceh k'o hs\u00fceh tsa chih / chinese academy of medical sciences",
        "keywords": [
            "non-hodgkin's lymphoma",
            "acute kidney injury",
            "fanconi syndrome"
        ],
        "year": 2010
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        "id": "RzFDle5e",
        "title": "Research advances in podocyte injury and its role in diabetic nephropathy]",
        "authors": [
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                "org": " Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
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            {
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                "org": " Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
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                "org": " Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
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        "venue": "zhongguo yi xue ke xue yuan xue bao. acta academiae medicinae sinicae",
        "keywords": [
            "podocyte injury",
            "diabetic nephropathy",
            "pathogenesis"
        ],
        "year": 2010
    },
    "rYF5fh0R": {
        "id": "rYF5fh0R",
        "title": "VLDL promotes the expression of lipoprotein lipase in human glomerular mesangial cells",
        "authors": [
            {
                "name": "LI Jing",
                "org": "Department of Nephrology,PUMC Hospital,CAMS & PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS & PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS & PUMC,Beijing ,China"
            },
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                "org": "Department of Nephrology,PUMC Hospital,CAMS & PUMC,Beijing ,China"
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        "venue": "basic & clinical medicine",
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            {
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                "org": "Department of Nephrology, PUMC Hospital, CAMS, PUMC, Beijing 100730, China."
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            },
            {
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        "title": "A clinicopathological analysis of non-haematological malignancy in nephrotic syndrome]",
        "authors": [
            {
                "name": "Ye Wen-ling",
                "org": "Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China."
            },
            {
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            },
            {
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            {
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                "org": "Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
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                "org": "Department of Nephrology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China."
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            {
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            },
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                "name": "zhou"
            },
            {
                "name": "yang"
            },
            {
                "name": "sun"
            },
            {
                "name": "wenling"
            },
            {
                "name": "ye"
            },
            {
                "name": "qi"
            },
            {
                "name": "miao"
            },
            {
                "name": "xuemei"
            }
        ],
        "venue": "chinese medical sciences journal = chung-kuo i hs\u00fceh k'o hs\u00fceh tsa chih / chinese academy of medical sciences",
        "keywords": [
            "infective endocarditis",
            "clinical feature",
            "hemodialysis"
        ],
        "year": 2010
    },
    "cRqOnurH": {
        "id": "cRqOnurH",
        "title": "Stimulatory effect of TNF-\u03b1 on differentiation and maturation of dendritic cells]",
        "authors": [
            {
                "name": "RU Ying",
                "org": " Department of Pediatrics,Peking Union Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "SONG Hong-Mei",
                "org": " Department of Pediatrics,Peking Union Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": " Department of Pediatrics,Peking Union Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            },
            {
                "name": "CUI Wei",
                "org": " Department of Pediatrics,Peking Union Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China"
            }
        ],
        "venue": "zhongguo shi yan xue ye xue za zhi / zhongguo bing li sheng li xue hui = journal of experimental hematology / chinese association of pathophysiology",
        "keywords": [
            "tnf-\u03b1",
            "dendritic cell",
            "cytokine"
        ],
        "year": 2010
    },
    "uQG72asJ": {
        "id": "uQG72asJ",
        "title": "Expression of Cyclooxygenase-2 in a Mouse Macula Densa CellLines and Signal Transduction of NF-\u03baB and AP-1",
        "authors": [
            {
                "name": "LIU Dong-yan",
                "org": ",YE Weng-lingDepartment of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "LI Xue-wang",
                "org": ",YE Weng-lingDepartment of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "LI Hang",
                "org": ",YE Weng-lingDepartment of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            },
            {
                "name": "LI Xue-mei",
                "org": ",YE Weng-lingDepartment of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing , China"
            }
        ],
        "venue": "acta academiae medicinae sinicae",
        "keywords": [
            "cyclooxygenase-2",
            "plasmid",
            "mitogen-activated protein kinase",
            "activator protein-1",
            "nuclear factor kappa B"
        ],
        "year": 2007
    },
    "AKwoGILQ": {
        "id": "AKwoGILQ",
        "title": "Establishment of human mesangial cell line with high expression of type A scavenger receptor and its function",
        "authors": [
            {
                "name": "YE Wen-ling",
                "org": "Div.Nephrology,Peking Union Medical College Hospital,Beijing "
            },
            {
                "name": "LI Xue-wang",
                "org": "Div.Nephrology,Peking Union Medical College Hospital,Beijing "
            },
            {
                "name": "LI Hang",
                "org": "Div.Nephrology,Peking Union Medical College Hospital,Beijing "
            },
            {
                "name": "LI Yan",
                "org": "Div.Nephrology,Peking Union Medical College Hospital,Beijing "
            },
            {
                "name": "DUAN Lin",
                "org": "Div.Nephrology,Peking Union Medical College Hospital,Beijing "
            },
            {
                "name": "JIN Jing",
                "org": "Div.Nephrology,Peking Union Medical College Hospital,Beijing "
            }
        ],
        "venue": "basic & clinical medicine",
        "keywords": [
            "type A scavenger receptor",
            "glomerular mesangial cells",
            "Ac-LDL",
            "Ox-LDL"
        ],
        "year": 2006
    },
    "evPVY0b5": {
        "id": "evPVY0b5",
        "title": "Advanced glycosylation end products induce the expression of connective tissue growth factor in human renal proximal tubular epithelial cells",
        "authors": [
            {
                "name": "DU Xiao-xia",
                "org": " Division of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Xue-wang",
                "org": " Division of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "LI Hang",
                "org": " Division of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "CHEN Li-meng",
                "org": " Division of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "DUAN Lin",
                "org": " Division of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "chinese journal of nephrology",
        "keywords": [
            "Epithelial cells",
            "Connective tissue growth factor",
            "Receptors",
            "advanced",
            "glycosylation end products",
            "Glycosylation end products"
        ],
        "year": 2006
    },
    "PEoPKxgJ": {
        "authors": [
            {
                "name": "Yong YU",
                "org": "State Key Laboratory"
            },
            {
                "name": "Bo YANG",
                "org": "College of information"
            },
            {
                "name": "Ying SUN",
                "org": "College of information"
            }
        ],
        "title": "Identity-based threshold signature and mediated proxy signature schemes",
        "keywords": [
            "bilinear pairings",
            "identity-based",
            "mediated proxy signature",
            "threshold signature",
            "TN918.1"
        ],
        "venue": "Journal of China Universities of Posts and Telecommunications",
        "year": 2007,
        "id": "PEoPKxgJ"
    },
    "5G1L2O2t": {
        "authors": [
            {
                "name": "Xue-Fei Cao",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Xing-Wen Zeng",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Wei-Dong Kou",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Yong Yu",
                "org": "State Key Lab. of Integrated Service Networks"
            }
        ],
        "title": "A novel anonymous authentication scheme over the insecure channel",
        "abstract": "Firstly, an ID-based signature scheme is proposed based on pairings. The bilinearity and non-degeneration of pairings are explored to make the verification result of the signature vary only with the identity of the signer. Then an anonymous authentication scheme is proposed based on the signature scheme. During the authentication, a user chooses a pseudonym by him/herself; then server computes the user's account index from the pseudonym in order to identify and authenticate the user. With our scheme, users are able to travel incognito and to change their passwords at will. Furthermore, there is no need for server to maintain a table of users' passwords or pseudonyms. To the best of our knowledge, the proposed scheme realizes for the first time both user anonymity and authentication security requirements over the insecure channel.",
        "keywords": [
            "Anonymous authentication",
            "Bilinear parings",
            "Identity-based signature"
        ],
        "venue": "Xi'an Dianzi Keji Daxue Xuebao/Journal of Xidian University",
        "year": 2007,
        "id": "5G1L2O2t"
    },
    "ZrBIQsmR": {
        "authors": [
            {
                "name": "Yong Yu",
                "org": "National Key Laboratory of Integrated Service Networks"
            },
            {
                "name": "Bo Yang",
                "org": "College of Information"
            },
            {
                "name": "Fa-Gen Li",
                "org": "National Key Laboratory of Integrated Service Networks"
            },
            {
                "name": "Ming-Wu Zhang",
                "org": "College of Information"
            }
        ],
        "title": "An efficient proxy ring signature scheme",
        "abstract": "An efficient proxy ring signature scheme was proposed. The original signer firstly signs a warrant and then the proxy signers in the ring generate their proxy private keys and finally, each proxy signer can finally generate a proxy ring signature using the modified identity based ring signature proposed by Chow. Strong unforgeability of the new scheme was proven to rely on CDH problem by using forking lemma for ring signature under the random oracle model. No pairing operation is required for the generation of a proxy ring signature and only two pairing operations are required for the verification. Comparing with the existing schemes, the new scheme is more efficient in computation.",
        "keywords": [
            "Ambiguity",
            "Bilinear pairings",
            "Proxy signature",
            "Ring signature"
        ],
        "venue": "Beijing Youdian Daxue Xuebao/Journal of Beijing University of Posts and Telecommunications",
        "year": 2007,
        "id": "ZrBIQsmR"
    },
    "fyZ0hUKR": {
        "authors": [
            {
                "name": "Yong Yu",
                "org": "National Key Lab. of ISN"
            },
            {
                "name": "Bo Yang",
                "org": "College of Information"
            },
            {
                "name": "Fa-Gen Li",
                "org": "School of Computer Science and Engineering"
            },
            {
                "name": "Ying Sun",
                "org": "College of Information"
            }
        ],
        "title": "An ID-based proxy signcryption scheme with fast revocation",
        "keywords": [
            "Digital signature",
            "Identity based",
            "Proxy signcryption"
        ],
        "venue": "Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology",
        "year": 2008,
        "id": "fyZ0hUKR"
    },
    "WvKLJtTI": {
        "authors": [
            {
                "name": "Yong Yu",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Bo Yang",
                "org": "College of Information"
            },
            {
                "name": "Ying Sun",
                "org": "College of Information"
            },
            {
                "name": "Sheng-Lin Zhu",
                "org": "College of Information"
            }
        ],
        "title": "Proxy signature scheme with fast revocation",
        "keywords": [
            "Proxy revocation",
            "Proxy signature",
            "Security mediator"
        ],
        "venue": "Xi'an Dianzi Keji Daxue Xuebao/Journal of Xidian University",
        "year": 2007,
        "id": "WvKLJtTI"
    },
    "O2drnU2u": {
        "authors": [
            {
                "name": "Yong Yu",
                "org": "State Key Laboratory of Integrated Service Networks"
            },
            {
                "name": "Bo Yang",
                "org": "College of Information"
            },
            {
                "name": "Guoqing Yang",
                "org": "State Key Laboratory of Integrated Service Networks"
            }
        ],
        "title": "Identity-based scheme of fair exchange of digital signatures",
        "abstract": "Fair exchange of digital signatures is an important tool for signing digital contracts, e-payment and other electronic commerce actions. An ID-based scheme of fair exchange of digital signature is proposed in this paper. The protocol relies on a trusted third party, but is \"optimistic\", in that the third party is only needed in cases where one player attempts to cheat or simply crashes. The proposed scheme has properties of short signature, low computation and verification cost. It can realize exchange of digital signatures fairly and efficiently. A key feature of our scheme is that it is identity-based, which needs no certificates and has a simple key management. To our best knowledge, this is the first identity-based scheme of fair exchange of digital signatures.",
        "keywords": [
            "Digital signature",
            "Fair exchange",
            "Identity-based"
        ],
        "venue": "Wuhan University Journal of Natural Sciences",
        "year": 2006,
        "id": "O2drnU2u"
    },
    "SvjtXEHN": {
        "authors": [
            {
                "name": "Bo Yang",
                "org": ""
            },
            {
                "name": "Yong Yu",
                "org": ""
            },
            {
                "name": "Fagen Li",
                "org": ""
            },
            {
                "name": "Ying Sun",
                "org": ""
            }
        ],
        "title": "Provably secure identity-based threshold unsigncryption scheme",
        "keywords": [
            ""
        ],
        "venue": "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
        "year": 2007,
        "id": "SvjtXEHN"
    },
    "DSgaGRuB": {
        "id": "DSgaGRuB",
        "title": "Antagonistic activity of essential oils and their main constituents extracted from Ajania fruticulosa and A. potaninii against Ditylenchus destructor",
        "abstract": "The antagonistic activities of essential oils of  Ajania potaninii  and  A. fruticulosa  against  Ditylenchus destructor  were determined by the liquid soak method in 96-well microplates. The main constituents of  A. potaninii  essential oil were 1,8-cineole (22.19%), (+)-camphor (12.84%), (\u2212)-verbenol (13.84%) and borneol (12.67%). The results showed that the essential oils of  A. fruticulosa  (EC 50  = 0.17 mg ml \u22121 ) and  A. potaninii  (EC 50  = 0.27 mg ml \u22121 ) have antagonistic activity against  D. destructor . The results also showed that 1,8-cineole (EC 50  = 0.49 mg ml \u22121 ), myrtenol (EC 50  = 0.40 mg ml \u22121 ) ( A. fruticulosa ) and (\u2212)-verbenol (EC 50  = 1.09 mg ml \u22121 ) ( A. potaninii ) have antagonistic activity. 1,8-Cineole is a key element affecting the antagonistic activity that was found in both essential oils. Several main constituents found in the essential oils had antagonistic effects against  D. destructor . These results provide the basis for future development and utilisation of a substance to control  D. destructor .",
        "keywords": "",
        "authors": [
            {
                "name": "Junyu Liang",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Yan Liu",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Xin-Xin Zhang",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Li-Juan Zhang",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Yan Chen",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Yuan Li",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Weibao Kong",
                "org": "1College of Life Science, Northwest Normal University, Lanzhou 730070, Gansu, P.R. China"
            },
            {
                "name": "Shu-Shan Du",
                "org": "2Beijing Key Laboratory of Traditional Chinese Medicine Protection and Utilization, Beijing Normal University, Beijing\u00a0100875, P.R. China"
            }
        ],
        "venue": "Nematology",
        "year": 2018
    },
    "7uYmKEnj": {
        "id": "7uYmKEnj",
        "title": "Combination of pharmacophore hypothesis, genetic function approximation model, and molecular docking to identify novel inhibitors of S6K1.",
        "abstract": "S6K1 has emerged as a potential target for the treatment for obesity, type II diabetes and cancer diseases. Discovery of S6K1 inhibitors has thus attracted much attention in recent years. In this investigation, a hybrid virtual screening method that involves pharmacophore hypothesis, genetic function approximation (GFA) model, and molecular docking technology has been used to discover S6K1 inhibitors especially with novel scaffolds. The common feature pharmacophore hypothesis and GFA regression model of S6K1 inhibitors were first developed and applied in a virtual screen of the Specs database for retrieving S6K1 inhibitors. Then, the molecular docking method was carried out to re-filter these screened compounds. Finally, 60 compounds with promising S6K1 inhibitory activity were carefully selected and have been handed over to the other group to complete the follow-up compound synthesis (or purchase) and activity test.",
        "keywords": [
            "S6K1",
            "Pharmacophore model",
            "Genetic function approximation model",
            "Molecular docking",
            "Virtual screening"
        ],
        "authors": [
            {
                "name": "Hui Zhang",
                "org": "Northwest Normal University(Northwest Normal University),Lanzhou,China"
            },
            {
                "name": "Mingli Xiang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Junyu Liang",
                "org": "Northwest Normal University(Northwest Normal University),Lanzhou,China"
            },
            {
                "name": "Tao Zeng",
                "org": "Northwest Normal University(Northwest Normal University),Lanzhou,China"
            },
            {
                "name": "Xiaonuo Zhang",
                "org": "Northwest Normal University(Northwest Normal University),Lanzhou,China"
            },
            {
                "name": "Ji Zhang",
                "org": "Northwest Normal University(Northwest Normal University),Lanzhou,China"
            },
            {
                "name": "Shengyong Yang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            }
        ],
        "venue": "Molecular diversity",
        "year": 2013
    },
    "2NK5Uuev": {
        "id": "2NK5Uuev",
        "title": "Preparation and characterization of Artemisia sphaerocephala gum composite hydrogels: evaluation of rheological and release behaviour",
        "abstract": "Novel semi-IPN hydrogels composed of sodium alginate (SA) and Artemisia sphaerocephala gum (ASG) were prepared using a water/ethanol method. SA/ASG hydrogels showed enhanced mechanical properties, excellent swelling, and good release capabilities, which are crucial for medical and pharmaceutical applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Zongyi Zhang",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Tiantian Chen",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Hao Wang",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Hui Zhang",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Junyu Liang",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Weibao Kong",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Jian Yao",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Junlong Wang",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            },
            {
                "name": "Ji Zhang",
                "org": "College of Life Science, Northwest Normal University,Lanzhou 730070,China"
            }
        ],
        "venue": "New Journal of Chemistry",
        "year": 2019
    },
    "XDkreeSr": {
        "id": "XDkreeSr",
        "title": "Synthesis and structure characterization of sulfated galactomannan from fenugreek gum.",
        "abstract": "Sulfated derivatives of the galactomannan family have multiple biological activities. In the present study, sulfated galactomannan from fenugreek gum (SFG) were prepared by chlorosulfuric acid/pyridine (CSA/Py) method. In order to optimize the reaction conditions of SFG with high degree of substitution (DS), the experiment optimum conditions of the sulfation were determined by Box-Behnken design (BBD). The quadratic regression model analysis confirmed that reaction time was the most significant parameter for the impact of DS. Under the selected conditions, a high DS of 0.490 was obtained. Results of FT-IR and X-ray photoelectron spectroscopy (XPS) indicated the present of SO group. In C NMR spectroscopy, the original C-6 peaks did not disappear completely and the newly peaks appeared at \u03b4 63.2 and 64.0 illustrating the incomplete substitution were predominantly on C-6 position. After sulfation, size exclusion chromatography combined with multi-angle laser light scattering (SEC-MALLS) detected all the predominantly (M) of sulfated derivatives decrease rapidly. The introduction of the electrostatic interaction of negatively charged SO groups and the decrease in M could have a significant effect on its biological activity.",
        "keywords": [
            "Box-Behnken design",
            "Fenugreek gum",
            "Sulfation"
        ],
        "authors": [
            {
                "name": "Zongyi Zhang",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Hao Wang",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Tiantian Chen",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Hui Zhang",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Junyu Liang",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Weibao Kong",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Jian Yao",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China; Bioactive Products Engineering Research Center For Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Ji Zhang",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China; Bioactive Products Engineering Research Center For Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, China."
            },
            {
                "name": "Junlong Wang",
                "org": "College of Life Science, Northwest Normal University, Lanzhou 730070, China; Bioactive Products Engineering Research Center For Gansu Distinctive Plants, Northwest Normal University, Lanzhou 730070, China. Electronic address: nuno-vai@163.com."
            }
        ],
        "venue": "International journal of biological macromolecules",
        "year": 2018
    },
    "l4ZVCure": {
        "authors": [
            {
                "name": "Jin Song Zhao",
                "org": "State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences"
            },
            {
                "name": "Bin Zhao",
                "org": "State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences"
            },
            {
                "name": "Jian Wei Li",
                "org": "State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences"
            },
            {
                "name": "De Ru Xu",
                "org": "Guangzhou Institute of Geochemistry, Chinese Academy of Sciences"
            },
            {
                "name": "Mou Chun He",
                "org": "State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences"
            },
            {
                "name": "Jian Ping Zheng",
                "org": "State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences"
            }
        ],
        "title": "Magma control of magmatic skarn to the formation of some deposits of skarn type: Evidence from Laser Raman analyses of inclusions in minerals",
        "abstract": "This paper will report Raman analytical results of twenty-three inclusions in garnets, pyroxenes and dolomite or calcite from 9 deposits including Han-Xing iron deposits, Mengku iron deposit and Yangjiazhangzi molybdenum deposit in North China. The purpose of this study is to confirm whether these mineralized skarn minerals contain melt inclusions and fluid-melt inclusions and to obtain the information about their phase state characteristics and phase compositions as well as their distribution situations (local, accidental) and scales (widespread or common). Laser Raman analysis results showed that the all studied skarns contain melt inclusions and/or fluid-melt inclusions, they are direct evidence of magmatic skarns. Combined geological background, thermometry researches for inclusions in minerals of magma-genetic skarns from other areas of China and Laser Raman analysis results of present paper, the origin and formation mechanism of investigated skarns and magma control of magma-genetic skarns to the formation of some skarn type deposits from North China were discussed. Believes that melt inclusions and fluid-melt inclusions-bearing mineralized skarns must be magmatic origin. Their distribution ranges and scale are widespread and very large. Distribution of some skarn deposits from North China in time and space as well as scale is controlled by magmatic skarns distributed in given regions. We hope this study will help to broaden ideas in the study of metallogenic regularity and deep prospecting and exploration for ore deposits of skarn type.",
        "keywords": [
            "Fluid-melt inclusions",
            "Laser Raman",
            "Melt inclusion",
            "North China",
            "Skarn"
        ],
        "venue": "Acta Petrologica Sinica",
        "year": 2015,
        "id": "l4ZVCure"
    },
    "IIsCL26T": {
        "authors": [
            {
                "name": "Jinsong Zhao",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "Bin Zhao",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "Bing Rao",
                "org": "Department of Earth Sciences"
            }
        ],
        "title": "Experimental study on the partition behaviour of Ta, Nb and W between different phases in the processes of crystallization differentiation of albite granitic magma",
        "abstract": "",
        "keywords": [
            "Partition behaviour of Ta, Nb and W",
            "Process of crystallization differentiation of magma"
        ],
        "venue": "Chinese Science Bulletin",
        "year": 1997,
        "id": "IIsCL26T"
    },
    "F7hOx1Jc": {
        "authors": [
            {
                "name": "Bin Zhao",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "Jinsong Zhao",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "Zhaolin Li",
                "org": "Department of Geology"
            },
            {
                "name": "Zhongze Zhang",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "Zhuolun Peng",
                "org": "Department of Geology"
            }
        ],
        "title": "Characteristics of melt inclusions in skarn minerals from Fe, Cu(Au) and Au(Cu) ore deposits in the region from Daye to Jiujiang",
        "abstract": "A vast amount of the melt inclusions and fluid-melt inclusions have been found in skarn minerals from Fe, Cu(Au) and Au(Cu) ore deposits distributed from Daye to Jiujiang along the Yangtze River besides vapor-liquid inclusions. The melt inclusions are many and varied in shape. They mainly consist of crystallized silicate phases (C",
        "keywords": [
            "Magmatic origin",
            "Melt inclusion",
            "Skarn"
        ],
        "venue": "Science in China, Series D: Earth Sciences",
        "year": 2003,
        "id": "F7hOx1Jc"
    },
    "yPqI7ych": {
        "authors": [
            {
                "name": "JinSong Zhao",
                "org": "Graduate School"
            },
            {
                "name": "Bin Xia",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "XueLin Qiu",
                "org": "South China Sea Institute of Oceanology"
            },
            {
                "name": "Bin Zhao",
                "org": "Guangzhou Institute of Geochemistry"
            },
            {
                "name": "DeRu Xu",
                "org": "Department of Resources and Environment"
            },
            {
                "name": "ZuoHai Feng",
                "org": "Department of Resources and Environment"
            },
            {
                "name": "ZhaoLin Li",
                "org": "Department of Geology"
            },
            {
                "name": "GanFu Shen",
                "org": "Chengdu Institute of Geology and Mineral Resources"
            },
            {
                "name": "RuiZhong Hu",
                "org": "Institute of Geochemistry"
            },
            {
                "name": "WenChao Su",
                "org": "Institute of Geochemistry"
            },
            {
                "name": "ChaoJian Qin",
                "org": "Institute of Geochemistry"
            },
            {
                "name": "WeiMin Qin",
                "org": "Department of Geology and Surveying of Hainan Iron and Steel Corporation"
            },
            {
                "name": "Xian Fu",
                "org": "Department of Geology and Surveying of Hainan Iron and Steel Corporation"
            },
            {
                "name": "ZhiGao Hu",
                "org": "Department of Geology and Surveying of Hainan Iron and Steel Corporation"
            }
        ],
        "title": "Finding of melt inclusion in garnet from skarn of Shilu iron deposit, Hainan province",
        "abstract": "Observations of thin sections of rocks from a fresh and representative specimen of iron ore of skarn type under polarized light microscope, electron probing analyses and Raman analyses for minerals and melt inclusions were carried out. Melt inclusions in garnet have been found. Main characteristics of these inclusions are great disparities in varying sizes and distributions in groups and in zones, the largest melt inclusion is up to 98\u03bcm \u00d7 5\u03bcm, the smallest one is about 1\u03bcm \u00d7 1\u03bcm, the majority of the melt inclusions are 5 - 30\u03bcm in length and 2 - 7 \u03bcm in width. Some melt inclusions are scattered within garnet in isolation. They have variety in the shape and they total spindle, dumbbell, string of beads, lotus root, round-like and xenomorphic forms. Stadied skarn mainly consists of garnet with high component of andradite, magnetite, quartz, tremolite and pyroxene, apatite with directional and sporadic distributions, minor zircon and sphene. Melts trapped by melt inclusions in garnet originally consisted of Ca, Fe, Al and volatile components (H",
        "keywords": [
            "Garnet",
            "Melt inclusion",
            "Shilu iron deposit",
            "Skarn"
        ],
        "venue": "Acta Petrologica Sinica",
        "year": 2008,
        "id": "yPqI7ych"
    },
    "LojHbTlB": {
        "id": "LojHbTlB",
        "title": "Comparison of Standard Breath-Held, Free-Breathing, and Compressed Sensing 2D Gradient-Recalled Echo MR Elastography Techniques for Evaluating Liver Stiffness.",
        "abstract": "Free-breathing and CS accelerated 2D GRE MRE techniques yield similar results to the conventional breath-held technique with only slight bias and may be useful in pediatric and adult patients with limited ability to breath-hold.",
        "keywords": [
            "MR elastography",
            "comparative research",
            "compressed sensing",
            "gradient-recalled echo",
            "liver"
        ],
        "authors": [
            {
                "name": "Cara E Morin",
                "org": "1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229."
            },
            {
                "name": "Jonathan R Dillman",
                "org": "2 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH."
            },
            {
                "name": "Suraj D Serai",
                "org": "3 Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA."
            },
            {
                "name": "Andrew T Trout",
                "org": "2 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH."
            },
            {
                "name": "Jean A Tkach",
                "org": "2 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH."
            },
            {
                "name": "Hui Wang",
                "org": "4 Philips Healthcare, Best, The Netherlands."
            }
        ],
        "venue": "AJR. American journal of roentgenology",
        "year": 2018
    },
    "BulCcyOA": {
        "id": "BulCcyOA",
        "title": "Comparison of Standard Breath-Held, Free-Breathing, and Compressed Sensing 2D Gradient-Recalled Echo MR Elastography Techniques for Evaluating Liver Stiffness.",
        "abstract": "Free-breathing and CS accelerated 2D GRE MRE techniques yield similar results to the conventional breath-held technique with only slight bias and may be useful in pediatric and adult patients with limited ability to breath-hold.",
        "keywords": [
            "MR elastography",
            "comparative research",
            "compressed sensing",
            "gradient-recalled echo",
            "liver"
        ],
        "authors": [
            {
                "name": "Cara E Morin",
                "org": "1 Department of Radiology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229."
            },
            {
                "name": "Jonathan R Dillman",
                "org": "2 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH."
            },
            {
                "name": "Suraj D Serai",
                "org": "3 Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA."
            },
            {
                "name": "Andrew T Trout",
                "org": "2 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH."
            },
            {
                "name": "Jean A Tkach",
                "org": "2 Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH."
            },
            {
                "name": "Hui Wang",
                "org": "4 Philips Healthcare, Best, The Netherlands."
            }
        ],
        "venue": "AJR. American journal of roentgenology",
        "year": 2018
    },
    "UfWodPzG": {
        "id": "UfWodPzG",
        "title": "Liver Stiffness Measurements with MR Elastography: Agreement and Repeatability across Imaging Systems, Field Strengths, and Pulse Sequences.",
        "abstract": "Purpose To prospectively assess agreement and repeatability of magnetic resonance (MR) elastography liver stiffness measurements across imager manufacturers, field strengths, and pulse sequences. Materials and Methods This prospective cross-sectional study was approved by the institutional review board; informed consent was obtained from all subjects. On the basis of an a priori power calculation, 24 volunteer adult subjects underwent MR elastography with four MR imaging systems (two vendors) and multiple pulse sequences (two-dimensional [2D] gradient-echo [GRE] imaging, 2D spin-echo [SE] echo-planar imaging, and three-dimensional [3D] SE echo-planar imaging). Each sequence was performed twice in each patient with each imaging system. Intraclass correlation coefficients (ICCs) were used to assess agreement and repeatability. P < .05 was considered indicative of a statistically significant difference. Results Pairwise ICCs were 0.67-0.82 and 0.62-0.83 for agreement between pulse sequences across manufacturers (n = 4) and field strengths (n = 5), respectively. ICCs were 0.45-0.90 for pairwise agreement between sequences while fixing manufacturer and field strength (n = 8). Test-retest repeatability across the various manufacturer, field strength, and pulse sequence combinations (n = 10) was excellent (ICCs, 0.77-0.94). The overall ICC for all manufacturer, field strength, and sequence combinations (n = 10) was 0.68 (95% confidence interval [CI]: 0.55, 0.82). ICC according to field strength was 0.78 (95% CI: 0.67, 0.88) at 1.5 T (n = 5) and 0.64 (95% CI: 0.49, 0.78) at 3.0 T (n = 5). ICCs according to vendor were 0.83 (95% CI: 0.73, 0.91) (n = 4) and 0.65 (95% CI: 0.51, 0.79) (n = 6). Average patient level variance was 0.042 kPa, with a coefficient of variation of 10.7%. Conclusion MR elastography is a reliable method for assessing liver stiffness, with small amounts of variability between imager manufacturers, field strengths, and pulse sequences.  RSNA, 2016.",
        "keywords": "",
        "authors": [
            {
                "name": "Andrew T Trout",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            },
            {
                "name": "Suraj Serai",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            },
            {
                "name": "Alana D Mahley",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            },
            {
                "name": "Hui Wang",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            },
            {
                "name": "Yue Zhang",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            },
            {
                "name": "Bin Zhang",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            },
            {
                "name": "Jonathan R Dillman",
                "org": "From the Department of Radiology (A.T.T., S.S., A.D.M., J.R.D.) and Department of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229-3026; Philips Healthcare, Cincinnati, Ohio (H.W.); and Department of Mathematical Science, University of Cincinnati, Cincinnati, Ohio (Y.Z.)."
            }
        ],
        "venue": "Radiology",
        "year": 2016
    },
    "xNqNS0CY": {
        "id": "xNqNS0CY",
        "title": "Respiratory-triggered spin-echo echo-planar imaging-based mr elastography for evaluating liver stiffness.",
        "abstract": "1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018.",
        "keywords": [
            "MR elastography",
            "liver stiffness",
            "respiratory triggering",
            "spin-echo echo-planar imaging"
        ],
        "authors": [
            {
                "name": "Hui Wang",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."
            },
            {
                "name": "Jean A Tkach",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."
            },
            {
                "name": "Andrew T Trout",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."
            },
            {
                "name": "Charles L Dumoulin",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."
            },
            {
                "name": "Jonathan R Dillman",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA."
            }
        ],
        "venue": "Journal of magnetic resonance imaging : JMRI",
        "year": 2018
    },
    "OG96IaF1": {
        "id": "OG96IaF1",
        "title": "Non-contrast three-dimensional gradient recalled echo Dixon-based magnetic resonance angiography/venography in children.",
        "abstract": "Magnetic resonance imaging (MRI) has been considered a valuable diagnostic tool for noninvasive imaging of the vasculature in children and adults for more than two decades. While a variety of non-contrast MRI methods have been described for imaging of both arteries and veins (e.g., time-of-flight, phase contrast, and balanced steady-state free precession imaging), contrast-enhanced magnetic resonance angiography/venography are the most commonly employed vascular imaging techniques due to their high spatial and contrast resolutions and general reliability. In this technical innovation article, we describe a novel 3-D respiratory-triggered gradient recalled echo Dixon-based MR angiography/MR venography technique that provides high-resolution anatomical imaging of the vasculature of the neck, body and extremities without the need for intravenous contrast material or breath-holding.",
        "keywords": [
            "Children",
            "Dixon fat-water separation",
            "Magnetic resonance angiography",
            "Magnetic resonance venography",
            "Vascular imaging"
        ],
        "authors": [
            {
                "name": "Jonathan R Dillman",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. jonathan.dillman@cchmc.org."
            },
            {
                "name": "Andrew T Trout",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA."
            },
            {
                "name": "Arnold C Merrow",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA."
            },
            {
                "name": "Ryan A Moore",
                "org": "Heart Institute, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA."
            },
            {
                "name": "Mantosh S Rattan",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA."
            },
            {
                "name": "Eric J Crotty",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA."
            },
            {
                "name": "Robert J Fleck",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA."
            },
            {
                "name": "Masami Yoneyama",
                "org": "Philips Healthcare, Best, The Netherlands."
            },
            {
                "name": "Hui Wang",
                "org": "Philips Healthcare, Best, The Netherlands."
            },
            {
                "name": "Jean A Tkach",
                "org": "Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA."
            }
        ],
        "venue": "Pediatric radiology",
        "year": 2018
    },
    "3EImKwqo": {
        "authors": [
            {
                "name": "Yong Yu",
                "org": "SOA Key Laboratory for Polar Science"
            },
            {
                "name": "Hui-Rong Li",
                "org": "SOA Key Laboratory for Polar Science"
            },
            {
                "name": "Yin-Xin Zeng",
                "org": "SOA Key Laboratory for Polar Science"
            },
            {
                "name": "Bo Chen",
                "org": "SOA Key Laboratory for Polar Science"
            }
        ],
        "title": "Bacillus beringensis sp. nov., a psychrotolerant bacterium isolated from the Bering Sea",
        "abstract": "Psychrotolerant Bacillus-like strains BR035",
        "keywords": [
            "Bacillus",
            "Bacillus beringensis sp. nov.",
            "Bering sea",
            "Psychrotolerant bacteria"
        ],
        "venue": "Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology",
        "year": 2011,
        "id": "3EImKwqo"
    },
    "IdxwEQVD": {
        "id": "IdxwEQVD",
        "title": "Application of a new catheter to be determining cardiac output through cor sinistrum with thermodilution]",
        "abstract": "To introduce a new device and catheter to be determining cardiac output through cor sinistrum with thermodilution.Own control was introduced in eight dogs. A pulmonary thermodilution catheter was used through the cor dextrum of the dogs; The new-design catheter was used through artery, and there were two situs to fix:its ahead in left atrium and the ahead near to aortic root. Determine cardiac output (CO) under four circumstances: controlled respiration, apnoea, in controlled hypotension, after controlled hypotension.There was no significant difference among the parameters (CO and cardiac index) of all circumstances. The CO determined by the pulmonary thermodilution catheter and those by the new-design catheter in two situs were positive correlation, and the gamma were 0.986, 0.989; likewise, the cardiac index (CI) was positive correlation, and the gamma were 0.983, 0.985. The CO and CI by the new-design catheter between two situs were positive, and the gamma were 0.992, 0.988.The parameters by the new-design catheter and those by the pulmonary thermodilution catheter were concordant. In comparison with the pulmonary thermodilution catheter, the new-design catheter had simple device and could be easily operated.",
        "keywords": [
            "thermodilution",
            "catheterization",
            "swan-ganz",
            "cardiac output"
        ],
        "authors": [
            {
                "name": "Huang Fei",
                "org": "Department of Anesthesiology, Shenzhen Hospital, Peking University, Shenzhen 518035, China."
            },
            {
                "name": "Li Xiao-Ling",
                "org": ""
            },
            {
                "name": "Zheng Li-Min",
                "org": ""
            },
            {
                "name": "Wang Ming-Ling",
                "org": ""
            },
            {
                "name": "Li Yu-Mei",
                "org": ""
            },
            {
                "name": "Liu Xiao-Ling",
                "org": ""
            }
        ],
        "venue": "Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology",
        "year": 2008
    },
    "cECr0Dn2": {
        "id": "cECr0Dn2",
        "title": "Influence of beating and arrested heart surgery with cardiopulmonary bypass on prostaglandins",
        "abstract": "Objective It is to observe the change of prostaglandins during beating and arrested heart surgery with cardiopulmonary bypass and postoperation,evaluation the myocardial ischemia-reperfusion injury of beating heart surgery and the effect of myocardial protection.Methods 20 cases of congenital heart disease open heart surgery with cardiopulmonary bypass were randomly divided into beating group and cardioplegia group.Blood samples were collected respectively before operation(T1),CPB 30 min(T2),the end of CPB(T3),120 min after CPB(T4),24 h after CPB(T5) to measure the concentration of TXB2,6-Ket-PGF1\u03b1,8-Iso-PGF2\u03b1,and calculate the ratio of TXB2/6-Ket-PGF1\u03b1.Results Plasma concentrations of TXB2,6-Ket-PGF1\u03b1,8-Iso-PGF2\u03b1 and the ratio of TXB2/6-Ket-PGF1\u03b1 were raised significantly in both groups at T2 and T3(P<0.01).After CPB(from T3 to T5),these indexes dropped eventually,but the plasma concentration of TXB2,6Ket-PGF1\u03b1,8-Iso-PGF2\u03b1 and the ratio of TXB2/6-Ket-PGF1\u03b1 were higher than those at T1(P<0.01 or 0.05),except the level of 8-Iso-PGF2\u03b1 and the ratio of TXB2/6-Ket-PGF1\u03b1 in beating group at T5. The ratio of TXB2/6-Ket-PGF1\u03b1(from T3 to T5) in beating group decreased more rapidly than those in cardioplegia group,the level of 8-Iso-PGF2\u03b1 in beating group were lower than those in cardioplegia group at T2,T3 and T4(P<0.05).Conclusion Beating heart surgery can improve the ratio of TXB2/6-Ket-PGF1\u03b1 and inhibit oxidative stress,which can relieve CPB induced myocardium ischemic reperfusion injury,have an effect on myocardial protection.",
        "keywords": [
            "ischemia reperfusion injury",
            "prostaglandin",
            "beating heart",
            "cardiopulmonary bypass"
        ],
        "authors": [
            {
                "name": "Wan Fan",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Zheng Limin",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Huang Fei",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Ren Mingming",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Wu Zhicheng",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            }
        ],
        "venue": "Modern Journal of Integrated Traditional Chinese and Western Medicine",
        "year": 2009
    },
    "nm3p1o0L": {
        "id": "nm3p1o0L",
        "title": "Clinical application of Ilioinguinal/Iliohypogastric nerve block in pediatric anesthesia of inguinal incision surgery",
        "abstract": "Objective:To investigate the clinical application of IINB(Ilioinguinal/Iliohypogastric Nerve Block) in pediatric anesthesia of inguinal incision surgery;and evaluate the effect on the early period of postoperative analgesia.Methods:Forty-eight children required inguinal incision surgeries were randomly divided into two groups: IINB group(n=24) and control group(n=24).In IINB group,IINB was administed after basal anesthesia,while in control group,followed with basal anesthesia,total intravenous anesthesia was administered.Four indexes including the anesthesia effect of IINB at the point of cutting skin,the total dosages of propofol and(or) ketamine during operation,the recover time from anesthesia and the score of CHEOPS(Children's Hospital Eastern Ontario Pain Scale) before leaving PACU(postanesthesia care unit) were observed.Results:The anesthesia effect during operation showed better in IINB group than in control group(P<0.01).The total dosage of propofol used in operation in IINB group was less than that in control group,and ketamine need not be used in IINB group.Furthermore,the effect on analgesia in IINB group was better than that in control group at the time of leaving PACU.Conclusion:IINB combined with basal anesthesia is a proper choice for inguigal region surgery in pediatrics.In addition,IINB can provide satisfactory postoperative analgesia.",
        "keywords": [
            "Inguina",
            "Anesthesia",
            "Nerve Block",
            "Postoperative analgesia",
            "Illioinguinal/Iliohypogastric"
        ],
        "authors": [
            {
                "name": "HUANG Fei",
                "org": " et al.Department of Anesthesiology,Shenzhen Hospital,Peking University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "LI Xiao-Ling",
                "org": " et al.Department of Anesthesiology,Shenzhen Hospital,Peking University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "WAN Fan",
                "org": " et al.Department of Anesthesiology,Shenzhen Hospital,Peking University,Shenzhen ,Guangdong,China"
            }
        ],
        "venue": "Maternal and Child Health Care of China",
        "year": 2007
    },
    "QNeJyoWR": {
        "id": "QNeJyoWR",
        "title": "Effect of noninvasive limb ischemic preconditioning on myocardial ischemia reperfusion injury",
        "abstract": "Objective It is to observe the influence of noninvasive limb ischemic preconditioning(NPC) on myocardial ischemia-reperfusion injury during cardiopulmonary bypass cardiac surgery.Methods 20 patients required cardiopulmonary bypass cardiac surgeries were randomly divided into 2 groups.In group N,two tourniquets wrapped around both upper extremities of each patient were inflated for 8 min and deflated 5 min for three times after anesthesia.The other procedures were the same as group C.Blood samples were collected from central vein respectively before operation(T1\u03b1),30 min after aortic clamp(T2),30 min(T3),120 min(T4),24 h(T5) after aortic opened to measure the concentration of TXB2,6-Ket-PGF1\u03b1,8-Iso-PGF2\u03b1and calculate ratio of TXB2/6-Ket-PGF1\u03b1.Results Plasma concentration of TXB2,6-Ket-PGF1\u03b1,8-IsoPGF2\u03b1 and the ratio of TXB2/6-Ket-PGF1\u03b1.raised significantly in both groups at T2 and T3(P<0.01).During reperfusion,the ratio of TXB2/6-Ket-PGF1\u03b1(from T3 to T5) in group N decreased more rapidly than those in group C,the level of 8-Iso-PGF2\u03b1in group N was lower than that in group C at T4(P<0.05).While at T5,the level of 6-Ket-PGF1\u03b1 in group N was higher than that in group C(P<0.05).Conclusion Noninvasive limb ischemic preconditioning can relieve myocardium ischemic-reperfusion injury to protect myocardium by improving disbalance of TXB2/6-Ket-PGF1\u03b1 and inhibiting oxidative stress.",
        "keywords": [
            "limb ischemic preconditioning",
            "extracorporeal circulation",
            "myocardium ischemic-reperfusion injury"
        ],
        "authors": [
            {
                "name": "Wan Fan",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Yang Baxian",
                "org": "The People's Hospital of Beijing University,Beijing ,China"
            },
            {
                "name": "Zheng Limin",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Wang Mingling",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            },
            {
                "name": "Huang Fei",
                "org": "Shenzhen Hospital of Beijing University,Shenzhen ,Guangdong,China"
            }
        ],
        "venue": "Modern Journal of Integrated Traditional Chinese and Western Medicine",
        "year": 2009
    },
    "vdovtyNx": {
        "id": "vdovtyNx",
        "title": "A experimental study on cardiac output measurement with lift ventricular catheterization",
        "abstract": "Objective To introduce a new device and catheter for determining cardiac output(CO) through cor sinistrum with thermodilution.Methods Own control was introduced in eight dogs.A pulmonary thermodilution catheter was used through the cor dextrum of the dogs.The new-design catheter was used through artery,and there were two situs to fix:its ahead in left artrium and the ahead near to aortic root.The CO was recorded under four circumstances of controlled respiration,apnoea,in controlled hypotension,and after controlled hypotension.Results There was no significant difference among the parameters(CO and cardiac index) of all circumstances.The CO determined by the pulmonary thermodilution catheter and those by the new-design catheter in two situs were positively correlated(\u03b3=0.986 or \u03b3=0.989),so did the cardiac index(\u03b3=0.983 or \u03b3=0.985).The CO and cardiac index by the new-design catheter between two situs were positively correlated(\u03b3=0.992 or \u03b3=0.988).Conclusion The parameters by the new-design catheter and those by the pulmonary thermodilution catheter were concordant.In comparison with the pulmonary thermodilution catheter,the new-design catheter is a simple device and could be easily operated.",
        "keywords": [
            "Catheterization",
            "Cardiac output",
            "Monitoring"
        ],
        "authors": [
            {
                "name": "HUANG Fei",
                "org": ",WAN Ming-ling,et al.Department of Anesthesiology,Shenzhen Hospital,Peking University,Shenzhen ,China"
            },
            {
                "name": "ZHENG Li-min",
                "org": ",WAN Ming-ling,et al.Department of Anesthesiology,Shenzhen Hospital,Peking University,Shenzhen ,China"
            }
        ],
        "venue": "The Journal of Clinical Anesthesiology",
        "year": 2007
    },
    "hWmdzKH1": {
        "id": "hWmdzKH1",
        "title": "The Protective Effect of Ligustrazine on Myocardial Ischemia/Reperfusion Injury in Rabbits",
        "abstract": "Objective To investigate the protective effect of ligustrazine injection on myocardial ischemia/reperfusion injury in rabbits.Methods We investigated the activities of creatine phosphokinase(CPK),lactic dehydrogenase(LDH),superoxide dismutase(SOD) and the content of malondialdehyde(MDA) in plasm and myocardium after ischemia and reperfusion.24 rabbits were randomly divided into 3 groups:group \u2160(sham group),group \u2161(ischemia/reperfusion group) and group \u2162(ligutrazine group).Results After ischemia,the activities of CPK,LDH in plasm in group \u2161 increased,the activity of SOD decreased,and all the parameters changed further after reperfusion;after reperfusion,compared with group \u2161,the activity of LDH in plasm in group \u2162 decreased.All the parameters in myocardium in group \u2161 differed significantly between the ischemic area and the non-ischemic area;compared with group \u2161,the activities of CPK,SOD in the ischemic myocardium in group \u2162 increased and the content of MDA decreased.Conclusion Ligustrazine injection could exert protective effect on myocardial ischemia/reperfusion injury.",
        "keywords": [
            "Ischemia/reperfusion injury",
            "Rabbit",
            "Ligustrazine"
        ],
        "authors": [
            {
                "name": "ZHANG Yan",
                "org": "Department of Anesthesiology,Shenzhen Hospital of the Peakimg University,Shenzhen "
            },
            {
                "name": "ZHENG Limin",
                "org": "Department of Anesthesiology,Shenzhen Hospital of the Peakimg University,Shenzhen "
            },
            {
                "name": "HUANG Fei",
                "org": "Department of Anesthesiology,Shenzhen Hospital of the Peakimg University,Shenzhen "
            },
            {
                "name": "TIAN Yuke",
                "org": "Tongji Hospital of Tongji Medical College of Huazhong University of Science & Technology,Wuhan "
            }
        ],
        "venue": "China Modern Doctor",
        "year": 2009
    },
    "TuUusVPT": {
        "id": "TuUusVPT",
        "title": "Construction Mode and Practice for the Development of the Undergraduate's Tutorial System in Research University",
        "abstract": "The current situation on the development of the tutorial system for undergraduates in university is analysed.The main existing problems and development dilemma has been pointed out.As an example,the achievement of the undergraduate's tutorial system in China University of Geosciences(Beijing) is summarized.Individual guide,equal relationship and interactive teaching form the nucleus idea of the innovative talent training in research university.The development train of thought and construction mode of the undergraduate's tutorial system based on the counsellor system is proposed and discussed.",
        "keywords": [
            "research university",
            "tutorial system for undergraduates",
            "construction mode"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": "China University of Geosciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Geological Education",
        "year": 2013
    },
    "VYByTFNG": {
        "id": "VYByTFNG",
        "title": "Study on the distribution of landslides triggered by the May 12,2008 Wenchuan earthquake in two square typical regions",
        "abstract": "Tens of thousands of landslides were triggered by Wenchuan earthquake.The purpose of this study was to find correlations of landslide occurrence with formation lithology,slope gradient,elevation,peak ground acceleration,and distance from seismogenic fault in two selected landslide incidental areas(A /B),using spatial analysis methods.The results show that rock groups of graphite schist and quartzite had the most concentrated landslide activities in area A,while siltstone,sandstone,and chert rock groups in area B.The landslide susceptibility levels have a positive correlation with slope steepness in both the areas.The advantage slope gradient is 44\u00b0in area A and 38\u00b0 in area B.There were also relations between elevation and earthquakeinduced landslide distribution.Peak ground acceleration has no positive or consistent correlation with earthquake-induced landslide occurrence,but the distance from seismogenic fault shows approximate positive correlation with landsliding.There is a higher landslide distribution area ratio on the upper plate than on the lower plate.",
        "keywords": [
            "spatial distribution",
            "Wenchuan earthquake",
            "geographic information systems",
            "statistical analysis",
            "landslide"
        ],
        "authors": [
            {
                "name": "XU Chong",
                "org": " Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China; Graduate University of the Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "DAI Fu-Chu",
                "org": " Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "YAO Xin",
                "org": " Key Laboratory of Neotectonic and Geohazard,Ministry of Land and Resources,Beijing ,China; Institute of Geomechanics,Chinese Academy of Geological Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jian",
                "org": ""
            },
            {
                "name": "TU Xin-Bin",
                "org": " Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "XIAO Jian-Zhang",
                "org": " Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "SUN Yu",
                "org": " China University of Geosciences,Beijing ,China"
            }
        ],
        "venue": "Journal of the Graduate School of the Chinese Academy of Sciences",
        "year": 2010
    },
    "HDUew8LM": {
        "id": "HDUew8LM",
        "title": "Genetic Mechanism of the Major Debris-flow Deposits at Benzilan-Dari Segment,the Upper Jinsha River",
        "abstract": "The Quaternary debris-flow accumulations can provide rich information for geomorphic evolution,tectonic movement and climate change.There occur many Quaternary debris-flow accumulations in the southeastern(SE) marginal area of the Tibetan Plateau(TP),especially in valleys of the upper reach of the Jinsha River.The river segment between Benzilan to Dari of the upper Jinsha River belongs to the dry-hot valley type in the Henduan Mountainous region.Major old debris-flow accumulations are well developed in this area,however their formative causes have not been studied.The Waka debris flows is one of the major debris flows in the river segment and has successive series in the exposed sections.Detailed granularity,pollen,geochemical and textural studies reveal the formation processes of Waka debris flows.The age estimates of optically stimulated luminescence(OSL) using SAR protocol show that the occurrence of major debris flows started at around 12.6 ka BP and weakened until 4.5 ka BP in the upper Jinsha River valley.The rich source of weathered detritus,steep landform and concentrated precipitation are the dominant factors causing the occurrence of debris flows in the area.The seasonal variation of the southwest monsoon circulation over the Tibetan Plateau and its adjacent area results in substantial rainfall during summer in the area.Climate change is thus characterized by the alteration between cold-dry and warm-wet.The most characteristic features of Paleoclimatic records are the sudden establishment of wet conditions around 10.0 ka BP,and maximum aridity around 4~3 a BP.Objected to the strengthening of the southwest monsoon in the SE margin of the Tibetan Plateau in the early Holocene,the climate in the dry-hot valley trended to be wetter and the rainfall in the summer seasons might increased.The age estimates of optically stimulated luminescence show that the occurrence of major debris flows corresponded to the obvious strengthened phase of the summer monsoons in the region.The formation characteristics and ages of the debris-flow deposits in the upper Jinsha river indicates that the occurrence of a mass of debris flows were a response to the intensified southwest monsoon in the southeast margin of the Tibetan Plateau since the early Holocene.",
        "keywords": [
            "southwest monsoon",
            "Jinsha River",
            "climatic change",
            "dry valley",
            "debris flow"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": "School of Engineering and Technology,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "CUI Zhijiu",
                "org": "Urban and Environmental Department,Beijing University,Beijing ,China"
            },
            {
                "name": "Dai Fuchu",
                "org": "Division of Tibet Plateau,Institute of Geology and Geophysics,CAS,Beijing ,China"
            },
            {
                "name": "XU Chong",
                "org": "Division of Tibet Plateau,Institute of Geology and Geophysics,CAS,Beijing ,China"
            }
        ],
        "venue": "Journal of Mountain Science",
        "year": 2011
    },
    "Cfl3LPej": {
        "id": "Cfl3LPej",
        "title": "Study on the Training Mode of the Inter-disciplinary Talents of Geoengineering Major",
        "abstract": "In this paper,the history and current situation of the geoengineering major is introduced.For purposes of adapting the development and talent necessity under the socialist market economic,the authors suggest strengthening the train mode of the inter-disciplinary talent of the geoengineering major,it means that the students not only have the knowledge of geologic investigation,but also know how to make the engineering design.To realizing the training mode of geoengineering major,we should attach great importance to the curriculum,practice teaching and teaching program and improve the quality of the teachers,practice base and laboratory establishment.",
        "keywords": [
            "geoengineering",
            "training mode",
            "inter-disciplinary talent"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": " China University of Geosciences,Beijing ,China"
            },
            {
                "name": "SHEN Nai-qi",
                "org": " China University of Geosciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Geological Education",
        "year": 2011
    },
    "9VJF3J6m": {
        "id": "9VJF3J6m",
        "title": "Investigation on Occupation Orientation and Career Planning of University Students Majoring in Civil Engineering in China University of Geosciences(Beijing)",
        "abstract": "In recent years,the population of university students for employment has increased rapidly,while the economic speed in China appears to be decreasing.The problem of the undergraduate's working career become more serious.Based on the study of undergraduates' occupation orientation in China University of Geosciences,self-cognization,career planning degree and other relative factors,this paper analyzes universtiy students' view on employment and career plan and put forwards some proposals on how to guide university students to form their career plan and select the employment correctly.",
        "keywords": [
            "civil engineering",
            "occupation orientation",
            "career plan"
        ],
        "authors": [
            {
                "name": "CHEN Jian",
                "org": " China University of Geosciences,Beijing ,China"
            },
            {
                "name": "ZHANG Ye",
                "org": " China University of Geosciences,Beijing ,China"
            },
            {
                "name": "WANG Cong",
                "org": " China University of Geosciences,Beijing ,China"
            },
            {
                "name": "ZHANG Lei",
                "org": " China University of Geosciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Geological Education",
        "year": 2011
    },
    "Cqjf9EZR": {
        "id": "Cqjf9EZR",
        "title": "GIS BASED CERTAINTY FACTOR ANALYSIS OF LANDSLIDE TRIGGERING FACTORS IN WENCHUAN EARTHQUAKE",
        "abstract": "On May 12,2008 at 14:28(local time),a catastrophic earthquake with surface wave magnitude of 8.0 struck the Sichuan Province of China.Tens of thousands of landslides were triggered by this earthquake over a broad area.48 007 landslides were interpreted from aerial photographs and multi-source remote sensing imageries,and they are verified by field investigation.Based on the interpretation results,landslide triggering factors with certainty analysis is carried out by means of GIS spatial analysis.The 12 impact factors contributing to the Wenchuan earthquake-induced landslide occurrences include stratigraphic,lithology,main faults,seismic intensity,macroscopic epicenter,surface rupture points,slope gradient,aspect,profile curvature,elevation,drainages,and roads.The certainty factor analysis result shows that five categories of high landslide susceptibility value are as follows:(1) stratigraphic of Cambrian,Ordovician,Permian and Carboniferous,lithology of intrusive rock group and limestone rock group;(2) Wenchuan earthquake-induced landslides are most affected by the main central fault,and also controlled by the Qianshan fault,the little impact for Houshan fault;(3) there are correlations between landslide susceptibility and seismic intensity,distance from the epicenter and surface rupture zone;(4) slope gradient of more than 40\u00b0,aspects of east and southeast directions,elevations between 1 000 m and 2 000 m,especial between 1 000 m and 1 500 m were susceptible for landslide occurrence;and (5) distance to drainages is less than 400 m and less than 2 000 m away from roads.The results show that the numerical intervals of each factor are inclined to landslides.This work is the basement for further study of earthquake-induced landslides hazard evaluation and prediction.",
        "keywords": [
            "spatial analysis",
            "Wenchuan earthquake",
            "certainty factor",
            "earthquake-induced landslide",
            "slope engineering"
        ],
        "authors": [
            {
                "name": "XU Chong",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "DAI Fuchu",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "YAO Xin",
                "org": "Institute of Geomechanics,Chinese Academy of Geological Sciences,Beijing ,China;Key Laboratory of Neotectonic and Geohazard,Ministry of Land and Resources,Beijing ,China"
            },
            {
                "name": "CHEN Jian",
                "org": "China University of Geosciences,Beijing ,China"
            },
            {
                "name": "TU Xinbin",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "CAO Yanbo",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "XIAO Jianzhang",
                "org": "Institute of Geology and Geophysics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Rock Mechanics and Engineering",
        "year": 2010
    },
    "LF12jlbw": {
        "id": "LF12jlbw",
        "title": "Preliminary Research on the Relationship Between Microscopic Structure and Shear Strength of Red-bed Soft Rocks",
        "abstract": "Red-bed soft rocks belong to the layers which are susceptible to landslide and collapse.The micro-structural characteristics of the rock have an important impact on its macroscopic mechanical strength.In this paper,the micro-structural observation with scanning electron microscopy(SEM) and the angle-changed shear strength test of the Jurassic red-bed sandstone,siltstone and mudstone samples which were collected from Pingshan County in Sichuan Province and Suijiang County in Yunnan Province were conducted.A large number of microstructures of red-bed sandstone,siltstone and mudstone were analyzed and the shear strength values of the red-bed soft rocks were obtained.The microstructure parameters,i.e.porosity,particle roundness,particle orientation and the quantized value of Euler number of the red-bed sandstone,siltstone and mudstone were extracted based on MATLAB digital image processing techniques.Then the quantitative relationship between the above parameters and the shear strength were analyzed.The results show that the shear strength and porosity of the red-bed soft rock have a negative exponential relationship;the shear strength and particle roundness and particle orientation have a negative linear relationship;the shear strength and the Euler number have positively correlated linear relationship.",
        "keywords": [
            "shear strength",
            "digital image",
            "microstructure",
            "red-bed soft rock",
            "correlation"
        ],
        "authors": [
            {
                "name": "WANG Ying-chun",
                "org": "School of Engineering and Technology,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "CHEN Jian",
                "org": "School of Engineering and Technology,China University of Geosciences,Beijing ,China"
            }
        ],
        "venue": "Geoscience",
        "year": 2013
    },
    "7wlH4uom": {
        "authors": [
            {
                "name": "A.F. Jalbout",
                "org": "NASA Astrobiology Centers Program"
            },
            {
                "name": "Z. Zhou",
                "org": "State Key Laboratory"
            },
            {
                "name": "X.H. Li",
                "org": "NASA Astrobiology Centers Program"
            },
            {
                "name": "Y. Shi",
                "org": "State Key Laboratory"
            },
            {
                "name": "A. Kosmas",
                "org": "Department of Chemistry"
            }
        ],
        "title": "The self-reaction of methylperoxy radicals: A theoretical study",
        "abstract": "The global potential energy surfaces of the (CH",
        "keywords": [
            ""
        ],
        "venue": "Chemical Physics Letters",
        "year": 2006,
        "id": "7wlH4uom"
    },
    "0YzTJhot": {
        "authors": [
            {
                "name": "J. Lu",
                "org": "State Key Laboratory of Crystal Materials"
            },
            {
                "name": "A.F. Jalbout",
                "org": "Department of Chemistry"
            },
            {
                "name": "Z. Zhou",
                "org": "State Key Laboratory of Crystal Materials"
            }
        ],
        "title": "Covalent anion of Li(HF)3 - system. An ab initio study",
        "abstract": "In this paper, we report the stability of the Li(HF)",
        "keywords": [
            "Ab initio",
            "Covalent anion",
            "Electron affinity",
            "Li systems",
            "Vertical detachment energy"
        ],
        "venue": "Ecletica Quimica",
        "year": 2007,
        "id": "0YzTJhot"
    },
    "tzwKlhIY": {
        "id": "tzwKlhIY",
        "title": "Effects of epimedium on inflammatory factor of type 2 diabetic mellitus rats",
        "authors": [
            {
                "name": "SHANG Yong-fang",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "XU Qian",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "WANG Hui-ling",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "YAO Min-xiu",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "LI Ying",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "XU Ai-mei",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "ZHANG Fang-hua",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            },
            {
                "name": "GAO Shan",
                "org": "The Central Hospital of Qingdao,Qingdao ,China"
            }
        ],
        "venue": "proceeding of clinical medicine",
        "keywords": [
            "epimedium",
            "inflammatory factor",
            "rats",
            "type 2 diabetes"
        ],
        "year": 2012
    },
    "XaEEw798": {
        "id": "XaEEw798",
        "title": "SustainabilityEvaluation of the General Land Use Planning Based on the Marginal Effect of Construction Land Expansion:ACase Studyof Jiangsu Province",
        "authors": [
            {
                "name": "XU Hui",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China;Department of Geography,College of Tourism,Shanghai Normal University,Shanghai ,China"
            },
            {
                "name": "HUANG Xianjin",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "ZHAO Rongqin",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "LI Ying",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "resources science",
        "keywords": [
            "Marginal effect",
            "Land use general planning",
            "Construction land expansion",
            "Sustainability evaluation",
            "Jiangsu Province"
        ],
        "year": 2010
    },
    "OvwIjs77": {
        "id": "OvwIjs77",
        "title": "Progress in the Research of Carbon Cycle and Management of Urban System",
        "authors": [
            {
                "name": "ZHAO Rong-qin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China;College of Resources and Environment,North China Institute of Water Conservancy and Hydroelectric Power,Zhengzhou ,China"
            },
            {
                "name": "HUANG Xian-jin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "XU Hui",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "GAO Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "journal of natural resources",
        "keywords": [
            "modeling",
            "carbon management",
            "carbon flux",
            "carbon cycle",
            "urban system",
            "decarbonization"
        ],
        "year": 2009
    },
    "Ffae0BKo": {
        "id": "Ffae0BKo",
        "title": "Study on the Emergy Analysis and Efficiency and Sustainability Evaluation of the Coastal Region Cultivated Land System in Jiangsu Province",
        "authors": [
            {
                "name": "XU Hui",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China;Department of Geography,College of Tourism,Shanghai Normal University,Shanghai ,China"
            },
            {
                "name": "HUANG Xian-jin",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "ZHAO Rong-qin",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "journal of natural resources",
        "keywords": [
            "efficiency and sustainability evaluation",
            "coastal region of Jiangsu Province",
            "emergy analysis",
            "cultivated land eco-economic system"
        ],
        "year": 2011
    },
    "VKf0x5xR": {
        "id": "VKf0x5xR",
        "title": "Regional Carbon Emission Inventory Estmimation and Reduction Potential Analysis in Jiangsu Province",
        "authors": [
            {
                "name": "Zhao Rongqin",
                "org": "College of Resources and Environment,North China University of Water Conservancy and Hydroelectric Power,Zhengzhou , China;School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Huang Xianjin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Gao Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Zhao Zhiling",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "areal research and development",
        "keywords": [
            "estimation",
            "carbon reduction",
            "carbon emission",
            "potential",
            "Jiangsu Province"
        ],
        "year": 2013
    },
    "77wcilA2": {
        "id": "77wcilA2",
        "title": "Analysis on the Changing Dynamics of the Pattern of Planning Overall Cities and Countrysides in Jiangsu Province",
        "authors": [
            {
                "name": "WU Yong-sheng",
                "org": "College of Humanities & Social Sciences,China Jiliang University,Hangzhou ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Institute of Rural Economy,Academy of Social Sciences in Jiangsu Province,Nanjing ,China"
            },
            {
                "name": "YANG Chen",
                "org": "College of Humanities & Social Sciences,China Jiliang University,Hangzhou ,China"
            }
        ],
        "venue": "areal research and development",
        "keywords": [
            "spatial structure",
            "Jiangsu Province",
            "planning overall cities and countrysides"
        ],
        "year": 2007
    },
    "xiHozAG9": {
        "id": "xiHozAG9",
        "title": "Inspiration from urban water pollution governance in the developed countries",
        "authors": [
            {
                "name": "GAO Shan"
            },
            {
                "name": "HUANG Xian-jin"
            }
        ],
        "venue": "urban problems",
        "keywords": [
            "inspiration",
            "urban water pollution control",
            "the developed countries",
            "comparison"
        ],
        "year": 2011
    },
    "J3mMDMCG": {
        "id": "J3mMDMCG",
        "title": "INDEX SYSTEM ON PERFORMANCE EVALUATION OF ECOLOGICAL CIVILIZATION IN PROVINCE ADMINISTRATIVE AREAS\u2014\u2014A CASE IN JIANGSU PROVINCE",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,Jiangsu,China;Jiangsu Academy of Social Sciences,Nanjing ,Jiangsu,China"
            },
            {
                "name": "HUANG Xian-jin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,Jiangsu,China"
            }
        ],
        "venue": "economic geography",
        "keywords": [
            "Jiangsu province",
            "ecological civilization",
            "performance evaluation",
            "the index system"
        ],
        "year": 2010
    },
    "bAH5dIy8": {
        "id": "bAH5dIy8",
        "title": "Performance Evaluation of Eco-construction Based on PSR Model in China from 1953 to 2008",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China;Rural Development Institute,Jiangsu Academy of Social Sciences,Nanjing ,China"
            },
            {
                "name": "HUANG Xian-jin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "journal of natural resources",
        "keywords": [
            "PSR model",
            "eco-environment quality",
            "administrative decision",
            "performance evaluation of eco-construction",
            "China"
        ],
        "year": 2010
    },
    "mzhT18ip": {
        "id": "mzhT18ip",
        "title": "INFLUENCE OF RURAL MARKETIZATION ON FARMERS' CULTIVATED LAND TRANSFER:AN EMPIRICAL STUDY BASED ON SHANGHAI CITY,JIANGSU AND ANHUI PROVINCE",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China;Rural Development Institute,Jiangsu Academy of Social Sciences,Nanjing ,China"
            },
            {
                "name": "HUANG Xian-jin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "resources and environment in the yangtze basin",
        "keywords": [
            "Heckman model",
            "cultivated land transfer",
            "agricultural product sale",
            "rural marketization",
            "rural households"
        ],
        "year": 2012
    },
    "M0IGm29e": {
        "id": "M0IGm29e",
        "title": "Evaluation Index System of Green Nanjing City Construction",
        "authors": [
            {
                "name": "Wang Wanjing",
                "org": "School of Geographic & Oceanic Science,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Zhao Rongqin",
                "org": "School of Geographic & Oceanic Science,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Chuai Xiaowei",
                "org": "School of Geographic & Oceanic Science,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Gao Shan",
                "org": "Jiangsu Academy of Social Sciences,Nanjing ,China"
            }
        ],
        "venue": "areal research and development",
        "keywords": [
            "green Nanjing",
            "city construction",
            "evaluation index system"
        ],
        "year": 2012
    },
    "u0N6jKQK": {
        "id": "u0N6jKQK",
        "title": "Evaluation on Intensive Land Use of Electric Power Industry in Jiangyin City",
        "authors": [
            {
                "name": "XU Hui",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China;College of Tourism,Shanghai Normal University,Shanghai ,China"
            },
            {
                "name": "HUANG Xian-jin",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "YAO Li",
                "org": "China Land Surveying and Planning Institute,Beijing ,China"
            },
            {
                "name": "CHUAI Xiao-wei",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "ZHAO Rong-qin",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Department of Land Resources and Tourism Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "china land science",
        "keywords": [
            "Jiangyin City",
            "electric power industry",
            "intensive land use",
            "evaluation"
        ],
        "year": 2010
    },
    "qpMVBihc": {
        "id": "qpMVBihc",
        "title": "Research on Connotation of Ecological Civilization",
        "authors": [
            {
                "name": "GAO Shan",
                "org": " School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China; Rural Development Institute,Jiangsu Academy of Social Sciences,Nanjing ,China"
            },
            {
                "name": "HUANG Xianjin",
                "org": " School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "ecological economy",
        "keywords": [
            "connotation",
            "ecological ethics",
            "ecological civilization"
        ],
        "year": 2009
    },
    "0QPMSljA": {
        "id": "0QPMSljA",
        "title": "Influence of agricultural marketization on farmers' planting benefit: An empirical study of Shanghai, Jiangsu and Anhui",
        "abstract": "With the progressive development of market economy,agricultural marketization enters into a new stage in China,and its relation to the rural land use change becomes closer and closer.In order to analyze the relationship between agricultural marketization and farmers' planting benefit,this paper used Shanghai Municipality,Jiangsu and Anhui provinces as research cases.Anhui was the representative of a traditional rural region,while Shanghai and Jiangsu were representatives of the developed regions in the Yangtze River Delta.A total of 1058 valid questionnaires in 16 villages of five counties were carried out during July-April 2010.The results showed that more sufficient market competition was beneficial to maximization of productive profits of farmers.The profit rate of cash crops was higher than that of food crops.There were obvious regional differences in investigated areas.According to quantitative analysis and expanded CD model test,the rural households' planting benefit was remarkable due to the affects of the markets of production factors and agricultural products.Firstly,for the purpose of obtaining the higher output,the rural households preferred to increase the input of material goods that were mainly composed of seed,pesticide and fertilizer.The inputs of labor force and agricultural machine were changed with rural households' non-agricultural behaviors.In detail,agricultural production had to follow respective productive characteristics.The rural households,whose income was chiefly depended on agricultural activity,tended to increase yield-increasing capital input and manpower input.The rural households,whose income was chiefly depended on non-agricultural activity,tended to increase labor-saving capital input and reduce manpower input.Secondly,the sale behaviors of agricultural products had positive stimulation to enlarge the planting benefit.The price of agricultural products is one of the key factors that affected farmland profits.The price of agricultural means would be fluctuated by the change of price of agricultural products.The sales rate and the selling costs of agricultural products had stronger impact on the benefit of market-oriented agriculture products than that of self-supporting ones.The rise of sales rate and selling costs played an active role in the increase of output value of agricultural products.Thirdly,rural households' education and income structure had significant effects on the planting benefit.There was a positive correlation between farmers' planting benefit and the human capital.",
        "keywords": [
            "planting benefit",
            "production factors",
            "sale of agricultural product",
            "agricultural marketization",
            "expanded CD model"
        ],
        "authors": [
            {
                "name": "GAO Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China;Rural Development Institute,Jiangsu Academy of Social Sciences,Nanjing ,China"
            },
            {
                "name": "HUANG Xianjin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "ZHONG Taiyang",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "CHEN Zhigang",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "Geographical Research",
        "year": 2013
    },
    "KKsDjwAc": {
        "id": "KKsDjwAc",
        "title": "Research on Development Patterns of Circular Economy in Major Function Oriented Zoning",
        "authors": [
            {
                "name": "Gao Shan",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China;Rural Development Institute,Jiangsu Academy of Social Sciences,Nanjing ,China"
            },
            {
                "name": "Huang Xianjin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Zhao Rongqin",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            },
            {
                "name": "Xu Hui",
                "org": "School of Geographic and Oceanographic Sciences,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "areal research and development",
        "keywords": [
            "circular economy",
            "major function oriented zoning",
            "development patterns"
        ],
        "year": 2011
    },
    "2wStICk0": {
        "authors": [
            {
                "name": "Zhaowei Wang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Yang Qiu",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Yongxiang Liu",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Nan Qi",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Jie Si",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Xiaoling Xia",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Di Wu",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Yuanyang Hu",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Xi Zhou",
                "org": "State Key Laboratory of Virology"
            }
        ],
        "title": "Characterization of a nodavirus replicase revealed a de novo initiation mechanism of RNA synthesis and terminal nucleotidyltransferase activity",
        "abstract": "Nodaviruses are a family of positive-stranded RNA viruses with a bipartite genome of RNAs. In nodaviruses, genomic RNA1 encodes protein A, which is recognized as an RNA-dependent RNA polymerase (RdRP) and functions as the sole viral replicase protein responsible for its RNA replication. Although nodaviral RNA replication has been studied in considerable detail, and nodaviruses are well recognized models for investigating viral RNA replication, the mechanism(s) governing the initiation of nodaviralRNAsynthesis have not been determined. In this study, we characterized the RdRP activity of Wuhan nodavirus (WhNV) protein A in detail and determined that this nodaviral protein A initiates RNA synthesis via a de novo mechanism, and this RNA synthesis initiation could be independent of other viral or cellular factors. Moreover, we uncovered that WhNV protein A contains a terminal nucleotidyltransferase (TNTase) activity, which is the first time such an activity has been identified in nodaviruses. We subsequently found that the TNTase activity could function in vitro to repair the 3' initiation site, which may be digested by cellular exonucleases, to ensure the efficiency and accuracy of viral RNA synthesis initiation. Furthermore, we determined the cis-acting elements for RdRP or TNTase activity at the 3'-end of positive or negative strand RNA1. Taken together, our data establish the de novo synthesis initiation mechanism and the TNTase activity of WhNV protein A, and this work represents an important advance toward understanding the mechanism(s) of nodaviral RNA replication. \u00a9 2013 by The American Society for Biochemistry and Molecular Biology, Inc.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Biological Chemistry",
        "year": 2013,
        "id": "2wStICk0"
    },
    "RfAgIgNA": {
        "authors": [
            {
                "name": "Rui Chen",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Rui Jin",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Lu Wu",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Xiaofei Ye",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Yi Yang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Kan Luo",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Wenxi Wang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Di Wu",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Xing Ye",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Liqin Huang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Tao Huang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Gengfu Xiao",
                "org": "State Key Laboratory of Virology"
            }
        ],
        "title": "Reticulon 3 attenuates the clearance of cytosolic prion aggregates by inhibiting autophagy",
        "abstract": "Autophagy plays an important role in targeting cellular proteins, protein aggregates and organelles for degradation for cell survival. Autophagy dysfunction has been extensively described in neurodegenerative conditions linked to protein misfolding and aggregation. However, the role of autophagy in the prion disease process is unclear. Here, we show that when expressed in mouse neuroblastoma N2a cells, cytoplasmic PrP (cyPrP) aggregates lead to endoplasmic reticulum stress (ER stress), activation of reticulon 3 (RTN3), impairment of ubiquitin-proteasome system (UPS), induction of autophagy and apoptosis. RTN3 belongs to the reticulon family with the highest expression in the brain and RTN3 is often activated under ER stress. To assess the function of RTN3 in pathological conditions involving cyPrP protein misfolding, we knocked down the expression of RTN3 in cyPrP-transfected cells; unexpectedly, the inhibition of expression of RTN3 enhances the induction of autophagy resulted from cyPrP aggregates, and the process is mediated by the enhanced interaction between Bcl-2 and Beclin 1 promoted by RTN3, which enhances Bcl-2-mediated inhibition of Beclin 1-dependent autophagy. Furthermore, downregulation of RTN3 promoted the clearance of cyPrP aggregates, allowed the activity of the UPS to resume, and alleviated ER stress; ultimately, apoptosis due to the cyPrP aggregates was inhibited. Together, these data suggest that RTN3 negatively regulates autophagy to block the clearance of cyPrP aggregates and provide a clue regarding the potential to induce autophagy for the treatment of prion disease and other neurodegenerative diseases such as Parkinson disease (PD), Alzheimer disease (AD) and Huntington disease (HD). \u00a9 2011 Landes Bioscience.",
        "keywords": [
            "Apoptosis",
            "Autophagy",
            "Er stress",
            "Prion",
            "RTN3",
            "UPS"
        ],
        "venue": "Autophagy",
        "year": 2011,
        "id": "RfAgIgNA"
    },
    "nNfxOV0b": {
        "authors": [
            {
                "name": "Wenxi Wang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Rui Chen",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Kan Luo",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Di Wu",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Liqin Huang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Tao Huang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Gengfu Xiao",
                "org": "State Key Laboratory of Virology"
            }
        ],
        "title": "Calnexin inhibits thermal aggregation and neurotoxicity of prion protein",
        "abstract": "Prion diseases are fatal neurodegenerative disorder associated with the conversion of the cellular isoform of the prion protein (PrP",
        "keywords": [
            "Apoptosis",
            "Calnexin",
            "Cytotoxicity",
            "Molecular chaperone",
            "Prion"
        ],
        "venue": "Journal of Cellular Biochemistry",
        "year": 2010,
        "id": "nNfxOV0b"
    },
    "cxMhWYvc": {
        "authors": [
            {
                "name": "Chen Chen",
                "org": ""
            },
            {
                "name": "Di Wu",
                "org": ""
            },
            {
                "name": "Leike Zhang",
                "org": ""
            },
            {
                "name": "Yong Zhao",
                "org": ""
            },
            {
                "name": "Lin Guo",
                "org": ""
            }
        ],
        "title": "Comparative phosphoproteomics studies of macrophage response to bacterial virulence effectors",
        "abstract": "Lipopolysaccharide (LPS) from Gram-negative bacteria and cell wall components from Gram-positive bacteria are pathogenic inducers of host cell innate immune systems. In this study, we adapted stable isotope labeling with amino acid in cell culture (SILAC) and Fe",
        "keywords": [
            "LPS",
            "Macrophage",
            "Phosphoproteomics",
            "TLR"
        ],
        "venue": "Journal of Proteomics",
        "year": 2012,
        "id": "cxMhWYvc"
    },
    "P5XmMbWH": {
        "authors": [
            {
                "name": "Di Wu",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Wentao Zhang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Qingying Luo",
                "org": "College of Chemistry and Molecular Science"
            },
            {
                "name": "Kan Luo",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Liqin Huang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Wenxi Wang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Tao Huang",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Rui Chen",
                "org": "State Key Laboratory of Virology and Modern Virology Research Centre"
            },
            {
                "name": "Yi Lin",
                "org": "College of Chemistry and Molecular Science"
            },
            {
                "name": "Daiwen Pang",
                "org": "College of Chemistry and Molecular Science"
            },
            {
                "name": "Gengfu Xiao",
                "org": "State Key Laboratory of Virology"
            }
        ],
        "title": "Copper (II) promotes the formation of soluble neurotoxic PrP oligomers in acidic environment",
        "abstract": "Prion diseases are classically considered to be \"amyloid diseases\" caused by the deposition of amyloid fibrils in the brain. Recent studies identified soluble oligomers of PrP (prion protein) in damaged neuronal tissue. However, the details of PrP oligomerization are still unclear. In this study, we demonstrate that Cu",
        "keywords": [
            "Acidic Ph",
            "Copper",
            "Oligomer",
            "Prion",
            "Toxicity"
        ],
        "venue": "Journal of Cellular Biochemistry",
        "year": 2010,
        "id": "P5XmMbWH"
    },
    "lG9MmKxH": {
        "authors": [
            {
                "name": "Liqin Huang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Rui Jin",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Jiarui Li",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Kan Luo",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Tao Huang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Di Wu",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Wenxi Wang",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Rui Chen",
                "org": "State Key Laboratory of Virology"
            },
            {
                "name": "Gengfu Xiao",
                "org": "State Key Laboratory of Virology"
            }
        ],
        "title": "Macromolecular crowding converts the human recombinant PrP",
        "abstract": "Prion diseases are fatal neurodegenerative disorders and are linked with the conversion of the cellular isoform of the prion protein (PrP",
        "keywords": [
            "Crowded environment",
            "Neurotoxicity",
            "Oligomerization",
            "Prion protein",
            "Thermodynamic stability"
        ],
        "venue": "FASEB Journal",
        "year": 2010,
        "id": "lG9MmKxH"
    },
    "jjl3P10U": {
        "id": "jjl3P10U",
        "title": "A Comparative Study on the Antioxidant Properties of Ethanol Extract and Its Different Polarity Fractions from the Bulb of Lilium lancifolium Thunb",
        "authors": [
            {
                "name": "ZHOU Zhong-liu",
                "org": "School of Chemistry Science and Technology,Zhanjiang Normal University,Zhanjiang ,China;School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China;Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education,College of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "food science",
        "keywords": [
            "antioxidant activity",
            "Lilium lancifolium Thunb.",
            "bioactive fractions",
            "free radical scavenging activity"
        ],
        "year": 2011
    },
    "42EO7RVK": {
        "id": "42EO7RVK",
        "title": "Monoterpenes of Paeonia lactiflora Pall",
        "authors": [
            {
                "name": "WANG Yan-zhi",
                "org": "School of Pharmacy,Henan College of Traditional Chinese Medicine,Zhengzhou ,China;College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "FENG Wei-sheng",
                "org": "School of Pharmacy,Henan College of Traditional Chinese Medicine,Zhengzhou ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "JIANG Yan-yan",
                "org": "College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese pharmaceutical journal",
        "keywords": [
            "chemical constituents",
            "monoterpene",
            "Paeonia lactiflora Pall."
        ],
        "year": 2008
    },
    "62JNvm7T": {
        "id": "62JNvm7T",
        "title": "HPLC characteristic spectrum of aqueous extracts from Bohe (Herba Menthae)",
        "authors": [
            {
                "name": "WANG Yue-ming",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "JIANG Yan-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "characteristic spectrum",
            "aqueous extracts",
            "Bohe(Herba Menthae)"
        ],
        "year": 2010
    },
    "GyVWWmED": {
        "id": "GyVWWmED",
        "title": "Quantitative determination of three steroidal saponins in effective fraction of Juandan (Lilium lancifolium Thunb.) by HPLC",
        "authors": [
            {
                "name": "ZHOU Zhong-liu",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "Juandan (Lilium lancifolium Thunb.)",
            "steroidal saponins",
            "quantitative determination"
        ],
        "year": 2010
    },
    "jT4MO4fo": {
        "id": "jT4MO4fo",
        "title": "HPLC fingerprint of flavonoids of Kushen Tang and its correlation to Scutellaria baicalensis and Sophora flavescens]",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHU Li-jun",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "fingerprint",
            "scutellaria baicalensis",
            "kushen tang",
            "flavonoids",
            "sophora flavescens"
        ],
        "year": 2007
    },
    "7jYipQna": {
        "id": "7jYipQna",
        "title": "Quantitative determination of multi-index constituents based on HPLC fingerprint chromatogram of effective fraction of Jiangzhining with actions of lipid regulation and anti-oxidation",
        "authors": [
            {
                "name": "LUO Wen",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "3",
            "2",
            "4'-tetrahydroxy-stilbene-2-O-\u03b2-D-glucoside",
            "5",
            "fingerprint chromatogram",
            "Jiangzhining",
            "quantitative determination"
        ],
        "year": 2010
    },
    "2Ww0IcLc": {
        "id": "2Ww0IcLc",
        "title": "Quantitative determination of ginsenoside Rg_1,ginsenoside Rb_1 and notoginsenoside R_1 in effective fraction of Qingnaoxuanqiao Formula by HPLC",
        "authors": [
            {
                "name": "CHEN Yu-ping",
                "org": "School of Chinese pharmacy,Beijing University of Chinese Medcine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese pharmacy,Beijing University of Chinese Medcine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese pharmacy,Beijing University of Chinese Medcine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "ginsenoside Rb1",
            "Qingnaoxuanqiao Formula",
            "notoginsenoside R1",
            "high performance liquid chromatography",
            "ginsenoside Rg1",
            "quantitative determination"
        ],
        "year": 2007
    },
    "3OsN7IZT": {
        "id": "3OsN7IZT",
        "title": "Construction and Development of Chinese Medicine Chemistry Elite Course in Chinese Pharmaceutical Speciality",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Renbing",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHANG Guiyan",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "GUO Yajian",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "pharmaceutical education",
        "keywords": [
            "Course construction",
            "Chinese Medicine Chemistry",
            "Education reform",
            "Elite course"
        ],
        "year": 2006
    },
    "sqXcr68a": {
        "id": "sqXcr68a",
        "title": "Study on chemical Components of Acorus Tatarinowii(\u2161)",
        "authors": [
            {
                "name": "Dong Yu",
                "org": "Nei Menggu Medical College,Huhehaote,Nei Menggu,China "
            },
            {
                "name": "Shi Renbing",
                "org": "Beijing University of Chinese Medicine,Beijing,China "
            },
            {
                "name": "Liu Bin",
                "org": "Beijing University of Chinese Medicine,Beijing,China "
            }
        ],
        "venue": "china pharmaceuticals",
        "keywords": [
            "non- volatilis fraction",
            "chemical components",
            "Acorus Tatarinowii schott"
        ],
        "year": 2008
    },
    "0667JnTY": {
        "id": "0667JnTY",
        "title": "Content determination of galgravin and veraguensin from effective fraction of A.tatarinowii Schott",
        "authors": [
            {
                "name": "DONG Yu",
                "org": " School of Pharmacy, Neimenggu Medical College,Neimen "
            },
            {
                "name": "SHI Ren-bing",
                "org": " School of Chinese Pharmacy, Beijing University of Chinese Medicine"
            },
            {
                "name": "LIU Bin",
                "org": " School of Chinese Pharmacy, Beijing University of Chinese Medicine"
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "content determination",
            "veraguensin",
            "galgravin",
            "high performance liquid chromatography",
            "effective fraction of A.tatarinowii Schott."
        ],
        "year": 2008
    },
    "KEH6gzyJ": {
        "id": "KEH6gzyJ",
        "title": "Serum pharmacochemistry of Xingnao Gutta Pills(I)",
        "authors": [
            {
                "name": "YANG Chang-ming",
                "org": " School of Mechatronic Engineering, Beijing Institute of Technology, Beijing "
            },
            {
                "name": "CHEN Yu-ping",
                "org": " Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": " Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "LI Xiao",
                "org": " Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "LIU Bin",
                "org": " Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SUN Jian-ning",
                "org": " Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "FENG Chang-gen",
                "org": " School of Mechatronic Engineering, Beijing Institute of Technology, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC fingerprint",
            "rats",
            "serum pharmacochemistry",
            "Xingnao Gutta Pills"
        ],
        "year": 2006
    },
    "Xd3JkNwC": {
        "id": "Xd3JkNwC",
        "title": "Determination of 2,3,5,4'-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside in Beagle Dogs Plasma and Its Pharmacokinetics by RP-HPLC",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "CHEN Yu-ping",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Yu-xia",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese pharmaceutical journal",
        "keywords": [
            "3",
            "2",
            "4'-tetrahydroxystilbene-2-O-\u03b2-D-glucoside",
            "stilbene glycoside",
            "5",
            "Polygonum multiflorum",
            "RP-HPLC",
            "pharmacokinetics"
        ],
        "year": 2008
    },
    "N2cgjKqW": {
        "id": "N2cgjKqW",
        "title": "Chemical Constituents of Essential Oil from Rubus amabilis Extracted by Supercritical CO_2",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Hui",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "DONG Fang",
                "org": "Center of Analysis and Test,Capital Normal University,Beijing ,China"
            },
            {
                "name": "WANG Ying-feng",
                "org": "Center of Analysis and Test,Capital Normal University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of experimental traditional medical formulae",
        "keywords": [
            "chemical constituents",
            "essential oil",
            "CO2-SFE",
            "GC-MS",
            "Rubus amabilis"
        ],
        "year": 2011
    },
    "7RZ6eKI2": {
        "id": "7RZ6eKI2",
        "title": "Study on adscription of plasma effective constituents of Beagle dogs after administrated with the extract of Polygonum multiflorum Thunb",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": "Taishan Medical University, Taian , China;Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "CAO Juan",
                "org": "Taishan Medical University, Taian , China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine, Beijing , China"
            }
        ],
        "venue": "china journal of traditional chinese medicine and pharmacy",
        "keywords": [
            "3",
            "2",
            "Effective constituents",
            "Polygonum multiflorum Thunb",
            "5",
            "HPLC fingerprint",
            "4",
            "-tetrahydroxystilbene-2-O-\u03b2-D-glucoside",
            "Effective substances"
        ],
        "year": 2010
    },
    "ECnZJH0a": {
        "id": "ECnZJH0a",
        "title": "HPLC fingerprint chromatogram of Semen Cassiae",
        "authors": [
            {
                "name": "LUO Wen",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "fingerprint chromatogram",
            "RP-HPLC",
            "Semen Cassiae"
        ],
        "year": 2009
    },
    "ES2NkU7N": {
        "id": "ES2NkU7N",
        "title": "Studies on chemical constituents of flavones from Lobelia chinensis Lour",
        "authors": [
            {
                "name": "JIANG Yan-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Qiu-ying",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "DAI Ying",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "structural identification",
            "chemical constituent",
            "flavanoids",
            "Lobelia chinensis Lour."
        ],
        "year": 2009
    },
    "scLVGg9Y": {
        "id": "scLVGg9Y",
        "title": "Research Overview on Pharmacological Actions and Clinical Applications of Tongxieyaofang",
        "authors": [
            {
                "name": "ZHANG Chen",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHENG Hu-zhan",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of experimental traditional medical formulae",
        "keywords": [
            "anti-inflammation",
            "anti-diarrheal",
            "Tongxieyaofang",
            "irritable bowel syndrome (IBS)",
            "analgesia"
        ],
        "year": 2010
    },
    "corY4EsA": {
        "id": "corY4EsA",
        "title": "Identification of Major Metabolites of 2,3,5,4'-Tetrahydroxystilbene-2-O-\u03b2-D-Glucoside in Beagle Dog Plasma by Liquid Chromatography/ion Trap Mass Spectrometry",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "CHEN Yu-ping",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Yu-xia",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese pharmaceutical journal",
        "keywords": [
            "metabolites",
            "3",
            "2",
            "4'-tetrahydroxystilbene-2-O-\u03b2-D-glucoside",
            "Beagle dog",
            "5",
            "LC/MSn"
        ],
        "year": 2008
    },
    "E9fGQhBB": {
        "id": "E9fGQhBB",
        "title": "HPLC fingerprint of Salvia Miltiorrhiza f. Alba",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": " Taishan Medical College,Taian ,Shandong,China; Beijing University of Chinese Medicine,Beijing,,China"
            },
            {
                "name": "GAO Yun-sheng",
                "org": " Taishan Medical College,Taian ,Shandong,China"
            },
            {
                "name": "LIU Bin",
                "org": " Beijing University of Chinese Medicine,Beijing,,China"
            },
            {
                "name": "WANG Wei",
                "org": " Beijing University of Chinese Medicine,Beijing,,China"
            }
        ],
        "venue": "chinese traditional patent medicine",
        "keywords": [
            "HPLC",
            "chromatogram fingerprint",
            "Salvia miltiorrhiza f. Alba"
        ],
        "year": 2010
    },
    "wYdRbXak": {
        "id": "wYdRbXak",
        "title": "Isolation and structure identification of chemical principles from Paeonia Lactiflora Pall.",
        "authors": [
            {
                "name": "WANG Yan-zhi",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "chemical principles",
            "monoterpenoids",
            "Paeonia Lactiflora Pall."
        ],
        "year": 2006
    },
    "mkA6QejL": {
        "id": "mkA6QejL",
        "title": "HPLC fingerprint chromatogram of Polygonum multiflorum Thunb.",
        "authors": [
            {
                "name": "LUO Wen",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "fingerprint chromatogram",
            "RP-HPLC",
            "Polygonum multiflorum Thunb."
        ],
        "year": 2008
    },
    "kgb98HHZ": {
        "id": "kgb98HHZ",
        "title": "Study on chemical compositions in the spikes of Schizonepetae tenuifolia Briq.",
        "authors": [
            {
                "name": "HU Jun",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "ZHANG Yuan-hu",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "DONG Yu",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "chemical compositions",
            "spikes Schizonepeta tenuifolia Briq.",
            "flavonoids"
        ],
        "year": 2006
    },
    "ZYbff3H7": {
        "id": "ZYbff3H7",
        "title": "Quantitative determination of contents of three components in Brucea javanica by HPLC]",
        "authors": [
            {
                "name": "ZHOU Zhongliu",
                "org": "Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang ,China;School of Chinese Pharmacy Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Renbing",
                "org": "School of Chinese Pharmacy Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZOU Jieming",
                "org": "Guilin Sanjin Pharmaceutical Co.,Ltd.,Guilin ,China)"
            },
            {
                "name": "WANG Lisheng",
                "org": "Guilin Sanjin Pharmaceutical Co.,Ltd.,Guilin ,China)"
            },
            {
                "name": "XIA Jingmin",
                "org": "Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "hplc",
            "quassinoid",
            "brucea javanica",
            "quantitative determination"
        ],
        "year": 2011
    },
    "66Li82Cq": {
        "id": "66Li82Cq",
        "title": "Chemical constituents of Shenshao Xinxin Prescription",
        "authors": [
            {
                "name": "LI Zheng",
                "org": "Beijing Institute for Drug Control,Beijing,"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing,,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing,,China"
            }
        ],
        "venue": "chinese traditional patent medicine",
        "keywords": [
            "daidzein 8-C-Apiosyl(1\u21926) glucoside",
            "isoflavanones",
            "Shenshao Xinxin Prescription"
        ],
        "year": 2009
    },
    "Q7W7bT5k": {
        "id": "Q7W7bT5k",
        "title": "HPLC determination of nor-kurarinone,xanthohumol and kuraridin in Radix Sophorae Flavescentis and its flavonoid fraction",
        "authors": [
            {
                "name": "ZHU Li-jun",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "HPLC",
            "nor-kurarinone",
            "xanthohumol",
            "kuraridin",
            "Radix Sophorae Flavescentis",
            "quantitative determination"
        ],
        "year": 2008
    },
    "AMAvHaTl": {
        "id": "AMAvHaTl",
        "title": "Influence of typhaneoside on proliferation of human umbilical arterial smooth muscle cells",
        "authors": [
            {
                "name": "GUO Shu-zhen",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "vascular smooth muscle cells",
            "proliferation",
            "typhaneoside"
        ],
        "year": 2006
    },
    "v3mRhOKW": {
        "id": "v3mRhOKW",
        "title": "A new chemical component of Pueraria lobata (Willd.) Ohwi]",
        "authors": [
            {
                "name": "WANG Yan-zhi",
                "org": "School of Pharmacy,Henan College of Traditional Chinese Medicine,Zhengzhou ,China;College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "FENG Wei-sheng",
                "org": "School of Pharmacy,Henan College of Traditional Chinese Medicine,Zhengzhou ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "College of Materia Medica,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "yao xue xue bao = acta pharmaceutica sinica",
        "keywords": [
            "chemical constituents",
            "puerarinoid d",
            "pueraria lobata(willd.) ohwi."
        ],
        "year": 2007
    },
    "PHEGXN8f": {
        "id": "PHEGXN8f",
        "title": "Study on chemical compositions of Acorus tatarinowii Schott(\u2160)",
        "authors": [
            {
                "name": "DONG Yu",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "lignanoid poxylignans",
            "Acorus tatarinowii Schott",
            "chemical composition"
        ],
        "year": 2007
    },
    "TvB0kuW2": {
        "id": "TvB0kuW2",
        "title": "Processing methods and composition study of slices and decoction of Rhizoma Chuanxiong characterized by chemical composition fingerprint",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIANG Ji-chun",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "JIANG Yan-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "fingerprint chromatogram",
            "decoction",
            "processing",
            "chemical compositions",
            "Rhizoma Chuanxiong"
        ],
        "year": 2009
    },
    "aK3zWUAl": {
        "id": "aK3zWUAl",
        "title": "Quantitative determination of forsythiaside A in Fructus Forsythiae by RP-HPLC",
        "authors": [
            {
                "name": "JIANG Yan-yan",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese medicine,Beijing "
            },
            {
                "name": "LIU Yang",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese medicine,Beijing "
            },
            {
                "name": "LIANG Zhao-chang",
                "org": " Pharmacy Department,Medical Schoole of Jinggangshan University"
            },
            {
                "name": "WANG Shuai",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "Fructus Forsythiae",
            "forsythiaside A",
            "quantitative determination"
        ],
        "year": 2009
    },
    "FaDDLYRT": {
        "id": "FaDDLYRT",
        "title": "A new aporphine alkaloid in leaves of Nelumbo nucifera",
        "authors": [
            {
                "name": "WU Hao",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese traditional and herbal drugs",
        "keywords": [
            "the leaves of Nelumbo nucifera Gaertn.",
            "alkaloids",
            "nelumnucine"
        ],
        "year": 2010
    },
    "tXW2CSp4": {
        "id": "tXW2CSp4",
        "title": "HPLC Fingerprint of Pollen Typhae",
        "authors": [
            {
                "name": "MA Hong-fei",
                "org": "School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            },
            {
                "name": "ZHOU Jun-ting",
                "org": "School of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            }
        ],
        "venue": "chinese traditional and herbal drugs",
        "keywords": [
            "HPLC",
            "fingerprint",
            "Pollen Typhae",
            "similarity"
        ],
        "year": 2006
    },
    "kvTcQvAE": {
        "id": "kvTcQvAE",
        "title": "Fingerprint of Nelumbinis Folium by HPLC",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": "Taishan Medical College,Taian ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "CAO Juan",
                "org": "Taishan Medical College,Taian ,China"
            },
            {
                "name": "GAO Yun-sheng",
                "org": "Taishan Medical College,Taian ,China"
            },
            {
                "name": "QI Yong-xiu",
                "org": "Taishan Medical College,Taian ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese traditional patent medicine",
        "keywords": [
            "HPLC",
            "fingerprint",
            "Nelumbinis Folium"
        ],
        "year": 2011
    },
    "IfgPGrA5": {
        "id": "IfgPGrA5",
        "title": "Quantitative determination of 4 main components in effective fraction of Qingnaoxuanqiao Formula in beagle dogs plasma by RP-HPLC",
        "authors": [
            {
                "name": "CHEN Yu-ping",
                "org": "School of Chinese Pharmacy, Beijing University of Chinese Medcine, Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy, Beijing University of Chinese Medcine, Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy, Beijing University of Chinese Medcine, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "ginsenoside Rb_1",
            "geniposide",
            "Qingnaoxuanqiao Formula",
            "notoginsenoside R_1",
            "high pressure liquid chromatography(HPLC)",
            "ginsenoside Rg_1",
            "drug concentration in blood",
            "quantitative determination"
        ],
        "year": 2007
    },
    "sryynoEq": {
        "id": "sryynoEq",
        "title": "Studies on the chemical reference substance 2-hydroxy-1-methoxyaporphine of Folium Nelumbinis",
        "authors": [
            {
                "name": "WU Hao",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "HPLC",
            "chemical reference substance",
            "Folium Nelumbinis",
            "2-hydroxy-1-methoxyaporphine",
            "DSC"
        ],
        "year": 2010
    },
    "xy7X3W8j": {
        "id": "xy7X3W8j",
        "title": "Study on chemical components from effective fraction of Qingnaoxuanqiao Formula(II)",
        "authors": [
            {
                "name": "LI Xiao",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "CHEN Yu-ping",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "Qingnaoxuanqiao Formula",
            "chemical components",
            "structure identification"
        ],
        "year": 2006
    },
    "5hg70jok": {
        "id": "5hg70jok",
        "title": "Quantitative determination of\u03b1-asarone and\u03b2-asarone in effective fraction of A. tatarinowii Schott.",
        "authors": [
            {
                "name": "DONG Yu",
                "org": "School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "effective fraction of A. tatarinowii Schott.",
            "\u03b2-asarone",
            "\u03b1-asarone",
            "high performance liquid chromatography",
            "quantitative determination"
        ],
        "year": 2007
    },
    "ce1EAVK9": {
        "id": "ce1EAVK9",
        "title": "Protective effect of effective fraction and active components of Jiangzhining Extractum on lesion of umbilical vein endothelial cells",
        "authors": [
            {
                "name": "YANG Ying",
                "org": " Beijing University of Chinese Medicine,Beijing ; Inner Mongolia Medical College"
            },
            {
                "name": "LIU Bin",
                "org": " Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "BI Li-fu",
                "org": " Inner Mongolia Medical College"
            },
            {
                "name": "WANG Wei",
                "org": " Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "endothelial cells",
            "active components",
            "Jiangzhining Extractum",
            "effective fraction",
            "oxidative lesion"
        ],
        "year": 2009
    },
    "Vg7ju1N9": {
        "id": "Vg7ju1N9",
        "title": "HPLC determination of xanthohumol and kuraridin in Sophora flavescens Ait.and the effective fraction of Kushen decoction",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "CHEN Shuo",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "YIN Ran",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "HPLC",
            "xanthohumol",
            "Kushen decoction",
            "kuraridin",
            "quantitative determination",
            "Sophora flavescens Ait"
        ],
        "year": 2006
    },
    "GEZF3y6r": {
        "id": "GEZF3y6r",
        "title": "Chemical constituents of Juandan(Lilium lancifolium Thunb.)",
        "authors": [
            {
                "name": "ZHOU Zhong-liu",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Xue-mei",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "chemical constitutes",
            "steroidal saponins",
            "Juandan(Lilium lancifolium Thunb)"
        ],
        "year": 2010
    },
    "HKaBXEWy": {
        "id": "HKaBXEWy",
        "title": "GC-MS analysis of the fatty components of pollen Typhae before and after being carbonized]",
        "authors": [
            {
                "name": "MA Hong-fei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHANG Gui-yan",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "MA Chang-hua",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "YU Mi-mi",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "gc-ms",
            "pollen typhae",
            "pollen typhae carbonistatus"
        ],
        "year": 2006
    },
    "AH0bvLc4": {
        "id": "AH0bvLc4",
        "title": "Fingerprint chromatograms of chemical principles of Radix Salviae Miltiorrhizae By HPLC",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SONG Wen-ting",
                "org": "Beijing University of Chinese Medicine, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "qualitative control",
            "fingerprint chromatograms",
            "Radix Salviae Miltiorrhizae"
        ],
        "year": 2006
    },
    "BLX5aeFy": {
        "id": "BLX5aeFy",
        "title": "Effects of Jiangzhining on blood lipid regulation and anti-oxidation in hyperlipidemic rats",
        "authors": [
            {
                "name": "YANG Ying",
                "org": "Beijing University of Chinese Medicine, Beijing,China;Inner Mongolia Medical College, Huhhot ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine, Beijing,China"
            },
            {
                "name": "BI Li-fu",
                "org": "Inner Mongolia Medical College, Huhhot ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine, Beijing,China"
            },
            {
                "name": "QI Qi-ge",
                "org": "Beijing University of Chinese Medicine, Beijing,China;Inner Mongolia Medical College, Huhhot ,China"
            },
            {
                "name": "XIAO Shi-feng",
                "org": "Inner Mongolia Medical College, Huhhot ,China"
            }
        ],
        "venue": "china journal of traditional chinese medicine and pharmacy",
        "keywords": [
            "anti-lipid peroxidation",
            "jiangzhining",
            "hyperlipidemia",
            "nitric oxide",
            "blood lipids"
        ],
        "year": 2009
    },
    "dq8Gw7Yx": {
        "id": "dq8Gw7Yx",
        "title": "Quantitative determination of four components in different samples of Nelumbo nucifera by HPLC",
        "authors": [
            {
                "name": "WU Hao",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Yu-xia",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "nuciferine",
            "Nelumbo nucifera",
            "pronuciferine",
            "roemerine",
            "2-hydroxy-1-methoxyaporphine",
            "quantitative determination"
        ],
        "year": 2008
    },
    "4X3wynmv": {
        "id": "4X3wynmv",
        "title": "Studies on chemical components of Lobelia chinensis]",
        "authors": [
            {
                "name": "JIANG Yanyan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing,China"
            },
            {
                "name": "SHI Renbing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing,China"
            },
            {
                "name": "WANG Qiuying",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing,China"
            },
            {
                "name": "DAI Ying",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "isolation",
            "identification",
            "chemical components",
            "lobelia chinensis"
        ],
        "year": 2009
    },
    "WxWep9hz": {
        "id": "WxWep9hz",
        "title": "Teaching by Virtual Reality in Chinese Medicine Chemistry Elite Course",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Renbing",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of TCM,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "pharmaceutical education",
        "keywords": [
            "Interactive teaching",
            "Virtual reality",
            "Chinese Medicine Chemistry",
            "Elite course"
        ],
        "year": 2008
    },
    "HwUwjsTM": {
        "id": "HwUwjsTM",
        "title": "Identification of Major Metabolites of 2-Hydroxy-1-Methoxyaporphine in Beagle Dogs Plasma by Liquid Chromatography/Ion Trap Mass Spectrometry",
        "authors": [
            {
                "name": "WU Hao",
                "org": "Beijing University of Chinese Medicine,Beijing ,China "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China "
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China "
            }
        ],
        "venue": "chinese pharmaceutical journal",
        "keywords": [
            "metabolites",
            "LC-MSn",
            "Beagle dog",
            "2-hydroxy-1-methoxyaporphine"
        ],
        "year": 2009
    },
    "iIPTbbLA": {
        "id": "iIPTbbLA",
        "title": "Variation of chemical compositions in body fluid of rats after taking decoction of Radix Salviae Miltiorrhizae medicinal slices orally",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SONG Wen-ting",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "basic chemical constituents of effective(substance)",
            "Radix Salviae Miltiorrhizae",
            "variation in vivo",
            "medicinal slices"
        ],
        "year": 2006
    },
    "F3mQjNj1": {
        "id": "F3mQjNj1",
        "title": "Steroidal saponins and phenylic constituents from Lilium lancifolium and their anti-oxidant activities",
        "authors": [
            {
                "name": "ZHOU Zhong-liu",
                "org": "School of Chemistry Science and Technology,Zhanjiang Normal University,Zhanjiang ,China;School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing ,China;Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education,School of Chemistry and Chemical Engineering,Guangxi Normal University,Guilin ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZOU Jie-ming",
                "org": "Guilin Sanjin Pharmaceutical Co.,Ltd.,Guilin ,China"
            },
            {
                "name": "XIA Jing-min",
                "org": "School of Chemistry Science and Technology,Zhanjiang Normal University,Zhanjiang ,China"
            }
        ],
        "venue": "chinese traditional and herbal drugs",
        "keywords": [
            "3",
            "phenylic constituents",
            "Lilium lancifolium Thunb.",
            "4-dihydroxybenzaldehyde",
            "anti-oxidant activities",
            "steroidal saponins"
        ],
        "year": 2011
    },
    "2XNU4Nk0": {
        "id": "2XNU4Nk0",
        "title": "HPLC determination of 2-hydroxy-1-methoxyaporphine, pronuciferine, nuciferine and roemerine in Nelumbo nucifera and its alkaloid fraction]",
        "authors": [
            {
                "name": "WANG Yu-xia",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "2-hydroxy-1-methoxyaporphine",
            "nuciferine",
            "roemerine",
            "quantitative determination",
            "pronuciferine",
            "nelumbo nucifera",
            "hplc"
        ],
        "year": 2008
    },
    "eyW58VP8": {
        "id": "eyW58VP8",
        "title": "Quantitative determination of trifolirhizin in Sophora flavescens Ait. and the effective fraction of Kushen Decoction",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "ZHU Li-jun",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "YIN Ran",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "CHEN S",
                "org": "Beijing University of Chinese Medicine, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "Kushen Decoction",
            "Sophora flavescens Ait.",
            "HPLC",
            "trifolirhizin",
            "effective fraction",
            "quantitative determination"
        ],
        "year": 2006
    },
    "uQNwSivn": {
        "id": "uQNwSivn",
        "title": "Advances in research of chemical constituents and pharmacological activities of monoterpene glucosides",
        "authors": [
            {
                "name": "LIU Juan",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHE Gai-mei",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "JIANG Yan-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "drugs & clinic",
        "keywords": [
            "anti-inflammation",
            "chemical constituent",
            "anticancer",
            "hepatoprotective",
            "monoterpene glucosides"
        ],
        "year": 2010
    },
    "4Rl68u5h": {
        "id": "4Rl68u5h",
        "title": "HPLC Determination of the Contents of Four Components in the Chromone Fraction of Saposhnikovia divaricata (Turcz.) Schischk",
        "authors": [
            {
                "name": "JIANG Yan-yan",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "chromone",
            "Saposhnikovia divaricata(Turcz.) Schischk",
            "quantitative determination"
        ],
        "year": 2006
    },
    "zY8TCVI5": {
        "id": "zY8TCVI5",
        "title": "Quantitative determination of four components in alkaloid fraction of Sophora flavescens Ait.by HPLC",
        "authors": [
            {
                "name": "ZHU Li-jun",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "Sophora flavescens Ait.",
            "HPLC",
            "sophocarpine",
            "oxymatrin",
            "matrine",
            "alkaloid fraction",
            "oxysophocarpine",
            "quantitative determination"
        ],
        "year": 2007
    },
    "385F0Omp": {
        "id": "385F0Omp",
        "title": "HPLC determination of hyperin and isoquercitrin in Nelumbo nucifera Gaertn.of different sources",
        "authors": [
            {
                "name": "YUAN Li-chun",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "HPLC",
            "hyperin",
            "isoquercitrin",
            "Nelumbo nucifera Gaertn."
        ],
        "year": 2010
    },
    "u8Iy5bOa": {
        "id": "u8Iy5bOa",
        "title": "ICP-MS determination of the trace elements in Manubzhithang",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Ying-feng",
                "org": "Capital Normal University,Beijing ,China"
            },
            {
                "name": "SHI Yan-zhi",
                "org": "Capital Normal University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "manubzhithang",
            "ICP-MS",
            "trace element",
            "microwave digestinon"
        ],
        "year": 2010
    },
    "I4X5r4WL": {
        "id": "I4X5r4WL",
        "title": "Influence of different combinations of Sini Powder on decocting quantity of liquiritigen and isoliquiritigenin",
        "authors": [
            {
                "name": "LI Jun",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "JIANG Hua",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "liquiritigen",
            "combinations",
            "content determination",
            "RP-HPLC",
            "Sini Powder",
            "isoliquiritigenin"
        ],
        "year": 2006
    },
    "lEVzzHGJ": {
        "id": "lEVzzHGJ",
        "title": "Isolation and structure identification of chemical constituents from Saposhnikovia divaricata (Turcz.) Schischk]",
        "authors": [
            {
                "name": "JIANG Yan-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "TU Guang-zhong",
                "org": "Beijing Institute of Microchemistry,Beijing ,China"
            }
        ],
        "venue": "yao xue xue bao = acta pharmaceutica sinica",
        "keywords": [
            "fangfengalpyrimidine",
            "chromone",
            "umbelliferae",
            "saposhnikovia divaricata(turcz.) schischk"
        ],
        "year": 2007
    },
    "fxRTPvmL": {
        "id": "fxRTPvmL",
        "title": "Variation of chemical compositions in body fluid of rats after taking decoction of Rhizoma Chuanxiong medicinal slices orally",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "DONG Miao",
                "org": "School of Chinese Pharmacology,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "variation in vivio",
            "Rhizoma Chuanxiong",
            "rats",
            "basic chemical constituents of effective substance",
            "medicinal slices"
        ],
        "year": 2008
    },
    "MPBnkv1p": {
        "id": "MPBnkv1p",
        "title": "Determination of nuciferine in Beagle dog plasma by RP-HPLC and research on its pharmacokinetics",
        "authors": [
            {
                "name": "WANG Yu-xia",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "CHEN Yu-ping",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "nuciferine",
            "Nelumbo nucifera",
            "RP-HPLC",
            "pharmacokinetics"
        ],
        "year": 2008
    },
    "ivTN8UFF": {
        "id": "ivTN8UFF",
        "title": "Studies on thermal stabilities of typhaneoside and isorhamnetin-3-O-neohesperidoside",
        "authors": [
            {
                "name": "MA Hong-fei",
                "org": "College of Chinese Medicines,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "College of Chinese Medicines,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHANG Gui-yan",
                "org": "College of Chinese Medicines,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "College of Chinese Medicines,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "china journal of chinese materia medica",
        "keywords": [
            "isorhamnetin-3-O-neohesperidoside",
            "Pollen Typhae Carbonistatus",
            "typhaneoside",
            "stability"
        ],
        "year": 2007
    },
    "EvCPYbEO": {
        "id": "EvCPYbEO",
        "title": "Quantitative Determination of Quercetin in the Lipid-regulation and anti-Oxidation Effective Fraction of Jiangzhining by HPLC",
        "authors": [
            {
                "name": "XU Dongyan",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "JIANG Yanyan",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of modern applied pharmacy",
        "keywords": [
            "HPLC",
            "quercetin",
            "Jiangzhining",
            "quantitative determination"
        ],
        "year": 2011
    },
    "C6H3V77n": {
        "id": "C6H3V77n",
        "title": "Quantitative determination of 4 anthraquinone constituents in effective fractions of Jiangzhining by HPLC",
        "authors": [
            {
                "name": "XU Dong-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "physcion",
            "Jiangzhining",
            "emodin",
            "chrysophanol",
            "aurantio-obtusifolin",
            "quantitative determination"
        ],
        "year": 2010
    },
    "TG5fOhxe": {
        "id": "TG5fOhxe",
        "title": "Chemical constituents of essential oil from a Tibetan herb-Bibilin(Piper longum L.) extracted by supercritical CO_2 fluid extraction",
        "authors": [
            {
                "name": "LIU Bin",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "DONG Fang",
                "org": " Center of Analysis and Test,Capital Normal University"
            },
            {
                "name": "WANG Ying-feng",
                "org": " Center of Analysis and Test,Capital Normal University"
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "chemical constituents",
            "essential oil",
            "Bibilin(Piper longum L.)",
            "gas chromatography-mass spectrometry"
        ],
        "year": 2011
    },
    "JMEIbyRm": {
        "id": "JMEIbyRm",
        "title": "Study on adscription of drug constituents in Beagle dog plasma after intragastric administration with Jiangzhining extract]",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "hplc",
            "effective constituents",
            "jiangzhining extract"
        ],
        "year": 2008
    },
    "ycG83UdR": {
        "id": "ycG83UdR",
        "title": "HPLC Determination of Contents of Four Flavonoids in Different Samples of Sophora flavescens Ait.in the Market",
        "authors": [
            {
                "name": "XU Chao",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "ZHU Lijun",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Renbing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "traditional chinese drug research & clinical pharmacology",
        "keywords": [
            "HPLC",
            "Xanthonumal",
            "Sophoraflavescens Ait.",
            "Determination",
            "Kuraridin",
            "Nor-kurarinone",
            "Trifolirhizin"
        ],
        "year": 2008
    },
    "Momwsd4z": {
        "id": "Momwsd4z",
        "title": "Research on quality control method of stilbene fraction of Polygonum multiflorum Thunb",
        "authors": [
            {
                "name": "WANG Yu-xia",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "WANG Wei",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine, Beijing , China"
            }
        ],
        "venue": "china journal of traditional chinese medicine and pharmacy",
        "keywords": [
            "3",
            "2",
            "stilbene",
            "polygonum multiflorum thunb",
            "quality control",
            "5",
            "-tetrahydroxy-stilbene-2-o-\u03b2-d-glucoside",
            "4",
            "quantitative analysis",
            "chemical composition",
            "analytical methods",
            "hplc",
            "quality controls"
        ],
        "year": 2009
    },
    "b2FWBwnc": {
        "id": "b2FWBwnc",
        "title": "Fingerprint chromatograms of chemical principles of Rhizoma Chuansiong By HPLC",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SONG Wen-ting",
                "org": "Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "qualitative control",
            "fingerprint chromatograms",
            "Rhizoma Chuansiong"
        ],
        "year": 2006
    },
    "D35nEbaS": {
        "id": "D35nEbaS",
        "title": "Determination by HPLC of the contents of four flavonoids in effective fraction of Kushen Decoction",
        "authors": [
            {
                "name": "Liu Bin",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing "
            },
            {
                "name": "Shi Renbing",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing "
            },
            {
                "name": "Jiang Yanyan",
                "org": "Beijing University of Traditional Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "baicalin",
            "Kushen Decoction",
            "effective fraction",
            "quantitative determination",
            "flavone"
        ],
        "year": 2005
    },
    "Szkgv4h2": {
        "id": "Szkgv4h2",
        "title": "Constituents in the alkaloid fraction of Kushen decoction]",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacology,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacology,Beijing University of Traditional Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "kushen decoction",
            "alkaloids"
        ],
        "year": 2006
    },
    "AgTvyRow": {
        "id": "AgTvyRow",
        "title": "Method for determination of total chromone in chromone fraction of Saposhnikovia divaricata (Turcz.) Schischk.",
        "authors": [
            {
                "name": "JIANG Yan-yan",
                "org": "School of Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Materia Medica,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "hamaudol",
            "chromatoptometry",
            "content determination",
            "total chromone",
            "Saposhnikovia divaricata (Turcz.) Schischk."
        ],
        "year": 2007
    },
    "ZTV1BflG": {
        "id": "ZTV1BflG",
        "title": "Study on Chemical Constituents of Folium Nelumbinis",
        "authors": [
            {
                "name": "WANG Ling-ling",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": " School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "natural product research and development",
        "keywords": [
            "4aS",
            "(2R",
            "chemical constituents",
            "8aS)-4",
            "4a-epoxy-4",
            "Folium Nelumbinis",
            "4S",
            "4a-dihydroedulan"
        ],
        "year": 2009
    },
    "oKWc3DF1": {
        "id": "oKWc3DF1",
        "title": "Radical Scavenging Activity of Oxtropis myriophylla",
        "authors": [
            {
                "name": "SHE Gai-mei",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SUN Fang-fang",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LV Hai-ning",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of experimental traditional medical formulae",
        "keywords": [
            "Oxtropis myriophylla",
            "anti-oxidant",
            "scavenging capacity of free radical"
        ],
        "year": 2010
    },
    "7kUerNN8": {
        "id": "7kUerNN8",
        "title": "Study on adscription of plasma effective constituents of rat after administrated with alkaloid fraction of Nelumbo nucifera",
        "authors": [
            {
                "name": "WU Hao",
                "org": "TCM College,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "TCM College,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "TCM College,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "TCM College,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Yu-xia",
                "org": "TCM College,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "china journal of traditional chinese medicine and pharmacy",
        "keywords": [
            "hplc",
            "effective constituents",
            "nelumbo nucifera",
            "alkaloid fraction",
            "chemical composition"
        ],
        "year": 2009
    },
    "UXgyBmbW": {
        "id": "UXgyBmbW",
        "title": "Rubrofusarin-6-O-\u03b2-gentiobioside: chemical reference of Juemingzi(Semen Cassiae)",
        "authors": [
            {
                "name": "XU Dong-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "JIANG Yan-yan",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "ZHANG Chen",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "TLC",
            "Juemingzi(Semen Cassiae)",
            "rubrofusarin-6-O-\u03b2-gentiobioside",
            "reference"
        ],
        "year": 2011
    },
    "wYz21m8E": {
        "id": "wYz21m8E",
        "title": "Flavonoid chemical compositions of Folium nelumbinis",
        "authors": [
            {
                "name": "WANG Ling-ling",
                "org": "(1 School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "(1 School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "(1 School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "TU Guang-zhong",
                "org": " Beijing Institute of Microchemistry"
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "chrysoeriol-7-O-\u03b2-D-glucuroside",
            "Folium nelumbinis",
            "quercetin3-O-\u03b2-D-xylopyranosyl(1\u21922)-\u03b2-D-glucopyranoside",
            "isorhamnetin",
            "flavonoids"
        ],
        "year": 2008
    },
    "JK4R0DfQ": {
        "id": "JK4R0DfQ",
        "title": "Study of New Cultivation Principle and Creative Mode of Chinese Pharmaceutical Scholars Based on Teaching Team",
        "authors": [
            {
                "name": "ZHAI Huaqiang",
                "org": "School of TCM,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHANG Bing",
                "org": "School of TCM,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "ZHENG Huzhan",
                "org": "School of TCM,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SUN Jianning",
                "org": "School of TCM,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of TCM,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "pharmaceutical education",
        "keywords": [
            "Demonstrative teaching standard",
            "Innovate teaching philosophy",
            "Teaching team"
        ],
        "year": 2009
    },
    "NsvcFrwT": {
        "id": "NsvcFrwT",
        "title": "Influence of different component combinations of Sini Powder on decocting quantity of saikosaponin-a and b2",
        "authors": [
            {
                "name": "LI Jun",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "saikosaponin-b2",
            "saikosaponin-a",
            "component combination study of Chinese herbal drugs",
            "total saikosaponin",
            "Sini Powder"
        ],
        "year": 2007
    },
    "Ff9WTdLz": {
        "id": "Ff9WTdLz",
        "title": "The inhibiting effect of polygoni multiflori total glycosides (PMTG) on the atherosclerotic lesion formation in experimental atherosclerosis]",
        "authors": [
            {
                "name": "Fang Wei"
            },
            {
                "name": "Zhang Hui-xin"
            },
            {
                "name": "Wang L\u00fc-ya"
            },
            {
                "name": "Wu Ying"
            },
            {
                "name": "Qin Yan-wen"
            },
            {
                "name": "Wang Wei"
            },
            {
                "name": "Du Lan-ping"
            },
            {
                "name": "Liu Bin"
            }
        ],
        "venue": "zhonghua bing li xue za zhi chinese journal of pathology",
        "keywords": [],
        "year": 2005
    },
    "idaimo2k": {
        "id": "idaimo2k",
        "title": "Quantitative Determination of puerarin, 3\u2032-methoxyl-puerarin, mirificin, daidzin and paeoniflorin in Yishendaluofang by RP-HPLC",
        "authors": [
            {
                "name": "Wang Yan-zhi",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "Shi Ren-bing",
                "org": "Beijing University of Chinese Medicine, Beijing "
            },
            {
                "name": "liu Bin",
                "org": "Beijing University of Chinese Medicine, Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "daidzin",
            "puerarin",
            "RP-HPLC",
            "3\u2032-methoxyl-puerarin",
            "Yishendaluo Formula",
            "mirificin",
            "paeoniflorin"
        ],
        "year": 2006
    },
    "J9wVP9Sa": {
        "id": "J9wVP9Sa",
        "title": "HPLC simultaneous determination of two triterpene saponins in Ilex pubescens",
        "authors": [
            {
                "name": "ZHOU Zhong-liu",
                "org": "Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang ,China;Colege of Chemistry and Chemical Engineering,Guangxi Normal University,Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education of China,Guilin ,China;School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "FU Chun-yan",
                "org": "Colege of Chemistry and Chemical Engineering,Guangxi Normal University,Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Education of China,Guilin ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "XIA Jing-min",
                "org": "Chemistry Science and Technology School,Zhanjiang Normal University,Zhanjiang ,China"
            }
        ],
        "venue": "chinese journal of pharmaceutical analysis",
        "keywords": [
            "HPLC",
            "ilexsaponin B2",
            "ilexsaponin B1",
            "triterpene saponins",
            "Ilex pubescens",
            "quantitative determination"
        ],
        "year": 2011
    },
    "fe764ae3": {
        "id": "fe764ae3",
        "title": "Two new compounds from active fractions of Qingnao Xuanqiao Formula",
        "authors": [
            {
                "name": "LI Xiao",
                "org": "College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            },
            {
                "name": "LIU Bin",
                "org": "College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            },
            {
                "name": "CHEN Yu-ping",
                "org": "College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            },
            {
                "name": "SUN Jian-ning",
                "org": "College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing , China"
            }
        ],
        "venue": "chinese traditional and herbal drugs",
        "keywords": [
            "Active fraction",
            "Chemical constituents",
            "Qingnao Xuanqiao Formula"
        ],
        "year": 2007
    },
    "6crmHRtI": {
        "id": "6crmHRtI",
        "title": "Influences of effective fraction and active components of Jiangzhining on cholesterol metabolism",
        "authors": [
            {
                "name": "YANG Ying",
                "org": " Medical College of Inner Mongolia,Inner Mongolian Autonomous Region "
            },
            {
                "name": "LIU Bin",
                "org": " Beijing University of Chinese Medicine"
            },
            {
                "name": "WANG Wei",
                "org": " Beijing University of Chinese Medicine"
            },
            {
                "name": "BI Li-fu",
                "org": " Medical College of Inner Mongolia,Inner Mongolian Autonomous Region "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "active components",
            "Jiangzhining",
            "effective fraction",
            "cholesterol metabolism",
            "hepatic cells"
        ],
        "year": 2009
    },
    "8cn1UrpS": {
        "id": "8cn1UrpS",
        "title": "Preparation methods and composition study of decoction of Radix Salviae Miltiorrhizae based on fingerprint chromatogram representation",
        "authors": [
            {
                "name": "LIU Yang",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIANG Ji-chun",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SONG Wen-ting",
                "org": "School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "HPLC",
            "decoction",
            "processing",
            "chemical compositions",
            "Radix Salviae Miltiorrhizae"
        ],
        "year": 2009
    },
    "362CQM0p": {
        "id": "362CQM0p",
        "title": "Study on the extraction of total alkaloid from folium nelumbinis with ultrasonic wave technology optimized by central composite design and response surface method]",
        "authors": [
            {
                "name": "WANG Fu-gang",
                "org": "College of pharmacy,Taishan Medical University,Taian ,China;College of Chinese Traditional Medicine,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "CAO Juan",
                "org": "College of pharmacy,Taishan Medical University,Taian ,China"
            },
            {
                "name": "LIU Bin",
                "org": "College of Chinese Traditional Medicine,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Yu-xia",
                "org": "College of Chinese Traditional Medicine,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "GAO Yun-sheng",
                "org": "College of pharmacy,Taishan Medical University,Taian ,China"
            },
            {
                "name": "CHEN Jing",
                "org": "College of pharmacy,Taishan Medical University,Taian ,China"
            }
        ],
        "venue": "zhong yao cai = zhongyaocai = journal of chinese medicinal materials",
        "keywords": [
            "total alkaloid",
            "central composite design",
            "folium nelumbinis",
            "response surface method"
        ],
        "year": 2011
    },
    "1i2zQL3G": {
        "id": "1i2zQL3G",
        "title": "Chemical principles in flavonoid fraction of alcohol extract from Kushen Decoction",
        "authors": [
            {
                "name": "LIU Bin",
                "org": "School of Materia Medica,Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Materia Medica,Beijing University of Chinese Medicine,Beijing "
            }
        ],
        "venue": "journal of beijing university of traditional chinese medicine",
        "keywords": [
            "Kushen Decoction",
            "4-dihydroxy-4'",
            "2'",
            "6'-dimethoxychalcone",
            "flavonoids"
        ],
        "year": 2007
    },
    "RuNnTa1S": {
        "id": "RuNnTa1S",
        "title": "Study on Quality Evaluation of Jiangzhining Based on Anti-oxidative Activity",
        "authors": [
            {
                "name": "XU Dong-yan",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "chinese journal of experimental traditional medical formulae",
        "keywords": [
            "quality evaluation",
            "DPPH free radical scan",
            "Jiangzhining",
            "anti-oxidation"
        ],
        "year": 2010
    },
    "paO0shzv": {
        "id": "paO0shzv",
        "title": "Fingerprint of Fructus Crataegus by HPLC",
        "authors": [
            {
                "name": "LUO Wen",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            },
            {
                "name": "SHI Ren-bing",
                "org": "School of Chinese Pharmacy,Beijing University of Chinese Medicine,Beijing ,China"
            }
        ],
        "venue": "modern pharmacy and clinic",
        "keywords": [
            "HPLC",
            "fingerprint",
            "Crataegus pinnatifida Bge.var.major N.E.Br",
            "C. pinnatifida Bge."
        ],
        "year": 2009
    },
    "gJQvcFNK": {
        "id": "gJQvcFNK",
        "title": "Effect of PMTG on atherosclerotic lesion formation and expression of ICAM-1 and VCAM-1 in ApoE-deficient mice]",
        "authors": [
            {
                "name": "FANG Wei",
                "org": "Department of Pathology,the Affiliated Hospital of the Capital Medical University of Beijing Anzhen Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Hui-xin",
                "org": "Department of Pathology,the Affiliated Hospital of the Capital Medical University of Beijing Anzhen Hospital,Beijing ,China"
            },
            {
                "name": "WANG Lu-ya",
                "org": "Department of Atherosclerotic Diseases,Beijing Institute of Heart and Lung Diseases,Beijing ,China"
            },
            {
                "name": "QIN Yan-wen",
                "org": "Department of Atherosclerotic Diseases,Beijing Institute of Heart and Lung Diseases,Beijing ,China"
            },
            {
                "name": "WU Ying",
                "org": "Department of Pathology,the Affiliated Hospital of the Capital Medical University of Beijing Anzhen Hospital,Beijing ,China"
            },
            {
                "name": "WANG Wei",
                "org": "Department of Pathology,the Affiliated Hospital of the Capital Medical University of Beijing Anzhen Hospital,Beijing ,China"
            },
            {
                "name": "LIU Bin",
                "org": "Beijng Chinese medical university,Beijing ,China"
            }
        ],
        "venue": "zhongguo zhong yao za zhi = zhongguo zhongyao zazhi = china journal of chinese materia medica",
        "keywords": [
            "vcam-1",
            "atherosclerosis",
            "icam-1",
            "polygoni multiflori total gycosides(pmtg)",
            "apoe gene-deficient mice"
        ],
        "year": 2007
    },
    "JTAchXAy": {
        "id": "JTAchXAy",
        "title": "Determination of the trace elements in Grubthobrildkr by ICP-MS",
        "authors": [
            {
                "name": "LIU Bin",
                "org": " Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "LIU Hui",
                "org": " Beijing University of Chinese Medicine, Beijing , China"
            },
            {
                "name": "WANG Ying-feng",
                "org": " Capital Normal University, Beijing , China"
            }
        ],
        "venue": "journal of medicine & pharmacy of chinese minorities",
        "keywords": [
            "Grubthobrildkr",
            "ICP-MS",
            "trace element",
            "microwave digestinon"
        ],
        "year": 2011
    },
    "YweS4BUj": {
        "id": "YweS4BUj",
        "title": "Hemochromatosis gene (HFE) polymorphisms and risk of type 2 diabetes mellitus: a meta-analysis.",
        "abstract": "The hemochromatosis gene (HFE) has been involved in the etiology of type 2 diabetes mellitus and investigated in numerous epidemiologic studies. The current meta-analysis was conducted to evaluate the gene-disease association in relevant studies. Electronic literature search was performed on June 18, 2011, from databases of PubMed/MEDLINE, EMBASE, and HuGE Navigator. Articles were inspected by 2 authors independently, and data were extracted by identical extraction form. A total of 5,528 type 2 diabetes cases and 6,920 controls in relation to HFE polymorphisms (a cysteine to tyrosine substitution at amino acid position 282 (C282Y) and a histidine to aspartate substitution at amino acid position 63 (H63D)) were included in the meta-analysis (1997-2011). A fixed- or random-effect model was used to calculate the pooled odds ratios based on the results from the heterogeneity tests. An increased odds ratio for type 2 diabetes mellitus was observed in persons carrying a D allele at the H63D polymorphism compared with those with an H allele (odds ratio (OR) = 1.21, 95% confidence interval (CI): 1.03, 1.41; P = 0.02). Moreover, carriers of a D allele had a modestly increased risk compared with persons with the wild genotype (OR = 1.12, 95% CI: 1.00, 1.25; P = 0.04). The C282Y variant was not significantly associated with diabetes risk. In summary, persons with a D allele may have a moderately increased risk of type 2 diabetes mellitus.",
        "keywords": [],
        "authors": [
            {
                "name": "Rong Ying",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Bao Wei",
                "org": ""
            },
            {
                "name": "Rong Shuang",
                "org": ""
            },
            {
                "name": "Fang Min",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Hu Frank B",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            }
        ],
        "venue": "American journal of epidemiology",
        "year": 2012
    },
    "vPSHJAAn": {
        "id": "vPSHJAAn",
        "title": "Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population.",
        "abstract": "Our previous study has recently shown that plasma heme oxygenase-1 (HO-1), a stress-responsive protein, is elevated in individuals with type 2 diabetes. The current study aimed to examine the association between plasma HO-1 concentration and impaired glucose regulation (IGR) in non-diabetic individuals.We conducted a case-control study including a total of 865 subjects (262 IGR individuals and 603 healthy controls) in a Chinese population. Basic characteristics were collected by questionnaire and standardized anthropometric measurements. Plasma HO-1 concentration was determined by ELISA.Plasma HO-1 concentration was significantly increased in IGR individuals compared with healthy controls (1.34 (0.81-2.29) ng/ml vs 0.98 (0.56-1.55) ng/ml, P<0.001). After adjustment for age, sex, and BMI, the ORs for IGR in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 3.42 (95% CI 2.11-5.54; P for trend <0.001). The trend remained significant even after additional adjustment for smoking, alcohol drinking, hypertension, family history of diabetes, lipid profiles and C-reactive protein. In the receiver-operating characteristic curve analysis, addition of plasma HO-1 concentration to a model with known risk factors yielded significantly improved discriminative value for IGR (area under the curves 0.75 (95% CI 0.71-0.78) vs. 0.72 (95% CI 0.69-0.76); P for difference\u200a=\u200a0.026).Elevated plasma HO-1 concentration is significantly associated with increased ORs for IGR. However, its clinical utility should be validated in further studies, especially in prospective cohort studies.",
        "keywords": [
            "biology",
            "metabolism",
            "endocrinology",
            "epidemiology",
            "physiology",
            "biochemistry",
            "anatomy",
            "roc curve",
            "medicine",
            "case control studies",
            "area under curve"
        ],
        "authors": [
            {
                "name": "Bao Wei",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China."
            },
            {
                "name": "Rong Shuang",
                "org": ""
            },
            {
                "name": "Zhang Muxun",
                "org": ""
            },
            {
                "name": "Yu Xuefeng",
                "org": ""
            },
            {
                "name": "Zhao Yanting",
                "org": ""
            },
            {
                "name": "Xiao Xiao",
                "org": ""
            },
            {
                "name": "Yang Wei",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Hu Frank B",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2012
    },
    "fxlKZCXt": {
        "id": "fxlKZCXt",
        "title": "Leucine facilitates the insulin-stimulated glucose uptake and insulin signaling in skeletal muscle cells: involving mTORC1 and mTORC2.",
        "abstract": "Leucine, a branched-chain amino acid, has been shown to promote glucose uptake and increase insulin sensitivity in skeletal muscle, but the exact mechanism remains unestablished. We addressed this issue in cultured skeletal muscle cells in this study. Our results showed that leucine alone did not have an effect on glucose uptake or phosphorylation of protein kinase B (AKT), but facilitated the insulin-induced glucose uptake and AKT phosphorylation. The insulin-stimulated glucose uptake and AKT phosphorylation were inhibited by the phosphatidylinositol 3-kinase inhibitor, wortmannin, but the inhibition was partially reversed by leucine. The inhibitor of mammalian target of rapamycin complex 1 (mTORC1), rapamycin, had no effect on the insulin-stimulated glucose uptake, but eliminated the facilitating effect of leucine in the insulin-stimulated glucose uptake and AKT phosphorylation. In addition, leucine facilitation of the insulin-induced AKT phosphorylation was neutralized by knocking down the core component of the mammalian target of rapamycin complex 2 (mTORC2) with specific siRNA. Together, these findings show that leucine can facilitate the insulin-induced insulin signaling and glucose uptake in skeletal muscle cells through both mTORC1 and mTORC2, implicating the potential importance of this amino acid in glucose homeostasis and providing new mechanistic insights.",
        "keywords": [],
        "authors": [
            {
                "name": "Liu Hui",
                "org": "Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, Hubei, China."
            },
            {
                "name": "Liu Rui",
                "org": ""
            },
            {
                "name": "Xiong Yufang",
                "org": ""
            },
            {
                "name": "Li Xiang",
                "org": ""
            },
            {
                "name": "Wang Xiaolei",
                "org": ""
            },
            {
                "name": "Ma Yan",
                "org": ""
            },
            {
                "name": "Guo Huailan",
                "org": ""
            },
            {
                "name": "Hao Liping",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Yang Xuefeng",
                "org": ""
            }
        ],
        "venue": "Amino acids",
        "year": 2014
    },
    "edleURRi": {
        "id": "edleURRi",
        "title": "Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: a systematic review and meta-analysis.",
        "abstract": "This systematic review and meta-analysis was conducted to estimate the effects of intravenous and nebulized magnesium sulfate on treating adults and children with acute asthma.Electronic literature search and the manual search of key respiratory journals were performed up to October 18, 2011. Randomized controlled trials were included if patients had been treated with intravenous or nebulized magnesium sulfate in combination with \u03b22-agonists and were compared with the use of \u03b22-agonists. Standardized mean differences (SMDs) and the relative risks (RRs) were calculated for pulmonary functions and hospital admission respectively.25 trials (16 intravenous, 9 nebulized) involving 1754 patients were included. In adults intravenous treatment was associated with a significant effect upon respiratory function (SMD, 0.30; 95% confidence interval (CI), 0.05 to 0.55; p = 0.02) but weak evidence of effect upon hospital admission (RR 0.86,95% CI 0.73 to 1.01; p = 0.06) in adults, and in children with significant effects upon both respiratory function (SMD, 1.94; 95% CI, 0.80 to 3.08; p = 0.0008) and hospital admission (RR, 0.70; 95% CI, 0.54 to 0.91; p = 0.008). Nebulized treatment was associated with significant effects upon respiratory function (SMD, 0.23; 95% CI, 0.06 to 0.41; p = 0.009) and hospital admission (RR, 0.63; 95% CI, 0.43 to 0.92; p = 0.02) in adults.The use of intravenous magnesium sulfate, in addition to \u03b22-agonists and systemic steroids, in the treatment of acute asthma appears to produce benefits with respect to improve pulmonary function and reduce the number of hospital admissions for children, and only improve pulmonary function for adults. However, the use of nebulized magnesium sulfate just appears to produce benefits for adults.",
        "keywords": [
            "systematic review",
            "magnesium sulfate"
        ],
        "authors": [
            {
                "name": "Shan Zhilei",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science &amp; Technology, 13 Hangkong Road, Wuhan 430030, PR China."
            },
            {
                "name": "Rong Ying",
                "org": ""
            },
            {
                "name": "Yang Wei",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Xie Jungang",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            }
        ],
        "venue": "Respiratory medicine",
        "year": 2013
    },
    "1EZR2wDZ": {
        "id": "1EZR2wDZ",
        "title": "Effects of vitamin A deficiency on growth and development of female rats",
        "abstract": "Objective To investigate the effects of different levels of vitamin A deficiency(VAD) on the growth and development of female rats and their embryos.Methods Weaning female SD rats were randomly divided into 3 groups,VA deficient group(AD),VA marginally deficient group(AM),VA normal group(AN).3 groups were fed different levels of VA.After being fed 50 days for depleting the VA store in body,the female rats copulated with male rats.All the copulated rats were randomly divided into 4 groups:VA deficient group(A),VA supplement group(B),VA marginally deficient group(C),VA marginally deficient supplement group(D).Both the B and D groups were fed VA-supplement diet at embryonic day 0(E0).All the rats were sacrificed at E19.5.Results The growth and development of AD group was seriously retarded and some of them could not reproduce normally while the group AM was normal.All the embryos in group A were resorbted.The embryos with smaller size,malformation,early death were significant higher in group C compared with AN and supplement groups(B,D).Conclusion Serious VAD can inhibit the growth and development of female rats and prevent their maturity and reproduction,and its malformation and lethality of embryo were notable.The supplement of VA can decrease the malformation and lethality of embryos during pregnancy.",
        "keywords": [
            "vitamin A deficiency",
            "embryonic toxicity",
            "growth and development"
        ],
        "authors": [
            {
                "name": "LI Na",
                "org": "Wuhan ,China"
            },
            {
                "name": "SUN Shan-shan",
                "org": "Wuhan ,China"
            },
            {
                "name": "WANG Di",
                "org": "Wuhan ,China"
            }
        ],
        "venue": "Chinese Journal of Public Health",
        "year": 2007
    },
    "lsPwE4sK": {
        "id": "lsPwE4sK",
        "title": "EFFECTS OF VITAMIN A DEFICIENCY AND SUPPLEMENTATION ON EMBRYONIC SURVIVAL AND EXPRESSION OF HOXA-2 AND HOXB-2 IN HINDBRAIN OF RAT EMBRYOS",
        "abstract": "Objective: To investigate the effects of vitamin A (VA) on embryonic survival via induction of Hoxa-2 and Hoxb-2 mRNA expression. Method: Weanling female SD rats were fed VA-deficient diet or VA-supplemented diet for 7 w to develop marginal VA-deficient model or control. After mating, pregnant marginal VA-deficient mice were fed VA-deficient or VA-supplement diets starting at embryonic day 0 (E0). Serum VA concentration was determined by spectrofluorimetric micromethod. Embryonic survival at E12.5 and E19.5 was examined. By reverse transcription polymerse chain reaction (RT-PCR) technique the expression levels of Hoxa-2 and Hoxb-2 mRNA in hindbrain at E12.5 were detected. Results: Serum VA concentration, the number of live embryos and expression levels of Hoxa-2 and Hoxb-2 mRNA were reduced significantly than those of control group, while the number of dead and resorbed embryos were increased significantly. There was no difference of these parameters in VA-supplement group starting at E0 compared with control group. Conclusion: The essential role of VA in embryonic survival is possibly attributed to the induction of Hoxa-2 and Hoxb-2 mRNA expression in embryonic hindbrain at E12.5.",
        "keywords": [
            "embryonic survival",
            "vitamin A deficiency",
            "Hoxb-2",
            "Hoxa-2"
        ],
        "authors": [
            {
                "name": "SUN Shan-shan",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,China"
            },
            {
                "name": "LI Na",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,China"
            },
            {
                "name": "WANG Di",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,China"
            },
            {
                "name": "YAO Ping",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,China"
            },
            {
                "name": "ZHAO Yao-wu",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,China"
            },
            {
                "name": "LIU Lie-gang",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan ,China"
            }
        ],
        "venue": "Acta Nutrimenta Sinica",
        "year": 2007
    },
    "dCmR2gm3": {
        "id": "dCmR2gm3",
        "title": "Evaluation of reproductive and developmental toxicities of Pu-erh black tea (Camellia sinensis var. assamica) extract in Sprague Dawley rats.",
        "abstract": "Pu-erh black tea, which is obtained by first parching crude green tea leaves and followed by secondary fermentation with microorganisms, has been believed to be beneficial beverages for health in PR China. But its potential toxicity when administered at a high dose as concentrated extract has not been completely investigated.The present study was aimed at evaluating potential reproductive and developmental toxicities of Pu-erh black tea extract (BTE) in Sprague Dawley rats.Growing rats were given BTE by gavage at levels of 0, 200, 700 and 2500mg/kg/day as the F0 generation in reproductive toxicity study. Additionally, BTE was administered to mate female rats from gestation day 0.5 through 19.5 at the doses of 0, 200, 700 and 2500mg/kg/day to evaluate the developmental toxicity.In the reproductive toxicity study, only 2500mg/kg/day BTE reduced the body weight gain and altered the relative organ weights including testes, prostata and ovary both for F0 parents and F1 offspring compared to the controls. High dose of BTE (2500mg/kg/day) administration caused developmental disturbances in embryo-to-foetus period including resorbed embryos, decreased embryo size and skeletal anomalies.In conclusion, the no-observed-adverse-effect level of BTE is 700mg/kg/day both for reproductive toxicity and developmental toxicities.",
        "keywords": [],
        "authors": [
            {
                "name": "Wang Di",
                "org": "Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science &amp; Technology, 13 Hangkong Road, Wuhan 430030, PR China."
            },
            {
                "name": "Meng Jie",
                "org": ""
            },
            {
                "name": "Gao Hui",
                "org": ""
            },
            {
                "name": "Xu Kunlong",
                "org": ""
            },
            {
                "name": "Xiao Rong",
                "org": ""
            },
            {
                "name": "Zhong Ying",
                "org": ""
            },
            {
                "name": "Luo Xiao",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Yan Hong",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2013
    },
    "5RLMQOdt": {
        "id": "5RLMQOdt",
        "title": "Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone.",
        "abstract": "3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide (Quinocetone, QCT) is a newly used veterinary drug which has been proven to promote feed efficiency and growth of animals; however, its potential toxicity can't be ignored. Therefore, the present study was aimed to investigate the nephrotoxicity of QCT and the oxidative stress induced by it. Sprague-Dawley rats (SD rats) were randomly divided into four groups with doses of 2400, 800, 50 and 0mg/kg/day with administration of QCT for 4 weeks. Results proved that QCT could induce nephrotoxicity and this phenomenon had dose dependent manner. Simultaneously, this phenomenon was accompanied by intracellular reactive oxygen species (ROS) accumulation, enhanced lipid peroxidation and inhibited antioxidant system, i.e. glutathione S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GSH). Additionally, the higher expression of Nrf2 in QCT treated groups illustrated that QCT-induced oxidative stress would be partly mitigated by the induction of phase II detoxifying enzymes via increasing Nrf2 expression.",
        "keywords": [],
        "authors": [
            {
                "name": "Yu Miao",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Xu Mengjing",
                "org": ""
            },
            {
                "name": "Liu Yang",
                "org": ""
            },
            {
                "name": "Yang Wei",
                "org": ""
            },
            {
                "name": "Rong Ying",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Yan Hong",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            }
        ],
        "venue": "Regulatory toxicology and pharmacology : RTP",
        "year": 2013
    },
    "FEARAyDe": {
        "id": "FEARAyDe",
        "title": "Inflammatory markers and risk of type 2 diabetes: a systematic review and meta-analysis.",
        "abstract": "There has been growing evidence that inflammatory markers play a role in the development of type 2 diabetes. We aimed to systematically review prospective studies on the associations of elevated levels of interleukin-6 (IL-6) and C-reactive protein (CRP) with increased risk of type 2 diabetes by conducting a meta-analysis.A systematic search of the PubMed, EMBASE, ISI Web of Knowledge, and Cochrane Library databases up until 10 February 2012 was conducted to retrieve prospective studies matched to search terms. We used generalized least-squares trend estimation to assess dose-response relationships. The summary risk estimates were pooled using either fixed-effects or random-effects models to incorporate between-study variation.The meta-analysis, including 10 prospective studies, with a total of 19,709 participants and 4,480 cases, detected a significant dose-response association of IL-6 levels with type 2 diabetes risk (relative risk [RR] 1.31 [95% CI 1.17-1.46]). For CRP, the meta-analysis involving 22 cohorts, with a total of 40,735 participants and 5,753 cases, showed that elevated CRP levels were significantly associated with increased risk of type 2 diabetes (1.26 [1.16-1.37]), with the absence of publication bias. Sensitivity and subgroup analyses further supported the associations.This meta-analysis provides further evidence that elevated levels of IL-6 and CRP are significantly associated with increased risk of type 2 diabetes.",
        "keywords": [
            "interleukin 6",
            "risk factors"
        ],
        "authors": [
            {
                "name": "Wang Xia",
                "org": "Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China."
            },
            {
                "name": "Bao Wei",
                "org": ""
            },
            {
                "name": "Liu Jun",
                "org": ""
            },
            {
                "name": "Ouyang Ying-Ying",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Rong Shuang",
                "org": ""
            },
            {
                "name": "Xiao Xiao",
                "org": ""
            },
            {
                "name": "Shan Zhi-Lei",
                "org": ""
            },
            {
                "name": "Zhang Yan",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "Liu Lie-Gang",
                "org": ""
            }
        ],
        "venue": "Diabetes care",
        "year": 2013
    },
    "UEG8MMyA": {
        "id": "UEG8MMyA",
        "title": "Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats.",
        "abstract": "Quinocetone (3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide, QCT) is a widely used veterinary drug in PR China that promotes feed efficiency and growth of various animals. However, its potential toxicity has been concerned recently. In the present study, we investigated QCT-induced hepatocyte changes and its related mechanism, especially the expression of Nrf2/HO-1 pathway. Oxidative stress induced by QCT in hepatocyte led to DNA damage, inflammation and apoptosis. Nevertheless, hepatocyte has a self-repair system to protect itself from oxidative stress. In the 50 mg/kg/day QCT group, the morphology and function of liver were approximately maintained on normal level, which indicated that the damaged cell might have a self-repair mechanism. Notably, nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) pathway plays a critical role in protecting cells against reactive oxygen species (ROS) generation. However, higher doses of QCT (800 mg/kg/day and 2400 mg/kg/day) inhibited the expression of Nrf2/HO-1 pathway, which resulted in excessive ROS generation and irreversible oxidative DNA damage, inflammation and apoptosis. In conclusion, although QCT-induced oxidative stress activates the expression of Nrf2/HO-1 pathway initially, persistent QCT exposure will inhibit this expression and aggravate hepatocyte damage. Simultaneously, inflammation and apoptosis continues to progress, liver dysfunction and tissue damage will be occurred eventually.",
        "keywords": [
            "nrf2/ho-1 pathway",
            "oxidative stress",
            "quinocetone"
        ],
        "authors": [
            {
                "name": "Yu Miao",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Wang Di",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Xu Mengjing",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Liu Yang",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Wang Xia",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Liu Jun",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Yang Xuefeng",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Yao Ping",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Yan Hong",
                "org": "Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            },
            {
                "name": "Liu Liegang",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China."
            }
        ],
        "venue": "Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association",
        "year": 2014
    },
    "zCmyKnzd": {
        "id": "zCmyKnzd",
        "title": "Effects of three kinds of curcuminoids on anti-oxidative system and membrane deformation of human peripheral blood erythrocytes in high glucose levels.",
        "abstract": "Curcuminoids are the main bioactive constituents of the rhizome of turmeric. Erythrocytes lesions in diabetes are probably related to hyperglycemia and protein glycation. It has been reported that curcumin prevent lipid peroxidation. However, reports on the effects of demethoxycurcumin and bis-demethoxycurcumin on human erythrocytes at high glucose levels are scarce. Our aim is to investigate the effect of curcuminoids on oxidative stress and membrane of erythrocytes exposed to hyperglycemic condition.In this study, the different blood samples were treated with two doses of glucose (10 or 30 mM) to mimic hyperglycemia in the presence or absence of three kinds of curcuminoids (5 or 10 \u03bcM) in a medium at 37 \u00b0C for 24 h (Each experiment consists of 20 blood samples from 10 male and 10 female volunteers). The malondialdehyde was checked by HPLC, antioxidase (GSH and GSSG) were measured by LC/MS, SOD was checked by WST-1 kit, morphology and phospholipid symmetry were detected by flow cytometry, confocal scanning microscope and scanning electron microscope.The results illustrated that all three curcuminoids reduce oxidative stress damage on the membrane and maintain a better profile for erythrocytes. Furthermore, three curcuminoids had benefit effects on antioxidase.The three kinds of curcuminoids supplementation may prevent lipid peroxidation at different intensity and membrane dysfunction of human erythrocytes in hyperglycemia.",
        "keywords": [
            "cell morphology",
            "diabetes"
        ],
        "authors": [
            {
                "name": "Yang Wei",
                "org": "Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
            },
            {
                "name": "Fu Juan",
                "org": ""
            },
            {
                "name": "Yu Miao",
                "org": ""
            },
            {
                "name": "Wang Di",
                "org": ""
            },
            {
                "name": "Rong Ying",
                "org": ""
            },
            {
                "name": "Yao Ping",
                "org": ""
            },
            {
                "name": "N\u00fcssler Andreas K",
                "org": ""
            },
            {
                "name": "Yan Hong",
                "org": ""
            },
            {
                "name": "Liu Liegang",
                "org": ""
            }
        ],
        "venue": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology",
        "year": 2015
    },
    "0AG41NCZ": {
        "id": "0AG41NCZ",
        "title": "EFFECTS OF MARGINAL VITAMIN A DEFICIENCY ON SKELETON DEVELOPMENT AND EXPRESSION OF RETINOIC ACID RECEPTORS OF RAT EMBRYOS",
        "abstract": "Objective To investigate the association between the effects of marginal vitamin A deficiency and supplement on skeleton development and the expression of retinoic acid receptors of rat embryos. Methods The weaning female SD rats were randomly divided into 3 groups, marginal VA deficiency group (AM), VA-supplement group (AS), VA normal group (AN). The VA contents in diet were: 0.4 IU/g diet (AM, AS), 4 IU/g diet (AN). After 60 d, the female rats were mated with male rats. The AS group shift to AS diet (10 IU/g diet) on E0 d. All rats were sacrificed on E12.5 or E19.5. The skeleton development was surveyed on E19.5 embryos. The retinoic acid receptors (RARs) expression was detected with SYBR Green RT-PCR and Western blot on E12.5 embryos. Results The expression of RAR\u03b2 and RAR\u03b3 and the skeleton development of embryos of AM group were reduced significantly than those of control group, whereas there was no difference of these indices in AS group relative to control group. Conclusion The RARs paly an essential role in mediating the skeleton malformation resulting from marginal VA-deficiency, and VA-supplement in early pregnancy is effective to prevent this abnormality.",
        "keywords": [
            "retinoic acid receptors",
            "skeleton development",
            "vitamin a deficiency",
            "rt-pcr",
            "embryos",
            "genes",
            "skeleton",
            "gene expression"
        ],
        "authors": [
            {
                "name": "LI Na",
                "org": "Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  , China"
            },
            {
                "name": "SUN Shan-shan",
                "org": "Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  , China"
            },
            {
                "name": "WANG Di",
                "org": "Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  , China"
            },
            {
                "name": "YAO Ping",
                "org": "Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  , China"
            },
            {
                "name": "YANG Xuefeng",
                "org": "Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  , China"
            },
            {
                "name": "LIU Lie-gang",
                "org": "Department of Nutrition and Food Hygiene, Tongji Medical College, Huazhong University of Science and Technology, Wuhan  , China"
            }
        ],
        "venue": "Acta Nutrimenta Sinica",
        "year": 2009
    },
    "p6OLAK7c": {
        "id": "p6OLAK7c",
        "title": "Effect of \u03b1-linolenic acid on anti-oxidative system and membrane structure of human peripheral erythrocytes in high glucose level",
        "abstract": "Objective To investigate whether \u03b1-linolenic acid could protect erythrocyte membrane structure in high glucose level and whether this effect could attenuate the oxidative stress induced by high glucose and improve the antioxidative capacity of erythrocytes.Methods The malondialdehyde and L-glutathione were detected by HPLC and LC/MS respectively.The membrane phospholipids asymmetry and fatty acid composition of membrane were demonstrated by FCM and GC respectively.The morphology of erythrocyte was illuminated by ultra scanning electron microscopy.Results It was found that:(1) the concentrations of MDA of three \u03b1-linolenic acid groups were significantly lower than that of the 50 mM glucose group(P<0.01);(2)the GSH level of three \u03b1-linolenic acid groups was significantly higher than that of the 50 mM glucose group(P<0.01);the GSSG levels of three \u03b1-linolenic acid groups were significantly lower than that of the 50 mM glucose group(P<0.01);(3) the labeled rates by FITC probe of three \u03b1-linolenic acid groups were significantly lower than that of the 50 mM glucose group(P<0.01);and(4) the erythrocyte shape of three \u03b1-linolenic acid groups and the PBS group was more normal that of the 50 mM glucose group.Conclusion ALA could protect the structure and function of erythrocytes,and then may have a preventive protection of diabetes and its complications.",
        "keywords": [
            "erythrocytes",
            "membrane",
            "diabetes",
            "\u03b1-linolenic acid",
            "antioxidation"
        ],
        "authors": [
            {
                "name": "ZHAO Yao-wu",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "FU Juan",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "ZHOU Shao-liang",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "YU Miao",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "YANG Wei",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "YU Dong",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "WANG Di",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "YAO Ping",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "LIU Lie-gang",
                "org": " Department of Nutrition and Food Hygiene,School of Public Health, Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            }
        ],
        "venue": "Jiangsu Journal of Preventive Medicine",
        "year": 2013
    },
    "ci5mPA7G": {
        "id": "ci5mPA7G",
        "title": "CARBON MONOXIDE PROTECTS MICROSOMES FROM ETHANOL-DERIVED OXIDATIVE STRESS MEDIATED BY CYP2E1",
        "abstract": "Objective To investigate the effect of carbon monoxide derived from hemeoxygenase-1(HO-1) metabolism on CYP2E1(cytochrome p4502E1) activity,and the protective role on ethanol-induced oxidative stress mediated by CYP2E1.Methods Liver microsomes isolated form Sprague-Dawley rat using ultracentrifugation technique,were treated with hemin,Hb or different dose of carbon monoxide-releasing molecule-2(CORM-2) and the catalytic activity of CYP2E1 was detected.In addition,the activity of superoxide dismutase(SOD),as well as the levels of glutathione(GSH),malondialdehyde(MDA) and reactive oxygen species(ROS) were assayed when incubated with hemin,Hb or CORM-2.Results Hemin treatment significantly inactivated CYP2E1,which was mimicked by CORM-2 in dose-dependent manner but blocked by Hb.Furthermore,hemin and CORM-2 evidently inhibited the increase of MDA and ROS,and the GSH depletion and SOD inactivation in microsomes induced by ethanol.Likewise,Hb abolished the protective effect of hemin and inactivated CORM-2 failed to exhibit any protective role.Conclusion Carbon monoxide prevented mcrosomes from ethnol-induced oxidative stress,which might be involved in its direct inhibition on CYP2E1.",
        "keywords": [
            "ethanol",
            "carbon monoxide",
            "liver microsomes",
            "hemeoxygenase-1",
            "CYP2E1"
        ],
        "authors": [
            {
                "name": "SHI Yan-ru",
                "org": "Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science &Technology,Wuhan ,China"
            },
            {
                "name": "TANG Yu-han",
                "org": "Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science &Technology,Wuhan ,China"
            },
            {
                "name": "GAO Chao",
                "org": "Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science &Technology,Wuhan ,China"
            },
            {
                "name": "WANG Di",
                "org": "Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science &Technology,Wuhan ,China"
            },
            {
                "name": "LIU Lie-gang",
                "org": "Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science &Technology,Wuhan ,China"
            },
            {
                "name": "YAO Ping",
                "org": "Department of Nutrition and Food Hygiene School of Public Health Tongji Medical College Huazhong University of Science &Technology,Wuhan ,China"
            }
        ],
        "venue": "Acta Nutrimenta Sinica",
        "year": 2012
    },
    "FIqGbqve": {
        "authors": [
            {
                "name": "P.C. Ng",
                "org": "Department of Paediatrics"
            },
            {
                "name": "T.F. Fok",
                "org": "Department of Paediatrics"
            },
            {
                "name": "F. Liu",
                "org": "Department of Paediatrics"
            },
            {
                "name": "C.H. Lee",
                "org": "Department of Paediatrics"
            },
            {
                "name": "K.C. Ma",
                "org": "Department of Paediatrics"
            },
            {
                "name": "E. Wong",
                "org": "Ctr. Clin. Trials Epidemiol. Res."
            }
        ],
        "title": "Effects of inhaled corticosteroids on systemic blood pressure in preterm infants",
        "abstract": "Objective: To assess the effect of inhaled fluticasone propionate on (i) systemic blood pressure, and (ii) the need for volume expanders (crystalloids and colloids) and inotropes for blood pressure support in preterm, very low birth weight (VLBW) infants. Methods: Ventilated VLBW infants, less than 32 weeks of gestation, with respiratory distress syndrome were randomised to receive a 14-day course of either fluticasone propionate (500 \u03bcg/puff, 2 puffs every 12 h; n = 27) or placebo (n = 26) with a metered dose inhaler-spacer device. The response of treatment was assessed by comparing the use of volume expanders, inotropes, and the average and the lowest systolic, mean and diastolic blood pressures in 6 hourly epochs between the 2 groups. Results: There were no significant differences in the average or the lowest systolic, mean and diastolic blood pressures in 6 hourly epochs between the 2 groups. However, the total volume of crystalloids and colloids requirement was significantly greater in control than in treated infants (p = 0.03). There was also a trend towards greater consumption of the total cumulative dose of dopamine in the control infants (p = 0.10). Conclusions: Fluticasone-treated infants required significantly less volume of crystalloids and colloids for blood pressure support compared with control infants. Further larger scale studies are required to determine whether inhaled corticosteroids could minimise the use of volume replacement therapy and inotropes in the treatment of hypotension in preterm infants in the early postnatal period. Copyright \u00a9 2004 S. Karger AG, Basel.",
        "keywords": [
            "Blood pressure",
            "Colloids",
            "Crystalloids",
            "Fluticasone, inhaled",
            "Preterm infants"
        ],
        "venue": "Biology of the Neonate",
        "year": 2004,
        "id": "FIqGbqve"
    },
    "dnoNdcPX": {
        "authors": [
            {
                "name": "P.C. Ng",
                "org": "Department of Paediatrics"
            },
            {
                "name": "H.L. Wong",
                "org": "Department of Paediatrics"
            },
            {
                "name": "D.J. Lyon",
                "org": "Department of Microbiology"
            },
            {
                "name": "K.W. So",
                "org": "Department of Paediatrics"
            },
            {
                "name": "F. Liu",
                "org": "Department of Paediatrics"
            },
            {
                "name": "R.K.Y. Lam",
                "org": "Department of Microbiology"
            },
            {
                "name": "E. Wong",
                "org": "Ctr. Clin. Trials Epidemiol. Res."
            },
            {
                "name": "A.F.B. Cheng",
                "org": "Department of Microbiology"
            },
            {
                "name": "T.F. Fok",
                "org": "Department of Paediatrics"
            }
        ],
        "title": "Combined use of alcohol hand rub and gloves reduces the incidence of late onset infection in very low birthweight infants",
        "abstract": "Objective: To assess the incidence of late onset (> 72 hours) infection and necrotising enterocolitis (NEC) in very low birthweight (VLBW) infants in two 36 month periods using two hand hygiene protocols: conventional handwashing (HW; first 36 month period); an alcohol hand rub and gloves technique (HR; second 36 month period). Method: VLBW infants admitted to the neonatal intensive care unit during the period December 1993-November 1999 were eligible. A new hand hygiene protocol using alcohol handrub and gloves was introduced in December 1996. Each patient's case record was reviewed retrospectively by two independent investigators using a standard data collection form. The incidence of NEC and systemic infections, including bacterial or fungal septicaemia, meningitis, and peritonitis, in the two periods were compared. Results: The HW and HR groups contained 161 and 176 VLBW infants respectively. The incidence of late onset systemic infection decreased from 13.5 to 4.8 episodes (including NEC)/1000 patient days after introduction of the HR regimen, representing a 2.8-fold reduction. Similarly, the incidence of Gram positive, Gram negative, and fungal infections decreased 2.5-fold, 2.6-fold, and 7-fold respectively. There was also a significant reduction in the incidence of NEC in the HR group (p < 0.0001). Subgroup analysis revealed that the incidence of methicillin resistant Staphylococcus aureus (MRSA) septicaemia was significantly decreased in the second 36 month period (p = 0.048). The clinical data suggest that infants in the HW group had significantly earlier onset of sepsis (p < 0.05) and required oxygen supplementation for longer (p < 0.05) than those in the HR group. Significantly more VLBW infants were discharged from the neonatal intensive care unit without ever being infected (p < 0.0001), and also significantly fewer infants had more than one episode of infection in the HR group (p < 0.0001). Conclusion: The introduction of the HR protocol was associated with a 2.8-fold reduction in the incidence of late onset systemic infection, and also a significant decrease in the incidence of MRSA septicaemia and NEC in VLBW infants. This decrease in infection rate was maintained throughout the second 36 month period.",
        "keywords": [
            ""
        ],
        "venue": "Archives of Disease in Childhood: Fetal and Neonatal Edition",
        "year": 2004,
        "id": "dnoNdcPX"
    },
    "WCBVI4X6": {
        "authors": [
            {
                "name": "Haohong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhirong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Junqian Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Changcang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Guangcan Xiao",
                "org": "Center of Analysis and Measurement"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Structure and self-assembly synthesis of a novel heterometallic one-dimensional coordination polymer: {[Cu(II)(DETA)I\u2022DMF] ",
        "abstract": "A novel organic-inorganic hybrid coordination polymer {[Cu(II)(DETA) I\u2022DMF]",
        "keywords": [
            "Cation template reagent",
            "Coordination polymers",
            "Lead iodide",
            "Organic-inorganic hybrid"
        ],
        "venue": "Journal of Chemical Crystallography",
        "year": 2006,
        "id": "WCBVI4X6"
    },
    "6rBgbEIt": {
        "authors": [
            {
                "name": "Zhen-Jie Zhang",
                "org": ""
            },
            {
                "name": "Wei Shi",
                "org": ""
            },
            {
                "name": "Yong-Quan Huang",
                "org": ""
            },
            {
                "name": "Bin Zhao",
                "org": ""
            },
            {
                "name": "Peng Cheng",
                "org": ""
            },
            {
                "name": "Dai-Zheng Liao",
                "org": ""
            },
            {
                "name": "Shi-Ping Yan",
                "org": ""
            }
        ],
        "title": "The self-assembly of a heteronuclear complex monitored with ESI-MS and fluorescence spectrophotometry",
        "abstract": "A strategy of separate steps was utilized to research the self-assembly of {[Tb",
        "keywords": [
            ""
        ],
        "venue": "CrystEngComm",
        "year": 2009,
        "id": "6rBgbEIt"
    },
    "UGi9HlON": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": ""
            },
            {
                "name": "Zhi-Rong Chen",
                "org": ""
            },
            {
                "name": "Jun-Qian Li",
                "org": ""
            },
            {
                "name": "Chang-Cang Huang",
                "org": ""
            },
            {
                "name": "Xiao-Lin Hu",
                "org": ""
            },
            {
                "name": "Bin Zhao",
                "org": ""
            },
            {
                "name": "Zhao-Xia Ni",
                "org": ""
            }
        ],
        "title": "Novel inorganic-organic hybrid coordination polymer [(C",
        "abstract": "A novel 1-D organic-inorganic silver(I)-iodide coordination architecture [(C",
        "keywords": [
            "Coordination polymers",
            "Optical limiting effect",
            "Organic-inorganic hybrid",
            "Template synthesis"
        ],
        "venue": "Journal of Cluster Science",
        "year": 2005,
        "id": "UGi9HlON"
    },
    "XNUJ2gkd": {
        "authors": [
            {
                "name": "Qing Yu",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Xiuqing Zhang",
                "org": "College of Chemistry"
            },
            {
                "name": "Hedong Bian",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Hong Liang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry"
            },
            {
                "name": "Shiping Yan",
                "org": "College of Chemistry"
            },
            {
                "name": "Daizheng Liao",
                "org": "College of Chemistry"
            }
        ],
        "title": "pH-dependent Cu(II) coordination polymers with tetrazole-1-acetic acid: Synthesis, crystal structures, EPR and magnetic properties",
        "abstract": "Four novel copper tetrazole-1-acetic acid (Htza) coordination polymers, namely, {[Cu(tza)",
        "keywords": [
            ""
        ],
        "venue": "Crystal Growth and Design",
        "year": 2008,
        "id": "XNUJ2gkd"
    },
    "RvFjSlm2": {
        "authors": [
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Long Yi",
                "org": "Department of Chemistry"
            },
            {
                "name": "Peng Cheng",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dai-Zheng Liao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shi-Ping Yan",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zong-Hui Jiang",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Hydrothermal synthesis, crystal structure and luminescent properties of 2d grid-like polymer based on 3d-4d mixed metals",
        "abstract": "The hydrothermal synthesis of V ",
        "keywords": [
            "3d-4d Heterometallic",
            "Coordination polymer",
            "Crystal structure",
            "Hydrothermal synthesis"
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2004,
        "id": "RvFjSlm2"
    },
    "kwheg4NF": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "Department of Chemistry"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Rong-Ping Xiao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zhao-Xia Ni",
                "org": "Department of Chemistry"
            }
        ],
        "title": "The self-assembly synthesis and structure of a novel 1-D lead iodide adduct: [(Pb",
        "abstract": "The lead iodide adduct [(Pb",
        "keywords": [
            "Coordination polymers",
            "Lead iodide",
            "Organic-inorganic hybrid",
            "X-ray single crystal structure"
        ],
        "venue": "Chinese Journal of Inorganic Chemistry",
        "year": 2005,
        "id": "kwheg4NF"
    },
    "z9y5Pdie": {
        "authors": [
            {
                "name": "Hong-Sheng Wang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Bin Zhai",
                "org": "Department of Chemistry"
            },
            {
                "name": "Wei Shi",
                "org": "Department of Chemistry"
            },
            {
                "name": "Peng Cheng",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dai-Zheng Liao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shi-Ping Yan",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Syntheses, structures, and photoluminescence of one-dimensional lanthanide coordination polymers with 2,4,6-pyridinetricarboxylic acid",
        "abstract": "Nine one-dimensional (ID) lanthanide(III) coordination polymers with the formulas {[La(pta)(H",
        "keywords": [
            ""
        ],
        "venue": "Crystal Growth and Design",
        "year": 2007,
        "id": "z9y5Pdie"
    },
    "iJ3JFLGt": {
        "authors": [
            {
                "name": "Xiao-Yan Chen",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jun Xia",
                "org": "Department of Chemistry"
            },
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Peng Cheng",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shi-Ping Yan",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dai-Zheng Liao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zong-Hui Jiang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Hai-Bin Song",
                "org": "State Key Lab. Elemento-Organ. Chem."
            },
            {
                "name": "Hong-Gen Wang",
                "org": "State Key Lab. Elemento-Organ. Chem."
            }
        ],
        "title": "A macrocyclic chromium(III) complex with mixed hydroxo and carbonato bridges: Crystal structure and magnetic properties of [(tacn)Cr(\u03bc-OH) ",
        "abstract": "A novel homodinuclear complex [(tacn)Cr(\u03bc-OH)",
        "keywords": [
            "1,4,7-Triazacyclononane",
            "Chromium(III) complex",
            "Crystal structure",
            "Magnetic properties"
        ],
        "venue": "Journal of Coordination Chemistry",
        "year": 2004,
        "id": "iJ3JFLGt"
    },
    "5XW3l6CQ": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": ""
            },
            {
                "name": "Cang Wang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Yong-Gang Ren",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Jun-Qian Li",
                "org": "State Key Laboratory of Structural Chemistry"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "A novel platinum(IV) halide anion as ethyl-triphenylphosphenonium salt: Synthetic, structural and theoretical study",
        "abstract": "A novel platinum(IV) complex [Ph",
        "keywords": [
            "DFT calculation",
            "Ethyl-triphenylphosphenonium",
            "Platinum(IV) complexes"
        ],
        "venue": "Jiegou Huaxue",
        "year": 2005,
        "id": "5XW3l6CQ"
    },
    "inlqb3nK": {
        "authors": [
            {
                "name": "Wei Shi",
                "org": "Department of Chemistry"
            },
            {
                "name": "Xiao-Yan Chen",
                "org": "Department of Chemistry"
            },
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Ao Yu",
                "org": "Department of Chemistry"
            },
            {
                "name": "Hai-Bin Song",
                "org": "Department of Chemistry"
            },
            {
                "name": "Peng Cheng",
                "org": "Department of Chemistry"
            },
            {
                "name": "Hong-Gen Wang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dai-Zheng Liao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shi-Ping Yan",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Construction of 3d-4f mixed-metal complexes based on a binuclear oxovanadium unit: Synthesis, crystal structure, EPR, and magnetic properties",
        "abstract": "The oxovanadium(IV)-lanthanide(III) heteronuclear complexes, {[Ce(H ",
        "keywords": [
            ""
        ],
        "venue": "Inorganic Chemistry",
        "year": 2006,
        "id": "inlqb3nK"
    },
    "3iVRkv4S": {
        "authors": [
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Long Yi",
                "org": "Department of Chemistry"
            },
            {
                "name": "Yan Dai",
                "org": "Department of Chemistry"
            },
            {
                "name": "Xiao-Yan Chen",
                "org": "Department of Chemistry"
            },
            {
                "name": "Peng Cheng",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dai-Zheng Liao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shi-Ping Yan",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zong-Hui Jiang",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Systematic investigation of the hydrothermal syntheses of Pr(III)-PDA (PDA = pyridine-2,6-dicarboxylate anion) metal-organic frameworks",
        "abstract": "A series of novel two-dimensional (2D) and three-dimensional (3D) praseodymium coordination polymers, namely, {[Pr",
        "keywords": [
            ""
        ],
        "venue": "Inorganic Chemistry",
        "year": 2005,
        "id": "3iVRkv4S"
    },
    "9DMmOZis": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Jun-Qian Li",
                "org": "State Key Laboratory of Structural Chemistry"
            },
            {
                "name": "Hong-Bing Zhan",
                "org": "College of Materials Science and Engineering"
            },
            {
                "name": "Wen-Xuan Zhang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Cheng Ma",
                "org": "Department of Materials Science and Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Synthesis, structure and optical limiting effect of a novel inorganic-organic hybrid polymer containing mixed chains of copper(I)/iodine",
        "abstract": "In this paper, treatment of N-ethyl-benzo[f]quinolium (ebq) iodide and CuI with excess KI afforded an unusual coordination polymer [(ebq)",
        "keywords": [
            "Coordination polymers",
            "copper(I) iodide",
            "optical limiting effect",
            "organic-inorganic hybrid"
        ],
        "venue": "Journal of Solid State Chemistry",
        "year": 2006,
        "id": "9DMmOZis"
    },
    "7tz1YJQq": {
        "authors": [
            {
                "name": "Yong-Gang Ren",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Jun-Qian Li",
                "org": "State Key Laboratory of Structural Chemistry"
            }
        ],
        "title": "Synthesis, crystal structure and quantum chemistry calculation of a bis(dafone) di(dmf) copper(II) complex",
        "abstract": "The title compound [Cu(dafone)",
        "keywords": [
            "Cu(II) complexes",
            "Dafone",
            "Quantum calculation",
            "Unsymmetric chelation"
        ],
        "venue": "Jiegou Huaxue",
        "year": 2005,
        "id": "7tz1YJQq"
    },
    "44csK8SH": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jun-Qian Li",
                "org": "Department of Chemistry"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zhao-Xia Ni",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Lewis-base adducts of lead(II) compounds: Synthesis, structure and quantum chemistry calculation of mononuclear Pb(phen)(SCN)",
        "abstract": "The lead thiocyanate adduct Pb(phen)(SCN)",
        "keywords": [
            ""
        ],
        "venue": "Jiegou Huaxue",
        "year": 2005,
        "id": "44csK8SH"
    },
    "U9zCVwxU": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Jun-Qian Li",
                "org": "State Key Laboratory of Structural Chemistry"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Guang-Can Xiao",
                "org": "Center of Analysis and Measurement"
            },
            {
                "name": "Xiao-Lin Hu",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Fu-Xian Xiao",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Novel organic-inorganic hybrid coordination polymer [(DBU-H)(PbI ",
        "abstract": "The coordination polymer [(DBU-H)(PbI",
        "keywords": [
            "Lead(II) iodide",
            "Organic-inorganic hybrid",
            "Quantum chemical calculation",
            "Template synthesis"
        ],
        "venue": "Chinese Journal of Chemistry",
        "year": 2005,
        "id": "U9zCVwxU"
    },
    "KCdpEvdA": {
        "authors": [
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Yong-Gang Ren",
                "org": ""
            },
            {
                "name": "Jun-Qian Li",
                "org": "State Key Laboratory of Structural Chemistry"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Synthesis, structure and DFT investigation into a copper(II) compound consisting of 4,7-diphenyl-1,10-phentheanthroline",
        "abstract": "The copper(II) DPP adduct Cu(DPP)(DMF)",
        "keywords": [
            "4,7-diphenyl-1,10-phentheanthroline",
            "Cu(II) complexes",
            "DFT calculation"
        ],
        "venue": "Jiegou Huaxue",
        "year": 2005,
        "id": "KCdpEvdA"
    },
    "vh6Pu90E": {
        "authors": [
            {
                "name": "Rui-Feng Zhang",
                "org": "Center of Analysis and Test"
            },
            {
                "name": "Bin Zhao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Hong-Sheng Wang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Peng Cheng",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Two novel 2-D homometallic cyano-bridged complexes: Synthesis, structures and fluorescent properties",
        "abstract": "Synthesis, structure and photoluminescent properties of two novel 2-D cyano-bridged complexes {[M",
        "keywords": [
            "Cadmium complex",
            "Cyano-bridged",
            "Photoluminescent property",
            "Zinc complex"
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2007,
        "id": "vh6Pu90E"
    },
    "jg0QZY83": {
        "authors": [
            {
                "name": "Ling-Guo Sun",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Jun-Qian Li",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Synthesis and structure of a novel quasi-two dimensional organic-inorganic hybrid coordination polymer:{[Cu(en)",
        "abstract": "A novel coordination polymer {[Cu(en)",
        "keywords": [
            "Coordination polymer",
            "Iodide",
            "Single-crystal diffraction",
            "Template synthesis"
        ],
        "venue": "Jiegou Huaxue",
        "year": 2006,
        "id": "jg0QZY83"
    },
    "l3BqKbP6": {
        "authors": [
            {
                "name": "Bin Zhao",
                "org": ""
            },
            {
                "name": "Peng Cheng",
                "org": ""
            },
            {
                "name": "Yan Dai",
                "org": ""
            },
            {
                "name": "Cai Cheng",
                "org": ""
            },
            {
                "name": "Dai-Zheng Liao",
                "org": ""
            },
            {
                "name": "Shi-Ping Yan",
                "org": ""
            },
            {
                "name": "Zong-Hui Jiang",
                "org": ""
            },
            {
                "name": "Geng-Lin Wang",
                "org": ""
            }
        ],
        "title": "A nanotubular 3D coordination polymer based on a 3d-4f heterometallic assembly",
        "abstract": "Large pores comprising 48-membered rings characterize the isostructural lanthanide-transition-metal coordination polymers [{[Ln(dipic)",
        "keywords": [
            "Coordination polymers",
            "Lanthanides",
            "Self-assembly",
            "Transition metals",
            "Zeolite analogues"
        ],
        "venue": "Angewandte Chemie - International Edition",
        "year": 2003,
        "id": "l3BqKbP6"
    },
    "gEZBr6Bu": {
        "authors": [
            {
                "name": "Zi-Hou Ke",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Zhi-Rong Chen",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Hao-Hong Li",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Chang-Cang Huang",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Guang-Can Xiao",
                "org": "Central Laboratory"
            },
            {
                "name": "Bin Zhao",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Synthesis and structure of Ag(I)-containing coordination polymers based on quaternary ammonium template reagent",
        "abstract": "A novel coordination polymer [(C",
        "keywords": [
            "Coordination polymers",
            "Iodide",
            "Quaternary ammonium",
            "Template synthesis"
        ],
        "venue": "Jiegou Huaxue",
        "year": 2005,
        "id": "gEZBr6Bu"
    },
    "FxRFOfpm": {
        "id": "FxRFOfpm",
        "title": "Predicting Lean Blowout Limit of Combustors Based on Semi-Empirical Correlation and Simulation",
        "abstract": "A method named characteristic curve of flame volume is achieved for lean blowout predictions on the basis of the improved Lefebvre\u2019s model and simulated reacting flows. Three main issues are presented: 1)\u00a0Based on the results from combustion visualization experiments, Lefebvre\u2019s model is improved regarding its universality for combustor configurations. The flame volume near lean blowout Vflame,LBO obtained from simulated reacting flow is introduced into the model. 2)\u00a0Characteristic curve of flame volume is a functional curve of flame volume Vflame and fuel/air ratio q in a certain combustor and is presented as an \u201cS\u201d pattern, with q ranging from stable operation to nearly engine-off conditions. The region where the fuel/air ratio ranges from 3 to 10 in characteristic curve of flame volume is the unstable combustion region, and nearly all of the lean blowout points fall in this region. 3)\u00a0According to the relationship between characteristic curve of flame volume expressed as q=f(Vflame) and the improved Le...",
        "keywords": [],
        "authors": [
            {
                "name": "bin hu",
                "org": ""
            },
            {
                "name": "qingjun zhao",
                "org": ""
            },
            {
                "name": "jianzhong xu",
                "org": ""
            }
        ],
        "venue": "Journal of Propulsion and Power",
        "year": 2015
    },
    "GGv4rUJl": {
        "id": "GGv4rUJl",
        "title": "Predicting lean blow-off of bluffbody stabilized flames based on Damk\u00f6hler number",
        "abstract": "Abstract   Lean Blow-Off (LBO) prediction is important to propulsion system design. In this paper, a hybrid method combining numerical simulation and  Da  (Damkohler) model is proposed based on bluffbody stabilized flames. In the simulated reacting flow, Practical Reaction Zone (PRZ) is built based on OH radical concentration, and it is considered to be the critical zone that controls LBO.  Da  number is obtained based on the volume-averaged parameters of PRZ. The flow time scale ( \u03c4  f ) indicates the residence time of the fresh mixture flowing through the PRZ. It is obtained based on the characteristic length and volume-averaged axial velocity of the PRZ. The chemical time scale ( \u03c4  c ) indicates the shortest time needed to trigger the reaction of the mixture. It is obtained by commercial software CHEMKIN through monitoring the transient variation of the reactor temperature. The result shows that the average  Da  number under different LBO conditions is 1.135 (the  Da  number under each LBO condition ranges from 0.673 to 1.351). This indicates that the flow time scale and chemical time scale are comparable. The combustion is in a critical state where LBO is easy to occur. With the increase of the fuel mass flow rate (the global fuel/air ratio increases from 0.004761 to 0.01095),  \u03c4  f  increases from 0.001268\u202fs to 0.007249\u202fs, and  \u03c4  c  decreases from 0.00124\u202fs to 0.00089\u202fs. Accordingly,  Da  number increases from 1.023 to 8.145, which shows that the combustion becomes more stable. The above results show that the method proposed in the present study can properly predict the LBO limits of combustors, which provides important technical supports for combustor design and optimization.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhonghao Wang",
                "org": ""
            },
            {
                "name": "Bin Hu",
                "org": ""
            },
            {
                "name": "Aiming Deng",
                "org": ""
            },
            {
                "name": "Junhua Zhang",
                "org": ""
            },
            {
                "name": "Qingjun Zhao",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Aeronautics",
        "year": 2019
    },
    "gYiRwCkw": {
        "id": "gYiRwCkw",
        "title": "A Hybrid Semi-empirical Model for Lean Blow-Out Limit Predictions of Aero-engine Combustors",
        "abstract": "",
        "keywords": [
            "combustion chambers",
            "computer simulation"
        ],
        "authors": [
            {
                "name": "bin hu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "yong huang",
                "org": "beihang university"
            },
            {
                "name": "jianzhong xu",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Engineering for Gas Turbines and Power-transactions of The Asme",
        "year": 2015
    },
    "CVPqgk2p": {
        "authors": [
            {
                "name": "Lei Zhu",
                "org": ""
            },
            {
                "name": "Wengui Xu",
                "org": ""
            },
            {
                "name": "Xiang Zhu",
                "org": ""
            },
            {
                "name": "Xiuyu Song",
                "org": ""
            },
            {
                "name": "Dong Dai",
                "org": ""
            },
            {
                "name": "Yanjia Zhu",
                "org": ""
            },
            {
                "name": "Zhiyong Yuan",
                "org": ""
            }
        ],
        "title": "Clinical value of PET/CT in evaluation of the effect of cyberknife on lung cancer and metastases",
        "abstract": "Objective: To explore the clinical value of PET/CT in assessing the effect of Cyberknife on lung cancer and metastases. Methods: A total of 23 lung cancer patients in our hospital were studied with PET/ CT scans before and after radiotherapy using Cyberknife. Change and analysis in maximum standard uptake value (SUVmax) was correlated with the size (sum of maximum diameters Dmax) of all neoplastic focus before and after radiotherapy using Cyberknife. Results: There was a significant reduction in both SUVmax and Dmax of all neoplastic focus after radiotherapy using Cyberknife (P<0.05). The mean percentage metabolic change AM was significantly larger than that of size change A\u00ae (64.93\u00b123.60% vs 32.50\u00b157.04%). The efficient ratios of PET, CT and PET/CT imaging methods in evaluating radiotherapeutic effect of Cyberknife were 94.29%, 54.29% and 97.14%, respectively. The change rate of glucose metabolism (AM) and morphological change rate (A\u00ae) were (64.93\u00b123.60) % and (32.50\u00b157.04). The effective rates of Cyberknife evaluated with PET, CT, and PET were 94.29%, 54.29%, and 97.14%, respectively. The consistency of glucose metabolism (AM) and morphological change rate (Act)) in evaluating the effect of Cyberknife was 54.29% (19/35). Among the two methods, the sensitivity and accuracy of PET (SUVmax) were 97.01% and 97.14%, respectively, and the corresponding values of CT (Dmax) were 55.89% and 57.14%, respectively. Conclusion: PET/CT or PET alone is more sensitive and accurate in assessing therapeutic response than CT.",
        "keywords": [
            "Lung neoplasms",
            "Positron emission tomography/computer tomography",
            "Radiotherapy",
            "Standardized uptake values"
        ],
        "venue": "Chinese Journal of Clinical Oncology",
        "year": 2009,
        "id": "CVPqgk2p"
    },
    "UPh6KHAk": {
        "authors": [
            {
                "name": "Xiu-Xia Xu",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Juan Cheng",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Wen-Gui Xu",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Dong Dai",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Xiu-Yu Song",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Wen-Chao Ma",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Lei Zhu",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            },
            {
                "name": "Xiang Zhu",
                "org": "Department of Molecule Imaging and Nuclear Medicine in Diagnosis and Treatment"
            }
        ],
        "title": "Value of dual-time-point 18F-fluorodeoxyglucose integrated positron emission and computed tomography in differentiation of malignant from benign gastrointestinal diseases",
        "abstract": "Objective: To explore the value of dual-time-point ",
        "keywords": [
            "Deoxyglucose",
            "Diagnosis, differential",
            "Gastrointestinal diseases",
            "Gastrointestinal neoplasms",
            "Tomography, emission-computed"
        ],
        "venue": "Chinese Journal of Oncology",
        "year": 2012,
        "id": "UPh6KHAk"
    },
    "gkLVbqGj": {
        "authors": [
            {
                "name": "Ning-Bo Liu",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Lei Zhu",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Ming-Huan Li",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Xiao-Rong Sun",
                "org": "Department of Nuclear Medicine"
            },
            {
                "name": "Man Hu",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Zong-Wei Huo",
                "org": "PET/CT Center of Shandong Cancer Hospital"
            },
            {
                "name": "Wen-Gui Xu",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Jin-Ming Yu",
                "org": "Department of Radiation Oncology"
            }
        ],
        "title": "Diagnostic value of ",
        "abstract": "Purpose: To evaluate the diagnostic value of ",
        "keywords": [
            "18F-FDG",
            "Bbone scintigraphy -CT",
            "Bone metastasis",
            "PET-CT"
        ],
        "venue": "Asian Pacific Journal of Cancer Prevention",
        "year": 2013,
        "id": "gkLVbqGj"
    },
    "jRt22mhA": {
        "authors": [
            {
                "name": "Dong Dai",
                "org": "Department of Molecular Imaging and Nuclear Medicine"
            },
            {
                "name": "Wengui Xu",
                "org": "Department of Molecular Imaging and Nuclear Medicine"
            },
            {
                "name": "Jianjing Liu",
                "org": "Department of Molecular Imaging and Nuclear Medicine"
            },
            {
                "name": "Lei Zhu",
                "org": "Department of Molecular Imaging and Nuclear Medicine"
            },
            {
                "name": "Xiang Zhu",
                "org": "Department of Molecular Imaging and Nuclear Medicine"
            },
            {
                "name": "Xiaoying Ma",
                "org": "Department of Molecular Imaging and Nuclear Medicine"
            }
        ],
        "title": "Safety and efficacy of a peripheral intravenous bolus of Licartin for the treatment of advanced hepatocellular carcinoma",
        "abstract": "The aim of the present study was to examine the safety and efficacy of a peripheral intravenous bolus of Licartin for the treatment of advanced hepatocellular carcinoma (HCC), and to explore the clinical value of this treatment. Clinical data from Tianjin Medical University Cancer Institute and Hospital (Tianjin, China) were analyzed. Thirty-three patients (38 cases) with advanced HCC received an intravenous bolus of Licartin. The patients underwent routine blood examinations and liver, kidney and thyroid function tests 1 week prior to treatment and 1 and 3 months after treatment, and a long-term follow-up was performed. These data were collected before and after treatment was statistically analyzed and compared with that of previous studies regarding the safety of Licartin combined with transcatheter arterial chemoembolization for the treatment of HCC. During treatment, adverse reactions, including non-infectious fever, pain in the liver area, nausea and vomiting, occurred in a minority of patients. The adverse reactions were endured in the majority of cases and the symptoms were spontaneously relieved. Following treatment, 15 patients (39.47% of cases) demonstrated drug-related adverse reactions, including decreased white blood cell counts, platelet counts, hemoglobin levels and neutrophil counts, and increased levels of alanine aminotransferase, aspartate aminotransferase, serum direct bilirubin, creatinine and blood urea nitrogen, from high to low incidence. Electrocardiograms indicated no significant differences in thyroid function between patients before and after treatment, and showed stable vital signs. This study demonstrated that peripheral intravenous bolus administration of Licartin for radioimmunotherapy is safe and effective, is tolerated by the patient and may potentially become a routine treatment for HCC.",
        "keywords": [
            "Hepatocellular carcinoma",
            "Licartin",
            "Radioimmunotherapy",
            "Safety"
        ],
        "venue": "Experimental and Therapeutic Medicine",
        "year": 2013,
        "id": "jRt22mhA"
    },
    "dJcZJyBO": {
        "authors": [
            {
                "name": "Wenchao Ma",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Wengui Xu",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Xiang Zhu",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Jian Wang",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Dong Dai",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Xiuyu Song",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Lei Zhu",
                "org": "Tianjin Medical University"
            },
            {
                "name": "Yanjia Zhu",
                "org": "Tianjin Medical University"
            }
        ],
        "title": "Diagnostic value of qualitative and quantitative analysis by 18F-FDG PET/CT for mediastinal lymph nodes of lung cancer",
        "abstract": "Objective: To discuss the diagnostic value of qualitative and quantitative analysis by ",
        "keywords": [
            "18F-fdg",
            "Lung cancer",
            "Mediastinal lymph node",
            "PET/CT",
            "Qualitative and quantitative analysis"
        ],
        "venue": "Chinese Journal of Clinical Oncology",
        "year": 2011,
        "id": "dJcZJyBO"
    },
    "t0jB4Wt7": {
        "authors": [
            {
                "name": "Xiao-Yi Yang",
                "org": "Department of Molecule Image and Nuclear Medicine to Diagnose and Treat"
            },
            {
                "name": "Xiu-Xia Xu",
                "org": "Department of Molecule Image and Nuclear Medicine to Diagnose and Treat"
            },
            {
                "name": "Wen-Gui Xu",
                "org": "Department of Molecule Image and Nuclear Medicine to Diagnose and Treat"
            },
            {
                "name": "Dong Dai",
                "org": "Department of Molecule Image and Nuclear Medicine to Diagnose and Treat"
            },
            {
                "name": "Lei Zhu",
                "org": "Department of Molecule Image and Nuclear Medicine to Diagnose and Treat"
            }
        ],
        "title": "Diagnostic value of 18F-FDG PET/CT semi-quantitative analysis for cervical lymph node metastases",
        "abstract": "Objective: To explore the diagnostic value of ",
        "keywords": [
            "Fluorodeoxyglucose F18",
            "Lymph nodes",
            "Neoplasm metastasis",
            "Positron-emission tomography",
            "Tomography, X-ray computed"
        ],
        "venue": "Chinese Journal of Medical Imaging Technology",
        "year": 2012,
        "id": "t0jB4Wt7"
    },
    "AnMYC4FD": {
        "authors": [
            {
                "name": "Xi Liu",
                "org": "Department of Radiology, West China Hospital"
            },
            {
                "name": "Zhi-Gang Yang",
                "org": "Department of Radiology, West China Hospital"
            },
            {
                "name": "Si-Shi Tang",
                "org": "Department of Radiology, West China Hospital"
            },
            {
                "name": "Jing Chen",
                "org": "Department of Radiology, West China Hospital"
            },
            {
                "name": "Ling-Yi Wen",
                "org": "Department of Radiology, West China Hospital"
            },
            {
                "name": "Shuai Zhang",
                "org": "Department of Radiology, West China Hospital"
            }
        ],
        "title": "Characteristics of mediastinal lymph nodes enlargement determined by contrast-enhanced multi-detector CT in patients with sarcoidosis",
        "abstract": "Objective To determine the enhancement patterns and anatomic distribution of enlarged mediastinal lymph nodes using contrast-enhanced multi-detector CT (MDCT) in patients with sarcoidosis. Methods We reviewed the contrast-enhanced MDCT features of 39 patients with pathologically or clinically diagnosed sarcoidosis, including the size, morphology, attenuation, enhancement patterns, and anatomic distribution of the enlarged mediastinal lymph nodes. Results Of the 39 patients, 85% showed homogenous enhancement and 15% showed homogenous mixed with peripheral enhancement. The enlarged lymph nodes were predominantly distributed in the regions of 10R (95%), 10L (90%), 2R (69%), 7 (69%), and 5 (58%). Conclusion Contrast-enhanced MDCT can detect the enhancement patterns and predominant anatomic distribution of enlarged mediastinal lymph nodes, which is of great value for the diagnosis of sarcoidosis.",
        "keywords": [
            "Contrast-enhanced scanning",
            "Mediastinal lymph nodes",
            "Multi-detector computed tomography (MDCT)",
            "Sarcoidosis"
        ],
        "venue": "Journal of Sichuan University (Medical Science Edition)",
        "year": 2014,
        "id": "AnMYC4FD"
    },
    "Kas0C2po": {
        "authors": [
            {
                "name": "Hua-Yan Xu",
                "org": ""
            },
            {
                "name": "Zhi-Gang Yang",
                "org": ""
            },
            {
                "name": "Jia-Yu Sun",
                "org": ""
            },
            {
                "name": "Ling-Yi Wen",
                "org": ""
            },
            {
                "name": "Ge Zhang",
                "org": ""
            },
            {
                "name": "Shuai Zhang",
                "org": ""
            },
            {
                "name": "Ying-Kun Guo",
                "org": ""
            }
        ],
        "title": "The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy patients with or without left ventricular outflow tract obstruction: Assessment with first-pass perfusion imaging using 3.0-T cardiac magnetic resonance",
        "abstract": "Purpose To assess regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction using 3.0-T cardiac magnetic resonance (CMR) first-pass perfusion imaging. Materials and methods Forty-two HCM patients, including 25 HCM patients with left ventricular outflow tract obstruction (HOCM), 17 HCM patients without left ventricular outflow tract obstruction (NOHCM), and 14 healthy subjects underwent CMR. The left ventricular (LV) function, left ventricular end-diastolic wall thickness (EDTH), and diameter of left ventricular outflow tract (LVOT) were measured and calculated. Based on the signal-time curve of the first-pass myocardium perfusion imaging, perfusion parameters including upslope, time to peak, and peak intensity, were assessed and compared by using one-way analysis of variance and independent t tests. Results On the first-pass perfusion imaging, lower upslope and peak intensity and longer time to peak were found in HCM patients compared with normal subjects (all p < 0.05). In contrast to the NOHCM group, the average time to peak of the HOCM group was increased (13.30 \u00b1 4.82 s vs 16.28 \u00b1 4.90 s, p < 0.05), but first-pass perfusion upslope was reduced (4.96 \u00b1 2.55 vs 2.58 \u00b1 0.77, p < 0.05). According to the bull's-eye model, the HOCM group's average thickness of basal segments was thicker than the NOHCM group, especially the anteroseptal, inferolateral, and anterior wall values, with a corresponding lower first-pass perfusion upslope than the NOHCM group (all p < 0.05). A significant correlation was observed between first-pass perfusion upslope and LV EDTH (r = -0.551, p < 0.001) and LVOT diameter (r = 0.472, p < 0.001). Conclusions The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction can be detected with first-pass perfusion CMR imaging. \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.",
        "keywords": [
            "Hypertrophic cardiomyopathy",
            "Left Ventricular Outflow Tract Obstruction",
            "MRI",
            "Perfusion Imaging"
        ],
        "venue": "European Journal of Radiology",
        "year": 2014,
        "id": "Kas0C2po"
    },
    "VaQ7JE0e": {
        "authors": [
            {
                "name": "M. Xie",
                "org": ""
            },
            {
                "name": "S.S. Hou",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            }
        ],
        "title": "Methionine requirements of male White Peking ducks from twenty-one to forty-nine days of age",
        "abstract": "A dose-response experiment with 6 dietary methionine levels (0.20, 0.275, 0.35, 0.425, 0.50, and 0.575%) was conducted with male White Peking ducklings to estimate the methionine requirement of growing ducks from 21 to 49 d of age. One-day-old male White Peking ducklings were fed common starter diets from hatching to 21 d of age and then fed the experimental diets from 21 to 49 d of age. Three hundred thirty-six 21-d-old birds were allotted to 24 pens with 14 birds per pen according to similar pen weight. There were 6 dietary treatments, each containing 4 replicate pens. At 49 d of age, weight gain, feed intake, and feed/gain of ducks from each pen were measured, and 2 ducks selected randomly from each pen were slaughtered to evaluate the yields of abdominal fat, breast meat (including pectoralis major and pectoralis minor), and leg meat (including thigh and drum stick). Significant effects of dietary methionine on weight gain, breast meat, and abdominal fat were observed. Both weight gain and breast meat yield showed significant quadratic response to increasing dietary methionine, and abdominal fat decreased linearly (P < 0.05). According to the quadratic model, the optimal methionine requirement of male White Peking ducks from 21 to 49 d of age for maximum weight gain and breast meat yield were 0.377 and 0.379%, respectively. \u00a92006 Poultry Science Association, Inc.",
        "keywords": [
            "Duck",
            "Methionine",
            "Requirement"
        ],
        "venue": "Poultry Science",
        "year": 2006,
        "id": "VaQ7JE0e"
    },
    "JMuo7lpK": {
        "authors": [
            {
                "name": "Z.H. Zhang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Z.M. Niu",
                "org": "Chinese National Human Genome Centre"
            },
            {
                "name": "W.T. Yuan",
                "org": "Chinese National Human Genome Centre"
            },
            {
                "name": "J.J. Zhao",
                "org": "Institute of Dermatology"
            },
            {
                "name": "F.X. Jiang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "J. Zhang",
                "org": "Chinese National Human Genome Centre"
            },
            {
                "name": "B. Chai",
                "org": "Institute of Dermatology"
            },
            {
                "name": "F. Cui",
                "org": "Institute of Dermatology"
            },
            {
                "name": "W. Chen",
                "org": "Institute of Dermatology"
            },
            {
                "name": "C.H. Lian",
                "org": "Institute of Dermatology"
            },
            {
                "name": "L.H. Xiang",
                "org": "Department of Dermatology"
            },
            {
                "name": "S.J. Xu",
                "org": "Chinese National Human Genome Centre"
            },
            {
                "name": "W.D. Liu",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Z.Z. Zheng",
                "org": "Department of Dermatology"
            },
            {
                "name": "W. Huang",
                "org": "Institute of Dermatology"
            }
        ],
        "title": "A mutation in SART3 gene in a Chinese pedigree with disseminated superficial actinic porokeratosis",
        "abstract": "Background: Disseminated superficial actinic porokeratosis (DSAP) is an uncommon autosomal dominant chronic disorder of keratinization, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border. Thus far, although two loci for DSAP have been identified, and the genetic basis and pathogenesis of this disorder have not been elucidated. Objectives: To determine the locus of DSAP and identify the candidate gene(s) of the disease. Methods: Genome-wide scan and linkage analysis were performed in a six-generation Chinese family with DSAP. The coding exons of the candidate genes were sequenced to analyse and detect the nucleotide variations. Results: Linkage analysis showed that the maximum two-point lod score of 5-56 was obtained with the marker D12S79 at a recombination fraction \u03b8 of 0-00. Haplotype analysis defined the critical region for DSAP between D12S330 and D12S1612 on 12q24.1-24.2. By sequence analysis, we found a Val591Met mutation in SART3 in all affected individuals of the family. Conclusion: SART3 is a candidate gene for DSAP, and is possibly involved in the pathogenesis of DSAP. \u00a9 2005 British Association of Dermatologists.",
        "keywords": [
            "Disseminated superficial actinic porokeratosis (DSAP)",
            "Genome-wide scan",
            "Linkage analysis",
            "Mutation detection"
        ],
        "venue": "British Journal of Dermatology",
        "year": 2005,
        "id": "JMuo7lpK"
    },
    "qOl3wHw5": {
        "authors": [
            {
                "name": "X. Chu",
                "org": "Human Genetics Center"
            },
            {
                "name": "C. Dong",
                "org": "Department of Genetics"
            },
            {
                "name": "R. Lei",
                "org": "Ruijin Hospital"
            },
            {
                "name": "L. Sun",
                "org": "Department of Genetics"
            },
            {
                "name": "Z. Wang",
                "org": "Department of Genetics"
            },
            {
                "name": "Y. Dong",
                "org": "Department of Endocrinology"
            },
            {
                "name": "M. Shen",
                "org": "Department of Genetics"
            },
            {
                "name": "Y. Wang",
                "org": "Department of Genetics"
            },
            {
                "name": "B. Wang",
                "org": "Department of Genetics"
            },
            {
                "name": "K. Zhang",
                "org": "Department of Genetics"
            },
            {
                "name": "L. Yang",
                "org": "Department of Genetics"
            },
            {
                "name": "Y. Li",
                "org": "Department of Genetics"
            },
            {
                "name": "W. Yuan",
                "org": "Department of Genetics"
            },
            {
                "name": "Y. Wang",
                "org": "Department of Genetics"
            },
            {
                "name": "H. Song",
                "org": "Department of Genetics"
            },
            {
                "name": "L. Jin",
                "org": "Ruijin Hospital"
            },
            {
                "name": "M. Xiong",
                "org": "State Key Laboratory of Genetic Engineering"
            },
            {
                "name": "W. Huang",
                "org": "Department of Genetics"
            }
        ],
        "title": "Polymorphisms in the interleukin 3 gene show strong association with susceptibility to Graves' disease in Chinese population",
        "keywords": [
            ""
        ],
        "venue": "Genes and Immunity",
        "year": 2009,
        "id": "qOl3wHw5"
    },
    "paS3viM7": {
        "authors": [
            {
                "name": "J. Wang",
                "org": "State Key Laboratory of Animal Nutrition Science"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition Science"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition Science"
            },
            {
                "name": "X.G. Yang",
                "org": "College of Life Science and Chemistry"
            },
            {
                "name": "X.Y. Zhu",
                "org": "Yangtze River Fisheries Research Institute"
            },
            {
                "name": "X.L. Liu",
                "org": "College of Animal Science and Technology"
            }
        ],
        "title": "Molecular cloning of prolactin receptor of the Peking duck",
        "abstract": "Prolactin receptor (PRLR) cDNA of Peking duck was cloned using reverse transcription-PCR methodology (GenBank accession no. EF502054). The duck PRLR (dPRLR) cDNA contains 2,439 bp including the ATG start codon and TAA stop that encodes 832 amino acid residues. The putative receptor protein had 2 strong hydrophobic stretches: one was the signal sequence in N-terminal region and the other was the single transmembrane region of 24 amino acid residues in the central portion. Excluding the signal sequence, the mature dPRLR contained 808 amino acid residues with a theoretical molecular mass of 91.5 kDa. The ma-ture protein could be divided into 3 domains, extracellular domain (ECD), transmembrane domain, and intracellular domain. The ECD contained 2 homologous repeat units with ~67% amino acid sequence identity to each other. The membrane distal unit and proximal unit consisted of 204 and 212 amino acids, respectively. Each unit was similar to the singular ECD of the mammalian PRLR. The characteristic extracellular cysteines and the WSXWS motif of the cytokine receptor were conserved in both repeat units. The intracellular domain of dPRLR consisted of 368 amino acids at the C-terminus and contained 2 conserved regions-box 1 and box 2. The aforementioned characters of duck were all similar to chicken and mammalians, which implied that the dPRLR had same mechanism with other species. Sequence similarity analysis shows that the dPRLR shares ~45 to 97% amino identity and ~30 to 96% nucleic acid identity as compared with other species. Overall, the greatest sequence identity was found with goose PRLR. In a phylogenetic analysis, the duck PRLR was found to cluster with the PRLR of goose, turkey, chicken, and pigeon. Semiquantitative reverse transcription-PCR indicated that dPRLR mRNA was expressed in all 8 tissues. Expression in the kidney was greatest in varietals tissues. \u00a9 2009 Poultry Science Association Inc.",
        "keywords": [
            "Cloning",
            "Duck",
            "Prolactin receptor"
        ],
        "venue": "Poultry Science",
        "year": 2009,
        "id": "paS3viM7"
    },
    "jyUgFpzp": {
        "authors": [
            {
                "name": "Y. Ke",
                "org": "Institute of Genetics"
            },
            {
                "name": "B. Su",
                "org": "Institute of Genetics"
            },
            {
                "name": "H. Li",
                "org": "Institute of Genetics"
            },
            {
                "name": "L. Chen",
                "org": "Institute of Genetics"
            },
            {
                "name": "C. Qi",
                "org": "Institute of Genetics"
            },
            {
                "name": "X. Guo",
                "org": "Institute of Genetics"
            },
            {
                "name": "W. Huang",
                "org": "Institute of Genetics"
            },
            {
                "name": "J. Jin",
                "org": "Institute of Genetics"
            },
            {
                "name": "D. Lu",
                "org": "Institute of Genetics"
            },
            {
                "name": "L. Jin",
                "org": "Institute of Genetics"
            }
        ],
        "title": "Y-chromosome evidence for no independent origin of modern human in China",
        "abstract": "East Asia is one of the few regions in the world where a large number of human fossils have been unearthed. The continuity of hominid fossils in East Asia, particularly in China has been presented as strong evidence supporting an independent origin of modern humans in this area. To search for such evidence of a possible independent origin of modern humans in China, a total of 9988 male individuals were sampled across China. Three Y-chromosome biallelic markers (M89, M130 and YAP), which were located at the non-recombinant region of Y-chromosome, were typed among the samples. Our result showed that all the individuals carry a mutation at one of the three loci. The three mutations (M89T, M130T, YAP",
        "keywords": [
            "Chinese",
            "Haplotype",
            "Modern human origin",
            "SNPs",
            "Y-chromosome"
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2001,
        "id": "jyUgFpzp"
    },
    "I6QRBuEQ": {
        "authors": [
            {
                "name": "P.P. He",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "X.J. Zhang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Q. Yang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "M. Li",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Y.H. Liang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "S. Yang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "K.L. Yan",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Y. Cui",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Y.Y. Shen",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "H.Y. Wang",
                "org": "Institute of Dermatology"
            },
            {
                "name": "L.D. Sun",
                "org": "Institute of Dermatology"
            },
            {
                "name": "W.H. Du",
                "org": "Institute of Dermatology"
            },
            {
                "name": "Y.J. Shen",
                "org": "Institute of Dermatology"
            },
            {
                "name": "S.J. Xu",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "W. Huang",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            }
        ],
        "title": "Refinement of a locus for Marie Unna hereditary hypotrichosis to a 1.1-cM interval at 8p21.3",
        "keywords": [
            "Haplotype",
            "Linkage analysis",
            "Marie Unna hereditary hypotrichosis",
            "Refined mapping"
        ],
        "venue": "British Journal of Dermatology",
        "year": 2004,
        "id": "I6QRBuEQ"
    },
    "Lb0Tc3So": {
        "authors": [
            {
                "name": "P.P. He",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "C.D. He",
                "org": "Department of Dermatology"
            },
            {
                "name": "Y. Cui",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "S. Yang",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "H.H. Xu",
                "org": "Department of Dermatology"
            },
            {
                "name": "M. Li",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "W.T. Yuan",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "M. Gao",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "Y.H. Liang",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "C.R. Li",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "S.J. Xu",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "J.J. Chen",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "H.D. Chen",
                "org": "Department of Dermatology"
            },
            {
                "name": "W. Huang",
                "org": "Chinese Natl. Hum. Genome Ctr. S."
            },
            {
                "name": "X.J. Zhang",
                "org": "Key Laboratory of Genome Research"
            }
        ],
        "title": "Refined localization of dyschromatosis symmetrica hereditaria gene to a 9\u00b74-cM region at 1q21-22 and a literature review of 136 cases reported in China",
        "abstract": "Background: Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis characterized by hyperpigmented and hypopigmented macules on the extremities, which has recently been mapped to an 11.6-cM interval on chromosome 1q11-21. So far, most cases of DSH have been reported in Japan and dermatologists around the world might think this disorder mainly occurs in Japan. In fact, there are 17 DSH families including 136 cases reported in China since 1980, but most of them are described in Chinese. Objectives: To refine the previously mapped region that facilitates the identification of the DSH gene and to delineate the clinical and genetic features of Chinese DSH cases by a literature review of 136 cases reported in China. Methods: We performed genotyping and linkage analysis using polymorphic microsatellite markers at 1q11-22 in two Chinese DSH families, and reviewed all of the DSH cases reported in China since 1980. Results: A cumulative maximum two-point lod score of 3.68 was produced with marker D1S506 at a recombination frequency of \u03b8 = 0.00 in these two families. Haplotype analysis refined the DSH locus to a 9.4-cM interval flanked by D1S2343 and D1S2635. The genetic and clinical features of Chinese cases with DSH were summarized. In some Chinese cases, hyperpigmented and hypopigmented macules were scattered on the neck and chest, but among Japanese patients there were no similar skin lesions to be reported on these sites. Conclusions: This study confirms linkage of DSH to a previously mapped region and refines the DSH gene to a 9.4-cM interval at 1q21-22. Likewise, the literature review indicates that DSH is not an uncommon disorder in China and the differences in the distribution of skin lesions could be related to race and environment.",
        "keywords": [
            "Dyschromatosis symmetrica hereditaria",
            "Genotyping",
            "Haplotype analysis",
            "Hyperpigmented and hypopigmented macules",
            "Linkage analysis",
            "Literature review"
        ],
        "venue": "British Journal of Dermatology",
        "year": 2004,
        "id": "Lb0Tc3So"
    },
    "8LKzGykZ": {
        "authors": [
            {
                "name": "P.-G. Wang",
                "org": ""
            },
            {
                "name": "M. Gao",
                "org": ""
            },
            {
                "name": "G.-S. Lin",
                "org": ""
            },
            {
                "name": "S. Yang",
                "org": ""
            },
            {
                "name": "D. Lin",
                "org": ""
            },
            {
                "name": "Y.-H. Liang",
                "org": ""
            },
            {
                "name": "G.-L. Zhang",
                "org": ""
            },
            {
                "name": "Y.-G. Zhu",
                "org": ""
            },
            {
                "name": "Y. Cui",
                "org": ""
            },
            {
                "name": "K.-Y. Zhang",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            },
            {
                "name": "X.-J. Zhang",
                "org": ""
            }
        ],
        "title": "Genetic heterogeneity in acrokeratosis verruciformis of Hopf",
        "abstract": "Background. Acrokeratosis verruciformis of Hopf (AKV) is a rare genodermatosis characterized by multiple flat-topped, flesh-coloured papules on the dorsa of hands and feet, and punctuate keratoses on the palms and soles. A mutation in the ATP2A2 gene has been shown to be associated with AKV and with Darier's disease (DD). Objectives. To explore the molecular aetiology of AKV and DD. Methods. We investigated the clinical and histological information in two families and a sporadic case with AKV and one family and a sporadic case with DD in China. Mutation analysis of ATP2A2 was performed by PCR and direct sequencing, and genotyping and linkage analysis performed using six polymorphic microsatellite markers spanning the locus at 12q23-12q24 containing ATP2A2. Results. Mutational analysis showed no mutation in ATP2A2 among the AKV patients, but we found two novel mutations (p.C318F and p.M719fs) in the DD patients. The genotyping and linkage analysis results revealed no linkage evidence of the locus at 12q23-12q24 in a large AKV family. Conclusions. Our findings provide evidence for the genetic heterogeneity of AKV and demonstrate that mutations in genes other than ATP2A2 are responsible for AKV in a proportion of the Chinese population. \u00a9 2006 Blackwell Publishing Ltd.",
        "keywords": [
            ""
        ],
        "venue": "Clinical and Experimental Dermatology",
        "year": 2006,
        "id": "8LKzGykZ"
    },
    "vr2BaEVm": {
        "authors": [
            {
                "name": "M. Xie",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "S.X. Wang",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition"
            }
        ],
        "title": "Interaction between dietary calcium and non-phytate phosphorus on growth performance and bone ash in early White Pekin ducklings",
        "abstract": "A 4 \u00d7 5 factorial experiment containing four non-phytate phosphorus (NPP) levels (2.0, 3.0, 4.0, 5.0 g/kg) and five calcium (Ca) levels (4.0, 6.0, 8.0, 10.0, 12.0 g/kg) was conducted to evaluate the interaction between dietary Ca and NPP on growth performance and bone ash in White Pekin ducklings from hatch to 14 days of age. A total of 1280 one-day-old male White Pekin ducklings were assigned to twenty experimental treatments, each containing 4 replicate pens with 16 birds per pen, and these birds were raised with feed and water provided ad libitum. At 14 days of age, weight gain, feed intake, feed/gain and tibia ash of each treatment were measured. In the current study, the interaction between dietary Ca and NPP significantly influenced weight gain, feed intake, feed/gain, and tibia ash but the overall effects of these two minerals on these parameters except tibia ash were not significant. The weight gain, feed intake and tibia ash decreased (P<0.01) as dietary Ca increased from 4.0 to 12.0 g/kg at the lowest NPP level (2.0 g/kg) but these adverse effects could be alleviated or reversed at other dietary NPP from 3.0 to 5.0 g/kg. Considering the significant interaction between dietary Ca and NPP, the quadratic response surface regression analysis was used to predict the Ca and NPP requirements of ducklings. According to this regression analysis, the predicted requirements of Ca and NPP for maximum weight gain and minimum feed/gain were 8.06 and 4.03 g/kg, 7.96 and 3.79 g/kg, respectively. \u00a9 2009 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Calcium",
            "Duckling",
            "Non-phytate phosphorus",
            "Requirement"
        ],
        "venue": "Animal Feed Science and Technology",
        "year": 2009,
        "id": "vr2BaEVm"
    },
    "eFyzCaIH": {
        "authors": [
            {
                "name": "Y.N. Min",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "Y.P. Gao",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "F.Z. Liu",
                "org": "College of Animal Science and Technology"
            }
        ],
        "title": "Effect of dietary crude protein and energy on gosling growth performance and carcass trait",
        "abstract": "The study was undertaken to assess dietary CP and ME concentrations for optimum growth performance and carcass characteristics of goslings. In a 5 x 3 factorial arrangement, 360 one-day-old commercial generation Huoyan goslings were randomly assigned to experimental diets with 10.87, 11.37, 11.87, 12.37, and 12.87 MJ of ME/kg of diet; each contained 15.0, 17.5, and 20.0% CP, respectively, from 0 to 4 wk of age (WOA). Each dietary treatment was replicated 6 times. Body weight and feed consumption were measured, and carcass characteristics were evaluated at 4 WOA. The result showed that birds on a diet with 11.87, 12.37, and 12.87 MJ of ME/kg at 0 to 4 WOA exhibited greater BW gain than those on a diet with 10.87 and 11.37 MJ of ME/kg (P < 0.01), though BW gain was not different among 11.87, 12.37, and 12.87 MJ of ME/kg of diet. Mean BW gain of birds fed 17.5 and 20.0% CP diets was not different (P > 0.05), but they were higher than those on 15.0% dietary CP concentration (P < 0.001). Feed intake was not influenced by dietary ME levels (P > 0.05). Feed intake of birds fed 17.5 and 20.0% CP diets was higher than those of birds on 15.0% CP diets (P < 0.01). Feed conversion ratios of birds fed on 11.87, 12.37, and 12.87 MJ of ME/kg of diet were better than those fed on 10.87 and 11.37 MJ of ME/kg (P < 0.001). Feed conversion ratios of birds fed on 17.5 and 20.0% CP diets were better than those fed on 15.0% CP diets. Moreover, there were no significant interactions between CP and ME on growth performance. There was a direct relationship between dietary ME levels and eviscerated carcass percentage, abdominal fat percentage, and liver relative weight (P < 0.01). Breast and leg meat percentage were influenced by dietary CP concentrations significantly (P < 0.001). Thus, diets with 11.87 MJ of ME/kg and 17.5 to 20.0% CP were used more efficiently from 0 to 4 WOA by Huoyan goslings. \u00a92007 Poultry Science Association Inc.",
        "keywords": [
            "Carcass trait",
            "Crude protein",
            "Gosling",
            "Growth performance",
            "Metabolizable energy"
        ],
        "venue": "Poultry Science",
        "year": 2007,
        "id": "eFyzCaIH"
    },
    "VjbedhfZ": {
        "authors": [
            {
                "name": "T.H. Luo",
                "org": ""
            },
            {
                "name": "Y. Zhao",
                "org": ""
            },
            {
                "name": "G. Li",
                "org": ""
            },
            {
                "name": "W.T. Yuan",
                "org": ""
            },
            {
                "name": "J.J. Zhao",
                "org": ""
            },
            {
                "name": "J.L. Chen",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            },
            {
                "name": "M. Luo",
                "org": ""
            }
        ],
        "title": "A genome-wide search for type II diabetes susceptibility genes in Chinese Hans",
        "keywords": [
            "Candidate gene",
            "Genome-wide scan",
            "Linkage analysis",
            "Susceptibility",
            "Type II diabetes"
        ],
        "venue": "Diabetologia",
        "year": 2001,
        "id": "VjbedhfZ"
    },
    "TE4o59GY": {
        "authors": [
            {
                "name": "W. Liu",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "H. Wang",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "S. Zhao",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "W. Zhao",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "S. Bai",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "Y. Zhao",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "S. Xu",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "C. Wu",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "W. Huang",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "Z. Chen",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "G. Feng",
                "org": "Shanghai Inst. for Biological Sci."
            },
            {
                "name": "L. He",
                "org": "Shanghai Inst. for Biological Sci."
            }
        ],
        "title": "The novel gene locus for agenesis of permanent teeth (He-Zhao deficiency) maps to chromosome 10q11.2",
        "abstract": "He-Zhao deficiency has been recently characterized with a distinct form of agenesis of permanent teeth that is different from other previously reported disorders of tooth agenesis. This inherited abnormality suggests that some gene(s) associated with the development of permanent teeth may mutate. In this study, we map the gene locus to chromosome 10q11.2. The DNA pooling method combined with two-point and multi-point linkage analysis has been successfully applied. The maximum LOD (Zmax) scores for two-point and multi-point analyses are 13.29 (on marker D10S196) at recombination fraction (\u03b8) = 0 and 18.09 (between markers D10S1772 and D10S1766), respectively. Haplotype analysis confined the locus within an interval of 5.5 cM flanked by markers D10S604 and D10S568. This study has demonstrated a novel gene locus responsible for He-Zhao deficiency and provides a good likelihood for the discovery of one of the genes determining permanent tooth formation and development.",
        "keywords": [
            "10q11.2",
            "Agenesis of permanent teeth",
            "DNA pooling",
            "He-Zhao deficiency",
            "Linkage analysis"
        ],
        "venue": "Journal of Dental Research",
        "year": 2001,
        "id": "TE4o59GY"
    },
    "e2vQTlNo": {
        "authors": [
            {
                "name": "Y. Ke",
                "org": "Institute of Genetics"
            },
            {
                "name": "B. Su",
                "org": "Institute of Genetics"
            },
            {
                "name": "J. Xiao",
                "org": "Institute of Genetics"
            },
            {
                "name": "H. Chen",
                "org": "Institute of Genetics"
            },
            {
                "name": "W. Huang",
                "org": "Institute of Genetics"
            },
            {
                "name": "Z. Chen",
                "org": "Institute of Genetics"
            },
            {
                "name": "J. Chu",
                "org": "Institute of Genetics"
            },
            {
                "name": "J. Tan",
                "org": "Institute of Genetics"
            },
            {
                "name": "L. Jin",
                "org": "Institute of Genetics"
            },
            {
                "name": "D. Lu",
                "org": "Institute of Genetics"
            }
        ],
        "title": "Y-chromosome haplotype distribution in Han Chinese populations and modern human origin in East Asians",
        "abstract": "We investigated the distribution of Y-chromosome haplotype using 19 Y-SNPs in Han Chinese populations from 22 provinces of China. Our data indicate distinctive patterns of Y chromosome between southern and northern Han Chinese populations. The southern populations are much more polymorphic than northern populations. The latter has only a subset of the southern haplotypes. This result confirms the genetic difference observed between southern and northern ethnic populations in East Asia. It supports the hypothesis that the first settlement of modern humans of African origin occurred in the southern part of East Asia during the last Ice Age, and a northward migration led to the peopling of northern China.",
        "keywords": [
            "Chinese",
            "Emigration",
            "Modern human origin",
            "SNPs",
            "Y-chromosome haplotype"
        ],
        "venue": "Science in China, Series C: Life Sciences",
        "year": 2001,
        "id": "e2vQTlNo"
    },
    "Mhqo9epU": {
        "authors": [
            {
                "name": "H.P. Fan",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "M. Xie",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "W.W. Wang",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition"
            }
        ],
        "title": "Effects of dietary energy on growth performance and carcass quality of white growing Pekin ducks from two to six weeks of age",
        "abstract": "A dose-response experiment with 6 dietary energy levels (2,600, 2,700, 2,800, 2,900, 3,000, 3,100 kcal of AME/kg) was conducted to study the effects of dietary energy on growth performance and carcass quality of White Pekin ducks from 2 to 6 wk of age. Six hundred 14-d-old White Pekin ducks were randomly divided to 6 dietary treatments, each containing 5 replicate pens with 10 males and 10 females per pen, and these birds were raised until 6 wk of age. At 42 d of age, weight gain, feed intake, and feed:gain of ducks from each pen were measured, and 2 ducks (1 male and 1 female) selected randomly from each pen were slaughtered to evaluate the yields of abdominal fat, breast meat (including pectoralis major and pectoralis minor), and leg meat (including thigh and drumstick). As dietary energy increased from 2,600 to 3,100 kcal of AME/kg, the weight gain of ducks increased significantly, and the feed intake and feed:gain decreased significantly. According to the broken-line regression analysis, the AME requirements of White Pekin ducks from 2 to 6 wk of age for optimal weight gain and feed:gain were 3,008 and 3,030 kcal/kg, respectively, when dietary protein was 18%. On the other hand, high dietary energy did not affect breast and leg meat (P > 0.05), but abdominal fat increased (P < 0.05) when dietary AME was above 2,700 kcal/kg. \u00a92008 Poultry Science Association Inc.",
        "keywords": [
            "Duck",
            "Energy",
            "Requirement"
        ],
        "venue": "Poultry Science",
        "year": 2008,
        "id": "Mhqo9epU"
    },
    "4y0QMouC": {
        "authors": [
            {
                "name": "L.D. Sun",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "S. Yang",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "J.J. Liu",
                "org": "Human Genetics Laboratory"
            },
            {
                "name": "Y.Q. Ren",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "X. Fan",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "S.X. Xu",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "L. Zhou",
                "org": "Department of Anatomy"
            },
            {
                "name": "C.J. Yang",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "F.L. Xiao",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "M. Gao",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "Y. Cui",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "W.H. Du",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            },
            {
                "name": "W. Huang",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "X.J. Zhang",
                "org": "Key Laboratory of Gene Resource Utilization for Severe Diseases"
            }
        ],
        "title": "Follow-up analysis of 180 Chinese Han families: Identification of a novel locus for psoriasis at 2p22.3-11.2",
        "abstract": "Background: Psoriasis is a common inflammatory and hyperproliferative skin disease. The pathogenesis of psoriasis remains obscure. Family and twin studies have suggested a strong genetic susceptibility to psoriasis. Eight linkage loci (PSORS1-7, PSORS9) were identified and accepted by the OMIM and an additional 16 susceptibility loci have been suggested so far. Objectives: To investigate further three suggested psoriasis susceptibility loci at 2p22.3-11.2, 13q21-32 and 17q22-25.3 in a Chinese population. Using an expanded sample of 180 Chinese families with psoriasis and improved marker coverage, we verified whether they were Chinese Han psoriasis susceptibility loci. Methods: In total, 180 Chinese Han families with psoriasis vulgaris (including the 61 families used in the original genome-wide scan and 119 new families) were recruited from the Dermatology Department at the First Hospital Affiliated to Anhui Medical University. Two-point and multipoint parametric and nonparametric linkage (NPL) analyses were performed at 2p, 13q and 17q in the total 180 families as well as the 61 original and 119 new families separately. Results: At the region 2p, a maximum multipoint NPL score of 4.11 was identified at locus D2S337 (P = 0.000003), and a maximum multipoint heterogeneity LOD (HLOD) score of 4.93 (\u03b1 = 54%) was identified at the same locus in the analysis of the 180 families. However, the analysis of the 180 families did not identify any significant linkage evidence at the region 13q21-32 [a maximum multipoint HLOD score of 0.10 (\u03b1 = 7%) and NPL score of 0.95 (P = 0.14)] or the region 17q22-25.3 [a maximum multipoint HLOD score of 0.08 (\u03b1 = 6%) and NPL value of 0.94 (P = 0.14)]. For these two regions, the LOD scores from the 180 families as well as the 119 new families were much smaller than the ones obtained from the original 61 families. Conclusions: Our study indicates that 2p22.3-11.2 is a novel psoriasis susceptibility locus in the Chinese Han population and confirms that psoriasis is a genetically heterogeneous disease. \u00a9 2008 The Authors.",
        "keywords": [
            "13q21-32",
            "17q22-25.3",
            "2p22.3-11.2",
            "Linkage analysis",
            "Psoriasis vulgaris"
        ],
        "venue": "British Journal of Dermatology",
        "year": 2008,
        "id": "4y0QMouC"
    },
    "lNFTnW7j": {
        "authors": [
            {
                "name": "K.L. Yan",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "P.P. He",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "S. Yang",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "M. Li",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "Q. Yang",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "Y.Q. Ren",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "Y. Cui",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "M. Gao",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "F.L. Xiao",
                "org": "Key Laboratory of Genome Research"
            },
            {
                "name": "W. Huang",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "X.J. Zhang",
                "org": "Institute of Dermatology"
            }
        ],
        "title": "Marie Unna hereditary hypotrichosis: Report of a Chinese family and evidence for genetic heterogeneity",
        "abstract": "Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal dominant disorder with progressive hair loss starting in early childhood and aggravating at puberty. Several studies have mapped the MUHH gene to chromosome 8p21. Here we report a Chinese MUHH family with variable phenotypes. All affected individuals have anomalies affecting both hair density and hair shafts. Major clinical characteristics, disease history and histological examination support the diagnosis of MUHH, but the features of scarring in this kindred are modest and none of the patients have vertex hair loss, which is in contrast with typical MUHH. We now report genotyping and linkage analysis using 11 polymorphic microsatellite markers spanning the MUHH locus at 8p. Two-point linkage analysis using these markers revealed significant exclusion of this locus (log of the odds scores < - 2) at \u03b8 = O indicating that there is a range of clinical presentations in MUHH, and that more than one genetic locus is responsible for the disorder.",
        "keywords": [
            ""
        ],
        "venue": "Clinical and Experimental Dermatology",
        "year": 2004,
        "id": "lNFTnW7j"
    },
    "snRq3rVI": {
        "authors": [
            {
                "name": "A. Sun",
                "org": "Shanghai Institute of Cardiovascular Diseases"
            },
            {
                "name": "L. Xu",
                "org": "Department of Cardiology"
            },
            {
                "name": "S. Wang",
                "org": "Department of Cardiology"
            },
            {
                "name": "K. Wang",
                "org": "Department of Cardiology"
            },
            {
                "name": "W. Huang",
                "org": "Chinese National Human Genome Center at Shanghai"
            },
            {
                "name": "Y. Wang",
                "org": "Chinese National Human Genome Center at Shanghai"
            },
            {
                "name": "Y. Zou",
                "org": "Department of Cardiology"
            },
            {
                "name": "J. Ge",
                "org": "Department of Cardiology"
            }
        ],
        "title": "SCN5A R1193Q polymorphism associated with progressive cardiac conduction defects and long QT syndrome in a Chinese family",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Journal of Medical Genetics",
        "year": 2008,
        "id": "snRq3rVI"
    },
    "PsfiMTYx": {
        "authors": [
            {
                "name": "J. You",
                "org": "Department of Immunotherapy"
            },
            {
                "name": "M. Song",
                "org": "Department of Immunotherapy"
            },
            {
                "name": "H. Huang",
                "org": "Department of Immunotherapy"
            },
            {
                "name": "E. Yu",
                "org": "Department of Immunotherapy"
            },
            {
                "name": "W. Huang",
                "org": "Department of Immunotherapy"
            },
            {
                "name": "Y. Lin",
                "org": "Department of Immunotherapy"
            }
        ],
        "title": "Effect of Jianpi Liqi priscription combined with rIL-2 on immune supression caused by chemotherapy",
        "abstract": "Purpose: To observe the effect of traditional Chinese prescription of Jianpi Liqi combined with rIL-2 on immune suppression caused by chemotherapy. Methods: H",
        "keywords": [
            "Chemotherapy",
            "Immune supression",
            "Jianpi liqi herbs",
            "rIL-2"
        ],
        "venue": "Journal of Shanghai Medical University",
        "year": 1999,
        "id": "PsfiMTYx"
    },
    "XsXlpIVI": {
        "authors": [
            {
                "name": "J. Shi",
                "org": "Chinese Human Genome Center"
            },
            {
                "name": "S. Yang",
                "org": "Chinese Human Genome Center"
            },
            {
                "name": "Z. Jiang",
                "org": "Chinese Human Genome Center"
            },
            {
                "name": "H. Jiang",
                "org": "Chinese Human Genome Center"
            },
            {
                "name": "T. Chen",
                "org": "Chinese Human Genome Center"
            },
            {
                "name": "Z. Chen",
                "org": "Chinese Human Genome Center"
            },
            {
                "name": "W. Huang",
                "org": "Chinese Human Genome Center"
            }
        ],
        "title": "Comparison of denaturing high performance liquid chromatography with direct sequencing in the detection of single nucleotide polymorphism",
        "abstract": "Objective Investigate the sensitivity and accuracy of the denaturing high performance liquid chromatography (DHPLC) technique for the detection of single nucleotide polymorphism (SNP). Methods Forty-one samples were detected by both DHPLC and direct sequencing. Results The comparison demonstrated that DHPLC detected all heterozygous sequences found by direct sequencing. No false-positive signals were seen in the cases of homozygous sequences. Furthermore, no false-negative results were ever obtained with heterozygous mutations or polymorphisms, or both. Conclusion DHPLC is a potent method for SNP identification especially SNP typing in large scale screening.",
        "keywords": [
            "Denaturing high performance liquid chromatography",
            "DNA sequencing",
            "Single nucleotide polymorphism"
        ],
        "venue": "Chinese Journal of Medical Genetics",
        "year": 2001,
        "id": "XsXlpIVI"
    },
    "GzqPP4Cq": {
        "authors": [
            {
                "name": "J.Y. Zhao",
                "org": ""
            },
            {
                "name": "M.M. Xiong",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            },
            {
                "name": "H. Wang",
                "org": ""
            },
            {
                "name": "J. Zuo",
                "org": ""
            },
            {
                "name": "G.D. Wu",
                "org": ""
            },
            {
                "name": "Z. Chen",
                "org": ""
            },
            {
                "name": "B.Q. Qiang",
                "org": ""
            },
            {
                "name": "M.L. Zhang",
                "org": ""
            },
            {
                "name": "J.L. Chen",
                "org": ""
            },
            {
                "name": "W. Ding",
                "org": ""
            },
            {
                "name": "W.T. Yuan",
                "org": ""
            },
            {
                "name": "H.Y. Xu",
                "org": ""
            },
            {
                "name": "L. Jin",
                "org": ""
            },
            {
                "name": "Y.X. Li",
                "org": ""
            },
            {
                "name": "Q. Sun",
                "org": ""
            },
            {
                "name": "Q.Y. Liu",
                "org": ""
            },
            {
                "name": "E. Boerwinkle",
                "org": ""
            },
            {
                "name": "F.D. Fang",
                "org": ""
            }
        ],
        "title": "An autosomal genomic scan for loci linked to type 2 diabetes in northern Han Chinese",
        "abstract": "We report the results of a genome-wide scan conducted in 219 individuals from 34 large multiplex nuclear pedigrees from the northern Han Chinese population at an average resolution of about 10 cM. Nonparametric two-point and multipoint linkage analyses were performed to detect evidence of linkage with type 2 diabetes in this study. On chromosome 1 four regions showed evidence of linkage with type 2 diabetes in northern Han Chinese. Of these regions a marker D1S193 (73 cM) showed evidence of linkage (two-point nonparametric linkage 2.409), and another region (around 190 cM) was a replication of several other studies performed in different ethnic populations. Evidences of linkage have been confirmed by typing additional markers (average distance 1-5 cM) flanking these two positive regions on chromosome 1. We also found indication of linkage with type 2 diabetes on chromosomes 2, 10, 12, 18, 20, and 22 by two-point linkage analyses. \u00a9 Springer-Verlag 2004.",
        "keywords": [
            "Linkage analysis",
            "Type 2 diabetes",
            "Whole-genome scan"
        ],
        "venue": "Journal of Molecular Medicine",
        "year": 2005,
        "id": "GzqPP4Cq"
    },
    "zZUDIYqa": {
        "authors": [
            {
                "name": "W. Huang",
                "org": "National Human Genome Center at Beijing"
            },
            {
                "name": "W. Yang",
                "org": "Division of Population Genetics and Prevention"
            },
            {
                "name": "Y. Wang",
                "org": "Division of Population Genetics and Prevention"
            },
            {
                "name": "Q. Zhao",
                "org": "Division of Population Genetics and Prevention"
            },
            {
                "name": "D. Gu",
                "org": "Division of Population Genetics and Prevention"
            },
            {
                "name": "R. Chen",
                "org": "Bioinformatics Laboratory"
            }
        ],
        "title": "Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Journal of Human Hypertension",
        "year": 2006,
        "id": "zZUDIYqa"
    },
    "mmBv3VDW": {
        "authors": [
            {
                "name": "M. Xie",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "H.P. Fan",
                "org": "State Key Laboratory of Animal Nutrition"
            }
        ],
        "title": "Effect of excess methionine and methionine hydroxy analogue on growth performance and plasma homocysteine of growing Pekin ducks",
        "abstract": "One experiment was conducted to study the effect of excess DL-methionine (DLM) and DL-2-hydroxy-4-methylthiobutanoic acid free acid (DL-HMB-FA) on duck growth. One-day-old male white Pekin ducklings were fed common starter diets from hatch to 21 d of age and then fed the experimental diets from 21 to 42 d of age. Three hundred twenty 21-d-old birds were allotted to 40 raised wire-floor pens with 8 birds per pen according to similar pen weight. There were 5 dietary treatments that included a methionine-adequate control diet and control diets supplemented with 2 levels of dry DLM (1 or 2%) or 2 equimolar levels of liquid DL-HMB-FA (1.13 or 2.26%). Each dietary treatment was replicated 8 times. At 42 d of age, weight gain, feed intake, and gain/feed were measured and plasma was collected to analyze homocysteine. Compared with ducks fed control diets, excess DLM or DL-HMB-FA supplementation reduced weight gain and feed intake of birds significantly. However, on the equimolar basis, at 1 or 2% supplemental methionine activity, DL-HMB-FA was less growth-depressing than DLM. According to the growth response to excess methionine, the tolerable upper limit of dietary methionine for growing ducks may be less than 1.38% when the methionine level of the control diet (0.38%) was considered. On the other hand, plasma homocysteine was elevated markedly when 2% DLM or 2.26% DL-HMB-FA was added to control diets, but plasma homocysteine of ducks fed 2.26% DL-HMB-FA supplemented diets was lower significantly than birds fed equimolar DLM-supplemented diets, which indicated the toxicity of excess methionine sources and less toxicity of DL-HMB-FA relative to DLM. \u00a92007 Poultry Science Association Inc.",
        "keywords": [
            "Duck",
            "Methionine",
            "Methionine hydroxy analogue",
            "Toxicity"
        ],
        "venue": "Poultry Science",
        "year": 2007,
        "id": "mmBv3VDW"
    },
    "9aozYkOm": {
        "authors": [
            {
                "name": "M. Gao",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "S. Yang",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "M. Li",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "K.L. Yan",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "Y.X. Jiang",
                "org": "Department of Dermatology"
            },
            {
                "name": "Y. Cui",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "F.L. Xiao",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "Y.J. Shen",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "J.J. Chen",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "J.B. Liu",
                "org": "Key Laboratory of Genome Research at Anhui"
            },
            {
                "name": "S.J. Xu",
                "org": "Chinese National Human Genome Center at Shanghai"
            },
            {
                "name": "W. Huang",
                "org": "Chinese National Human Genome Center at Shanghai"
            },
            {
                "name": "Xue-Jun Zhang",
                "org": "Key Laboratory of Genome Research at Anhui"
            }
        ],
        "title": "Refined localization of a punctate palmoplantar keratoderma gene to a 5-06-cM region at 15q22.2-15q22.31",
        "abstract": "Background: Punctate palmoplantar keratoderma (PPK) is a rare autosomal dominant cutaneous disorder characterized by numerous hyperkeratotic papules distributed on the palms and soles. Two loci for punctate PPK were recently found to be located on 8q24.13-8q24.21 and 15q22-15q24. However, no genes for this disease have been identified to date. Objectives: To refine the previously mapped regions and to identify the disease gene locus in a four-generation Chinese family with punctate PPK. Methods: Genetic linkage analysis was carried out in this family using microsatellite markers on chromosomes 8q and 15q. Two-point linkage analysis was performed using Linkage programs version 5.10 and the haplotype was constructed using Cyrillic version 2.02 software. Results: We failed to confirm our previous locus at 8q24.13-8q24.21, but significant evidence for linkage was observed in the region of 15q with a maximum two-point LOD score of 5.38 at D15S153 (\u03b8 = 0.00). Haplotype analysis localized the punctate PPK locus within the region defined by D15S651 and D15S988. This region overlaps by 5.06 cM with the previously reported punctate PPK region. Conclusions: This study refines a disease gene causing punctate PPK to a 5-06-cM interval at 15q22.2-15q22.31. \u00a9 2005 British Association of Dermatologists.",
        "keywords": [
            "Gene mapping",
            "Linkage analysis",
            "Punctate palmoplantar keratoderma"
        ],
        "venue": "British Journal of Dermatology",
        "year": 2005,
        "id": "9aozYkOm"
    },
    "1BSzjau3": {
        "authors": [
            {
                "name": "J.Y. Chu",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            },
            {
                "name": "S.Q. Kuang",
                "org": ""
            },
            {
                "name": "J.M. Wang",
                "org": ""
            },
            {
                "name": "J.J. Xu",
                "org": ""
            },
            {
                "name": "Z.T. Chu",
                "org": ""
            },
            {
                "name": "Z.Q. Yang",
                "org": ""
            },
            {
                "name": "K.Q. Lin",
                "org": ""
            },
            {
                "name": "P. Li",
                "org": ""
            },
            {
                "name": "M. Wu",
                "org": ""
            },
            {
                "name": "Z.C. Geng",
                "org": ""
            },
            {
                "name": "C.C. Tan",
                "org": ""
            },
            {
                "name": "R.F. Du",
                "org": ""
            },
            {
                "name": "L. Jin",
                "org": ""
            }
        ],
        "title": "Genetic relationship of populations in China",
        "abstract": "Despite the fact that the continuity of morphology of fossil specimens of modern humans found in China has repeatedly challenged the Out-of-Africa hypothesis, Chinese populations are underrepresented in genetic studies. Genetic profiles of 28 populations sampled in China supported the distinction between southern and northern populations, while the latter are biphyletic. Linguistic boundaries are often transgressed across language families studied, reflecting substantial gene flow between populations. Nevertheless, genetic evidence does not support an independent origin of Homo sapiens in China. The phylogeny also suggested that it is more likely that ancestors of the populations currently residing in East Asia entered from Southeast Asia.",
        "keywords": [
            ""
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 1998,
        "id": "1BSzjau3"
    },
    "5tdsFKBk": {
        "authors": [
            {
                "name": "Z. Jiang",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "J. Shi",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "S. Yang",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "C. Zhang",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "H. Jiang",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "Z. Chen",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "L. Jin",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "D. Lu",
                "org": "Chinese National Human Genome Center"
            },
            {
                "name": "W. Huang",
                "org": "Chinese National Human Genome Center"
            }
        ],
        "title": "A simple and rapid new method for SNP typing by single-tube bi-directional allele specific amplification",
        "abstract": "Objective: To establish a new method for single nucleotide polymorphism (SNP) typing based on allele specific PCR: single-tube bi-directional amplification (SB-ASA), and study the influence on specific extension by introducing a mismatch at the third 3\u2032-terminal base of allele specific primers. Methods: Two allele specific primers, with a mismatch introduced at the third 3\u2032-terminal base, were both included in PCR system; they extended in opposite directions and amplified two allele specific fragments different in size. The genotype was determined by observing the length of amplified fragments after agarose electrophoresis. The proper ranges of annealing temperature (Ta) under which primers can specifically extend were achieved by observing the amplification status at different temperatures. Results: SB-ASA was successfully used to type 36 samples for four different kinds of SNPs. Typing results were completely consistent with those by directional sequencing. Proper Ta ranges of two primers were expanded respectively from 64\u00b0C-69\u00b0C to 46\u00b0C-66\u00b0C and from 60\u00b0C-62\u00b0C to 56\u00b0C-61\u00b0C by introducing a mismatch at the third 3\u2032-terminal base. Conclusion: SB-ASA is a simple, rapid and efficient new method for SNP typing. During allele specific PCR reaction, specific primers with a mismatch at the third 3\u2032-terminal base have more power to identify two alleles.",
        "keywords": [
            "Single nucleotide polymorphism",
            "Single nucleotide polymorphism typing",
            "Single-tube bi-directional allele specific amplification"
        ],
        "venue": "Chinese Journal of Medical Genetics",
        "year": 2001,
        "id": "5tdsFKBk"
    },
    "lrpi2kjX": {
        "authors": [
            {
                "name": "S. Guo",
                "org": ""
            },
            {
                "name": "N.-H. Chen",
                "org": ""
            },
            {
                "name": "R. Guan",
                "org": ""
            },
            {
                "name": "J. Feng",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            }
        ],
        "title": "Effects of anti-bursin monoclonal antibody on immunosuppression in the duck (Cherry Valley duck)",
        "abstract": "To study the immunologic function of bursin, we analyzed the effects of anti-bursin monoclonal antibody (mAb) on the immunosuppression in ducks (Cherry Valley duck) by injecting various doses of the anti-bursin mAb into 13-d duck embryos. After hatch, cell-mediated immune activity and humoral responses were studied using lymphocyte proliferation test, tube agglutination test, and indirect enzyme-linked immunosorbent assay to detect anti-Escherichia coli antibodies and antibodies to Riemerella anatipestifer, respectively. Simultaneously, relative weights (BW-adjusted) of bursa of Fabricius (BF), spleen, and thymus were determined. Additionally, the morphology of BF, spleen, and thymus was examined at various ages using conventional histology. Follicle morphology of BF was analyzed by image analysis. The results indicated that anti-bursin mAb markedly decreased duck lymphocyte proliferation, the antibody-producing ability to bacteria, as well as the relative BF weight. Moreover, the anti-bursin mAb hindered the development of BF follicles. \u00a92006 Poultry Science Association, Inc.",
        "keywords": [
            "Anti-bursin monoclonal antibody",
            "Bursin",
            "Cherry Valley duck",
            "Immune function",
            "Immunosuppression"
        ],
        "venue": "Poultry Science",
        "year": 2006,
        "id": "lrpi2kjX"
    },
    "6O2jwQMb": {
        "authors": [
            {
                "name": "X. Ding",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            },
            {
                "name": "J. Zhang",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "B. Li",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            },
            {
                "name": "Z. Wang",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            },
            {
                "name": "W. Huang",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            },
            {
                "name": "T. Zhou",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            },
            {
                "name": "Y. Wei",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            },
            {
                "name": "H. Li",
                "org": "Shandong's Key Laboratory of Radition Oncology"
            }
        ],
        "title": "A meta-analysis of lymph node metastasis rate for patients with thoracic oesophageal cancer and its implication in delineation of clinical target volume for radiation therapy",
        "abstract": "Objectives: The objective of this study was to pool the lymph node metastasis rate (LNMR) in patients with thoracic oesophageal cancer (TOC) and to determine which node level should be included when undergoing radiation therapy. Methods: Qualified studies were identified on Medline, Embase, CBM and the Cochrane Library through to the end of April 2011. Pooled estimates of LNMR were obtained through a random-effect model. Possible effect modifiers which might lead to the statistical heterogeneity were identified through meta-regression, and further subgroup analyses of factors influencing LNMR were performed. Results: 45 observational studies with a total of 18415 patients were included in the meta-analysis. The pooled estimates of LNMR in upper, middle and lower TOC were 30.7%, 16.8% and 11.0% cervical, 42.0%, 21.1% and 10.5% upper mediastinal, 12.9%, 28.1% and 19.6% middle mediastinal, 2.6%, 7.8% and 23.0% lower mediastinal, and 9%, 21.4% and 39.9% abdominal, respectively. Lymph node metastasis most frequently happened to paratracheal, paraoesophageal, perigastric 106recR and station 7. The most obvious difference ($15%) of LNMR between two-field and three-field lymphatic dissection occurred in cervical, paratracheal, 106recR and 108. Conclusions: Through the meta-analysis, more useful information was obtained about clinical target volume (CTV) delineation of TOC patients treated with radiotherapy. However, our study is predominantly a description of squamous carcinoma and the results may not be valid for adenocarcinoma. \u00a9 2012 The British Institute of Radiology.",
        "keywords": [
            ""
        ],
        "venue": "British Journal of Radiology",
        "year": 2012,
        "id": "6O2jwQMb"
    },
    "u0su34HJ": {
        "authors": [
            {
                "name": "Y. Lu",
                "org": "Oncology Center, Third People's Hospital of Jiujiang City"
            },
            {
                "name": "D. Xie",
                "org": "Division of Urology and Department of Surgery, Duke University Medical Center"
            },
            {
                "name": "W. Huang",
                "org": "Department of Radiation Oncology, Shandong Cancer Hospital and Institute"
            },
            {
                "name": "H. Gong",
                "org": "Department of Radiation Oncology, Shandong Cancer Hospital and Institute"
            },
            {
                "name": "J. Yu",
                "org": "Department of Radiation Oncology, Shandong Cancer Hospital and Institute"
            }
        ],
        "title": " 18F-FDG PET/CT in the evaluation of adrenal masses in lung cancer patients",
        "keywords": [
            "Adrenal masses",
            "Adrenal metastasis",
            "Lung cancer",
            "PET/CT"
        ],
        "venue": "Neoplasma",
        "year": 2010,
        "id": "u0su34HJ"
    },
    "pQVcSoKk": {
        "authors": [
            {
                "name": "X. He",
                "org": "Ruijin Hospital"
            },
            {
                "name": "D. Zhu",
                "org": "Ruijin Hospital"
            },
            {
                "name": "Z. Han",
                "org": "Ruijin Hospital"
            },
            {
                "name": "X. Liu",
                "org": "Ruijin Hospital"
            },
            {
                "name": "G. Wang",
                "org": "Ruijin Hospital"
            },
            {
                "name": "S. Chu",
                "org": "Ruijin Hospital"
            },
            {
                "name": "W. Zhang",
                "org": "Ruijin Hospital"
            },
            {
                "name": "H. Zhou",
                "org": "Ruijin Hospital"
            },
            {
                "name": "S. Mao",
                "org": "Ruijin Hospital"
            },
            {
                "name": "Q. Zhuang",
                "org": "Ruijin Hospital"
            },
            {
                "name": "Y. Zhao",
                "org": "Ruijin Hospital"
            },
            {
                "name": "W. Huang",
                "org": "Ruijin Hospital"
            }
        ],
        "title": "Use of microsatellites in zygosity diagnosis of twins",
        "abstract": "Objective: To diagnose zygosity of twins by microsatellite polymorphism. Methods: One hundred and eighty-four samples, including 69 pairs of twins with the same gender and 6 pairs of twins with different gender were recruited. Seventeen sib pairs were also collected for controls. Nine highly polymorphic microsatellite loci were amplified by polymerase chain reaction (PCR) using fluorescence-labeled primers and the products were sized by automated fragment analysis after electrophoresis and laser detection. Zygosity was diagnosed by comparing the concordance of the genotype of the 9 markers. Results. Sixty-three pairs of monozygotic (MZ) and 12 pairs of dizygotic (DZ) twins were assigned their zygosity by comparison of polymorphism of 9 microsatellite loci. Within each of the 63 monozygotic (MZ) pairs there was complete concordance. However, within each of the 12 dizygotic pairs and other 17 sib pairs, discordant loci were found. With five or six markers, the probability that any twin pair was MZ if all markers were concordant was 99% or 99.6%, respectively. With all the nine markers, the probability that any twin pair was MZ if all markers were concordant was 99.95%. Conclusion: The technology of gene scan and genotyping provides a rapid and reliable approach to zygosity detection.",
        "keywords": [
            "Genetics",
            "Microsatellite DNA",
            "Twin",
            "Zygosity diagnosis"
        ],
        "venue": "Chinese Journal of Medical Genetics",
        "year": 2001,
        "id": "pQVcSoKk"
    },
    "7INnNp88": {
        "authors": [
            {
                "name": "G. Li",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            },
            {
                "name": "D.N. Lerner",
                "org": ""
            },
            {
                "name": "X. Zhang",
                "org": ""
            }
        ],
        "title": "Enrichment of degrading microbes and bioremediation of petrochemical contaminants in polluted soil",
        "keywords": [
            "Biodegradation",
            "Hyphomicrobium Biological Activated Carbon enrichment system",
            "Natural attenuation",
            "Organic contaminant",
            "Polluted soil"
        ],
        "venue": "Water Research",
        "year": 2000,
        "id": "7INnNp88"
    },
    "kCIdOmhQ": {
        "authors": [
            {
                "name": "Y.Z. Zhang",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "J.X. Liu",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "H.Z. Shao",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "Z.W. Chi",
                "org": "Shanghai Institute of Biochemistry"
            },
            {
                "name": "H.L. Wang",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "S.J. Chen",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "Z. Chen",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "Z.Y. Wang",
                "org": "Shanghai Institute of Haematology"
            },
            {
                "name": "W. Huang",
                "org": "Shanghai Institute of Haematology"
            }
        ],
        "title": "Characterization of genetic defects of hemophilia A in mainland China",
        "abstract": "Southern blotting, PCR, DGGE and DNA sequencing were used to study gene mutations in 52 unrelated Chinese Hemophilia A patients. 18 out of 34 severe cases had intron 22 inversions, 13 had small gene lesions, of which five are novel. Copyright (C) 1999 Elsevier Science B.V.",
        "keywords": [
            "Hemophilia A",
            "Mutations",
            "Southern blotting"
        ],
        "venue": "Genetic Analysis - Biomolecular Engineering",
        "year": 1999,
        "id": "kCIdOmhQ"
    },
    "6KOykpu7": {
        "authors": [
            {
                "name": "R.-Q. Yu",
                "org": "Division of Hematology"
            },
            {
                "name": "W. Huang",
                "org": "Laboratory of Molecular Biology"
            },
            {
                "name": "S.-J. Chen",
                "org": "Laboratory of Molecular Biology"
            },
            {
                "name": "S.-D. Jiang",
                "org": "Division of Hematology"
            },
            {
                "name": "Z. Chen",
                "org": "Laboratory of Molecular Biology"
            }
        ],
        "title": "A case of acute eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression and response to all-trans retinoic acid",
        "abstract": "A typical case of eosinophilic granulocytic leukemia with PML-RAR alpha fusion gene expression is reported. The patient achieved complete remission after oral administration of all-trans retinoic acid without any exposure to cytotoxic agents. The facts strongly suggest that the genetic event occurred at the level of pluripotent stem cells.",
        "keywords": [
            "Eosinophilic",
            "Leukemia",
            "PML-RAR alpha",
            "Retinoic acid"
        ],
        "venue": "Leukemia",
        "year": 1997,
        "id": "6KOykpu7"
    },
    "RM0sxig7": {
        "authors": [
            {
                "name": "B.-S. Li",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "H.-Y. Gong",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "W. Huang",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "Y. Yi",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "Z.-C. Zhang",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "H.-S. Li",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "Z.-T. Wang",
                "org": "Sixth Department of Radiation Oncology"
            },
            {
                "name": "J.-M. Yu",
                "org": "Sixth Department of Radiation Oncology"
            }
        ],
        "title": "Phase I study of concurrent selective lymph node late course accelerated hyper-fractionated radiotherapy and pemetrexed, cisplatin for locally advanced esophageal squamous cell carcinoma",
        "abstract": "The optimized concurrent chemoradiotherapy has not been established for patients with advanced esophageal squamous cell carcinoma (SCC). The aim of the present study was to evaluate the safety and efficacy of concurrent chemotherapy and selective lymph node (SLN) late course accelerated hyperfractionated (LCAF) intensity modulated radiotherapy (IMRT) for the patients with thoracic SCC. Twelve patients with T3-4N0-1M0-1a thoracic esophageal SCC were included. The total dose of SLN LCAF IMRT was 59.6Gy/34 fractions in 5.4 weeks. The concurrent chemotherapy protocol was as following: cisplatin 10mg/m",
        "keywords": [
            "Chemoradiotherapy",
            "Cisplatin",
            "Esophageal squamous cell carcinoma",
            "Intensity modulated radiotherapy",
            "Pemetrexed"
        ],
        "venue": "Diseases of the Esophagus",
        "year": 2011,
        "id": "RM0sxig7"
    },
    "uVT326i9": {
        "authors": [
            {
                "name": "N. Zhao",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition Science"
            },
            {
                "name": "X.L. Liu",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "X.G. Yang",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition Science"
            }
        ],
        "title": "Six single nucleotide polymorphisms in adipocyte fatty acid-binding protein (A-FABP) gene in Beijing ducks",
        "abstract": "PCR-SSCP was applied to analyze the polymorphisms of A-FABP gene in 4 lines of Beijing ducks (n = 400). The results showed that six SNPs were found in intron 3. There were no polymorphisms found in exon 3 or exon 4. The discovered SNPs were deposited in GenBank (Acc. No.: EU306611 and EU306610). The frequencies of haplotypes A/B in the Z4, Z2, Cherry Valley, Z4 \u00d7 Z2 populations were 0.745/0.255, 0.764/0.236, 0.552/0.448, 0.672/0.328, respectively. The linkage disequilibrium was stated. The above described SNPs of A-FABP gene allow the incoming association analysis.",
        "keywords": [
            "A-FABP gene",
            "Beijing ducks",
            "PCR-SSCP",
            "SNPs"
        ],
        "venue": "Czech Journal of Animal Science",
        "year": 2010,
        "id": "uVT326i9"
    },
    "qhddWSir": {
        "authors": [
            {
                "name": "J. Zhao",
                "org": ""
            },
            {
                "name": "H. Wang",
                "org": ""
            },
            {
                "name": "M. Xiong",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            },
            {
                "name": "J. Zuo",
                "org": ""
            },
            {
                "name": "Z. Chen",
                "org": ""
            },
            {
                "name": "B. Qiang",
                "org": ""
            },
            {
                "name": "Q. Sun",
                "org": ""
            },
            {
                "name": "Y. Li",
                "org": ""
            },
            {
                "name": "Q. Liu",
                "org": ""
            },
            {
                "name": "W. Du",
                "org": ""
            },
            {
                "name": "J. Chen",
                "org": ""
            },
            {
                "name": "W. Ding",
                "org": ""
            },
            {
                "name": "W. Yuan",
                "org": ""
            },
            {
                "name": "Y. Zhao",
                "org": ""
            },
            {
                "name": "H. Xu",
                "org": ""
            },
            {
                "name": "L. Jin",
                "org": ""
            },
            {
                "name": "F. Fang",
                "org": ""
            }
        ],
        "title": "The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families",
        "keywords": [
            "Northern Han Chinese",
            "Susceptibility gene locus",
            "Type 2 diabetes"
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2000,
        "id": "qhddWSir"
    },
    "lnSvIs9K": {
        "authors": [
            {
                "name": "Y. Yang",
                "org": "Department of Endocrinology, Jiangxi Province Children's Hospital"
            },
            {
                "name": "H. Huang",
                "org": "Department of Endocrinology, Jiangxi Province Children's Hospital"
            },
            {
                "name": "W. Wang",
                "org": "Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine"
            },
            {
                "name": "L. Yang",
                "org": "Department of Endocrinology, Jiangxi Province Children's Hospital"
            },
            {
                "name": "L.L. Xie",
                "org": "Department of Endocrinology, Jiangxi Province Children's Hospital"
            },
            {
                "name": "W. Huang",
                "org": "Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai"
            }
        ],
        "title": "Association of insulin growth factor-1 receptor gene polymorphisms with genetic susceptibility to idiopathic short stature",
        "abstract": "The association between single nucleotide polymorphisms (SNPs) in the insulin-like growth factor-1 receptor (IGF-1R) gene and susceptibility to idiopathic short stature (ISS) was investigated. Seven hundred and twelve Chinese children clinically diagnosed with ISS and 575 normal individuals were recruited between 2008 and 2011, and their SNPs were genotyped. Preliminary screening revealed that the rs1976667 and rs2684788 loci were significantly associated with genetic susceptibility to ISS (P = 0.03636 and P = 0.01352, respectively). Stratification by sex revealed that in males, different genotypes at the rs1976667 locus were significantly associated with genetic susceptibility to ISS (P = 0.047), showing G dominant inheritance (P = 0.018). The G allele at the rs2684788 locus was significantly associated with genetic susceptibility to ISS (P = 0.016), showing G dominant inheritance (P < 0.001). In females, different genotypes at the rs1976667 locus were significantly associated with genetic susceptibility to ISS (P = 0.011), showing G dominant inheritance (P = 0.005). Different genotypes at the rs2684788 locus, the G allele, and the G recessive mode of inheritance were all significantly associated with genetic susceptibility to ISS (P < 0.005). The genotypes at the rs1976667 locus in the female ISS group were significantly correlated to IGF-1 standard deviation integral value (SDS) (P = 0.006). The rs1976667 and rs2684788 loci of the human IGF-1R gene are likely associated with different genetic susceptibilities to ISS in males and females. Different clinical phenotypes of ISS may be associated with SNPs of IGF-1R. \u00a9 FUNPEC-RP.",
        "keywords": [
            "Genetic susceptibility",
            "Idiopathic short stature",
            "IGF-1 receptor",
            "Single nucleotide polymorphisms"
        ],
        "venue": "Genetics and Molecular Research",
        "year": 2013,
        "id": "lnSvIs9K"
    },
    "h0EMsqoU": {
        "authors": [
            {
                "name": "W. Yuan",
                "org": ""
            },
            {
                "name": "H. Xu",
                "org": ""
            },
            {
                "name": "J. Zhao",
                "org": ""
            },
            {
                "name": "W. Ding",
                "org": ""
            },
            {
                "name": "H. Jiang",
                "org": ""
            },
            {
                "name": "M. Gu",
                "org": ""
            },
            {
                "name": "J. Xue",
                "org": ""
            },
            {
                "name": "J. Chen",
                "org": ""
            },
            {
                "name": "F. Fang",
                "org": ""
            },
            {
                "name": "Z. Chen",
                "org": ""
            },
            {
                "name": "L. Jin",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            }
        ],
        "title": "Information behavior of microsatellite loci in genome scanning",
        "abstract": "Objective: To determine the heterozygosity and polymorphism information content of 139 microsatellite loci in Han population. Methods: Multiplex approach was used to analyze the 139 loci. The amplified fragments were subjected to electrophoresis in PAGE gel and analyzed with Genescan(TM) and Genotyper(TM). Results: The heterozygosities are between 0.35 to 0.89, with the heterozygosites of 88% loci >0.60. PICs are in the range of 0.32 and 0.88, with PICs of 95% loci> 0.50. Conclusion: The polymorphism information content of microsatellite loci is very high and their distribution varies in different races and populations.",
        "keywords": [
            "Heterozygosity",
            "Microsatellite locus",
            "Polymerase chain reaction",
            "Polymorphism information content"
        ],
        "venue": "Chinese Journal of Medical Genetics",
        "year": 2000,
        "id": "h0EMsqoU"
    },
    "oDfgx8Km": {
        "authors": [
            {
                "name": "T.S. Xu",
                "org": "Tropical Crop Genetic Resource Research Institute"
            },
            {
                "name": "X.L. Liu",
                "org": "The College of Animal Science and Technology"
            },
            {
                "name": "W. Huang",
                "org": "The Institute of Animal Science (IAS)"
            },
            {
                "name": "S.S. Hou",
                "org": "The Institute of Animal Science (IAS)"
            }
        ],
        "title": "Estimates of genetic parameters for body weight and carcass composition in Pekin ducks",
        "abstract": "Traditional force feed technology produced excessive fat ducks and could not meet the wide range needs. This study studied the possibility of breeding muscular Pekin duck. Data collection was performed in an experimental Pekin duck line. At 7 weeks of age, 1,985 ducks were selected according to their pedigree to measure the traits studied in this study. Single and multiple trait analyses were used to estimated heritability and variance components by restricted maximum likelihood. Heritability estimation of Body Weight (BW), Keel Length (KL), Breast Breadth (BB) and Breast Meat Thickness (BMT) were moderate to high (0.20-0.53). The heritability for Breast Muscle Weight (BMW) and Breast Meat Percentage (BMP) were 0.50 and 0.47, respectively suggesting an increase of breast meat development could be achieved by selection. The heritability of Abdominal Fat Weight (AFW), Abdominal Fat Percentage (AFP), Leg Muscle Weight (LMW) and Leg Muscle Percentage (LMP) were 0.23, 0.32, 0.38 and 0.16, respectively. The genetic correlation between BW and those of BMW and BMP were 0.74 and 0.25. Which suggest that BMP, not BMW may be a selection criterion for muscular Pekin duck. The genetic correlation between BMP and those of KL, BB and BMT were 0.69, 0.69 and 0.71, respectively. The genetic correlation between BMP and AFP was -0.03, therefore body size traits could be used as the selection index for improving the BMP and selecting for higher BMP should not decrease the leanness. In conclusion, higher BMP and lower AFP Pekin duck could be achieved. \u00a9 Medwell Journals, 2011.",
        "keywords": [
            "Body size",
            "Body weight",
            "Carcass composition",
            "Correlation",
            "Genetic parameter",
            "Pekin duck"
        ],
        "venue": "Journal of Animal and Veterinary Advances",
        "year": 2011,
        "id": "oDfgx8Km"
    },
    "4agXO49S": {
        "authors": [
            {
                "name": "M. Xie",
                "org": "Institute of Animal Science"
            },
            {
                "name": "S.S. Hou",
                "org": "Institute of Animal Science"
            },
            {
                "name": "W. Huang",
                "org": "Institute of Animal Science"
            },
            {
                "name": "L. Zhao",
                "org": "Institute of Animal Science"
            },
            {
                "name": "J.Y. Yu",
                "org": "Institute of Animal Science"
            },
            {
                "name": "W.Y. Li",
                "org": "Institute of Animal Science"
            },
            {
                "name": "Y.Y. Wu",
                "org": "Institute of Animal Science"
            }
        ],
        "title": "Interrelationship between methionine and cystine of early Peking ducklings",
        "abstract": "A 4 x 5 factorial experiment containing 4 cystine levels (0.325, 0.406, 0.487, or 0.568%) and 5 methionine levels (0.285, 0.385, 0.485, 0.585, or 0.685%) was conducted to evaluate the interrelationship between methionine and cystine in corn-peanut meal diet for Peking ducklings from hatch to 21 d of age. Eight hundred 1-d-old male white Peking ducklings were assigned to 20 experimental treatments. All treatments were replicated 4 times using 10 ducklings per pen. As dietary methionine level increased, weight gain and feed intake increased and then decreased; the quadratic response of weight gain was significant (P < 0.05). The methionine requirement for maximum efficiency of feed utilization (0.585%) was higher than for maximum weight gain (0.485%). According to the quadratic model, the optimal methionine requirement of Peking ducklings from hatch to 21 d of age was 0.481% (95% of the level at maximum response). The plasma uric acid concentration was very low (P < 0.05) when dietary methionine was 0.485%. When dietary methionine was excessive (0.685%), the plasma homocysteine concentration increased (P < 0.05). On the other hand, the cystine requirement of ducklings from hatch to 21 d of age was not more than 0.325%. A high level of cystine (0.568%) depressed weight gain and feed intake (P < 0.05), but cystine supplementation in the diets lowered the plasma homocysteine concentration (P < 0.05). There were no significant interactions between methionine and cystine on growth performance, plasma uric acid, and plasma homocysteine. \u00a92004 Poultry Science Association, Inc.",
        "keywords": [
            "Cystine",
            "Duckling",
            "Methionine"
        ],
        "venue": "Poultry Science",
        "year": 2004,
        "id": "4agXO49S"
    },
    "zlSxrsom": {
        "authors": [
            {
                "name": "M. Xie",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "J.N. Zhao",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "S.S. Hou",
                "org": "State Key Laboratory of Animal Nutrition"
            },
            {
                "name": "W. Huang",
                "org": "State Key Laboratory of Animal Nutrition"
            }
        ],
        "title": "The apparent metabolizable energy requirement of White Pekin ducklings from hatch to 3 weeks of age",
        "abstract": "A dose-response experiment with 5 dietary energy levels (10.26, 10.88, 11.50, 12.14, and 12.75 MJ AME/kg) was conducted to estimate the apparent metabolizable energy requirement of White Pekin ducklings from hatch to 3 weeks of age. A total of 280 one-day-old male White Pekin ducklings were assigned to 5 experimental treatments, each containing 8 replicate pens with 7 birds per pen. These ducklings were reared in raised wire-floor pens from hatch to 21 days of age. At 21 days of age, the weight gain, feed intake, energy intake, protein intake, feed conversion efficiency, and the yields of abdominal fat, breast meat, and leg meat of ducklings from each treatment were measured. As dietary energy level increased from 10.26 to 12.75 MJ AME/kg, the weight gain of ducklings increased (P<0.01) and the feed intake, feed conversion efficiency and protein intake decreased (P<0.01), but the energy intake did not change (P>0.05). According to the broken-line regression analysis, the AME requirement of White Pekin ducklings from hatch to 3 weeks of age for optimal feed conversion efficiency was 12.63 MJ/kg when dietary protein was 205 g/kg. A high dietary energy content did not affect (P>0.05) the percentage of breast and leg meat in the carcass but the percentage of abdominal fat increased (P<0.01) as dietary energy level increased. Crown Copyright \u00a9 2010.",
        "keywords": [
            "Duckling",
            "Energy",
            "Requirement"
        ],
        "venue": "Animal Feed Science and Technology",
        "year": 2010,
        "id": "zlSxrsom"
    },
    "lHWGP4Rd": {
        "authors": [
            {
                "name": "X. He",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Ding Liang Zhu",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Shao Li Chu",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "L. Jin",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Mo Miao Xiong",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Gu Liang Wang",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Wei Zhong Zhang",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Hai Fa Zhou",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Shou Yu Mao",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Yi Ming Zhan",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Qi Nan Zhuang",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Xiao Ming Liu",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "Y. Zhao",
                "org": "Shanghai Institute of Hypertension"
            },
            {
                "name": "W. Huang",
                "org": "Shanghai Institute of Hypertension"
            }
        ],
        "title": "\u03b1-adducin gene and essential hypertension in China",
        "abstract": "Adducin is a membrane skeletal protein that is involved in the regulation of membrane ion transport and cellular signal transduction. Essential hypertension has been linked to \u03b1-adducin gene locus, and association of a polymorphism of the gene has been found in some studies, but results of linkage or association studies on \u03b1-adducin gene are controversial among different populations. This study was designed to examine the linkage between \u03b1-adducin gene locus and essential hypertension and to reveal the relationship between an \u03b1-adducin gene polymorphism (Gly460Trp) and essential hypertension in a Chinese population. For the linkage study, one hundred and six Chinese nuclear families were recruited, including 417 hypertensive patients in all 474 individuals. Those samples were genotyped at D4S412 and D4S3038. The distances between the two microsatellite markers and the \u03b1-adducin gene locus are less than 3cM. Parametric, non-parametric linkage (NPL) analyses using the GENEHUNTER software were carried out. Sib transmission-disequilibrium test (S-TDT), as well as transmission-disequilibrium test (TDT), was also implemented with TDT/S-TDT Program 1.1. Serum levels of uric acid, creatinine, blood urea nitrogen (BUN), fasting glucose and lipids were determined as phenotypes. In an association study, 138 hypertensive and 121 normotensive subjects were genotyped at Gly460Trp of the \u03b1-adducin gene to examine a possible association between this polymorphism and blood pressure or other phenotypes. We fail to find the linkage between the two markers and essential hypertension by parametric, NPL analysis or TDT/S-TDT study. With the use of the simple association and the multivariate logistic regression analyses, we also fail to reveal a significant association between the Gly460Trp polymorphism in \u03b1-adducin gene and the blood pressure variation, or blood biochemical indices studied. The frequency of the 460Trp allele in Chinese (46-48%) is similar to that found in Japanese (54-60%) while the allele frequency is less common in Caucasian (13%-23%). These findings suggest that in our Chinese population, \u03b1-adducin 460Trp variant may not play an important role in the etiology of EH. And the negative results of linkage and TDT/ S-TDT further supports this conclusion.",
        "keywords": [
            "\u03b1-adducin",
            "Genetics",
            "Hypertension"
        ],
        "venue": "Clinical and Experimental Hypertension",
        "year": 2001,
        "id": "lHWGP4Rd"
    },
    "aoPu1Qqy": {
        "id": "aoPu1Qqy",
        "title": "Effect of Cold Working and Aging Treatment on Mechanical Performance of SS316LN Tube",
        "abstract": "AbstractModified stainless steel 316LN is selected as a candidate material for the China Fusion Engineering Test Reactor (CFETR) central solenoid model coil (CSMC) because of the high strength combined with good ductility at cryogenic temperature. The tensile properties, fatigue crack growth rate, and fracture toughness of the SS316LN tube in solution-annealed and aged (575\u00b0C/100\u00a0h and 650\u00b0C/100\u00a0h) conditions were evaluated at 4.2\u00a0K. The fatigue crack growth and tensile properties for the solution-annealed conduit were high enough to satisfy the design requirements for CFETR CSMC. However, the fracture toughness of the aged conduit is not satisfied, since there was a significant decline from 280 to 110\u00a0MPa\u00b7m1/2 after cold working and aging treatments. The chemical compositions and fractures have been analyzed to assess the reason and recommend modifications that could improve fracture toughness and fatigue crack growth properties.",
        "keywords": "",
        "authors": [
            {
                "name": "Huan Jin",
                "org": " Chinese Academy of Sciences, Institute of Plasma Physics, Hefei, 230031, P. R. China"
            },
            {
                "name": "Yanxia Wu",
                "org": ""
            },
            {
                "name": "Jinggang Qin",
                "org": " Chinese Academy of Sciences, Institute of Plasma Physics, Hefei, 230031, P. R. China"
            },
            {
                "name": "Feng Liu",
                "org": " Chinese Academy of Sciences, Institute of Plasma Physics, Hefei, 230031, P. R. China"
            },
            {
                "name": "Feng Long",
                "org": " Chinese Academy of Sciences, Institute of Plasma Physics, Hefei, 230031, P. R. China"
            },
            {
                "name": "M. Yu",
                "org": " Chinese Academy of Sciences, Institute of Plasma Physics, Hefei, 230031, P. R. China"
            },
            {
                "name": "Qiyang Han",
                "org": " Chinese Academy of Sciences, Institute of Plasma Physics, Hefei, 230031, P. R. China"
            },
            {
                "name": "C. Huang",
                "org": " Chinese Academy of Sciences, Technical Institute of Physics and Chemistry, Beijing, 100190, P. R. China"
            }
        ],
        "venue": "Fusion Science and Technology",
        "year": 2018
    },
    "CAJQ4obM": {
        "id": "CAJQ4obM",
        "title": "Observation of reversible critical current performance under large compressive strain in Sr0.6K0.4Fe2As2 tapes",
        "abstract": "Iron-based superconductors have caused great interest regarding high-field applications due to their good properties. A common fabrication route for 122-type wires and tapes is the ex situ powder-in-tube (PIT) process. From the point of application in the high magnetic field, where high electromagnetic forces are present, the conductor strength and its tolerance to the mechanical load are important issues. In order to understand the comparatively integrated critical current characterization of the Sr-122 tape under axial strain, the so-called U-spring setup was used to test a silver-sheathed Sr0.6K0.4Fe2As2 tape sample with a single core over a wide range of applied axial strain (-0.6% \u223c 0.3%). It was found that when the sample was compressed, the critical current performance showed reversiblity; meanwhile the irreversible tensile strain limit was quite low. The Sr-122/Ag tape shows very good performance under compression, and a possible conductor design should be considered to make the superconductor work at proper compressive strain states for future applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Feng Liu",
                "org": ""
            },
            {
                "name": "Chao Yao",
                "org": "Key laboratory of Applied Superconductivity, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, People\u2019s Republic of China"
            },
            {
                "name": "Hongrui Liu",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "Chao Dai",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "Jinggang Qin",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "L Ci",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "Zhehua Mao",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "Chao Zhou",
                "org": "University of Twente, Netherlands"
            },
            {
                "name": "Yuejiang Shi",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "Huan Jin",
                "org": "Institute of Plasma Physics, Chinese Academy of Sciences, Hefei, People\u2019s Republic of China"
            },
            {
                "name": "Dongliang Wang",
                "org": ""
            },
            {
                "name": "Yonghui Ma",
                "org": "Key laboratory of Applied Superconductivity, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing, People\u2019s Republic of China"
            }
        ],
        "venue": "Superconductor Science and Technology",
        "year": 2017
    },
    "UJjpEFy1": {
        "id": "UJjpEFy1",
        "title": "miR-200bc/429 cluster modulates multidrug resistance of human cancer cell lines by targeting BCL2 and XIAP.",
        "abstract": "MicroRNAs (miRNAs) are short non-coding RNA molecules, which post-transcriptionally regulate genes expression and play crucial roles in diverse biological processes. Recent studies have shown that dysregulation of miRNAs might modulate the resistance of cancer cells to anti-cancer drugs, yet the modulation mechanism is not fully understood. We aimed to investigate the possible role of miRNAs in the development of multidrug resistance (MDR) in human gastric and lung cancer cell lines.miRNA Quantitative real-time PCR was used to detect the different miRNA expression levels between drug resistant and parental cancer cells. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to test the drug-resistant phenotype changes in cancer cells via over or downregulation of miRNAs. Dual-luciferase activity assay was used to verify the target genes of miRNAs. Western blot analysis and apoptosis assay were used to elucidate the mechanism of miRNAs on modulating drug resistance in cancer cells.miR-200bc/429 cluster was downregulated, while BCL2 and XIAP were upregulated in both MDR SGC7901/VCR (vincristine) and A549/CDDP (cisplatin) cells, compared with the parental SGC7901 and A549 cells, respectively. Overexpression of miR-200bc/429 cluster sensitized SGC7901/VCR and A549/CDDP cells to anti-cancer drugs, respectively. Both BCL2 and XIAP 3'-UTR reporters constructed in MDR cells suggested that BCL2 and XIAP were the common target genes of the miR-200bc/429 cluster. Enforced miR-200bc/429 cluster expression reduced BCL2 and XIAP protein level and sensitized both MDR cells to VCR-induced and CDDP-induced apoptosis, respectively.Our findings first suggest that miR-200bc/429 cluster could play a role in the development of MDR in both gastric and lung cancer cell lines, at least in part by modulation of apoptosis via targeting BCL2 and XIAP.",
        "keywords": [
            "bcl2",
            "mir-200bc/429 cluster",
            "multidrug resistance",
            "xiap"
        ],
        "authors": [
            {
                "name": "Wei Zhu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Huaguo Xu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "DanXia Zhu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Hui Zhi",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tongshan Wang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jian Wang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Binghua Jiang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Yongqian Shu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ping Liu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Cancer chemotherapy and pharmacology",
        "year": 2012
    },
    "mtuKqUQn": {
        "id": "mtuKqUQn",
        "title": "miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin by targeting Bcl-2.",
        "abstract": "Drug resistance is one of the leading causes of chemotherapy failure in cancer treatment. MicroRNAs (miRNAs or miRs) are short non-coding RNA molecules that post-transcriptionally regulate gene expression and play a critical role in diverse biological processes. In this study, we report that miR-503 regulates the resistance of non-small cell lung cancer cells to cisplatin. The expression of miR-503 was decreased in the cisplatin-resistant non-small cell lung cancer cells, A549/CDDP, compared with the parental A549 cells. The overexpression of miR-503 sensitized the A549/CDDP cells to cisplatin, whereas the inhibition of miR-503 in the A549 cells increased resistance to cisplatin. Mechanistically, miR-503 specifically targeted Bcl-2, an anti-apoptotic protein upregulated in the A549/CDDP cells. The ectopic expression of miR-503 reduced the Bcl-2 protein level and sensitized the A549/CDDP cells to cisplatin-induced apoptosis. Taken together, our results suggest that miR-503 regulates cell apoptosis, at least in part by targeting Bcl-2, and thus modulates the resistance of non-small cell lung cancer cells to cisplatin.",
        "keywords": [
            "lung cancer",
            "cisplatin resistance",
            "apoptosis",
            "mir-503",
            "bcl-2",
            "cell",
            "gene",
            "cell cycle",
            "molecular medicine",
            "oncology",
            "cancer"
        ],
        "authors": [
            {
                "name": "Tianzhu Qiu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Li Zhou",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tongshan Wang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jing Xu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jian Wang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Wenjiao Chen",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Xin Zhou",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Zebo Huang",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Wei Zhu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Yongqian Shu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ping Liu",
                "org": "Nanjing Medical University(Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "International journal of molecular medicine",
        "year": 2013
    },
    "1iNvlErl": {
        "id": "1iNvlErl",
        "title": "miR-135a/b modulate cisplatin resistance of human lung cancer cell line by targeting MCL1.",
        "abstract": "microRNAs (miRNAs) are short non-coding RNA molecules, which post-transcriptionally regulate genes expression and play crucial roles in diverse biological processes, such as development, differentiation, apoptosis, and proliferation. Here, we investigated the possible role of miRNAs in the development of drug resistance in human lung cancer cell line. We found that miR-135a/b were downregulated while MCL1 was upregulated in A549/CDDP (cisplatin) cells, compared with the parental A549 cells. In vitro drug sensitivity assay demonstrated that overexpression of miR-135a/b sensitized A549/CDDP cells to cisplatin. The luciferase activity of MCL1 3'-untranslated region-based reporter constructed in A549/CDDP cells suggested that MCL1 was the direct target gene of miR-135a/b. Enforced miR-135a/b expression reduced MCL1 protein level and sensitized A549/CDDP cells to CDDP-induced apoptosis. Taken together, our findings first suggested that hsa-miR-135a/b could play a role in the development of CDDP resistance in lung cancer cell line at least in part by modulation of apoptosis via targeting MCL1.",
        "keywords": [
            "lung cancer",
            "cisplatin resistance",
            "apoptosis",
            "mcl1",
            "mir-135a/b"
        ],
        "authors": [
            {
                "name": "Li Zhou",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tianzhu Qiu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jing Xu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Tongshan Wang",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Jian Wang",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Xin Zhou",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Zebo Huang",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Wei Zhu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Yongqian Shu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            },
            {
                "name": "Ping Liu",
                "org": "Hospital of Nanjing Medical University(Hospital of Nanjing Medical University,First Affiliated Hospital of Nanjing Medical University),Nanjing,China"
            }
        ],
        "venue": "Pathology oncology research : POR",
        "year": 2013
    },
    "hIZi491z": {
        "id": "hIZi491z",
        "title": "miR-497 modulates multidrug resistance of human cancer cell lines by targeting BCL2.",
        "abstract": "MicroRNAs (miRNAs) are short non-coding RNA molecules, which posttranscriptionally regulate genes expression and play crucial roles in diverse biological processes, such as development, differentiation, apoptosis, and proliferation. Here, we investigated the possible role of miRNAs in the development of multidrug resistance (MDR) in human gastric and lung cancer cell lines. We found that miR-497 was downregulated in both multidrug-resistant human gastric cancer cell line SGC7901/vincristine (VCR) and multidrug-resistant human lung cancer cell line A549/cisplatin (CDDP) and the downregulation of miR-497 was concurrent with the upregulation of BCL2 protein, compared with the parental SGC7901 and A549 cell lines, respectively. In vitro drug sensitivity assay demonstrated that overexpression of miR-497 sensitized SGC7901/VCR and A549/CDDP cells to anticancer drugs, respectively. The luciferase activity of BCL2 3'-untranslated region-based reporter constructed in SGC7901/VCR and A549/CDDP cells suggested that BCL2 was the direct target gene of miR-497. Enforced miR-497 expression reduced BCL2 protein level and sensitized SGC7901/VCR and A549/CDDP cells to VCR-induced and CDDP-induced apoptosis, respectively. Taken together, our findings first suggested that has-miR-497 could play a role in both gastric and lung cancer cell lines at least in part by modulation of apoptosis via targeting BCL2.",
        "keywords": [
            "mir-497 \ufffd multidrug resistancebcl2 abbreviations"
        ],
        "authors": [
            {
                "name": "Wei Zhu",
                "org": "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "DanXia Zhu",
                "org": "Department of Haematology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Shiqiang Lu",
                "org": "Department of Microbiology and Immunology, Nanjing Medical University, 140 Hanzhong Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Tongshan Wang",
                "org": "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Jian Wang",
                "org": "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Binghua Jiang",
                "org": "Cancer Center of Nanjing Medical University, 140 Hanzhong Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Yongqian Shu",
                "org": "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029 Nanjing, People\u2019s Republic of China"
            },
            {
                "name": "Ping Liu",
                "org": "Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029 Nanjing, People\u2019s Republic of China"
            }
        ],
        "venue": "Medical oncology (Northwood, London, England)",
        "year": 2012
    },
    "1apZ75v5": {
        "authors": [
            {
                "name": "M. Yang",
                "org": "Department of Orthopedics"
            },
            {
                "name": "Qing-Jun Ma",
                "org": "Department of Orthopedics"
            },
            {
                "name": "G.T. Dang",
                "org": "Department of Orthopedics"
            },
            {
                "name": "K.T. Ma",
                "org": "Department of Biochemistry and Molecular Biology"
            },
            {
                "name": "P. Chen",
                "org": "Department of Biochemistry and Molecular Biology"
            },
            {
                "name": "Chun-Yan Zhou",
                "org": "Department of Biochemistry and Molecular Biology"
            }
        ],
        "title": "In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7",
        "abstract": "Background: Adipose-derived adult stem (ADAS) cells are multipotent cells capable of differentiating into osteoblasts, adipocytes and chondrocytes. The aim of this study was to determine whether BMP-7-expressing ADAS cells would elicit bone formation in vitro and in vivo. Methods: ADAS cells were harvested from Lewis rats and transduced with adenovirus carrying the recombinant human bone morphogenetic protein-7 (Ad-BMP-7) gene. Untransduced cells and cells transduced with adenovirus carrying the enhanced green fluorescence protein (Ad-EGFP) gene served as controls. BMP-7 expression was assessed by RT-PCR, immunofluorescence on day 1, and Western blot on days 4, 8 and 12. Alkaline phosphatase (ALP) activity was assayed on days 2, 4, 6, 8, 10 and 12. Osteocalcin production and bone nodule formation were detected by immunohistochemistry and von Kossa stain on day 12. A total of 1 \u00d7 10",
        "keywords": [
            "Adipose-derived adults stem cells",
            "BMP-7",
            "Differentiation",
            "Gene therapy"
        ],
        "venue": "Cytotherapy",
        "year": 2005,
        "id": "1apZ75v5"
    },
    "fivPsCSs": {
        "authors": [
            {
                "name": "Y.-P. Wu",
                "org": "Department of Dermatology"
            },
            {
                "name": "Z.-Y. Jin",
                "org": "Department of Dermatology"
            },
            {
                "name": "H.-P. Feng",
                "org": "Department of Dermatology"
            },
            {
                "name": "C.-L. Zhang",
                "org": "Department of Dermatology"
            },
            {
                "name": "M.-L. Ge",
                "org": "Department of Dermatology"
            },
            {
                "name": "Q. Jia",
                "org": "Department of Dermatology"
            },
            {
                "name": "M. Yang",
                "org": "Department of Dermatology"
            }
        ],
        "title": "Clinical study on treatment of condyloma acuminata with 0.5% podophyllotoxin film",
        "abstract": "OBJECTIVE: To explore the clinical efficacy and safety of 0.5% podophyllotoxin film in the treatment of condyloma acuminata. METHOD: 50 patients with condyloma acuminata were randomly assigned into two groups, one treated with 0.5% podophyllotoxin film, another with 0.5% podophyllotoxin tincture for external use with the duration of 7 \u223c 28 days. RESULTS: The results showed that the cure rate of 0.5% podophyllotoxin film group was similar (P > 0.05) and the side effects were less (P < 0.01) in comparison with the control group. CONCLUSION: 0.5% podophyllotoxin film can be effectively and safely used in the treatmeat of patients with condyloma acuminata.",
        "keywords": [
            "Condyloma acuminata",
            "Efficacy",
            "Podophyllotoxin film",
            "Safety"
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2001,
        "id": "fivPsCSs"
    },
    "gpNLQc2S": {
        "authors": [
            {
                "name": "X. Zhang",
                "org": "Department of Sports Medicine"
            },
            {
                "name": "M. Yang",
                "org": "Department of Orthopedics"
            },
            {
                "name": "L. Lin",
                "org": "Department of Sports Medicine"
            },
            {
                "name": "P. Chen",
                "org": "Department of Biochemistry and Molecular Biology"
            },
            {
                "name": "K.T. Ma",
                "org": "Department of Biochemistry and Molecular Biology"
            },
            {
                "name": "C.Y. Zhou",
                "org": "Department of Biochemistry and Molecular Biology"
            },
            {
                "name": "Y.F. Ao",
                "org": "Department of Sports Medicine"
            }
        ],
        "title": "Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose - Derived stem cells in vitro and in vivo",
        "abstract": "Like bone marrow stromal cells, adipose tissue-derived stem cells (ADSCs) possess multilineage potential, a capacity for self-renewal and long-term viability. To confirm whether ADSCs represent a promising source of cells for gene-enhanced bone tissue-engineering, the osteogenic potential of ADSCs under the control of certain osteoinductive genes has been evaluated. Runx2, a transcription factor at the downstream end of bone morphogenetic protein (BMP) signaling pathways, is essential for osteoblast differentiation and bone formation. In this study we used adenovirus vector to deliver Runx2 to ADSCs and then examined the enhancement of osteogenic activity. Overexpression of Runx2 inhibited adipogenesis, as demonstrated by suppression of LPL and PPAR\u03b3 expression at the mRNA level and reduced lipid droplet formation. Moreover, ADSCs transduced with Ad-Runx2 underwent rapid and marked osteoblast differentiation as determined by osteoblastic gene expression, alkaline phosphatase activity and mineral deposition. Additionally, histological examination revealed that implantation of Runx2 modified ADSCs could induce mineral deposition and bone-like tissue formation in vivo. These results confirmed, firstly, the ability of Runx2 to promote osteogenesis and cell differentiation and, secondly, the competence of ADSCs as target cells for bone tissue engineering. Our work demonstrates a potential new approach for bone repair using Runx2-modified ADSCs for bone tissue engineering. \u00a9 2006 Springer Science+Business Media, Inc.",
        "keywords": [
            "Adipose-derived stem cells",
            "Differentiation",
            "Gene therapy",
            "Osteogenesis",
            "Runx2"
        ],
        "venue": "Calcified Tissue International",
        "year": 2006,
        "id": "gpNLQc2S"
    },
    "F6pU8QQ1": {
        "authors": [
            {
                "name": "J.W. Yu",
                "org": "SKLEAC"
            },
            {
                "name": "Y.M. Zhao",
                "org": "SKLEAC"
            },
            {
                "name": "M. Yang",
                "org": "SKLEAC"
            },
            {
                "name": "Tsair-Fuh Lin",
                "org": "Department of Environmental Engineering"
            },
            {
                "name": "Z.H. Guo",
                "org": "SKLEAC"
            },
            {
                "name": "J.N. Gu",
                "org": "Beijing Waterworks (Group) Co., Ltd."
            },
            {
                "name": "S. Li",
                "org": "Beijing Capital Co., Ltd."
            },
            {
                "name": "W. Han",
                "org": "Beijing Capital Co., Ltd."
            }
        ],
        "title": "Occurrence of odour-causing compounds in different source waters of China",
        "abstract": "In this study, occurrence of the main odorous compounds in different types of source water in China, including rivers, lakes and reservoirs, were investigated by integrating the methods of flavour profile analysis (FPA) and sensory-GC/MS analysis. Simultaneous distillation extraction (SDE) was chosen as the preconcentration technique while the odour-causing compounds were identified with sensory-GC/MS. It was found that MIB, which is mainly produced by some cyanobacteria and actinomycetes, was one of the most widely distributed odour-causing compounds, regardless of source type. A peak MIB concentration of approximately 170 ng l",
        "keywords": [
            "Bis(2-chloroisopropyl) ether",
            "Dimethyl trisulfide",
            "Geosmin",
            "MIB",
            "Sensory-GC/MS"
        ],
        "venue": "Journal of Water Supply: Research and Technology - AQUA",
        "year": 2009,
        "id": "F6pU8QQ1"
    },
    "QKhM9inO": {
        "authors": [
            {
                "name": "S.Y. Wang",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "M. Yang",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "X.P. Xu",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "G.F. Qiu",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "J. Ma",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "S.J. Wang",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "X.X. Huang",
                "org": "Institute of Clinical Laboratory Science"
            },
            {
                "name": "Hua-Xi Xu",
                "org": "Institute of Clinical Laboratory Science"
            }
        ],
        "title": "Intranasal delivery of T-bet modulates the profile of helper T cell immune responses in experimental asthma",
        "keywords": [
            "Allergy",
            "Immune response",
            "Modulation",
            "T h1/th2",
            "Transcription factor"
        ],
        "venue": "Journal of Investigational Allergology and Clinical Immunology",
        "year": 2008,
        "id": "QKhM9inO"
    },
    "G6UsoZ2K": {
        "authors": [
            {
                "name": "S.J. Zhang",
                "org": "Stt. Key Lab. Environ. Aquatic Chem."
            },
            {
                "name": "M. Yang",
                "org": "Stt. Key Lab. Environ. Aquatic Chem."
            },
            {
                "name": "Q.X. Yang",
                "org": "Stt. Key Lab. Environ. Aquatic Chem."
            },
            {
                "name": "Y. Zhang",
                "org": "Stt. Key Lab. Environ. Aquatic Chem."
            },
            {
                "name": "B.P. Xin",
                "org": "Stt. Key Lab. Environ. Aquatic Chem."
            },
            {
                "name": "F. Pan",
                "org": "Stt. Key Lab. Environ. Aquatic Chem."
            }
        ],
        "title": "Biosorption of reactive dyes by the mycelium pellets of a new isolate of Penicillium oxalicum",
        "abstract": "Three reactive dyes were rapidly adsorbed by the mycelium pellets of Penicillium oxalicum. Dye removal of Reactive Blue 19 was up to 60% in 10 min and 91% in 80 min. Dye adsorption isotherms fitted Langmuir model well and the maximum adsorption capacities at 20\u00b0C were calculated to be 160 mg g ",
        "keywords": [
            "Biosorption",
            "Decolorization",
            "Mycelium pellets",
            "Penicillium oxalicum",
            "Reactive dyes"
        ],
        "venue": "Biotechnology Letters",
        "year": 2003,
        "id": "G6UsoZ2K"
    },
    "n7Cs75hw": {
        "authors": [
            {
                "name": "Y.-H. Fu",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "Q.-X. Lin",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "X.-H. Li",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "H.-W. Fei",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "Z.-X. Shan",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "X.-Z. Huang",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "X.-Y. Liu",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "M. Yang",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "S.-G. Lin",
                "org": "Guangdong General Hospital"
            },
            {
                "name": "Shu-Feng Zhou",
                "org": "Discipline of Chinese Medicine"
            },
            {
                "name": "Y.-Y. Zhang",
                "org": "Institute of Vascular Medicine"
            },
            {
                "name": "Xi-Yong Yu",
                "org": "Guangdong General Hospital"
            }
        ],
        "title": "A novel rat model of chronic heart failure following myocardial infarction",
        "abstract": "In this report, we describe an improved method for the establishment of reproducible congestive heart failure (CHF) in a rat model. The area of myocardial infarction (MI) after ligation of the left anterior descending (LAD) coronary artery was quantified. Histological changes, heart function detected by echocardiography and isolated Langendorff perfusion, and selected biochemical factors were monitored after ligation of the LAD. Contrary to previous beliefs, thoracotomy in the second intercostal space provided a much better visualization of and easier access to the LAD and significantly reduced the mortality rate. Surface electrocardiogram (ECG) showed that the S-T interval was arched raised upward immediately after ligation. Typical morphological and functional changes of CHF were observed after LAD ligation. Cardiomyocytes in the infarcted zone were depleted and deranged. Biochemical analysis and enzyme-linked immunosorbent assay (ELISA) showed that superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and nitric oxide (NO) levels were significantly lowered in rats with MI than in the normal and sham groups, whereas serum malondialdehyde (MDA), MB isoenzyme of creatine kinase (CK-MB), cardiac troponin (cTnT) and C-reactive protein (CRP) levels were elevated. After MI, N-terminal pro-brain natriuretic peptide (NT-proBNP) was increased but insulin-like growth factor I (IGF-I) and vascular endothelial growth factor (VEGF) in culture supernatant were lower than in the normal and sham groups. We present an improved model for maximal reproducibility of experimental CHF in rats which allows the study of molecular and physiological variables in relation to CHF. Copyright \u00a9 2009 Prous Science, S.A.U. or its licensors. All rights reserved.",
        "keywords": [
            "Chronic heart failure",
            "Isolated Langendorff heart perfusion",
            "Myocardial infarct",
            "Rat"
        ],
        "venue": "Methods and Findings in Experimental and Clinical Pharmacology",
        "year": 2009,
        "id": "n7Cs75hw"
    },
    "EQhwnZzF": {
        "authors": [
            {
                "name": "W.L. Ma",
                "org": ""
            },
            {
                "name": "R. Qi",
                "org": ""
            },
            {
                "name": "Y. Zhang",
                "org": ""
            },
            {
                "name": "J. Wang",
                "org": ""
            },
            {
                "name": "C.Z. Liang",
                "org": ""
            },
            {
                "name": "M. Yang",
                "org": ""
            }
        ],
        "title": "Performance of a successive hydrolysis, denitrification and nitrification system for simultaneous removal of COD and nitrogen from terramycin production wastewater",
        "abstract": "A bench-scale continuous flow system, consisting successively of an anaerobic hydrolysis column (column A), an anoxic column (column D) and two aerobic columns (columns B and F), was constructed to remove nitrogen and carbon simultaneously from terramycin crystallization mother solution (TCMS). Columns A and D were sludge-bed reactors, and columns B and F were biofilm reactors packed with polyethylene balls and soft fibers hung on plastic rings, respectively. Approximately 82% of the chemical oxygen demand (COD) and 81% total nitrogen were removed by the system when tap water diluted TCMS was continuously fed (dilution ratio, 1:4). Sulfide which was produced during anaerobic hydrolysis was used as part of electron donors for denitrification in column D. Comparison results show that porous polyethylene balls had a better COD and NH",
        "keywords": [
            "Antibiotics wastewater",
            "Denitrification",
            "Nitrification",
            "Simultaneous removal of COD and nitrogen"
        ],
        "venue": "Biochemical Engineering Journal",
        "year": 2009,
        "id": "EQhwnZzF"
    },
    "p1ahdSiq": {
        "authors": [
            {
                "name": "C.Y. Deng",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "Shuguang G. Lin",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "W.C. Zhang",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "S.J. Kuang",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "W.M. Qian",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "S.L. Wu",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "Z.X. Shan",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "M. Yang",
                "org": "Research Center of Medical Sciences"
            },
            {
                "name": "X.Y. Yu",
                "org": "Research Center of Medical Sciences"
            }
        ],
        "title": "Esmolol inhibits Na+ current in rat ventricular myocytes",
        "abstract": "Esmolol is a unique cardioselective, intravenous, ultra-short acting, \u03b2",
        "keywords": [
            "Esmolol",
            "Rat ventricular myocytes",
            "Sodium current (INa)",
            "Whole cell patch-clamp technique"
        ],
        "venue": "Methods and Findings in Experimental and Clinical Pharmacology",
        "year": 2006,
        "id": "p1ahdSiq"
    },
    "OXkAbbQn": {
        "authors": [
            {
                "name": "Jun Guo",
                "org": ""
            },
            {
                "name": "Yan Wang",
                "org": ""
            },
            {
                "name": "Zhong-Qiang Chen",
                "org": ""
            },
            {
                "name": "B.W. Liu",
                "org": ""
            },
            {
                "name": "M. Yang",
                "org": ""
            },
            {
                "name": "Z.L. Bai",
                "org": ""
            }
        ],
        "title": "Effect of radiofrequency versus anterior discectomy and posterior lumbar fixation on discogenic low back pain",
        "abstract": "Aim: To compare the curative effect of radiofrequency and anterior discectomy and posterior lumbar fixation on discogenic low back pain. Methods: 1 Fifty-three patients with low back pain and complete clinical data including 33 males and 20 females aged 33-58 years were selected from Department of Orthopaedics, General Hospital of Chinese PLA, and Department of Orthopaedics, the Third Hospital of Peking University between January 1999 and August 2005. Those without obvious root compression, unstable lumbar vertebrae or other lumbar diseases, and accorded with the positive standards of discography complicated by the International Pain Association in 1988 were included. All the patients were informed and agreed to the treatment. 2 The patients were divided into three groups according to different treatments: radiofrequency group (n=21) was given percutaneous puncture radiofrequency vapourization plasty; anterior lumbar interbody fusion group (n=14) was treated with extralperitoneal removal of vertebral disc, Cage implanting combined posterior lumbar fixation with translaminar facet screws and iliac bone graft; posterior lumbar interbody fusion group (n=18) was treated with posterior removal of vertebral disc, Cage implanting combined internal fixation of lumbar spondylolisthesis by pedicle screws and laminar fusion. 3 The operation time and blood loss were recorded and radiology was performed to evaluate fusion condition at one year after operation. The pain degree was evaluated by visual analogue scale (VAS, painless scored 0, and the maximal degree unbearable pain scored 10). Oswestry Disability Index (ODI) was adopted to evaluate the functional improvement (higher scores represented severer functional limitation). All the evaluations were carried out before and 1 year after operation. Improvement rate=[(preoperative score-postoperative score)/preoperative score] \u00d7100%. Grading standards were as follows: excellent: improvement \u2265 75%; very good with 50%-75% improvement; good with 25%-50% improvement; bad with < 25% improvement. 4 Comparison of measurement data was performed with analysis of variance with successive repetitive data measurement. Results: All 53 patients were involved in the result analysis. 1 Comparison of operation duration and blood loss: The operation duration and blood loss of the posterior lumbar interbody fusion group were longer and more than the other groups (P < 0.05); the radiofrequency group was shorter and less than the anterior lumbar interbody fusion group (P < 0.05). 2 Pain improvement after operation: In the radiofrequency group, there were 9 cases with excellent grade, 10 with good and 2 with bad; the pain scores of the anterior and posterior lumbar interbody fusion groups were excellent. The improvement rate of VAS score of the radiofrequency group was significantly lower than the other two groups (P < 0.05). 3 Functional improvement after operation: In the radiofrequency group, there were 5 cases with very good grade, 13 with good and 3 with bad; there were 12 cases with excellent grade and 2 with very good in the anterior lumbar interbody fusion group; in the posterior lumbar interbody fusion group, there were 6 cases with excellent grade, and 12 with very good grade. The ODI functional improvement rate of the radiofrequency group was markedly lower than the other two groups (P < 0.05), and the anterior lumbar interbody fusion group was remarkably higher than the posterior lumbar interbody fusion group (P < 0.05). 4 Vertebral fusion: The fusion rates of the two fusion groups were 100% after 1 year of operation. Conclusion: Radiofreqency has less wound but bad curative effect. The anterior discectomy with translaminar facet screws and posterior discectomy with pedicle screw fixation could effectively relieve the pain; moreover, the former method has a better functional improvement with less wound and is the best choice for the treatment of discogenic low back pain.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2007,
        "id": "OXkAbbQn"
    },
    "PcplltSt": {
        "authors": [
            {
                "name": "Z.X. Shan",
                "org": "Department of Pharmacology"
            },
            {
                "name": "Q.X. Lin",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "M. Yang",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "C.Y. Deng",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "S.J. Kuang",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "Z.L. Zhou",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "D.Z. Xiao",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "X.Y. Liu",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "S.G. Lin",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            },
            {
                "name": "X.Y. Yu",
                "org": "Guangdong Provincial Cardiovascular Diseases Institute"
            }
        ],
        "title": "A quick and efficient approach for gene silencing by using triple putative microRNA-based short hairpin RNAs",
        "abstract": "The RNA interference (RNAi) technique has been widely used in gene function studies. It is typical to screen for effective siRNAs by knocking down targeted genes since a single gene can be suppressed by several siRNAs to varying degrees. The miRNA-based short hairpin RNA (shRNA) is a natural inducer of RNAi and has been used in siRNA expression strategies. We investigated the potential application of multiple putative microRNA-based shRNAs for gene silencing and studied the inhibition efficiency of exogenous GFP and firefly luciferase (luc) by triple human mir155-based shRNA expression vectors. A total of three candidate siRNA sequences targeted against GFP or luc were selected based on an online prediction program. Single and triple miRNA-155-based shRNAs targeted against GFP or luc were transfected into HEK293 cells mediated by the pcDNA",
        "keywords": [
            "CMV promoter",
            "MicroRNAs",
            "RNA interference",
            "Short hairpin RNA"
        ],
        "venue": "Molecular and Cellular Biochemistry",
        "year": 2009,
        "id": "PcplltSt"
    },
    "xmmQR03H": {
        "authors": [
            {
                "name": "W. Qian",
                "org": ""
            },
            {
                "name": "J. Liu",
                "org": ""
            },
            {
                "name": "Y. Tong",
                "org": ""
            },
            {
                "name": "S. Yan",
                "org": ""
            },
            {
                "name": "C. Yang",
                "org": ""
            },
            {
                "name": "M. Yang",
                "org": ""
            },
            {
                "name": "X. Liu",
                "org": ""
            }
        ],
        "title": "Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis",
        "abstract": "Conditionally replicating adenoviruses (CRAds) represent a promising new platform for anticancer therapy. However, CRAds have been evaluated little in hematopoietic malignancies because of the lack of expression of coxsackie adenovirus receptor (CAR) on their cell surface. In this study, we showed that CAR was expressed on two types of lymphoblastic leukemia cell lines and primary leukemia cells, and that ZD55, a CRAd, exerted a potent antileukemia effect in vitro and in vivo. Furthermore, ZD55 expressing melanoma differentiation-associated gene-7/ interleukin-24 (ZD55-IL-24) elicited significant enhanced antileukemia activity comparing with ZD55, concomitant with upregulation of RNA-dependent protein kinase R (PKR), increased phosphorylation of p38 mitogen-activated protein kinase (MAPK), and induction of endoplasmic reticulum (ER) stress. These data for the first time indicate that MDA-7/IL-24 exerts its antitumor effect on leukemia cells via multiple pathways, and suggest that oncolytic adenoviruses, ZD55 and ZD55-IL-24 could potentially be used against CAR-expressing hematological malignancies such as B-lymphoblastic leukemia/lymphoma and some myeloid leukemia.",
        "keywords": [
            ""
        ],
        "venue": "Leukemia",
        "year": 2008,
        "id": "xmmQR03H"
    },
    "mB6r8pgg": {
        "authors": [
            {
                "name": "M. Chen",
                "org": ""
            },
            {
                "name": "S. He",
                "org": ""
            },
            {
                "name": "Q. Yi",
                "org": ""
            },
            {
                "name": "M. Yang",
                "org": ""
            }
        ],
        "title": "Effect of chloride concentration on nitrogen removal from landfill leachate in sequencing batch reactor after MAP pretreatment",
        "abstract": "Leachate generated from landfill is becoming a great environmental challenge to China as it contains high concentration of COD, ammonium and some other substances. Nitrogen removal through the conventional nitrification- denitrification process is hampered by the low C/N ratio especially for the old age landfill sites and the high energy consumption for aeration. In this study, the combination of magnesium ammonium phosphate (MAP) precipitation and Sequencing batch reactor (SBR) was suggested as a new process for the treatment of high strength ammonium, and the effect of high concentration of Cl \n                        ",
        "keywords": [
            "Chloride effect",
            "Landfill leachate",
            "MAP",
            "Nitrogen removal",
            "SBR"
        ],
        "venue": "Water Science and Technology",
        "year": 2010,
        "id": "mB6r8pgg"
    },
    "czIsSvtB": {
        "authors": [
            {
                "name": "D. Inoue",
                "org": "Division of Sustainable Energy and Environmental Engineering"
            },
            {
                "name": "H. Matsui",
                "org": "Advanced Technology R and D Center"
            },
            {
                "name": "K. Sei",
                "org": "Division of Sustainable Energy and Environmental Engineering"
            },
            {
                "name": "J. Hu",
                "org": "College of Environmental Science"
            },
            {
                "name": "M. Yang",
                "org": "State Key Lab. of Environmental Aquatic Chemistry"
            },
            {
                "name": "J. Aragane",
                "org": "Advanced Technology R and D Center"
            },
            {
                "name": "J. Hirotsuji",
                "org": "Advanced Technology R and D Center"
            },
            {
                "name": "M. Ike",
                "org": "Division of Sustainable Energy and Environmental Engineering"
            }
        ],
        "title": "Evaluation of effectiveness of chemical and physical sewage treatment technologies for removal of retinoic acid receptor agonistic activity detected in sewage effluent",
        "abstract": "Retinoic acid receptor (RAR) is a nuclear receptor involved in vertebrate morphogenesis, growth, cellular differentiation, and tissue homeostasis. Excess expression of the retinoid signaling can cause various developmental toxicities in animals and humans. We previously found that influents from sewage treatment plants (STPs) in Japan had a RAR agonistic activity and the activity cannot be removed completely by conventional biological treatments. In this study, we assessed the performance of chemical and physical sewage treatment technologies - ozonation, ultraviolet treatment, chlorination, coagulation using polyaluminium chloride (PAC) and ferric sulfate, and filtration with ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO) membranes - in removal of RAR agonistic activity of STP effluent. All water treatment experiments were conducted in laboratory-scale reactors. The RAR agonistic activity of samples was measured using a yeast two-hybrid assay. Results showed that the effectiveness of tested technologies on the removal of RAR agonistic activity can be ranked as RO or NF > chlorination > ozonation > MF > UV > coagulation with ferric sulfate \u226b coagulation with PAC. Furthermore, the effectiveness of chlorination might rank lower because excess reaction might bring a side effect by producing some RAR agonistic by-product(s). \u00a9 IWA Publishing 2009.",
        "keywords": [
            "Chemical and physical sewage treatment technologies",
            "Effluent",
            "RAR agonistic activity",
            "Retinoic acid receptor (RAR)",
            "Sewage treatment plant"
        ],
        "venue": "Water Science and Technology",
        "year": 2009,
        "id": "czIsSvtB"
    },
    "2CcbkMet": {
        "authors": [
            {
                "name": "Y. Gao",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "D. Xiong",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "M. Yang",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "H. Liu",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "H. Peng",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "X. Shao",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "Y. Xu",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "C. Xu",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "D. Fan",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "L. Qin",
                "org": "Department of Nuclear Medicine"
            },
            {
                "name": "C. Yang",
                "org": "State Key Lab. of Exp. Hematology"
            },
            {
                "name": "Zhenping Zhu",
                "org": "Department of Antibody Technology"
            }
        ],
        "title": "Efficient inhibition of multidrug-resistant human tumors with a recombinant bispecific anti-P-glycoprotein \u00d7 anti-CD3 diabody",
        "keywords": [
            "Antibody engineering",
            "Bispecific antibody",
            "Cancer therapy",
            "CD3",
            "Cytotoxic cell targeting",
            "Diabody",
            "Multidrug resistance",
            "P-glycoprotein"
        ],
        "venue": "Leukemia",
        "year": 2004,
        "id": "2CcbkMet"
    },
    "7GjEhN2M": {
        "authors": [
            {
                "name": "Ning Yang",
                "org": "State Key Laboratory of Petroleum Resource and Prospecting"
            },
            {
                "name": "Guiwen Wang",
                "org": "College of Geosciences"
            },
            {
                "name": "Jin Lai",
                "org": "State Key Laboratory of Petroleum Resource and Prospecting"
            },
            {
                "name": "Jianlun Li",
                "org": "State Key Laboratory of Petroleum Resource and Prospecting"
            },
            {
                "name": "Bin Zhao",
                "org": "CNPC Logging Co. Ltd"
            },
            {
                "name": "Qijun Jiang",
                "org": "Sino Geophysical CO. LTD"
            },
            {
                "name": "Zhi Wang",
                "org": "Geophysical Research Institute of Jilin Oilfield"
            }
        ],
        "title": "Productivity evaluation of low porosity and low permeability reservoirs using differential pressure method: an example from the Cretaceous Bashijiqike Formation in Dabei area, the Tarim Basin",
        "abstract": "The Lower Cretaceous Bashijiqike Formation in Dabei area of Tarim Basin is a typical fractured tight sandstone reservoir with dual porosity structure consisting of low porosity and permeability matrix and fractures. This kind of dual porosity structure results in complex gas-water contact in the reservoir. It is always difficult to evaluate the productivity of this kind of reservoir by using the traditional geological and logging methods. Based on the theory of seepage mechanics, we believe that the formation pressure difference and capillary pressure are the parameters controlling productivity. The fluid can be produced from the porous media only when the formation differential pressure overtakes the resistance of capillary pressure generated by reservoir fluids of different phases. Based on analysis of a large amount of mercury injection data, we built a model through multiple regression analysis for calculating average pore throat radius with porosity and permeability. The capillary pressure of each phase and equivalent differential pressures can be estimated according to the distribution patterns of each phase in porous media. Finally, a model was built to predict productivity and fluid properties with the \"Differential Pressure Method\". Five tested layers in 3 wells were chosen to verify the accuracy of this model. The results show that the evaluation results are basically consistent with the test results.",
        "keywords": [
            "Differential pressure method",
            "Equivalent differential pressure",
            "Pore-throat radius",
            "Tarim Basin",
            "Tight sandstone"
        ],
        "venue": "Oil and Gas Geology",
        "year": 2013,
        "id": "7GjEhN2M"
    },
    "IQoVTMMg": {
        "authors": [
            {
                "name": "Zhenli Ma",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Yangchun Cheng",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            },
            {
                "name": "Ming Chen",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Jinqing Wei",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Chengrong Li",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            }
        ],
        "title": "Study on the influence of gases on white marks and carbonized tracks generated by partial discharge in transformer oil-paper insulation",
        "abstract": "Partial discharge (PD) in oil-paper insulation of transformer is considered to be a serious fault condition. The movement of excessive charge over pressboard may result in mechanical and chemical damage to material through thermal and electronic action. With the development of PD, gases, white marks and tracks appeared. To research the relationship among the gases white marks and carbonized tracks, a needle-plate electrode configuration was set in laboratory. Pressboards with grooves of varying depths were made to release the gases. And all the pressboards were dissected layer by layer so as to observe carbonized tracks inside the pressboard. Besides, the phenomena of gases, white marks and tracks were recorded by taking photos. The experiment showed that: with the development of PD, carbonized tracks appeared on the pressboards. And as the decomposition of the insulation oil and pressboards, a large amount of gases were generated and overflowed through the pressboard pores, then white marks were formed; Moreover, due to the existence of residual gases, the surface of pressboard was raised where PD happened; As the gases loosed and even broke the pressboards' structure, PD took place more easily. As a result, carbonized tracks grew to be more. \u00a9 2013 IEEE.",
        "keywords": [
            "oil-paper insulation",
            "partial discharge",
            "trackings"
        ],
        "venue": "Proceedings of IEEE International Conference on Solid Dielectrics, ICSD",
        "year": 2013,
        "id": "IQoVTMMg"
    },
    "mojjH7So": {
        "authors": [
            {
                "name": "Wei Wang",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Yang Xue",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Yang-Chun Cheng",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Ming Chen",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Jian-Feng Xu",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Cheng-Rong Li",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            }
        ],
        "title": "Diagnosis of severity degree for power transformer oil-pressboard insulation surface discharge",
        "abstract": "It is very important to determine the severity degree for power transformer oil-pressboard insulation surface discharge. To research the diagnosis method of severity degree for power transformer oil-pressboard insulation surface discharge based on ultra high frequency (UHF) signal and dissolved gases analysis (DGA) in oil, a surface discharge simulation and test equipment and measurement system were set up in laboratory, which consisted of surface discharge model, test tank, UHF sensor, Zhongfen 2000A gas-phase chromatographic instrument, and DST-4 partial discharge detector. Moreover, surface discharge growth from inception to breakdown was simulated, in which test voltage was increased step-by-step, and ultra high frequency signal and dissolved gases in oil were measured in the growth process. Finally, a diagnosis method of severity degree for power transformer oil-pressboard insulation surface discharge was put forward according to the regular pattern of ultra high frequency signal and dissolved gases in oil. The results show that severity degree of surface discharge can be divided into three stages: inception stage, growth stage, and critical stage according to statistics spectrum of the ultra high frequency signal; ultra high frequency signal and dissolved gases in oil both can indicate the oil-pressboard surface discharge severity degree, however, dissolved gases analysis method is not as sensitive as ultra high frequency method; C",
        "keywords": [
            "Diagnosis",
            "Dissolved gases analysis(DGA)",
            "Power transformer",
            "Severity degree",
            "Surface discharge",
            "Ultra high frequency(UHF)"
        ],
        "venue": "Gaodianya Jishu/High Voltage Engineering",
        "year": 2011,
        "id": "mojjH7So"
    },
    "yZr1SEv7": {
        "authors": [
            {
                "name": "Wei Wang",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Bing Zhou",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Jian-Feng Xu",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Xin Wang",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Ming Chen",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            },
            {
                "name": "Cheng-Rong Li",
                "org": "Beijing Key Laboratory of High Voltage and Electromagnetic Compatibility"
            }
        ],
        "title": "Creepage discharge performance of high moisture pressboard in oil-paper insulation system",
        "abstract": "High moisture in pressboard may be a predominant factor causing creepage discharge failure in power transformer. To research the creepage discharge performance of high moisture pressboard, possible high moisture in pressboard of power transformer was analyzed according to Oommen paper-oil moisture equilibrium curves, and a creepage discharge simulation and test setup and measurement system were established, which were consisted of creepage discharge model, test tank, Zhongfen 2000 A gas-phase chromatographic instrument, and DST-4 partial discharge detector. Moreover, a creepage discharge model was constructed by 25 cm-long pressboard between plate electrode and ball electrode. When the moisture of pressboard reached 7% in creepage discharge process, the apparent discharge magnitude and dissolved gases in oil were measured. The results show that moisture of part pressboard may reach to 7% when oil moisture is 30\u00d710",
        "keywords": [
            "Creepage",
            "Dissolved gases",
            "Moisture",
            "Power transformer",
            "Pressboard",
            "White mark"
        ],
        "venue": "Gaodianya Jishu/High Voltage Engineering",
        "year": 2011,
        "id": "yZr1SEv7"
    },
    "gy5DqVg9": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            },
            {
                "name": "Yangchun Cheng",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            },
            {
                "name": "Chun Deng",
                "org": "North China Electric Power Research Institute Co. Ltd"
            },
            {
                "name": "Shaoyu Liu",
                "org": "North China Electric Power Research Institute Co. Ltd"
            },
            {
                "name": "Changjin Diao",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            }
        ],
        "title": "Research on the process of the transformer winding inter-turn discharge caused by corrosive sulphur",
        "abstract": "Corrosive sulphur has been identified to cause unexpected failure in electric power transformer in recent years. In this paper, The winding samples were aged in 25# Kunlun transformer oil with sulphur powder to form sulphur corrosion. Then their partial discharge inception voltage and partial discharge developing process were researched by high voltage experiments. Tens samples were aged for 14, 24 and 30 days in oven of 130 \u00b0C with sulphur concentration of 0.3mg/g. Fourier infrared spectral analysis was done to confirm the cuprous sulfide has deposited on the surface of the insulation paper. Tearing strength of the paper bands of the windings was measured to analyze the influence of the corrosion to the paper. In order to research the influence of the sulphur corrosion to the dielectric characteristic of the windings, the partial discharge inception voltage and the developing process of the partial discharge were measured under step raising high voltage. The results show that the sulphur corrosion reduces the tearing strength and the partial discharge inception voltage so that the corroded transformers have more risk to partial discharge and short circuit failures. The PDs of the windings has a developing process. The average magnitude, maximum magnitude and PD numbers increase with high voltage or time obeyed an exponent rule, but the pattern of the phase distribution point graph of the PDs has almost no change. According to the increasing speed, the developing process has three stages. At the first stage, the PD phenomena were stable for very long time, the PD number and PD magnitude had not obvious increase. At the second stage, the PD number and PD magnitude suddenly increased with exponent rules. At the third stage, there were more and more very big PD pulses. The PDs can be divided into small ones and big ones. These research are valuable for the life evaluation and condition monitoring of large electrical power transformers. \u00a9 2011 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "Annual Report - Conference on Electrical Insulation and Dielectric Phenomena, CEIDP",
        "year": 2011,
        "id": "gy5DqVg9"
    },
    "yyfnWAhX": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            },
            {
                "name": "Yinghui Yan",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            },
            {
                "name": "Yangchun Cheng",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            },
            {
                "name": "Changjin Diao",
                "org": "State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources"
            }
        ],
        "title": "The characteristic of transformer winding inter-turn discharge under sulphur corrosion and thermal ageing",
        "abstract": "In order to study transformer winding inter-turn discharge caused by corrosive sulphur, A series of comparative tests were designed. Firstly, a series of accelerated ageing tests of transformer oil were completed. All the oil samples were processed by dehydration and degasification, then divided into three groups, one group samples were added with insulation paper wrapped-copper electrodes and sulphur. while the other group samples were added with electrodes but no sulphur, then aged under 130\u00b0C for 14, 24 and 30 days respectively. Next a number of experiments were taken to research the discharge process according to IEC standard methods. The results indicated that the partial discharge inception voltage by corrosive sulfide dropped very significantly compared with the electrodes without sulphur, and it reduced with the ageing time, but the breakdown voltage variation was much smaller and during the whole developing process, the discharge continuing time increased from 14 days to 24 days, then decreased for 24 days to 30 days. At the same time, the insulation papers are taken to measure the tear resistance, which shows the same trend with the discharge continuing time, Those results are valuable for evaluating the transformer condition order of severity corroded by corrosive sulphur and helpful to evaluating the large transformer life and monitoring the condition of large electrical power transformers. \u00a9 2012 IEEE.",
        "keywords": [
            "Corrosive Sulphur",
            "Thermal Ageing",
            "Transformer Winding Inter-turn"
        ],
        "venue": "Proceedings - 2012 International Conference on Intelligent Systems Design and Engineering Applications, ISDEA 2012",
        "year": 2012,
        "id": "yyfnWAhX"
    },
    "wcn6E64N": {
        "authors": [
            {
                "name": "Yinghui Yan",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Ming Chen",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Yangchun Cheng",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Jianliang Kong",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Hongxin Ji",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            },
            {
                "name": "Anqi Song",
                "org": "Beijing Key Laboratory of High Voltage and EMC"
            }
        ],
        "title": "A nanosecond high voltage impluse protector for small signal measurement device",
        "abstract": "In high voltage partial discharge experiments, the partial discharge measurement device is in the risk of fast transient high voltage because of insulation sample breakdows. An protector is designed based on the gas discharge tube and switching diode to protect the measurement devices. The frequency spectrum of the protector was measured by square signal and sine wave signal. Its protection capability were proved by nanosecond high voltage impulse, high voltage lightning impulse, and oil insulation breakdown trans instantaneous high voltage. The test results showed that the protector has wide frequency beyond 80MHz. And the outage voltage fo the protector can be limited to 2V even if its input come up to 30kV and less than 5ns. \u00a9 2012 IEEE.",
        "keywords": [
            "Discharge Tube",
            "High Voltage",
            "Input Protector",
            "Switching Diode"
        ],
        "venue": "Proceedings - 2012 International Conference on Intelligent Systems Design and Engineering Applications, ISDEA 2012",
        "year": 2012,
        "id": "wcn6E64N"
    },
    "TAk0tAzM": {
        "id": "TAk0tAzM",
        "title": "Supporting Evolution in a Multi-Agent Cooperative Design Environment",
        "abstract": "",
        "keywords": [
            "evolutionary computing"
        ],
        "authors": [
            {
                "name": "hong liu",
                "org": ""
            },
            {
                "name": "ming xi tang",
                "org": ""
            },
            {
                "name": "john h frazer",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "zqgKFyhN": {
        "id": "zqgKFyhN",
        "title": "A knowledge based collaborative design environment",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hong liu",
                "org": ""
            },
            {
                "name": "ming xi tang",
                "org": ""
            },
            {
                "name": "john h frazer",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "m4nbThBl": {
        "id": "m4nbThBl",
        "title": "Evolutionary design in a multi-agent design environment",
        "abstract": "This paper presents a novel evolutionary design approach in a multi-agent design environment. Multi-agent system architecture offers a promising framework for dynamically managing cooperative agents in a distributed environment while the tree structure based generic algorithm provides a foundation for supporting evolutionary and innovative design abilities. Design is a complex knowledge discovery process. Creative design is a human trait that is not easily converted into a computational tool. Rather than to implement the innovative design by computers, this environment is used to stimulate the imagination of designers and extend their thinking space. It wants to explore a feasible and useful evolutionary approach in a distributed environment that will give the designers concrete help for the creative designs. This approach is illustrated by a mobile phone design example, which used binary algebraic expression tree to form sketch shapes and a feature based product tree to produce component combination choices. Because evolution is guided by human selectors, the evolutionary algorithm is not complex. It shows that approach is able to generate some creative solutions, demonstrating the power of explorative evolution.",
        "keywords": [
            "multi-agent design environment",
            "evolutionary computing",
            "novel evolutionary design approach",
            "creative design",
            "binary algebraic expression tree",
            "evolutionary algorithm",
            "creative solution",
            "innovative design",
            "evolutionary design",
            "innovative design ability",
            "computer-aided design",
            "useful evolutionary approach",
            "generic algorithm",
            "mobile phone design example",
            "multi-agent system"
        ],
        "authors": [
            {
                "name": "hong liu",
                "org": ""
            },
            {
                "name": "ming xi tang",
                "org": ""
            },
            {
                "name": "john h frazer",
                "org": ""
            }
        ],
        "venue": "Appl. Soft Comput.",
        "year": 2006
    },
    "Uq18JkpJ": {
        "id": "Uq18JkpJ",
        "title": "A Kind of Evolutionary Design Approach in Distributed Environment",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hong liu",
                "org": ""
            },
            {
                "name": "ming xi tang",
                "org": ""
            },
            {
                "name": "john h frazer",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "oQwWf7HI": {
        "id": "oQwWf7HI",
        "title": "Systems and methods for providing perpendicular magnetic writers having gradient magnetic moment side shields",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "dehua han",
                "org": ""
            },
            {
                "name": "ming sun",
                "org": ""
            },
            {
                "name": "yugang wang",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "tTnj8tsG": {
        "id": "tTnj8tsG",
        "title": "Conformal high moment side shield seed layer for perpendicular magnetic recording writer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "dehua han",
                "org": ""
            },
            {
                "name": "yugang wang",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "FYBg36Vg": {
        "id": "FYBg36Vg",
        "title": "Method and system for providing an antiferromagnetically coupled writer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ming sun",
                "org": ""
            },
            {
                "name": "dehua han",
                "org": ""
            },
            {
                "name": "jose a medina",
                "org": ""
            },
            {
                "name": "ming jiang",
                "org": ""
            },
            {
                "name": "ying hong",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "jian shen x",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "v7HlH6ar": {
        "id": "v7HlH6ar",
        "title": "METHOD FOR PROVIDING A MAGNETIC RECORDING TRANSDUCER INCLUDING A WRAPAROUND SHIELD AND A RECTANGULAR POLE",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinqiu zhang",
                "org": ""
            },
            {
                "name": "xiaoyu yang",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "ming jiang",
                "org": ""
            },
            {
                "name": "tsung yuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "UbamhO8Y": {
        "id": "UbamhO8Y",
        "title": "Magnetic recording head having a dual sidewall angle",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yunfei li",
                "org": ""
            },
            {
                "name": "lijie guan",
                "org": ""
            },
            {
                "name": "ying hong",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "jinqiu zhang",
                "org": ""
            },
            {
                "name": "yugang wang",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "GVZQW52D": {
        "id": "GVZQW52D",
        "title": "Effect of reactive gas (oxygen/chlorine/fluorine) etching on the magnetic flux of a high moment write pole material",
        "abstract": "",
        "keywords": [
            "plasma processing",
            "x ray diffraction",
            "magnetic susceptibility",
            "magnetic moment",
            "transmission electron microscopy",
            "iron",
            "magnetic properties",
            "plasma etching",
            "cross section"
        ],
        "authors": [
            {
                "name": "jinqiu zhang",
                "org": "western digital"
            },
            {
                "name": "feng liu",
                "org": "western digital"
            },
            {
                "name": "lifan chen",
                "org": "western digital"
            },
            {
                "name": "l miloslavsky",
                "org": "western digital"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2010
    },
    "0860QOmQ": {
        "id": "0860QOmQ",
        "title": "Modeling magnetic column intermediate layer of perpendicular magnetic recording",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhanjie li",
                "org": ""
            },
            {
                "name": "daniel z bai",
                "org": ""
            },
            {
                "name": "shaoping li",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "sining mao",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2012
    },
    "NfayUvco": {
        "id": "NfayUvco",
        "title": "Characteristics of reverse overwrite process in shingled recording scheme at ultra-high track density",
        "abstract": "Research highlights \u25ba This paper discusses the most advanced recording scheme, e.g., shingled recording process, for next generation magnetic data storage devices. \u25ba The paper shows that the write-ability of magnetic recording is sufficient in the shingled recording scheme even when the areal density is beyond 1.0 Tb/in 2 . \u25ba Our results also shows that the writer\u2019s edge write-ability is essential for reducing noise during the write process in shingled recording scheme. \u25ba The paper also demonstrates that a multiple and sequential write process ensures the normal erasure-ability in shingled recording scheme. \u25ba Our results also indicate that the noise nature in the write process still could be attributed to the hard-easy transition and imprint effect.",
        "keywords": [
            "track edge noise",
            "perpendicular recording (pmr)",
            "reverse overwrite",
            "shingled recording"
        ],
        "authors": [
            {
                "name": "Shaoping Li",
                "org": ""
            },
            {
                "name": "Hector Mendez",
                "org": "Western Digital Inc. 1250 Reliance Way, Fremont, CA 94539, USA"
            },
            {
                "name": "Dave Terrill",
                "org": "Western Digital Inc. 1250 Reliance Way, Fremont, CA 94539, USA"
            },
            {
                "name": "Feng Liu",
                "org": "Western Digital Inc. 1250 Reliance Way, Fremont, CA 94539, USA"
            },
            {
                "name": "Daniel Bai",
                "org": "Western Digital Inc. 1250 Reliance Way, Fremont, CA 94539, USA"
            },
            {
                "name": "Sining Mao",
                "org": "Western Digital Inc. 1250 Reliance Way, Fremont, CA 94539, USA"
            }
        ],
        "venue": "Journal of Magnetism and Magnetic Materials",
        "year": 2012
    },
    "4kw7NElK": {
        "id": "4kw7NElK",
        "title": "Magnetic recording writer having a main pole with multiple flare angles",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "zhanjie li",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "2smdbkWY": {
        "id": "2smdbkWY",
        "title": "Magnetic recording head with nano scale pole tip bulge",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "yugang wang",
                "org": ""
            },
            {
                "name": "sining mao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "neWb3isx": {
        "id": "neWb3isx",
        "title": "Effect of track asymmetry and curvature on shingle writing scheme",
        "abstract": "",
        "keywords": [
            "signal to noise ratio",
            "error rate"
        ],
        "authors": [
            {
                "name": "feng liu",
                "org": "western digital"
            },
            {
                "name": "shaoping li",
                "org": "western digital"
            },
            {
                "name": "daniel bai",
                "org": "western digital"
            },
            {
                "name": "h mendez",
                "org": "western digital"
            },
            {
                "name": "tao pan",
                "org": "western digital"
            },
            {
                "name": "dehua han",
                "org": "western digital"
            },
            {
                "name": "sining mao",
                "org": "western digital"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2011
    },
    "mWrKuZ02": {
        "id": "mWrKuZ02",
        "title": "Method for providing a side shield for a magnetic recording transducer using an air bridge",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinqiu zhang",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "shaoping li",
                "org": ""
            },
            {
                "name": "ming sun",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "Kd97dovt": {
        "id": "Kd97dovt",
        "title": "Degaussing PMR Writer Poles: A Micromagnetic Modeling Study",
        "abstract": "",
        "keywords": [
            "magnetization",
            "magnetic hysteresis",
            "remanence",
            "micromagnetics",
            "hysteresis loop",
            "indexing terms",
            "writing",
            "magnetisation"
        ],
        "authors": [
            {
                "name": "daniel z bai",
                "org": "western digital"
            },
            {
                "name": "zhanjie li",
                "org": "western digital"
            },
            {
                "name": "tao pan",
                "org": "western digital"
            },
            {
                "name": "peng luo",
                "org": "western digital"
            },
            {
                "name": "shaoping li",
                "org": "western digital"
            },
            {
                "name": "feng liu",
                "org": "western digital"
            },
            {
                "name": "heyun lin",
                "org": "western digital"
            },
            {
                "name": "sining mao",
                "org": "western digital"
            }
        ],
        "venue": "IEEE Transactions on Magnetics",
        "year": 2011
    },
    "Hct29g8s": {
        "id": "Hct29g8s",
        "title": "Method for providing side shields having non-conformal regions for a magnetic recording transducer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "yugang wang",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "hongzhou jiang",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            },
            {
                "name": "shaoping li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "h1sqQfBy": {
        "id": "h1sqQfBy",
        "title": "Method for providing a wraparound shield for a magnetic recording transducer using a damascene process",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinqiu zhang",
                "org": ""
            },
            {
                "name": "ying hong",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "El2nCSTj": {
        "id": "El2nCSTj",
        "title": "Perpendicular magnetic recording writer pole with leading and trailing bevel side wall angles at air bearing surface",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "yugang wang",
                "org": ""
            },
            {
                "name": "jinqiu zhang",
                "org": ""
            },
            {
                "name": "ying hong",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "pC5SVWph": {
        "id": "pC5SVWph",
        "title": "Magnetic writer having a low aspect ratio two layer coil",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "zhanjie li",
                "org": ""
            },
            {
                "name": "zhigang bai",
                "org": ""
            },
            {
                "name": "ut tran",
                "org": ""
            },
            {
                "name": "kevin k lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "wonPE4VT": {
        "id": "wonPE4VT",
        "title": "Write Field Dynamics in the Presence of Antiferromagnetic Coupling of Writer Pole",
        "abstract": "A micromagnetic simulation is conducted to study the write field dynamics in the presence of antiferromagnetic exchange coupling (AFC) of writer pole for a perpendicular magnetic recording (PMR) writer head. It is found that, depending on the actual configuration of the AFC coupling in the yoke and the pole tip, there could be an intermediate transient state near zero write field during the magnetization reversal, compared to the normal writer design without AFC coupling. This transient state may cause recording performance degradation. We further investigated the AFC coupling effect on the remanent field in the degauss process. For different performance aspects, i.e., field dynamics, maximum field, and remanent field, the AFC in the yoke and in the pole tip plays different roles.",
        "keywords": [
            "antiferromagnetism",
            "exchange interactions (electron)",
            "magnetic heads",
            "magnetisation reversal",
            "micromagnetics",
            "perpendicular magnetic recording",
            "afc coupling",
            "antiferromagnetic exchange coupling",
            "magnetization reversal",
            "micromagnetic simulation",
            "transient state",
            "write field dynamics",
            "writer head",
            "writer pole",
            "antiferromagnetic exchange coupling (afc) coupling",
            "micromagnetic modeling",
            "perpendicular magnetic recording (pmr) writer",
            "frequency control",
            "magnetic shielding",
            "magnetization",
            "couplings"
        ],
        "authors": [
            {
                "name": "zhanjie li",
                "org": "western digital"
            },
            {
                "name": "daniel z bai",
                "org": "western digital"
            },
            {
                "name": "tao pan",
                "org": "western digital"
            },
            {
                "name": "dehua han",
                "org": "western digital"
            },
            {
                "name": "feng liu",
                "org": "western digital"
            },
            {
                "name": "shaoping li",
                "org": "western digital"
            },
            {
                "name": "song yuan",
                "org": "western digital"
            }
        ],
        "venue": "Magnetics, IEEE Transactions",
        "year": 2013
    },
    "1xgvuali": {
        "id": "1xgvuali",
        "title": "Commercial TMR heads for hard disk drives: characterization and extendibility at 300 gbit/in/sup 2/",
        "abstract": "Tunneling magnetoresistive (TMR) reading heads at an areal density of 80-100 Gbit/in/sup 2/ in a longitudinal magnetic recording mode have for the first time been commercialized for both laptop and desktop Seagate hard disk drive products. The first generation TMR products utilized a bottom TMR stack and an abutted hard bias design. These TMR heads have demonstrated three times the amplitude of comparable giant magnetoresistive (GMR) devices, resulting in a 0.6 decade bit error rate gain over GMR. This has enabled high component and drive yields. Due to the improved thermal dissipation of current-perpendicular-to-plane geometry, TMR runs cooler and has better lifetime performance, and has demonstrated the similar electrical static discharge robustness as GMR. TMR has demonstrated equivalent or better process and wafer yields compared to GMR. The TMR heads is proven to be a mature and capable reader technology. Using the same TMR head design in conjunction with perpendicular recording, 274 Gbit/in/sup 2/ has been demonstrated. Advanced design can reach 311 Gbit/in/sup 2/.",
        "keywords": [
            "Hard disks",
            "Tunneling magnetoresistance",
            "Giant magnetoresistance",
            "Magnetic heads",
            "Magnetic tunneling",
            "Magnetic recording",
            "Commercialization",
            "Portable computers",
            "Bit error rate",
            "Geometry"
        ],
        "authors": [
            {
                "name": "Sining Mao",
                "org": " and D.J. Lennon"
            },
            {
                "name": "Yonghua Chen",
                "org": "Computer Science Department, University of Illinois"
            },
            {
                "name": "Feng Liu",
                "org": " L. Piilonen"
            },
            {
                "name": "Xingfu Chen",
                "org": "Wright State Univ., Dayton, OH"
            },
            {
                "name": "Bin Xu",
                "org": ""
            },
            {
                "name": "Puling Lu",
                "org": "IBM Research Division, T. J. Watson Research Center, Yorktown Heights, NY"
            },
            {
                "name": "M. Patwari",
                "org": ""
            },
            {
                "name": "Haiwen Xi",
                "org": "Department of Physics and Astronomy and National Superconducting Cyclotron; Laboratory"
            },
            {
                "name": "Clif Chang",
                "org": "Department of Electrical and Computer Engineering, University of California, Santa Barbara, CA"
            },
            {
                "name": "B. Miller",
                "org": ""
            },
            {
                "name": "D. Menard",
                "org": ""
            },
            {
                "name": "B. Pant",
                "org": ""
            },
            {
                "name": "J. Loven",
                "org": ""
            },
            {
                "name": "K. Duxstad",
                "org": ""
            },
            {
                "name": "Shaoping Li",
                "org": ""
            },
            {
                "name": "Zhengyong Zhang",
                "org": ""
            },
            {
                "name": "A. Johnston",
                "org": ""
            },
            {
                "name": "R. Lamberton",
                "org": ""
            },
            {
                "name": "M. Gubbins",
                "org": ""
            },
            {
                "name": "T. McLaughlin",
                "org": ""
            },
            {
                "name": "J. Gadbois",
                "org": ""
            },
            {
                "name": "Juren Ding",
                "org": ""
            },
            {
                "name": "B. Cross",
                "org": ""
            },
            {
                "name": "Song Xue",
                "org": ""
            },
            {
                "name": "P. Ryan",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Magnetics",
        "year": 2006
    },
    "Y3vnXlh8": {
        "id": "Y3vnXlh8",
        "title": "Current perpendicular-to-plane read sensor with back shield",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "shaoping li",
                "org": ""
            },
            {
                "name": "laurence l chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "4X2mX4mc": {
        "id": "4X2mX4mc",
        "title": "Method for fabricating a magnetic writer having half-side shields",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinqiu zhang",
                "org": ""
            },
            {
                "name": "lienchang wang",
                "org": ""
            },
            {
                "name": "xiaoyu yang",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "ming jiang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "SI4oC0w7": {
        "id": "SI4oC0w7",
        "title": "Effects of pinning defects on current-perpendicular-to-plane magnetic recording heads",
        "abstract": "",
        "keywords": [
            "time domain"
        ],
        "authors": [
            {
                "name": "laurence chen",
                "org": "western digital"
            },
            {
                "name": "feng liu",
                "org": "western digital"
            },
            {
                "name": "kroum s stoev",
                "org": "western digital"
            },
            {
                "name": "shaoping li",
                "org": "western digital"
            },
            {
                "name": "michael ho",
                "org": "western digital"
            },
            {
                "name": "sining mao",
                "org": "western digital"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2009
    },
    "ZvD5jGKe": {
        "id": "ZvD5jGKe",
        "title": "Impact of fluorine based reactive chemistry on structure and properties of high moment magnetic material",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoyu yang",
                "org": ""
            },
            {
                "name": "lifan chen",
                "org": ""
            },
            {
                "name": "hongmei han",
                "org": ""
            },
            {
                "name": "lianfeng fu",
                "org": ""
            },
            {
                "name": "ming sun",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "jinqiu zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2014
    },
    "kg8RH8H2": {
        "id": "kg8RH8H2",
        "title": "Reverse Overwrite Process in Shingled Recording Process at Ultrahigh Track Density",
        "abstract": "",
        "keywords": [
            "signal to noise ratio",
            "geometry",
            "magnetic materials",
            "writing",
            "saturation magnetization",
            "bit error rate",
            "areal density"
        ],
        "authors": [
            {
                "name": "Shaoping Li",
                "org": ""
            },
            {
                "name": "Hector Mendez",
                "org": ""
            },
            {
                "name": "Dave Terrill",
                "org": ""
            },
            {
                "name": "Feng Liu",
                "org": ""
            },
            {
                "name": "Zhen Jin",
                "org": ""
            },
            {
                "name": "Yimin Guo",
                "org": ""
            },
            {
                "name": "Lieping Zhong",
                "org": ""
            },
            {
                "name": "Adam Torabi",
                "org": ""
            },
            {
                "name": "Sining Mao",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Magnetics",
        "year": 2010
    },
    "tOlRMelz": {
        "id": "tOlRMelz",
        "title": "Write head with variable side shield gaps",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shaoping li",
                "org": ""
            },
            {
                "name": "ge yi",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "AfRNB5HX": {
        "id": "AfRNB5HX",
        "title": "Electrical low frequency random telegraph noise in magnetic tunnel junctions",
        "abstract": "",
        "keywords": [
            "magnetic field",
            "spin polarization",
            "giant magnetoresistance",
            "low frequency",
            "magnetic tunnel junction",
            "frequency domain",
            "activation energy"
        ],
        "authors": [
            {
                "name": "feng liu",
                "org": "western digital"
            },
            {
                "name": "yunfei ding",
                "org": "western digital"
            },
            {
                "name": "ravindra kemshetti",
                "org": "western digital"
            },
            {
                "name": "k t r davies",
                "org": "western digital"
            },
            {
                "name": "paul rana",
                "org": "western digital"
            },
            {
                "name": "sining mao",
                "org": "western digital"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2009
    },
    "h5otiaMJ": {
        "id": "h5otiaMJ",
        "title": "Characteristics of magnetic force microscopy magnetics on high moment perpendicular magnetic recording writers with high coercivity probes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "shaoping li",
                "org": ""
            },
            {
                "name": "daniel bai",
                "org": ""
            },
            {
                "name": "jimmy wang",
                "org": ""
            },
            {
                "name": "zhanjie li",
                "org": ""
            },
            {
                "name": "dehua han",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            },
            {
                "name": "sining mao",
                "org": ""
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2012
    },
    "aQ0ubvWO": {
        "id": "aQ0ubvWO",
        "title": "Magnetic recording sensor with sputtered antiferromagnetic coupling trilayer between plated ferromagnetic shields",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "dehua han",
                "org": ""
            },
            {
                "name": "ming sun",
                "org": ""
            },
            {
                "name": "yimin guo",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2010
    },
    "eUeJAZGy": {
        "id": "eUeJAZGy",
        "title": "Method and system for providing a magnetic transducer having a high moment bilayer magnetic seed layer for a trailing shield",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chengtao r yu",
                "org": ""
            },
            {
                "name": "dehua han",
                "org": ""
            },
            {
                "name": "ying hong",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "bo zhang",
                "org": ""
            },
            {
                "name": "tao pan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "5jSiMGIL": {
        "id": "5jSiMGIL",
        "title": "Quantitative analysis of transition curvature by magnetic force microscopy",
        "abstract": "",
        "keywords": [
            "quantitative analysis",
            "magnetic force microscopy"
        ],
        "authors": [
            {
                "name": "feng liu",
                "org": "seagate technology"
            },
            {
                "name": "shaoping li",
                "org": "seagate technology"
            },
            {
                "name": "yan liu",
                "org": "seagate technology"
            },
            {
                "name": "george m gray",
                "org": "seagate technology"
            },
            {
                "name": "allan e schultz",
                "org": "seagate technology"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2002
    },
    "6Dz1xfZ8": {
        "authors": [
            {
                "name": "Qian Chen",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Jiqiang Tang",
                "org": "National Computer Network Emergency Response Technical Team"
            },
            {
                "name": "David Tung Chong Wong",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Xiaoming Peng",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Youguang Zhang",
                "org": "Beihang University"
            }
        ],
        "title": "Directional cooperative MAC protocol design and performance analysis for IEEE 802.11ad WLANs",
        "abstract": "In this paper, we consider the directional multigigabit (DMG) transmission problem in IEEE 802.11ad wireless local area networks (WLANs) and design a random-access-based medium access control (MAC) layer protocol incorporated with a directional antenna and cooperative communication techniques. A directional cooperative MAC protocol, namely, D-CoopMAC, is proposed to coordinate the uplink channel access among DMG stations (STAs) that operate in an IEEE 802.11ad WLAN. Using a 3-D Markov chain model with consideration of the directional hidden terminal problem, we develop a framework to analyze the performance of the D-CoopMAC protocol and derive a closed-form expression of saturated system throughput. Performance evaluations validate the accuracy of the theoretical analysis and show that the performance of D-CoopMAC varies with the number of DMG STAs or beam sectors. In addition, the D-CoopMAC protocol can significantly improve system performance, as compared with the traditional IEEE 802.11ad MAC protocol. \u00a9 1967-2012 IEEE.",
        "keywords": [
            "Cooperative communication",
            "directional antenna",
            "IEEE 802.11ad",
            "medium access control (MAC)",
            "performance analysis",
            "saturated system throughput"
        ],
        "venue": "IEEE Transactions on Vehicular Technology",
        "year": 2013,
        "id": "6Dz1xfZ8"
    },
    "Sru9sEYl": {
        "authors": [
            {
                "name": "Qian Chen",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Xiaoming Peng",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Juan Yang",
                "org": "National Mobile Communications Research Laboratory"
            },
            {
                "name": "Francois Chin",
                "org": "Institute for Infocomm Research"
            }
        ],
        "title": "Spatial reuse strategy in mmWave WPANs with directional antennas",
        "abstract": "In this paper, we propose a spatial reuse strategy for millimeter-wave (mmWave) wireless personal area networks (WPANs) with directional antennas. By this strategy, two or more transmissions can be appropriately scheduled for spatial sharing based on the beamforming (BF) information. Moreover, we analyze the performance of this strategy with consideration of the difference between idealistic and realistic directional antennas. Simulation results show that the strategy efficiency is related to antenna types, configurations and network topologies, and that the spatial multiplexing gain can be increased accordingly. \u00a9 2012 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "GLOBECOM - IEEE Global Telecommunications Conference",
        "year": 2012,
        "id": "Sru9sEYl"
    },
    "7jLiWFI6": {
        "authors": [
            {
                "name": "Ran Cai",
                "org": "Beijing University of Posts and Telecommunications"
            },
            {
                "name": "Qian Chen",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Xiaoming Peng",
                "org": "Institute for Infocomm Research"
            },
            {
                "name": "Danpu Liu",
                "org": "Beijing University of Posts and Telecommunications"
            }
        ],
        "title": "Spatial sharing algorithm in mmWave WPANs with interference sense beamforming mechanism",
        "abstract": "In this paper, we address the spatial sharing problem in millimeter-wave (mmWave) wireless personal access networks (WPANs). In order to establish conflict graph and study interference relationship among devices, we incorporate the interference measurement with the traditional beamforming (BF) training and propose an interference sense beamforming (ISBF) mechanism. Based on physical interference model, we derive the spatial sharing (SPSH) conditions for concurrent transmissions and develop a new algorithm, namely, maximum coexistence possibility (MCP), to improve the SPSH gain. Performance evaluations show that the MCP algorithm dramatically improves the SPSH gain, and that the new algorithm outperforms the existing blind selection algorithm by 15%-31%. \u00a9 2013 IEEE.",
        "keywords": [
            "Interference sense beamforming",
            "MillimeterWave WPANs",
            "Spatial sharing algorithm"
        ],
        "venue": "Proceedings - IEEE Military Communications Conference MILCOM",
        "year": 2013,
        "id": "7jLiWFI6"
    },
    "KOfKctcM": {
        "authors": [
            {
                "name": "Ran Cai",
                "org": "School of Information and Communication, Beijing University of Posts and Telecommunications"
            },
            {
                "name": "Danpu Liu",
                "org": "School of Information and Communication, Beijing University of Posts and Telecommunications"
            },
            {
                "name": "Qian Chen",
                "org": "Institute for Infocomm Research, Agency for Science,Technology and Research"
            },
            {
                "name": "Xiaoming Peng",
                "org": "Institute for Infocomm Research, Agency for Science,Technology and Research"
            }
        ],
        "title": "Optimal SINR-based scheduling in mmWave WPANs with power control and rate adaption",
        "abstract": "Spatial sharing is one of the most important merits in 60 GHz millimeter wave (mmWave) wireless personal area networks (WPANs). In this paper, we address the optimal scheduling problem under physical interference model with power control and rate adaption to exploit spatial sharing in mmWave WPANs. The optimization problem is formulated as the minimum length scheduling problem with the constraint of the minimum traffic demand. To obtain the optimal solution with low computational complexity, column generation (CG) algorithm is employed to derive the optimal schedule. Simulation results demonstrate that the scheduled length for all transmission links can be significantly reduced by using rate adaption and power control schemes, and be further reduced by configuring directional antennas at both transmitter and receiver sides.",
        "keywords": [
            ""
        ],
        "venue": "IEEE Vehicular Technology Conference",
        "year": 2015,
        "id": "KOfKctcM"
    },
    "aB6MV2Rt": {
        "authors": [
            {
                "name": "Q. Zhang",
                "org": "Stat. Key Lab. Polymer Phys./Chem."
            },
            {
                "name": "Z. Mo",
                "org": "Stat. Key Lab. Polymer Phys./Chem."
            },
            {
                "name": "H. Zhang",
                "org": "Stat. Key Lab. Polymer Phys./Chem."
            },
            {
                "name": "S. Liu",
                "org": "Stat. Key Lab. Polymer Phys./Chem."
            },
            {
                "name": "S.Z.D. Cheng",
                "org": "Stat. Key Lab. Polymer Phys./Chem."
            }
        ],
        "title": "Crystal transitions of Nylon 11 under drawing and annealing",
        "abstract": "The crystal transitions of Nylon 11 annealed and drawn at different temperatures (T",
        "keywords": [
            "Crystal transition",
            "Nylon 11",
            "WAXD"
        ],
        "venue": "Polymer",
        "year": 2001,
        "id": "aB6MV2Rt"
    },
    "orMhlWX0": {
        "id": "orMhlWX0",
        "title": "The clinical application of Mitral valve replacement",
        "abstract": "Objective:To summarize the experiences of five cases undergone the mitral valve replacement,and discuss the perioperative management and surgical methods.Method:The clinical data of 5 patients with rheumatic mitral valve disease undergone mitral valve replacement from April 2008 to April 2009 were analyzed retrospectively.Results: After surgery,the cardiac function of patients were raised to grade \u2160,no perioperative death and serious complications.Conclusions: Mitral valve replacement is an effective treatment of rheumatic mitral valve disease.",
        "keywords": [
            "replacement",
            "rheumatic heart disease",
            "mitral valve disease"
        ],
        "authors": [
            {
                "name": "LONG Yuan-bin",
                "org": "The Central People\u2019s Hospital of Ji\u2032an,Ji\u2032an ,China"
            },
            {
                "name": "CAI Qi-gui",
                "org": "The Central People\u2019s Hospital of Ji\u2032an,Ji\u2032an ,China"
            },
            {
                "name": "LI Hong",
                "org": "The Central People\u2019s Hospital of Ji\u2032an,Ji\u2032an ,China"
            },
            {
                "name": "LIU Dong",
                "org": "The Central People\u2019s Hospital of Ji\u2032an,Ji\u2032an ,China"
            },
            {
                "name": "LI Lin",
                "org": "The Central People\u2019s Hospital of Ji\u2032an,Ji\u2032an ,China"
            },
            {
                "name": "KANG Mei-he",
                "org": "The Central People\u2019s Hospital of Ji\u2032an,Ji\u2032an ,China"
            }
        ],
        "venue": "Journal of Jinggangshan University",
        "year": 2009
    },
    "IIALLfWt": {
        "id": "IIALLfWt",
        "title": "Perioperative nursing of ventricular septal defect",
        "abstract": "Objective: To discuss the perioperative nursing of ventricular septal defect.Methods:23 patients with ventricular septal defect received the open heart surgery Under Extracorporeal Circulation were given strengthened perioperative nursing.Results:After the surgery,no case died,all patients' heart murmurs disappeared or became faint,2 case of atelectasis,3 cases of pulmonary infection,one case of intracardiac residual shunt.Conclusion: Strengthening perioperative nursing could improve the success rate of operation,reduce the rate of mortality and complications.",
        "keywords": [
            "ventricular septal defect",
            "perioperative nursing"
        ],
        "authors": [
            {
                "name": "LI Hong",
                "org": "The People's Centre Hospital of Ji'an,Ji'an ,China"
            }
        ],
        "venue": "Journal of Jinggangshan Medical College",
        "year": 2008
    },
    "OlboOCff": {
        "id": "OlboOCff",
        "title": "The repair of ventricular septal defect in children under extracorporeal circulation(A Report of 19 cases)",
        "abstract": "Objective: To summarize the experience of the repair of ventricular septal defect(VSD) in children under extracorporeal circulation.Method:19 children with ventricular septal defect were undergone VSD repair under extracorporeal circulation,and 3 cases associated with open foramen ovale were repaired simultaneously.Results:After operation,there was 1 case appeared residual fistula but without clinical symptoms,1 case occurred acute right heart failure,and 2 cases appeared pulmonary infection.All of them were be controlled after effective treatments.The patients were followed up from 1 month to 8 months,and all of they gained good recovery.Conclusion: Repaire of VSD under extracorporeal circulation is one of the most effective treatment methods in children with VSD.",
        "keywords": [
            "ventricular septal defect",
            "repair of vetricular septal defect",
            "extracorporeal circulation",
            "children"
        ],
        "authors": [
            {
                "name": "CAI Qi-gui",
                "org": "Department of Cardiothoracic,The Central People's Hospital of Ji'an,Ji'an ,China"
            },
            {
                "name": "LI Hong",
                "org": "Department of Cardiothoracic,The Central People's Hospital of Ji'an,Ji'an ,China"
            },
            {
                "name": "KANG Mei-he",
                "org": "Department of Cardiothoracic,The Central People's Hospital of Ji'an,Ji'an ,China"
            },
            {
                "name": "LI Xiao-fei",
                "org": "Department of Operation room,The Central People's Hospital of Ji'an,Ji'an ,China"
            }
        ],
        "venue": "Journal of Jinggangshan University",
        "year": 2009
    },
    "RfYnY5Lk": {
        "id": "RfYnY5Lk",
        "title": "Design and Simulation of the TEC Temperature-Controled Circuit",
        "authors": [
            {
                "name": "ZHOU Shuai",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "CUI Yi-ping",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            }
        ],
        "venue": "chinese journal of electron devices",
        "keywords": [
            "simulation of software Pspice",
            "temperature-controled circuit",
            "laser"
        ],
        "year": 2008
    },
    "lxirWDwD": {
        "id": "lxirWDwD",
        "title": "Preparation and Characterization of Novel PU Nonlinear Optical Nano-hybrid Material",
        "authors": [
            {
                "name": "Zhong Aimin",
                "org": "Department of Applide Chemistry Yangzhou College of Industrial Technology,Jiangsu Yangzhou"
            },
            {
                "name": "Zhou Yuming"
            },
            {
                "name": "Cui Yiping",
                "org": "College of Electronic Science and Engineering of Southeast University,Jiangsu Nanjing "
            },
            {
                "name": "Zhang Tong",
                "org": "College of Electronic Science and Engineering of Southeast University,Jiangsu Nanjing "
            }
        ],
        "venue": "chemical industry times",
        "keywords": [
            "nonlinear optical polyurethane composite material disperse red 19 silicon dioxide"
        ],
        "year": 2006
    },
    "kFjYOCYN": {
        "id": "kFjYOCYN",
        "title": "Acceleration Sensor Based on Flexible Waveguide Coupling with Integrated Optical Microring Resonator",
        "abstract": "An acceleration sensor based on flexible waveguide coupling with integrated optical microring resonator is demonstrated in this paper.Deformation of a flexible polymer waveguide caused by acceleration results in change of the distance between itself and the waveguide of the microring resonator,therefore the coupling rate is altered.This variation makes the output characteristics of the microring resonator be altered correspondingly.By detecting the output optical intensity of spectrum of the microring resonator under the condition of optimum resonance,the acceleration is measured effectively.The design of this novel structure is given and the measuring principle together with influence factor of sensitivity are derived and discussed.",
        "keywords": [
            "microring waveguide",
            "acceleration sensing",
            "flexible optical waveguide",
            "optical resonantor",
            "coupling rate"
        ],
        "authors": [
            {
                "name": "Qi Zhen-heng",
                "org": "College of Mechatronics Engineering and Automation,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHANG Xiao-yang",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "HU De-wen",
                "org": "College of Mechatronics Engineering and Automation,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Chinese Journal of Sensors and Actuators",
        "year": 2009
    },
    "uaTgTLci": {
        "id": "uaTgTLci",
        "title": "The study of ternary-copolymer of fluorinated polyimides",
        "authors": [
            {
                "name": "LIU Rong",
                "org": " School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHOU Yu-ming",
                "org": " School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "HE Man",
                "org": " School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "DAI Jia",
                "org": " School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "CUI Yi-ping",
                "org": " School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": " School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            }
        ],
        "venue": "journal of functional materials",
        "keywords": [
            "thermal stability",
            "transmission loss",
            "mechanic properties",
            "copolymerization",
            "fluorinated polyimides"
        ],
        "year": 2008
    },
    "CdChdXVS": {
        "id": "CdChdXVS",
        "title": "Design Method of Modification in Cross Section for Curved Optical Waveguides",
        "authors": [
            {
                "name": "WANG Qiao",
                "org": "The 55th Research Institute of China Electronic Technology Group Corporation,Nanjing,,CHN"
            },
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing,,CHN"
            }
        ],
        "venue": "optoelectronic technology",
        "keywords": [
            "optical waveguides",
            "conformal transformation",
            "integrated optics",
            "bend loss",
            "modification in cross section"
        ],
        "year": 2007
    },
    "WI2oyD0b": {
        "id": "WI2oyD0b",
        "title": "Synthesis and Characterization of New Benzothiazole-Pyrimidine Chromophores",
        "authors": [
            {
                "name": "LIU Rong",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "ZHOU Yu-Ming",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "HE Man",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "DAI Jia",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "CUI Yi-Ping",
                "org": "College of Electronics and Engineering,Southeast University,Nanjing "
            },
            {
                "name": "ZHANG Tong",
                "org": "College of Electronics and Engineering,Southeast University,Nanjing "
            }
        ],
        "venue": "chinese journal of applied chemistry",
        "keywords": [
            "benzothiazole",
            "pyrimidine",
            "second order nonlinear optical properties",
            "nonlinear"
        ],
        "year": 2009
    },
    "Wcd1KPFF": {
        "id": "Wcd1KPFF",
        "title": "Synthesis and Nonlinear Optical Properties of Fluorinated Polyimides Containing Benzothiazole",
        "authors": [
            {
                "name": "HE Man",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "ZHOU Yu-Ming",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "MIAO Jun-Liang",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "LIU Cheng",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "FANG Cheng",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "CUI Yi-Ping",
                "org": "School of Electronic Science and Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering, Southeast University, Nanjing , P. R. China"
            }
        ],
        "venue": "acta physico-chimica sinica",
        "keywords": [
            "Nonlinear optical",
            "Thermal stability",
            "Electrooptic coefficient",
            "Benzothiazolylazo chromophore molecular",
            "Fluorine-containing polyimide"
        ],
        "year": 2010
    },
    "qWgQrXWv": {
        "id": "qWgQrXWv",
        "title": "Preparation and Characterization of Novel PUT/SiO_2 Nanocomposite Material",
        "authors": [
            {
                "name": "ZHOU Yu-Ming",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "ZHONG Ai-Min",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "HE Man",
                "org": "School of Chemistry and Chemical Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "CUI Yi-Ping",
                "org": "School of Electronic Science and Engineering, Southeast University, Nanjing , P. R. China"
            },
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering, Southeast University, Nanjing , P. R. China"
            }
        ],
        "venue": "acta physico-chimica sinica",
        "keywords": [
            "thiazole",
            "composite material",
            "nonlinear optics",
            "polyurethane",
            "silicon dioxide",
            "sol gel process",
            "second order"
        ],
        "year": 2007
    },
    "wHkVyhrT": {
        "id": "wHkVyhrT",
        "title": "Study of Characteristics of Ring Resonator in Integrated Optical Waveguide Gyroscope",
        "abstract": "Characteristics of ring resonator in integrated optical waveguide gyroscope are key factors in design and fabrication of ring resonator.General expressions of intensity ratio of light in ring and output port were deduced according to multiple-beam interference,and optimum resonance condition was given.Amplitude of intensity of resonance wave in the ring was analyzed under the condition of optimum resonance and non-optimum resonance,and relationship of these parameters is demonstrated.",
        "keywords": [
            "multiple-beam interference",
            "optical waveguide gyroscope",
            "optimum resonance condition",
            "resonance characteristics"
        ],
        "authors": [
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHANG Xiao-yang",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "JI Chun-ling",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "CUI Yi-ping",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            }
        ],
        "venue": "Chinese Journal of Sensors and Actuators",
        "year": 2006
    },
    "UVQiR3Ag": {
        "id": "UVQiR3Ag",
        "title": "Fabrication and characterization of a high performance polycarbonate film",
        "abstract": "A high performance polycarbonate(PC) thin film was investigated.The PC solutions with different concentration were spin coated to fabricate smooth PC films on glass substrate.Both the thermal and optical properties of this PC powder and film were characterized.The glass transition temperature(Tg) of this PC was measured by DSC.The absorption spectrum and thereafter optical loss for the PC films were determined by spectrum analyzer.The films refractive index,thickness,and dn/dt were analyzed by prism coupler.Besides,the influence of the spin coating conditions on the film properties was also investigated.By the characterization,this novel PC material exhibit high Tg and low optical loss,which indicates it is promising to fabricate the core layer for optical waveguide devices.",
        "keywords": [
            "Glass transition temperature",
            "Polycarbonate",
            "Spin coating"
        ],
        "authors": [
            {
                "name": "JI Chun-ling",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHANG Xiao-yang",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "CUI Yi-ping",
                "org": "School of Electronic Science and Engineering,Southeast University,Nanjing ,China"
            },
            {
                "name": "ZHU Jing-song",
                "org": "National Center for Nano Science and Technology,Beijing ,China"
            },
            {
                "name": "ZHOU Jing-lun",
                "org": "National Center for Nano Science and Technology,Beijing ,China"
            },
            {
                "name": "FAN Jiang-feng",
                "org": "National Center for Nano Science and Technology,Beijing ,China"
            }
        ],
        "venue": "Infrared and Laser Engineering",
        "year": 2007
    },
    "1ramd2zo": {
        "id": "1ramd2zo",
        "title": "Comprehensive evaluation of a cost-effective method of culturing Chlorella pyrenoidosa with unsterilized piggery wastewater for biofuel production.",
        "abstract": "The study provided a comprehensive evaluation of culturing  in unsterilized piggery wastewater for biofuel production. The results indicated that this cost-effective method is feasible but has considerable room for improving. More importantly, this study elucidated the mutual effects between algae and other microbes. In particular, a detrimental effect of the obligate parasite Vampirovibrionales on algal biomass and lipid production was found.",
        "keywords": [
            "Biofuel",
            "Chlorella pyrenoidosa",
            "Nutrient removal",
            "Unsterilized piggery wastewater",
            "Vampirovibrionales"
        ],
        "authors": [
            {
                "name": "Weiguo Zhang",
                "org": "Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, 50 Zhongling Street, Nanjing, 210014 China."
            },
            {
                "name": "Jiangye Li",
                "org": "1Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjng, 210014 China."
            },
            {
                "name": "Zhenhua Zhang",
                "org": "1Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjng, 210014 China."
            },
            {
                "name": "Guangping Fan",
                "org": "1Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjng, 210014 China."
            },
            {
                "name": "Yuchun Ai",
                "org": "1Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences, 50 Zhongling Street, Nanjng, 210014 China."
            },
            {
                "name": "Yan Gao",
                "org": "Key Lab of Food Quality and Safety of Jiangsu Province-State Key Laboratory Breeding Base, 50 Zhongling Street, Nanjing, 210014 China."
            },
            {
                "name": "Gang Pan",
                "org": "3School of Animal Rural and Environmental Sciences, Nottingham Trent University, Brackenhurst, Southwell, Nottinghamshire NG25 0QF UK."
            }
        ],
        "venue": "Biotechnology for biofuels",
        "year": 2019
    },
    "9egmZZqu": {
        "id": "9egmZZqu",
        "title": "Comprehensive evaluation of a cost-effective method of culturing Chlorella pyrenoidosa with unsterilized piggery wastewater for biofuel production",
        "abstract": "BackgroundThe utilization of Chlorella for the dual goals of biofuel production and wastewater nutrient removal is highly attractive. Moreover, this technology combined with flue gas (rich in CO2) cleaning is considered to be an effective way of improving biofuel production. However, the sterilization of wastewater is an energy-consuming step. This study aimed to comprehensively evaluate a cost-effective method of culturing Chlorella pyrenoidosa in unsterilized piggery wastewater for biofuel production by sparging air or simulated flue gas, including algal biomass production, lipid production, nutrient removal rate and the mutual effects between algae and other microbes.",
        "keywords": "",
        "authors": [
            {
                "name": "Weiguo Zhang",
                "org": "Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences"
            },
            {
                "name": "Jiangye Li",
                "org": "Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences"
            },
            {
                "name": "Zhenhua Zhang",
                "org": "Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences"
            },
            {
                "name": "Guangping Fan",
                "org": "Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences"
            },
            {
                "name": "Yuchun Ai",
                "org": "Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences"
            },
            {
                "name": "Yan Gao",
                "org": "Institute of Agricultural Resources and Environment, Jiangsu Academy of Agricultural Sciences"
            },
            {
                "name": "Gang Pan",
                "org": "Nottingham Trent University"
            }
        ],
        "venue": "Biotechnology for Biofuels",
        "year": 2019
    },
    "nMP4njKD": {
        "authors": [
            {
                "name": "Bo Zhou",
                "org": "Department of Automation"
            },
            {
                "name": "Hao Ye",
                "org": "Department of Automation"
            }
        ],
        "title": "A study of polynomial fit-based methods for qualitative trend analysis",
        "abstract": "Qualitative trend analysis (QTA) of sensor data is a useful tool for process monitoring, fault diagnosis and data mining. However, because of the varying background noise characteristics and different scales of sensor trends, automated and reliable trend extraction remains a challenge for trend-based analysis systems. In this paper, several new polynomial fit-based trend extraction algorithms are first developed, which determine the parameters automatically in the hypothesis testing framework. An existing trend analysis method developed by Dash et al. (2004) is then modified and added to the abovementioned trend extraction algorithms, which form a complete solution for QTA. The performance comparison of these algorithms is made on a set of simulated data and Tennessee Eastman process data based on several metrics.",
        "keywords": [
            "Polynomial fit",
            "Process monitoring and diagnosis",
            "Qualitative trend analysis",
            "Trend extraction"
        ],
        "venue": "Journal of Process Control",
        "year": 2016,
        "id": "nMP4njKD"
    },
    "JCURC69H": {
        "authors": [
            {
                "name": "Bo Zhou",
                "org": "Department of Automation"
            },
            {
                "name": "Hao Ye",
                "org": "Department of Automation"
            },
            {
                "name": "Haifeng Zhang",
                "org": "Guangxi Liuzhou Iron and Steel (Group) Company"
            },
            {
                "name": "Mingliang Li",
                "org": "Guangxi Liuzhou Iron and Steel (Group) Company"
            }
        ],
        "title": "Process monitoring of iron-making process in a blast furnace with PCA-based methods",
        "abstract": "Incidents happening in the blast furnace will strongly affect the stability and smoothness of the iron-making process. Thus far, diagnosis of abnormalities in furnaces still mainly relies on the personal experiences of individual workers in many iron works. In this paper, principal component analysis (PCA)-based algorithms are developed to monitor the iron-making process and achieve early abnormality detection. Because the process exhibits a non-normal distribution and a time-varying nature in the measurement data, a static convex hull-based PCA algorithm (SCHPCA) which replaces the traditional T",
        "keywords": [
            "Blast furnace",
            "Fault diagnosis",
            "Iron-making process",
            "Principal component analysis",
            "Process monitoring"
        ],
        "venue": "Control Engineering Practice",
        "year": 2016,
        "id": "JCURC69H"
    },
    "VDf1xQZg": {
        "id": "VDf1xQZg",
        "title": "Exploration Situation and Research Development of \u201cContinuous\u201d Petroleum Reservoirs",
        "authors": [
            {
                "name": "LI Chun-xia",
                "org": "Shaanxi Yanchang Petroleum%%#Group%%# Co.,Ltd.Research Institute,Shaanxi Xi\u2019an ,China"
            },
            {
                "name": "JI Hong",
                "org": "Xi\u2019an Shiyou University,Shaanxi Xi\u2019an ,China"
            },
            {
                "name": "ZHAO Wei-wei",
                "org": "Xi\u2019an Shiyou University,Shaanxi Xi\u2019an ,China"
            },
            {
                "name": "WANG Xiao-duo",
                "org": "Shaanxi Yanchang Petroleum%%#Group%%# Co.,Ltd.Research Institute,Shaanxi Xi\u2019an ,China"
            },
            {
                "name": "WANG Min",
                "org": "Shaanxi Yanchang Petroleum%%#Group%%# Co.,Ltd.Research Institute,Shaanxi Xi\u2019an ,China"
            }
        ],
        "venue": "liaoning chemical industry",
        "keywords": [
            "\"continuous\" petroleum reservoirs",
            "shale gas",
            "unconventional trap reservoir",
            "tight sandstone gas"
        ],
        "year": 2013
    },
    "x7T2Uvk6": {
        "id": "x7T2Uvk6",
        "title": "Quantitative method for fault lateral sealing ability based on seismic data and its application",
        "authors": [
            {
                "name": "LIU Jun-bang",
                "org": "State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing ,China"
            },
            {
                "name": "HAO Qi",
                "org": "Yanchang Petroleum%%#Group%%#CO.,Ltd Institute,Xi\ue6ad an ,China"
            },
            {
                "name": "LIANG Quan-sheng",
                "org": "Yanchang Petroleum%%#Group%%#CO.,Ltd Institute,Xi\ue6ad an ,China"
            },
            {
                "name": "LIU Zhen",
                "org": "State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing ,China"
            },
            {
                "name": "FAN Chun-mei",
                "org": "Yanchang Petroleum%%#Group%%#CO.,Ltd Institute,Xi\ue6ad an ,China"
            },
            {
                "name": "WANG Xiao-dong",
                "org": "2nd Oil Production Plant of Dagang Oilfield Company,Cangzhou ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Yanchang Petroleum%%#Group%%#CO.,Ltd Institute,Xi\ue6ad an ,China"
            },
            {
                "name": "HE Xiao-hu",
                "org": "Research Institute of Zhanjiang Branch Institute,CNOOC,Zhanjiang ,China"
            }
        ],
        "venue": "journal of china university of petroleum(edition of natural science)",
        "keywords": [
            "fault lateral sealing ability",
            "Dongdaohaizi fracture belt",
            "shale smear factor",
            "critical shale smear factor for oil and gas",
            "lateral sealing ability of reservoir forming period"
        ],
        "year": 2010
    },
    "b0hIpt9M": {
        "id": "b0hIpt9M",
        "title": "Structural characteristics and hydrocarbon accumulation in the buried hills of the Liaoxi low salient,the Liaodong Bay Depression",
        "authors": [
            {
                "name": "Yang Minghui",
                "org": "Faculty of Natural Resource & Information Technology,China University of Petroleum,Beijing ,China;State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing ,China"
            },
            {
                "name": "Zhou Xinhuai",
                "org": "CNOOC Tianjin Company,Tianjin ,China"
            },
            {
                "name": "Wei Gang",
                "org": "CNOOC Tianjin Company,Tianjin ,China"
            },
            {
                "name": "Liu Le",
                "org": "Research Institute of BGP,PetroChina,Zhuozhou,Hebei ,China"
            },
            {
                "name": "Li Chunxia",
                "org": "Research Institute of Yanchang Petroleum Group Co.Ltd.,Xi'an,Shanxi ,China"
            },
            {
                "name": "Zheng Xiaofeng",
                "org": "Research Institute of Exploration and Development,PetroChina Jidong Oilfield,Tangshan,Hebei ,China"
            }
        ],
        "venue": "oil & gas geology",
        "keywords": [
            "Liaoxi low salient",
            "buried hill structure",
            "Liaodong Bay Depression",
            "hydrocarbon accumulation"
        ],
        "year": 2009
    },
    "khLf2KfH": {
        "id": "khLf2KfH",
        "title": "Pool features and hydrocarbon distribution of the buried hills in the eastern sag of Liaohe depression,China",
        "authors": [
            {
                "name": "HAO Qi",
                "org": "1.Key Laboratory of Hydrocarbon Accumulation Mechanism in China University of Petroleum,Ministry of Education,Beijing ,China"
            },
            {
                "name": "ZHA Ming",
                "org": "Shool of Geo-Resource and Information,China University of Petroleum, Dongying ,China"
            },
            {
                "name": "LIU Zhen",
                "org": "1.Key Laboratory of Hydrocarbon Accumulation Mechanism in China University of Petroleum,Ministry of Education,Beijing ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "1.Key Laboratory of Hydrocarbon Accumulation Mechanism in China University of Petroleum,Ministry of Education,Beijing ,China"
            }
        ],
        "venue": "journal of chengdu university of technology(science & technology edition)",
        "keywords": [
            "buried hill",
            "pool",
            "eastern Sag",
            "Liaohe depression"
        ],
        "year": 2006
    },
    "VzTMUC3m": {
        "id": "VzTMUC3m",
        "title": "Fractures of the Upper Paleozoic in Northern Shaanxi Slope and Its Natural Gas Accumulation Significance",
        "authors": [
            {
                "name": "Wan Yongping",
                "org": "School of Earth Sciences and Resource,China University of Geosciences,Beijing ,China;Institute of Shaanxi Yanchang Petroleum%%#Group%%# Company Limited,Xi'an ,China"
            },
            {
                "name": "Wang Genhou",
                "org": "School of Earth Sciences and Resource,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "Gui Rong",
                "org": "School of Earth Sciences and Resource,China University of Geosciences,Beijing ,China"
            },
            {
                "name": "Li Chunxia",
                "org": "Institute of Shaanxi Yanchang Petroleum%%#Group%%# Company Limited,Xi'an ,China"
            },
            {
                "name": "Yin Xiao",
                "org": "Institute of Shaanxi Yanchang Petroleum%%#Group%%# Company Limited,Xi'an ,China"
            },
            {
                "name": "Zhou Jinsong",
                "org": "Institute of Shaanxi Yanchang Petroleum%%#Group%%# Company Limited,Xi'an ,China"
            }
        ],
        "venue": "journal of jilin university(earth science edition)",
        "keywords": [
            "natural gas",
            "migration channel",
            "Upper Paleozoic",
            "fracture",
            "accumulation",
            "northern Shaanxi slope"
        ],
        "year": 2013
    },
    "39azY6vd": {
        "id": "39azY6vd",
        "title": "Characters and Controlling Factors on the Archean Fracture-type Reservoirs of the Ciyutuo Buried Hill in the Liaohe Basin",
        "authors": [
            {
                "name": "HAO Qi"
            },
            {
                "name": "LIU Zhen"
            },
            {
                "name": "ZHA Ming",
                "org": "Faculty of Geo-Resource and Information,China University of Petroleum,Dongying,Shandong ,China"
            },
            {
                "name": "LI Chun-xia"
            }
        ],
        "venue": "journal of jilin university(earth science edition)",
        "keywords": [
            "Liaohe",
            "Archeozoic",
            "reservoir character",
            "Ciyutuo buried hill",
            "fracture",
            "controlling factor"
        ],
        "year": 2006
    },
    "ewaea9Wa": {
        "id": "ewaea9Wa",
        "title": "Diagenetic Facies and Micro-pore Structure of Chang 6 Reservoir in Yanchang Formation,Huaqing Area,Ordos Basin",
        "authors": [
            {
                "name": "SHI Tiao-tiao",
                "org": "State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi'an,Shaanxi ,China"
            },
            {
                "name": "SUN Wei",
                "org": "State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi'an,Shaanxi ,China"
            },
            {
                "name": "ZHANG Chuang",
                "org": "Research Institute,Shaanxi Yanchang Petroleum%%#Group%%#Co.,Ltd.,Xi'an,Shaanxi ,China"
            },
            {
                "name": "LIANG Xiao-wei",
                "org": "National Engineering Laboratory for Exploration and Development of Low-Permeability Oil & Gas Fields,Xi'an,Shaanxi ,China;Research Institute of Exploration and Development,Changing Oilfield Company,PetroChina,Xi'an,Shaanxi ,China"
            },
            {
                "name": "HE Sheng-ping",
                "org": "National Engineering Laboratory for Exploration and Development of Low-Permeability Oil & Gas Fields,Xi'an,Shaanxi ,China;Research Institute of Exploration and Development,Changing Oilfield Company,PetroChina,Xi'an,Shaanxi ,China"
            },
            {
                "name": "REN Da-zhong",
                "org": "State Key Laboratory of Continental Dynamics,Department of Geology,Northwest University,Xi'an,Shaanxi ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Research Institute,Shaanxi Yanchang Petroleum%%#Group%%#Co.,Ltd.,Xi'an,Shaanxi ,China"
            }
        ],
        "venue": "geoscience",
        "keywords": [
            "Yanchang Formation",
            "micro-pore structure",
            "Ordos Basin",
            "diagenetic facies",
            "Chang 6 reservoir",
            "Huaqing area"
        ],
        "year": 2012
    },
    "H4XWgbtF": {
        "id": "H4XWgbtF",
        "title": "Segment, Linkage, and Extensional Fault-Related Fold in Western Liaodong Bay Subbasin, Northeastern Bohai Sea, China",
        "authors": [
            {
                "name": "Yang Minghui",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Zhou Xinhuai",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Wei Gang",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Liu Le",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Li Chunxia",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Zheng Xiaofeng",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Liu Xiaojian",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            },
            {
                "name": "Gao Libao",
                "org": " No. 203 Research Institute of Nuclear Industry, Xianyang , China"
            }
        ],
        "venue": "\u4e2d\u56fd\u5730\u8d28\u5927\u5b66\u5b66\u62a5(\u82f1\u6587\u7248)",
        "keywords": [
            "extension",
            "Liaodong Bay sub- basin",
            "Bohai Sea.",
            "fault linkage",
            "fault segment",
            "fault-related folding"
        ],
        "year": 2008
    },
    "uorvo35z": {
        "id": "uorvo35z",
        "title": "Fractured reservoirs in metamorphic buried-hills in the Liaoxi low uplift and their hydrocarbon accumulation conditions",
        "authors": [
            {
                "name": "Liu Le",
                "org": "Basin and Reservoir Research Center,China University of Petroleum,Beijing ,China"
            },
            {
                "name": "Yang Minghui",
                "org": "Basin and Reservoir Research Center,China University of Petroleum,Beijing ,China;State key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing ,China"
            },
            {
                "name": "Li Chunxia",
                "org": "Research Institute of Yanchang Petroleum Group Co.Ltd.,Xi'an,Shannxi ,China"
            },
            {
                "name": "Zheng Xiaofeng",
                "org": "Research Institute of Exploration and Development,PetroChina Jidong Oilfield Commpany,Tangshan,Hebei ,China"
            }
        ],
        "venue": "oil & gas geology",
        "keywords": [
            "imaging logging response",
            "Liaoxi low uplift",
            "Bohai Bay Basin",
            "fractured reservoir",
            "metamorphic buried-hill"
        ],
        "year": 2009
    },
    "kBKKc1AK": {
        "id": "kBKKc1AK",
        "title": "Pre-stack density inversion in reservoir and hydrocarbon prediction application in Yong block, Subei Basin",
        "authors": [
            {
                "name": "Tong Minbo",
                "org": " et al.Research Institute of Shaanxi Yanchang Petroleum %%#Group%%# Co. ,Ltd,Xi'an City,Shaanxi Province, ,China"
            },
            {
                "name": "Gao Fei",
                "org": " et al.Research Institute of Shaanxi Yanchang Petroleum %%#Group%%# Co. ,Ltd,Xi'an City,Shaanxi Province, ,China"
            },
            {
                "name": "Li Chunxia",
                "org": " et al.Research Institute of Shaanxi Yanchang Petroleum %%#Group%%# Co. ,Ltd,Xi'an City,Shaanxi Province, ,China"
            }
        ],
        "venue": "petroleum geology and recovery efficiency",
        "keywords": [
            "petrophysics",
            "pre-stack seismic",
            "sensitivity",
            "hydrocarbon prediction",
            "density inversion"
        ],
        "year": 2012
    },
    "aCaAqjRR": {
        "id": "aCaAqjRR",
        "title": "Control of critical physical properties of reservoir to the hydrocarbon accumulation in lithological traps:taking Jurassic of Baijiahai uplift in the eastern Junggar Basin as an example",
        "authors": [
            {
                "name": "JIN Bo",
                "org": "School of Energy Resources,China University of Geosciences%%#Beijing%%#,Beijing ,China;Drilling Interpretation Center,Greatwall Drilling Company,CNPC,Beijing ,China"
            },
            {
                "name": "HAN Jun",
                "org": "Coalbed Methane Company Limited,CNPC,Beijing ,China"
            },
            {
                "name": "JIANG Shu-yun",
                "org": "Engineering Service Branch,Greatwall Drilling Company,CNPC,Beijing ,China"
            },
            {
                "name": "LIANG Quan-sheng",
                "org": "Research Institute,Shaanxi Yangchang Petroleum%%#Group%%# Co.Ltd.,Xi'an ,Shaanxi,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Research Institute,Shaanxi Yangchang Petroleum%%#Group%%# Co.Ltd.,Xi'an ,Shaanxi,China"
            }
        ],
        "venue": "journal of xi'an shiyou university(natural science edition)",
        "keywords": [
            "lithological trap",
            "Jurassic",
            "critical physical property of reservoir",
            "hydrocarbon accumulation",
            "Baijiahai uplift"
        ],
        "year": 2012
    },
    "kS4bc1uR": {
        "id": "kS4bc1uR",
        "title": "Structural Characteristics and Hydrocarbon Accumulation of Relay Ramp in Liaoxi Low-uplift,Bohai Bay Basin",
        "authors": [
            {
                "name": "YANG Ming-hui",
                "org": "College of Geosciences,China University of Petroleum,Beijing ,China;State Key Laboratory of Petroleum Resource and Prospecting,China University of Petroleum,Beijing ,China"
            },
            {
                "name": "ZHOU Xin-huai",
                "org": "Research Institute of Tianjin Branch,CNOOC,Tianjin ,China"
            },
            {
                "name": "WEI Gang",
                "org": "Research Institute of Tianjin Branch,CNOOC,Tianjin ,China"
            },
            {
                "name": "LIU Le",
                "org": "Bureau of Geophysical Prospecting Incorporation,CNPC,Zhuozhou,Hebei ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Research Institute of Yanchang Petroleum Group Co.Ltd.,Xi'an,Shaanxi ,China"
            },
            {
                "name": "ZHENG Xiao-feng",
                "org": "Research Institute of Exploration and Development,Jidong Oilfield,PetroChina,Tangshan,Hebei ,China"
            }
        ],
        "venue": "geoscience",
        "keywords": [
            "hydrocarbon reservoir",
            "Bohai bay basin",
            "Liaoxi low-uplift",
            "transfer structure",
            "hydrocarbon accumulation",
            "relay ramp"
        ],
        "year": 2010
    },
    "dM2F30mi": {
        "id": "dM2F30mi",
        "title": "Meta-analysis on correlation of CD14-159C/T polymorphism to coronary disease",
        "abstract": "Objective To study the correlation between the CD14 gene promoter polymorphism-159C/T and coronary heart disease(CHD) by means of Meta-analysis. Methods All case-controll studies were searched,which were about correlation of CD14-159C/T polymorphism to coronary disease published before March 1st,2012 in the PubMed,Web of science,CNKI,Wanfang and CBM datebases.Search words to find appropriate studies were coronary heart disease,coronary artery disease,coronary disease,CD14 and genetic polymorphism.Publication bias was tested by funnel plot and the combined odd ratios(OR)then were calculated.Three polymorphous models of CC vs CT+TT\u3001TT vs CC+CC and T vs C based on risk gene exposure group and non risk gene exposure group were supposed and used to calculate OR.The software Review Manager(version 5.0) was used for Meta-analysis. Results Seven appropriate studies were adopted.Integrated 2 005 cases and 1 433 controls from studies adopted were analyzed.The results showed OR of polymorphous models of CC vs CT+TT,TT vs CC+CT and allele T vs the allele C were respectively 0.64(P>0.05)and 1.33(P<0.01)and 1.31(P<0.05).After rejected two studies about different race,corresponding OR above three polymorphous models were 0.39(P<0.01),1.76(P<0.01)and 1.68(P<0.01)respectively. Conclusions It is indicated that the-159C/T polymorphism in CD14 gene promoter is significantly associated with increased risk of coronary disease,the allele T may be a genetic risk factor for coronary disease.",
        "keywords": [
            "Coronary disease",
            "Meta-analysis",
            "Polymorphism",
            "CD14"
        ],
        "authors": [
            {
                "name": "MA Jian-hua",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            },
            {
                "name": "CHEN Yan-li",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            },
            {
                "name": "LI Xin",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            },
            {
                "name": "ZHANG Ge-xiang",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            },
            {
                "name": "WANG Yu",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            },
            {
                "name": "WEN Jian-qiang",
                "org": "*School of Public Health,Lanzhou University,Lanzhou,Gansu ,China"
            }
        ],
        "venue": "Chronic Pathematology Journal",
        "year": 2013
    },
    "gN163CMT": {
        "id": "gN163CMT",
        "title": "Determination of organic acids in Jiangshui by high performance liquid chromatography",
        "abstract": "A HPLC method for rapid determination of four organic acids in Jiangshui was developed in this paper.Agilent ZORBAX SB-AQ column(250 mm\u00d74.6 mm,5\u03bcm) was used at 30\u2103.The mobile phase was CH3OH\u2236 0.01 mol/L KH2PO4(0.5\u2236 99.5,pH=2.0).The flow rate was 0.6 mL/min and the detection wavelength was set at 210 nm.The injection volumes were 20 \u03bcL for each run.Based on the above optimizing chromatogram conditions,four organic acids,including tartaric acid,lactic acid,acetic acid and fumaric acid,were separated satisfactorily.The intra-day and inter-day precision(RSD%) for the analytes ranged from 0.6% to 1.8% and from 1.7% to 4.2%,respectively.The average recovery factors were from 81.0% to 116.0%.The results showed that developed method was successfully applied for the detection and isolation of four organic acids in Jiangshui.",
        "keywords": [
            "HPLC",
            "organic acid",
            "Jiangshui"
        ],
        "authors": [
            {
                "name": "Zhang Pei",
                "org": "Institute of Nutrition and Food Hygiene,of Public Health,Lanzhou University,Lanzhou ,China"
            },
            {
                "name": "Li Xin",
                "org": "Institute of Nutrition and Food Hygiene,of Public Health,Lanzhou University,Lanzhou ,China"
            },
            {
                "name": "Liu Yun",
                "org": "Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 73000,China"
            },
            {
                "name": "Liu Ye-wei",
                "org": "Institute of Nutrition and Food Hygiene,of Public Health,Lanzhou University,Lanzhou ,China"
            },
            {
                "name": "Luo Shan",
                "org": "Institute of Nutrition and Food Hygiene,of Public Health,Lanzhou University,Lanzhou ,China"
            },
            {
                "name": "Di Duo-long",
                "org": "Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province,Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 73000,China"
            },
            {
                "name": "Tang Yun-chang",
                "org": "Institute of Nutrition and Food Hygiene,of Public Health,Lanzhou University,Lanzhou ,China"
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2013
    },
    "EfWfCvI9": {
        "authors": [
            {
                "name": "Xiaogang Xiong",
                "org": "Wuhan National Laboratory for Optoelectronic"
            },
            {
                "name": "Sihai Chen",
                "org": "Wuhan National Laboratory for Optoelectronic"
            },
            {
                "name": "Xin Wu",
                "org": "Wuhan National Laboratory for Optoelectronic"
            },
            {
                "name": "Benyi Shi",
                "org": "Wuhan National Laboratory for Optoelectronic"
            },
            {
                "name": "Wei Chen",
                "org": "Wuhan National Laboratory for Optoelectronic"
            }
        ],
        "title": "Linear control of laser scanner driven by voice coil motor",
        "abstract": "A laser scanner driven by voice coil motor (VCM) was introduced and parameters of the established model were identified. Due to lots of high frequency optical noise in feedback loop, conventional methods, the improved PID control algorithm and the inverse design method based on optimal 2-order property of ideal closed-loop, which usually used for precise tracking of optoelectronic, cannot be employed for this laser scanner. This willl introduce unstablity and oscillates. After analyzing reasons of causing oscillation, a so-called feedforward control method based on the two methods above was used to resolve the contradiction between the oscillation and steady state error. At the same time, a low-pass filter was placed in the feedback loop according to the situation where feedback loop is filled with noise. The proposed method not only stabilizes the laser scanner but also eliminates hysteresis during linear scanning.",
        "keywords": [
            "Fast steering mirror (FSM)",
            "Laser scanner",
            "Linear control",
            "Voice coil motor (VCM)"
        ],
        "venue": "Hongwai yu Jiguang Gongcheng/Infrared and Laser Engineering",
        "year": 2012,
        "id": "EfWfCvI9"
    },
    "5z4IL8qh": {
        "id": "5z4IL8qh",
        "title": "The International Conference on Intelligent Biology and Medicine (ICIBM) 2018: bioinformatics towards translational applications.",
        "abstract": "The 2018 International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held on June 10\u201312, 2018, in Los Angeles, California, USA. The conference consisted of a total of eleven scientific sessions, four tutorials, one poster session, four keynote talks and four eminent scholar talks, which covered a wild range of aspects of bioinformatics, medical informatics, systems biology and intelligent computing. Here, we summarize nine research articles selected for publishing in BMC Bioinformatics.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoming Liu",
                "org": ""
            },
            {
                "name": "Lei Xie",
                "org": ""
            },
            {
                "name": "Zhijin Wu",
                "org": ""
            },
            {
                "name": "Kai Wang",
                "org": ""
            },
            {
                "name": "Zhongming Zhao",
                "org": ""
            },
            {
                "name": "Jianhua Ruan",
                "org": ""
            },
            {
                "name": "Degui Zhi",
                "org": ""
            }
        ],
        "venue": "BMC Bioinformatics",
        "year": 2018
    },
    "BPFR40B7": {
        "id": "BPFR40B7",
        "title": "Comparison of different functional prediction scores using a gene-based permutation model for identifying cancer driver genes.",
        "abstract": "The new function prediction based approach not only predicted known cancer genes listed in the Cancer Gene Census (CGC), but also new candidate CDGs that are worth further investigation. The results showed the advantage of utilizing pan-genome deleteriousness prediction scores in function prediction based methods. Although VEST3 score, a deleteriousness prediction score for missense mutations, has the best performance in breast cancer, it was topped by CADD and Fathmm-MKL coding, two pan-genome deleteriousness prediction scores, in lung cancer.",
        "keywords": [
            "Bioinformatics",
            "Cancer genomics",
            "Computational evaluation",
            "Driver genes",
            "Function prediction method",
            "Whole genome sequencing"
        ],
        "authors": [
            {
                "name": "Alice Djotsa Nono",
                "org": "Human Genetics Center, UTHealth School of Public Health, Houston, TX, USA."
            },
            {
                "name": "Ken Chen",
                "org": "Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Present Address: USF Genomics, College of Public Health, University of South Florida, Tampa, FL, USA. xiaomingliu@health.usf.edu."
            }
        ],
        "venue": "BMC medical genomics",
        "year": 2019
    },
    "10yA6mcc": {
        "id": "10yA6mcc",
        "title": "Whole-genome sequencing study of serum peptide levels: the Atherosclerosis Risk in Communities study.",
        "abstract": "Oligopeptides are important markers of protein metabolism, as they are cleaved from larger polypeptides and proteins. Genetic association studies may help elucidate their origin and function. In 1,552 European Americans and 1,872 African Americans of the Atherosclerosis Risk in Communities study, we performed whole-genome and whole-exome sequencing and measured serum levels of 25 peptides. Common variants (minor allele frequency\u2009>\u20095%) were analysed individually. We grouped low-frequency variants (minor allele frequency\u2009\u2264\u20095%) by a genome-wide sliding window using region-based aggregate tests. Furthermore, low-frequency regulatory variants were grouped by gene, as were functional coding variants. All analyses were performed separately in each ancestry group and then meta-analysed. We identified 22 common variant associations with peptide levels (P-value\u2009<\u20094.2\u2009\u00d7\u200910-10), including 16 novel gene-peptide pairs. Notably, variants in kinin-kallikrein genes KNG1, F12, KLKB1, and ACE were associated with several different peptides. Variants in KLKB1 and ACE were associated with a fragment of complement component 3f. Both common variants and low-frequency coding variants in CPN1 were associated with a fibrinogen cleavage peptide. Four sliding windows were significantly associated with peptide levels (P-value\u2009<\u20094.2\u2009\u00d7\u200910-10). Our results highlight the importance of the kinin-kallikrein system in the regulation of serum peptide levels, strengthen the evidence for a broad link between the kinin-kallikrein and complement systems, and suggest a role of CPN1 in the conversion of fibrinogen to fibrin.",
        "keywords": "",
        "authors": [
            {
                "name": "Paul S de Vries",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            },
            {
                "name": "Bing Yu",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            },
            {
                "name": "Elena V Feofanova",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            },
            {
                "name": "Ginger A Metcalf",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030 TX, USA."
            },
            {
                "name": "Michael R Brown",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            },
            {
                "name": "Atefeh L Zeighami",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            },
            {
                "name": "Donna M Muzny",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030 TX, USA."
            },
            {
                "name": "Richard A Gibbs",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030 TX, USA."
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030 TX, USA."
            },
            {
                "name": "Alanna C Morrison",
                "org": "Department of Epidemiology, Human Genetics, and Environmental Sciences, Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, 77030 TX, USA."
            }
        ],
        "venue": "Human molecular genetics",
        "year": 2017
    },
    "3G1JVRqQ": {
        "id": "3G1JVRqQ",
        "title": "Next-Generation Sequencing in Human Genetic Studies: Genome Technologies and Applications to Human Genetic Studies.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Junwen Wang",
                "org": "College of Health Solutions, Arizona State University, Phoenix, Arizona, USAWang.Junwen@mayo.edu."
            },
            {
                "name": "Kai Wang",
                "org": "Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "College of Public Health, University of South Florida, Tampa, Florida, USA."
            },
            {
                "name": "Pak Sham",
                "org": "Centre for Genomic Sciences, Department of Psychiatry, State Key Laboratory in Cognitive and Brain Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China."
            },
            {
                "name": "Zhongming Zhao",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, Texas, USA."
            }
        ],
        "venue": "Human heredity",
        "year": 2019
    },
    "ePddJGHk": {
        "id": "ePddJGHk",
        "title": "The population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequences.",
        "abstract": "Rhesus macaques (Macaca mulatta) are the most widely used nonhuman primate in biomedical research, have the largest natural geographic distribution of any nonhuman primate, and have been the focus of much evolutionary and behavioral investigation. Consequently, rhesus macaques are one of the most thoroughly studied nonhuman primate species. However, little is known about genome-wide genetic variation in this species. A detailed understanding of extant genomic variation among rhesus macaques has implications for the use of this species as a model for studies of human health and disease, as well as for evolutionary population genomics. Whole-genome sequencing analysis of 133 rhesus macaques revealed more than 43.7 million single-nucleotide variants, including thousands predicted to alter protein sequences, transcript splicing, and transcription factor binding sites. Rhesus macaques exhibit 2.5-fold higher overall nucleotide diversity and slightly elevated putative functional variation compared with humans. This functional variation in macaques provides opportunities for analyses of coding and noncoding variation, and its cellular consequences. Despite modestly higher levels of nonsynonymous variation in the macaques, the estimated distribution of fitness effects and the ratio of nonsynonymous to synonymous variants suggest that purifying selection has had stronger effects in rhesus macaques than in humans. Demographic reconstructions indicate this species has experienced a consistently large but fluctuating population size. Overall, the results presented here provide new insights into the population genomics of nonhuman primates and expand genomic information directly relevant to primate models of human disease.",
        "keywords": "",
        "authors": [
            {
                "name": "Cheng Xue",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Muthuswamy Raveendran",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "R Alan Harris",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Gloria L Fawcett",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "University of Texas Health Science Center, Houston, Texas 77030, USA."
            },
            {
                "name": "Simon White",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Mahmoud Dahdouli",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "David Rio Deiros",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Jennifer E Below",
                "org": "University of Texas Health Science Center, Houston, Texas 77030, USA."
            },
            {
                "name": "William Salerno",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Laura Cox",
                "org": "Southwest National Primate Research Center, San Antonio, Texas 78227, USA."
            },
            {
                "name": "Guoping Fan",
                "org": "Department of Human Genetics, University of California, Los Angeles, California 90095, USA."
            },
            {
                "name": "Betsy Ferguson",
                "org": "Oregon National Primate Research Center, Beaverton, Oregon 97006, USA."
            },
            {
                "name": "Julie Horvath",
                "org": "Department of Evolutionary Anthropology, Duke University, Durham, North Carolina 27708, USA."
            },
            {
                "name": "Zach Johnson",
                "org": "Yerkes National Primate Research Center, Atlanta, Georgia 30322, USA."
            },
            {
                "name": "Sree Kanthaswamy",
                "org": "School of Mathematical and Natural Sciences, Arizona State University, Phoenix, Arizona 85004, USA."
            },
            {
                "name": "H Michael Kubisch",
                "org": "Tulane National Primate Research Center, Covington, Louisiana 70433, USA."
            },
            {
                "name": "Dahai Liu",
                "org": "Center for Stem Cell and Translational Medicine, Anhui University, Anhui, China 230601."
            },
            {
                "name": "Michael Platt",
                "org": "Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA."
            },
            {
                "name": "David G Smith",
                "org": "California National Primate Research Center, Davis, California 95616, USA."
            },
            {
                "name": "Binghua Sun",
                "org": "Center for Stem Cell and Translational Medicine, Anhui University, Anhui, China 230601."
            },
            {
                "name": "Eric J Vallender",
                "org": "New England National Primate Research Center, Southborough, Massachusetts 01772, USA."
            },
            {
                "name": "Feng Wang",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Roger W Wiseman",
                "org": "Wisconsin National Primate Research Center, Madison, Wisconsin 53711, USA."
            },
            {
                "name": "Rui Chen",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Donna M Muzny",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Richard A Gibbs",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Fuli Yu",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA."
            },
            {
                "name": "Jeffrey Rogers",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA."
            }
        ],
        "venue": "Genome research",
        "year": 2016
    },
    "dTI9WfLf": {
        "id": "dTI9WfLf",
        "title": "Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study.",
        "abstract": "Small molecule lipid-related metabolites are important components of fatty acid and steroid metabolism, two important contributors to human health. This study investigated the extent to which rare and common genetic variants spanning the human genome influence the lipid-related metabolome. Sequence data from 1,552 European-Americans (EA) and 1,872 African-Americans (AA) were analyzed to examine the impact of common and rare variants on the levels of 102 circulating lipid-related metabolites measured by a combination of chromatography and mass spectroscopy. We conducted single variant tests (minor allele frequency [MAF]>5%, statistical significance p-value\u22642.45\u00d710) and tests aggregating rare variants (MAF\u22645%) across multiple genomic motifs, such as coding regions and regulatory domains, and sliding windows. Multiethnic meta-analyses detected 53 lipid-related metabolites-locus pairs, which were inspected for evidence of consistent signal between the two ethnic groups. Thirty eight lipid-related metabolite-genomic region associations were consistent across ethnicities, among which seven were novel. The regions contain genes that are related to metabolite transport () and metabolism (, , ). Six of the seven novel findings lie in expression quantitative trait loci affecting the expression levels of 14 surrounding genes in multiple tissues. Imputed expression levels of 10 of the affected genes were associated with four corresponding lipid-related traits in at least one tissue. Our findings offer valuable insight into circulating lipid-related metabolite regulation in a multiethnic population.",
        "keywords": [
            "lipids",
            "metabolome",
            "rare variants",
            "whole genome sequencing"
        ],
        "authors": [
            {
                "name": "Elena V Feofanova",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Bing Yu",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Ginger A Metcalf",
                "org": "Baylor College of Medicine."
            },
            {
                "name": "Xiaoming Liu",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Donna Muzny",
                "org": "Baylor College of Medicine."
            },
            {
                "name": "Jennifer E Below",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Lynne E Wagenknecht",
                "org": "Wake Forest School of Medicine."
            },
            {
                "name": "Richard A Gibbs",
                "org": "Baylor College of Medicine."
            },
            {
                "name": "Alanna C Morrison",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Eric Boerwinkle",
                "org": "University of Texas Health Science Center at Houston and Baylor College of Medicine Eric.Boerwinkle@uth.tmc.edu."
            }
        ],
        "venue": "Genetics",
        "year": 2018
    },
    "H0vJHn3C": {
        "id": "H0vJHn3C",
        "title": "The next generation of population-based spinal muscular atrophy carrier screening: comprehensive pan-ethnic SMN1 copy-number and sequence variant analysis by massively parallel sequencing.",
        "abstract": "We have developed a novel, comprehensive SMN1 copy-number and sequence variant analysis method by NGS that demonstrated improved SMA carrier detection rates across the entire population examined.Genet Med advance online publication 19 January 2017.",
        "keywords": "",
        "authors": [
            {
                "name": "Yanming Feng",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Xiaoyan Ge",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Linyan Meng",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Jennifer Scull",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Jianli Li",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Xia Tian",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Tao Zhang",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Weihong Jin",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Hanyin Cheng",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Xia Wang",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Mari Tokita",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Pengfei Liu",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Hui Mei",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Yue Wang",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Fangyuan Li",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Eric S Schmitt",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Wei V Zhang",
                "org": "Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA."
            },
            {
                "name": "Donna Muzny",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Shu Wen",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Zhao Chen",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Yaping Yang",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Arthur L Beaudet",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Current affiliation: AmCare Genomics Lab, Guangzhou, China."
            },
            {
                "name": "Christine M Eng",
                "org": "Baylor Genetics Laboratories, Houston, Texas, USA."
            },
            {
                "name": "Fan Xia",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Lee-Jun Wong",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            },
            {
                "name": "Jinglan Zhang",
                "org": "Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA."
            }
        ],
        "venue": "Genetics in medicine : official journal of the American College of Medical Genetics",
        "year": 2017
    },
    "CedNNzme": {
        "id": "CedNNzme",
        "title": "Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study.",
        "abstract": "Small molecule lipid-related metabolites are important components of fatty acid and steroid metabolism, two important contributors to human health. This study investigated the extent to which rare and common genetic variants spanning the human genome influence the lipid-related metabolome. Sequence data from 1,552 European-Americans (EA) and 1,872 African-Americans (AA) were analyzed to examine the impact of common and rare variants on the levels of 102 circulating lipid-related metabolites measured by a combination of chromatography and mass spectroscopy. We conducted single variant tests (minor allele frequency [MAF]>5%, statistical significance p-value\u22642.45\u00d710) and tests aggregating rare variants (MAF\u22645%) across multiple genomic motifs, such as coding regions and regulatory domains, and sliding windows. Multiethnic meta-analyses detected 53 lipid-related metabolites-locus pairs, which were inspected for evidence of consistent signal between the two ethnic groups. Thirty eight lipid-related metabolite-genomic region associations were consistent across ethnicities, among which seven were novel. The regions contain genes that are related to metabolite transport () and metabolism (, , ). Six of the seven novel findings lie in expression quantitative trait loci affecting the expression levels of 14 surrounding genes in multiple tissues. Imputed expression levels of 10 of the affected genes were associated with four corresponding lipid-related traits in at least one tissue. Our findings offer valuable insight into circulating lipid-related metabolite regulation in a multiethnic population.",
        "keywords": [
            "lipids",
            "metabolome",
            "rare variants",
            "whole genome sequencing"
        ],
        "authors": [
            {
                "name": "Elena V Feofanova",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Bing Yu",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Ginger A Metcalf",
                "org": "Baylor College of Medicine."
            },
            {
                "name": "Xiaoming Liu",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Donna Muzny",
                "org": "Baylor College of Medicine."
            },
            {
                "name": "Jennifer E Below",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Lynne E Wagenknecht",
                "org": "Wake Forest School of Medicine."
            },
            {
                "name": "Richard A Gibbs",
                "org": "Baylor College of Medicine."
            },
            {
                "name": "Alanna C Morrison",
                "org": "University of Texas Health Science Center at Houston."
            },
            {
                "name": "Eric Boerwinkle",
                "org": "University of Texas Health Science Center at Houston and Baylor College of Medicine Eric.Boerwinkle@uth.tmc.edu."
            }
        ],
        "venue": "Genetics",
        "year": 2018
    },
    "dCLTyyfs": {
        "id": "dCLTyyfs",
        "title": "Identification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis",
        "abstract": "We use whole genome sequence data and rare variant analysis methods to investigate a subset of the human serum metabolome, including 16 carnitine-related metabolites that are important components of mammalian energy metabolism. Medium pass sequence data consisting of 12,820,347 rare variants and serum metabolomics data were available on 1,456 individuals. By applying a penalization method, we identified two genes FGF8 and MDGA2 with significant effects on lysine and cis-4-decenoylcarnitine, respectively, using \u0394-AIC and likelihood ratio test statistics. Single variant analyses in these regions did not identify a single low-frequency variant (minor allele count u003e 3) responsible for the underlying signal. The results demonstrate the utility of whole genome sequence and innovative analyses for identifying candidate regions influencing complex phenotypes.",
        "keywords": "",
        "authors": [
            {
                "name": "Akram Yazdani",
                "org": "Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America"
            },
            {
                "name": "Azam Yazdani",
                "org": "Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America"
            }
        ],
        "venue": "Genetic Epidemiology",
        "year": 2016
    },
    "xk14BNjB": {
        "id": "xk14BNjB",
        "title": "WGSA: an annotation pipeline for human genome sequencing studies.",
        "abstract": "DNA sequencing technologies continue to make progress in increased throughput and quality, and decreased cost. As we transition from whole exome capture sequencing to whole genome sequencing (WGS), our ability to convert machine-generated variant calls, including single nucleotide variant (SNV) and insertion-deletion variants (indels), into human-interpretable knowledge has lagged far behind the ability to obtain enormous amounts of variants. To help narrow this gap, here we present WGSA (WGS annotator), a functional annotation pipeline for human genome sequencing studies, which is runnable out of the box on the Amazon Compute Cloud and is freely downloadable at (https://sites.google.com/site/jpopgen/wgsa/).Functional annotation is a key step in WGS analysis. In one way, annotation helps the analyst filter to a subset of elements of particular interest (eg, cell type specific enhancers), in another way annotation helps the investigators to increase the power of identifying phenotype-associated loci (eg, association test using functional prediction score as a weight) and interpret potentially interesting findings. Currently, there are several popular gene model based annotation tools, including ANNOVAR,1 SnpEff2 and the Ensembl Variant Effect Predictor (VEP).3 These can annotate a variety of protein coding and non-coding gene models from a range of species. It is well known among practitioners that different databases (eg, RefSeq4 and Ensembl5) use different models for \u2026",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoming Liu",
                "org": "University of Texas Health Science Center at Houston"
            },
            {
                "name": "Simon White",
                "org": "Baylor College of Medicine"
            },
            {
                "name": "Bo Peng",
                "org": ""
            },
            {
                "name": "Andrew D. Johnson",
                "org": "National Institutes of Health"
            },
            {
                "name": "Jennifer A. Brody",
                "org": "University of Washington"
            },
            {
                "name": "Alexander H. Li",
                "org": "University of Texas Health Science Center at Houston"
            },
            {
                "name": "Zhuoyi Huang",
                "org": ""
            },
            {
                "name": "Andrew Carroll",
                "org": ""
            },
            {
                "name": "Peng Wei",
                "org": "Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston"
            },
            {
                "name": "Richard A. Gibbs",
                "org": "Baylor College of Medicine"
            },
            {
                "name": "Robert J. Klein",
                "org": "Icahn School of Medicine at Mount Sinai (ISMMS)"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "University of Texas Health Science Center at Houston"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "University of Texas Health Science Center at Houston"
            }
        ],
        "venue": "Journal of Medical Genetics",
        "year": 2016
    },
    "Pi02akU9": {
        "id": "Pi02akU9",
        "title": "Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology",
        "abstract": "The increasing volume of whole-genome sequence (WGS) and multi-omics data requires new approaches for analysis. As one solution, we have created the cloud-based Analysis Commons, which brings together genotype and phenotype data from multiple studies in a setting that is accessible by multiple investigators. This framework addresses many of the challenges of multicenter WGS analyses, including data-sharing mechanisms, phenotype harmonization, integrated multi-omics analyses, annotation and computational flexibility. In this setting, the computational pipeline facilitates a sequence-to-discovery analysis workflow illustrated here by an analysis of plasma fibrinogen levels in 3,996 individuals from the National Heart, Lung, and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) WGS program. The Analysis Commons represents a novel model for translating WGS resources from a massive quantity of phenotypic and genomic data into knowledge of the determinants of health and disease risk in diverse human populations. Download references",
        "keywords": "",
        "authors": [
            {
                "name": "Jennifer A Brody",
                "org": "Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Alanna C Morrison",
                "org": "Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.;"
            },
            {
                "name": "Joshua C Bis",
                "org": "Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Jeffrey R O'Connell",
                "org": "Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore, Maryland, USA.;"
            },
            {
                "name": "Michael R Brown",
                "org": "Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.;"
            },
            {
                "name": "Jennifer E Huffman",
                "org": "Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts, USA.;"
            },
            {
                "name": "Darren C Ames",
                "org": "DNAnexus, Inc. Mountain View, California, USA.;"
            },
            {
                "name": "Andrew Carroll",
                "org": "DNAnexus, Inc. Mountain View, California, USA.;"
            },
            {
                "name": "Matthew P Conomos",
                "org": "Department of Biostatistics, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Stacey Gabriel",
                "org": "Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.;"
            },
            {
                "name": "Richard A Gibbs",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.;"
            },
            {
                "name": "Stephanie M Gogarten",
                "org": "Department of Biostatistics, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Namrata Gupta",
                "org": "Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.;"
            },
            {
                "name": "Cashell E Jaquish",
                "org": "National Heart, Lung, and Blood Institute, Division of Cardiovascular Sciences, Bethesda, Maryland, USA.;"
            },
            {
                "name": "Andrew D Johnson",
                "org": "Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts, USA.;"
            },
            {
                "name": "Joshua P Lewis",
                "org": "Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore, Maryland, USA.;"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.;"
            },
            {
                "name": "Alisa K Manning",
                "org": "Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.;Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.;Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, USA.;"
            },
            {
                "name": "George J Papanicolaou",
                "org": "National Heart, Lung, and Blood Institute, Division of Cardiovascular Sciences, Bethesda, Maryland, USA.;"
            },
            {
                "name": "Achilleas N Pitsillides",
                "org": "Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts, USA.;"
            },
            {
                "name": "Kenneth M Rice",
                "org": "Department of Biostatistics, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "William Salerno",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.;"
            },
            {
                "name": "Colleen M Sitlani",
                "org": "Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Nicholas L Smith",
                "org": "Department of Epidemiology, University of Washington, Seattle, Washington, USA.;Seattle Epidemiologic Research and Information Center, Department of Veteran Affairs Office of Research and Development, Seattle, Washington, USA.;Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.;Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium",
                "org": "Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA.;"
            },
            {
                "name": "The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium",
                "org": ""
            },
            {
                "name": "TOPMed Hematology and Hemostasis Working Group",
                "org": ""
            },
            {
                "name": "CHARGE Analysis and Bioinformatics Working Group",
                "org": ""
            },
            {
                "name": "Susan R Heckbert",
                "org": "Department of Epidemiology, University of Washington, Seattle, Washington, USA.;Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Cathy C Laurie",
                "org": "Department of Biostatistics, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "Braxton D Mitchell",
                "org": "Department of Medicine, Division of Endocrinology, Diabetes, and Nutrition, University of Maryland, Baltimore, Maryland, USA.;"
            },
            {
                "name": "Ramachandran S Vasan",
                "org": "Sections of Preventive Medicine and Epidemiology, and of Cardiology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.;Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA.;Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts, USA.;"
            },
            {
                "name": "Stephen S Rich",
                "org": "Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.;"
            },
            {
                "name": "Jerome I Rotter",
                "org": "Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.;"
            },
            {
                "name": "James G Wilson",
                "org": "Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, LABioMed at Harbor -UCLA Medical Center, Torrance, California, USA.;"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.;Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.;"
            },
            {
                "name": "Bruce M Psaty",
                "org": "Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.;Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA.;Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.;"
            },
            {
                "name": "L Adrienne Cupples",
                "org": "Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, USA.;Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts, USA.;"
            }
        ],
        "venue": "Nature Genetics",
        "year": 2017
    },
    "krLIFVEM": {
        "id": "krLIFVEM",
        "title": "iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes",
        "abstract": "Cancer results from the acquisition of somatic driver mutations. Several computational tools can predict driver genes from population-scale genomic data, but tools for analyzing personal cancer genomes are underdeveloped. Here we developed iCAGES, a novel statistical framework that infers driver variants by integrating contributions from coding, non-coding, and structural variants, identifies driver genes by combining genomic information and prior biological knowledge, then generates prioritized drug treatment. Analysis on The Cancer Genome Atlas (TCGA) data showed that iCAGES predicts whether patients respond to drug treatment (P\u2009=\u20090.006 by Fisher\u2019s exact test) and long-term survival (P\u2009=\u20090.003 from Cox regression). iCAGES is available at http://icages.wglab.org.",
        "keywords": [
            "Cancer genomics",
            " Machine learning",
            " Precision medicine",
            " Precision oncology",
            " TCGA"
        ],
        "authors": [
            {
                "name": "Chengliang Dong",
                "org": "University of Southern California"
            },
            {
                "name": "Yunfei Guo",
                "org": "University of Southern California"
            },
            {
                "name": "Hui Yang",
                "org": "University of Southern California"
            },
            {
                "name": "Zeyu He",
                "org": "Department of Computer Science, New York University, New York, USA"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Kai Wang",
                "org": ""
            },
            {
                "name": "Kai Wang",
                "org": ""
            }
        ],
        "venue": "Genome Medicine",
        "year": 2016
    },
    "x3j8Gcfi": {
        "id": "x3j8Gcfi",
        "title": "The International Conference on Intelligent Biology and Medicine (ICIBM) 2018: genomics meets medicine",
        "abstract": "During June 10\u201312, 2018, the International Conference on Intelligent Biology and Medicine (ICIBM 2018) was held in Los Angeles, California, USA. The conference included 11 scientific sessions, four tutorials, one poster session, four keynote talks and four eminent scholar talks that covered a wide range of topics ranging from 3D genome structure analysis and visualization, next generation sequencing analysis, computational drug discovery, medical informatics, cancer genomics to systems biology. While medical genomics has always been a main theme in ICIBM, this year we for the first time organized the BMC Medical Genomics Supplement for ICIBM. Here, we describe 15 ICIBM papers selected for publishing in BMC Medical Genomics.",
        "keywords": "",
        "authors": [
            {
                "name": "Degui Zhi",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Zhongming Zhao",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Fuhai Li",
                "org": "Department of Biomedical Informatics, Ohio State University, Columbus, USA"
            },
            {
                "name": "Zhijin Wu",
                "org": "Department of Biostatistics, Brown University, Providence, USA"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Kai Wang",
                "org": "Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children\u2019s Hospital of Philadelphia, Philadelphia, USA"
            },
            {
                "name": "Kai Wang",
                "org": "Raymond G. Perelman Center for Cellular and Molecular Therapeutics, Children\u2019s Hospital of Philadelphia, Philadelphia, USA"
            }
        ],
        "venue": "BMC Medical Genomics",
        "year": 2019
    },
    "iP7wFdou": {
        "id": "iP7wFdou",
        "title": "Colorectal Cancer-Associated Genes Are Associated with Tooth Agenesis and May Have a Role in Tooth Development.",
        "abstract": "Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. Here, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA and ATF1 rs11169552 (P\u2009=\u20094.36\u2009\u00d7\u200910) and DUSP10 rs6687758 (P\u2009=\u20091.25\u2009\u00d7\u200910), and positive association found with CASC8 rs10505477 (P\u2009=\u20098.2\u2009\u00d7\u200910). Additional CRC marker haplotypes were also significantly associated with TA. Genotyping an independent dataset consisting of 52 cases with TA and 427 controls confirmed the association with CASC8. Atf1 and Dusp10 expression was detected in the mouse developing teeth from early bud stages to the formation of the complete tooth, suggesting a potential role for these genes and their encoded proteins in tooth development. While their individual contributions in tooth development remain to be elucidated, these genes may be considered candidates to be tested in additional populations.",
        "keywords": "",
        "authors": [
            {
                "name": "Meredith A Williams",
                "org": "Center for Craniofacial Research, University of Texas Health Science Center School of Dentistry, Houston, 77054, USA."
            },
            {
                "name": "Claudia Biguetti",
                "org": "Department of Biological Sciences, University of Sao Paulo Bauru Dental School, Bauru, 17012, Brazil."
            },
            {
                "name": "Miguel Romero-Bustillos",
                "org": "Iowa Institute for Oral Health, College of Dentistry, University of Iowa, Iowa City, 52242, USA."
            },
            {
                "name": "Kanwal Maheshwari",
                "org": "Center for Craniofacial Research, University of Texas Health Science Center School of Dentistry, Houston, 77054, USA."
            },
            {
                "name": "Nuriye Dinckan",
                "org": "Department of Medical Genetics, School of Medicine, Istanbul University, Istanbul, 34093, Turkey."
            },
            {
                "name": "Franco Cavalla",
                "org": "Department of Biological Sciences, University of Sao Paulo Bauru Dental School, Bauru, 17012, Brazil."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Department of Epidemiology and Human Genetics, University of Texas Health Science Center School of Public Health, Houston, 77054, USA."
            },
            {
                "name": "Renato Silva",
                "org": "Pediatric Research Center, University of Texas Health Science Center McGovern Medical School, Houston, 77054, USA."
            },
            {
                "name": "Sercan Akyalcin",
                "org": "Department of Orthodontics, Tufts University, Boston, 02111, USA."
            },
            {
                "name": "Z Oya Uyguner",
                "org": "Department of Medical Genetics, School of Medicine, Istanbul University, Istanbul, 34093, Turkey."
            },
            {
                "name": "Alexandre R Vieira",
                "org": "Departments of Oral Biology and Pediatric Dentistry, University of Pittsburgh School of Dental Medicine, Pittsburgh, 15229, USA."
            },
            {
                "name": "Brad A Amendt",
                "org": "Craniofacial Anomalies Research Center, Carver College of Medicine, University of Iowa, Iowa City, 52242, USA."
            },
            {
                "name": "Walid D Fakhouri",
                "org": "Department of Diagnostic and Biomedical Sciences, Sciences University of Texas Health Science Center School of Dentistry, Houston, 77054, USA."
            },
            {
                "name": "Ariadne Letra",
                "org": "Department of Diagnostic and Biomedical Sciences, Sciences University of Texas Health Science Center School of Dentistry, Houston, 77054, USA. Ariadne.M.Letra@uth.tmc.edu."
            }
        ],
        "venue": "Scientific reports",
        "year": 2018
    },
    "GnZPGpSb": {
        "id": "GnZPGpSb",
        "title": "Practical Approaches for Whole-Genome Sequence Analysis of Heart- and Blood-Related Traits",
        "abstract": "Whole-genome sequencing (WGS) allows for a comprehensive view of the sequence of the human genome. We present and apply integrated methodologic steps for interrogating WGS data to characterize the genetic architecture of 10 heart- and blood-related traits in a sample of 1,860 African Americans. In order to evaluate the contribution of regulatory and non-protein coding regions of the genome, we conducted aggregate tests of rare variation across the entire genomic landscape using a sliding window, complemented by an annotation-based assessment of the genome using predefined regulatory elements and within the first intron of all genes. These tests were performed treating all variants equally as well as with individual variants weighted by a measure of predicted functional consequence. Significant findings were assessed in 1,705 individuals of European ancestry. After these steps, we identified and replicated components of the genomic landscape significantly associated with heart- and blood-related traits. For two traits, lipoprotein(a) levels and neutrophil count, aggregate tests of low-frequency and rare variation were significantly associated across multiple motifs. For a third trait, cardiac troponin T, investigation of regulatory domains identified a locus on chromosome 9. These practical approaches for WGS analysis led to the identification of informative genomic regions and also showed that defined non-coding regions, such as first introns of genes and regulatory domains, are associated with important risk factor phenotypes. This study illustrates the tractable nature of WGS data and outlines an approach for characterizing the genetic architecture of complex traits.",
        "keywords": "",
        "authors": [
            {
                "name": "Alanna C. Morrison",
                "org": "Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA"
            },
            {
                "name": "Zhuoyi Huang",
                "org": ""
            },
            {
                "name": "Bing Yu",
                "org": "Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA"
            },
            {
                "name": "Ginger A. Metcalf",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA"
            },
            {
                "name": "Christie M. Ballantyne",
                "org": "Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Christie M. Ballantyne",
                "org": "Section of Cardiovascular Research, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Josef Coresh",
                "org": "Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21287, USA"
            },
            {
                "name": "Fuli Yu",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Donna M. Muzny",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Elena Feofanova",
                "org": ""
            },
            {
                "name": "Navin Rustagi",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Richard A. Gibbs",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA"
            }
        ],
        "venue": "American Journal of Human Genetics",
        "year": 2017
    },
    "ZxRBB1Es": {
        "id": "ZxRBB1Es",
        "title": "Genetic variants in microRNA genes and targets associated with cardiovascular disease risk factors in the African-American population.",
        "abstract": "The purpose of this study is to identify microRNA (miRNA) related polymorphism, including single nucleotide variants (SNVs) in mature miRNA-encoding sequences or in miRNA-target sites, and their association with cardiovascular disease (CVD) risk factors in African-American population. To achieve our objective, we examined 1900 African-Americans from the Atherosclerosis Risk in Communities study using SNVs identified from whole-genome sequencing data. A total of 971 SNVs found in 726 different mature miRNA-encoding sequences and 16,057 SNVs found in the three prime untranslated region (3'UTR) of 3647 protein-coding genes were identified and interrogated their associations with 17 CVD risk factors. Using single-variant-based approach, we found 5 SNVs in miRNA-encoding sequences to be associated with serum Lipoprotein(a) [Lp(a)], high-density lipoprotein (HDL) or triglycerides, and 2 SNVs in miRNA-target sites to be associated with Lp(a) and HDL, all with false discovery rates of 5%. Using a gene-based approach, we identified 3 pairs of associations between gene NSD1 and platelet count, gene HSPA4L and cardiac troponin T, and gene AHSA2 and magnesium. We successfully validated the association between a variant specific to African-American population, NR_039880.1:n.18A>C, in mature hsa-miR-4727-5p encoding sequence and serum HDL level in an independent sample of 2135 African-Americans. Our study provided candidate miRNAs and their targets for further investigation of their potential contribution to ethnic disparities in CVD risk factors.",
        "keywords": "",
        "authors": [
            {
                "name": "Chang Li",
                "org": "Human Genetics Center and Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA."
            },
            {
                "name": "Megan L Grove",
                "org": "Human Genetics Center and Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA."
            },
            {
                "name": "Bing Yu",
                "org": "Human Genetics Center and Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA."
            },
            {
                "name": "Barbara C Jones",
                "org": "Human Genetics Center and Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA."
            },
            {
                "name": "Alanna Morrison",
                "org": "Human Genetics Center and Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA."
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. Eric.Boerwinkle@uth.tmc.edu."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Center for Precision Health, The University of Texas Health Science Center at Houston, Houston, TX, USA. Xiaoming.Liu@uth.tmc.edu."
            }
        ],
        "venue": "Human genetics",
        "year": 2017
    },
    "ziuWxxKZ": {
        "id": "ziuWxxKZ",
        "title": "Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.",
        "abstract": "In this large whole-exome sequencing study of severe statin-related muscle injury conducted to date, we did not find evidence that rare coding variants are responsible for this adverse drug reaction. Larger sample sizes would be required to identify rare variants with small effects, but it is unclear whether such findings would be clinically actionable.",
        "keywords": "",
        "authors": [
            {
                "name": "James S Floyd",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Katarzyna M Bloch",
                "org": "MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "Jennifer A Brody",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Cyrielle Maroteau",
                "org": "Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom."
            },
            {
                "name": "Moneeza K Siddiqui",
                "org": "Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom."
            },
            {
                "name": "Richard Gregory",
                "org": "Functional and Comparative Genomics, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "Daniel F Carr",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Mariam Molokhia",
                "org": "School of Population Health and Environmental Sciences, London, United Kingdom."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, University of Texas Health Science Center, Houston, United States of America."
            },
            {
                "name": "Joshua C Bis",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Ammar Ahmed",
                "org": "Medical School, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "Xuan Liu",
                "org": "Functional and Comparative Genomics, Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "P\u00e4r Hallberg",
                "org": "Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala University Hospital, Uppsala, Sweden."
            },
            {
                "name": "Qun-Ying Yue",
                "org": "Medical Products Agency, Uppsala, Sweden."
            },
            {
                "name": "Patrik K E Magnusson",
                "org": "Swedish Twin Registry, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden."
            },
            {
                "name": "Diane Brisson",
                "org": "Clinical Lipidology and Rare Lipid Disorders Unit, Department of Medicine, Universit\u00e9 de Montr\u00e9al Community Gene Medicine Center, Lipid Clinic Chicoutimi Hospital and ECOGENE-21 Clinical and Translational Research Center, Chicoutimi, Quebec, Canada."
            },
            {
                "name": "Kerri L Wiggins",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Alanna C Morrison",
                "org": "Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America."
            },
            {
                "name": "Etienne Khoury",
                "org": "Clinical Lipidology and Rare Lipid Disorders Unit, Department of Medicine, Universit\u00e9 de Montr\u00e9al Community Gene Medicine Center, Lipid Clinic Chicoutimi Hospital and ECOGENE-21 Clinical and Translational Research Center, Chicoutimi, Quebec, Canada."
            },
            {
                "name": "Paul McKeigue",
                "org": "Usher Institute of Population Health Sciences and Informatics, University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom."
            },
            {
                "name": "Bruno H Stricker",
                "org": "Department of Epidemiology, Erasmus Medical Centre, Rotterdam, the Netherlands."
            },
            {
                "name": "Maryse Lapeyre-Mestre",
                "org": "Paul Sabatier University - Toulouse III, UPS Toulouse, Laboratoire de Pharmacologie Medicale et Clinique, Toulouse, France."
            },
            {
                "name": "Susan R Heckbert",
                "org": "Department of Epidemiology, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Arlene M Gallagher",
                "org": "Clinical Practice Research Datalink (CPRD) Medicines and Healthcare Products Regulatory Agency, London, United Kingdom."
            },
            {
                "name": "Hector Chinoy",
                "org": "Rheumatology Department, Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Salford, United Kingdom."
            },
            {
                "name": "Richard A Gibbs",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, United States of America."
            },
            {
                "name": "Emmanuelle Bondon-Guitton",
                "org": "Centre Hospitalier Universitaire de Toulouse, CHU Toulouse, Centre de Pharmacovigilance, Toulouse, France."
            },
            {
                "name": "Russell Tracy",
                "org": "Departments of Pathology & Laboratory Medicine and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, Vermont, United States of America."
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America."
            },
            {
                "name": "Daniel Gaudet",
                "org": "Clinical Lipidology and Rare Lipid Disorders Unit, Department of Medicine, Universit\u00e9 de Montr\u00e9al Community Gene Medicine Center, Lipid Clinic Chicoutimi Hospital and ECOGENE-21 Clinical and Translational Research Center, Chicoutimi, Quebec, Canada."
            },
            {
                "name": "Anita Conforti",
                "org": "U.O. Farmacologia, Policlinico \"Gb Rossi\", Verona, Italy."
            },
            {
                "name": "Tjeerd van Staa",
                "org": "Division of Informatics, Imaging & Data Sciences, University of Manchester, Manchester, United Kingdom."
            },
            {
                "name": "Colleen M Sitlani",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Kenneth M Rice",
                "org": "Department of Biostatistics, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Anke-Hilse Maitland-van der Zee",
                "org": "Respiratory Medicine/Pediatric Respiratory Medicine, AMC, Amsterdam, the Netherlands."
            },
            {
                "name": "Mia Wadelius",
                "org": "Medical School, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "Andrew P Morris",
                "org": "Department of Biostatistics, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "Munir Pirmohamed",
                "org": "MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom."
            },
            {
                "name": "Colin A N Palmer",
                "org": "Division of Molecular and Clinical Medicine, University of Dundee, Dundee, United Kingdom."
            },
            {
                "name": "Bruce M Psaty",
                "org": "Department of Medicine, University of Washington, Seattle, Washington, United States of America."
            },
            {
                "name": "Ana Alfirevic",
                "org": "MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom."
            }
        ],
        "venue": "PloS one",
        "year": 2019
    },
    "QHKLt2Hb": {
        "id": "QHKLt2Hb",
        "title": "Whole genome sequence analysis of serum amino acid levels",
        "abstract": "BackgroundBlood levels of amino acids are important biomarkers of disease and are influenced by synthesis, protein degradation, and gene\u2013environment interactions. Whole genome sequence analysis of amino acid levels may establish a paradigm for analyzing quantitative risk factors.",
        "keywords": "",
        "authors": [
            {
                "name": "Bing Yu",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Paul S. de Vries",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Ginger A. Metcalf",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, USA"
            },
            {
                "name": "Zhe Wang",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Elena Feofanova",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Donna M. Muzny",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, USA"
            },
            {
                "name": "Lynne E. Wagenknecht",
                "org": "Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, USA"
            },
            {
                "name": "Richard A. Gibbs",
                "org": "Human Genome Sequencing Center, Baylor College of Medicine, Houston, USA"
            },
            {
                "name": "Alanna C. Morrison",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            },
            {
                "name": "Eric Boerwinkle",
                "org": "Human Genetics Center, University of Texas Health Science Center at Houston, Houston, USA"
            }
        ],
        "venue": "Genome Biology",
        "year": 2016
    },
    "3kn73xyi": {
        "id": "3kn73xyi",
        "title": "Sequencing of 2 Subclinical Atherosclerosis Candidate Regions in 3669 Individuals",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Joshua C. Bis",
                "org": ""
            },
            {
                "name": "Charles C. White",
                "org": ""
            },
            {
                "name": "Nora Franceschini",
                "org": ""
            },
            {
                "name": "Jennifer A. Brody",
                "org": ""
            },
            {
                "name": "Xiaoling Zhang",
                "org": ""
            },
            {
                "name": "Donna M. Muzny",
                "org": ""
            },
            {
                "name": "Jireh Santibanez",
                "org": ""
            },
            {
                "name": "Richard A. Gibbs",
                "org": ""
            },
            {
                "name": "Xiaoming Liu",
                "org": ""
            },
            {
                "name": "Honghuang Lin",
                "org": ""
            },
            {
                "name": "Eric Boerwinkle",
                "org": ""
            },
            {
                "name": "Bruce M. Psaty",
                "org": ""
            },
            {
                "name": "Kari E. North",
                "org": ""
            },
            {
                "name": "L. Adrienne Cupples",
                "org": ""
            },
            {
                "name": "Christopher J. O\u2019Donnell",
                "org": ""
            }
        ],
        "venue": "Circulation-cardiovascular Genetics",
        "year": 2014
    },
    "hSpvNvqd": {
        "id": "hSpvNvqd",
        "title": "Unbiased association and expression studies identify novel genes for tooth development",
        "abstract": "Previously reported co-occurrence of colorectal cancer (CRC) and tooth agenesis (TA) and the overlap in disease-associated gene variants suggest involvement of similar molecular pathways. In this study, we took an unbiased approach and tested genome-wide significant CRC-associated variants for association with isolated TA. Thirty single nucleotide variants (SNVs) in CRC-predisposing genes/loci were genotyped in a discovery dataset composed of 440 individuals with and without isolated TA. Genome-wide significant associations were found between TA and DUSP10 rs6687758 (P=1.25 x 10-9) and ATF1 rs11169552 (P=4.36 x 10-10), with strong association found with CASC8 rs10505477 (P=8.2 x 10-5). Additional CRC marker haplotypes were also significantly associated with TA (Pu003c0.0002). Genotyping an independent dataset consisting of 52 cases with TA and 427 controls confirmed the association with CASC8.Atf1 and Dusp10 expression was detected in the mouse developing teeth from early bud stages to the formation of the complete tooth, suggesting a potential role for these genes and their encoded proteins in tooth development. Our findings suggest Atf1 and Dusp10 as new tooth development genes, while having a role in colorectal cancer. While their individual contributions in tooth development remain to be elucidated, these genes may be considered additional candidates to be tested in future human genetic studies.",
        "keywords": "",
        "authors": [
            {
                "name": "Meredith A. Williams",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            },
            {
                "name": "Claudia Cristina Biguetti",
                "org": "University of Sao Paulo Bauru Dental School;"
            },
            {
                "name": "Miguel Romero-Bustillos",
                "org": "University of Iowa;"
            },
            {
                "name": "Kanwal Maheshwari",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            },
            {
                "name": "Nuriye Dinckan",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            },
            {
                "name": "Franco Cavalla",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            },
            {
                "name": "Xiaoming Liu",
                "org": "University of Texas Health Science Center at Houston School of Public Health;"
            },
            {
                "name": "Renato Menezes Silva",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            },
            {
                "name": "Sercan Akyalcin",
                "org": "Tufts University School of Dental Medicine;"
            },
            {
                "name": "Zehra Oya Uyguner",
                "org": "Istanbul University;"
            },
            {
                "name": "Alexandre R. Vieira",
                "org": "University of Pittsburgh School of Dental Medicine"
            },
            {
                "name": "Brad A. Amendt",
                "org": "University of Iowa;"
            },
            {
                "name": "Walid D Fakhrouri",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            },
            {
                "name": "Ariadne Letra",
                "org": "University of Texas Health Science Center at Houston School of Dentistry;"
            }
        ],
        "venue": "bioRxiv",
        "year": 2017
    },
    "8Nbx7ulm": {
        "id": "8Nbx7ulm",
        "title": "iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing cancer driver genes in personal genomes",
        "abstract": "All cancers arise as a result of the acquisition of somatic mutations that drive the disease progression. A number of computational tools have been developed to identify driver genes for a specific cancer from a group of cancer samples. However, it remains a challenge to identify driver mutations/genes for an individual patient and design drug therapies. We developed iCAGES, a novel statistical framework to rapidly analyze patient-specific cancer genomic data, prioritize personalized cancer driver events and predict personalized therapies. iCAGES includes three consecutive layers: the first layer integrates contributions from coding, non-coding and structural variations to infer driver variants. For coding mutations, we developed a radial support vector machine using manually curated mutations to predict their driver potential. The second layer identifies driver genes, by using information from the first layer and integrating prior biological knowledge on gene-gene and gene-phenotype networks. The third layer prioritizes personalized drug treatment, by classifying potential driver genes into different categories and querying drug-gene databases. Compared to currently available tools, iCAGES achieves better performance by correctly classifying point coding driver mutations (AUC=0.97, 95% CI: 0.97-0.97, significantly better than the second best tool with P=0.01) and genes (AUC=0.93, 95% CI: 0.93-0.94, significantly better than MutSigCV with Pu003c1X10-15). We also illustrated two examples where iCAGES correctly nominated two targeted drugs for two advanced cancer patients with exceptional response, based on their somatic mutation profiles. iCAGES leverages personal genomic information and prior biological knowledge, effectively identifies cancer driver genes and predicts treatment strategies. iCAGES is available at http://icages.usc.edu.",
        "keywords": "",
        "authors": [
            {
                "name": "Chengliang Dong",
                "org": "University of Southern California;"
            },
            {
                "name": "Hui Yang",
                "org": "University of Southern California;"
            },
            {
                "name": "Zeyu He",
                "org": "New York University;"
            },
            {
                "name": "Xiaoming Liu",
                "org": "The University of Texas Health Science Center at Houston"
            },
            {
                "name": "Kai Wang",
                "org": "University of Southern California;"
            }
        ],
        "venue": "bioRxiv",
        "year": 2015
    },
    "Ob4q1etN": {
        "id": "Ob4q1etN",
        "title": "In Silico Prediction of Deleteriousness for Nonsynonymous and Splice-Altering Single Nucleotide Variants in the Human Genome.",
        "abstract": "In silico prediction methods have increasingly been valuable and popular in molecular biology, especially in human genetics, for deleteriousness prediction to filter and prioritize huge amounts of DNA variation identified by sequencing human genomes. There is a rich collection of available methods developed upon different levels/aspects of knowledge about how DNA variations affect gene expression. Given the fact that their predictions are not always consistent or even opposite of what was expected, using consensus prediction or majority vote among these methods is preferred to trusting any single one. Because querying different databases for different methods is both tedious and time-consuming for such big data sets, one database integrating predictions from multiple databases can facilitate the process. In this chapter, we describe the general steps of obtaining comprehensive predictions and annotations for large numbers of variants from dbNSFP, the first and probably the most widely used database of its kind.",
        "keywords": [
            "Database",
            "Functional prediction",
            "In silico",
            "Nonsynonymous",
            "Protocol",
            "Single nucleotide variant",
            "Splice site",
            "dbNSFP",
            "dbscSNV"
        ],
        "authors": [
            {
                "name": "Xueqiu Jian",
                "org": "Center for Human Genetics, Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Pressler St, E529, Houston, TX, 77030, USA. xiaoming.liu@uth.tmc.edu."
            }
        ],
        "venue": "Methods in molecular biology (Clifton, N.J.)",
        "year": 2017
    },
    "kgFzHgRk": {
        "id": "kgFzHgRk",
        "title": "Investigation of multi-trait associations using pathway-based analysis of GWAS summary statistics.",
        "abstract": "Our study revealed that risk variants for 25 different traits aggregated in particular biological pathways and that these pathways were frequently shared among traits. Our results confirmed known mechanisms and also suggested several novel insights into the etiology of multi-traits.",
        "keywords": [
            "Cross-trait association",
            "GWAS",
            "Multi-dimensional scaling",
            "Pathway enrichment analysis",
            "Pleiotropy abbreviations",
            "Summary statistics"
        ],
        "authors": [
            {
                "name": "Guangsheng Pei",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St. Suite 820, Houston, TX, 77030, USA."
            },
            {
                "name": "Hua Sun",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St. Suite 820, Houston, TX, 77030, USA."
            },
            {
                "name": "Yulin Dai",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St. Suite 820, Houston, TX, 77030, USA."
            },
            {
                "name": "Xiaoming Liu",
                "org": "Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA."
            },
            {
                "name": "Zhongming Zhao",
                "org": "Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 37203, USA. zhongming.zhao@uth.tmc.edu."
            },
            {
                "name": "Peilin Jia",
                "org": "Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, 7000 Fannin St. Suite 820, Houston, TX, 77030, USA. peilin.jia@uth.tmc.edu."
            }
        ],
        "venue": "BMC genomics",
        "year": 2019
    },
    "hkEAQ4bs": {
        "id": "hkEAQ4bs",
        "title": "Assessment of the genetic connectivity between farmed and wild populations of Undaria pinnatifida (Phaeophyceae) in a representative traditional farming region of China by using newly developed microsatellite markers",
        "abstract": "Undaria pinnatifida is an important economic macroalga extensively farmed in East Asia. Wild individuals of U. pinnatifida, which can be easily discriminated due to their peculiar morphology, are usually observed to occur on the cultivation infrastructure adjacent to the farmed ones in the farming area. The genetic connectivity between the wild and farmed populations, however, remains unidentified. In this study, 30 informative microsatellite markers were developed and characterized through the next-generation sequencing technology. Ten of them were used to analyze the genetic structure of wild and farmed populations sampled from a representative Undaria farm in Lushun (latitude: 38\u00b0 47\u2032 N) from 2015 to 2017, with two wild populations from Qingdao (36\u00b0 03\u2032 N) and Gouqi Island (30\u00b0 42\u2032 N) as controls. The dendrogram clearly separated farmed populations from wild ones by large genetic distance. The Bayesian model-based structure analysis grouped all the populations into five clusters. The wild individuals on the farm were found to contain relatively a large proportion of membership originated from farmed ones. In contrast, nearly no wild membership was detected in the farmed populations. These results imply asymmetric gene flow between farmed and wild populations and indicate that the pedigree of farmed cultivars has been well maintained through artificial control in the current seedling production system. Efforts should be made to popularize this system for the benefits of sustainable utilization of cultivars in Undaria farming.",
        "keywords": "",
        "authors": [
            {
                "name": "Tifeng Shan",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Shaojun Pang",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Xuemei Wang",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Jing Li",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Li Su",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2018
    },
    "RJjE2r0O": {
        "id": "RJjE2r0O",
        "title": "Construction of a high-density genetic map and mapping of a sex-linked locus for the brown alga Undaria pinnatifida (Phaeophyceae) based on large scale marker development by specific length amplified fragment (SLAF) sequencing",
        "abstract": "",
        "keywords": [
            "microarrays",
            "proteomics"
        ],
        "authors": [
            {
                "name": "tifeng shan",
                "org": "chinese academy of sciences"
            },
            {
                "name": "shaojun pang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jing li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "xia li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "li su",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "BMC Genomics",
        "year": 2015
    },
    "CSce7qev": {
        "id": "CSce7qev",
        "title": "Isolation and characterization of eight novel microsatellite loci from the brown alga Sargassum horneri",
        "abstract": "Abstract Sargassum horneri (Turner) C. Agardh is one principal member of the ecologically important brown seaweeds that form submarine forests in the northwest Pacific coasts. However, no microsatellite marker has been available for S. horneri to our knowledge. In this study, eight polymorphic microsatellite loci were isolated for the first time from S. horneri using the protocol of fast isolation by AFLP of sequences containing repeats (FIASCO). The characteristics of these microsatellites were determined in a sample of 34 individuals of S. horneri. The number of the alleles per locus ranged from 2 to 5 (average 3.5). Mean observed and expected heterozygosity were 0.441 and 0.416, respectively. These polymorphic markers will provide a useful tool for further studies of population and conservation genetics in this species.",
        "keywords": [
            "Sargassum horneri",
            "Brown alga",
            "Microsatellite",
            "Genetic diversity",
            "Population genetics",
            "Phaeophyceae"
        ],
        "authors": [
            {
                "name": "Tifeng Shan",
                "org": "Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, People\u2019s Republic of China"
            },
            {
                "name": "Shaojun Pang",
                "org": "Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, People\u2019s Republic of China"
            },
            {
                "name": "Jing Li",
                "org": "Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, People\u2019s Republic of China ; Graduate University of Chinese Academy of Science, Beijing, 100049, People\u2019s Republic of China"
            },
            {
                "name": "Li Su",
                "org": "Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, People\u2019s Republic of China ; Graduate University of Chinese Academy of Science, Beijing, 100049, People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2015
    },
    "Gi3anU50": {
        "id": "Gi3anU50",
        "title": "De novo transcriptome analysis of the gametophyte of Undaria pinnatifida (Phaeophyceae)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ti feng shan",
                "org": "chinese academy of sciences"
            },
            {
                "name": "s j pang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jing li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "xia li",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2014
    },
    "Qw8NslLW": {
        "id": "Qw8NslLW",
        "title": "Complete mitochondrial genome of the brown alga Sargassum horneri (Sargassaceae, Phaeophyceae): genome organization and phylogenetic analyses",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "feng liu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "shaojun pang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "xia li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jing li",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2014
    },
    "GHPaqFfj": {
        "id": "GHPaqFfj",
        "title": "Selection of reference genes for real-time RT-PCR normalization in brown alga Undaria pinnatifida",
        "abstract": "Quantitative real-time PCR (qRT-PCR) has become widely used method for detecting gene expression of an organism at different developmental stages or under various stressful environmental conditions. Finding reference genes is a prerequisite in this process. In this research, we investigated the expression stability of eight candidate genes in the brown alga Undaria pinnatifida, including EF1\u03b1 (elongation factor 1-alpha), eEF1\u03b2 (eukaryotic elongation factor-1 B beta), RPL35 (60S ribosomal protein L35-3), GAPDH (glyceraldehyde-3-phosphatedehydrogenase), RPS17 (40S ribosomal protein S17), LHCP (light-harvesting complex protein), ribH (6,7-dimethyl-8-ribityllumazine synthase), and ilvC (ketol-acid reductoisomerase). The haploid male and female gametophytes at different stages, as well as the diploid sporophytes treated with different abiotic factors were analyzed by geNorm and NormFinder software. It was found that eEF1\u03b2 and ribH could be used as the most stable reference genes in studies of gender or developmental gene expression in the gametophytes. As for the detection of gene expression in the sporophytes, eEF1\u03b2 and ribH were recommended as the most suitable reference genes for irradiance treatment, eEF1\u03b2 and RPL35 for temperature treatment, while EF1\u03b1 and LHCP for nutrition treatment. These results will enable us to go further for quantifying gene expression study at transcript level in U. pinnatifida.",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Li",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Haishu Huang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Tifeng Shan",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Shaojun Pang",
                "org": "Chinese Academy of Sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2018
    },
    "5qZ7B96j": {
        "id": "5qZ7B96j",
        "title": "Isolation and characterization of eight novel microsatellite loci from the brown alga Sargassum horneri",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tifeng shan",
                "org": "chinese academy of sciences"
            },
            {
                "name": "shaojun pang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jing li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "li su",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2015
    },
    "OELLvSS0": {
        "id": "OELLvSS0",
        "title": "Biological identification and determination of optimum growth conditions for four species of Navicula",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaobo zhao",
                "org": "chinese academy of sciences"
            },
            {
                "name": "shaojun pang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "feng liu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "tifeng shan",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jing li",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Acta Oceanologica Sinica",
        "year": 2014
    },
    "dsq5Igig": {
        "id": "dsq5Igig",
        "title": "Zoospore-derived monoecious gametophytes in Undaria pinnatifida (Phaeophyceae)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shaojun pang",
                "org": ""
            },
            {
                "name": "tifeng shan",
                "org": ""
            },
            {
                "name": "feng liu",
                "org": ""
            },
            {
                "name": "suqin gao",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Oceanology and Limnology",
        "year": 2013
    },
    "cPllAKDc": {
        "id": "cPllAKDc",
        "title": "Intraspecific crossing of Saccharina japonica using distantly related unialgal gametophytes benefits kelp farming by improving blade quality and productivity at Sanggou Bay, China",
        "abstract": "When cultivating the kelp, Saccharina japonica, in China, one of the causes leading to degeneration in blade quality and productivity has been thought to be inbreeding caused by the use of limited numbers of sorus-bearing individuals that are continuously used over generations to produce large numbers of offspring. One of the effective solutions is to use intraspecific hybrid vigor to produce new cultivars or to recreate the original agronomic features of the older cultivars. This study produced a sporophytic B013 (cultivar code) by crossing a pair of distantly related unialgal male and female gametophyte clones. The male was isolated from an individual collected from a farmed population at Rongcheng, China, while the female came from a Korean wild individual sporophyte. In comparison with four controls, the B013 sporophytic offspring demonstrated excellent blade quality (entirely dark green in the dried product), high alginate (29.7-32.9 %) and iodine (0.29-0.31 mg g(-1)) contents in the dried product, the lowest fresh weight/sun-dried weight (FW/DW) ratio and the smallest coefficients of variation for total length (7.4 %), width (6.9 %), and biomass output (14.6 %). In addition, this cultivar remained in a vegetative state from June to August, greatly reducing the biomass loss during the hot summer season. In comparison with seeding zoospores for seedling production, seeding a selected pair of unialgal gametophytes had apparent advantages in effectively preventing inbreeding depression, which gave rise to a uniformed product and provided new cultivars for large-scale farming.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiao Bo Zhao",
                "org": "Shandong Peanut Research Institute"
            },
            {
                "name": "Shaojun Pang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Feng Liu",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Ti Feng Shan",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Jing Li",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Su Qin Gao",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Hyung Geun Kim",
                "org": "Gangneung-Wonju National University"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2016
    },
    "wbHdkGqc": {
        "id": "wbHdkGqc",
        "title": "Analyses of the genetic structure of Sargassum horneri in the Yellow Sea: implications of the temporal and spatial relations among floating and benthic populations",
        "abstract": "Sargassum horneri is one of the most common seaweeds in China growing on solid substrates in the sublittoral zones along the Chinese coast. Large-scale drifting biomass of S. horneri has been reported in the Yellow Sea since 2010. Huge amount of the stranded biomass of this alga on the cultivation rafts of Pyropia yezoensis has drawn wide attention after damaging the local Pyropia farming industry. The original sources of the drifting biomass in the Yellow Sea remain unknown. In this study, 16 populations including three benthic and 13 drifting ones were sampled from the Yellow Sea and the East China Sea. Results of microsatellite analyses revealed that there were significant genetic differentiations among most of the investigated populations. Cluster analysis demonstrated that the drifting individuals from the same year, rather than from the same sampling locations, were clustered together. The existence of marked admixture in six populations also implies that the same drifting population could be of different origins. These results provide evidence suggesting that the drifting populations, in particular the populations occurring in different years, originated from multiple sources. Satellite imagery observation combined with genetic analyses of more benthic and drifting populations in the future are expected to elucidate, on a clearer level, the exact locations of the origin of the drifting populations.",
        "keywords": "",
        "authors": [
            {
                "name": "Li Su",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Tifeng Shan",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Shaojun Pang",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            },
            {
                "name": "Jing Li",
                "org": "Institute of Oceanology, Chinese Academy of Sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2018
    },
    "3qEiqAZZ": {
        "id": "3qEiqAZZ",
        "title": "Breeding of an elite cultivar Haibao No. 1 of Undaria pinnatifida (Phaeophyceae) through gametophyte clone crossing and consecutive selection",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ti feng shan",
                "org": "chinese academy of sciences"
            },
            {
                "name": "s j pang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jing li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "su qin gao",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2015
    },
    "rQ2KuhST": {
        "id": "rQ2KuhST",
        "title": "Genetic analysis of a recently established Undaria pinnatifida (Laminariales: Alariaceae) population in the northern Wadden Sea reveals close proximity between drifting thalli and the attached population",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tifeng Shan",
                "org": "Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"
            },
            {
                "name": "Shaojun Pang",
                "org": "Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"
            },
            {
                "name": "Xuemei Wang",
                "org": "Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"
            },
            {
                "name": "Jing Li",
                "org": "Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"
            },
            {
                "name": "Li Su",
                "org": "Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China"
            },
            {
                "name": "Jessica Schiller",
                "org": "Bremen Marine Ecology (BreMarE), Marine Botany, University of Bremen, Leobener Str. 3, 28359 Bremen, Germany"
            },
            {
                "name": "Dagmar Lackschewitz",
                "org": "Alfred Wegener Institute, Wadden Sea Station, 25992 List/Sylt, Germany"
            },
            {
                "name": "Jason M. Hall-Spencer",
                "org": "University of Plymouth, School of Biological and Marine Sciences, Plymouth,UK"
            },
            {
                "name": "Jason M. Hall-Spencer",
                "org": "University of Plymouth, School of Biological and Marine Sciences, Plymouth,UK"
            },
            {
                "name": "Kai Bischof",
                "org": "Bremen Marine Ecology (BreMarE), Marine Botany, University of Bremen, Leobener Str. 3, 28359 Bremen, Germany"
            }
        ],
        "venue": "European Journal of Phycology",
        "year": 2019
    },
    "HR7WcFop": {
        "id": "HR7WcFop",
        "title": "Existence of an intact male life cycle offers a novel way in pure-line crossbreeding in the brown alga Undaria pinnatifida",
        "abstract": "Hermaphroditic gametophyte production and an intact male life cycle were investigated in Undaria pinnatifida. Zoospore-derived hermaphroditic gametophyte could give rise to male sporophytes which showed the same morphological appearance but with smaller biomass than normal cultivated sporophytes. Male sporophytes were shown to discharge only male zoospores. In this investigation, male spores derived from the male sporophytes and female spores derived from female parthenosporophytes were crossed to produce the hybrid sporophytic offspring. The latter contained both alleles of homozygous parental sporophytes when analyzed by use of eight polymorphic microsatellite markers, further confirming the success of cross. Thus, line crossing by use of unisexual sporophytes will be expected to replace unisexual gametophyte line crossing in breeding practice in the future in this commercially farmed seaweed.",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Li",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Shaojun Pang",
                "org": "Chinese Academy of Sciences"
            },
            {
                "name": "Tifeng Shan",
                "org": "Chinese Academy of Sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2017
    },
    "mIWgR1Va": {
        "authors": [
            {
                "name": "Qinghua Geng",
                "org": "Shenyang Entry-Exit Inspection and Quarantine Bureau"
            },
            {
                "name": "Jianfeng Ding",
                "org": "Dalian Ocean University"
            },
            {
                "name": "Li Jiang",
                "org": "Shenyang Entry-Exit Inspection and Quarantine Bureau"
            },
            {
                "name": "Yin Wu",
                "org": "Dalian Ocean University"
            },
            {
                "name": "Pengyun Bao",
                "org": "Dalian Ocean University"
            }
        ],
        "title": "Subacute toxicity of two polyoxyethylene-type nonionic surfactants on antioxidative defense system in the zebrafish Danio rerio",
        "abstract": "The main purpose of this study is to study the toxic effect of short-term nonionic surfactants dibenzyl phenol polyoxyethylene ether (BP) and fatty alcohol polyoxyethylene ether (AEO) exposure on the zebra fish Danio rerio. After treatment with different concentrations (0 mg/L, 0.25 mg/L, 0.5 mg/L, 1 mg/L, 2 mg/L) of BP and AEO for 30 days, the catalase (CAT) and superoxide dismutase (SOD) activities increased while the glutathione (GSH) content decreased in liver tissue of experimental zebrafish, and no significant different changes were observed in levels of malondialdehyde (MDA) and total antioxidant capacity (T-AOC). These results indicated the nonionic surfactants BP and AEO had potential toxic effects on zabrafish antioxidant defense system, and supported the view that a relationship exists between pollution and immunomodulation in aquatic organisms. \u00a9 Sila Science. All Rights Reserved.",
        "keywords": [
            "Antioxidative defense system",
            "Lipid peroxidation",
            "Polyoxyethylene-type nonionic surfactants",
            "Subacute toxicity"
        ],
        "venue": "Energy Education Science and Technology Part A: Energy Science and Research",
        "year": 2014,
        "id": "mIWgR1Va"
    },
    "GiHVPpNM": {
        "authors": [
            {
                "name": "Mingyu Gao",
                "org": ""
            },
            {
                "name": "Da Chen",
                "org": ""
            },
            {
                "name": "Pan Din",
                "org": ""
            },
            {
                "name": "Zhiwei He",
                "org": ""
            },
            {
                "name": "Zhanxiong Wu",
                "org": ""
            },
            {
                "name": "Yuanyuan Liu",
                "org": ""
            }
        ],
        "title": "A fixed-distance Cartesian path planning algorithm for 6-DOF industrial robots",
        "abstract": "When an industrial robot moves, it needs a suitable trajectory to avoid collisions with other objects, to pass a predefined point in spatial coordinates and to achieve fast and accurate motion. Trajectory planning algorithms can be divided into two categories: the joint space-oriented and the Cartesian coordinate space-oriented. This paper presents a quick and efficient trajectory planning algorithm based on the Cartesian coordinates for 6-DOF industrial robots. By the simulation in MATLAB and verification on 6-DOF industrial robot platform, the fixed-distance algorithm can achieve speed control, position control and orientation control of the 6-DOF industrial robot. Compared with traditional algorithms, the portability, speed and control precision have gotten greatly improved.",
        "keywords": [
            "Cartesian coordinate system",
            "fixed-distance",
            "Industrial robot",
            "Trajectory planning"
        ],
        "venue": "IEEE International Symposium on Industrial Electronics",
        "year": 2015,
        "id": "GiHVPpNM"
    },
    "NCoMysFi": {
        "authors": [
            {
                "name": "Guojin Ma",
                "org": "Department of Electronic and Information Engineering"
            },
            {
                "name": "Changhong Yu",
                "org": "Department of Electronic and Information Engineering"
            },
            {
                "name": "Zhiwei He",
                "org": "Department of Electronic and Information Engineering"
            },
            {
                "name": "Mingyu Gao",
                "org": "Department of Electronic and Information Engineering"
            },
            {
                "name": "Yuanyuan Liu",
                "org": "Department of Electronic and Information Engineering"
            },
            {
                "name": "Wenhui Chen",
                "org": "Department of Electronic and Information Engineering"
            }
        ],
        "title": "Estimation of Li-ion battery SOH using Fletcher-Reeves based ANFIS",
        "abstract": "With the wide application of batteries, the battery state of health (SOH) is increasingly concerned by people. The battery SOH reflects its ability to store charge and plays a key role in electric power systems. This paper proposes an adaptive neural fuzzy inference system (ANFIS) based method to estimate the battery SOH. The main steps of the proposed method include model creating, model training and SOH estimation. The constant current charging time, the voltage drop at the beginning of discharge and the released energy within a certain depth of discharge are used as the inputs for the model training. Since the basic ANFIS algorithm has large estimation errors and the model trains slowly, A Fletcher-Reeves based method is proposed to improve the basic ANFIS. The trained model is then used for the estimation of the SOH. Experimental results show that the Fletcher-Reeves based ANFIS method is effective and efficient.",
        "keywords": [
            "ANFIS",
            "Fletcher-Reeves",
            "Li-ion battery",
            "state of health"
        ],
        "venue": "IEEE International Symposium on Industrial Electronics",
        "year": 2015,
        "id": "NCoMysFi"
    },
    "VcmRQcU4": {
        "authors": [
            {
                "name": "Zhiwei He",
                "org": ""
            },
            {
                "name": "Mingyu Gao",
                "org": ""
            },
            {
                "name": "Guojin Ma",
                "org": ""
            },
            {
                "name": "Yuanyuan Liu",
                "org": ""
            },
            {
                "name": "Sanxin Chen",
                "org": ""
            }
        ],
        "title": "Online state-of-health estimation of lithium-ion batteries using Dynamic Bayesian Networks",
        "abstract": "Li-ion batteries are widely used in energy storage systems, electric vehicles, communication systems, etc. The State of Health (SOH) of batteries is of great importance to the safety of these systems. This paper presents a novel online method for the estimation of the SOH of Lithium (Li)-ion batteries based on Dynamic Bayesian Networks (DBNs). The structure of the DBN model is built according to the experience of experts, with the state of charges used as hidden states and the terminal voltages used as observations in the DBN. Parameters of the DBN model are learned based on training data collected through Li-ion battery aging experiments. A forward algorithm is applied for the inference of the DBN model in order to estimate the SOH in real-time. Experimental results show that the proposed method is effective and efficient in estimating the SOH of Li-ion batteries. \u00a9 2014 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Battery management system",
            "Dynamic Bayesian Network",
            "Lithium-ion battery",
            "State of health"
        ],
        "venue": "Journal of Power Sources",
        "year": 2014,
        "id": "VcmRQcU4"
    },
    "yQepzhqA": {
        "authors": [
            {
                "name": "Quan Su",
                "org": "College of Electronic and Information Engineering, Hangzhou Dianzi University"
            },
            {
                "name": "Mingyu Gao",
                "org": "College of Electronic and Information Engineering, Hangzhou Dianzi University"
            },
            {
                "name": "Jiye Huang",
                "org": "College of Information Engineering, Hangzhou Dianzi University"
            },
            {
                "name": "Zhiwei He",
                "org": "College of Information Engineering, Hangzhou Dianzi University"
            },
            {
                "name": "Guojin Ma",
                "org": "College of Electronic and Information Engineering, Hangzhou Dianzi University"
            },
            {
                "name": "Yuanyuan Liu",
                "org": "College of Electronic and Information Engineering, Hangzhou Dianzi University"
            }
        ],
        "title": "WC-SWFA algorithm in the application of constant tension control of the yarn",
        "abstract": "The aim of constant tension control of the yarn is to keep the yarn's tension to be consistent during the winding process by controlling the speed of the motor according to the output voltages of the tension sensor. The mechanical structure of spinning machines such as the winding machine makes the fluctuation of the yarn's tension changes rapidly. In this paper, we propose a new tension control algorithm, which is called the weighted curve sliding window filtering algorithm (WC-SWFA). According to this algorithm, the brushless direct current (DC) motor can be controlled to operate stably and efficiently, and the yarns will be shaped well. Theoretical analysis is firstly carried out to verify its effectiveness. Laboratory experiments are then put in force. In the experiments, an arbitrary waveform generator (AFG3252) is used to generate the simulated fluctuation signals of the tension, and an STM32 micro-controller is used to control the rotation of the motor, with the proposed WC-SWFA served as the control algorithm. Practical experiments on the winding machine show that the proposed algorithm works effectively. \u00a9 2014 IEEE.",
        "keywords": [
            "Brushless direct current motor",
            "Curve weighted sliding window filtering algorithm",
            "STM32",
            "Tension sensor"
        ],
        "venue": "IEEE International Symposium on Industrial Electronics",
        "year": 2014,
        "id": "yQepzhqA"
    },
    "t2fzBNSI": {
        "authors": [
            {
                "name": "Zhiwei He",
                "org": ""
            },
            {
                "name": "Mingyu Gao",
                "org": ""
            },
            {
                "name": "Guojin Ma",
                "org": ""
            },
            {
                "name": "Yuanyuan Liu",
                "org": ""
            },
            {
                "name": "Sanxin Chen",
                "org": ""
            }
        ],
        "title": "Online state-of-health estimation of lithium-ion batteries using Dynamic Bayesian Networks",
        "abstract": "Li-ion batteries are widely used in energy storage systems, electric vehicles, communication systems, etc. The State of Health (SOH) of batteries is of great importance to the safety of these systems. This paper presents a novel online method for the estimation of the SOH of Lithium (Li)-ion batteries based on Dynamic Bayesian Networks (DBNs). The structure of the DBN model is built according to the experience of experts, with the state of charges used as hidden states and the terminal voltages used as observations in the DBN. Parameters of the DBN model are learned based on training data collected through Li-ion battery aging experiments. A forward algorithm is applied for the inference of the DBN model in order to estimate the SOH in real-time. Experimental results show that the proposed method is effective and efficient in estimating the SOH of Li-ion batteries. \u00a9 2014 Elsevier B.V. All rights reserved.",
        "keywords": [
            "Battery management system",
            "Dynamic Bayesian Network",
            "Lithium-ion battery",
            "State of health"
        ],
        "venue": "Journal of Power Sources",
        "year": 2014,
        "id": "t2fzBNSI"
    },
    "zWzZFVWq": {
        "id": "zWzZFVWq",
        "title": "The Effect of CFRP Length on the Failure Mode of Strengthened Concrete Beams",
        "abstract": "",
        "keywords": [
            "failure mode",
            "finite element method"
        ],
        "authors": [
            {
                "name": "jun ding",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "xia huang",
                "org": ""
            },
            {
                "name": "song chen",
                "org": ""
            }
        ],
        "venue": "Polymers",
        "year": 2014
    },
    "Ze2qZF8I": {
        "id": "Ze2qZF8I",
        "title": "An empirical examination of the effects of local agro\u2010food quality and safety supervision in China",
        "abstract": "",
        "keywords": [
            "china"
        ],
        "authors": [
            {
                "name": "xiaodong guo",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "xiao yu",
                "org": ""
            },
            {
                "name": "xiaojing liu",
                "org": "ocean university of china"
            },
            {
                "name": "yongzhong qian",
                "org": ""
            },
            {
                "name": "song chen",
                "org": ""
            }
        ],
        "venue": "Quality Assurance and Safety of Crops & Foods",
        "year": 2012
    },
    "gEIamEvB": {
        "id": "gEIamEvB",
        "title": "An empirical examination of the effects of local agro-food quality and safety supervision in China: Effects of local agro-food safety supervision",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "song chen",
                "org": ""
            },
            {
                "name": "yongzhong qian",
                "org": ""
            },
            {
                "name": "xiaojing liu",
                "org": ""
            },
            {
                "name": "xiao yu",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "xiaodong guo",
                "org": ""
            }
        ],
        "venue": "Quality Assurance and Safety of Crops & Foods",
        "year": 2012
    },
    "0Dk2Bahu": {
        "id": "0Dk2Bahu",
        "title": "Assessing the establishment of agro-food control systems based on a relevant officials\u2019 survey in China",
        "abstract": "",
        "keywords": [
            "china"
        ],
        "authors": [
            {
                "name": "lijie yang",
                "org": ""
            },
            {
                "name": "yongzhong qian",
                "org": ""
            },
            {
                "name": "chen chen",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            }
        ],
        "venue": "Food Control",
        "year": 2012
    },
    "utl6hPGl": {
        "id": "utl6hPGl",
        "title": "Laser-cooled HgF as a promising candidate to measure the electric dipole moment of the electron",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhenghai Yang",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Qinning Lin",
                "org": ""
            },
            {
                "name": "Liang Xu",
                "org": ""
            },
            {
                "name": "Hailing Wang",
                "org": ""
            },
            {
                "name": "Tao Yang",
                "org": ""
            },
            {
                "name": "Jianping Yin",
                "org": ""
            }
        ],
        "venue": "Physical Review A",
        "year": 2019
    },
    "MkPAotYt": {
        "id": "MkPAotYt",
        "title": "Theoretical investigation of the HgF radical towards laser cooling and eEDM measurement.",
        "abstract": "In order to realize more sensitive eEDM measurement, it would be worthwhile to find some new laser-cooled molecules with larger internal effective electric field (E$_{eff}$), higher electric polarizability and longer lifetime of the eEDM measurement state. Here we explore the merits of mercuric monofluoride ($^{202}Hg^{19}F$, X$^ 2 {Sigma}_{1/2}$) for its potential of laser cooling and eEDM measurement. We theoretically investigated the electronic, rovibrational and hyperfine structures and verified the highly diagonal Franck-Condon factors (FCFs) of the main transitions by the Rydberg-Klein-Rees inversion (RKR) method and the Morse approximation. Hyperfine manifolds of the X$^ 2 {Sigma}_{1/2} (nu=0$) rotational states were examined with the effective Hamiltonian approach and a feasible sideband modulation scheme was proposed. In order to enhance optical cycling, the microwave remixing method was employed to address all the necessary levels. The Zeeman effect and the hyperfine structure magnetic g factors of the X$^ 2 {Sigma}_{1/2} (nu=0$,$mathit{ N } $=1) state were studied subsequently. Finally, its statistical sensitivities for the eEDM measurement were estimated respectively to be about $9times 10^{-31} ebullet cm $ (the laser cooled transverse beam experiment), $2times 10^{-31} ebullet cm$ (the fountain experiment) and $1times 10^{-32}$ ebullet cm (experiment with trapped cold molecules), indicating that $^{202}Hg^{19}F$ might be another promising eEDM candidate when compared with the most recent ThO result of $d_{ e } = (4.3 pm 3.1_{ stat } pm 2.6_{ syst })times 10^{-30} ebullet cm$ (Nature, 562, 355 (2018)). In addition, the possibility of direct Stark decelerating of the HgF radical was also discussed.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhenghai Yang",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Qinning Lin",
                "org": ""
            },
            {
                "name": "Liang Xu",
                "org": ""
            },
            {
                "name": "Hailing Wang",
                "org": ""
            },
            {
                "name": "Tao Yang",
                "org": ""
            },
            {
                "name": "Jianping Yin",
                "org": ""
            }
        ],
        "venue": "Physical Review A",
        "year": 2018
    },
    "ObSaLEeS": {
        "id": "ObSaLEeS",
        "title": "Survey of prophylactic use of antibiotics for type \u2160 incision surgery",
        "authors": [
            {
                "name": "LIU Jin-yong",
                "org": "The First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "SUN Zeng-xian",
                "org": "The First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "The First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "GAO Shan",
                "org": "The First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            }
        ],
        "venue": "chinese journal of nosocomiology",
        "keywords": [
            "Type \u2160 incision surgery",
            "Prophylaxis",
            "Antibiotics",
            "Rational use"
        ],
        "year": 2013
    },
    "Au1bg8Ej": {
        "id": "Au1bg8Ej",
        "title": "Analysis of Type \u2160Incision Operation Preventive Use Antimicrobial Agents during Perioperative Period",
        "authors": [
            {
                "name": "HAO Zhi-qiang"
            },
            {
                "name": "SUN Zeng-xian"
            },
            {
                "name": "GAO Shan"
            }
        ],
        "venue": "chinese journal of clinical rational drug use",
        "keywords": [
            "Anti-bacterial agents",
            "Intraoperative period"
        ],
        "year": 2013
    },
    "AwtOtFPv": {
        "id": "AwtOtFPv",
        "title": "Antibiotic Use in The Pediatric Patients of Our Hospital",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "Clinical Pharmacy Center,The First People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "PU Zhen",
                "org": "Dept.of Pharmacy,Medical College of Tibet University,Lhasa ,China"
            },
            {
                "name": "LIU Jin-yong",
                "org": "Clinical Pharmacy Center,The First People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "SUN Zeng-xian",
                "org": "Clinical Pharmacy Center,The First People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            }
        ],
        "venue": "evaluation and analysis of drug-use in hospitals of china",
        "keywords": [
            "Antibacterials",
            "Pediatrics",
            "Rational drug use",
            "DDDs"
        ],
        "year": 2012
    },
    "6UyWyzxu": {
        "id": "6UyWyzxu",
        "title": "Literature Analysis of 124 Cases of Fosfomycin-induced ADR",
        "authors": [
            {
                "name": "LIU Jin-yong",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Jiangsu Lianyungang ,China"
            },
            {
                "name": "SUN Zeng-xian",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Jiangsu Lianyungang ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Jiangsu Lianyungang ,China"
            },
            {
                "name": "ZHOU Jin-yu",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Jiangsu Lianyungang ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Jiangsu Lianyungang ,China"
            }
        ],
        "venue": "china pharmacy",
        "keywords": [
            "Fosfomycin",
            "Literature analysis",
            "Adverse drug reactions"
        ],
        "year": 2012
    },
    "WGOv2juh": {
        "id": "WGOv2juh",
        "title": "Therapeutic Effect of Antibacterials against Acinetobacter Baumannii Infection in Our Hospital",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "Clinical Pharmacy Center,Lianyun-gang Municipal First Peoples\u2019 Hospital of Jiangsu Province,Lianyungang ,China"
            },
            {
                "name": "SUN Zeng-xian",
                "org": "Clinical Pharmacy Center,Lianyun-gang Municipal First Peoples\u2019 Hospital of Jiangsu Province,Lianyungang ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "Clinical Pharmacy Center,Lianyun-gang Municipal First Peoples\u2019 Hospital of Jiangsu Province,Lianyungang ,China"
            },
            {
                "name": "ZHOU Jin-yu",
                "org": "Clinical Pharmacy Center,Lianyun-gang Municipal First Peoples\u2019 Hospital of Jiangsu Province,Lianyungang ,China"
            },
            {
                "name": "CUI Yan",
                "org": "Clinical Pharmacy Center,Lianyun-gang Municipal First Peoples\u2019 Hospital of Jiangsu Province,Lianyungang ,China"
            }
        ],
        "venue": "china pharmacy",
        "keywords": [
            "Antibacterials",
            "Acinetobacter baumannii",
            "Therapeutic effect"
        ],
        "year": 2010
    },
    "yHbjFIDC": {
        "id": "yHbjFIDC",
        "title": "Drug Resistance of Acinetobacter Baumanii and Medication Strategy",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Lianyungang ,China"
            },
            {
                "name": "SUN Zeng-xian",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Lianyungang ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Lianyungang ,China"
            },
            {
                "name": "ZHOU Jin-yu",
                "org": "Clinical Pharmacy Center,Lianyungang First People's Hospital,Lianyungang ,China"
            }
        ],
        "venue": "evaluation and analysis of drug-use in hospitals of china",
        "keywords": [
            "Acinetobacter Baumanii",
            "Drug resistance",
            "Antimicrobial agents"
        ],
        "year": 2009
    },
    "tTpyEEkP": {
        "id": "tTpyEEkP",
        "title": "Evaluation and adjustment of individualized dosage regimen of cyclosporin",
        "authors": [
            {
                "name": "SUN Zeng-xian",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "ZHAO Li-dong",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "ZHOU Jin-yu",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "HONG Rong",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "LIU Jin-yong",
                "org": "Clinic Pharmacy Research Center,No.1 People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            }
        ],
        "venue": "chinese journal of hospital pharmacy",
        "keywords": [
            "nonlinear kinetics",
            "cyclosporin A",
            "individualized dosage regimen",
            "pharmacokinetic properties",
            "linear kinetics"
        ],
        "year": 2012
    },
    "cAk3oTYr": {
        "id": "cAk3oTYr",
        "title": "Determination of residual organic solvents by GC",
        "authors": [
            {
                "name": "SONG Xing-fa",
                "org": "The First Hospital of Lianyungang,Lianyungang ,Chain"
            },
            {
                "name": "ZHOU Jun",
                "org": "The First Hospital of Lianyungang,Lianyungang ,Chain"
            },
            {
                "name": "GAO Shan",
                "org": "The First Hospital of Lianyungang,Lianyungang ,Chain"
            }
        ],
        "venue": "strait pharmaceutical journal",
        "keywords": [
            "Residual organic solvent",
            "1",
            "Gas chromatography",
            "Ethyl acetate",
            "N-dimethylacetamide",
            "N",
            "4-ethyl acetate",
            "Ethanol"
        ],
        "year": 2009
    },
    "lJk1cx5E": {
        "id": "lJk1cx5E",
        "title": "Survey of clinical utilization of Levofloxacin Injection in our hospital",
        "authors": [
            {
                "name": "OUYANG Chun",
                "org": ".Department of Pharmacy, the First People\u2019s Hospital of Lianyungang City, Lianyungang ,China"
            },
            {
                "name": "GAO Shan",
                "org": ".Department of Pharmacy, the First People\u2019s Hospital of Lianyungang City, Lianyungang ,China"
            },
            {
                "name": "TANG jie",
                "org": ".Department of Pharmacy, the First People\u2019s Hospital of Lianyungang City, Lianyungang ,China"
            }
        ],
        "venue": "chinese journal of modern drug application",
        "keywords": [
            "Analysis of utilization",
            "Levofloxacin",
            "Rational administration"
        ],
        "year": 2012
    },
    "OS8zRstZ": {
        "id": "OS8zRstZ",
        "title": "Risk factors for Acinetobacter baumanniiinfections",
        "authors": [
            {
                "name": "GAO Shan",
                "org": "First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "SUN Zeng-xian",
                "org": "First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "MAO Hai-feng",
                "org": "First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "ZHOU Jin-yu",
                "org": "First People\u2032s Hospital of Lianyungang,Lianyungang,Jiangsu ,China"
            }
        ],
        "venue": "chinese journal of nosocomiology",
        "keywords": [
            "Survey",
            "Acinetobacter baumannii",
            "Risk factors"
        ],
        "year": 2012
    },
    "Atu3uCi6": {
        "id": "Atu3uCi6",
        "title": "Survey of the precautionary application of antibiotics in 390 clean surgical operations during perioperative period",
        "authors": [
            {
                "name": "OUYANG Chun",
                "org": "Lianyungang No.1 People\u2032s Hospital,Lianyungang,Jiangsu,"
            },
            {
                "name": "GAO Shan",
                "org": "Lianyungang No.1 People\u2032s Hospital,Lianyungang,Jiangsu,"
            }
        ],
        "venue": "journal of clinical medicine in practice",
        "keywords": [
            "rational drug use",
            "perioperative period",
            "type \u2160 incision operations",
            "antimicrobial agents"
        ],
        "year": 2012
    },
    "ogJ8ArDG": {
        "id": "ogJ8ArDG",
        "title": "Utilization of Glucocorticoids in Pediatric Inpatients in The First People's Hospital of Lianyungang",
        "authors": [
            {
                "name": "FAN Yan",
                "org": "Dept.of Pharmacy,The First People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "LIU Jin-yong",
                "org": "Dept.of Pharmacy,The First People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            },
            {
                "name": "GAO Shan",
                "org": "Dept.of Pharmacy,The First People's Hospital of Lianyungang,Jiangsu Lianyungang ,China"
            }
        ],
        "venue": "evaluation and analysis of drug-use in hospitals of china",
        "keywords": [
            "Pediatric",
            "Rational drug utilization",
            "Glucocorticoids"
        ],
        "year": 2012
    },
    "xBDDESyc": {
        "id": "xBDDESyc",
        "title": "Comparative analysis of antimicrobial usage in inpatients before and after intervention",
        "authors": [
            {
                "name": "LI Ru-biao",
                "org": ",et al.The First People's Hospital of Lianyungang city,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "GAO Shan",
                "org": ",et al.The First People's Hospital of Lianyungang city,Lianyungang,Jiangsu ,China"
            },
            {
                "name": "BAO Hua",
                "org": ",et al.The First People's Hospital of Lianyungang city,Lianyungang,Jiangsu ,China"
            }
        ],
        "venue": "chinese journal of clinical rational drug use",
        "keywords": [
            "Drug utilization analysis",
            "Inpatients",
            "Intervention measures",
            "Antibacterial"
        ],
        "year": 2011
    },
    "2tC8fPck": {
        "id": "2tC8fPck",
        "title": "Evaluation and Choice of Cyclosporine A Monitoring Strategy",
        "authors": [
            {
                "name": "SUN Zeng-xian",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "XING Xiao-dong",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "ZHAO Li-dong",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "ZHOU Jin-yu",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "GAO Shan",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "ZHANG Qian-feng",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "LIU Jin-yong",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            },
            {
                "name": "HONG Rong",
                "org": "School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing ,China"
            }
        ],
        "venue": "china pharmacy",
        "keywords": [
            "Evaluation",
            "Cyclosporine A",
            "Monitoring strategy",
            "Limited sampling strategy",
            "Validation",
            "Abbreviated AUC_(0\uff5e12h)"
        ],
        "year": 2011
    },
    "KueVVFr8": {
        "id": "KueVVFr8",
        "title": "Effect of PPARG on AGEs-induced AKT/MTOR signaling-associated human chondrocytes autophagy.",
        "abstract": "Accumulation of advanced glycation end products (AGEs) in articular cartilage is thought to represent a major risk factor for osteoarthritis development. In this study we aimed to probe the role of AGEs in human chondrocytes and to determine the impact of the peroxisome proliferator-activated receptor-\u03b3 (PPARG) on AGEs-induced cell autophagy. Cell viability was measured after human chondrocytes were treated with different concentrations of AGEs with or without the PPARG inhibitor, T0070907, or agonist, pioglitazone. Autophagy activation markers (MAP2LC3, BECN1 and SQSTM1/P62), expression of PPARG and the phosphorylation levels of Akt/MTOR were determined by Western blotting; autophagosome formation was analyzed by transmission electron microscopy (TEM); autophagic flux was detected with mRFP-GFP-LC3 tandem construct. Low doses of AGEs over a short amount of time stimulated chondrocyte proliferation and autophagy by limiting phosphorylation of Akt/MTOR signaling. The addition of PPARG inhibitor T0070907 lead to defective autophagy. High dose and long exposure to AGEs inhibited cell viability and autophagy by increasing phosphorylation levels of Akt/MTOR signaling. The agonist, pioglitazone, was shown to protect cell autophagy in a dose-dependent manner. Our findings suggest AGEs can downregulate PPARG and that PPARG maintains cell viability by activating the Akt/MTOR signaling pathway as well as inducing chondrocyte autophagy.",
        "keywords": [
            "Advanced Glycation End-products",
            "MTOR",
            "PPARG",
            "autophagy",
            "chondrocytes"
        ],
        "authors": [
            {
                "name": "Zhao-Jun Wang",
                "org": "Department of Orthopedics, The Second Affiliated Hospital of Hunan Normal University, The 163rd Central Hospital of the People's Liberation Army, Changsha, 410003, Hunan, People's Republic of China."
            },
            {
                "name": "Hai-Bin Zhang",
                "org": "Department of Orthopedics, The Second Affiliated Hospital of Hunan Normal University, The 163rd Central Hospital of the People's Liberation Army, Changsha, 410003, Hunan, People's Republic of China."
            },
            {
                "name": "Cheng Chen",
                "org": "Department of Orthopedics, The Second Affiliated Hospital of Hunan Normal University, The 163rd Central Hospital of the People's Liberation Army, Changsha, 410003, Hunan, People's Republic of China."
            },
            {
                "name": "Hao Huang",
                "org": "Department of Orthopedics, The Second Affiliated Hospital of Hunan Normal University, The 163rd Central Hospital of the People's Liberation Army, Changsha, 410003, Hunan, People's Republic of China."
            },
            {
                "name": "Jian-Xia Liang",
                "org": "Department of Orthopedics, The Second Affiliated Hospital of Hunan Normal University, The 163rd Central Hospital of the People's Liberation Army, Changsha, 410003, Hunan, People's Republic of China."
            }
        ],
        "venue": "Cell biology international",
        "year": 2018
    },
    "FbqRceu1": {
        "id": "FbqRceu1",
        "title": "The Function of PPAR\u03b3/AMPK/SIRT-1 Pathway in Inflammatory Response of Human Articular Chondrocytes Stimulated by Advanced Glycation End Products.",
        "abstract": "Accumulation of advanced glycation end products (AGEs) in the articular cartilage is a major risk factor for osteoarthritis (OA). To determine the mechanistic basis of AGE action in OA, we treated human articular chondrocytes with AGEs, and found that they not only up-regulated the pro-inflammatory cytokines interleukin (IL)-1\u03b2 and tumor necrosis factor (TNF)-\u03b1, but also inhibited AMP-activated protein kinase (AMPK) phosphorylation and decreased sirtuin 1 (SIRT-1) levels in a concentration- and time-dependent manner. Pioglitazone, a peroxisome proliferator-activated receptor-\u03b3 (PPAR\u03b3) agonist restored the inhibited AMPK and SIRT-1 by AGEs. Pre-treatment of the cells with the agonists or antagonists of AMPK and SIRT-1 respectively abolished and augmented the inflammatory state induced by AGEs. Furthermore, AMPK agonist also restored the levels of SIRT-1 in the AGE-stimulated chondrocytes. Our findings indicate AGEs induce an inflammatory response in human articular chondrocytes via the PPAR\u03b3/AMPK/SIRT-1 pathway, which is therefore a potential target in OA therapy.",
        "keywords": [
            "AMP-activated protein kinase",
            "advanced glycation end product",
            "chondrocyte",
            "inflammatory"
        ],
        "authors": [
            {
                "name": "Hao Huang",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Zhao-Jun Wang",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Hai-Bin Zhang",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Jian-Xia Liang",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Wen-Dong Cao",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Qi Wu",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Chao-Peng He",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            },
            {
                "name": "Cheng Chen",
                "org": "Department of Orthopedics, The 921st Hospital of the People's Liberation Army, The Second Affiliated Hospital of Hunan Normal University."
            }
        ],
        "venue": "Biological & pharmaceutical bulletin",
        "year": 2019
    },
    "ZSYDF7xm": {
        "id": "ZSYDF7xm",
        "title": "Effect of PPARG on AGEs-induced AKT/MTOR signaling-associated human chondrocytes autophagy: Autophagy in AGEs-induced chondrocytes",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhao-Jun Wang",
                "org": ""
            },
            {
                "name": "Hai-Bin Zhang",
                "org": ""
            },
            {
                "name": "Cheng Chen",
                "org": ""
            },
            {
                "name": "Hao Huang",
                "org": ""
            },
            {
                "name": "Jian-Xia Liang",
                "org": ""
            }
        ],
        "venue": "Cell Biology International",
        "year": 2018
    },
    "xOOCKai5": {
        "authors": [
            {
                "name": "Xue Wang",
                "org": "College of Civil Engineering"
            },
            {
                "name": "Yuanchen Guo",
                "org": "College of Civil Engineering"
            }
        ],
        "title": "A Summary of strength formation mechanism of light wall material",
        "abstract": "The lisht wall material is one of the major trends of wall materials currently Light weight wall material is made of active mineral powder as a main raw material and P. O cement as a cementious material. Spent foam plastic and some admixtures were added, foamed and cured in the nature under the ordinary temperature and pressure condition. The article introduces and analyzes exhaustively the strength mechanism of lisht wall material and prepares theoretical basis for the preparation of high-strength lisht wall material. \u00a9 (2012) Trans Tech Publications, Switzerland.",
        "keywords": [
            "Light wall material",
            "Strength mechanism",
            "Summary"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2012,
        "id": "xOOCKai5"
    },
    "7ChdBMaJ": {
        "authors": [
            {
                "name": "Yuan-Chen Guo",
                "org": "Department of Architectural Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "Department of Architectural Engineering"
            },
            {
                "name": "Ke-Wei Sun",
                "org": "National Engineering Research Center of Waste Resource Recovery"
            },
            {
                "name": "Long-Fei Cheng",
                "org": "Department of Architectural Engineering"
            }
        ],
        "title": "Experiment study on drying shrinkage deformation of recycled aggregate concrete",
        "abstract": "Drying shrinkage deformation is one of the most important reasons which causes cracking of concrete materials. Mix design of C30 natural aggregate concrete(NAC) is used as reference, the experiment of drying shrinkage considering the influence of recycled aggregate replacement ratio and mixing amount of fly ash, water reducer, and expansive agent was made. The results show that: In the case of fixed amount of mixing water and cement content, the addition of water reducing agent and recycled aggregate increase the shrinkage deformation of recycled aggregate concrete(RAC); to a certain extent, the addition of fly ash can inhibit the shrinkage deformation of RAC; with the addition of expansive agent, the shrinkage deformation of RAC significantly reduce, and this inhibitory effect is stronger than fly ash's. \u00a9 2011 IEEE.",
        "keywords": [
            "drying shrinkage deformation",
            "experiment study",
            "recycled aggregate",
            "recycled aggregate concrete"
        ],
        "venue": "2011 International Conference on Electric Technology and Civil Engineering, ICETCE 2011 - Proceedings",
        "year": 2011,
        "id": "7ChdBMaJ"
    },
    "FHA37o6R": {
        "authors": [
            {
                "name": "Yuanchen Guo",
                "org": "College of Civil Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "College of Civil Engineering"
            }
        ],
        "title": "Experimental study on forecasting mathematical model of drying shrinkage of recycled aggregate concrete",
        "abstract": "On the basis of basic law in AASHTO2007 model, the forecasting mathematical model of drying shrinkage of recycled aggregate concrete (RAC) is established by regression analysis and experimental study. The research results show that (1) with the replacement rate of RCA increases, the drying shrinkage value of RAC increases; this trend is even more obvious in the early drying time. (2) The addition of fly ash can inhibit the drying shrinkage of RAC, but the effect is not very obvious. Specifically, the addition of fly ash will increase the shrinkage to some extent when the mixing amount is 20%. (3) The addition of expansive agent can obviously inhibit the shrinkage of RAC; the inhibition affection is better than that of fly ash. (4) The forecasting mathematical models of drying shrinkage of RAC established in this paper have high accuracy and rationality according to experiment validation and error analysis. Copyright \u00a9 2012 Yuanchen Guo and Xue Wang.",
        "keywords": [
            ""
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2012,
        "id": "FHA37o6R"
    },
    "Ff2Esqew": {
        "authors": [
            {
                "name": "Yuanchen Guo",
                "org": "College of Civil Engineering"
            },
            {
                "name": "Jueshi Qian",
                "org": "College of Materials Science and Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "College of Civil Engineering"
            }
        ],
        "title": "Pore structure and influence of recycled aggregate concrete on drying shrinkage",
        "abstract": "Pore structure plays an important role in the drying shrinkage of recycled aggregate concrete (RAC). High-precision mercury intrusion and water evaporation were utilized to study the pore structure of RAC, which has a different replacement rate of recycled concrete aggregate (RCA), and to analyze its influence on drying shrinkage. Finally, a fractal-dimension calculation model was established based on the principles of mercury intrusion and fractal-geometry theory. Calculations were performed to study the pore-structure fractal dimension of RAC. Results show the following. (1) With the increase in RCA content, the drying shrinkage values increase gradually. (2) Pores with the greatest impact on concrete shrinkage are those whose sizes ranging from 2.5 nm to 50 nm and from 50 nm to 100 nm. In the above two ranges, the proportions of RAC are greater than those of RC0 (natural aggregate concrete, NAC), which is the main reason the shrinkage values of RAC are greater than those of NAC. (3) The pore structure of RAC has good fractal feature, and the addition of RCA increases the complexity of the pore surface of concrete. \u00a9 2013 Yuanchen Guo et al.",
        "keywords": [
            ""
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2013,
        "id": "Ff2Esqew"
    },
    "DdrVI6xL": {
        "authors": [
            {
                "name": "Yuanchen Guo",
                "org": ""
            },
            {
                "name": "Xue Wang",
                "org": ""
            },
            {
                "name": "Jueshi Qian",
                "org": ""
            }
        ],
        "title": "Experimental research on the wettability of recycled aggregate concrete with fly ash",
        "abstract": "Material adsorption, the reverse process of evaporation diffusion, directly reflects the wettability of materials. Wettability is one of the main factors that affect the drying shrinkage of materials. A device that measures the wettability of recycled aggregate concrete (RAC) with fly ash is proposed in this study based on pore structure theory. The isothermal absorption curve of RAC is examined with different fly ash contents. Results show that as the recycled aggregate replacement rate increases, the moisture absorption capacity of RAC gradually increases. The addition of fly ash improves the porosity of RAC structures and reduces material wettability. \u00a9 Gou et al.; Licensee Bentham Open.",
        "keywords": [
            "Drying shrinkage",
            "Experimental research",
            "Fly ash",
            "Recycled aggregate concrete",
            "Wettability"
        ],
        "venue": "Open Civil Engineering Journal",
        "year": 2013,
        "id": "DdrVI6xL"
    },
    "oMufiDrt": {
        "authors": [
            {
                "name": "Xue Wang",
                "org": ""
            },
            {
                "name": "Yuanchen Guo",
                "org": ""
            }
        ],
        "title": "Experimental research on strengthen mechanism of NaOH on light wall materials prepared from crushed brick powder",
        "abstract": "Crushed brick light weight wall material, which was made of crushed brick as a main raw material and P\u2022S cement as a cementious material. Crushed foam glass and some admixtures were added, is prepared under the ordinary temperature and pressure condition. The main research in this paper is if NaOH has good alkaline excitation on crushed brick light weight wall material through experimental research and mechanism analysis. Studies have shown that: (1) The main chemical composition of crushed brick powder are SiO \n                        ",
        "keywords": [
            "Crushed brick powder",
            "Light wall material",
            "NaOH",
            "Strengthen mechanism"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "oMufiDrt"
    },
    "CALRgHuQ": {
        "authors": [
            {
                "name": "Xue Wang",
                "org": ""
            },
            {
                "name": "Yuanchen Guo",
                "org": ""
            }
        ],
        "title": "Experimental research on foamed concrete block with high addition crushed brick powder",
        "abstract": "Crushed brick foamed concrete block is made of crushed brick as a main raw material and Portland cement as a cementious material, mixed with various additives, foamed by foamer and cured under the ordinary temperature and pressure condition. Studies have shown that: (1) The main chemical composition of CBP are SiO",
        "keywords": [
            "Crushed brick powder",
            "Experimental research",
            "Foamed concrete block"
        ],
        "venue": "Advanced Materials Research",
        "year": 2013,
        "id": "CALRgHuQ"
    },
    "pq8tExkt": {
        "authors": [
            {
                "name": "Yuan-Chen Guo",
                "org": "Department of Architectural Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "Department of Architectural Engineering"
            },
            {
                "name": "Ke-Wei Sun",
                "org": "National Engineering Research Center of Waste Resource Recovery"
            }
        ],
        "title": "Finite element analysis on moisture distribution within RAC under standard drying conditions",
        "abstract": "With the mass diffusion module of ABAQUS, the moisture diffusion behavior of recycled aggregate concrete material (RAC) was investigated in this work. The simulation was carried out under the standard drying conditions (Ambient humidity: H=60%; Temperature: T=20\u00b0C). The results indicate that: with the dry age grows, the water evaporation begins from the RAC's surface first, and the water concentration reaches the equilibrium value rapidly; then the evaporation process gradually extends to the interior, but the process is quit slowly. In moisture diffusion process, the water concentration takes on gradient distribution. the calculated value of water concentration matches well with the experiment results, and can provide a theoretical base to the caculation of drying shrinkage stress of RAC. \u00a9 (2011) Trans Tech Publications, Switzerland.",
        "keywords": [
            "Finite element analysis",
            "Mass diffusion",
            "Moisture migration",
            "Recycled aggregate",
            "Recycled aggregate concrete",
            "Water concentration field"
        ],
        "venue": "Advanced Materials Research",
        "year": 2011,
        "id": "pq8tExkt"
    },
    "44i9Po8V": {
        "authors": [
            {
                "name": "Yuanchen Guo",
                "org": "College of Civil Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "College of Civil Engineering"
            }
        ],
        "title": "Experimental research on isothermal sorption of RAC material",
        "abstract": "Material adsorption process is the reverse process of evaporation diffusion, reflecting directly the wetting degree of material, is one of the main factors of material drying shrinkage. Based on pore structure theory, this article designed a device measuring the wetting properties of materials, tested different recycled aggregate replacement rate recycled aggregate concrete isothermal absorption curve. The article proposes the water contact angle can be calculated from the initial absorption curve, and analyzes its impact on drying shrinkage of recycled aggregate concrete. \u00a9 (2011) Trans Tech Publications, Switzerland.",
        "keywords": [
            "Drying shrinkage",
            "Hygroscopic capacity",
            "Recycled aggregate concrete",
            "Wettability"
        ],
        "venue": "Advanced Materials Research",
        "year": 2011,
        "id": "44i9Po8V"
    },
    "uqiLcN0Y": {
        "authors": [
            {
                "name": "Yuan-Chen Guo",
                "org": "College of Civil Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "College of Civil Engineering"
            },
            {
                "name": "Yun-Xiang He",
                "org": "College of Civil Engineering"
            }
        ],
        "title": "Isothermal sorption of recycled aggregate concrete and its influence on drying shrinkage",
        "abstract": "Based on pore structure theory, a device for measuring the wetting properties of materials was designed. The effect of recycled aggregate replacement rate, and water reducer, expansive agent, fly ash dosage on isothermal absorption of recycled aggregate concrete was investigated. Through curve fitting, the function relationship of isothermal absorption curve of recycled aggregate concrete with different mix proportion was established. It is proposed that the water contact angle can be calculated from the initial absorption curve, and its impact on drying shrinkage of recycled aggregate concrete is analyzed. Research results show that the addition of recycled aggregate and superplasticizer lowers the contact angle of recycled aggregate concrete, and increases the drying shrinkage. The addition of fly ash improves the pore structure of concrete, and can reduce the wettability, which can help inhibit the shrinkage of recycled aggregate concrete; It is difficult to explain the shrinkage mechanism of expanded recycled concrete only from material wettability and pore structure theory.",
        "keywords": [
            "Drying shrinkage",
            "Hygroscopic capacity",
            "Recycled aggregate concrete (RAC)",
            "Wettability"
        ],
        "venue": "Jianzhu Cailiao Xuebao/Journal of Building Materials",
        "year": 2012,
        "id": "uqiLcN0Y"
    },
    "mULuwNQg": {
        "authors": [
            {
                "name": "Yuanchen Guo",
                "org": "College of Materials Science and Engineering, Chongqing University"
            },
            {
                "name": "Jueshi Qian",
                "org": "College of Materials Science and Engineering, Chongqing University"
            },
            {
                "name": "Xue Wang",
                "org": "College of Civil Engineering, Chongqing Three Gorges University"
            },
            {
                "name": "Zhengyi Yan",
                "org": "College of Civil Engineering, Chongqing Three Gorges University"
            },
            {
                "name": "Huadong Zhong",
                "org": "College of Civil Engineering, Chongqing Three Gorges University"
            }
        ],
        "title": "Influence of Aggregate Wettability with Different Lithology Aggregates on Concrete Drying Shrinkage",
        "abstract": "The correlation of the wettability of different lithology aggregates and the drying shrinkage of concrete materials is studied, and some influential factors such as wettability and wetting angle are analyzed. A mercury porosimeter is used to measure the porosities of different lithology aggregates accurately, and the pore size ranges that significantly affect the drying shrinkage of different lithology aggregate concretes are confirmed. The pore distribution curve of the different coarse aggregates is also measured through a statistical method, and the contact angle of different coarse aggregates and concrete is calculated according to the linear fitting relationship. Research shows that concrete strength is determined by aggregate strength. Aggregate wettability is not directly correlated with concrete strength, but wettability significantly affects concrete drying shrinkage. In all types' pores, the greatest impacts on wettability are capillary pores and gel pores, especially for the pores of the size locating 2.5-50 nm and 50-100 nm two ranges.",
        "keywords": [
            ""
        ],
        "venue": "Advances in Materials Science and Engineering",
        "year": 2015,
        "id": "mULuwNQg"
    },
    "zbEpDg37": {
        "authors": [
            {
                "name": "Jun Shi",
                "org": "Key Laboratory of Yangtze River Water Environment, Ministry of Education"
            },
            {
                "name": "Min Zhang",
                "org": "Division of Cardiology"
            },
            {
                "name": "Libin Zhang",
                "org": "First People's Hospital of Yunnan Province"
            },
            {
                "name": "Pin Wang",
                "org": "First People's Hospital of Yunnan Province"
            },
            {
                "name": "Li Jiang",
                "org": "Division of Cardiology"
            },
            {
                "name": "Huiping Deng",
                "org": "Key Laboratory of Yangtze River Water Environment, Ministry of Education"
            }
        ],
        "title": "Xylose-fermenting Pichia stipitis by genome shuffling for improved ethanol production",
        "abstract": "Xylose fermentation is necessary for the bioconversion of lignocellulose to ethanol as fuel, but wild-type Saccharomyces cerevisiae strains cannot fully metabolize xylose. Several efforts have been made to obtain microbial strains with enhanced xylose fermentation. However, xylose fermentation remains a serious challenge because of the complexity of lignocellulosic biomass hydrolysates. Genome shuffling has been widely used for the rapid improvement of industrially important microbial strains. After two rounds of genome shuffling, a genetically stable, high-ethanol-producing strain was obtained. Designated as TJ2-3, this strain could ferment xylose and produce 1.5 times more ethanol than wild-type Pichiastipitis after fermentation for 96h. The acridine orange and propidium iodide uptake assays showed that the maintenance of yeast cell membrane integrity is important for ethanol fermentation. This study highlights the importance of genome shuffling in P.stipitis as an effective method for enhancing the productivity of industrial strains. Designated as TJ2-3, this strain could ferment xylose and produce 1.5 times more ethanol than wild-type P. stipitis after fermentation for 96 h. The acridine orange and propidium iodide uptake assays showed that the maintenance of yeast cell membrane integrity is important for ethanol fermentation. This study highlights the importance of genome shuffling in P. stipitis as an effective method for enhancing the productivity of industrial strains. \u00a9 2013 The Authors.",
        "keywords": [
            ""
        ],
        "venue": "Microbial Biotechnology",
        "year": 2014,
        "id": "zbEpDg37"
    },
    "3EV26kev": {
        "id": "3EV26kev",
        "title": "miR-194 Inhibits Liver Cancer Stem Cell Expansion by Regulating RAC1 pathway.",
        "abstract": "Liver cancer stem cells (CSCs) contribute to tumorigenesis, progression, drug resistance and recurrence of hepatocellular carcinoma (HCC). However, the underlying mechanism for the propagation of liver CSCs remains unclear. Herein, we observed low expression of miR-194 in chemoresistant HCC cells. A remarkable decrease of miR-194 was detected in EpCAM or CD133-positive liver CSCs and CSC-enriched hepatoma spheres. Interference miR-194 facilitated liver CSCs expansion by enhancing the self-renewal of liver CSCs. While up-regulating miR-194 inhibited liver CSCs expansion by suppressing the self-renewal of liver CSCs. Furthermore, hepatoma cells with miR-194 overexpression performed more sensitivity to sorafenib treatment. Mechanistically, functional studies found that Ras-related C3 botulinum toxin substrate 1 (RAC1) was a direct target of miR-194. Overexpression of miR-194 inhibited the expression of RAC1 in liver CSCs. Special RAC1 siRNA diminished the discrepancy in liver CSC proportion and the self-renewal capacity between miR-194 overexpression hepatoma cells and control cells, which further confirmed that RAC1 was required in miR-194-inhibited liver CSCs expansion. More importantly, downregulated expression of miR-194 was a predictor of poor prognosis of HCC patients.",
        "keywords": [
            "RAC1,sorafenib",
            "hepatocellular carcinoma",
            "liver cancer stem cell",
            "miR-194"
        ],
        "authors": [
            {
                "name": "Rong-Zheng Ran",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China; Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China."
            },
            {
                "name": "Jun Chen",
                "org": "Department of Pharmacy, Third Affiliated Hospital of Second Military Medical University, 225 Changhai Road, 200438 Shanghai, China."
            },
            {
                "name": "Long-Jiu Cui",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China."
            },
            {
                "name": "Xiao-Lu Lin",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China."
            },
            {
                "name": "Ming-Ming Fan",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China."
            },
            {
                "name": "Zhuang-Zhi Cong",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China."
            },
            {
                "name": "Hai Zhang",
                "org": "Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China."
            },
            {
                "name": "Wei-Feng Tan",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China; Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. Electronic address: tanw1231@sina.com."
            },
            {
                "name": "Qing-Guo Zhang",
                "org": "Department of Pharmacy, Third Affiliated Hospital of Second Military Medical University, 225 Changhai Road, 200438 Shanghai, China. Electronic address: guoqing_zhang91@126.com."
            },
            {
                "name": "Yong-Jie Zhang",
                "org": "Department of laparoscopic surgery, Third Affiliated Hospital of Second Military Medical University, Shanghai, 200438, China. Electronic address: Drzhangyongjie@163.com."
            }
        ],
        "venue": "Experimental cell research",
        "year": 2019
    },
    "UiIcTZxU": {
        "id": "UiIcTZxU",
        "title": "Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats.",
        "abstract": "The aim of this study was to compare the pharmacokinetics of baicalin and wogonoside in rats following oral administration of Xiaochaihu Tang (Minor Radix Bupleuri Decoction) and Radix scutellariae extract. Thus, a specific LC-MS method was developed and validated for the determination of these flavonoids in the plasma of rats after oral administration Xiaochaihu Tang and Radix scutellariae extract. Chromatographic separation was performed on a Zorbax SB C(18) column (150mmx4.6mm, i.d.: 5microm) with 0.1% formic acid in water and acetonitrile by linear gradient elution. Baicalin, wogonoside and carbamazepine (internal standard, I.S.) were detected in select-ion-monitoring (SIM) mode with a positive electrospray ionization (ESI) interface. The following ions: m/z 447 for baicalin, m/z 461 for wogonoside and m/z 237 for the I.S. were used for quantitative determination. The calibration curves were linear over the concentration ranges from 0.1231 to 6.156microg mL(-1) for baicalin and 0.08832 to 4.416microg mL(-1) for wogonoside. The lower limit of detection (LLOD) based on a signal-to-noise ratio of 2 was 0.06155microg mL(-1) for baicalin and 0.04416microg mL(-1) for wogonoside. Intra-day and inter-day precisions (RSD%) were within 10% and accuracy (RE%) ranged from -6.4 to 4.4%. The extraction recovery at three QC concentrations ranged from 74.7 to 86.0% for baicalin and from 71.3 to 83.7% for wogonoside. The plasma concentrations of baicalin and wogonoside in rats at designated time periods after oral administration were successfully determined using the validated method, pharmacokinetic parameters were estimated by a non-compartment model. Following oral administration of Xiaochaihu Tang and Radix scutellariae extract, the t(1/2) of baicalin was 3.60+/-0.90 and 5.64+/-1.67, the C(max1) was 1.64+/-0.99 and 5.66+/-2.02, the t(max1) was 0.13+/-0.05 and 0.20+/-0.07, the C(max2) was 2.43+/-0.46 and 3.18+/-1.66, and the t(max2) were 6.40+/-1.67 and 5.66+/-2.02, respectively. Following oral administration of Xiaochaihu Tang and Radix scutellariae extract, the t(1/2) of wogonoside was 4.97+/-1.68 and 7.71+/-1.55, the C(max1) was 1.39+/-0.83 and 1.45+/-0.37, the t(max1) was 0.21+/-0.20 and 0.17+/-0.01, the C(max2) was 1.90+/-0.55 and 1.42+/-0.70, and the t(max2) was 5.60+/-1.67 and 5.20+/-1.79, respectively. A significant difference (p<0.05) was observed for t(1/2), and the elimination of baicalin and wogonoside in Xiaochaihu Tang was increased.",
        "keywords": [
            "pharmacokinetics",
            "mass spectrometry",
            "wogonoside",
            "liquid chromatography",
            "baicalin",
            "internal standard",
            "compartment model",
            "lower limit of detection",
            "signal to noise ratio",
            "selected ion monitoring",
            "electrospray ionization",
            "liquid chromatography mass spectrometry"
        ],
        "authors": [
            {
                "name": "Zhenyu Zhu",
                "org": "School of Pharmacy, Second Military Medical University, No. 325, Guohe Road, Shanghai 200433, China"
            },
            {
                "name": "Liang Zhao",
                "org": ""
            },
            {
                "name": "Xiaofan Liu",
                "org": "School of Pharmacy, Second Military Medical University, No. 325, Guohe Road, Shanghai 200433, China"
            },
            {
                "name": "Jun Chen",
                "org": "Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China"
            },
            {
                "name": "Hai Zhang",
                "org": "Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China"
            },
            {
                "name": "Guoqing Zhang",
                "org": "Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China"
            },
            {
                "name": "Yifeng Chai",
                "org": ""
            }
        ],
        "venue": "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences",
        "year": 2010
    },
    "sDUShVtM": {
        "id": "sDUShVtM",
        "title": "RRLC-TOF/MS in identification of constituents and metabolites of Radix Saposhnikoviae in rat plasma and urine",
        "abstract": "Objective: To analyze the constituents and metabolites of Radix Sa poshnikoviae (RS) in rat plasma and urine by rapid-resolution liquid chromatography-time of flight mass spectrometry (RRLC-TOF/MS), so as to explore the active ingredients and metabolites of RS in vivo. Methods: The separation was performed on a Angilent Zorbax Extend-C14 (5 \u03bcm, 250 mm x 4.6 mm id) column, with a methanol-water mobile phase system used for gradient elution. Time-of-flight mass spectrometer (TOF/MS) was applied for qualitative analysis under positive ion mode. Based on the accurate molecular weight of TOF/MS detection and the compound list of RS established previously, the constituents and metabolites of RS in different matrix in vivo were identified. Results: Six constituents of RS were identified in the plasma, sucrose, prim-O-glucosylcimifugin, cimifugin, nodakenetin, 5-O-methylvisamminol, and 3\u2032-O-i-butyrylhammaudol. Eight constituents were identified in the urine, prim-O-glucosylcimifugin, divaricatacid, cimifugin, 4\u2032-O-glucosyl-5-O- methylvisamminol, (3S)-2,2-dimethyl-3, 5-dihydroxy-8-hydroxymethyl-3, 4-dihydro-2H, 6H-benzo-[1, 2-b: 5, 4-b\u2032] dipyran-6-one, 5-O-methylvisamminol, see-O-\u03b2-D-glucosylhammaudol, and wogonin. Two metabolites were identified in the urine, glucuronide of cimifujin and an isomer of it. Conclusion: The present method is reliable and effective for identifying compounds of RS in vivo, and it can provide a reference and evidence for the further pharmacodynamics experiments.",
        "keywords": [
            "Metabolites",
            "Plasma",
            "Radix saposhnikoviae",
            "Rapid-resolution liquid chromatography-time of flight mass spectrometry",
            "Urine"
        ],
        "authors": [
            {
                "name": "Yueyue Li",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Hui Wang",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Jun Chen",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Liang Zhao",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Hai Zhang",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Yifeng Chai",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Guoqing Zhang",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2010
    },
    "H3X8odRz": {
        "id": "H3X8odRz",
        "title": "RRLC-TOF/MS in identification of constituents and metabolites of <I>Radix Saposhnikoviae</I> in rat plasma and urine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yue-yue LI",
                "org": ""
            },
            {
                "name": "Hui WANG",
                "org": ""
            },
            {
                "name": "Jun CHEN",
                "org": ""
            },
            {
                "name": "Liang ZHAO",
                "org": ""
            },
            {
                "name": "Hai ZHANG",
                "org": ""
            },
            {
                "name": "Yi-feng CHAI",
                "org": ""
            },
            {
                "name": "Guo-qing ZHANG",
                "org": ""
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2010
    },
    "kgRikamK": {
        "id": "kgRikamK",
        "title": "Capillary electrophoresis for analysis of optical impurity of L-pramipexole",
        "abstract": "Objective: To develop a capillary electrophoresis system for purity test and enantioseparation of L-pramipexole. Methods: Using \u03b2-CD, HP-\u03b2-CD, SBE-\u03b2-CD and DM-\u03b2-CD as chiral selection agents, we investigated the influence of concentration, pH of chiral selection agent and column length and inner diameter on chiral separation. The enantiomers were baseline separated under the following conditions-uncoated fused silica capillary (50 \u03bcm X 47 cm) with an effective length of 40 cm, back-ground electrolyte solution, 40 mmol/l trisodium citrate buffer solution, 0.5% SBE-\u03b2-CD, pH 4.0 adjusted by phosphoric acid, 5% methanol, 25 mmol\u00b7L-1 SDS, 40 mmol\u00b7L-1 sodium tetraborate solution as running buffer, and 16 kV separation voltage. The detection wavelength was set at 254 nm and the column temperature was 30*C. Results: The baseline separation of L-pramipexole was obtained under our condition. The optical isomerism had satisfactory resolution (Rs>2.5) and the content of R-pramipexole was less than 0.5%. Conclusion: The proposed method is simple, reliable and can be used for routine purity test and chiral separation.",
        "keywords": [
            "Capillary electrophoresis",
            "Enantioseparation",
            "L-pramipexole",
            "R-pramipexole"
        ],
        "authors": [
            {
                "name": " Liu",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Qingyan Sun",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Chunquan Sheng",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Hai Zhang",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Jun Chen",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Liang Zhao",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            },
            {
                "name": "Yifeng Chai",
                "org": "Second Military Medical University(Second Military Medical University),Shanghai,China"
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2009
    },
    "e94DCWK8": {
        "id": "e94DCWK8",
        "title": "Capillary electrophoresis for analysis of optical impurity of L-pramipexole",
        "abstract": "Objective:To develop a capillary electrophoresis system for purity test and enantioseparation of L-pramipexole.Methods:Using \u03b2-CD,HP-\u03b2-CD,SBE-\u03b2-CD and DM-\u03b2-CD as chiral selection agents,we investigated the influence of concentration,pH of chiral selection agent and column length and inner diameter on chiral separation.The enantiomers were baseline separated under the following conditions-uncoated fused silica capillary(50 \u03bcm \u00d7 47 cm) with an effective length of 40 cm,back-ground electrolyte solution:40 mmol/l trisodium citrate buffer solution,0.5% SBE-\u03b2-CD,pH 4.0 adjusted by phosphoric acid,5% methanol,25 mmol\u00b7L-1 SDS,40 mmol\u00b7L-1 sodium tetraborate solution as running buffer,and 16 kV separation voltage.The detection wavelength was set at 254 nm and the column temperature was 30\u2103.Results:The baseline separation of L-pramipexole was obtained under our condition.The optical isomerism had satisfactory resolution(Rs>2.5) and the content of R-pramipexole was less than 0.5%.Conclusion:The proposed method is simple,reliable and can be used for routine purity test and chiral separation.",
        "keywords": [
            "L-pramipexole",
            "capillary electrophoresis",
            "enantioseparation",
            "R-pramipexole"
        ],
        "authors": [
            {
                "name": "Chang-hai LIU",
                "org": ""
            },
            {
                "name": "Qing-yan SUN",
                "org": ""
            },
            {
                "name": "Chun-quan SHENG",
                "org": ""
            },
            {
                "name": "Hai ZHANG",
                "org": ""
            },
            {
                "name": "Jun CHEN",
                "org": ""
            },
            {
                "name": "Liang ZHAO",
                "org": ""
            },
            {
                "name": "Yi-feng CHAI",
                "org": ""
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2009
    },
    "8EVwmnTm": {
        "id": "8EVwmnTm",
        "title": "Relighting abstracted image via salient edge-guided luminance field optimization: Relighting abstracted image",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "enhua wu",
                "org": ""
            },
            {
                "name": "xun wang",
                "org": ""
            },
            {
                "name": "hong li",
                "org": ""
            },
            {
                "name": "chunxiao liu",
                "org": ""
            },
            {
                "name": "qunsheng peng",
                "org": ""
            }
        ],
        "venue": "Computer Animation and Virtual Worlds",
        "year": 2013
    },
    "OG2IKRR5": {
        "id": "OG2IKRR5",
        "title": "Salient region detection via locally smoothed label propagation",
        "abstract": "Background prior and label propagation have been widely advocated for salient region detection. However, traditional background prior based models heuristically assume that all or parts of the pixels on the image boundary are background. And the label propagation based models only consider the pairwise smoothness in optimization. To tackle these two shortcomings, we propose a framework which utilizes background prior and label propagation to generate more reliable saliency maps. Firstly, a novel optimal seeds estimation strategy is proposed to adaptively and robustly choose the most informative seeds from refined background map and foreground prior. Then, a new label propagation model which takes into account both the pairwise and local smoothness constraint is proposed to learn the saliency score according to the estimated background and foreground seeds. Last but not least, we present a new application of salient region detection named attention driven image abstraction. Both quantitative and qualitative evaluations on three widely used datasets demonstrate the superiority of the proposed method to other several state-of-the-art methods.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Li",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macau 999078, China"
            },
            {
                "name": "Enhua Wu",
                "org": "State Key Laboratory of Computer Science, Institute of Software, Chinese Academy of Sciences, Beijing 100864, China"
            },
            {
                "name": "Wen Wu",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macau 999078, China"
            }
        ],
        "venue": "Neurocomputing",
        "year": 2017
    },
    "b4lkGjJw": {
        "id": "b4lkGjJw",
        "title": "Robust Salient Object Detection and Segmentation.",
        "abstract": "Background prior has been widely used in many salient object detection models with promising results. These methods assume that the image boundary is all background. Then, color feature based methods are used to extract the salient object. However, such assumption may be inaccurate when the salient object is partially cropped by the image boundary. Besides, using only color feature is also insufficient. We present a novel salient object detection model based on background selection and multi-features. Firstly, we present a simple but effective method to pick out more reliable background seeds. Secondly, we utilize multi-features enhanced graph-based manifold ranking to get the saliency maps. Finally, we also present the salient object segmentation via computed saliency map. Qualitative and quantitative evaluation results on three widely used data sets demonstrate significant appeal and advantages of our technique compared with many state-of-the art models.",
        "keywords": [],
        "authors": [
            {
                "name": "Hong Li",
                "org": ""
            },
            {
                "name": "Wen Wu",
                "org": ""
            },
            {
                "name": "Enhua Wu",
                "org": ""
            }
        ],
        "venue": "ICIG",
        "year": 2015
    },
    "9Fie2wxy": {
        "id": "9Fie2wxy",
        "title": "Salient region detection via locally smoothed label propagation: With application to attention driven image abstraction.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Li",
                "org": ""
            },
            {
                "name": "Enhua Wu",
                "org": ""
            },
            {
                "name": "Wen Wu",
                "org": ""
            }
        ],
        "venue": "Neurocomputing",
        "year": 2017
    },
    "PFicOkqS": {
        "id": "PFicOkqS",
        "title": "Toward adaptive fusion of multiple cues for salient region detection.",
        "abstract": "Boundary priors have been extensively studied in salient region detection problems over the past few decades. Although several models based on the boundary prior have achieved good detection performance, there still exist drawbacks. The most common one is that they fail to detect the salient object when the background is complex or the salient object touches the image boundary. In this paper, we propose a novel model to detect the salient region. It is based on background cues and one complementary cue, that is, a foreground cue. A saliency score is obtained via solving an energy optimization problem which takes both the background cue and foreground cue into consideration. Extensive experiments, including both quantitative and qualitative evaluations on five widely used datasets, demonstrate the superiority of our proposed model to several other state-of-the-art models.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Li",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macao 999078, China"
            },
            {
                "name": "Enhua Wu",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macao 999078, China"
            },
            {
                "name": "Wen Wu",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macao 999078, China"
            }
        ],
        "venue": "Journal of the Optical Society of America. A, Optics, image science, and vision",
        "year": 2016
    },
    "K1wlvLoD": {
        "id": "K1wlvLoD",
        "title": "Robust interactive image segmentation via graph-based manifold ranking.",
        "abstract": "Interactive image segmentation aims at classifying the image pixels into foreground and background classes given some foreground and background markers. In this paper, we propose a novel framework for interactive image segmentation that builds upon graph-based manifold ranking model, a graph-based semi-supervised learning technique which can learn very smooth functions with respect to the intrinsic structure revealed by the input data. The final segmentation results are improved by overcoming two core problems of graph construction in traditional models: graph structure and graph edge weights. The user provided scribbles are treated as the must-link and must-not-link constraints. Then we model the graph as an approximatively k-regular sparse graph by integrating these constraints and our extended neighboring spatial relationships into graph structure modeling. The content and labels driven locally adaptive kernel parameter is proposed to tackle the insufficiency of previous models which usually employ a unified kernel parameter. After the graph construction, a novel three-stage strategy is proposed to get the final segmentation results. Due to the sparsity and extended neighboring relationships of our constructed graph and usage of superpixels, our model can provide nearly real-time, user scribble insensitive segmentations which are two core demands in interactive image segmentation. Last but not least, our framework is very easy to be extended to multi-label segmentation, and for some less complicated scenarios, it can even get the segmented object through single line interaction. Experimental results and comparisons with other state-of-the-art methods demonstrate that our framework can efficiently and accurately extract foreground objects from background.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Li",
                "org": ""
            },
            {
                "name": "Wen Wu",
                "org": ""
            },
            {
                "name": "Enhua Wu",
                "org": ""
            }
        ],
        "venue": "Computational Visual Media",
        "year": 2015
    },
    "wyTOAvJs": {
        "id": "wyTOAvJs",
        "title": "Salient region detection via unit boundary distribution and energy optimization.",
        "abstract": "Due to recent rapid development of computer vision applications such as object recognition and image segmentation, it has become increasingly important to generate reliable saliency maps to uniformly highlight the desired salient object. In this paper, we present a novel bottom-up salient region detection method by exploiting contrast prior and the relationship between the salient region detection and graph based semi-supervised learning problem. First, we compute a preliminary initial saliency map by a newly proposed technique named unit boundary distribution and several refinement schemes. Second, after obtaining the indication map generated via a double threshold operation on the initial saliency map, we model the final saliency inference problem as a graph based semi-supervised learning approach by solving a energy minimization problem. Both quantitative and qualitative evaluations on three widely used datasets demonstrate the superiority of the proposed method to other twenty-one state-of-the-art methods.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Li",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macau, China 999078"
            },
            {
                "name": "Enhua Wu",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macau, China 999078 and State Key Laboratory of Computer Science, Institute of Software, Chi ..."
            },
            {
                "name": "Wen Wu",
                "org": "Department of Computer and Information Science, Faculty of Science and Technology, University of Macau, Macau, China 999078"
            }
        ],
        "venue": "Multimedia Tools Appl.",
        "year": 2017
    },
    "LUXmrjQm": {
        "authors": [
            {
                "name": "Lujuan Gao",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            },
            {
                "name": "Yue Hu",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            },
            {
                "name": "Chunya Ni",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            },
            {
                "name": "Yu Xu",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            },
            {
                "name": "Li Ma",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            },
            {
                "name": "Shuxian Yan",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            },
            {
                "name": "Xia Dou",
                "org": "Department of Dermatology, Huashan Hospital Fudan University"
            }
        ],
        "title": "Retrospective study of photopatch testing in a Chinese population during a 7-year period",
        "abstract": "Background: Photoallergic contact dermatitis (PACD) is of importance in a proportion of photodermatoses and can be evaluated through photopatch testing (PPT). Objectives: The objectives of this study were to evaluate the results of PPT and investigate the prevalence of PACD reactions to different photoallergens in Chinese patients at the Department of Dermatology of Huashan Hospital Fudan University during a 7-year period. Methods: A retrospective PPT study was conducted. During the 7 years, 4957 patients attending for investigation of suspected photodermatoses were tested according to the European consensus methodology with up to 14 allergens prepared according to Chinese National Standards. The reactions were scored using the International Contact Dermatitis Research Group visual scoring system. Results: A total of 3472 PACD reactions in 2454 subjects (49.5%) were recorded. The most common agents were chlorpromazine (44.3%), followed by para-aminobenzoic acid (14.7%), thimerosal (8.9%), and sulfanilamide (6.9%). Allergic contact dermatitis reactions comprised 409 reactions in 399 subjects (8%). Photoinhibition and photoaugmentation of allergic contact dermatitis compromised 3810 reactions in 2412 subjects and 11 reactions in 11 subjects, respectively. Irritant reactions (1928 reactions) were seen in 1140 subjects. Conclusions: The most predominant photoallergens in our region were chlorpromazine, para-aminobenzoic acid, thimerosal, and sulfanilamide, which likely reflected the particular exposures of this Chinese population. \u00a9 2014 American Contact Dermatitis Society. All Rights Reserved.",
        "keywords": [
            ""
        ],
        "venue": "Dermatitis",
        "year": 2014,
        "id": "LUXmrjQm"
    },
    "9ksneN3w": {
        "authors": [
            {
                "name": "Qi-Qun Cheng",
                "org": "Key Laboratory of Marine and Estuarine Fisheries"
            },
            {
                "name": "Da-Ru Lu",
                "org": "State Key Laboratory of Genetic Engineering"
            },
            {
                "name": "Li Ma",
                "org": "State Key Laboratory of Genetic Engineering"
            }
        ],
        "title": "Morphological differences between close populations discernible by multivariate analysis: A case study of genus Coilia (Teleostei: Clupeiforms)",
        "abstract": "In order to understand the morphological differences between four populations of genus Coilia (Teleostei: Clupeiforms) and identify them conveniently, truss network data were used to conduct multivariate analysis. Nineteen morphometric measurements were made for each individual. Burnaby's multivariate method was used to obtain size-adjusted shape data. The cluster analysis and discriminant analysis were used to discriminate among populations. The results indicated that 1) the four populations were clustered into three distinct groups; the first group included Changjiang C. mystus and Taihu C. ectenes, the second one included Zhujiang C. mystus, the last one included Changjiang C. ectenes, and 2) discriminant analysis with selected 4 morphological parameters showed that the identification accuracy was between 88% and 100%, and global identification accuracy was 95%. Our result showed that populations of different Coilia species living in geographic proximity to one another are more similar than conspecifics living farther apart. Separation and adaption are important to morphological difference. The taxonomy of genus Coilia should be reconsidered. This study also showed that the method to obtain size-adjusted data is important to acquire right conclusion. \u00a9 EDP Sciences, IFREMER, IRD 2005.",
        "keywords": [
            "Cluster analysis",
            "Coilia ectenes",
            "Coilia mystus",
            "Discriminant analysis stock identification"
        ],
        "venue": "Aquatic Living Resources",
        "year": 2005,
        "id": "9ksneN3w"
    },
    "gZojL7TL": {
        "id": "gZojL7TL",
        "title": "Enhancement of 1,3-Dihydroxyacetone Production from Gluconobacter oxydans by Combined Mutagenesis.",
        "abstract": "Wild strain L-6 was subjected to combined mutagenesis, including UV irradiation, atmospheric and room temperature plasma, and ion beam implantation, to increase the yield of 1,3-dihydroxyacetone (DHA). With application of a high-throughput screening method, mutant  I-2-239 with a DHA productivity of 103.5 g/l in flask-shake fermentation was finally obtained with the starting glycerol concentration of 120 g/l, which was 115.7% higher than the wild strain. The cultivation time also decreased from 54 h to 36 h. Compared with the wild strain, a dramatic increase in enzyme activity was observed for the mutant strain, although the increase in biomass was limited. DNA and amino acid sequence alignment revealed 11 nucleotide substitutions and 10 amino acid substitutions between the  of strains L-6 and I-2-239. Simulation of the 3-D structure and prediction of active site residues and PQQ binding site residues suggested that these mutations were mainly related to PQQ binding, which was speculated to be favorable for the catalyzing capacity of glycerol dehydrogenase. RT-qPCR assay indicated that the transcription levels of  and  in the mutant strain were respectively 4.8-fold and 5.4-fold higher than that in the wild strain, suggesting another possible reason for the increased DHA productivity of the mutant strain.",
        "keywords": [
            "1",
            "3-Dihydroxyacetone",
            "bioconversion",
            "combined mutagenesis",
            "enzyme activity",
            "fermentation",
            "glycerol"
        ],
        "authors": [
            {
                "name": "Xi Lin",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Sha Liu",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Guangrong Xie",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Jing Chen",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Penghua Li",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Jianhua Chen",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            }
        ],
        "venue": "Journal of microbiology and biotechnology",
        "year": 2016
    },
    "caPzHF1G": {
        "id": "caPzHF1G",
        "title": "Production of N \u03b1 -acetyl T\u03b11-HSA through in vitro acetylation by RimJ.",
        "abstract": "Thymosin alpha 1 (T\u03b11) is an important immunomodulating agent with various clinical applications. The natural form of T\u03b11 is  -acetylated, which was supposed to be related to  stability of the hormone. In this study, fusion protein T\u03b11-HSA was constructed and expressed in . RimJ, a  -acetyltransferase from , was also overexpressed and purified to homogeneity.  acetylation of T\u03b11-HSA in the presence of RimJ and acetyl coenzyme A resulted in  -acetyl T\u03b11-HSA. The  -acetylation was determined by LC-MS/MS. Kinetic assay indicated that RimJ had a higher affinity to desacetyl T\u03b11 than to T\u03b11-HSA. Bioactivity assay revealed fully retained activity of T\u03b11 when the hormone was connected to the N-terminus of the fusion protein, while the activity was compromised in our previously constructed HSA-T\u03b11. With fully retained activity and N-terminal acetylation,  -acetyl T\u03b11-HSA was expected to be a more promising pharmaceutical agent than T\u03b11.",
        "keywords": [
            "RimJ",
            "acetylation",
            "bioactivity",
            "human serum albumin",
            "thymosin alpha 1"
        ],
        "authors": [
            {
                "name": "Jing Chen",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Haibin Li",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Tao Wang",
                "org": "Department of Neurosurgery, Shanghai 5th People's Hospital, Shanghai Medical College, Fudan University, Shanghai 200240, China."
            },
            {
                "name": "Shuyang Sun",
                "org": "Overseas Education College, Nanjing Tech University, Nanjing 211816, China."
            },
            {
                "name": "Jia Liu",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            },
            {
                "name": "Jianhua Chen",
                "org": "School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China."
            }
        ],
        "venue": "Oncotarget",
        "year": 2017
    },
    "Q3eOoZDb": {
        "id": "Q3eOoZDb",
        "title": "Enhancement of 1,3-Dihydroxyacetone Production from Gluconobacter oxydans by Combined Mutagenesis.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xi Lin",
                "org": ""
            },
            {
                "name": "Sha Liu",
                "org": ""
            },
            {
                "name": "Guangrong Xie",
                "org": ""
            },
            {
                "name": "Jing Chen",
                "org": ""
            },
            {
                "name": "Penghua Li",
                "org": ""
            },
            {
                "name": "Jianhua Chen",
                "org": ""
            }
        ],
        "venue": "Journal of Microbiology and Biotechnology",
        "year": 2016
    },
    "pPVKkfb4": {
        "id": "pPVKkfb4",
        "title": "Production of N \u03b1 -acetyl T\u03b11-HSA through in vitro acetylation by RimJ",
        "abstract": "//      Jing Chen 1,  * , Haibin Li 1,  * , Tao Wang 2,  * , Shuyang Sun 3 , Jia Liu 1  and Jianhua Chen 1     1 School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China    2 Department of Neurosurgery, Shanghai 5th People\u2019s Hospital, Shanghai Medical College, Fudan University, Shanghai 200240, China    3 Overseas Education College, Nanjing Tech University, Nanjing 211816, China    * These authors have contributed equally to this work   Correspondence to:   Jianhua Chen, email:  chenjhnj@163.com     Keywords:  thymosin alpha 1, human serum albumin, RimJ, acetylation, bioactivity    Received:  May 30, 2017\u00a0\u00a0\u00a0\u00a0\u00a0 Accepted:  July 13, 2017\u00a0\u00a0\u00a0\u00a0\u00a0 Published:  August 14, 2017     ABSTRACT   Thymosin alpha 1 (T\u03b11) is an important immunomodulating agent with various clinical applications. The natural form of T\u03b11 is  N \u03b1  -acetylated, which was supposed to be related to  in vivo  stability of the hormone. In this study, fusion protein T\u03b11-HSA was constructed and expressed in  Pichia pastoris . RimJ, a  N \u03b1  -acetyltransferase from  E.coli , was also overexpressed and purified to homogeneity.  In vitro  acetylation of T\u03b11-HSA in the presence of RimJ and acetyl coenzyme A resulted in  N \u03b1  -acetyl T\u03b11-HSA. The  N \u03b1  -acetylation was determined by LC-MS/MS. Kinetic assay indicated that RimJ had a higher affinity to desacetyl T\u03b11 than to T\u03b11-HSA. Bioactivity assay revealed fully retained activity of T\u03b11 when the hormone was connected to the N-terminus of the fusion protein, while the activity was compromised in our previously constructed HSA-T\u03b11. With fully retained activity and N-terminal acetylation,  N \u03b1  -acetyl T\u03b11-HSA was expected to be a more promising pharmaceutical agent than T\u03b11.",
        "keywords": "",
        "authors": [
            {
                "name": "Jing Chen",
                "org": ""
            },
            {
                "name": "Haibin Li",
                "org": ""
            },
            {
                "name": "Tao Wang",
                "org": ""
            },
            {
                "name": "Shuyang Sun",
                "org": ""
            },
            {
                "name": "Jia Liu",
                "org": ""
            },
            {
                "name": "Jianhua Chen",
                "org": ""
            }
        ],
        "venue": "Oncotarget",
        "year": 2017
    },
    "EvyArRtL": {
        "authors": [
            {
                "name": "Y. Tao",
                "org": ""
            },
            {
                "name": "B. Zhou",
                "org": ""
            },
            {
                "name": "G. Xia",
                "org": ""
            },
            {
                "name": "F. Wang",
                "org": ""
            },
            {
                "name": "Z. Wu",
                "org": ""
            },
            {
                "name": "M. Fu",
                "org": ""
            }
        ],
        "title": "Exposure to L-Ascorbic Acid or \u03b1-Tocopherol Facilitates the Development of Porcine Denuded Oocytes from Metaphase I to Metaphase II and Prevents Cumulus Cells from Fragmentation",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Reproduction in Domestic Animals",
        "year": 2004,
        "id": "EvyArRtL"
    },
    "KYd4ew8c": {
        "authors": [
            {
                "name": "N. Yu",
                "org": "Department of Dermatology, Shanghai Skin Disease Hospital"
            },
            {
                "name": "S. Liu",
                "org": "Department of Clinical Laboratory, Taizhou Municipal Hospital"
            },
            {
                "name": "X. Yi",
                "org": "Department of Dermatology, Shanghai Skin Disease Hospital"
            },
            {
                "name": "S. Zhang",
                "org": "Experimental Research Center, Eye and ENT Hospital"
            },
            {
                "name": "Y. Ding",
                "org": "Department of Dermatology, Shanghai Skin Disease Hospital"
            }
        ],
        "title": "Serum amyloid A induces interleukin-1\u03b2 secretion from keratinocytes via the NACHT, LRR and PYD domains-containing protein 3 inflammasome",
        "abstract": "Interleukin (IL)-1\u03b2 is now emerging as a critical cytokine in the pathogenesis of T helper type 17 (Th17)-mediated skin diseases, including psoriasis. Psoriatic keratinocytes are a major source of IL-1\u03b2; however, the mechanisms triggering IL-1\u03b2 processing remain unknown. Recently, an acute-phase protein serum amyloid A (SAA) has been identified as a danger signal that triggers inflammasome activation and IL-1\u03b2 secretion. In this study, we detected increased SAA mRNA and protein expression in psoriatic epidermis. In cultured keratinocytes, SAA up-regulated the expression of pro-IL-1\u03b2 and secretion of mature IL-1\u03b2. On the transcriptional level, blocking Toll-like receptor-2 (TLR-2), TLR-4 or nuclear factor kappa B (NF-\u03baB) attenuated SAA-induced expression of IL-1\u03b2 mRNA. SAA up-regulated caspase-1 and NACHT, LRR and PYD domains-containing protein 3 (NLRP3) expression in keratinocytes. Inhibiting caspase-1 activity and silencing NLRP3 decreased IL-1\u03b2 secretion, confirming NLRP3 as the SAA-responsive inflammasome on the post-transcriptional level. The mechanism of SAA-triggered NLRP3 activation and subsequent IL-1\u03b2 secretion was found to involve the generation of reactive oxygen species. Finally, the expression of SAA by keratinocytes was up-regulated by IL-17A. Taken together, our results indicate that keratinocyte-derived SAA triggers a key inflammatory mediator, IL-1\u03b2, via NLRP3 inflammasome activation, providing new potential targets for the treatment of this chronic skin disease.",
        "keywords": [
            "IL-1\u03b2",
            "Inflammasome",
            "Keratinocytes",
            "Psoriasis",
            "Serum amyloid A"
        ],
        "venue": "Clinical and Experimental Immunology",
        "year": 2015,
        "id": "KYd4ew8c"
    },
    "vD0ATbZM": {
        "authors": [
            {
                "name": "Yi Ding",
                "org": "Hefei National Laboratory for Physical Sciences at Microscale"
            },
            {
                "name": "Shu-Hong Yu",
                "org": "Hefei National Laboratory for Physical Sciences at Microscale"
            },
            {
                "name": "Chen Liu",
                "org": "Hefei National Laboratory for Physical Sciences at Microscale"
            },
            {
                "name": "Zheng-An Zang",
                "org": "Hefei National Laboratory for Physical Sciences at Microscale"
            }
        ],
        "title": "3D architectures of iron molybdate: Phase selective synthesis, growth mechanism, and magnetic properties",
        "abstract": "Monoclinic and orthorhombic Fe",
        "keywords": [
            "Hydrothermal synthesis",
            "Iron",
            "Magnetic properties",
            "Molybdenum",
            "Phase control"
        ],
        "venue": "Chemistry - A European Journal",
        "year": 2007,
        "id": "vD0ATbZM"
    },
    "EycQN8PJ": {
        "authors": [
            {
                "name": "Xu Li",
                "org": "Department of Oncology"
            },
            {
                "name": "Zhixin Bie",
                "org": "Department of Oncology"
            },
            {
                "name": "Zijin Zhang",
                "org": "Department of Oncology"
            },
            {
                "name": "Yuanming Li",
                "org": "Department of Oncology"
            },
            {
                "name": "Xueqing Hu",
                "org": "Department of Oncology"
            },
            {
                "name": "Wenbo Liu",
                "org": "Department of Oncology"
            },
            {
                "name": "Shuai Zhang",
                "org": "Department of Oncology"
            },
            {
                "name": "Gang Cheng",
                "org": "Department of Oncology"
            },
            {
                "name": "Bin Ai",
                "org": "Department of Oncology"
            }
        ],
        "title": "Clinical analysis of 64 patients with lung-cancer-associated hypercalcemia",
        "abstract": "Objective: This study investigated the factors influencing survival time of patients with lung-cancer-associated hypercalcemia. Data and Methods: A total of 64 pathologically confirmed patients with Stage IV lung-cancer-associated hypercalcemia were enrolled from Beijing Hospitals between August 2010 and July 2015. Clinical materials included patients' gender, age, pathological type, highest albumin-corrected calcium level, serum alkaline phosphatase level, creatinine clearance rate, organ (bone, liver, brain, and adrenal gland) metastasis, number of distal metastatic sites, and survival time after diagnosis of hypercalcemia. Univariate and multivariate analyses were performed to screen the risk factors affecting patients' survival. Results: Albumin-corrected calcium levels of the 64 patients ranged from 2.56 to 4.57 mmol/L, and the median value was 2.76 mmol/L. Survival time after diagnosis of hypercalcemia varied from 1 to 1340 days, and the median survival time was 104 days. Univariate analysis showed that gender, age (>60-year-old), albumin-corrected calcium levels, elevation of alkaline phosphatases, brain metastasis, and number of distal metastatic sites were predictors for poor survival (P = 0.026, P = 0.022, P < 0.001, P = 0.043, P = 0.041, P = 0.003). In Cox proportional hazard model analysis, corrected hypercalcemia levels and alkaline phosphatase levels were determined to be risk factors affecting patients' survival time (hazard ratio [HR] = 6.828, P = 0.000; HR = 1.957, P = 0.026). Conclusions: Patients with Stage IV lung-cancer-associated moderate and severe hypercalcemia exhibited shorter survival time and poor prognosis. After correction, moderate and severe elevations of hypercalcemia and abnormal elevation of alkaline phosphatase levels were shown to be significant factors shortening patients' survival time.",
        "keywords": [
            "Hypercalcemia",
            "Lung cancer",
            "Survival time"
        ],
        "venue": "Journal of Cancer Research and Therapeutics",
        "year": 2015,
        "id": "EycQN8PJ"
    },
    "h06DhIxA": {
        "authors": [
            {
                "name": "Jian Zhang",
                "org": "Zhoushan Electric Power Supply Company, State Grid"
            },
            {
                "name": "Xin Long Zheng",
                "org": "Zhoushan Electric Power Supply Company, State Grid"
            },
            {
                "name": "Guo Zhi Chen",
                "org": "Zhoushan Electric Power Supply Company, State Grid"
            },
            {
                "name": "Zhi Gang Zhang",
                "org": "Zhoushan Electric Power Supply Company, State Grid"
            },
            {
                "name": "Bei Bei Xu",
                "org": "Zhoushan Electric Power Supply Company, State Grid"
            }
        ],
        "title": "Economic comparison of VSC-HVDC and HVAC systems for connections of offshore wind farms",
        "abstract": "Large-scale offshore wind power has been developed in recent years, and two possibilities are considered for the transmission system between the offshore wind farms and the onshore grid: VSC-HVDC and HVAC. The paper aims to compare both systems for 300MW offshore wind farms, 25 km, 50km and 75km from the Point of Common Coupling on an economic basis using a DCF(discounted cash flow) analysis. A linear fit to the net present values has been made, obtaining the break-even distance of 47km. When the transmission distance is shorter than 47km, the HVAC system is more economic, otherwise the VSC-HVDC system is a more cost-efficient option.",
        "keywords": [
            "DCF",
            "Economic analysis",
            "HVAC",
            "Offshore wind power",
            "VSC-HVDC"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2014,
        "id": "h06DhIxA"
    },
    "Hgic89Sh": {
        "id": "Hgic89Sh",
        "title": "Effects of physical training in chronic heart failure",
        "abstract": "Eleven patients with chronic heart failure secondary to ischaemic heart disease (mean [SEM] age 63\u00b70 [2\u00b73] years; left ventricular ejection fraction 19 [8]%) undertook 8 weeks of home-based bicycle exercise training and 8 weeks of activity restriction (rest) in a physician-blind, random-order, crossover trial. Training increased exercise duration from 14\u00b72 (1\u00b71) min to 16\u00b78 (1\u00b73) min and peak oxygen consumption from 14\u00b73 (1\u00b71) ml.min -1 .kg -1 to 16\u00b77 (1\u00b73) ml.min -1 .kg -1 . Heart rates at submaximum workloads and rate-pressure products were significantly reduced by training, and there was also a significant improvement in patient-rated symptom scores. No adverse events occurred during the training phase. Thus home-based physical training programmes are feasible even in severe chronic heart failure and have a beneficial effect on exercise tolerance, peak oxygen consumption, and symptoms. The commonly held belief that rest is the mainstay of treatment of chronic heart failure should no longer be accepted.",
        "keywords": [
            "physical training"
        ],
        "authors": [
            {
                "name": "A.J.S. Coats",
                "org": ""
            },
            {
                "name": "S. Adamopoulos",
                "org": "Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK"
            },
            {
                "name": "T.E. Meyer",
                "org": "Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK"
            },
            {
                "name": "J. Conway",
                "org": "Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK"
            },
            {
                "name": "P. Sleight",
                "org": "Department of Cardiovascular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK"
            }
        ],
        "venue": "The Lancet",
        "year": 1990
    },
    "MRQJBlYi": {
        "id": "MRQJBlYi",
        "title": "Cardiovascular research in the pharmaceutical industry: a personal appeal for rationalizing development.",
        "abstract": "",
        "keywords": [
            "cardiovascular research",
            "pharmaceutical industry",
            "drug development",
            "innovative research",
            "Cardiovascular research",
            "Drug development"
        ],
        "authors": [
            {
                "name": "J. Conway",
                "org": "Department of Cardiovascular Medicine|John Radcliffe Hospital"
            }
        ],
        "venue": "European journal of clinical pharmacology",
        "year": 1993
    },
    "u3k0a5Hi": {
        "id": "u3k0a5Hi",
        "title": "Validation of the beat to beat measurement of blood velocity in the human ascending aorta by a new high temporal resolution Doppler ultrasound spectral analyser",
        "abstract": "",
        "keywords": [
            "cardiology",
            "spectrum analysis",
            "temporal resolution",
            "cardiac output"
        ],
        "authors": [
            {
                "name": "A J S Coats",
                "org": ""
            },
            {
                "name": "C Murphy",
                "org": ""
            },
            {
                "name": "J Conway",
                "org": ""
            },
            {
                "name": "P Sleight",
                "org": ""
            }
        ],
        "venue": "Heart",
        "year": 1992
    },
    "Dt6tiVFt": {
        "id": "Dt6tiVFt",
        "title": "Effects of endurance training on baroreflex sensitivity and blood pressure in borderline hypertension",
        "abstract": "Physical training offers a potential non-pharmacological strategy for control of mild and borderline hypertension, but its effect on blood pressure is controversial. We investigated the effects of endurance training on waking and sleeping blood pressure and on baroreflex sensitivity in 16 borderline hypertensive patients. First, 8 patients were assessed before and after a 6-month endurance training programme. Then, when it was clear that blood pressures were lower after training, a further 8 patients were studied not only at the end of the training programme but also after 4 months' abstention from exercise (detraining). Measurements were taken of baroreflex sensitivity (response to iv phenylephrine), blood pressure, R-R interval, and blood pressure and R-R variability. Ambulatory blood pressures were measured in 13 patients (7 trained, 6 detrained) and sleep blood pressures in 6 patients (3 trained, 3 detrained). Increased fitness was associated with a decline in resting arterial blood pressure of 9\u00b77 (SE 2\u00b70) mm Hg systolic and 6\u00b78 (1\u00b72) mm Hg diastolic, and with a decline in ambulatory blood pressure of 4\u00b78 (1\u00b74) mm Hg and 7\u00b75 (2\u00b71) mm Hg, respectively; both p<0\u00b705. Baroreflex sensitivity was 14\u00b70 (1\u00b78) ms/mm Hg in the unfit and 17\u00b75 (2\u00b70) ms/mm Hg in the fit; p < 0\u00b705. Sleep blood pressures were not lower in the fit despite longer sleep R-R intervals. These findings indicate that, in some subjects with borderline or mild hypertension, a physical training programme is sufficient to bring the blood pressure within normal limits.",
        "keywords": [
            "blood pressure",
            "endurance training"
        ],
        "authors": [
            {
                "name": "V.K. Somers",
                "org": ""
            },
            {
                "name": "J. Conway",
                "org": "Cardiac Department, John Radcliffe Hospital, Headington, Oxford OX2 6UD, UK"
            },
            {
                "name": "J. Johnston",
                "org": "Cardiac Department, John Radcliffe Hospital, Headington, Oxford OX2 6UD, UK"
            },
            {
                "name": "P. Sleight",
                "org": "Cardiac Department, John Radcliffe Hospital, Headington, Oxford OX2 6UD, UK"
            }
        ],
        "venue": "The Lancet",
        "year": 1991
    },
    "EofknEdI": {
        "id": "EofknEdI",
        "title": "Antihypertensive effect of carvedilol: a preliminary dose-response study.",
        "abstract": "The blood pressure (BP) lowering effect of low doses of antihypertensive agents is not usually explored because of the difficulty in detecting small changes in BP. Since ambulatory blood pressure monitoring in a cross-over trial design can reliably detect differences of 5 mmHg with less than 20 subjects, we have used this technique to assess the dose-response curve of a new beta-blocker, carvedilol. Twenty subjects were enrolled after diagnostic ambulatory BP monitoring had shown a day-time average diastolic BP of over 90 mmHg. Three doses of carvedilol (6.25, 12.5 and 25 mg daily) and placebo were then given double-blind in random order for periods of 4 weeks each. No period effects were detected. The antihypertensive effect was statistically significant at doses of 12.5 mg and 25 mg daily. There was, however, no evidence that 25 mg/day produced the peak effect. The lowest dose (6.25 mg/day) produced a small fall in both systolic and diastolic BP but neither of these were significant. We conclude that doses of 12.5 and 25 mg carvedilol once a day are adequate for the treatment of hypertension.",
        "keywords": [
            "reproducibility",
            "double blind cross-over design",
            "//-blockers",
            "ambulatory blood pres- sure monitoring",
            "statistical significance",
            "dose response",
            "ambulatory blood pressure monitoring",
            "blood pressure"
        ],
        "authors": [
            {
                "name": "B. Casadei",
                "org": "Department of Cardiovascular Medicine John Radcliffe Hospital Oxford UK"
            },
            {
                "name": "J. Conway",
                "org": "Department of Cardiovascular Medicine John Radcliffe Hospital Oxford UK"
            },
            {
                "name": "A. J. S. Coats",
                "org": "Department of Cardiovascular Medicine John Radcliffe Hospital Oxford UK"
            },
            {
                "name": "R. Bird",
                "org": "Department of Cardiovascular Medicine John Radcliffe Hospital Oxford UK"
            }
        ],
        "venue": "The Clinical investigator",
        "year": 1992
    },
    "97Weji73": {
        "id": "97Weji73",
        "title": "hypertension Changes in autonomic regulation induced by physical training in mild",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "A Malliani",
                "org": ""
            },
            {
                "name": "M Pagani",
                "org": ""
            },
            {
                "name": "V Somers",
                "org": ""
            },
            {
                "name": "R Furlan",
                "org": ""
            },
            {
                "name": "S Dell' Orto",
                "org": ""
            },
            {
                "name": "J Conway",
                "org": ""
            },
            {
                "name": "G Baselli",
                "org": ""
            },
            {
                "name": "S Cerutti",
                "org": ""
            },
            {
                "name": "P Sleight",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "Hg2TQ4UC": {
        "id": "Hg2TQ4UC",
        "title": "Effect of Maximal Voluntary Exercise on Blood Pressure",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "V.K. Somers",
                "org": ""
            },
            {
                "name": "J. Conway",
                "org": ""
            },
            {
                "name": "M. Lewinter",
                "org": ""
            },
            {
                "name": "P. Sleight",
                "org": ""
            }
        ],
        "venue": "Clinical Science",
        "year": 1985
    },
    "XlWVqRAo": {
        "id": "XlWVqRAo",
        "title": "Ventilation in chronic heart failure: effects of physical training.",
        "abstract": "To assess the effects of exercise training on ventilatory function in chronic heart failure.Observer blinded random allocation crossover training and detraining trial.Assessment in hospital based clinical laboratory; training home based.22 patients with chronic heart failure (New York Heart Association (NYHA) class II or III) recruited from a tertiary referral centre. All finished the study.Bicycle ergometer exercise for 20 minutes a day, five days a week for eight weeks at 70%-80% of maximum heart rate.Exercise capacity on graded incremental exercise test, minute ventilation, oxygen consumption and carbon dioxide output.Peak work load increased from 96 W to 112 W and peak oxygen consumption from 14.1 ml/kg/min to 15.4 ml/kg/min (p < 0.01). At submaximal workloads carbon dioxide excretion (VCO2) and minute ventilation (Vi) decreased significantly (p < 0.05) though oxygen consumption was unchanged. The relation between Vi and carbon dioxide excretion changed: the slope of the Vi to VCO2 plot decreased from 38.6 to 35.3, indicating an improvement in overall ventilary efficiency. The instantaneous carbon dioxide ventilatory equivalent (Vi/VCO2) decreased at submaximal workloads, and reached a lower minimum value after training, indicating that optimum ventilatory performance improved. The exercise capacity of patients was related to the optimum ventilatory performance. It is suggested that this may in part be mediated through changes in skeletal muscles.Exercise training reduces the ventilatory abnormalities in chronic heart failure; thus some of these changes may be due to physical deconditioning.",
        "keywords": [
            "respiration",
            "carbon dioxide",
            "physical training"
        ],
        "authors": [
            {
                "name": "P Davey",
                "org": ""
            },
            {
                "name": "T Meyer",
                "org": ""
            },
            {
                "name": "A Coats",
                "org": ""
            },
            {
                "name": "S Adamopoulos",
                "org": ""
            },
            {
                "name": "B Casadei",
                "org": ""
            },
            {
                "name": "J Conway",
                "org": ""
            },
            {
                "name": "P Sleight",
                "org": ""
            }
        ],
        "venue": "British heart journal",
        "year": 1992
    },
    "30X3HuAR": {
        "id": "30X3HuAR",
        "title": "Cardiac and blood pressure responses to mental stress in reactive hypertensives.",
        "abstract": "To study the haemodynamic response to a standardized mental stress, we measured ascending aorta velocity using Doppler ultrasonography in 20 reactive (\"white-coat\") hypertensives and 20 age and sex matched normal controls (NC) familiar with the hospital setting. Reactive hypertensives (RH) had 3 office diastolic BP recordings between 90-110 mmHg and ambulatory BP less than 140/90 mmHg. The cardiac response to mental arithmetic was greater in RH than NC (minute distance, RH: +36.7 +/- 40.2% vs NC: +10.3 +/- 19%, p less than 0.05; peak velocity, RH: +8.4 +/- 16.5% vs NC: -1.4 +/- 11.9%, p less than 0.05), and there was a different peripheral resistance response (RH: -12.2 +/- 24.2% vs NC: +6.5 +/- 22%, p less than 0.05). We suggest that subjects with reactive hypertension have a strong cardiac response to mental stress and this could be a characteristic of this condition.",
        "keywords": [
            "haemodynamics",
            "blood pressure"
        ],
        "authors": [
            {
                "name": "G. Pannarale",
                "org": ""
            },
            {
                "name": "J. E. Isea",
                "org": ""
            },
            {
                "name": "A. J. S. Coats",
                "org": ""
            },
            {
                "name": "J. Conway",
                "org": ""
            },
            {
                "name": "P. Sleight",
                "org": ""
            }
        ],
        "venue": "Clinical and experimental hypertension. Part A, Theory and practice",
        "year": 1991
    },
    "res8OOew": {
        "id": "res8OOew",
        "title": "Blood pressure changes after upright exercise in normals: evaluation of the role of the autonomic nervous system: ",
        "abstract": "",
        "keywords": [
            "blood pressure"
        ],
        "authors": [
            {
                "name": "M Piepoli",
                "org": ""
            },
            {
                "name": "A J S Coats",
                "org": ""
            },
            {
                "name": "S Adamopoulos",
                "org": ""
            },
            {
                "name": "J Conway",
                "org": ""
            }
        ],
        "venue": "Journal of Hypertension",
        "year": 1991
    },
    "rwbhIWO6": {
        "id": "rwbhIWO6",
        "title": "Ventilation in Chronic Heart Failure",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "P Davey",
                "org": ""
            },
            {
                "name": "T Meyer",
                "org": ""
            },
            {
                "name": "A Coats",
                "org": ""
            },
            {
                "name": "S Adamopoulos",
                "org": ""
            },
            {
                "name": "B Casadei",
                "org": ""
            },
            {
                "name": "J Conway",
                "org": ""
            },
            {
                "name": "P Sleight",
                "org": ""
            }
        ],
        "venue": "Journal of Cardiopulmonary Rehabilitation",
        "year": 1993
    },
    "sc3Djjlg": {
        "id": "sc3Djjlg",
        "title": "Angiotensin-converting enzyme inhibition and physical training in heart failure",
        "abstract": "",
        "keywords": [
            "physical training"
        ],
        "authors": [
            {
                "name": "T. E. MEYER",
                "org": ""
            },
            {
                "name": "B. CASADEI",
                "org": ""
            },
            {
                "name": "A. J. S. COATS",
                "org": ""
            },
            {
                "name": "P. P. DAVEY",
                "org": ""
            },
            {
                "name": "S. ADAMOPOULOS",
                "org": ""
            },
            {
                "name": "A. RADAELLI",
                "org": ""
            },
            {
                "name": "J. CONWAY",
                "org": ""
            }
        ],
        "venue": "Journal of Internal Medicine",
        "year": 1991
    },
    "AyYOYubm": {
        "id": "AyYOYubm",
        "title": "Effect of vagal stimulation by scopoderm TTS on exercise performance and R-R interval variability (RRV) in patients with chronic heart failure (CHF)",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "B. Casadei",
                "org": ""
            },
            {
                "name": "J. Conway",
                "org": ""
            },
            {
                "name": "P. Sleight",
                "org": ""
            }
        ],
        "venue": "Journal of the Autonomic Nervous System",
        "year": 1993
    },
    "5jnolbtd": {
        "id": "5jnolbtd",
        "title": "The Effect of Physical Fitness on Resting Intra-Arterial Blood Pressure",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "V.K. Somers",
                "org": ""
            },
            {
                "name": "J. Conway",
                "org": ""
            },
            {
                "name": "P. Sleight",
                "org": ""
            }
        ],
        "venue": "Clinical Science",
        "year": 1986
    },
    "BPTErXYM": {
        "id": "BPTErXYM",
        "title": "Atrial Natriuretic Peptide is Released by Dynamic Exercise in Man",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "V. Somers",
                "org": ""
            },
            {
                "name": "J. Anderson",
                "org": ""
            },
            {
                "name": "J. Conway",
                "org": ""
            },
            {
                "name": "P. Sleight",
                "org": ""
            },
            {
                "name": "S. Bloom",
                "org": ""
            }
        ],
        "venue": "Hormone and Metabolic Research",
        "year": 1986
    },
    "AsJ9mxOI": {
        "id": "AsJ9mxOI",
        "title": "Mechanisms concerned with blood pressure variability throughout the day.",
        "abstract": "Blood pressure variability throughout the day has been found to be inversely related to baroreflex sensitivity, as is the response to injected phenylephrine, mental stress and sleep. It is concluded that variability in blood pressure results in some degree from defective buffering of blood pressure by the baroreceptors.",
        "keywords": [
            "baroreceptor reflex"
        ],
        "authors": [
            {
                "name": "J. Conway",
                "org": ""
            },
            {
                "name": "N. Boon",
                "org": ""
            },
            {
                "name": "J. Vann Jones",
                "org": ""
            },
            {
                "name": "P. Sleight",
                "org": ""
            }
        ],
        "venue": "Clinical and experimental hypertension. Part A, Theory and practice",
        "year": 1985
    },
    "xHOYVWKL": {
        "authors": [
            {
                "name": "Bo Jiang",
                "org": "Department of Education, University of Soochow"
            },
            {
                "name": "Tingting Tian",
                "org": "Department of Education, University of Soochow"
            }
        ],
        "title": "RETRACTED ARTICLE: Research for urban immigrant children's life satisfaction and adaptation in suzhou",
        "abstract": "Take suzhou migrant children for research object, discusses migrant children's overall situation of life satisfaction and school adaptation and the specific problems for different kinds of migrant children, this research also introducing social support factor which makes important influence to adaptation, explore the social support situation of immigrant children, help them make better adaptation to city life and provides new ideas and suggestions for establishing social support system. \u00a9 2011 IEEE.",
        "keywords": [
            "Life satisfaction",
            "School adaptation",
            "Social support",
            "Urban immigrant children"
        ],
        "venue": "Proceedings - PACCS 2011: 2011 3rd Pacific-Asia Conference on Circuits, Communications and System",
        "year": 2011,
        "id": "xHOYVWKL"
    },
    "gR9bhe2u": {
        "authors": [
            {
                "name": "Lan Wang",
                "org": ""
            },
            {
                "name": "Rikang Wang",
                "org": ""
            },
            {
                "name": "Minghua Jin",
                "org": ""
            },
            {
                "name": "Yingjuan Huang",
                "org": ""
            },
            {
                "name": "Anmin Liu",
                "org": ""
            },
            {
                "name": "Jian Qin",
                "org": ""
            },
            {
                "name": "Meihui Chen",
                "org": ""
            },
            {
                "name": "Shijun Wen",
                "org": ""
            },
            {
                "name": "Rongbiao Pi",
                "org": ""
            },
            {
                "name": "Wei Shen",
                "org": ""
            }
        ],
        "title": "Carvedilol Attenuates 6-Hydroxydopamine-Induced Cell Death in PC12 Cells: Involvement of Akt and Nrf2/ARE Pathways",
        "abstract": "Oxidative stress is closely related to the pathogenesis of neurodegenerative disorders such as Parkinson\u2019s disease. Carvedilol, a nonselective \u03b2-adrenergic receptor blocker with pleiotropic activity has been shown to exert neuroprotective effect due to its antioxidant property. However, the neuroprotective mechanism of carvedilol is still not fully uncovered. The phosphotidylinositol 3-kinase (PI3K)/Akt signaling pathway plays key role in cell survival and the nuclear factor erythroid 2\u2013related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway is the major cellular defense mechanism against oxidative stress. Here we investigated the effects of carvedilol on 6-hydroxydopamine (6-OHDA)-induced cell death as well as the Akt and Nrf2/ARE pathways in PC12 cells. We found that carvedilol significantly increased cell viability and decreased reactive oxygen species in PC12 cells exposed to 6-OHDA. Furthermore, carvedilol activated the Akt and Nrf2/ARE pathways in a concentration-dependent manner, and increased the protein levels of heme oxygenase-1(HO-1) and NAD(P)H quinone oxidoreductase-1(NQO-1), two downstream factors of the Nrf2/ARE pathway. In summary, our results indicate that carvedilol protects PC12 cells against 6-OHDA-induced neurotoxicity possibly through activating the Akt and Nrf2/ARE signaling pathways.",
        "keywords": [
            "6-Hydroxydopamine",
            "Akt",
            "Carvedilol",
            "Heme oxygenase-1",
            "Nuclear factor E2-related factor 2"
        ],
        "venue": "Neurochemical Research",
        "year": 2014,
        "id": "gR9bhe2u"
    },
    "gQ1stozN": {
        "authors": [
            {
                "name": "Wei Shen",
                "org": "Department of Neurology, Puai Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Lan Wang",
                "org": "Department of Neurology, Puai Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Rongbiao Pi",
                "org": "International Joint Laboratory (SYSU-PolyU HK) of Novel Anti-Dementia Drugs of Guangdong"
            },
            {
                "name": "Zhifeng Li",
                "org": "National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine"
            },
            {
                "name": "Rikang Wang",
                "org": "National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine"
            }
        ],
        "title": "L-F001, a multifunctional ROCK inhibitor prevents paraquat-induced cell death through attenuating ER stress and mitochondrial dysfunction in PC12 cells",
        "abstract": "Abstract Paraquat (PQ) was demonstrated to induce dopaminergic neuron death and is used as a Parkinson's disease (PD) mimetic. Amounting evidences demonstrated that Rho/ROCK may a novel target for the therapy of PD. Previously we synthesized L-F001 and proved it is a potent ROCK inhibitor with multifunctional effects, including anti-oxidative stress. In this study, we investigated the effects and also the molecular mechanisms of L-F001 in preventing PQ-induced cytotoxicity in PC12 cells. L-F001 effectively prevented PQ-induced apoptotic cell death, which involves the scavenger of ROS and also attenuated the declined of mitochondrial membrane potential and intracellular level of GSH induced by PQ. Moreover, PQ quickly induced alterations of GRP78 and CHOP, two hallmarks of endoplasmic reticulum (ER) stress and subsequently induced dysfunction of the mitochondria (such as the decrease in membrane potential and increase in ROS). These changes all were potently attenuated by L-F001. In summary, L-F001 attenuated PQ-induced apoptosis through modulating mitochondrial dysfunction and ER stress as well as the ROS production elicited by PQ. These data indicated that L-F001 could possibly be used to treat PD and other neurodegenerative disorders with similar pathologic mechanisms.",
        "keywords": [
            "Cell death",
            "Endoplasmic reticulum stress",
            "L-F001",
            "Mitochondria",
            "Paraquat",
            "ROCK inhibitor"
        ],
        "venue": "Biochemical and Biophysical Research Communications",
        "year": 2015,
        "id": "gQ1stozN"
    },
    "0OrbIyiC": {
        "authors": [
            {
                "name": "Rikang Wang",
                "org": "National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine"
            },
            {
                "name": "Yongbing Sun",
                "org": "National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine"
            },
            {
                "name": "Hesong Huang",
                "org": "National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine"
            },
            {
                "name": "Lan Wang",
                "org": "Department of Neurology, Puai Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Jinlong Chen",
                "org": "School of Environmental and Chemistry Engineering, Nanchang University"
            },
            {
                "name": "Wei Shen",
                "org": "Department of Neurology, Puai Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            }
        ],
        "title": "Rutin, A Natural Flavonoid Protects PC12 Cells Against Sodium Nitroprusside-Induced Neurotoxicity Through Activating PI3K/Akt/mTOR and ERK1/2 Pathway",
        "abstract": "Free radicals induced neural damage is implicated in CNS diseases and rutin isolated form Lonicera japonica are reported to have neuroprotective activity. Previously, we confirmed that rutin exerted neuroprotective effect against sodium nitroprusside (SNP)-induced cell death in PC12 cells. However, the neuroprotective mechanism of rutin is still not fully uncovered. Here, we found that rutin significantly decreased SNP-induced reactive oxygen species in PC12 cells. Rutin reversed the declined GSH/GSSG ratio and mitochondrial membrane potential induced by SNP. Moreover, rutin activated both the protein Akt/mTOR and the extracellular signal-regulated kinase (ERK1/2) signaling pathways and the neuroprotective effects of rutin were blocked by either the specific PI3K inhibitor LY294002 or the MAPK pathway inhibitor PD98059. In summary, these results demonstrated that the neuroprotective effects of rutin might be through activating both the PI3K/Akt/mTOR and ERK1/2 signaling pathways. Our findings support that rutin may have therapeutic potential for the treatment of CNS diseases related to NO neurotoxicity.",
        "keywords": [
            "Akt/mTOR",
            "Extracellular signal-regulated kinase",
            "PC12 cells",
            "Rutin",
            "Sodium nitroprusside"
        ],
        "venue": "Neurochemical Research",
        "year": 2015,
        "id": "0OrbIyiC"
    },
    "dioSYad8": {
        "authors": [
            {
                "name": "Run-Rong Wang",
                "org": "Department of Radiology, Yangzhou First People\u2019s Hospital of Jiangsu Province"
            },
            {
                "name": "Cheng Li",
                "org": "Department of Radiology, Yangzhou First People\u2019s Hospital of Jiangsu Province"
            },
            {
                "name": "Shuai Zhang",
                "org": "Department of Neurology, Yangzhou First People\u2019s Hospital of Jiangsu Province"
            },
            {
                "name": "Long-Jiang Zhou",
                "org": "Department of Neurology, Yangzhou First People\u2019s Hospital of Jiangsu Province"
            },
            {
                "name": "Ling He",
                "org": "Department of Radiology, Yangzhou First People\u2019s Hospital of Jiangsu Province"
            },
            {
                "name": "Hua-Dong Li",
                "org": "Department of Neurology, Yangzhou First People\u2019s Hospital of Jiangsu Province"
            }
        ],
        "title": "Diffusion tensor imaging change in crus cerebri in striatocapsular infarction and correlation with upper extremity motor dysfunction",
        "abstract": "Purpose: There is limited information about the secondary changes in the pyramidal tract after some specific types of deep brain infarction including striatocapsular infarction. The aims of the current study were to investigate diffusion changes in the crus cerebri in patients with striatocapsular infarction using diffusion tensor imaging (DTI), and analyze the relationship between such changes and upper extremity motor dysfunction. Materials and methods: Fifteen patients with acute onset of striatocapsular infarction and unilateral upper extremity motor dysfunction for the first time were studied prospectively. DTI was performed 2\u00a0weeks after disease onset, fractional anisotropy and mean diffusivity values of the bilateral crus cerebri were measured, the asymmetry indices of bilateral fractional anisotropy were calculated, and the relationship between the asymmetry index value and the Fugl-Meyer assessment score for the affected upper extremity function was evaluated. Results: Two weeks after disease onset, the fractional anisotropy value of the affected crus cerebri was reduced significantly compared with that of the unaffected crus cerebri (0.69 vs. 0.77; p\u00a0<\u00a00.001); there was no significant difference between bilateral mean diffusivity values. After correction for infarct size (448.93\u00a0\u00b1\u00a0227.67\u00a0mm",
        "keywords": [
            "Crus cerebri",
            "Diffusion tensor imaging (DTI)",
            "Striatocapsular infarction",
            "Upper extremity motor function"
        ],
        "venue": "Radiologia Medica",
        "year": 2015,
        "id": "dioSYad8"
    },
    "kXTs33in": {
        "authors": [
            {
                "name": "Jin He",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Lifan Fei",
                "org": "School of Resource and Environment Science"
            }
        ],
        "title": "Mathematical methods involved in constrained reshaping for solving graphic conflicts between streets and buildings",
        "abstract": "On the basis of the new auxiliary hybrid raster-vector data structure and automatic building classification introduced in the previous paper, the mathematical methods involved in the constrained reshaping of the buildings are discussed for maintaining the correct inner-relationships of the buildings, and the right interrelationships between the street and the nearby building symbols, when the multi nearby street symbols are broadened for compilation of maps in smaller scales, and there is no more place for ordinary displacement. The experimental results are shown and their evaluations are given from the aspects of visual and digital analyses.",
        "keywords": [
            "Cartographic displacement",
            "Cartographic generalization",
            "Constrained reshaping",
            "Graphic conflict",
            "Streets and buildings"
        ],
        "venue": "Geomatics and Information Science of Wuhan University",
        "year": 2007,
        "id": "kXTs33in"
    },
    "NQMFRJmK": {
        "authors": [
            {
                "name": "Jin He",
                "org": "School of Resource and Environment"
            },
            {
                "name": "Lifan Fei",
                "org": "School of Resource and Environment Sciences"
            },
            {
                "name": "Lina Huang",
                "org": "School of Resource and Environment Sciences"
            },
            {
                "name": "Yining Liu",
                "org": "Shanghai Surveying and Mapping Institute"
            },
            {
                "name": "Fei Zhao",
                "org": "National Geomatics Center of China"
            }
        ],
        "title": "Study on the method of indirect generalization for contour lines based on the 3D Douglas-Peucker algorithm",
        "abstract": "An indirect generalization method for contour lines is proposed based on the 3D Douglas-Peucker algorithm. Firstly, the source contour lines are taken as the unformatted DEM, i.e., 3D randomly distributed discrete points and are generalized by the 3D Douglas-Peucker algorithm, then the generalized point set can be used as the input of the contour line rendering, finally the rendered contour lines are taken as the result of indirect generalization of contour lines. Preliminary experiments have proved that the contour lines generalized by this method have the geometrical accuracy as well as the topological consistence with the help of major geomorphologic structure lines, and the proposed method has a good adaptability for both input and output contour lines. Therefore, it has a good prospect of application.",
        "keywords": [
            "3D Douglas-Peucker algorithm",
            "Cartographic generalization",
            "Indirect generalization of contour lines",
            "Unformatted DEM"
        ],
        "venue": "Cehui Xuebao/Acta Geodaetica et Cartographica Sinica",
        "year": 2013,
        "id": "NQMFRJmK"
    },
    "0ioSfk7t": {
        "authors": [
            {
                "name": "Jin He",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Lifan Fei",
                "org": "School of Resource and Environment Science"
            }
        ],
        "title": "Three-dimensional Douglas-Peucker algorithm and the study on its application to automated generalization of DEM",
        "abstract": "On the basis of analysis of the principle and nature of the two-dimensional Douglas-Peucker algorithm, this paper puts forward the three-dimensional Douglas-Peucker algorithm and applies this algorithm to the automated generalization of the three-dimensional discrete points or the basis of DEM. The last part of this paper introduces the verification experiments by computer programs for this new algorithm. Preliminary experiments have proved that the main geomorphologic feature points for both the general or local areas of the DEM can be correctly extracted with satisfactory computational efficiency.",
        "keywords": [
            "3-D Douglas-Peucker algorithm",
            "Generalization of 2-D curve",
            "Generalization of 3-D discrete points",
            "Generalization of DEM"
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2006,
        "id": "0ioSfk7t"
    },
    "3zgodSdT": {
        "authors": [
            {
                "name": "Lifan Fei",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Jin He",
                "org": "School of Resource and Environment Science"
            }
        ],
        "title": "Displacement models for solving graphic conflicts between street and buildings",
        "abstract": "This paper discusses the mathematical methods involved in the displacement of the buildings of type 2, 3 and 4 for maintaining the right interrelationships between the street and the nearby building symbols when the ground size of corresponding street symbols are broadened for compilation of maps in smaller scales, and experimental results are given. Finally, a procedure is introduced on the basis of raster detection and vector calculation to detect sequential conflicts after displacement of buildings and a method for removing the sequential conflicts is described.",
        "keywords": [
            "Cartographic displacement",
            "Cartographic generalization",
            "Constrained reshaping",
            "Graphic conflicts",
            "Streets and buildings"
        ],
        "venue": "Geomatics and Information Science of Wuhan University",
        "year": 2007,
        "id": "3zgodSdT"
    },
    "72RIXUDT": {
        "authors": [
            {
                "name": "Li-Fan Fei",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Jin He",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Chen-Yan Ma",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Hui-Wu Yan",
                "org": "Environment Protection Bureau of Taizhou City"
            }
        ],
        "title": "Three dimensional Douglas-Peucker algorithm and the study of its application to automated generalization of DEM",
        "abstract": "On the basis of analysis of the principle and nature of the two dimensional Douglas-Peucker algorithm, this paper puts forward the three dimensional Douglas-Peucker algorithm and applies this algorithm to the automated generalization of the three dimensional discrete points or the basis of DEM. The verification experiments by computer programs for this new algorithm are introduced. Preliminary experiments have proved that the main geomorphologic feature points for both the general or local areas of the DEM can be correctly extracted with satisfactory computational efficiency.",
        "keywords": [
            "3-D Douglas-Peucker algorithm",
            "Douglas-Peucker algorithm",
            "Generalization of 2-D curves",
            "Generalization of 3-D discrete points",
            "Generalization of DEM"
        ],
        "venue": "Acta Geodaetica et Cartographica Sinica",
        "year": 2006,
        "id": "72RIXUDT"
    },
    "7EqVGJcU": {
        "authors": [
            {
                "name": "Jin He",
                "org": "Faculty of Resources and Environmental Science"
            },
            {
                "name": "Rui Yu",
                "org": "Faculty of Resources and Environmental Science"
            },
            {
                "name": "Xinsheng Wang",
                "org": "Faculty of Resources and Environmental Science"
            },
            {
                "name": "Lina Huang",
                "org": "School of Resource and Environmental Science"
            }
        ],
        "title": "Validation of query expression based on regular expression",
        "abstract": "As the technology in GIS and Computer Science develops, more and more applications of GIS have been put into practice. And many general spatial databases has been constructed which are connected with development of social and economy tightly. With complete general spatial databases, the priority of facilitating and improving GIS application is to retrieve data effectively and output data efficiently and accurately. \u00a9 2011 IEEE.",
        "keywords": [
            "Query Expression",
            "Regular Expression",
            "Spatial Data"
        ],
        "venue": "2011 International Conference on Computer Science and Service System, CSSS 2011 - Proceedings",
        "year": 2011,
        "id": "7EqVGJcU"
    },
    "H7jRilPl": {
        "authors": [
            {
                "name": "Xinsheng Wang",
                "org": "School of Resources and Environmental Science"
            },
            {
                "name": "Jin He",
                "org": "School of Resources and Environmental Science"
            },
            {
                "name": "Xiaolei Ye",
                "org": "School of Resources and Environmental Science"
            },
            {
                "name": "Youhua Jiang",
                "org": "School of Civil and Architectural Engineering"
            }
        ],
        "title": "representation and measurement of shape for spatial objects based on spectral method of graph",
        "abstract": "We put forward a new relational matrix, angular matrix. Preliminary research shows that the spectral method of graph is effective for representation and measurement of 2D spatial object's shape and the angular matrix can represent geometric shape of spatial object more accurately and precisely than other relational matrix, such as adjacent matrix, Laplacian matrix, and distance matrix.",
        "keywords": [
            "Angular matrix",
            "Delaunay triangulation",
            "Distance matrix",
            "Relational graph",
            "Spatial object's shape",
            "Spectral method of graph"
        ],
        "venue": "Wuhan Daxue Xuebao (Xinxi Kexue Ban)/Geomatics and Information Science of Wuhan University",
        "year": 2012,
        "id": "H7jRilPl"
    },
    "A2mJEvNe": {
        "authors": [
            {
                "name": "Lifan Fei",
                "org": "School of Resource and Environment Science"
            },
            {
                "name": "Jin He",
                "org": "School of Resource and Environment"
            }
        ],
        "title": "A three-dimensional Douglas-Peucker algorithm and its application to automated generalization of DEMs",
        "abstract": "This article reviews the formation of the 3-D Douglas-Peucker algorithm on the basis of analyzing the nature of the 2-D algorithm and further studies the application of the 3-D method to the automated global generalization of digital elevation model (DEM). Compared to the general 3-D Douglas-Peucker algorithm put forward by the authors in the previous publication, further improvements and expansion of the algorithm have been included in this article, namely, (1) for randomly distributed points, 'loneliness index' of the current point has been taken as the dynamic weight factor of the point-plane distance, so as to improve the selection of the feature points; (2) aiming at the mass volume of the regular square grids, which forms the majority of the DEM data; three measures have been suggested in this article for the improvement of the efficiency of the automated generalization. Experiments have proven that these measures can greatly heighten the efficiency of the DEM generalization with satisfactory results and have offered us the practical possibility of on-the-fly global generalization of DEM with a huge volume of data. \u00a9 2009 Taylor & Francis.",
        "keywords": [
            "3-D Douglas-Peucker algorithm",
            "Generalization of 3-D discrete points",
            "Generalization of DEM",
            "Generalization of RSG"
        ],
        "venue": "International Journal of Geographical Information Science",
        "year": 2009,
        "id": "A2mJEvNe"
    },
    "2WHX6N9s": {
        "authors": [
            {
                "name": "Yan Liu",
                "org": "National Institute of Education"
            },
            {
                "name": "Jin He",
                "org": "School of Resource and Environment"
            }
        ],
        "title": "Developing a web-based cellular automata model for urban growth simulation",
        "abstract": "Cellular automata as an emerging technology have been adapted increasingly by geographers and planners to simulate the spatial and temporal processes of urban growth. While the literature reports many applications of cellular automata models for urban studies, in practice, the operation of the models as well as the configuration and calibration of relevant parameters used in the models were only known to the model builders. This is largely due to the constraint that most cellular automata models were developed based on desktop computer programs, either by incorporating the model within a desktop GIS environment, or developing the model independent of a desktop GIS. Consequently, there is little input from the user to test or visualise the actual operation or evaluate the applicability of the model under different conditions. This paper presents a methodology to implement a fuzzy constrained cellular automata model of urban growth within a web-based GIS environment, using the actual urban growth of Metropolitan Sydney, Australia from 1976 to 2006 as a case study. With the web-based cellular automata model, users can visualise and test the operation of the model; they can also modify or calibrate the model's parameters to evaluate its simulation accuracies, or even feed the model with various 'what-if' conditions to generate alterative outcomes. Such a web-based modelling platform provides a useful and effective channel for government authority and stakeholders to evaluate different urban growth scenarios. It also provides an interactive environment that can foster public participation in urban planning and management. \u00a9 2009 SPIE.",
        "keywords": [
            "Cellular automata",
            "Simulation",
            "Sydney",
            "Urban growth",
            "Web-based GIS"
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2009,
        "id": "2WHX6N9s"
    },
    "fCb3XYpX": {
        "authors": [
            {
                "name": "Jin He",
                "org": "School of Resource and Environment"
            },
            {
                "name": "Lifan Fei",
                "org": "School of Resource and Environment Science"
            }
        ],
        "title": "Further study on three dimensional Douglas-Peucker algorithm and its application to generalization of DEM",
        "abstract": "Compared to the general 3-D Douglas-Peucker algorithm put forward by the authors in the previous publication, further improvements and expansion of the algorithm are discussed. Experimental results prove that these measures can greatly heighten the efficiency of the DEM generalization with satisfactory results, and offere us the practical possibility of on-the-fly global generalization of DEM with huge volume of data.",
        "keywords": [
            "3-D Douglas-Peucker algorithm",
            "Generalization of 3-D discrete points",
            "Generalization of DEM",
            "Generalization of RSG"
        ],
        "venue": "Geomatics and Information Science of Wuhan University",
        "year": 2008,
        "id": "fCb3XYpX"
    },
    "fBPRSVS9": {
        "authors": [
            {
                "name": "Lifan Fei",
                "org": "Fakult\u00e4t der Wissenschaft f\u00fcr Natursch\u00e4tze und Umwelt, Wuhan Universit\u00e4t"
            },
            {
                "name": "Lina Huang",
                "org": "Fakult\u00e4t der Wissenschaft f\u00fcr Natursch\u00e4tze und Umwelt, Wuhan Universit\u00e4t"
            },
            {
                "name": "Jin He",
                "org": "Fakult\u00e4t f\u00fcr Natursch\u00e4tze und Umwelt, Hubei Universit\u00e4t"
            },
            {
                "name": "Qiancong Pang",
                "org": "Fakult\u00e4t f\u00fcr Fernerkundungs- und Informationsingenieur, Wuhan Universit\u00e4t"
            }
        ],
        "title": "City planning in China: Combination of GIS (Geographic Information System) and VR (Virtual Reality) techniques",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "GIS-Business",
        "year": 2008,
        "id": "fBPRSVS9"
    },
    "gls2EXxF": {
        "authors": [
            {
                "name": "Xue Meng",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Billy W. Loo Jr.",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Li Ma",
                "org": "PET/CT Center"
            },
            {
                "name": "James D. Murphy",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Xindong Sun",
                "org": "Department of Radiation Oncology"
            },
            {
                "name": "Jinming Yu",
                "org": "Department of Radiation Oncology"
            }
        ],
        "title": "Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: A pilot study",
        "abstract": "Outcomes are suboptimal when molecularly targeted therapies are used in patient populations unselected for the molecular target. This pilot study examines the correlation of PET using ",
        "keywords": [
            "EGFR",
            "Molecular imaging",
            "NSCLC",
            "PD153035",
            "PET"
        ],
        "venue": "Journal of Nuclear Medicine",
        "year": 2011,
        "id": "gls2EXxF"
    },
    "4GEEUIdj": {
        "authors": [
            {
                "name": "Yue Xu",
                "org": "Graduate University of Chinese Academy of Sciences"
            },
            {
                "name": "Bin Zhao",
                "org": "Tengchong Meteorological Bureau"
            },
            {
                "name": "Dong-Ting Liu",
                "org": "Tengchong Meteorological Bureau"
            },
            {
                "name": "Xiang Liu",
                "org": "State Key Laboratory of Organic Geochemistry"
            },
            {
                "name": "Jun Li",
                "org": "State Key Laboratory of Organic Geochemistry"
            },
            {
                "name": "Gan Zhang",
                "org": "State Key Laboratory of Organic Geochemistry"
            }
        ],
        "title": "Potential sources of polycyclic aromatic hydrocarbons (PAHs) at Tengchong, Southwestern China",
        "abstract": "The concentrations of PAHs in the atmosphere of a typical background site at Tengchong were investigated once a week from October 22nd, 2005 to October 21st, 2006, aimed to monitor the inflow of PAHs originated from Southeast Asian biomass burning during the monsoon season. The total PAHs concentration ranged from 43.1 to 156 ng/m",
        "keywords": [
            "Atmospheric transport",
            "Polycyclic aromatic hydrocarbons (PAHs)",
            "Southeast Asian biomass burning",
            "Tengchong"
        ],
        "venue": "Zhongguo Huanjing Kexue/China Environmental Science",
        "year": 2011,
        "id": "4GEEUIdj"
    },
    "9WxKu1jQ": {
        "authors": [
            {
                "name": "Li Ma",
                "org": ""
            },
            {
                "name": "Xiao-Wei Xie",
                "org": ""
            },
            {
                "name": "Hai-Yan Wang",
                "org": ""
            },
            {
                "name": "Ling-Yun Ma",
                "org": ""
            },
            {
                "name": "Zhong-Guang Wen",
                "org": ""
            }
        ],
        "title": "Clinical evaluation of tumor markers for diagnosis in patients with non-small cell lung cancer in China",
        "abstract": "Background: To evaluate the value of combined detection of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and carbohydrateantigen 125 (CA125) for the clinical diagnosis of non-small cell lung cancer (NSCLC). Materials and Methods: Serum CEA, CYFRA21-1 and CA125 were assessed in 140 patients with NSCLC, 90 patients with benign lung disease and 90 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of NSCLC were analyzed. Results: Serum CEA, CYFRA21-1 and CA125 in patients with NSCLC were significantly higher than those with benign lung disease and normal controls (P < 0.05). The sensitivity of CEA, CYFRA21-1 and CA125 were 49.45%, 59.67%, and 44.87% respectively. As expected, combinations of these tumor markers improved their sensitivity for NSCLC. The combined detection of CEA + CYFRA21-1 was the most cost-effective combination which had higher sensitivity and specificity in NSCLC. Elevation of serum CEA and CYFRA21-1 was significantly associated with pathological types (P < 0.05) and elevation of serum CEA, CYFRA21-1 and CA125 was significantly associated with TNM staging (P < 0.05). Conclusions: Single measurement of CEA, CYFRA21-1 and CA125 is of diagnostic value in the diagnosis of lung cancer, and a joint detection of these three tumor markers, could greatly improve the sensitivity of diagnosis on NSCLC. Combined detection of CEA + CYFRA21-1 proved to be the most economic and practical strategy in diagnosis of NSCLC, which can be used to screen the high-risk group.",
        "keywords": [
            "Diagnosis",
            "Non-small cell lung cancer",
            "Tumor markers"
        ],
        "venue": "Asian Pacific Journal of Cancer Prevention",
        "year": 2015,
        "id": "9WxKu1jQ"
    },
    "jaUIQKjp": {
        "id": "jaUIQKjp",
        "title": "Weight Determination of Sustainable Development Indicators Using a Global Sensitivity Analysis Method",
        "abstract": "Sustainable development (SD) evaluations have attracted considerable attention from governments and scientific communities around the world. The objective and quantitative calculation of the importance of sustainable assessment indicators is a key problem in the accurate evaluation of SD. Traditional methods fail to quantify the coupling effects among indicators. This paper presents a weight determination approach based on the global sensitivity analysis algorithm known as the extended Fourier amplitude sensitivity test (EFAST). This method is efficient and robust and is not only able to quantify the sensitivity of the evaluation indictors to the target, but can also quantitatively describe the uncertainties among the indictors. In this paper, we analyze the sensitivity of 18 indicators in a multi-index comprehensive evaluation model and weigh the indicators in the system according to their importance. To verify the feasibility and advantages of this new method, we compare the evaluation result with the traditional entropy method. The comparison shows that the EFAST algorithm can provide greater detail in an SD evaluation. Additionally, the EFAST algorithm is more specific in terms of quantitative analysis and comprehensive aspects and can more effectively distinguish the importance of indicators.",
        "keywords": "",
        "authors": [
            {
                "name": "Wenfei Luan",
                "org": ""
            },
            {
                "name": "Ling Lu",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Chunfeng Ma",
                "org": ""
            }
        ],
        "venue": "Sustainability",
        "year": 2017
    },
    "zFs9a8zP": {
        "id": "zFs9a8zP",
        "title": "Block Kriging With Measurement Errors: A Case Study of the Spatial Prediction of Soil Moisture in the Middle Reaches of Heihe River Basin.",
        "abstract": "Block kriging (BK) is a common method of predicting the true value at the pixel scale when validating remote sensing retrieval products. However, measurement errors (MEs) increase the prediction uncertainty. In this letter, an extended interpolation technique\u2014BK with MEs (BKMEs)\u2014is developed. The properties of BKME are proven through derivation and demonstrated in a case study of soil moisture (SM) upscaling. Three prediction scenarios\u2014one without MEs (BK), BK with homogeneous MEs (BKHOME), and BK with heterogeneous MEs (BKHEME)\u2014are considered for the upscaling of SM data observed by a distributed wireless sensor network, and the results are compared. Both BK and BKHOME yield the same upscaling results, which differ from those of BKHEME, and the prediction results of BKHEME show less bias than those of the other scenarios. Because both BKHOME and BKHEME consider MEs, their prediction results show smaller kriging variances than do the BK results. Three primary conclusions are drawn. The first is that the optimal kriging coefficients assigned to the observations are affected not only by spatial distance but also by the MEs when the MEs of the samples are unequal. The second is that when the MEs are equal, it may not be necessary to consider the MEs to predict the value for an unobserved location. The third is that although the prediction uncertainty can be reduced by considering MEs, it is more meaningful to consider unequal MEs than equal MEs in the prediction process. BKME is an advanced upscaling method that achieves improved prediction accuracy by considering MEs.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Kang",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Heihe Remote Sensing Experimental Research Station, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Rui Jin",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Heihe Remote Sensing Experimental Research Station, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Xin Li",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Heihe Remote Sensing Experimental Research Station, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Yang Zhang",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Heihe Remote Sensing Experimental Research Station, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China"
            }
        ],
        "venue": "IEEE Geosci. Remote Sensing Lett.",
        "year": 2017
    },
    "w5o75DdG": {
        "id": "w5o75DdG",
        "title": "High spatio-temporal resolution mapping of soil moisture by integrating wireless sensor network observations and MODIS apparent thermal inertia in the Babao River Basin, China",
        "abstract": "Abstract   Soil moisture distributions with high spatio-temporal resolution are scarce but beneficial for understanding eco-hydrological processes and closing the water cycle at the basin scale. Sensor networks are innovative in their ability to capture the spatio-temporal heterogeneity and dynamics of soil moisture; however, they cannot be used to directly derive spatially continuous soil moisture distributions. A Bayesian-based upscaling algorithm that utilizes MODIS-derived apparent thermal inertia is used to map daily soil moisture spatial patterns with a resolution of 1\u00a0km in the Babao River Basin, China. The 2\u20134\u00a0cm soil moisture observations from seven automatic meteorological stations located in different elevation zones from 3000\u00a0m to 3500\u00a0m are employed to validate the mapping algorithm. The correlation coefficient and unbiased root-mean-square error (RMSE) averaged 0.880 and 0.031\u00a0cm 3 /cm 3 , respectively, which indicate satisfactory estimation accuracy. The 1\u00a0km resolution soil moisture products are re-sampled to a resolution of 25\u00a0km and then compared to the level 3 Soil Moisture and Ocean Salinity Mission (SMOS) soil moisture product. The results show that both products exhibit strong temporal consistency; however, due to complex topography, the SMOS soil moisture is generally lower than that of the upscaling results. Semivariograms and an empirical orthogonal function (EOF) analysis are used to analyze the space-time heterogeneities of soil moisture at the 1\u00a0km scale. In the summer, rainfall results in soil moisture with low spatial variability and a complex spatial structure. After the rainy season, the spatial heterogeneity of soil moisture is affected by other factors, such as soil texture, evapotranspiration and topography. From the perspective of temporal variation, the upscaled soil moisture shows a well-defined seasonal cycle, which represents the effects of decreased rainfall from August to October. Because more rain falls in the summer due to the mountain microclimate, the oscillation in soil moisture is more pronounced over 20% of the area compared to that in other regions. Based on a validation analysis of the mapping results, the upscaling method is proven feasible, and the upscaled soil moisture can be used to analyze eco-hydrological processes and validate remote sensing products.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Kang",
                "org": "Heihe Remote Sensing Experimental Research Station, Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Rui Jin",
                "org": "Heihe Remote Sensing Experimental Research Station, Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Xin Li",
                "org": "Heihe Remote Sensing Experimental Research Station, Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China"
            },
            {
                "name": "Chunfeng Ma",
                "org": ""
            },
            {
                "name": "Jun Qin",
                "org": "Laboratory of Tibetan Environment Changes and Land Surface Processes, Institute of Tibetan Plateau Research, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100101, China"
            },
            {
                "name": "Yang Zhang",
                "org": "Heihe Remote Sensing Experimental Research Station, Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China"
            }
        ],
        "venue": "Remote Sensing of Environment",
        "year": 2017
    },
    "HA6Pxxqz": {
        "id": "HA6Pxxqz",
        "title": "Uncertainty Quantification of Soil Moisture Estimations Based on a Bayesian Probabilistic Inversion.",
        "abstract": "Soil moisture (SM) inversions based on active microwave remote sensing have shown promising progress but do not easily meet expected application requirements because a number of inversion algorithms can only produce point estimates of SM and cannot quantify the uncertainty of SM inversions. Although previous studies have reported Bayesian maximum posterior estimations that are capable of retrieving SM within a probabilistic framework, they have primarily focused on the optimal estimators of SM and have typically ignored the uncertainty of SM inversions. This paper presents an SM probabilistic inversion (PI) algorithm based on Bayes\u2019 theorem and the Markov Chain Monte Carlo technique and capable of revealing the uncertainty of SM inversions and obtaining highly accurate SM estimates via maximum likelihood estimations (MLEs). The algorithm is implemented based on the advanced integral equation model, water cloud model simulations, and dual-polarized TerraSAR-X observations. The ground SM and vegetation water content (VWC) measurements from the Heihe watershed allied telemetry experimental research experiments are applied for validation. The results show that: 1) uncertainties in SM inversions, defined with respect to the measures of dispersion of SM posterior probability distribution, are approximately 0.1\u20130.12 m 3 /m 3  and 2) an acceptable inversion accuracy is obtained via MLEs, which present an SM Root Mean Square Error (RMSE) of 0.045 and 0.047 m 3 /m 3  for bare and vegetated soils, respectively, and a VWC RMSE of 0.45 kg/m 2 . The presented PI can quantify the uncertainty in SM inversions; therefore, it should be useful for improving active microwave remote sensing estimations of SM.",
        "keywords": "",
        "authors": [
            {
                "name": "Chunfeng Ma",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Claudia Notarnicola",
                "org": ""
            },
            {
                "name": "Shuguo Wang",
                "org": ""
            },
            {
                "name": "Weizhen Wang",
                "org": ""
            }
        ],
        "venue": "IEEE Trans. Geoscience and Remote Sensing",
        "year": 2017
    },
    "l4uf0jUV": {
        "id": "l4uf0jUV",
        "title": "Spatial Upscaling of Sparse Soil Moisture Observations Based on Ridge Regression.",
        "abstract": "Available ground-based observation networks for the validation of soil moisture remote sensing products are commonly sparse; thus, ground truth determinations are difficult at the validated remote sensing pixel scale. Based on the consistency of temporal trends between ground truth and in situ measurements, it is feasible to estimate ground truth by building a linear relationship between temporal sparse ground observations and truth samples. Herein, auxiliary remote sensing data with a moderate spatial resolution can be transformed into truth samples depending on the stronger representation of remote sensing data to spatial heterogeneity in the validated pixel relative to limited sites. When solving weighting coefficients for the relationship model, the underlying correlations among the in situ measurements cause the multicollinearity problem, leading to failed predictions. An upscaling algorithm called ridge regression (RR) addresses this by introducing a regularization parameter. With sparse sites, the RR method is tested in two cases employing six and nine sites, and compared with the ordinary least squares and the arithmetic mean. The upscaling results of the RR method show higher prediction accuracies compared to the other two methods. When the RR method is used, the six-site case has the same estimation accuracy as the nine-site case due to maintaining the diversity of in situ measurements through the analysis of the ridge trace and variance inflation factor (VIF). Thus, the ridge trace and VIF analysis is considered as the optimal selection method for the existing observation networks if the RR method will be used in future validation work. With a different number of sites, the RR method always displays the best estimation accuracy and is not sensitive to the number of sites, which indicates that the RR method can potentially upscale sparse sites. However, if the sites are too few, e.g., one to four, it is difficult to perform the upscaling method.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Kang",
                "org": ""
            },
            {
                "name": "Rui Jin",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Yang Zhang",
                "org": ""
            },
            {
                "name": "Zhongli Zhu",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2018
    },
    "K3xMJPGt": {
        "id": "K3xMJPGt",
        "title": "A Comprehensive Evaluation of Microwave Emissivity and Brightness Temperature Sensitivities to Soil Parameters Using Qualitative and Quantitative Sensitivity Analyses.",
        "abstract": "Passive microwave remote sensing has experienced significant success for soil moisture (SM) inversion. However, quantifying the uncertainties caused by soil parameter sensitivities has not attracted sufficient attention. Although local sensitivity analysis (SA) has been used to describe parameter sensitivity in the past, it fails to quantify parameter sensitivities, especially interactions, for nonlinear microwave emission models. This paper presents a comprehensive evaluation that combines physically based emission models and various global SA algorithms to evaluate parameter sensitivity. All the algorithms exhibit highly consistent sensitivity measures, which means a reliable SA result is obtained. The results indicate that the sums of the main sensitivity indices of SM and surface roughness parameters\u2014root-mean-square height (RMSH) and correlation length\u2014are greater than 0.92 and 0.95 for emissivity and brightness temperature (TB), respectively. Furthermore, we find that: 1) the parameter probability distributions have little effect on the sensitivity measures; 2) the SM sensitivity decreases and the RMSH sensitivity increases as the frequency increases and the incidence angle decreases; and 3) the SM is more sensitive on V-polarized than on H-polarized emissivity and TB, while the RMSH is much more sensitive on the polarization index. The presented global SA quantitatively explains the optimal frequency, incidence angle, and polarization for SM inversion and extends the parameter SA for microwave emission models to a more general framework, as well as provides an implication for bare soil emission modeling and SM inversion.",
        "keywords": "",
        "authors": [
            {
                "name": "Chunfeng Ma",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources (Cold and Arid Regions Environmental and Engineering Research Institute), Chinese Academy of Sciences, Lanzhou, China"
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Jing Wang",
                "org": ""
            },
            {
                "name": "Chen Wang",
                "org": "College of Global Change and Earth System Science, Beijing Normal University, Beijing, China"
            },
            {
                "name": "Qingyun Duan",
                "org": "College of Global Change and Earth System Science, Beijing Normal University, Beijing, China"
            },
            {
                "name": "Weizhen Wang",
                "org": "Key Laboratory of Remote Sensing of Gansu Province, Northwest Institute of Eco-Environment and Resources (Cold and Arid Regions Environmental and Engineering Research Institute), Chinese Academy of Sciences, Lanzhou, China"
            }
        ],
        "venue": "IEEE Trans. Geoscience and Remote Sensing",
        "year": 2017
    },
    "cjYqMYr1": {
        "id": "cjYqMYr1",
        "title": "Remote sensing products validation activity and observation network in China.",
        "abstract": "Well design and coordinated implementation of validation activity is necessary to evaluate the accuracy of remote sensing product. However, validation is not a straightforward task and remain many challenges. A generally recognized difficult issue is the inconsistence between sparse observations and remote sensing pixels, strong spatial and temporal variations of surface variables, and the intrinsic heterogeneity of land surfaces. Thus, to develop, design and conduct reasonable validation schemes and activities to acquire ground truth at pixel scale over heterogeneous land surfaces is urgently needed. This contains, from the perspective of measurement, integrating various ground observations collected at multi-scale, in order to validate different types of RSPs from site to network, especially for those land surface variables with strong spatial-temporal variations. To this end, a dedicated validation initiative has been launched in China since 2011. The main scientific objectives and research contents are to develop mathematical approaches for spatial sampling optimization to acquire the ground truth at pixel scale over heterogeneous land surfaces, to form a series of recognized and practicable technical specifications to guide validation of various RSPs, and to establish a prototype of national validation network for long term operation. Specific validation activities, such as HiWATER, were conducted from site to network, through multi-scale observations collected from multi-platform and multi-source sensors, to experimentally examine those proposed methodologies and guidelines. Following the experience of these validation exercises, we are coordinating a Chinese validation network to use standardized and recognized technical specifications in implementing future validation attempts, aiming to extend validation exercises from point scale to regional scale and to national scale across different zones.",
        "keywords": "",
        "authors": [
            {
                "name": "Rui Jin",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Mingguo Ma",
                "org": ""
            },
            {
                "name": "Yong Ge",
                "org": ""
            },
            {
                "name": "Tao Che",
                "org": ""
            },
            {
                "name": "Qing Xiao",
                "org": ""
            },
            {
                "name": "Kai Zhao",
                "org": ""
            },
            {
                "name": "Xiaoping Xin",
                "org": ""
            }
        ],
        "venue": "IGARSS",
        "year": 2016
    },
    "T93a4DlX": {
        "id": "T93a4DlX",
        "title": "Multi-Scale Validation of SMAP Soil Moisture Products over Cold and Arid Regions in Northwestern China Using Distributed Ground Observation Data.",
        "abstract": "The Soil Moisture Active Passive (SMAP) mission was designed to provide global mapping of soil moisture (SM) on nested 3, 9, and 36 km earth grids measured by L-band passive and active microwave sensors. The validation of SMAP SM products is crucial for the application of the products and improvement of the retrieval algorithm. Since the SMAP SM products were released, much effort has been invested in the evaluation of the SMAP radiometer SM product (SMAP_P). However, there has been little validation of SMAP radar (SMAP_A) and active/passive combined (SMAP_AP) SM products. This paper presents an evaluation of SMAP_P, SMAP_A and SMAP_AP SM products by using distributed ground observations networks in different landscapes in the Heihe River Basin of northwestern China. The standard error metrics of SMAP products and relative error are applied to measure the products\u2019 performances. The results show that the SMAP SM products exhibit consistent spatial-temporal variation with the ground measurements and typical precipitation events. Three products show various types of performance capability (e.g., active, passive and combined), surface coverage (e.g., bare, vegetated) and climatic region (e.g., cold, arid). Relatively, the SMAP_P shows the best performance, while the SMAP_A performs the worst. The best performances are observed over bare soils but with overestimation and the largest relative error, and unsatisfactory accuracies are observed over cold regions and woody vegetated surfaces with underestimation. The vegetation effect and the freezing-thawing cycle may be major factors that led to an unsatisfactory performance. Efforts on resolving the influence of these factors are expected to improve the accuracy and to promote the application of SMAP SM products over these regions. Overall, this evaluation provides an understanding of SMAP SM products over cold and arid regions, and suggestions for the further refinement of the SMAP SM retrieval algorithms.",
        "keywords": "",
        "authors": [
            {
                "name": "Chunfeng Ma",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Long Wei",
                "org": ""
            },
            {
                "name": "Weizhen Wang",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2017
    },
    "sS4NMsZK": {
        "id": "sS4NMsZK",
        "title": "Development and validation of remote sensing products of hydrological cycle to close water balance at river basin scale.",
        "abstract": "Development and validation of hydrological cycle elements derived from remote sensing observations are of utmost importance for the study of hydrology at different scales, especially at watershed scale. This paper presents the progress we have made in developing and validating watershed scale hydrological cycle products, mainly including precipitation, snow cover area (SCA), soil moisture (SM), evapotranspiration (ET) and groundwater variation. Corresponding high quality remote sensing products (RSPs) have been produced. In addition, to validate the RSPs of water cycle variables, we established several ground observation networks which can provide extensive and high quality validation dataset. Our efforts significantly improve our understanding in watershed water cycle variables, and the developed water cycle products and validation data products have been widely used in several research domains, providing supporting for several key research projects. Based on these efforts, the developed and validated RSPs having been merged into hydrological and land surface models with the aid of land data assimilation method, to allow us to close the water cycle at the basin scale, and further improve our knowledge on terrestrial water study.",
        "keywords": "",
        "authors": [
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Shuguo Wang",
                "org": ""
            },
            {
                "name": "Chunfeng Ma",
                "org": ""
            },
            {
                "name": "Xiaoduo Pan",
                "org": ""
            },
            {
                "name": "Xiaohua Hao",
                "org": ""
            },
            {
                "name": "Rui Jin",
                "org": ""
            },
            {
                "name": "Yangping Cao",
                "org": ""
            },
            {
                "name": "Shaomin Liu",
                "org": ""
            },
            {
                "name": "Chunlin Huang",
                "org": ""
            }
        ],
        "venue": "IGARSS",
        "year": 2016
    },
    "xUFnYaEF": {
        "id": "xUFnYaEF",
        "title": "A preliminary analysis of component polarimetric decomposition towards soil moisture inversion in an oasis of the northwest arid regions of China.",
        "abstract": "The polarimetric synthetic aperture radar (PolSAR) has been demonstrated a huge application potential in soil moisture (SM) inversion under vegetation. However, this promising approach has seldom been reported applied in an oasis of the northwest arid regions of China. This paper presents an analysis of component decomposition based on Radarsat-2 images. The main purpose of the analysis is to provide a preliminary recognition of the scattering mechanisms. The results of the analysis show that the scattering mechanisms in the vegetated oasis are very complex, which implies that scattering mechanisms must be decomposed before SM inversion in a vegetated surface. The analysis provide basis for the SM inversion under vegetation in an oasis of arid regions.",
        "keywords": "",
        "authors": [
            {
                "name": "Chunfeng Ma",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Irena Hajnsek",
                "org": ""
            },
            {
                "name": "Haijing Wang",
                "org": ""
            }
        ],
        "venue": "IGARSS",
        "year": 2016
    },
    "a1YPPkQq": {
        "id": "a1YPPkQq",
        "title": "Reconstruction of MODIS Land Surface Temperature Products Based on Multi-Temporal Information.",
        "abstract": "Land surface temperature (LST) products derived from the moderate resolution imaging spectroradiometer (MODIS) sensor are one of the most important data sources used to research land surface energy and water balance at regional and global scales. However, MODIS data are severely contaminated by cloud cover, which limits the applications of LST products. In this paper, based on the spatio-temporal autocorrelation of land surface variables, a reconstruction algorithm depending on the correlations between spatial pixels in multiple time phases from available MODIS LST data is developed to reconstruct clear-sky LST values for missing pixels. Considering the impacts of correlation and bias between predictors and reconstructed data on the modeling error, the known data in the reconstructed time phase are combined with the data temporally nearest to them as predictor variables to establish their temporal relationships with the reconstructed data. The reconstructed results are validated by a series of evaluation indices. The average correlation coefficient between the reconstructed results and ground-based observations is 0.87, showing high temporal change accuracy. The difference in Moran\u2019s I, representing spatial structure characteristics between the known and reconstructed data, is 0.03 on average, indicating a slight loss of spatial accuracy. The average reconstruction rate is approximately 87.0%. The modeling error, as part of the reconstruction error, is only 1.40 K on average and accounts for 5.0% of the total error. If the product and modeling errors are removed, the residual error represents approximately 3.5 K and 5.6 K of the annual mean difference between the cloudy and cloudless LST at night and during the day, respectively. In addition, different reconstruction cases are demonstrated using various predictor data, including many combinations of multi-temporal MODIS LST data, the microwave brightness temperature, and the combination of the normalized difference vegetation index and terrain data. Comparisons among cases show that the known MODIS LST data are more reliable as predictor variables and that the data combination advocated in this paper is optimal.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Kang",
                "org": ""
            },
            {
                "name": "Junlei Tan",
                "org": ""
            },
            {
                "name": "Rui Jin",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Yang Zhang",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2018
    },
    "qK4MINSZ": {
        "id": "qK4MINSZ",
        "title": "Validation of Regional-Scale Remote Sensing Products in China: From Site to Network.",
        "abstract": "Validation is mandatory to quantify the reliability of remote sensing products (RSPs). However, this process is not straightforward and usually presents formidable challenges in terms of both theory and real-world operations. In this context, a dedicated validation initiative was launched in China, and we identified a validation strategy (VS). This overall VS focuses on validating regional-scale RSPs with a systematic site-to-network concept, consisting of four main components: (1) general guidelines and technical specifications to guide users in validating various land RSPs, particularly aiming to further develop in situ sampling schemes and scaling approaches to acquire ground truth at the pixel scale over heterogeneous surfaces; (2) sound site-based validation activities, conducted through multi-scale, multi-platform, and multi-source observations to experimentally examine and improve the first component; (3) a national validation network to allow for comprehensive assessment of RSPs from site or regional scales to the national scale across various zones; and (4) an operational RSP evaluation system to implement operational validation applications. Research progress on the development of these four components is described in this paper. Some representative research results, with respect to the development of sampling methods and site-based validation activities, are also highlighted. The development of this VS improves our understanding of validation issues, especially to facilitate validating RSPs over heterogeneous land surfaces both at the pixel scale level and the product level.",
        "keywords": "",
        "authors": [
            {
                "name": "Shuguo Wang",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Yong Ge",
                "org": ""
            },
            {
                "name": "Rui Jin",
                "org": ""
            },
            {
                "name": "Mingguo Ma",
                "org": ""
            },
            {
                "name": "Qinhuo Liu",
                "org": ""
            },
            {
                "name": "Jianguang Wen",
                "org": ""
            },
            {
                "name": "Shaomin Liu",
                "org": ""
            }
        ],
        "venue": "Remote Sensing",
        "year": 2016
    },
    "K9LEkWRU": {
        "authors": [
            {
                "name": "Zahida Parveen",
                "org": "School of Life Science and Technology"
            },
            {
                "name": "Liu Yang",
                "org": "School of Life Science and Technology"
            },
            {
                "name": "Yulin Deng",
                "org": "School of Life Science and Technology"
            },
            {
                "name": "Muhammad Khalid Saeed",
                "org": "School of Life Science and Technology"
            },
            {
                "name": "Rongji Dai",
                "org": "School of Life Science and Technology"
            },
            {
                "name": "Hong Yu",
                "org": "School of Life Science and Technology"
            },
            {
                "name": "Waqar Ahamad",
                "org": "School of Life Science and Technology"
            }
        ],
        "title": "Isolation and structure elucidation of the chemical constituents from Thesium chinense Turcz",
        "abstract": "Phytochemical investigation of Thesium chinense Turcz.led to the isolation of seven compounds from the ethyl acetate extract using column chromatography and preparative TLC.The structures of these compounds were identified as, kaempferol-3-O-p-\u03b2-glucopyranosyl (1\u21922)-O-\u03b2-D-6- acetlyglucopyranoside (I), kaempferol-5-methylether (II), Apigenin-5-O- [-L-Rhamnopyranosyl- (1\u21924)-\u03b2-D-glucopyranoside] (III), kaempferol-3-O-glucoside (IV), apigenin -7-O-glucoside (V), kaempferol (VI) and 4\u2032-hydroxy acetophenone (VII) using UV,",
        "keywords": [
            "Flavonoids",
            "Kaempferol",
            "Santalaceae",
            "Thesium chinense Turcz"
        ],
        "venue": "2007 IEEE/ICME International Conference on Complex Medical Engineering, CME 2007",
        "year": 2007,
        "id": "K9LEkWRU"
    },
    "CevhjlAn": {
        "authors": [
            {
                "name": "G. Li",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "J. Ren",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "G. Wang",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "D. Hu",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "G. Gu",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "S. Liu",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "H. Ren",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "X. Wu",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            },
            {
                "name": "J. Li",
                "org": "Department of Surgery, Jinling Hospital, Medical School, Nanjing University"
            }
        ],
        "title": "Preoperative exclusive enteral nutrition reduces the postoperative septic complications of fistulizing Crohn's disease",
        "keywords": [
            ""
        ],
        "venue": "European Journal of Clinical Nutrition",
        "year": 2014,
        "id": "CevhjlAn"
    },
    "MUYteesl": {
        "authors": [
            {
                "name": "S. Liu",
                "org": "Department of General Surgery"
            },
            {
                "name": "J. Ren",
                "org": "Department of General Surgery"
            },
            {
                "name": "G. Gu",
                "org": "Department of General Surgery"
            },
            {
                "name": "Y. Yuan",
                "org": "Department of General Surgery"
            },
            {
                "name": "G. Han",
                "org": "Department of General Surgery"
            },
            {
                "name": "Y. Wu",
                "org": "Department of General Surgery"
            },
            {
                "name": "X. Wu",
                "org": "Department of General Surgery"
            },
            {
                "name": "J. Li",
                "org": "Department of General Surgery"
            }
        ],
        "title": "Drainage of intra-abdominal abscesses with gastrointestinal fistula in Crohn's disease using a sump drain via trocar puncture: A modified strategy",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Techniques in Coloproctology",
        "year": 2013,
        "id": "MUYteesl"
    },
    "ObNIllX5": {
        "authors": [
            {
                "name": "Y. Wu",
                "org": ""
            },
            {
                "name": "J. Ren",
                "org": ""
            },
            {
                "name": "S. Liu",
                "org": ""
            },
            {
                "name": "G. Han",
                "org": ""
            },
            {
                "name": "Y. Zhao",
                "org": ""
            },
            {
                "name": "J. Li",
                "org": ""
            }
        ],
        "title": "Abdominal wall reconstruction by combined use of biological mesh and autogenous pedicled demucosalized small intestinal sheet: A case report",
        "abstract": "Since abdominal wall defects pose a tough challenge to surgeons, methods to solve the problem are attractive. This case report concerns about the combined use of biological mesh and autogenous pedicled demucosalized small intestinal sheet for abdominal wall reconstruction. An 8-month follow-up revealed favorable outcome. Properties that make the method appealing include decreased infection risk, increased strength and viability. It is a novel, safe, and effective method for abdominal wall reconstruction but still requires further studies. \u00a9 Springer-Verlag 2011.",
        "keywords": [
            "Abdominal wall reconstruction",
            "Autogenous pedicled demucosalized small intestinal sheet",
            "Biological mesh",
            "Extensive abdominal defect"
        ],
        "venue": "Hernia",
        "year": 2013,
        "id": "ObNIllX5"
    },
    "gy6uHKaP": {
        "authors": [
            {
                "name": "D. Yan",
                "org": ""
            },
            {
                "name": "J. Ren",
                "org": ""
            },
            {
                "name": "G. Wang",
                "org": ""
            },
            {
                "name": "S. Liu",
                "org": ""
            },
            {
                "name": "J. Li",
                "org": ""
            }
        ],
        "title": "Predictors of response to enteral nutrition in abdominal enterocutaneous fistula patients with Crohn's disease",
        "abstract": "Background/Objectives: Enterocutaneous fistula (ECF) is a serious complication of Crohn's disease (CD). Enteral nutrition (EN) is believed as one of therapeutic strategies of CD. This study is dedicated to identify predictors of response to EN in CD, which may lead to a better selection of fistula patients for this therapy. Subjects/Methods:Forty-eight CD patients with ECF treated with short-peptide-based EN for 3 months were included in this study. All patients were followed up for at least 6 months. Logistic regression was performed to investigate the potential predictors of response to EN in these patients.Results:In total, 30 out of 48 patients were confirmed with a successful closure of fistula after 3 months' EN therapy. The average closure time was 32.4\u00b18.85 days. Inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein (CRP) and platelet count) improved significantly after EN therapy in all enrolled patients. Specifically, the improvement of CRP after therapy in closed group was more important compared with that in unclosed group (P=0.035). Nutrition status (body weight, body mass index (BMI), hemoglobin, serum albumin (ALB), serum prealbumin and total protein (TP)) improved as well (P<0.05). Similarly, after treatment, the improvement of serum albumin (P=0.046) and prealbumin (P=0.006) in closed group was much more important than those in unclosed group. Logistic regression analysis discovered that a decreased CRP level and an elevated BMI level would be beneficial to the response to EN in CD patients with ECF.Conclusions:In CD patients with ECF, lower CRP and higher BMI are associated with higher possibility of closure after EN treatment. EN therapy can lead to a closure of ECF in a certain proportion of patients. EN therapy could also ameliorate inflammatory condition and improve nutrition status. \u00a9 2014 Macmillan Publishers Limited All rights reserved.",
        "keywords": [
            ""
        ],
        "venue": "European Journal of Clinical Nutrition",
        "year": 2014,
        "id": "gy6uHKaP"
    },
    "29iGGX6C": {
        "id": "29iGGX6C",
        "title": "Advances in influence of UV-B radiation on medicinal plant secondary metabolism",
        "abstract": "Stratospheric ozone depletion results in an increased level of solar UV-B radiation (UV-B, 280-320 nm) reaching the earth surface. By the effect of UV-B radiation, various medicinal active ingredients changed because of the change of gene expression, enzyme activity and secondary metabolism, clinical effect is also changed. The research status of UV-B radiation and the accumulation of plant secondary metabolites in the past 10 years were summarized in this paper to supply reference for cultivation and exploitation of the medicinal plants.",
        "keywords": [],
        "authors": [
            {
                "name": "WU Yang",
                "org": "Key Laboratory of Resource Biological and Biotechnology in Western China,College of Life Sciences, Northwest University,Xi\u2032an ,China"
            },
            {
                "name": "FANG Minfeng",
                "org": "Key Laboratory of Resource Biological and Biotechnology in Western China,College of Life Sciences, Northwest University,Xi\u2032an ,China"
            },
            {
                "name": "YUE Ming",
                "org": "Key Laboratory of Resource Biological and Biotechnology in Western China,College of Life Sciences, Northwest University,Xi\u2032an ,China"
            },
            {
                "name": "CHAI Yongfu",
                "org": "Key Laboratory of Resource Biological and Biotechnology in Western China,College of Life Sciences, Northwest University,Xi\u2032an ,China"
            },
            {
                "name": "WANG Hui",
                "org": "Key Laboratory of Resource Biological and Biotechnology in Western China,College of Life Sciences, Northwest University,Xi\u2032an ,China"
            },
            {
                "name": "LI Yifei",
                "org": "Key Laboratory of Resource Biological and Biotechnology in Western China,College of Life Sciences, Northwest University,Xi\u2032an ,China"
            }
        ],
        "venue": "Zhongguo Zhongyao Zazhi",
        "year": 2012
    },
    "lmCfotTt": {
        "id": "lmCfotTt",
        "title": "Review of Studies on Influence of Environmental Factors on Formation of Medicinal Materials from Botanicals",
        "abstract": "Botanicals are the major components of traditional Chinese medicine.One of the most important standards to evaluate the quality of medicinal materials is the concentrations of effective components.Environmental factors play a decisive role in the formation of medicinal materials,suitable growth environment promote synthesis and accumulation of effective components in medicinal material and hence improve its quality.Researches focused on the influence of environmental factors on the quality of medicinal materials over the past 10 years were summarized in this paper.It can be used as reference for building the manufacturing base of medicinal plant resources with high quality.",
        "keywords": [
            "environmental factors",
            "medicinal materials quality",
            "medicinal materials output",
            "botanicals"
        ],
        "authors": [
            {
                "name": "WU Yang",
                "org": " Key Laboratory of Resource Biological and Biotechnology in Western China, College of Life Sciences,Northwest University,Xi'an ,China"
            },
            {
                "name": "WANG Hui",
                "org": " Key Laboratory of Resource Biological and Biotechnology in Western China, College of Life Sciences,Northwest University,Xi'an ,China"
            },
            {
                "name": "FANG Min-feng",
                "org": " Key Laboratory of Resource Biological and Biotechnology in Western China, College of Life Sciences,Northwest University,Xi'an ,China"
            },
            {
                "name": "YUE M",
                "org": " Key Laboratory of Resource Biological and Biotechnology in Western China, College of Life Sciences,Northwest University,Xi'an ,China"
            },
            {
                "name": "LI Yi-fei",
                "org": " Key Laboratory of Resource Biological and Biotechnology in Western China, College of Life Sciences,Northwest University,Xi'an ,China"
            },
            {
                "name": "LI Shan",
                "org": " Key Laboratory of Resource Biological and Biotechnology in Western China, College of Life Sciences,Northwest University,Xi'an ,China"
            }
        ],
        "venue": "Natural Product Research and Development",
        "year": 2013
    },
    "oI7ioZNX": {
        "authors": [
            {
                "name": "C.-J. Chen",
                "org": "Department of Applied Chemistry"
            },
            {
                "name": "Y.-Y. Chu",
                "org": "Department of Applied Chemistry"
            },
            {
                "name": "Y.-Y. Liao",
                "org": "Department of Applied Chemistry"
            },
            {
                "name": "Z.-H. Tsai",
                "org": "Department of Applied Chemistry"
            },
            {
                "name": "C.-C. Wang",
                "org": "Department of Applied Chemistry"
            },
            {
                "name": "K. Chen",
                "org": "Department of Applied Chemistry"
            }
        ],
        "title": "Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction",
        "abstract": "Stereoselective reduction of \u03b1-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (\u2265 96% de) to afford the corresponding \u03b1-hydroxy ester with excellent yields. Change of reducing reagents and molar ratio modifications leading to dramatic changes in diastereofacial selectivity were examined. The auxiliary can be recovered from the asymmetric reaction products without loss of chirality.",
        "keywords": [
            ""
        ],
        "venue": "Tetrahedron Letters",
        "year": 1999,
        "id": "oI7ioZNX"
    },
    "AjD3x7Qw": {
        "authors": [
            {
                "name": "K.C. Chao",
                "org": ""
            },
            {
                "name": "D.K. Rayabarapu",
                "org": ""
            },
            {
                "name": "C.-C. Wang",
                "org": ""
            },
            {
                "name": "C.-H. Cheng",
                "org": ""
            }
        ],
        "title": "Cross [2 + 2] cycloaddition of bicyclic alkenes with alkynes mediated by cobalt complexes: A facile synthesis of cyclobutene derivatives",
        "abstract": "Bicyclic alkenes 1a-e and 5 undergo [2 + 2] cycloaddition with a variety of alkynes PhC\u2261CPh, (TMS)C\u2261CH, HC\u2261C(CH",
        "keywords": [
            ""
        ],
        "venue": "Journal of Organic Chemistry",
        "year": 2001,
        "id": "AjD3x7Qw"
    },
    "q9gNkPwE": {
        "authors": [
            {
                "name": "X.Z. Zhang",
                "org": "School of Life Sciences, Shandong University of Technology"
            },
            {
                "name": "T. Wang",
                "org": "Department of Chemistry and Chemical Engineering, Liaoning Normal University"
            },
            {
                "name": "X.F. Chen",
                "org": "School of Life Sciences, Shandong University of Technology"
            },
            {
                "name": "J. Li",
                "org": "School of Life Sciences, Shandong University of Technology"
            },
            {
                "name": "H.H. Li",
                "org": "Department of Chemistry and Chemical Engineering, Liaoning Normal University"
            },
            {
                "name": "Z.L. You",
                "org": "Department of Chemistry and Chemical Engineering, Liaoning Normal University"
            },
            {
                "name": "H.L. Zhu",
                "org": "Department of Chemistry and Chemical Engineering, Liaoning Normal University"
            }
        ],
        "title": "Synthesis and X-ray structures of di- and mono-nuclear oxovanadium(V) complexes derived from aroylhydrazones",
        "abstract": "A new methanolato-bridged dinuclear oxovanadium(V) complex [VO(L)(OMe)]<inf>2</inf> (I) derived from N'-(2-hydroxy-5-methylbenzylidene)-2-methylbenzohydrazide (H<inf>2</inf>L) and a new mononuclear oxovanadium(V) complex [VO(L')(OMe)(MeOH)] (II) derived from 3-chloro-N'-(2-hydroxy-3-methylbenzylidene)benzohydrazide (H<inf>2</inf>L') were prepared and characterized by infrared spectra and single crystal X-ray determination (CIF files CCDC nos. 974793 (I) and 974792 (II)). Complex I crystallizes as triclinic space group P $$\\overline 1 $$ with unit cell dimensions a = 8.5063(4), b = 9.5367(4), c = 11.2445(5) \u00c5, \u03b1 = 71.740(1)\u00b0, \u03b2 = 72.341(1)\u00b0, \u03b3 = 74.509(1)\u00b0, V = 810.37(6) \u00c5<sup>3</sup>, Z = 1, R <inf>1</inf> = 0.0527, wR <inf>2</inf> = 0.1316, S = 0.969. The complex possesses a crystallographic inversion center symmetry between two V atoms. Complex II crystallizes as triclinic space group P $$\\overline 1 $$ with unit cell dimensions a = 7.4257(3), b = 9.9475(4), c = 13.1021(5) \u00c5, \u03b1 = 71.954(1)\u00b0, \u03b2 = 85.657(1)\u00b0, \u03b3 = 84.127(1)\u00b0, V = 914.38(6) \u00c5<sup>3</sup>, Z = 2, R <inf>1</inf> = 0.0365, wR <inf>2</inf> = 0.0957, S = 1.039. The tridentate aroylhydrazone ligands coordinate to the V center through azomethine nitrogen, phenolate oxygen, and enolate oxygen. The V atoms in the complexes are in octahedral coordination. Crystal structures of the complexes are stabilized by hydrogen bonds and \u03c0\u00b7\u00b7\u00b7\u03c0 interactions.",
        "keywords": [
            ""
        ],
        "venue": "Russian Journal of Coordination Chemistry/Koordinatsionnaya Khimiya",
        "year": 2015,
        "id": "q9gNkPwE"
    },
    "F77FECKP": {
        "authors": [
            {
                "name": "Xiao-Li Zhang",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Xiao-Xu Han",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Di Dai",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Xi-Hua Dong",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Ming-Jia Bao",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Bin Zhao",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Yong-Jun Jiang",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Ya-Nan Wang",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Zi-Ning Zhang",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Li-Ping Zhou",
                "org": "Key Laboratory of Immunology of AIDS"
            },
            {
                "name": "Hong Shang",
                "org": "Key Laboratory of Immunology of AIDS"
            }
        ],
        "title": "Amino acid mutations of gp41 2F5 and 4E10 neutralizing epitopes of 92 HIV-1 infected individuals and AIDS patients in China",
        "abstract": "Objective: To study the amino acid mutations in neutralizing antibody 2F5 and 4E10 conserved epitopes ELDKWA and NWFDIT of HIV-1 membrane proximal external region (MPER) in 92 HIV-infected individuals and AIDS patients in China, and to provide a basis for the neutralizing antibodies immunotherapy and a design of vaccines. Methods: Nest-PCR methods were used to amplify genes of the HIV-1 env gp41 region. The amplified fragments were sequenced by double-deoxygen terminal method and translated into amino acids for analysis. The mutations of 2F5 and 4E10 neutralizing epitopes were identified by comparison with the epitopes reference data in HIV-1 Sequence Database. Results: There were mutations on both 2F5 and 4E10 neutralizing epitopes. 2F5 conserved neutralizing epitopes major mutations focused on E662A (14.1%), K665S (17.4%), A667K (16.3%), and 4E10 conserved neutralizing epitopes major mutations included N671S (13.0%), D674S(3.3%), T676S(16.3%). The mutation rates of 2F5 and 4E10 epitopes were significandy different between CRF_B'C-clade and B'-clade (P<0.05). The mutation rates of CRF_B'C-clade were higher than that of CRF01_AE-clade in 2F5 epitopes (P <0.05). The mutation rates of B'-clade in 4E10 eiptopes showed significant difference in slow progressors, HIV-infected individuals and AIDS patients, respectively (P<0.05). Conclusion: The HIV-1 patients in China are demonstrated diversified mutations in 2F5 and 4E10 neutralizing epitopes. The mutation degrees of amino acids in conserved neutralizing epitopes are different in different subtypes. There may be a correlation between neutralizing epitopes mutations of 4E10 with disease progression.",
        "keywords": [
            "2F5",
            "4E10",
            "Gp41",
            "HIV-1",
            "Neutralizing epitope"
        ],
        "venue": "Chinese Journal of Microbiology and Immunology",
        "year": 2008,
        "id": "F77FECKP"
    },
    "rE2eXFQP": {
        "authors": [
            {
                "name": "Qin Kuang",
                "org": ""
            },
            {
                "name": "Xue Wang",
                "org": ""
            },
            {
                "name": "Zhiyuan Jiang",
                "org": ""
            },
            {
                "name": "Zhaoxiong Xie",
                "org": ""
            },
            {
                "name": "Lansun Zheng",
                "org": ""
            }
        ],
        "title": "High-energy-surface engineered metal oxide micro- and nanocrystallites and their applications",
        "abstract": "Because many physical and chemical processes occur at surfaces, surface atomic structure is a critical factor affecting the properties of materials. Due to the presence of high-density atomic steps and edges and abundant unsaturated coordination sites, micro- and nanocrystallites with high-energy surfaces usually exhibit greater reactivity than those with low-energy surfaces. However, high-energy crystal surfaces are usually lost during crystal growth as the total surface energy is minimized. Therefore, the selective exposure of high-energy facets at the surface of micro- and nanocrystallites is an important and challenging research topic. Metal oxides play important roles in surface-associated applications, including catalysis, gas sensing, luminescence, and antibiosis. The synthesis of metal oxide micro- and nanocrystallites with specific surfaces, particularly those with high surface energies, is more challenging than the synthesis of metal crystals due to the presence of strong metal-oxygen bonds and diverse crystal structures.In this Account, we briefly summarize recent progress in the surface-structure-controlled synthesis of several typical metal oxide micro- and nanocrystallites, including wurtzite ZnO, anatase TiO",
        "keywords": [
            ""
        ],
        "venue": "Accounts of Chemical Research",
        "year": 2014,
        "id": "rE2eXFQP"
    },
    "vYKymqxr": {
        "authors": [
            {
                "name": "Xue Wang",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces"
            },
            {
                "name": "Madeline Vara",
                "org": "School of Chemistry and Biochemistry"
            },
            {
                "name": "Ming Luo",
                "org": "Wallace H. Coulter Department of Biomedical Engineering"
            },
            {
                "name": "Hongwen Huang",
                "org": "Wallace H. Coulter Department of Biomedical Engineering"
            },
            {
                "name": "Aleksey Ruditskiy",
                "org": "School of Chemistry and Biochemistry"
            },
            {
                "name": "Jinho Park",
                "org": "School of Chemistry and Biochemistry"
            },
            {
                "name": "Shixiong Bao",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces"
            },
            {
                "name": "Jingyue Liu",
                "org": "Department of Physics"
            },
            {
                "name": "Jane Howe",
                "org": "Hitachi High-Technologies Canada"
            },
            {
                "name": "Miaofang Chi",
                "org": "Center for Nanophase Materials Sciences"
            },
            {
                "name": "Zhaoxiong Xie",
                "org": "State Key Laboratory of Physical Chemistry of Solid Surfaces"
            },
            {
                "name": "Younan Xia",
                "org": "School of Chemistry and Biochemistry"
            }
        ],
        "title": "Pd@Pt Core-Shell Concave Decahedra: A Class of Catalysts for the Oxygen Reduction Reaction with Enhanced Activity and Durability",
        "abstract": "We report a facile synthesis of multiply twinned Pd@Pt core-shell concave decahedra by controlling the deposition of Pt on preformed Pd decahedral seeds. The Pt atoms are initially deposited on the vertices of a decahedral seed, followed by surface diffusion to other regions along the edges/ridges and then across the faces. Different from the coating of a Pd icosahedral seed, the Pt atoms prefer to stay at the vertices and edges/ridges of a decahedral seed even when the deposition is conducted at 200\u00b0C, naturally generating a core-shell structure covered by concave facets. The nonuniformity in the Pt coating can be attributed to the presence of twin boundaries at the vertices, as well as the {100} facets and twin defects along the edges/ridges of a decahedron, effectively trapping the Pt adatoms at these high-energy sites. As compared to a commercial Pt/C catalyst, the Pd@Pt concave decahedra show substantial enhancement in both catalytic activity and durability toward the oxygen reduction reaction (ORR). For the concave decahedra with 29.6% Pt by weight, their specific (1.66 mA/cm",
        "keywords": [
            ""
        ],
        "venue": "Journal of the American Chemical Society",
        "year": 2015,
        "id": "vYKymqxr"
    },
    "7rj6VOmb": {
        "authors": [
            {
                "name": "Junwu Xiao",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Lian Wan",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Xue Wang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Qin Kuang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shuang Dong",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Fei Xiao",
                "org": "College of Chemistry and Chemical Engineering"
            },
            {
                "name": "Shuai Wang",
                "org": "College of Chemistry and Chemical Engineering"
            }
        ],
        "title": "Mesoporous Mn3O4-CoO core-shell spheres wrapped by carbon nanotubes: A high performance catalyst for the oxygen reduction reaction and CO oxidation",
        "keywords": [
            ""
        ],
        "venue": "Journal of Materials Chemistry A",
        "year": 2014,
        "id": "7rj6VOmb"
    },
    "00HSyAsr": {
        "authors": [
            {
                "name": "Li Ma",
                "org": "Department of Preventive and Pediatric Dentistry"
            },
            {
                "name": "Qinfeng Ding",
                "org": "Department of Preventive and Pediatric Dentistry"
            },
            {
                "name": "Xiping Feng",
                "org": "Department of Preventive and Pediatric Dentistry"
            },
            {
                "name": "Fei Li",
                "org": "Department of Preventive and Pediatric Dentistry"
            }
        ],
        "title": "The protective effect of recombinant FomA-expressing Lactobacillus acidophilus against periodontal infection",
        "abstract": "A number of studies have shown that the outer membrane protein FomA found in Fusobacterium nucleatum demonstrates great potential as an immune target for combating periodontitis. Lactobacillus acidophilus is a useful antigen delivery vehicle for mucosal immunisation, and previous studies by our group have shown that L. acidophilus acts as a protective factor in periodontal health. In this study, making use of the immunogenicity of FomA and the probiotic properties of L. acidophilus, we constructed a recombinant form of L. acidophilus expressing the FomA protein and detected the FomA-specific IgG in the serum and sIgA in the saliva of mice through oral administration with the recombinant strains. When serum containing FomA-specific antibodies was incubated with the F. nucleatum in vitro, the number of Porphyromonas gingivalis cells that coaggregated with the F. nucleatum cells was significantly reduced. Furthermore, a mouse gum abscess model was successfully generated, and the range of gingival abscesses in the immune mice was relatively limited compared with the control group. The level of IL-1\u03b2 in the serum and local gum tissues of the immune mice was consistently lower than in the control group. Our findings indicated that oral administration of the recombinant L. acidophilus reduced the risk of periodontal infection with P. gingivalis and F. nucleatum. \u00a9 2013 The Author(s).",
        "keywords": [
            "FomA",
            "Fusobacterium nucleatum",
            "Lactobacillus acidophilus",
            "periodontal infection",
            "Porphyromonas gingivalis"
        ],
        "venue": "Inflammation",
        "year": 2013,
        "id": "00HSyAsr"
    },
    "s4qBK6me": {
        "id": "s4qBK6me",
        "title": "A polymorphism within the mismatch repair gene predicts prognosis and adjuvant chemotherapy benefit in gastric cancer patients.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Deqiang Wang",
                "org": "Department of Medical Oncology, Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, China;"
            },
            {
                "name": "Deyu Chen",
                "org": "Department of Radiotherapy, Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, China;"
            },
            {
                "name": "Bo Shen",
                "org": "Department of Medical Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, P.R. China, Nanjing, China;"
            },
            {
                "name": "Xiaofeng Chen",
                "org": "Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;"
            },
            {
                "name": "Mingzhe Xiao",
                "org": "The Medical Department, 3D Medicines Inc., Shanghai, P.R. China, Shanghai, China;"
            },
            {
                "name": "Xiaoqin Li",
                "org": "Department of Medical Oncology, Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, China;"
            },
            {
                "name": "Yongqian Shu",
                "org": "Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P.R. China, Nanjing, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2019
    },
    "r83rRj6Q": {
        "id": "r83rRj6Q",
        "title": "A polymorphism within the mismatch repair gene predicts prognosis and adjuvant chemotherapy benefit in gastric cancer.",
        "abstract": "The rs2303428 genotypes may predict prognosis and adjuvant chemotherapy benefit in non-cardia GC patients.",
        "keywords": [
            "Adjuvant chemotherapy",
            "Gastric cancer",
            "Microsatellite instability",
            "Mismatch repair",
            "Polymorphism"
        ],
        "authors": [
            {
                "name": "Xiaohui Zhao",
                "org": "Department of Pathology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China."
            },
            {
                "name": "Dongfang Dai",
                "org": "Department of Medical Oncology, The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Road Jiefang, Zhenjiang, 212001, Jiangsu, China."
            },
            {
                "name": "Xiaoqin Li",
                "org": "Department of Medical Oncology, The Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Road Jiefang, Zhenjiang, 212001, Jiangsu, China."
            },
            {
                "name": "Bo Shen",
                "org": "Department of Medical Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China."
            },
            {
                "name": "Xiaofeng Chen",
                "org": "Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Road Guangzhou, Nanjing, 210029, China."
            },
            {
                "name": "Yongqian Shu",
                "org": "Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Road Guangzhou, Nanjing, 210029, China. shuyongqian@csco.org.cn."
            },
            {
                "name": "Deqiang Wang",
                "org": "Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Road Guangzhou, Nanjing, 210029, China. deqiang_wang@aliyun.com."
            }
        ],
        "venue": "Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association",
        "year": 2019
    },
    "Jg7lyCNU": {
        "id": "Jg7lyCNU",
        "title": "Histone chaperone CHAF1A impacts the outcome of fluoropyrimidines-based adjuvant therapy in gastric cancer by regulating the expression of thymidylate synthetase.",
        "abstract": "CHAF1A may impact adjuvant chemotherapy outcome of GC by regulating the expression of TS.",
        "keywords": [
            "CHAF1A",
            "Chemotherapy",
            "Gastric cancer",
            "Thymidylate synthetase"
        ],
        "authors": [
            {
                "name": "Deqiang Wang",
                "org": "Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road, Nanjing 210029, China; Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Jiefang Road, Zhenjiang 212001, China."
            },
            {
                "name": "Xiaoqin Li",
                "org": "Department of Medical Oncology, Affiliated Hospital of Jiangsu University, Jiefang Road, Zhenjiang 212001, China."
            },
            {
                "name": "Bo Shen",
                "org": "Department of Medical Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting Road, Nanjing 210009, China."
            },
            {
                "name": "Xiaofeng Chen",
                "org": "Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road, Nanjing 210029, China."
            },
            {
                "name": "Yongqian Shu",
                "org": "Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road, Nanjing 210029, China. Electronic address: yongqian_shu@sina.com."
            }
        ],
        "venue": "Gene",
        "year": 2019
    },
    "Rhe4INk5": {
        "id": "Rhe4INk5",
        "title": "Correlation of CHAF1A with adjuvant chemotherapy outcome and microsatellite instability in gastric cancer.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Deqiang Wang",
                "org": "Department of Medical Oncology, Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, China;"
            },
            {
                "name": "Deyu Chen",
                "org": "Department of Radiotherapy, Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, China;"
            },
            {
                "name": "Bo Shen",
                "org": "Internal Medicine-Oncology, Jiangsu Cancer Hospital, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China;"
            },
            {
                "name": "Xiaofeng Chen",
                "org": "Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;"
            },
            {
                "name": "Martin Qi",
                "org": "The Medical Department, 3D Medicines Inc., Shanghai, China;"
            },
            {
                "name": "Xiaoqin Li",
                "org": "Department of Medical Oncology, Cancer Therapy Center, Affiliated Hospital of Jiangsu University, Zhenjiang, China;"
            },
            {
                "name": "Yongqian Shu",
                "org": "Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;"
            }
        ],
        "venue": "Journal of Clinical Oncology",
        "year": 2019
    },
    "DTJlCWrY": {
        "authors": [
            {
                "name": "Zhaoxia Wu",
                "org": "College of Food Science, Shenyang Agricultural University"
            },
            {
                "name": "Liu Yang",
                "org": "Foreign Language Teaching Department, Shenyang Agricultural University"
            },
            {
                "name": "Suijing Li",
                "org": "Department of Nutrition and Food Safety and School Health, Liaoning Provincial Center for Disease Control and Prevention"
            },
            {
                "name": "Wei Chen",
                "org": "College of Food Science, Shenyang Agricultural University"
            },
            {
                "name": "Donghua Jiang",
                "org": "College of Food Science, Shenyang Agricultural University"
            },
            {
                "name": "Yanqun Wang",
                "org": "College of Food Science, Shenyang Agricultural University"
            },
            {
                "name": "Qi Zhang",
                "org": "College of Food Science, Shenyang Agricultural University"
            },
            {
                "name": "Xuan Zhang",
                "org": "College of Food Science, Shenyang Agricultural University"
            }
        ],
        "title": "Flavonoids intake estimation of urban and rural residents in Liaoning Province",
        "abstract": "Flavonoids, a class of vital phytochemicals, are commonly found in fruits, vegetables, soybean and soybean products. It's necessary to assessment the flavonoids intake when consideration of the relationship between flavonoids and health. This study is intended to estimate the overall flavonoids intake of urban and rural residents in Liaoning Province based on the Nutritional Survey in 2009 in Liaoning Province. The results showed that flavonoids could be detected in all foodstuffs with contents ranged from 1.37 \u00b1 0.59 mg/100g to 237 \u00b1 1.29 mg/100g. Among the vegetables detected, soybean and soybean products, and leaf vegetables had higher flavonoids contents. There is no difference between urban and rural residents in terms of vegetable consumption with the data of 365.6g and 361.5g respectively. However, compared to urban residents, rural residents consumed less fruits, with only 147.3g, while the urban 171.4 g. The flavonoids intake by the urban residents reached 188.79 mg, and the rural 166.20 mg. The dominant reason for this difference attributed to the fact that urban residents consumed more soybean and soybean products than rural residents. \u00a9 2014 Taylor & Francis Group.",
        "keywords": [
            ""
        ],
        "venue": "Advanced Engineering and Technology - Proceedings of the 2014 Annual Congress on Advanced Engineering and Technology, CAET 2014",
        "year": 2014,
        "id": "DTJlCWrY"
    },
    "6e3rj2JE": {
        "authors": [
            {
                "name": "Q.B. Zhang",
                "org": "Key Laboratory of Ionic Liquids Metallurgy, Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology"
            },
            {
                "name": "Andrew P. Abbott",
                "org": "Department of Chemistry, University of Leicester"
            },
            {
                "name": "C. Yang",
                "org": "Key Laboratory of Ionic Liquids Metallurgy, Faculty of Metallurgical and Energy Engineering, Kunming University of Science and Technology"
            }
        ],
        "title": "Electrochemical fabrication of nanoporous copper films in choline chloride-urea deep eutectic solvent",
        "abstract": "Nanoporous copper films were fabricated by a facile electrochemical alloying/dealloying process without the need of a template. A deep eutectic solvent made from choline chloride (ChCl) and urea was used with zinc oxide as the metal salt. Cyclic voltammetry was used to characterise the electrochemical reduction of zinc and follow Cu-Zn alloy formation on the copper substrate at elevated temperatures from 353 to 393 K. The alloy formation was confirmed by X-ray diffraction spectra. 3D, open and bicontinuous nanoporous copper films were obtained by in situ electrochemically etching (dealloying) of the zinc component in the Cu-Zn surface alloys at an appropriate potential (-0.4 V vs. Ag). This dealloying process was found to be highly temperature dependent and surface diffusion controlled, which involved the self-assembly of copper atoms at the alloy/electrolyte interface. Additionally, the effects of the deposition parameters, including deposition temperature, current density as well as total charge density on resulting the microstructure were investigated by scanning electron microscopy, and atomic force microscope.",
        "keywords": [
            ""
        ],
        "venue": "Physical Chemistry Chemical Physics",
        "year": 2015,
        "id": "6e3rj2JE"
    },
    "XCdJ2iSW": {
        "id": "XCdJ2iSW",
        "title": "Ki-67 Index as a Prognostic Marker in Chordomas: A Systematic Review of the Literature",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xiao-Bin Wang",
                "org": ""
            },
            {
                "name": "Guohua Lv",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Ming-Xiang Zou",
                "org": ""
            }
        ],
        "venue": "World Neurosurgery",
        "year": 2017
    },
    "K96xBC2B": {
        "id": "K96xBC2B",
        "title": "Prognostic factors in spinal chordoma: An update of current systematic review and meta-analysis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": ""
            },
            {
                "name": "Guohua Lv",
                "org": ""
            },
            {
                "name": "Xiao-Bin Wang",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            }
        ],
        "venue": "Journal of Surgical Oncology",
        "year": 2017
    },
    "zbIxNj0I": {
        "id": "zbIxNj0I",
        "title": "Letter to the Editor concerning \"Surgical treatment of sacral chordoma: survival and prognostic factors\" by C. Ruosi et al. (Eur Spine J; 2015; 24(Suppl 7):S912-S917.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Guohua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            }
        ],
        "venue": "European Spine Journal",
        "year": 2017
    },
    "CHjxL7BT": {
        "id": "CHjxL7BT",
        "title": "Giant ganglion cell tumor associated with thoracolumbar scoliosis.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2016
    },
    "sSwptUui": {
        "id": "sSwptUui",
        "title": "Acute cauda equina syndrome secondary to chondromyxoid fibroma of the lumbar spine.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan410011, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan410011, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan410011, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No. 139, Middle of Renmin Rd, Changsha, Hunan410011, China."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2016
    },
    "Pho2pqBq": {
        "id": "Pho2pqBq",
        "title": "Infiltrative low-grade fibromyxoid sarcoma of the thoracic spine.",
        "abstract": "A 25-year-old man presented with a 1-year history of recurrent thoracic back pain. Physical examination revealed a mild hypoesthesia of both lower extremities. Computed tomography scan showed an expansile lytic lesion involving the vertebral bodies as well as the posterior elements at the T1\u2013 T3 levels (Fig. 1, Left), which was confirmed to be extending into the right ribs on axial computed tomography image (Fig. 1, Right). Magnetic resonance imaging revealed a large multiloculated lesion measuring 13\u00d710.8\u00d74.7 cm, with high vascularization within the paraspinal soft tissues at the level of T1\u2013T3 accompanied with associated intraspinal extension (Fig. 2). Complete resection of the mass lesion was performed by a posterior approach with instrumentation. Postoperative period was uneventful. Pathologic examination and immunohistochemical staining confirmed the diagnosis of lowgrade fibromyxoid sarcoma. Low-grade fibromyxoid sarcoma is a rare mesenchymal malignancy with a deceptively bland histologic appearance but showing potential for late recurrence and metastasis [1,2]. Low-grade fibromyxoid sarcoma occurs most commonly in the deep soft tissues of proximal extremities, and also in the inguinal area, neck, or chest wall [2,3]. Spinal involvement with low-grade fibromyxoid sarcoma has rarely been reported [3,4].",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2016
    },
    "7DQT8fz9": {
        "id": "7DQT8fz9",
        "title": "Letter to the Editor: Influence of age on survival outcomes in patients with spinal chordoma",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Xiao-Bin Wang",
                "org": ""
            },
            {
                "name": "Guohua Lv",
                "org": ""
            }
        ],
        "venue": "Journal of Neurosurgery",
        "year": 2017
    },
    "AxD2OHXB": {
        "id": "AxD2OHXB",
        "title": "Letter to the Editor. Brachyury as prognostic biomarker in chordoma.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hua Zhong",
                "org": "Central Hospital of Yi Yang, Yiyang, China; and."
            },
            {
                "name": "Zhihong Zhou",
                "org": "Central Hospital of Yi Yang, Yiyang, China; and."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Jing Li",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Ming-Xiang Zou",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            }
        ],
        "venue": "Journal of neurosurgery",
        "year": 2018
    },
    "G7Arc5t5": {
        "id": "G7Arc5t5",
        "title": "Expression of programmed death-1 ligand (PD-L1) in tumor-infiltrating lymphocytes is associated with favorable spinal chordoma prognosis.",
        "abstract": "Aberrant expression of programmed death-1 (PD-1) receptor/PD-1 ligand (PD-L1) proteins alters human immunoresponse and promotes tumor development and progression. We assessed the expression status of PD-1 and PD-L1 in spinal chordoma tissue specimens and their association with clinicopathological characteristics of patients. Formalin-fixed paraffin-embedded tumor samples from 54 patients with spinal chordoma were collected for immunohistochemical analysis of PD-1 and PD-L1 expression. The association of the expression levels of PD-1 and PD-L1 with clinicopathological variables and survival data were statistically analyzed. Lymphocyte infiltrates were present in all 54 patient samples. Of 54 samples, 37 (68.5%) had both positive PD-1 and PD-L1 expression in tumor cell membrane. Moreover, 38 (70.4%) and 12 (22.2%) had positive PD-1 and PD-L1 expression in tumor-infiltrating lymphocytes (TILs), respectively. Tumors with positive PD-L1 expression were significantly associated with advanced stages of chordoma (p = 0.041) and TIL infiltration (p = 0.005), and had a borderline association with tumor grade (p = 0.051). However, positive tumor PD-L1 expression was not significantly associated with local recurrence-free survival (LRFS) or overall survival (OS). PD-1 expression in TILs was associated with poor LRFS (\u03c7(2) = 10.051, p = 0.002, log-rank test). Multivariate analysis showed that PD-L1 expression only in TILs was an independent predictor for LRFS (HR = 0.298, 95% CI: 0.098-0.907, p = 0.033), and OS (HR = 0.188, 95% CI: 0.051-0.687, p = 0.011) in spinal chordoma patients. In conclusion, PD-L1 expression in TILs was an independent predictor for both LRFS and OS in spinal chordoma patients. Our findings suggest that the PD-1/PD-L1 pathway may be a novel therapeutic target for the immunotherapy of chordoma. ",
        "keywords": [
            "PD-1",
            "PD-L1",
            "Spinal chordoma",
            "prognosis",
            "tumor-infiltrating lymphocytes"
        ],
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            },
            {
                "name": "An-Bo Peng",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            },
            {
                "name": "Xiao-Ling She",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            },
            {
                "name": "Yi Jiang",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, China."
            }
        ],
        "venue": "American journal of translational research",
        "year": 2016
    },
    "H9gDIM5u": {
        "id": "H9gDIM5u",
        "title": "Letter: Cranial Chordoma: A New Preoperative Grading System.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha, China."
            },
            {
                "name": "Fu-Sheng Liu",
                "org": "Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery The Second Xiangya Hospital Central South University Changsha, China."
            }
        ],
        "venue": "Neurosurgery",
        "year": 2018
    },
    "YsjfCtAL": {
        "id": "YsjfCtAL",
        "title": "Letter to the Editor. Prognostic factors in skull base chordoma.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Jing Li",
                "org": "The Second Xiangya Hospital, Central South University, Changsha, China."
            }
        ],
        "venue": "Journal of neurosurgery",
        "year": 2018
    },
    "pQViBaVN": {
        "id": "pQViBaVN",
        "title": "Prognostic Significance of Resection Degree in Skull Base Chordoma: A Systematic Review and Meta-Analysis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Guohua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            }
        ],
        "venue": "World Neurosurgery",
        "year": 2017
    },
    "X0jonHCR": {
        "id": "X0jonHCR",
        "title": "Osteoid osteoma at the posterior element of lumbar spinal column in a young boy.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle of Renmin Rd, Changsha, Hunan 410011, China."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2016
    },
    "hDD3FX2M": {
        "id": "hDD3FX2M",
        "title": "Letter to the Editor concerning \u201cRisk factors of new symptomatic vertebral compression fractures in osteoporotic patients undergone percutaneous vertebroplasty\u201d by HL. Ren et al. (Eur Spine J; 2015;24(4):750\u2013758)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Zhihui Dai",
                "org": "Department of Orthopedics, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, China"
            },
            {
                "name": "Ding-Jun Hao",
                "org": "Department of Spine Surgery, Hong-Hui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, China"
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Ming Yang",
                "org": "Department of Spine Surgery, Hong-Hui Hospital, Xi\u2019an Jiaotong University College of Medicine, Xi\u2019an, China"
            }
        ],
        "venue": "European Spine Journal",
        "year": 2017
    },
    "Ku2u0hy8": {
        "id": "Ku2u0hy8",
        "title": "Bronchogenic cyst of the conus medullaris with spinal cord tethering: a case report and review of the literature.",
        "abstract": "Bronchogenic cysts (BCs) are congenital malformations that originate from remnants of the primitive foregut. Intraspinal BCs, especially those of the conus medullaris are rare with only one case reported until now. To date, a bronchogenic cyst with spinal cord tethering has not been previously reported. We reviewed the clinical course of a 44-year-old woman, who presented with low back pain and leg weakness as well as sphincter disturbance. Magnetic resonance imaging showed an intradural oval mass located at the conus medullaris. A tethered cord was also observed, as well as a dermal sinus tract. The mass was totally removed after an L3-L4 laminectomy without detethering during operation. Pathologic examination confirmed the diagnosis of bronchogenic cyst. By six months after treatment, the patient had experienced nearly complete recovery. The review of literature indicated that detethering was performed in most reported cases of neurenteric cysts with spinal cord tethering, and one of six patients was diagnosed with a postoperative recurrence. The co-existence of bronchogenic cyst and a tethered spinal cord would imply associated developmental errors in embryogenesis. It is worth noting that whether detethering is necessary after the cyst removal.",
        "keywords": [
            "Bronchogenic cyst",
            "conus medullaris",
            "intraspinal cyst",
            "neurenteric cyst",
            "tethered spinal cord"
        ],
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China."
            },
            {
                "name": "Jia-Rui Hu",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China."
            },
            {
                "name": "Yi-Jun Kang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China."
            },
            {
                "name": "Xiao-Ling She",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, China."
            }
        ],
        "venue": "International journal of clinical and experimental pathology",
        "year": 2015
    },
    "gDLYU6Qt": {
        "id": "gDLYU6Qt",
        "title": "Prognostic Biomarkers in Spinal Chordoma: A Systematic Review",
        "abstract": "To the Editor: We read with great interest the recent article by Tauziede-Espariat et al (1) on prognostic and therapeutic markers in chordomas. The authors performed a retrospective multicentric study of 287 chordomas from 111 patients and attempted to correlate clinical, histopathologic, and immunohistochemical parameters with chordoma prognosis. They found that the extent of resection, tumor grade, and proton therapy were independent prognostic factors of progression-free survival, whereas the extent of resection, tumor location, and grade were independent predictors of overall survival in the patients on multivariate analysis.We commend the authors for performing the largest study in the literature on chordomas; the disease is rare, and previously published studies investigating prognostic factors of chordoma were limited to a small number of patients. Currently, the Frankel score is widely used to evaluate neurological status (2). However, we noted that the authors did not find tumor location in the upper cervical spine (including the C1 and C2 vertebrae) or worse preoperative Frankel score to be an independent predictor, which contradicts results from previous studies (3\u20136).Recently, many biomarkers have been \u2026",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Guohua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"
            }
        ],
        "venue": "Journal of Neuropathology and Experimental Neurology",
        "year": 2016
    },
    "q4ZugDeE": {
        "id": "q4ZugDeE",
        "title": "Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.",
        "abstract": "Our data suggest a clinically relevant role of the immune microenvironment in spinal chordoma and identify the Immunoscore as promising prognostic marker.",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Wei Huang",
                "org": "Institute of Precision Medicine, Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Yi Jiang",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Xiao-Ling She",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China."
            }
        ],
        "venue": "Neurosurgery",
        "year": 2018
    },
    "dfhiHI28": {
        "id": "dfhiHI28",
        "title": "Clinical Impact of the Immune Microenvironment in Spinal Chordoma: Immunoscore as an Independent Favorable Prognostic Factor.",
        "abstract": "Our data suggest a clinically relevant role of the immune microenvironment in spinal chordoma and identify the Immunoscore as promising prognostic marker.",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Wei Huang",
                "org": "Institute of Precision Medicine, Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Yi Jiang",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China."
            },
            {
                "name": "Xiao-Ling She",
                "org": "Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, China."
            }
        ],
        "venue": "Neurosurgery",
        "year": 2018
    },
    "fRt01PYN": {
        "id": "fRt01PYN",
        "title": "Atlantoaxial rotatory dislocation due to spasmodic torticollis.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Ming-Xiang Zou",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Jing Li",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Guo-Hua Lv",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Xiao-Bin Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle Renmin Rd, Changsha, Hunan 410011, China."
            },
            {
                "name": "Bing Wang",
                "org": "Department of Spine Surgery, The Second Xiangya Hospital of Central South University, No 139, Middle Renmin Rd, Changsha, Hunan 410011, China."
            }
        ],
        "venue": "The spine journal : official journal of the North American Spine Society",
        "year": 2016
    },
    "8p1f0VIa": {
        "id": "8p1f0VIa",
        "title": "Effects of nanoparticle size on cellular uptake and liver MRI with polyvinylpyrrolidone-coated iron oxide nanoparticles.",
        "abstract": "The effect of nanoparticle size (30-120 nm) on magnetic resonance imaging (MRI) of hepatic lesions in vivo has been systematically examined using polyvinylpyrrolidone (PVP)-coated iron oxide nanoparticles (PVP-IOs). Such biocompatible PVP-IOs with different sizes were synthesized by a simple one-pot pyrolysis method. These PVP-IOs exhibited good crystallinity and high T(2) relaxivities, and the relaxivity increased with the size of the magnetic nanoparticles. It was found that cellular uptake changed with both size and surface physiochemical properties, and that PVP-IO-37 with a core size of 37 nm and hydrodynamic particle size of 100 nm exhibited higher cellular uptake rate and greater distribution than other PVP-IOs and Feridex. We systematically investigated the effect of nanoparticle size on MRI of normal liver and hepatic lesions in vivo. The physical and chemical properties of the nanoparticles influenced their pharmacokinetic behavior, which ultimately determined their ability to accumulate in the liver. The contrast enhancement of PVP-IOs within the liver was highly dependent on the overall size of the nanoparticles, and the 100 nm PVP-IO-37 nanoparticles exhibited the greatest enhancement. These results will have implications in designing engineered nanoparticles that are optimized as MR contrast agents or for use in therapeutics.",
        "keywords": [
            "iron oxide",
            "magnetic nanoparticles",
            "magnetic resonance imaging",
            "size dependent",
            "nanoparticles",
            "particle size"
        ],
        "authors": [
            {
                "name": "Jing Huang",
                "org": "James H. Clark Center(Stanford University,James H. Clark Center,Clark Center),Stanford,United States"
            },
            {
                "name": "Lihong Bu",
                "org": "James H. Clark Center(Stanford University,James H. Clark Center,Clark Center),Stanford,United States"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Kai Chen",
                "org": "James H. Clark Center(Stanford University,James H. Clark Center,Clark Center),Stanford,United States"
            },
            {
                "name": "Zhen Cheng",
                "org": "James H. Clark Center(Stanford University,James H. Clark Center,Clark Center),Stanford,United States"
            },
            {
                "name": "Xingguo Li",
                "org": "College of Chemistry and Molecular Engineering, Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "James H. Clark Center(Stanford University,James H. Clark Center,Clark Center),Stanford,United States"
            }
        ],
        "venue": "ACS nano",
        "year": 2010
    },
    "x7HsqC70": {
        "id": "x7HsqC70",
        "title": "Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.",
        "abstract": "We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.",
        "keywords": [
            "magnesium oxide",
            "magnetic resonance imaging",
            "particle size",
            "nanoparticles"
        ],
        "authors": [
            {
                "name": "Ruijun Xing",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Fan Zhang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Maria A. Aronova",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Guofeng Zhang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Ning Guo",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Xinglu Huang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Xiaolian Sun",
                "org": "Brown University(Brown University),Providence,United States"
            },
            {
                "name": "Gang Liu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "L. Henry Bryant",
                "org": "National Institutes of Health, Bethesda(National Institutes of Health,NIH),Bethesda,United States"
            },
            {
                "name": "Ashwinkumar A. Bhirde",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Amy Liang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Yanglong Hou",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Richard D. Leapman",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Shouheng Sun",
                "org": "Brown University(Brown University),Providence,United States"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Nanoscale",
        "year": 2011
    },
    "qEDQVZdY": {
        "id": "qEDQVZdY",
        "title": "Improving detection specificity of iron oxide nanoparticles (IONPs) using the SWIFT sequence with long T2 suppression",
        "abstract": "",
        "keywords": [
            "swift"
        ],
        "authors": [
            {
                "name": "luning wang",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            },
            {
                "name": "zipeng zhen",
                "org": ""
            },
            {
                "name": "hongming chen",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "qun zhao",
                "org": ""
            }
        ],
        "venue": "Magnetic Resonance Imaging",
        "year": 2014
    },
    "2DS7zBSL": {
        "id": "2DS7zBSL",
        "title": "Casein-Coated Fe5C2 Nanoparticles with Superior r2 Relaxivity for Liver-Specific Magnetic Resonance Imaging.",
        "abstract": "Iron oxide nanoparticles have been extensively used as T2 contrast agents for liver-specific magnetic resonance imaging (MRI). The applications, however, have been limited by their mediocre magnetism and r2 relaxivity. Recent studies show that Fe5C2 nanoparticles can be prepared by high temperature thermal decomposition. The resulting nanoparticles possess strong and air stable magnetism, suggesting their potential as a novel type of T2 contrast agent. To this end, we improve the synthetic and surface modification methods of Fe5C2 nanoparticles, and investigated the impact of size and coating on their performances for liver MRI. Specifically, we prepared 5, 14, and 22 nm Fe5C2 nanoparticles and engineered their surface by: 1) ligand addition with phospholipids, 2) ligand exchange with zwitterion-dopamine-sulfonate (ZDS), and 3) protein adsorption with casein. It was found that the size and surface coating have varied levels of impact on the particlesu0027 hydrodynamic size, viability, uptake by macrophages, and r2 relaxivity. Interestingly, while phospholipid- and ZDS-coated Fe5C2 nanoparticles showed comparable r2, the casein coating led to an r2 enhancement by more than 2 fold. In particular, casein coated 22 nm Fe5C2 nanoparticle show a striking r2 of 973 mM-1s-1, which is one of the highest among all of the T2 contrast agents reported to date. Small animal studies confirmed the advantage of Fe5C2 nanoparticles over iron oxide nanoparticles in inducing hypointensities on T2-weighted MR images, and the particles caused little toxicity to the host. The improvements are important for transforming Fe5C2 nanoparticles into a new class of MRI contrast agents. The observations also shed light on protein-based surface modification as a means to modulate contrast ability of magnetic nanoparticles.",
        "keywords": "",
        "authors": [
            {
                "name": "Taku Cowger",
                "org": ""
            },
            {
                "name": "Wei Tang",
                "org": ""
            },
            {
                "name": "Zipeng Zhen",
                "org": ""
            },
            {
                "name": "Kai Hu",
                "org": ""
            },
            {
                "name": "David E. Rink",
                "org": ""
            },
            {
                "name": "Trever Todd",
                "org": ""
            },
            {
                "name": "Geoffrey D. Wang",
                "org": ""
            },
            {
                "name": "Weizhong Zhang",
                "org": ""
            },
            {
                "name": "Hongmin Chen",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "Theranostics",
        "year": 2015
    },
    "LY5ZLixP": {
        "id": "LY5ZLixP",
        "title": "PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles.",
        "abstract": "The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for PET and MRI scans of tumor integrin alphavbeta3 expression.Polyaspartic acid (PASP)-coated IO (PASP-IO) nanoparticles were synthesized using a coprecipitation method, and particle size and magnetic properties were measured. A phantom study was used to assess the efficacy of PASP-IO as a T2-weighted MRI contrast agent. PASP-IO nanoparticles with surface amino groups were coupled to cyclic arginine-glycine-aspartic (RGD) peptides for integrin alphavbeta3 targeting and macrocyclic 1,4,7,10-tetraazacyclododecane-N,N',N'',N''',-tetraacetic acid (DOTA) chelators for PET after labeling with 64Cu. IO nanoparticle conjugates were further tested in vitro and in vivo to determine receptor targeting efficacy and feasibility for dual PET/MRI.PASP-IO nanoparticles made by single-step reaction have a core size of 5 nm with a hydrodynamic diameter of 45 +/- 10 nm. The saturation magnetization of PASP-IO nanoparticles is about 117 emu/g of iron, and the measured r2 and r2* are 105.5 and 165.5 (s.mM)(-1), respectively. A displacement competitive binding assay indicates that DOTA-IO-RGD conjugates bound specifically to integrin alphavbeta3 in vitro. Both small-animal PET and T2-weighted MRI show integrin-specific delivery of conjugated RGD-PASP-IO nanoparticles and prominent reticuloendothelial system uptake.We have successfully developed an IO-based nanoprobe for simultaneous dual PET and MRI of tumor integrin expression. The success of this bifunctional imaging approach may allow for earlier tumor detection with a high degree of accuracy and provide further insight into the molecular mechanisms of cancer.",
        "keywords": [
            "mri",
            "integrin avb3",
            "pet",
            "iron oxide nanoparticle",
            "rgd peptide",
            "bi- functional probe",
            "magnetic properties",
            "particle size",
            "molecular mechanics",
            "iron"
        ],
        "authors": [
            {
                "name": "Ha-Young Lee",
                "org": ""
            },
            {
                "name": "Zibo Li",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Andrew R. Hsu",
                "org": ""
            },
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Journal of nuclear medicine : official publication, Society of Nuclear Medicine",
        "year": 2008
    },
    "ZAbPKntA": {
        "id": "ZAbPKntA",
        "title": "Red Blood Cell\u2010Facilitated Photodynamic Therapy for Cancer Treatment",
        "abstract": "Photodynamic therapy (PDT) is a promising treatment modality for cancer management. So far, most PDT studies have focused on delivery of photo\u00adsensitizers to tumors. O2, another essential component of PDT, is not artificially delivered but taken from the biological milieu. However, cancer cells demand a large amount of O2 to sustain their growth and that often leads to low O2 levels in tumors. The PDT process may further potentiate the oxygen deficiency, and in turn, adversely affect the PDT efficiency. In the present study, a new technology called red blood cell (RBC)-facilitated PDT, or RBC-PDT, is introduced that can potentially solve the issue. As the name tells, RBC-PDT harnesses erythrocytes, an O2 transporter, as a carrier for photosensitizers. Because photosensitizers are adjacent to a carry-on O2 source, RBC-PDT can efficiently produce 1O2 even under low oxygen conditions. The treatment also benefits from the long circulation of RBCs, which ensures a high intraluminal concentration of photosensitizers during PDT and hence maximizes damage to tumor blood vessels. When tested in U87MG subcutaneous tumor models, RBC-PDT shows impressive tumor suppression (76.7%) that is attributable to the codelivery of O2 and photosensitizers. Overall, RBC-PDT is expected to find wide applications in modern oncology.",
        "keywords": "",
        "authors": [
            {
                "name": "Wei Tang",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Zipeng Zhen",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Mengzhe Wang",
                "org": "Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA"
            },
            {
                "name": "Hui Wang",
                "org": "Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA"
            },
            {
                "name": "Yen-Jun Chuang",
                "org": "College of Engineering University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Weizhong Zhang",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Geoffrey D Wang",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Trever Todd",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Taku Cowger",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Hongmin Chen",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            },
            {
                "name": "Lin Liu",
                "org": "Department of Radiology China\u2010Japan Union Hospital Jilin University Changchun Jilin 130033 China"
            },
            {
                "name": "Zibo Li",
                "org": "Department of Radiology and Biomedical Research Imaging Center University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA"
            },
            {
                "name": "Jin Xie",
                "org": "Department of Chemistry University of Georgia Athens GA 30602 USA"
            }
        ],
        "venue": "Advanced Functional Materials",
        "year": 2016
    },
    "QHCQm1wt": {
        "id": "QHCQm1wt",
        "title": "R\u00fccktitelbild: Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)\u2010Functionalized, Self\u2010Assembled Nanoconjugate (Angew. Chem. 2/2012)",
        "abstract": "",
        "keywords": [
            "sirna"
        ],
        "authors": [
            {
                "name": "gang liu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "ki young choi",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "ashwinkumar bhirde",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "magdalena swierczewska",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "juan yin",
                "org": "national cancer institute"
            },
            {
                "name": "s w lee",
                "org": "seoul national university"
            },
            {
                "name": "jae hyung park",
                "org": "sungkyunkwan university"
            },
            {
                "name": "jong in hong",
                "org": "seoul national university"
            },
            {
                "name": "jin xie",
                "org": "university of georgia"
            },
            {
                "name": "gang niu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "dale o kiesewetter",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "xiaoyuan chen",
                "org": "national institute of biomedical imaging and bioengineering"
            }
        ],
        "venue": "Angewandte Chemie",
        "year": 2012
    },
    "E6uHkvjs": {
        "id": "E6uHkvjs",
        "title": "Human serum albumin coated iron oxide nanoparticles for efficient cell labeling.",
        "abstract": "A novel dopamine-plus-HSA (human serum albumin) approach was developed to functionalize iron oxide nanoparticles (IONPs), yielding nanoconjugates that are highly efficient in labeling various types of cell lines, which was demonstrated by in vivo MR imaging on xenograft and focal cerebral ischemia models.",
        "keywords": [
            "human serum albumin",
            "cell line",
            "cerebrum",
            "endocytosis",
            "serum albumin",
            "magnetic resonance imaging",
            "nanoparticles"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Jinhua Wang",
                "org": ""
            },
            {
                "name": "Gang Niu",
                "org": ""
            },
            {
                "name": "Jing Huang",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Xingguo Li",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Chemical communications (Cambridge, England)",
        "year": 2010
    },
    "GUe8LsfQ": {
        "id": "GUe8LsfQ",
        "title": "Peptides and peptide hormones for molecular imaging and disease diagnosis.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Seulki Lee",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Chemical reviews",
        "year": 2010
    },
    "lz8Toeni": {
        "id": "lz8Toeni",
        "title": "RGD-human serum albumin conjugates as efficient tumor targeting probes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "kai chen",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "NGWjwK4m": {
        "id": "NGWjwK4m",
        "title": "Detection of DNA labeled with magnetic nanoparticles using MgO-based magnetic tunnel junction sensors",
        "abstract": "",
        "keywords": [
            "biomedical engineering",
            "sensor array",
            "signal to noise ratio",
            "magnetic tunnel junction"
        ],
        "authors": [
            {
                "name": "weifeng shen",
                "org": "brown university"
            },
            {
                "name": "b d schrag",
                "org": ""
            },
            {
                "name": "matthew carter",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": "brown university"
            },
            {
                "name": "chenjie xu",
                "org": "brown university"
            },
            {
                "name": "shouheng sun",
                "org": "brown university"
            },
            {
                "name": "gang xiao",
                "org": "brown university"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2008
    },
    "pJIPDtGs": {
        "id": "pJIPDtGs",
        "title": "Dual-functional, receptor-targeted fluorogenic probe for in vivo imaging of extracellular protease expressions.",
        "abstract": "Herein, we report a new type of in vivo fluorogenic probe that enables simultaneous and active targeting of overexpressed receptors, \u03b1(V)\u03b2(3) integrins, and extracellular proteases, matrix metalloproteinases (MMPs), in the tumor regions. This c(RGDyK)-conjugated MMP fluorogenic probe efficiently targets the tumor regions with high retention time while maintaining receptor binding affinity and substrate activity. The probe minimizes nonspecific accumulation, thus demonstrating improved tumor-to-background signal ratio (T/N) in both \u03b1(V)\u03b2(3) integrin- and MMP-overexpressing U87MG tumor-bearing mouse model. This strategy can be easily tuned for a wide array of applications targeting various receptors and extracellular proteases in vivo.",
        "keywords": [
            "stereoisomerism",
            "matrix metalloproteinases",
            "molecular imaging",
            "molecular structure"
        ],
        "authors": [
            {
                "name": "Lei Zhu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Magdalena Swierczewska",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Fan Zhang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Xin Lin",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Xuexun Fang",
                "org": "Jilin University(Jilin University),Changchun,China"
            },
            {
                "name": "Gang Niu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Seulki Lee",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Bioconjugate chemistry",
        "year": 2011
    },
    "p3NqmPFI": {
        "id": "p3NqmPFI",
        "title": "Production, Modification and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria.",
        "abstract": "Magnetotactic bacteria (MTB) were first discovered by Richard P. Blakemore in 1975, and this led to the discovery of a wide collection of microorganisms with similar features i.e., the ability to internalize Fe and convert it into magnetic nanoparticles, in the form of either magnetite (Fe(3)O(4)) or greigite (Fe(3)S(4)). Studies showed that these particles are highly crystalline, monodisperse, bioengineerable and have high magnetism that is comparable to those made by advanced synthetic methods, making them candidate materials for a broad range of bio-applications. In this review article, the history of the discovery of MTB and subsequent efforts to elucidate the mechanisms behind the magnetosome formation are briefly covered. The focus is on how to utilize the knowledge gained from fundamental studies to fabricate functional MTB nanoparticles (MTB-NPs) that are capable of tackling real biomedical problems.",
        "keywords": [
            "magnetosome",
            "magnetic resonance imaging mri",
            "bio-application",
            "magnetotactic bacteria mtb",
            "bioinformatics",
            "biomedical research",
            "magnetic resonance image"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": "Stanford University School of Medicine Department of Radiology, Bio-X Program Stanford CA 94305-5484 USA"
            },
            {
                "name": "Kai Chen",
                "org": "Stanford University School of Medicine Department of Radiology, Bio-X Program Stanford CA 94305-5484 USA"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "Stanford University School of Medicine Department of Radiology, Bio-X Program Stanford CA 94305-5484 USA"
            }
        ],
        "venue": "Nano research",
        "year": 2009
    },
    "xWNCAtR7": {
        "id": "xWNCAtR7",
        "title": "PET/MRI dual modality tumor imaging using RGD conjugated radiolabeled iron oxide nanoparticles",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zibo li",
                "org": ""
            },
            {
                "name": "hayoung lee",
                "org": ""
            },
            {
                "name": "kai chen",
                "org": ""
            },
            {
                "name": "andrew r hsu",
                "org": ""
            },
            {
                "name": "chenjie xu",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "shouheng sun",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "VODp0jo6": {
        "id": "VODp0jo6",
        "title": "HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy.",
        "abstract": "An ongoing effort in the field of nanomedicine is to develop nanoplatforms with both imaging and therapeutic functions, the \"nanotheranostics\". We have previously developed a human serum albumin (HSA) coated iron oxide nanoparticle (HINP) formula and used multiple imaging modalities to validate its tumor targeting attributes. In the current study, we sought to impart doxorubicin (Dox) onto the HINPs and to assess the potential of the conjugates as theranostic agents. In a typical preparation, we found that about 0.5 mg of Dox and 1 mg of iron oxide nanoparticles (IONPs, Fe content) could be loaded into 10 mg of HSA matrices. The resulting D-HINPs (Dox loaded HINPs) have a hydrodynamic size of 50 nm and are able to release Dox in a sustained fashion. More impressively, the HINPs can assist the translocation of Dox across the cell membrane and even its accumulation in the nucleus. In vivo, D-HINPs retained a tumor targeting capability of HINPs, as manifested by both in vivo MRI and ex vivo immunostaining results. In a follow-up therapeutic study on a 4T1 murine breast cancer xenograft model, D-HINPs showed a striking tumor suppression effect that was comparable to that of Doxil and greatly outperformed free Dox. Such a strategy can be readily extended to load other types of small molecules, making HINP a promising theranostic nanoplatform.",
        "keywords": [
            "drug delivery",
            "doxorubicin",
            "magnetic resonance imaging",
            "breast cancer",
            "theranostic nanomedicine",
            "iron oxide nanoparticle",
            "half life",
            "serum albumin"
        ],
        "authors": [
            {
                "name": "Qimeng Quan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "HaoKao Gao",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Min Yang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Fan Zhang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Gang Liu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Xin Lin",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Andrew Wang",
                "org": "Ocean Nanotech(Ocean Nano Tech,Ocean NanoTech,Ocean Nanotech),,United States"
            },
            {
                "name": "Henry S. Eden",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Seulki Lee",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Guixiang Zhang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Molecular pharmaceutics",
        "year": 2011
    },
    "K3W8h7Ho": {
        "id": "K3W8h7Ho",
        "title": "N-Alkyl-PEI-functionalized iron oxide nanoclusters for efficient siRNA delivery.",
        "abstract": "Small-interfering RNA (siRNA) is an emerging class of therapeutics, which works by regulating the expression of a specific gene involved in disease progression. Despite the promises, effective transport of siRNA with minimal side effects remains a challenge. In this study, a nonviral nanoparticle gene carrier is developed and its efficiency for siRNA delivery and transfection is validated at both in vitro and in vivo levels. Such a nanocarrier, abbreviated as Alkyl-PEI2k-IO, was constructed with a core of iron oxide nanoparticles (IOs) and a shell of alkylated polyethyleneimine of 2000 Da [corrected] molecualr weight (Alkyl-PEI2k). It is found to be able to bind with siRNA, resulting in well-dispersed nanoparticles with a controlled clustering structure and narrow size distribution. Electrophoresis studies show that the Alkyl-PEI2k-IOs could retard siRNA completely at N:P ratios (i.e., PEI nitrogen to nucleic acid phosphate) above 10, protect siRNA from enzymatic degradation in serum, and release complexed siRNA efficiently in the presence of polyanionic heparin. The knockdown efficiency of the siRNA-loaded nanocarriers is assessed with 4T1 cells stably expressing luciferase (fluc-4T1) and further, with a fluc-4T1 xenograft model. Significant down-regulation of luciferase is observed, and unlike high-molecular-weight analogues, the Alkyl-PEI2k-coated IOs show good biocompatibility. In conclusion, Alkyl-PEI2k-IOs demonstrate highly efficient delivery of siRNA and an innocuous toxic profile, making it a potential carrier for gene therapy.",
        "keywords": [
            "biomaterials",
            "polyethyleneimine",
            "small-interfering rna",
            "superparamagnetic nanoparticles",
            "small interfering rna"
        ],
        "authors": [
            {
                "name": "Gang Liu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Fan Zhang",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Zhiyong Wang",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Kui Luo",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Lei Zhu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Qimeng Quan",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Gang Niu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Seulki Lee",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Hua Ai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Small (Weinheim an der Bergstrasse, Germany)",
        "year": 2011
    },
    "wzDIfsTH": {
        "id": "wzDIfsTH",
        "title": "Au-Fe3O4 dumbbell nanoparticles as dual-functional probes.",
        "abstract": "",
        "keywords": [
            "magnetic resonance imaging",
            "particle size",
            "antibodies",
            "nanoparticles",
            "magnetic properties",
            "magnetics"
        ],
        "authors": [
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Don Ho",
                "org": ""
            },
            {
                "name": "Chao Wang",
                "org": ""
            },
            {
                "name": "Nathan Kohler",
                "org": ""
            },
            {
                "name": "Edward\u2005G. Walsh",
                "org": ""
            },
            {
                "name": "Jeffrey\u2005R. Morgan",
                "org": ""
            },
            {
                "name": "Y.\u2005Eugene Chin",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Angewandte Chemie (International ed. in English)",
        "year": 2008
    },
    "eVblN65Y": {
        "id": "eVblN65Y",
        "title": "Diffusion-Weighted Magnetic Resonance Imaging for Therapy Response Monitoring and Early Treatment Prediction of Photothermal Therapy.",
        "abstract": "Photothermal therapy (PTT) as a relatively new cancer treatment method has attracted worldwide attention. Previous research on PTT has focused on its therapy efficiency and selectivity. The early prognosis of PTT, which is pivotal for the assessment of the treatment and the therapy stratification, however, has been rarely studied. In the present study, we investigated diffusion-weighted magnetic resonance imaging (DW-MRI) as a tool for therapy monitoring and early prognosis of PTT. To this end, we injected PEGylated graphene oxide (GO-PEG) or iron oxide deposited graphene oxide (GO-IONP-PEG) to 4T1 tumor models and irradiated the tumors at different drug-light intervals to induce PTT. For GO-IONP-PEG injected animals, we also included therapy arms where an external magnetic field was applied to the tumors to improve the delivery of the nanoparticle transducers. DW-MRI was performed at different time points after PTT and the tumor apparent diffusion coefficients (ADCs) were analyzed and compared. Our studi...",
        "keywords": "",
        "authors": [
            {
                "name": "Guifeng Fu",
                "org": ""
            },
            {
                "name": "Lei Zhu",
                "org": ""
            },
            {
                "name": "Kai Yang",
                "org": ""
            },
            {
                "name": "Rongqiang Zhuang",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Fan Zhang",
                "org": ""
            }
        ],
        "venue": "ACS Applied Materials & Interfaces",
        "year": 2016
    },
    "3XD7kyOf": {
        "id": "3XD7kyOf",
        "title": "Activatable molecular probes for cancer imaging.",
        "abstract": "The development of highly sensitive and specific molecular probes for cancer imaging still remains a daunting challenge. Recently, interdisciplinary research at the interface of imaging sciences and bionanoconjugation chemistry has generated novel activatable imaging probes that can provide high-resolution imaging with ultra-low background signals. Activatable imaging probes are designed to amplify output imaging signals in response to specific biomolecular recognition or environmental changes in real time. This review introduces and highlights the unique design strategies and applications of various activatable imaging probes in cancer imaging.",
        "keywords": [],
        "authors": [
            {
                "name": "Seulki Lee",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Current topics in medicinal chemistry",
        "year": 2010
    },
    "aCIIs7WB": {
        "id": "aCIIs7WB",
        "title": "Linking Hydrophilic Macromolecules to Monodisperse Magnetite (Fe<sub>3</sub>O<sub>4</sub>) Nanoparticles via Trichloro-<i>s</i>-triazine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Zhichuan Xu",
                "org": ""
            },
            {
                "name": "Yanglong Hou",
                "org": ""
            },
            {
                "name": "Kaylie L. Young",
                "org": ""
            },
            {
                "name": "S. X. Wang",
                "org": ""
            },
            {
                "name": "N. Pourmand",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Chemistry of Materials",
        "year": 2006
    },
    "EYwr2atp": {
        "id": "EYwr2atp",
        "title": "Back Cover: Sticky Nanoparticles: A Platform for siRNA Delivery by a Bis(zinc(II) dipicolylamine)\u2010Functionalized, Self\u2010Assembled Nanoconjugate (Angew. Chem. Int. Ed. 2/2012)",
        "abstract": "",
        "keywords": [
            "sirna",
            "nanoparticles"
        ],
        "authors": [
            {
                "name": "gang liu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "ki young choi",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "ashwinkumar bhirde",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "magdalena swierczewska",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "juan yin",
                "org": "national cancer institute"
            },
            {
                "name": "s w lee",
                "org": "seoul national university"
            },
            {
                "name": "jae hyung park",
                "org": "sungkyunkwan university"
            },
            {
                "name": "jong in hong",
                "org": "seoul national university"
            },
            {
                "name": "jin xie",
                "org": "university of georgia"
            },
            {
                "name": "gang niu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "dale o kiesewetter",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "xiaoyuan chen",
                "org": "national institute of biomedical imaging and bioengineering"
            }
        ],
        "venue": "Angewandte Chemie",
        "year": 2012
    },
    "7fgrpygQ": {
        "id": "7fgrpygQ",
        "title": "Ferritin enhances SPIO tracking of C6 rat glioma cells by MRI.",
        "abstract": "To investigate the effect of ferritin protein overexpression on superparamagnetic iron oxide (SPIO) particle labeling of C6 rat glioma cells, and track the labeled cells in vivo using magnetic resonance imaging (MRI).A plasmid of H-chain of murine ferritin gene was constructed and transfected into C6 cells. The parental and the transfected C6 cells labeled with SPIO were bilaterally inoculated subcutaneously into nude mice. The mice were imaged by multiple T2-weighted MR scans after C6 cell inoculation. The mice were killed 2 weeks later, and the concentration of iron in the tumor tissue was measured by inductively coupled plasma.The iron concentration in xenografts derived from SPIO-labeled C6 cells that were transfected with ferritin plasmid was significantly higher than that in xenografts from parental C6 cells that were labeled with SPIO but not transfected (p = 0.034, N = 5). Ferritin-transfected C6 cells showed an improved T(2) contrast in vivo compared with parental cells labeled with SPIO but not transfected.Coordinating ferritin with SPIO can lead to a longer MRI cellular tracking period.",
        "keywords": [
            "superparamagnetic iron oxide spio particle",
            "mri",
            "ferritin reporter",
            "cell tracking",
            "inductive coupled plasma",
            "magnetic resonance image",
            "iron"
        ],
        "authors": [
            {
                "name": "Jiandong Wang",
                "org": "Radiology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Jin Xie",
                "org": "Laboratory for Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Drive, Suite 1C14 MSC 2281, Bethesda, MD 20892-2281, USA"
            },
            {
                "name": "Xiaojun Zhou",
                "org": "Pathology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Zhen Cheng",
                "org": "Department of Radiology, Molecular Imaging Program, 1201 Welch Road, Lucas Center, P020A, Stanford, CA 94305-5484, USA"
            },
            {
                "name": "Ning Gu",
                "org": "Radiology Department, Southeast University, Nanjing, 210009 China"
            },
            {
                "name": "Gaojun Teng",
                "org": "Chemistry Department, Southeast University, Nanjing, 210009 China"
            },
            {
                "name": "Qiujue Hu",
                "org": "Radiology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Feipeng Zhu",
                "org": "Radiology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Shuanghui Chang",
                "org": "Radiology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Fan Zhang",
                "org": "Radiology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Guangming Lu",
                "org": "Radiology Department, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002 China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "Laboratory for Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 31 Center Drive, Suite 1C14 MSC 2281, Bethesda, MD 20892-2281, USA"
            }
        ],
        "venue": "Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging",
        "year": 2011
    },
    "yoBFUU1I": {
        "id": "yoBFUU1I",
        "title": "Abstract 4437: HSA coated iron oxide nanoparticle as a drug delivery vehicle for cancer therapy",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoyuan chen",
                "org": ""
            },
            {
                "name": "qimeng quan",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2014
    },
    "70uExKAg": {
        "id": "70uExKAg",
        "title": "pH Controlled Release of Chromone from Chromone-Fe<sub>3</sub>O<sub>4</sub>Nanoparticles",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Baodui Wang",
                "org": ""
            },
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Zhengyin Yang",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Journal of The American Chemical Society",
        "year": 2008
    },
    "aOKSwEep": {
        "id": "aOKSwEep",
        "title": "In vivo MRI tracking of cell invasion and migration in a rat glioma model.",
        "abstract": "Malignant brain tumors are characterized by extensive infiltration into the normal brain tissue. Tumor migration is a complicated process which results from the interplay of a number of mechanisms, and the extent to which anatomic structure determined the migration pattern has not been extensively addressed. In the present study, we labeled C6 glioma cells with iron oxide nanoparticles and monitored the fate of the cells in vivo with magnetic resonance imaging (MRI).C6 glioma cells were labeled with ferumoxide-poly-L-lysine complexes and their migration in the brains of rats tracked by T2-weighted MRI. The same amount of iron-laden cells were implanted into the caudate nucleus (CN) and at the vicinity of anterior commissure (AC), respectively, and MRI was performed during the course of 20-day monitoring period to track tumor growth and migration.A clear tendency of tumor migration along the white matter fiber tracts was observed in the AC group, which is consistent with the previous reports; by contrast, tumor expanded to but remained confined within the boundary of right hemisphere in the CN group.We successfully demonstrated the ability of MRI to investigate the impact of anatomical structure on the glioma migration pathway in vivo.",
        "keywords": [
            "superparamagnetic iron oxide (spio) nanoparticles",
            "cell trafficking",
            "glioma",
            "tumor invasion and migration",
            "magnetic resonance imaging (mri)"
        ],
        "authors": [
            {
                "name": "Fan Zhang",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Gang Liu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Yulong He",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Guangming L\u00fc",
                "org": "Nanjing University, School of Medicine(Nanjing University School of Medicine,Nanjing University Medical School,Medical School of Nanjing University),Nanjing,China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging",
        "year": 2011
    },
    "oBP7LtKB": {
        "id": "oBP7LtKB",
        "title": "Monodisperse Magnetic Nanoparticles: Chemical Synthesis and Surface Modification",
        "abstract": "",
        "keywords": [
            "magnetic nanoparticles"
        ],
        "authors": [
            {
                "name": "jin xie",
                "org": "brown university"
            },
            {
                "name": "shouheng sun",
                "org": "brown university"
            }
        ],
        "venue": "",
        "year": 2009
    },
    "0qYenQGK": {
        "id": "0qYenQGK",
        "title": "Corrigendum: N\u2010Alkyl\u2010PEI\u2010Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "gang liu",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "fan zhang",
                "org": ""
            },
            {
                "name": "zhiyong wang",
                "org": ""
            },
            {
                "name": "kui luo",
                "org": ""
            },
            {
                "name": "lei zhu",
                "org": ""
            },
            {
                "name": "qimeng quan",
                "org": ""
            },
            {
                "name": "gang niu",
                "org": ""
            },
            {
                "name": "seulki lee",
                "org": ""
            },
            {
                "name": "hua ai",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "Small",
        "year": 2011
    },
    "lEGQR41q": {
        "id": "lEGQR41q",
        "title": "Synthesis of Co/MFe2O4 (M=Fe, Mn) core/shell nanocomposite particles",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Sheng Peng",
                "org": "Department of Chemistry, Brown University, Providence, RI 02912, USA"
            },
            {
                "name": "Jin Xie",
                "org": "Department of Chemistry, Brown University, Providence, RI 02912, USA"
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Journal of Solid State Chemistry",
        "year": 2008
    },
    "V0wL1dEQ": {
        "id": "V0wL1dEQ",
        "title": "Composite magnetic nanoparticles: Synthesis and cancer-related applications",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ping cai",
                "org": ""
            },
            {
                "name": "hongmin chen",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            }
        ],
        "venue": "Chinese Physics B",
        "year": 2014
    },
    "aUXm5Izz": {
        "id": "aUXm5Izz",
        "title": "Assessment and comparison of magnetic nanoparticles as MRI contrast agents in a rodent model of human hepatocellular carcinoma: Magnetic nanoparticles for HCC imaging",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "kai chen",
                "org": ""
            },
            {
                "name": "jing huang",
                "org": ""
            },
            {
                "name": "zoraida p aguilar",
                "org": ""
            },
            {
                "name": "andrew wang",
                "org": ""
            },
            {
                "name": "kin wai sun",
                "org": ""
            },
            {
                "name": "meisze chua",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            },
            {
                "name": "baozhong shen",
                "org": ""
            },
            {
                "name": "henry s eden",
                "org": ""
            },
            {
                "name": "samuel so",
                "org": ""
            },
            {
                "name": "zhen cheng",
                "org": ""
            },
            {
                "name": "lihong bu",
                "org": ""
            }
        ],
        "venue": "Contrast Media & Molecular Imaging",
        "year": 2012
    },
    "q1IereWU": {
        "id": "q1IereWU",
        "title": "Synthesis of Nanomaterials as a Platform for Molecular Imaging",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinhao gao",
                "org": "stanford university"
            },
            {
                "name": "jin xie",
                "org": "stanford university"
            },
            {
                "name": "bing xu",
                "org": "brandeis university"
            },
            {
                "name": "xiaoyuan chen",
                "org": "stanford university"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "fr1yJiWi": {
        "id": "fr1yJiWi",
        "title": "Surface-engineered magnetic nanoparticle platforms for cancer imaging and therapy.",
        "abstract": "Enormous efforts have been made toward the translation of nanotechnology into medical practice, including cancer management. Generally the applications have fallen into two categories: diagnosis and therapy. Because the targets are often the same, the development of separate approaches can miss opportunities to improve efficiency and effectiveness. The unique physical properties of nanomaterials enable them to serve as the basis for superior imaging probes to locate and report cancerous lesions and as vehicles to deliver therapeutics preferentially to those lesions. These technologies for probes and vehicles have converged in the current efforts to develop nanotheranostics, nanoplatforms with both imaging and therapeutic functionalities. These new multimodal platforms are highly versatile and valuable components of the emerging trend toward personalized medicine, which emphasizes tailoring treatments to the biology of individual patients to optimize outcomes. The close coupling of imaging and treatment within a theranostic agent and the data about the evolving course of an illness that these agents provide can facilitate informed decisions about modifications to treatment. Magnetic nanoparticles, especially superparamagnetic iron oxide nanoparticles (IONPs), have long been studied as contrast agents for magnetic resonance imaging (MRI). Owing to recent progress in synthesis and surface modification, many new avenues have opened for this class of biomaterials. Such nanoparticles are not merely tiny magnetic crystals, but potential platforms with large surface-to-volume ratios. By taking advantage of the well-developed surface chemistry of these materials, researchers can load a wide range of functionalities, such as targeting, imaging and therapeutic features, onto their surfaces. This versatility makes magnetic nanoparticles excellent scaffolds for the construction of theranostic agents, and many efforts have been launched toward this goal. In this Account, we introduce the surface engineering techniques that we and others have developed, with an emphasis on how these techniques affect the role of nanoparticles as imaging or therapeutic agents. We and others have developed a set of chemical methods to prepare magnetic nanoparticles that possess accurate sizes, shapes, compositions, magnetizations, relaxivities, and surface charges. These features, in turn, can be harnessed to adjust the toxicity and stability of the nanoparticles and, further, to load functionalities, via various mechanisms, onto the nanoparticle surfaces.",
        "keywords": [
            "nanoparticles",
            "molecular imaging"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Gang Liu",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Henry S. Eden",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Hua Ai",
                "org": "Sichuan University(Sichuan University),Chengdu,China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Accounts of chemical research",
        "year": 2011
    },
    "OBwaSsmg": {
        "id": "OBwaSsmg",
        "title": "Peptide-based probes for targeted molecular imaging.",
        "abstract": "Targeted molecular imaging techniques have become indispensable tools in modern diagnostics because they provide accurate and specific diagnosis of disease information. Conventional nonspecific contrast agents suffer from low targeting efficiency; thus, the use of molecularly targeted imaging probes is needed depending on different imaging modalities. Although recent technologies have yielded various strategies for designing smart probes, utilization of peptide-based probes has been most successful. Phage display technology and combinatorial peptide chemistry have profoundly impacted the pool of available targeting peptides for the efficient and specific delivery of imaging labels. To date, selected peptides that target a variety of disease-related receptors and biomarkers are in place. These targeting peptides can be coupled with the appropriate imaging moieties or nanoplatforms on demand with the help of sophisticated bioconjugation or radiolabeling techniques. This review article examines the current trends in peptide-based imaging probes developed for in vivo applications. We discuss the advantage of and challenges in developing peptide-based probes and summarize current systems with respect to their unique design strategies and applications.",
        "keywords": [
            "molecular imaging"
        ],
        "authors": [
            {
                "name": "Seulki Lee",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Biochemistry",
        "year": 2010
    },
    "u2FvKGIE": {
        "id": "u2FvKGIE",
        "title": "Conjugating Methotrexate to magnetite (Fe3O4) nanoparticlesviatrichloro-s-triazine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kaylie l young",
                "org": "brown university"
            },
            {
                "name": "chenjie xu",
                "org": "brown university"
            },
            {
                "name": "jin xie",
                "org": "brown university"
            },
            {
                "name": "shouheng sun",
                "org": "brown university"
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2009
    },
    "PGTj0CB0": {
        "id": "PGTj0CB0",
        "title": "HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging.",
        "abstract": "We report in this Communication a facile, two-step surface modification strategy to achieve manganese oxide nanoparticles with prominent MRI T1 contrast. In a U87MG glioblastoma xenograft model, we confirmed that the particles can accumulate efficiently in tumor area to induce effective T1 signal alteration.",
        "keywords": [],
        "authors": [
            {
                "name": "Jing Huang",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Lihong Bu",
                "org": ""
            },
            {
                "name": "Seulki Lee",
                "org": ""
            },
            {
                "name": "Zhen Cheng",
                "org": ""
            },
            {
                "name": "Xingguo Li",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Chemical communications (Cambridge, England)",
        "year": 2010
    },
    "ChEU91Qf": {
        "id": "ChEU91Qf",
        "title": "Synthesis and stabilization of monodisperse Fe nanoparticles.",
        "abstract": "Monodisperse Fe nanoparticles are synthesized via a simple one-pot thermal decomposition of Fe(CO)5 in the presence of oleylamine. Controlled oxidation of the iron surface leads to crystalline Fe3O4 shell and results in dramatic increase of chemical and dispersion stability of the nanoparticles. Surface ligand exchange is readily applied to transfer the core/shell nanoparticles from hydrophobic to hydrophilic, and a stable aqueous nanoparticle dispersion in PBS is formed. The functionalized nanoparticles are suitable for biomolecule attachment and biomedical applications.",
        "keywords": [],
        "authors": [
            {
                "name": "Sheng Peng",
                "org": ""
            },
            {
                "name": "Chao Wang",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Journal of the American Chemical Society",
        "year": 2006
    },
    "hfsOWlns": {
        "id": "hfsOWlns",
        "title": "Protein-based tumor molecular imaging probes.",
        "abstract": "Molecular imaging is an emerging discipline which plays critical roles in diagnosis and therapeutics. It visualizes and quantifies markers that are aberrantly expressed during the disease origin and development. Protein molecules remain to be one major class of imaging probes, and the option has been widely diversified due to the recent advances in protein engineering techniques. Antibodies are part of the immunosystem which interact with target antigens with high specificity and affinity. They have long been investigated as imaging probes and were coupled with imaging motifs such as radioisotopes for that purpose. However, the relatively large size of antibodies leads to a half-life that is too long for common imaging purposes. Besides, it may also cause a poor tissue penetration rate and thus compromise some medical applications. It is under this context that various engineered protein probes, essentially antibody fragments, protein scaffolds, and natural ligands have been developed. Compared to intact antibodies, they possess more compact size, shorter clearance time, and better tumor penetration. One major challenge of using protein probes in molecular imaging is the affected biological activity resulted from random labeling. Site-specific modification, however, allows conjugation happening in a stoichiometric fashion with little perturbation of protein activity. The present review will discuss protein-based probes with focus on their application and related site-specific conjugation strategies in tumor imaging.",
        "keywords": [
            "tumor targetingantibody \ufffd human epidermal growth factor receptor her \ufffd vascular endothelial growth factor vegf"
        ],
        "authors": [
            {
                "name": "Xin Lin",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bldg. 31, Room 1C22, Bethesda, MD 20892, USA"
            },
            {
                "name": "Jin Xie",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bldg. 31, Room 1C22, Bethesda, MD 20892, USA"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bldg. 31, Room 1C22, Bethesda, MD 20892, USA"
            }
        ],
        "venue": "Amino acids",
        "year": 2011
    },
    "KKUAzUEQ": {
        "id": "KKUAzUEQ",
        "title": "Synthesis of Co/ M Fe 2 O 4 ( M =Fe, Mn) core/shell nanocomposite particles",
        "abstract": "",
        "keywords": [
            "thermal decomposition",
            "magnetic moment",
            "ferrite",
            "biomedical research",
            "nanocomposites",
            "bioinformatics",
            "surface modification"
        ],
        "authors": [
            {
                "name": "sheng peng",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": "brown university"
            },
            {
                "name": "shouheng sun",
                "org": "brown university"
            }
        ],
        "venue": "Journal of Solid State Chemistry",
        "year": 2008
    },
    "Hhhc5g1P": {
        "id": "Hhhc5g1P",
        "title": "PET/NIRF/MRI triple functional iron oxide nanoparticles.",
        "abstract": "Engineered nanoparticles with theranostic functions have attracted a lot of attention for their potential role in the dawning era of personalized medicine. Iron oxide nanoparticles (IONPs), with their advantages of being non-toxic, biodegradable and inexpensive, are candidate platforms for the buildup of theranostic nanostructures; however, progress in using them has been limited largely due to inefficient drug loading and delivery. In the current study, we utilized dopamine to modify the surface of IONPs, yielding nanoconjugates that can be easily encapsulated into human serum albumin (HSA) matrices (clinically utilized drug carriers). This nanosystem is well-suited for dual encapsulation of IONPs and drug molecules, because the encapsulation is achieved in a way that is similar to common drug loading. To assess the biophysical characteristics of this novel nanosystem, the HSA coated IONPs (HSA-IONPs) were dually labeled with (64)Cu-DOTA and Cy5.5, and tested in a subcutaneous U87MG xenograft mouse model. In vivo positron emission tomography (PET)/near-infrared fluorescence (NIRF)/magnetic resonance imaging (MRI) tri-modality imaging, and ex vivo analyses and histological examinations were carefully conducted to investigate the in vivo behavior of the nanostructures. With the compact HSA coating, the HSA-IONPs manifested a prolonged circulation half-life; more impressively, they showed massive accumulation in lesions, high extravasation rate, and low uptake of the particles by macrophages at the tumor area.",
        "keywords": [
            "multiple imaging",
            "positron emission tomography (pet)",
            "magnetic resonance imaging (mri)",
            "iron oxide nanoparticle (ionp)",
            "enhanced permeability and retention (epr) effect",
            "near-infrared fluorescence (nirf) imaging",
            "near infrared",
            "magnetic resonance imaging",
            "personalized medicine",
            "dopamine",
            "human serum albumin",
            "biocompatible materials",
            "magnetic resonance image",
            "chelating agents",
            "molecular structure",
            "drug carriers"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Jing Huang",
                "org": "Chemistry Department, Beijing University, Beijing, China"
            },
            {
                "name": "Seulki Lee",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA"
            },
            {
                "name": "Jinhua Wang",
                "org": "The Molecular Imaging Program at Stanford, Department of Radiology, Biophysics and Bio-X Program, Stanford University, Stanford, CA, USA"
            },
            {
                "name": "Jinhao Gao",
                "org": "The Molecular Imaging Program at Stanford, Department of Radiology, Biophysics and Bio-X Program, Stanford University, Stanford, CA, USA"
            },
            {
                "name": "Xingguo Li",
                "org": "Chemistry Department, Beijing University, Beijing, China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Biomaterials",
        "year": 2010
    },
    "SX9TGgUc": {
        "id": "SX9TGgUc",
        "title": "Superparamagnetic Nanoparticles: N\u2010Alkyl\u2010PEI\u2010Functionalized Iron Oxide Nanoclusters for Efficient siRNA Delivery (Small 19/2011)",
        "abstract": "",
        "keywords": [
            "small interfering rna"
        ],
        "authors": [
            {
                "name": "gang liu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "jin xie",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "fan zhang",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "zhiyong wang",
                "org": "sichuan university"
            },
            {
                "name": "kui luo",
                "org": "sichuan university"
            },
            {
                "name": "lei zhu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "qimeng quan",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "gang niu",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "seulki lee",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "hua ai",
                "org": "sichuan university"
            },
            {
                "name": "xiaoyuan chen",
                "org": "national institute of biomedical imaging and bioengineering"
            }
        ],
        "venue": "Small",
        "year": 2011
    },
    "x2MadAff": {
        "id": "x2MadAff",
        "title": "In vivo tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots.",
        "abstract": "This article reported the high tumor targeting efficacy of RGD peptide labeled near-infrared (NIR) non-cadmium quantum dots (QDs). After using poly(ethylene glycol) to encapsulate InAs/InP/ZnSe QDs (emission maximum at about 800 nm), QD800-PEG dispersed well in PBS buffer with the hydrodynamic diameter (HD) of 15.9 nm and the circulation half-life of approximately 29 min. After coupling QD800-PEG with arginine-glycine-aspartic acid (RGD) or arginine-alanine-aspartic acid (RAD) peptides, we used nude mice bearing subcutaneous U87MG tumor as models to test tumor-targeted fluorescence imaging. The results indicated that the tumor uptake of QD800-RGD is much higher than those of QD800-PEG and QD800-RAD. The semiquantitative analysis of the region of interest (ROI) showed a high tumor uptake of 10.7 +/- 1.5%ID/g in mice injected with QD800-RGD, while the tumor uptakes of QD800-PEG and QD800-RAD were 2.9 +/- 0.3%ID/g and 4.0 +/- 0.5%ID/g, respectively, indicating the specific tumor targeting of QD800-RGD. The high reproducibility of bioconjunction between QDs and the RGD peptide and the feasibility of QD-RGD bioconjugates as tumor-targeted fluorescence probes warrant the successful application of QDs for in vivo molecular imaging.",
        "keywords": [
            "particle size",
            "integrin",
            "fluorescence imaging",
            "growth factor receptor",
            "quantum dot",
            "near infrared",
            "oligopeptides",
            "peptide",
            "breast cancer",
            "fluorescence",
            "cytotoxicity",
            "quantum dots"
        ],
        "authors": [
            {
                "name": "Jinhao Gao",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Renguo Xie",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Yongjun Yan",
                "org": ""
            },
            {
                "name": "Zhen Cheng",
                "org": ""
            },
            {
                "name": "Xiaogang Peng",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Bioconjugate chemistry",
        "year": 2010
    },
    "kOjc20Mk": {
        "id": "kOjc20Mk",
        "title": "Renal clearing iron oxide nanoparticles for tumor integrin targeting",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "kai chen",
                "org": ""
            },
            {
                "name": "hengyi xu",
                "org": ""
            },
            {
                "name": "sandip biswal",
                "org": ""
            },
            {
                "name": "andrew wang",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "HmMrvtzi": {
        "id": "HmMrvtzi",
        "title": "Assessment and comparison of magnetic nanoparticles as MRI contrast agents in a rodent model of human hepatocellular carcinoma.",
        "abstract": "The purpose of this study was to synthesize, characterize and tailor the surface properties of magnetic nanoparticles with biocompatible copolymer coatings and to evaluate the efficiency of the resulting nanoconjugates as magnetic resonance imaging (MRI) contrast agents for liver imaging. Magnetic nanoparticles with core diameters of 10 and 30 nm were synthesized by pyrolysis and were subsequently coated with a copolymer containing either carboxyl (SHP) or methoxy groups as termini. All four formulas, and ferumoxides (Feridex I.V.(\u00ae)), were individually injected intravenously into separate, normal Balb/C mice (at 2.5, 1.0 and 0.56 mg Fe kg(-1)), and the animals underwent T(2)-weighted MRI at multiple time points post injection (p.i.) to evaluate the hepatic uptake and clearance. Furthermore, we compared the abilities of the new formulas and Feridex to detect tumors in an orthotropic Huh7 tumor model. Transmission electron microscopy (TEM) revealed a narrow size distribution of both the 10 and 30 nm nanoparticles, in contrast to a wide size distribution of Feridex. MTT, apoptosis and cyclin/DNA flow cytometry assays showed that the polymer coated nanoparticles had no adverse effect on cell growth. Among all the tested formulas, including Feridex, SHP-30 showed the highest macrophage uptake at the in vitro level. In vivo MRI studies on normal mice confirmed the superiority of SHP-30 in inducing hypointensities in the liver tissue, especially at clinical dose (0.56 mg Fe kg(-1)) and 3\u2009T field. SHP-30 showed better contrast-to-noise ratio than Feridex on the orthotropic Huh7 tumor model. SHP-30 was found to be an efficient contrast agent for liver MR imaging. The success of this study suggests that, by improving the synthetic approach and by tuning the surface properties of IONPs, one can arrive at better formulas than Feridex for clinical practice.",
        "keywords": [
            "hepatocarcinoma (hcc)",
            "iron oxide nanoparticle (ionp)",
            "liver contrast agent",
            "magnetic resonance imaging (mri)"
        ],
        "authors": [
            {
                "name": "Lihong Bu",
                "org": "Fourth Hospital of Harbin Medical University(Fourth Affiliated Hospital of Harbin Medical University,The Fourth Hospital of Harbin Medical University,Fourth Hospital of Harbin Medical University),Harbin,China"
            },
            {
                "name": "Jin Xie",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Kai Chen",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "Jing Huang",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "Zoraida Pascual Aguilar",
                "org": "Ocean NanoTech, LLC(Ocean NanoTech LLC,Ocean NanoTech. LLC.,Ocean Nanotech, LLC),Fayetteville,United States"
            },
            {
                "name": "Andrew Wang",
                "org": "Ocean NanoTech, LLC(Ocean NanoTech LLC,Ocean NanoTech. LLC.,Ocean Nanotech, LLC),Fayetteville,United States"
            },
            {
                "name": "KinWai Sun",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "MeiSze Chua",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "Samuel So",
                "org": "Stanford University School of Medicine(Stanford University School of Medicine,Stanford Univ. School of Medicine,Stanford Univ. Sch. Med.),Stanford,United States"
            },
            {
                "name": "Zhen Cheng",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Henry S. Eden",
                "org": "Fourth Hospital of Harbin Medical University(Fourth Affiliated Hospital of Harbin Medical University,The Fourth Hospital of Harbin Medical University,Fourth Hospital of Harbin Medical University),Harbin,China"
            },
            {
                "name": "Baozhong Shen",
                "org": "Fourth Hospital of Harbin Medical University(Fourth Affiliated Hospital of Harbin Medical University,The Fourth Hospital of Harbin Medical University,Fourth Hospital of Harbin Medical University),Harbin,China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            }
        ],
        "venue": "Contrast media & molecular imaging",
        "year": 2012
    },
    "GlMYbywA": {
        "id": "GlMYbywA",
        "title": "ENCAPSULATED AGENTS AND METHODS OF MAKING AND USING THEREOF",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "zipeng zhen",
                "org": ""
            },
            {
                "name": "wei tang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "XFpKdN04": {
        "id": "XFpKdN04",
        "title": "pH controlled release of chromone from chromone-Fe3O4 nanoparticles.",
        "abstract": "We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.",
        "keywords": [
            "controlled release",
            "biocompatible materials",
            "dopamine",
            "nanoparticles",
            "solubility"
        ],
        "authors": [
            {
                "name": "Baodui Wang",
                "org": "Brown University(Brown University),Providence,United States"
            },
            {
                "name": "Chenjie Xu",
                "org": "Brown University(Brown University),Providence,United States"
            },
            {
                "name": "Jin Xie",
                "org": "Brown University(Brown University),Providence,United States"
            },
            {
                "name": "Zhengyin Yang",
                "org": "State Key Laboratory of Applied Organic Chemistry(Lanzhou University,State Key Laboratory of Applied Organic Chemistry),Lanzhou,China"
            },
            {
                "name": "Shouheng Sun",
                "org": "Brown University(Brown University),Providence,United States"
            }
        ],
        "venue": "Journal of the American Chemical Society",
        "year": 2008
    },
    "l6eHZpxG": {
        "id": "l6eHZpxG",
        "title": "One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications",
        "abstract": "One-pot reaction of iron(III) acetylacetonate, Fe(acac)3, (or Fe(acac)3 and M(acac)2 where M = Mn and Co), with 1,2-alkanediol, oleic acid, and oleylamine in high boiling organic solvent leads to monodisperse ferrite MFe2O4 nanoparticles. Depending on the concentration of the metal precursors, surfactant-to-metal precursor ratio and the solvent used in the reaction, the particle size from this one-pot reaction can be tuned from 4 to 15 nm. The as-synthesized iron oxide nanoparticles have an inverse spinel structure, and their magnetic properties are controlled by particle size and M in the MFe2O4 structure. The hydrophobic iron oxide nanoparticles are readily transformed into hydrophilic ones by func- tional phospholipid addition to the as-synthesized particles and as a result, the monodisperse nanoparticles are readily functionalized with biotin, -COOH, -SH, and -NH2, facilitating their link to biomolecules for biomedical applications.",
        "keywords": [
            "ferrite nanoparticles",
            "biomedical applications.",
            "surface functionalization",
            "chemical synthesis",
            "phospholipid coating",
            "iron",
            "magnetic properties",
            "particle size"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": "Department of Chemistry|Brown University"
            },
            {
                "name": "Sheng Peng",
                "org": "Department of Chemistry|Brown University"
            },
            {
                "name": "Nathan Brower",
                "org": "Department of Chemistry|Brown University"
            },
            {
                "name": "Nader Pourmand",
                "org": "Stanford Genome Technology Center|Department of Materials Science and Engineering|Department of Electrical Engineering|Stanford University"
            },
            {
                "name": "Shan X. Wang",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": "Department of Chemistry|Brown University"
            }
        ],
        "venue": "Pure and Applied Chemistry",
        "year": 2006
    },
    "7J0F1XCw": {
        "id": "7J0F1XCw",
        "title": "PET imaging of EGFR antibody distribution in head-neck squamous cell carcinoma models",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "gang niu",
                "org": ""
            },
            {
                "name": "zibo li",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "quynhthu le",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "buuHcVJ8": {
        "id": "buuHcVJ8",
        "title": "Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting.",
        "abstract": "A key challenge in developing nanoplatform-based molecular imaging is to achieve an optimal pharmacokinetic profile to allow sufficient targeting and to avoid rapid clearance by the reticuloendothelial system (RES). In the present study, iron oxide nanoparticles (IONPs) were coated with a PEGylated amphiphilic triblock copolymer, making them water soluble and function-extendable. These particles were then conjugated with a near-infrared fluorescent (NIRF) dye IRDye800 and cyclic Arginine-Glycine-Aspartic acid (RGD) containing peptide c(RGDyK) for integrin alpha(v)beta(3) targeting. In vitro binding assays confirmed the integrin-specific association between the RGD-particle adducts and U87MG glioblastoma cells. Successful tumor homing in vivo was perceived in a subcutaneous U87MG glioblastoma xenograft model by both magnetic resonance imaging (MRI) and NIRF imaging. Ex vivo histopathological studies also revealed low particle accumulation in the liver, which was attributed to their compact hydrodynamic size and PEGylated coating. In conclusion, we have developed a novel RGD-IONP conjugate with excellent tumor integrin targeting efficiency and specificity as well as limited RES uptake for molecular MRI.",
        "keywords": [
            "integrin \u03b1 v \u03b2 3",
            "magnetic resonance imaging (mri)",
            "iron oxide nanoparticles (ionps)",
            "rgd peptide",
            "near-infrared fluorescence (nirf) imaging",
            "tumor targeting",
            "water soluble",
            "magnetic resonance image",
            "near infrared",
            "molecular imaging"
        ],
        "authors": [
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Hengyi Xu",
                "org": "Ocean NanoTech LLC, Springdale, AR, USA"
            },
            {
                "name": "Deepak Behera",
                "org": "The Molecular Imaging Program at Stanford, Department of Radiology, Biophysics and Bio-X Program, Stanford University, Stanford, CA, USA"
            },
            {
                "name": "Mark H. Michalski",
                "org": "The Molecular Imaging Program at Stanford, Department of Radiology, Biophysics and Bio-X Program, Stanford University, Stanford, CA, USA"
            },
            {
                "name": "Sandip Biswal",
                "org": "The Molecular Imaging Program at Stanford, Department of Radiology, Biophysics and Bio-X Program, Stanford University, Stanford, CA, USA"
            },
            {
                "name": "Andrew Wang",
                "org": "Ocean NanoTech LLC, Springdale, AR, USA"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Biomaterials",
        "year": 2009
    },
    "7VwlTQq8": {
        "id": "7VwlTQq8",
        "title": "Ultrasmall c(RGDyK)-Coated Fe<sub>3</sub>O<sub>4</sub>Nanoparticles and Their Specific Targeting to Integrin \u03b1<sub>v</sub>\u03b2<sub>3</sub>-Rich Tumor Cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Ha-Young Lee",
                "org": ""
            },
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Andrew R. Hsu",
                "org": ""
            },
            {
                "name": "Sheng Peng",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Journal of The American Chemical Society",
        "year": 2008
    },
    "D3zbs0Gk": {
        "id": "D3zbs0Gk",
        "title": "Monodisperse magnetite nanoparticles coupled with nuclear localization signal peptide for cell-nucleus targeting.",
        "abstract": "Functionalization of monodisperse superparamagnetic magnetite (Fe(3)O(4)) nanoparticles for cell specific targeting is crucial for cancer diagnostics and therapeutics. Targeted magnetic nanoparticles can be used to enhance the tissue contrast in magnetic resonance imaging (MRI), to improve the efficiency in anticancer drug delivery, and to eliminate tumor cells by magnetic fluid hyperthermia. Herein we report the nucleus-targeting Fe(3)O(4) nanoparticles functionalized with protein and nuclear localization signal (NLS) peptide. These NLS-coated nanoparticles were introduced into the HeLa cell cytoplasm and nucleus, where the particles were monodispersed and non-aggregated. The success of labeling was examined and identified by fluorescence microscopy and MRI. The work demonstrates that monodisperse magnetic nanoparticles can be readily functionalized and stabilized for potential diagnostic and therapeutic applications.",
        "keywords": [
            "nuclear localization signal",
            "magnetite",
            "magnetic resonance imaging",
            "nanoparticles"
        ],
        "authors": [
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Nathan Kohler",
                "org": ""
            },
            {
                "name": "Edward\u2005G. Walsh",
                "org": ""
            },
            {
                "name": "Y. Eugene Chin",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Chemistry, an Asian journal",
        "year": 2008
    },
    "o8CHtAan": {
        "id": "o8CHtAan",
        "title": "Chapter 8.2",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "hgjZqgxu": {
        "id": "hgjZqgxu",
        "title": "Production, Modifi cation and Bio-Applications of Magnetic Nanoparticles Gestated by Magnetotactic Bacteria",
        "abstract": "Magnetotactic bacteria (MTB) were first discovered by Richard P. Blakemore in 1975, and this led to the discovery of a wide collection of microorganisms with similar features i.e., the ability to internalize Fe and convert it into magnetic nanoparticles, in the form of either magnetite (Fe3O4) or greigite (Fe3S4). Studies showed that these particles are highly crystalline, monodisperse, bioengineerable and have high magnetism that is comparable to those made by advanced synthetic methods, making them candidate materials for a broad range of bio-applications. In this review article, the history of the discovery of MTB and subsequent efforts to elucidate the mechanisms behind the magnetosome formation are briefl y covered. The focus is on how to utilize the knowledge gained from fundamental studies to fabricate functional MTB nanoparticles (MTB-NPs) that are capable of tackling real biomedical problems.",
        "keywords": [
            "magnetosome",
            "magnetic resonance imaging mri",
            "bio-application",
            "magnetotactic bacteria mtb"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": "Department of Radiology|Stanford University|School of Medicine"
            },
            {
                "name": "Kai Chen",
                "org": "Department of Radiology|Stanford University|School of Medicine"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "Department of Radiology|Stanford University|School of Medicine"
            }
        ],
        "venue": "",
        "year": 0
    },
    "ukqHwVUw": {
        "id": "ukqHwVUw",
        "title": "Nanoparticle Surface Modification and Bioconjugation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": "stanford university"
            },
            {
                "name": "jinhao gao",
                "org": "stanford university"
            },
            {
                "name": "mark h michalski",
                "org": "stanford university"
            },
            {
                "name": "xiaoyuan chen",
                "org": "stanford university"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "hLDpmqwb": {
        "id": "hLDpmqwb",
        "title": "Nanoparticle-based theranostic agents.",
        "abstract": "Theranostic nanomedicine is emerging as a promising therapeutic paradigm. It takes advantage of the high capacity of nanoplatforms to ferry cargo and loads onto them both imaging and therapeutic functions. The resulting nanosystems, capable of diagnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the dawning era of personalized medicine, and much research effort has been devoted toward that goal. A convenience in constructing such function-integrated agents is that many nanoplatforms are already, themselves, imaging agents. Their well-developed surface chemistry makes it easy to load them with pharmaceutics and promote them to be theranostic nanosystems. Iron oxide nanoparticles, quantum dots, carbon nanotubes, gold nanoparticles and silica nanoparticles, have been previously well investigated in the imaging setting and are candidate nanoplatforms for building up nanoparticle-based theranostics. In the current article, we will outline the progress along this line, organized by the category of the core materials. We will focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.",
        "keywords": [
            "gold nanoparticles",
            "quantum dots",
            "emerging technology",
            "quantum dot",
            "molecular imaging",
            "personalized medicine",
            "carbon nanotubes",
            "theranostics",
            "drug carriers",
            "functional integration",
            "nanoparticles",
            "carbon nanotube",
            "developable surface",
            "gene delivery",
            "nanomedicine",
            "diagnostic imaging"
        ],
        "authors": [
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Seulki Lee",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Advanced drug delivery reviews",
        "year": 2010
    },
    "fLxgCXTx": {
        "id": "fLxgCXTx",
        "title": "Ultrasmall near-infrared non-cadmium quantum dots for in vivo tumor imaging.",
        "abstract": "The high tumor uptake of ultrasmall near-infrared quantum dots (QDs) attributed to the enhanced permeability and retention effect is reported. InAs/InP/ZnSe QDs coated by mercaptopropionic acid (MPA) exhibit an emission wavelength of about 800 nm (QD800-MPA) with very small hydrodynamic diameter (<10 nm). Using 22B and LS174T tumor xenograft models, in vivo and ex vivo imaging studies show that QD800-MPA is highly accumulated in the tumor area, which is very promising for tumor detection in living mice. The ex vivo elemental analysis (Indium) using inductively coupled plasma (ICP) spectrometry confirm the tumor uptake of QDs. The ICP data are consistent with the in vivo and ex vivo fluorescence imaging. Human serum albumin (HSA)-coated QD800-MPA nanoparticles (QD800-MPA-HSA) show reduced localization in mononuclear phagocytic system-related organs over QD800-MPA plausibly due to the low uptake of QD800-MPA-HSA in macrophage cells. QD800-MPA-HSA may have great potential for in vivo fluorescence imaging.",
        "keywords": [
            "fluorescence imaging",
            "quantum dots",
            "nanoparticles",
            "diagnostic imaging",
            "quantum dot",
            "cadmium",
            "near infrared"
        ],
        "authors": [
            {
                "name": "Jinhao Gao",
                "org": ""
            },
            {
                "name": "Kai Chen",
                "org": ""
            },
            {
                "name": "Renguo Xie",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Seulki Lee",
                "org": ""
            },
            {
                "name": "Zhen Cheng",
                "org": ""
            },
            {
                "name": "Xiaogang Peng",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Small (Weinheim an der Bergstrasse, Germany)",
        "year": 2010
    },
    "6fMeSwdG": {
        "id": "6fMeSwdG",
        "title": "Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles",
        "abstract": "We demonstrate a magneto-optic technique to measure Brownian relaxation of magnetic nanoparticles suspended in liquids. We used AC susceptibility data as a function of frequency of the applied AC magnetic field to verify that the results agree with those obtained via a conventional inductive detection technique. However, compared with a commercial AC susceptometer using the conventional detection scheme, our magneto-optic setup is able to detect a density of nanoparticles at least three orders smaller. This technique has the potential of being used as a sensor for magnetic nanoparticles such as in local temperature, viscoelasticity, or molecular-binding measurements.",
        "keywords": [
            "biosensing",
            "brownian relaxation",
            "magnetic nanoparticle",
            "ac susceptibility",
            "magneto-optic",
            "magnetic field"
        ],
        "authors": [
            {
                "name": "Seok-Hwan Chung",
                "org": ""
            },
            {
                "name": "Marcos Grimsditch",
                "org": "Materials Science Division, Argonne National Laboratory, Argonne, IL 60439, USA"
            },
            {
                "name": "Axel Hoffmann",
                "org": "Materials Science Division, Argonne National Laboratory, Argonne, IL 60439, USA"
            },
            {
                "name": "Samuel D. Bader",
                "org": "Materials Science Division, Argonne National Laboratory, Argonne, IL 60439, USA"
            },
            {
                "name": "Jin Xie",
                "org": "Department of Chemistry, Brown University, Providence, RI 02912, USA"
            },
            {
                "name": "Sheng Peng",
                "org": "Department of Chemistry, Brown University, Providence, RI 02912, USA"
            },
            {
                "name": "Shouheng Sun",
                "org": "Department of Chemistry, Brown University, Providence, RI 02912, USA"
            }
        ],
        "venue": "Journal of Magnetism and Magnetic Materials",
        "year": 2008
    },
    "oyifQxxN": {
        "id": "oyifQxxN",
        "title": "Flower-like Au-Fe 3 O 4 optical nanosensor for imaging protease expressions in vivo",
        "abstract": "",
        "keywords": [
            "biological activity",
            "molecular imaging",
            "enzymes",
            "nanomedicine",
            "molecular biophysics",
            "surface chemistry",
            "gold",
            "nanosensors",
            "optical imaging",
            "nanocomposites",
            "nanoparticles",
            "nanophotonics",
            "quenching",
            "surface engineering"
        ],
        "authors": [
            {
                "name": "jin xie",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "richard d leapman",
                "org": "national institute of biomedical imaging and bioengineering"
            },
            {
                "name": "xiaoyuan chen",
                "org": "national institute of biomedical imaging and bioengineering"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "vQxUojcQ": {
        "id": "vQxUojcQ",
        "title": "<i>In Vivo</i> MRI Tracking of Cell Invasion and Migration in a Rat Glioma Model",
        "abstract": "Purpose\u00a0\u00a0Malignant brain tumors are characterized by extensive infiltration into the normal brain tissue. Tumor migration is a complicated\n process which results from the interplay of a number of mechanisms, and the extent to which anatomic structure determined\n the migration pattern has not been extensively addressed. In the present study, we labeled C6 glioma cells with iron oxide\n nanoparticles and monitored the fate of the cells in vivo with magnetic resonance imaging (MRI).\n \n \n \n \n Procedures\u00a0\u00a0C6 glioma cells were labeled with ferumoxide\u2013poly-l-lysine complexes and their migration in the brains of rats tracked by T2-weighted MRI. The same amount of iron-laden cells\n were implanted into the caudate nucleus (CN) and at the vicinity of anterior commissure (AC), respectively, and MRI was performed\n during the course of 20-day monitoring period to track tumor growth and migration.\n \n \n \n \n Results\u00a0\u00a0A clear tendency of tumor migration along the white matter fiber tracts was observed in the AC group, which is consistent\n with the previous reports; by contrast, tumor expanded to but remained confined within the boundary of right hemisphere in\n the CN group.\n \n \n \n \n Conclusion\u00a0\u00a0We successfully demonstrated the ability of MRI to investigate the impact of anatomical structure on the glioma migration\n pathway in vivo.",
        "keywords": [
            "glioma",
            "magnetic resonance imaging mri",
            "tumor invasion and migration",
            "cell trafficking",
            "superparamagnetic iron oxide spio nanoparticles"
        ],
        "authors": [
            {
                "name": "Fan Zhang",
                "org": "Department of Radiology, Nanjing Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing, 210002 China"
            },
            {
                "name": "Jin Xie",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA"
            },
            {
                "name": "Gang Liu",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA"
            },
            {
                "name": "Yulong He",
                "org": "Model Animal Research Center, Medical School of Nanjing University, 12 Xuefu Road, Pukou, Nanjing, 210061 China"
            },
            {
                "name": "Guangming Lu",
                "org": "Department of Radiology, Nanjing Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing, 210002 China"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA"
            }
        ],
        "venue": "Molecular Imaging and Biology",
        "year": 0
    },
    "LRuWnfq5": {
        "id": "LRuWnfq5",
        "title": "Synthesis and characterization of PVP-coated large core iron oxide nanoparticles as an MRI contrast agent.",
        "abstract": "The purpose of this study was to synthesize biocompatible polyvinylpyrrolidone (PVP)-coated iron oxide (PVP-IO) nanoparticles and to evaluate their efficacy as a magnetic resonance imaging (MRI) contrast agent. The PVP-IO nanoparticles were synthesized by a thermal decomposition method and characterized by x-ray diffraction (XRD), transmission electron microscopy (TEM), dynamic light scattering (DLS), and a superconducting quantum interface device (SQUID). The core size of the particles is about 8-10 nm and the overall size is around 20-30 nm. The measured r(2) (reciprocal of T(2) relaxation time) and r2\u2217 (reciprocal of T2\u2217 relaxation time) are 141.2 and 338.1 (s mM)(-1), respectively. The particles are highly soluble and stable in various buffers and in serum. The macrophage uptake of PVP-IO is comparable to that of Feridex as measured by a Prussian blue iron stain and phantom study. The signal intensity of a rabbit liver was effectively reduced after intravenous administration of PVP-IO. Therefore PVP-IO nanoparticles are potentially useful for T(2)-weighted MR imaging.",
        "keywords": [
            "prussian blue",
            "x ray diffraction",
            "relaxation time",
            "iron",
            "dynamic light scattering",
            "thermal decomposition",
            "bioinformatics",
            "biomedical research",
            "magnetic resonance image",
            "transmission electron microscopy"
        ],
        "authors": [
            {
                "name": "Ha-Young Lee",
                "org": ""
            },
            {
                "name": "Sang-Hoon Lee",
                "org": ""
            },
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Jin-Hyung Lee",
                "org": ""
            },
            {
                "name": "Bing Wu",
                "org": ""
            },
            {
                "name": "Ai Leen Koh",
                "org": ""
            },
            {
                "name": "Xiaoying Wang",
                "org": ""
            },
            {
                "name": "Robert Sinclair",
                "org": ""
            },
            {
                "name": "Shan X Wang",
                "org": ""
            },
            {
                "name": "Dwight G Nishimura",
                "org": ""
            },
            {
                "name": "Sandip Biswal",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            },
            {
                "name": "Sun Hang Cho",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Nanotechnology",
        "year": 2008
    },
    "nKZAQOvB": {
        "id": "nKZAQOvB",
        "title": "Abstract 4513: Engineering apoferritin nanocages for tumor imaging and therapy.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": "university of georgia"
            },
            {
                "name": "zipeng zhen",
                "org": "university of georgia"
            },
            {
                "name": "wei tang",
                "org": "university of georgia"
            }
        ],
        "venue": "Cancer Research",
        "year": 2013
    },
    "JiJ4I2SI": {
        "id": "JiJ4I2SI",
        "title": "Ferritin nanocages to encapsulate and deliver photosensitizers for efficient photodynamic therapy against cancer.",
        "abstract": "Photodynamic therapy is an emerging treatment modality that is under intensive preclinical and clinical investigations for many types of disease including cancer. Despite the promise, there is a lack of a reliable drug delivery vehicle that can transport photosensitizers (PSs) to tumors in a site-specific manner. Previous efforts have been focused on polymer- or liposome-based nanocarriers, which are usually associated with a suboptimal PS loading rate and a large particle size. We report herein that a RGD4C-modified ferritin (RFRT), a protein-based nanoparticle, can serve as a safe and efficient PS vehicle. Zinc hexadecafluorophthalocyanine (ZnF16Pc), a potent PS with a high (1)O2 quantum yield but poor water solubility, can be encapsulated into RFRTs with a loading rate as high as ~60 wt % (i.e., 1.5 mg of ZnF16Pc can be loaded on 1 mg of RFRTs), which far exceeds those reported previously. Despite the high loading, the ZnF16Pc-loaded RFRTs (P-RFRTs) show an overall particle size of 18.6 \u00b1 2.6 nm, which is significantly smaller than other PS-nanocarrier conjugates. When tested on U87MG subcutaneous tumor models, P-RFRTs showed a high tumor accumulation rate (tumor-to-normal tissue ratio of 26.82 \u00b1 4.07 at 24 h), a good tumor inhibition rate (83.64% on day 12), as well as minimal toxicity to the skin and other major organs. This technology can be extended to deliver other metal-containing PSs and holds great clinical translation potential.",
        "keywords": [
            "nanoparticle",
            "photodynamic therapy",
            "targeted delivery",
            "photosensitizer",
            "ferritin",
            "particle size",
            "drug carriers",
            "nanomedicine",
            "oxygen",
            "dna",
            "zinc",
            "nanoparticles",
            "growth"
        ],
        "authors": [
            {
                "name": "Zipeng Zhen",
                "org": "The University of Georgia(University of Georgia),Athens,United States"
            },
            {
                "name": "Wei Tang",
                "org": "The University of Georgia(University of Georgia),Athens,United States"
            },
            {
                "name": "Cunlan Guo",
                "org": "The University of Georgia(University of Georgia),Athens,United States"
            },
            {
                "name": "Hongmin Chen",
                "org": "The University of Georgia(University of Georgia),Athens,United States"
            },
            {
                "name": "Xin Lin",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Gang Liu",
                "org": "Xiamen University(Xiamen University),Xiamen,China"
            },
            {
                "name": "Baowei Fei",
                "org": "Emory University(Emory University),Atlanta,United States"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institute of Biomedical Imaging and Bioengineering(National Institute of Biomedical Imaging and Bioengineering),Bethesda,United States"
            },
            {
                "name": "Binqian Xu",
                "org": "The University of Georgia(University of Georgia),Athens,United States"
            },
            {
                "name": "Jin Xie",
                "org": "The University of Georgia(University of Georgia),Athens,United States"
            }
        ],
        "venue": "ACS nano",
        "year": 2013
    },
    "aXQlnGVq": {
        "id": "aXQlnGVq",
        "title": "Chimeric ferritin nanocages-based imaging probes",
        "abstract": "Ferritin is a family of proteins found in different forms in most living organisms. Each ferritin is made up of 24 subunits, which self-assemble to form a cage-like nanostructure, with external and internal diameters of 12 and 8 nm, respectively. This unique architecture provides two interfaces\u2014one outside and one inside\u2014for possible functional loading. These interesting features make ferritin a powerful, capacious nanoplatform with potential in a wide spectrum of applications.",
        "keywords": [
            "dye",
            "nanomedicine",
            "bhq-3",
            "biomedical materials",
            "biomedical optical imaging",
            "metal cations",
            "radiation quenching",
            "cy5.5 tagged peptide",
            "nanostructured materials",
            "chimeric ferritin nanocage based imaging probes",
            "proteins",
            "dyes",
            "ferritin proteins family",
            "fluorescence spectroscopy",
            "cage like nanostructure",
            "multimodality imaging probes",
            "molecular biophysics",
            "ferritin nanocage reassembly",
            "compositional control",
            "functional loading",
            "genetically modified ferritin nanocages",
            "multifunctional ferritin nanostructures",
            "function hybridization",
            "black hole quencher",
            "ferritin nanocage disassembly",
            "mmp rich environment",
            "chemically modified ferritin nanocages",
            "plgvr core peptide sequence",
            "imaging",
            "metals"
        ],
        "authors": [
            {
                "name": "Xin Lin",
                "org": "National Institutes of Health (NIH(National Institutes of Health (NIH),,"
            },
            {
                "name": "Jin Xie",
                "org": "National Institutes of Health (NIH(National Institutes of Health (NIH),,"
            },
            {
                "name": "Xiaoyuan Chen",
                "org": "National Institutes of Health (NIH(National Institutes of Health (NIH),,"
            }
        ],
        "venue": "Life Science Systems and Applications Workshop",
        "year": 2011
    },
    "JlvawRNY": {
        "id": "JlvawRNY",
        "title": "PET of EGFR antibody distribution in head and neck squamous cell carcinoma models.",
        "abstract": "Epidermal growth factor receptor (EGFR) is a well-characterized protooncogene that has been shown to promote tumor progression in solid cancers. Clinical results for EGFR targeting with specific monoclonal antibodies (mAbs) such as cetuximab and panitumumab are promising; however, most studies indicate that only a subgroup of patients receiving the mAbs benefit from the immunotherapy, independent of EGFR expression level. To understand the in vivo kinetics of antibody delivery and localization, we performed small-animal PET studies with (64)Cu-labeled panitumumab in xenografts derived from 3 cell lines of human head and neck squamous cell carcinoma (HNSCC).Nude mice bearing HNSCC tumors with different levels of EGFR expression were imaged with small-animal PET using (64)Cu-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)-panitumumab. Antibody distribution in the tumors was confirmed by ex vivo immunostaining using panitumumab and fluorescein 5(6)-isothiocyanate (FITC) panitumumab. CD31 immunostaining and Evans blue assay were also performed to assess the tumor vascular density and permeability.Among these 3 tumor models, UM-SCC-22B tumors with the lowest EGFR protein expression showed the highest (64)Cu-DOTA-panitumumab accumulation, whereas SQB20 tumors with the highest EGFR expression showed the lowest (64)Cu-DOTA-panitumumab accumulation. Ex vivo staining demonstrated that SQB20 cells still had extremely high EGFR expression after forming tumors in nude mice, indicating that the low uptake of (64)Cu-DOTA-panitumumab in SQB20 tumors was not due to the loss of EGFR expression. The results from CD31 immunostaining and Evans blue permeability assay suggest that the low vessel density, poor vascular permeability, and binding site barrier are likely responsible for the overall low tumor uptake of the highly EGFR-expressing SQB20 tumors.The results from this study provide a possible explanation for the lack of an observed correlation between therapeutic efficacy of cetuximab and panitumumab and EGFR expression level as determined by immunohistochemistry or fluorescent in situ hybridization and may shed new light on the complications of anti-EGFR mAb therapy for HNSCC and other malignancies.",
        "keywords": [
            "epidermal growth factor receptor egfr",
            "monoclo- nal antibody mab",
            "head- neck squamous cell carcinoma hnscc",
            "positron emission tomography pet",
            "tumor binding barrier",
            "monoclonal antibody",
            "kinetics",
            "cell line"
        ],
        "authors": [
            {
                "name": "Gang Niu",
                "org": ""
            },
            {
                "name": "Zibo Li",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Quynh-Thu Le",
                "org": ""
            },
            {
                "name": "Xiaoyuan Chen",
                "org": ""
            }
        ],
        "venue": "Journal of nuclear medicine : official publication, Society of Nuclear Medicine",
        "year": 2009
    },
    "xH6OWBTa": {
        "id": "xH6OWBTa",
        "title": "Ultrasmall c(RGDyK)-Coated Fe 3 O 4 Nanoparticles and Their Specific Targeting to Integrin \u03b1 v \u03b2 3 -Rich Tumor Cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jin xie",
                "org": ""
            },
            {
                "name": "kai loon chen",
                "org": ""
            },
            {
                "name": "hayoung lee",
                "org": ""
            },
            {
                "name": "chenjie xu",
                "org": ""
            },
            {
                "name": "andrew r hsu",
                "org": ""
            },
            {
                "name": "sheng peng",
                "org": ""
            },
            {
                "name": "xiaoyuan chen",
                "org": ""
            },
            {
                "name": "shouheng sun",
                "org": ""
            }
        ],
        "venue": "Journal of the American Chemical Society",
        "year": 2008
    },
    "xNqkY3fS": {
        "id": "xNqkY3fS",
        "title": "Conjugating Methotrexate to magnetite (Fe3O4) nanoparticles via trichloro-s-triazine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Kaylie L. Young",
                "org": ""
            },
            {
                "name": "Chenjie Xu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Shouheng Sun",
                "org": ""
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2009
    },
    "fI1KuLKZ": {
        "id": "fI1KuLKZ",
        "title": "On the Strategies of Application-oriented Teacher Team Building in Local Universities",
        "abstract": "The training targeting of local universities is mainly the training of application-oriented undergraduates.This personnel training mode that depends largely on the overall quality of the teachers in local university,should require building an application-oriented teacher team with high-quality,reasonable structure,part and distinct features and relatively stable.But there are some misunderstandings and difficulties on application-oriented teacher team building in local universities.In this regard,it can be promoted by accelerating reform of the basic organization;implementing classified management;increasing the introduction and training of application-oriented high-level talented person;strengthening teacher professional quality training;establishing resource library of part-time teachers;increasing the building of application-oriented professional teaching team and innovation-oriented researching team and so on.",
        "keywords": [
            "strategies",
            "application-oriented teaching team",
            "local university"
        ],
        "authors": [
            {
                "name": "Li Xiaojing",
                "org": "Personal Department,Guangdong Pharmaceutical University,Guangzhou Guangdong ,China"
            },
            {
                "name": "Liu Xiaodan",
                "org": "Personal Department,Guangdong Pharmaceutical University,Guangzhou Guangdong ,China"
            },
            {
                "name": "Li Weidong",
                "org": "Personal Department,Guangdong Pharmaceutical University,Guangzhou Guangdong ,China"
            }
        ],
        "venue": "Journal of Chongqing College of Electronic Engineering",
        "year": 2012
    },
    "g59q79Vh": {
        "id": "g59q79Vh",
        "title": "Reform and Practice on Construction of Colleges and Universities Teachers' Team Internationalization",
        "abstract": "To strengthen the construction of colleges and universities teachers' team internationalization is good for improving the overall international level of schools,improving teaching quality,research level and capacity of social services.In the context of internationalization of higher education,the school implemented the strategy of talents internationalization conscientiously,actively explored the new initiatives in the construction of university teachers' internationalization,made great efforts to building teachers' team,and promoted the school's construction and development greatly.",
        "keywords": [
            "Internationalization",
            "Colleges and universities teachers' team",
            "Reform and practice"
        ],
        "authors": [
            {
                "name": "LI Xiao-Jing",
                "org": "Division of Personnel,Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "LIU Xiao-Dan",
                "org": "Division of Personnel,Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "LI Wei-Dong",
                "org": "Division of Personnel,Guangdong Pharmaceutical University,Guangzhou ,China"
            }
        ],
        "venue": "Pharmaceutical Education",
        "year": 2011
    },
    "Rb1HIIBl": {
        "id": "Rb1HIIBl",
        "title": "Study of Restriction Factors and Safeguarding Mechanism of Industry-Learning-Research Educational Cooperation",
        "abstract": "The paper takes apart the key restriction factors of Industry-Learning-Research educational cooperation at present,and proposes that we could construct safeguarding mechanism of Industry-Learning-Research educational cooperation during reinforcing government leading uphold,consummating organization framework,Clarifying the responsibility and rights and interests of cooperation parties,establishing the cooperation Incentive mechanism,increasing financial input and expanding financing channels,upbuilding an effective evaluation system etc.",
        "keywords": [
            "Restriction factors",
            "Safeguarding Mechanism",
            "Industry-Learning-Research educational cooperation"
        ],
        "authors": [
            {
                "name": "WANG Yan",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "WANG Yiling",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "LI Weidong",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            }
        ],
        "venue": "Pharmaceutical Education",
        "year": 2008
    },
    "TO6p1Uxp": {
        "id": "TO6p1Uxp",
        "title": "Reformation and Practice of the Construction of Teachers' Team in College under the Condition of Higher Education Popularity",
        "abstract": "Higher education popularity is both opportunity to progress and flinty challenge to college.Whether we could grab this opportunity all depends on if we have a team of teachers who are competent for teaching and can surpass any challenge they met.The establishment of a goal of teachers' team construction,which is consistent to the aim of college development,is the most important of all.Under this new condition,our college has brought manpower stratagem into effect,acting energetic in improving teaching power research,and these efforts had come to a good effect.",
        "keywords": [
            "Teachers' team",
            "Colleges",
            "Higher education Popularity"
        ],
        "authors": [
            {
                "name": "LIU Xiaodan",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "ZHU Jiayong",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "HUANG Sixiang",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "LI Weidong",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            },
            {
                "name": "LI Xiaojing",
                "org": "Guangdong Pharmaceutical University,Guangzhou ,China"
            }
        ],
        "venue": "Pharmaceutical Education",
        "year": 2007
    },
    "fYOBBw27": {
        "id": "fYOBBw27",
        "title": "Study of a New Method for Identification to Chinese Herbal Medicine Based on Electronic Nose",
        "abstract": "Objective:The objective in this study is to differentiate varieties of Chinese Herbal medicine in the south of the Five Ridges based on an electronic nose PEN 3 from Airsense Company in Germany,which can exploit information on behavior aroma of different Chinese Herbal medicine.Methods:It used suitable empirical data after the sensors stability and two pattern analysis.Principal component analysis(PCA)and linear discriminant analysis(LDA)were used to investigating nine kinds of different Chinese Herbal medicine in the south of the Five Ridges such as Rhizoma Atractylodis,bergamot,Lesser Galangal Rhizome,citrus chachiensis hortorum,CostusRoot,PummeloPeel,Chinese Mosla Herb,Paniculate Swallowwort Root,Amomum villosum Lour,and so on.Result:The experimental data approve that the system can classify 100% of the total samples using LDA analysis.But,the concentration ratio of those sample distribution map using PCA analysis is lower than using LDA analysis.Some sampling point of Chinese Mosla Herb and Amomum villosum Lour rise up cross-distribution phenomenon in PCA analysis.Conclusion:The results obtained prove that the electronic nose PEN 3 using LDA analysis can discriminate successfully different Chinese Herbal medicine.The technology and method have some meaning and applied value.",
        "keywords": [
            "electronic nose(E-nose)",
            "pattern analysis",
            "identification to Chinese herbal medicine"
        ],
        "authors": [
            {
                "name": "LIU Hong-xiu",
                "org": "College of Medical Information Engineering,Guangdong Pharmaceutical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LUO De-han",
                "org": "Department of Information Engineering,Guangdong University of Technology,Guangzhou ,Guangdong,China"
            },
            {
                "name": "LI Wei-dong",
                "org": "School of Basic Courses,Guangdong Pharmaceutical University,Guangzhou ,Guangdong,China"
            },
            {
                "name": "WANG Yan",
                "org": "Office of Industry,Guangdong Pharmaceutical University,Guangzhou ,Guangdong,China"
            }
        ],
        "venue": "Journal of Liaoning University of Traditional Chinese Medicine",
        "year": 2011
    },
    "R9LIlm8O": {
        "id": "R9LIlm8O",
        "title": "Effect of Long-term Gavage of Folium Sennae on Colic Electromyogram and Interstitial Cells of Cajal in Rats",
        "abstract": "[Objective] To observe the effect of long-term gavage of Folium Sennae (FS) on colic electromyogram and interstitial cells of Cajal (ICC) in rats. [Methods] Forty rats were randomized into normal control group and FS group. The normal control group was fed with conventional forage. FS group was fed with dry forage mixed with FS powder for 3 months, the preliminary dose of FS was 200mg\u00b7kg-1\u00b7d-1 and then increased progressively by 100mg\u00b7kg-1\u00b7d-1 to ensure over half of the rats having diarrhea, and the final dose was 2800 mg\u00b7kg-1\u00b7d-1. The frequency and amplitude of colic slow wave were detected and the changes of myenteric plexus and ICC were observed by zinc iodide -osmic acid staining method. [Results] After long-term gavage of FS, the frequency and amplitude of colic slow wave in rats obviously decreased ( P < 0.05 ) , the distribution of myenteric plexus and ICC was asymmetric and the connection of processes was in a mess. [Conclusion] The decrease of rats colic slow wave frequency induced by long-term gavage of FS may be related to the changes of myenteric plexus and ICC.",
        "keywords": [
            "CONSTIPATION",
            "ANIMAL",
            "COLON/drug effects",
            "FOLIUM SENNAE/pharmacology",
            "RATS",
            "DISEASE MODELS"
        ],
        "authors": [
            {
                "name": "LI Weidong",
                "org": "Dept. of Basic Medicine, Guangdong College of Pharmacy, Guangzhou , China"
            }
        ],
        "venue": "Journal of Guangzhou University of Traditional Chinese Medicine",
        "year": 2005
    },
    "RoxIk2LU": {
        "authors": [
            {
                "name": "H. Li",
                "org": ""
            },
            {
                "name": "W. Yu",
                "org": ""
            },
            {
                "name": "T. Wang",
                "org": ""
            },
            {
                "name": "H. Zhang",
                "org": ""
            },
            {
                "name": "Y. Cao",
                "org": ""
            },
            {
                "name": "E. Abraham",
                "org": ""
            },
            {
                "name": "M.P.Y. Desmulliez",
                "org": ""
            }
        ],
        "title": "Faithful replication of grating patterns in polymer through electrohydrodynamic instabilities",
        "keywords": [
            "electrohydrodynamic instabilities",
            "faithful replication",
            "grating patterns"
        ],
        "venue": "Journal of Micromechanics and Microengineering",
        "year": 2014,
        "id": "RoxIk2LU"
    },
    "91vFQIDw": {
        "authors": [
            {
                "name": "H. Li",
                "org": "University of Chinese Academy of Sciences"
            },
            {
                "name": "W. Yu",
                "org": "State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences"
            },
            {
                "name": "T. Wang",
                "org": "State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences"
            },
            {
                "name": "H. Zhang",
                "org": "State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences"
            },
            {
                "name": "W. Niu",
                "org": "State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences"
            },
            {
                "name": "E. Abraham",
                "org": "MIcroSystems Engineering Centre (MISEC), School of Engineering and Physical Sciences, Heriot-Watt University"
            },
            {
                "name": "M.P.Y. Desmulliez",
                "org": "MIcroSystems Engineering Centre (MISEC), School of Engineering and Physical Sciences, Heriot-Watt University"
            }
        ],
        "title": "Fabrication of micro-optical elements on curved substrates by electrostatic induced lithography",
        "abstract": "This article reports the fabrication and characterization of polymeric micro-optical elements on curved substrates using electrostatic induced lithography. Unlike previous studies focusing upon the pattern formation on planar substrates, we have extended this process by adding it to the micro-transfer molding process to obtain micro-optical elements like diffractive grating and microlenses on curved substrates with aspect ratio greater than 4 : 1. The optical test results of the fabricated micro-optical elements show a slight deviation from theoretical values due to the effect of the curved surface. In comparison with previous reported methods, e.g. laser direct writing or the capillary force lithography method, the method proposed here is faster and more flexible. More importantly, microstructures with high aspect ratio can be easily obtained, which is normally difficult for the two methods reported previously. Therefore, this technology can be used as an effective method for the fabrication of such components with microscale or even nanoscale feature size on curved surfaces. \u00a9 the Partner Organisations 2014.",
        "keywords": [
            ""
        ],
        "venue": "RSC Advances",
        "year": 2014,
        "id": "91vFQIDw"
    },
    "nzTXOrSB": {
        "authors": [
            {
                "name": "Bin Zhao",
                "org": "State Key Laboratory of Plastic Forming Simulation and Die and Mould Technology"
            },
            {
                "name": "Bing An",
                "org": "State Key Laboratory of Plastic Forming Simulation and Die and Mould Technology"
            },
            {
                "name": "Feng-Shun Wu",
                "org": "State Key Laboratory of Plastic Forming Simulation and Die and Mould Technology"
            },
            {
                "name": "Yi-Ping Wu",
                "org": "State Key Laboratory of Plastic Forming Simulation and Die and Mould Technology"
            }
        ],
        "title": "Effects of heating factors on brittle fractures of solder joints by high speed shear test",
        "abstract": "During the solder process, the components, distribution and thickness of intermetallic compound (IMC) between solder and pad can strongly affect the strength of solder joints, which will eventually determine the brittleness of joints. In this paper, the influence of heating factor (Q\u03b7), defined as the integral of the measured temperature over the dwell time above liquidus in the reflow profile on impact toughness of solder joints was evaluated quantitatively by means of High Speed Shear Test (HSST) and conventional Static Shear Test (SST), in which the shear rate was 1.5m/s and 8\u00d710",
        "keywords": [
            "Fracture",
            "Heating factor",
            "High speed shear test",
            "Solder joint",
            "Static shear test"
        ],
        "venue": "2006 7th International Conference on Electronics Packaging Technology, ICEPT '06",
        "year": 2007,
        "id": "nzTXOrSB"
    },
    "MHOH197x": {
        "authors": [
            {
                "name": "Chunyong Zhang",
                "org": "Suzhou Key Laboratory of Environment and Biosafety, Suzhou Academy of Southeast University, Dushuhu Lake Higher Education Town"
            },
            {
                "name": "Liping Liu",
                "org": "Department of Chemistry, College of Science, Nanjing Agricultural University"
            },
            {
                "name": "Wei Li",
                "org": "Department of Chemistry, College of Science, Nanjing Agricultural University"
            },
            {
                "name": "Jingyu Wu",
                "org": "Department of Chemistry, College of Science, Nanjing Agricultural University"
            },
            {
                "name": "Fei Rong",
                "org": "State Key Laboratory of Bioelectronics, Southeast University"
            },
            {
                "name": "Degang Fu",
                "org": "State Key Laboratory of Bioelectronics, Southeast University"
            }
        ],
        "title": "Electrochemical degradation of Acid Orange II dye with boron-doped diamond electrode: Role of operating parameters in the absence and in the presence of NaCl",
        "keywords": [
            "Acid Orange II",
            "Boron-doped diamond",
            "Degradation",
            "Factorial design"
        ],
        "venue": "Journal of Electroanalytical Chemistry",
        "year": 2014,
        "id": "MHOH197x"
    },
    "Z6e6Ejvi": {
        "authors": [
            {
                "name": "Chunyong Zhang",
                "org": "Suzhou Key Laboratory of Environment and Biosafety"
            },
            {
                "name": "Liping Liu",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jinliang Wang",
                "org": "Technical Institute of Physics and Chemistry"
            },
            {
                "name": "Fei Rong",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Degang Fu",
                "org": "State Key Laboratory of Bioelectronics"
            }
        ],
        "title": "Electrochemical degradation of ethidium bromide using boron-doped diamond electrode",
        "keywords": [
            "Boron-doped diamond (BDD)",
            "Degradation",
            "Ethidium bromide (EtBr)"
        ],
        "venue": "Separation and Purification Technology",
        "year": 2013,
        "id": "Z6e6Ejvi"
    },
    "ztXFmkqz": {
        "id": "ztXFmkqz",
        "title": "PP-044 Study on characteristics of Th17 in HBV-associated acute on chronic liver failure patients and the correlation with prognosis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Fang Lin",
                "org": ""
            },
            {
                "name": "Jiyuan Zhang",
                "org": ""
            },
            {
                "name": "Huifen Wang",
                "org": ""
            },
            {
                "name": "Fusheng Wang",
                "org": ""
            }
        ],
        "venue": "International Journal of Infectious Diseases",
        "year": 2009
    },
    "K6SUBBZp": {
        "id": "K6SUBBZp",
        "title": "Longitudinal alteration of circulating dendritic cell subsets and its correlation with steroid treatment in patients with severe acute respiratory syndrome.",
        "abstract": "In this study, we found that 74 patients with severe acute respiratory syndrome (SARS) exhibited a rapid, dramatic decrease in numbers of circulating myeloid and plasmacytoid dendritic cells (mDCs and pDCs) during the first 2 weeks of illness (5.3- and 28.4-fold reductions for mDCs and pDCs compared with 25 healthy individuals, respectively), with slow return to normal cell numbers during convalescence (weeks 5-7 of illness on average). In addition, numbers of circulating CD4 and CD8 T cells exhibited milder reductions (2.1- and 1.8-fold at week 1) and earlier return to normal at a mean of weeks 3 and 4, respectively. A significant inverse correlation was found between numbers of DC and T-cell subsets and high-dose steroid treatment. Our novel findings thus suggest that the acute SARS-coronavirus infection probably contributes to the initial reduction of DC and T-cell subsets in blood, and that high-dose steroid administration may subsequently exacerbate and prolong low expression of the cell subsets. These findings will aid the framing of further studies of the immunopathogenesis of SARS.",
        "keywords": [
            "sars",
            "myeloid dendritic cells",
            "coronavirus",
            "plasmacytoid dendritic cells",
            "steroid",
            "cd8 t cell"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Dongping Xu",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Yonggang Li",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Ming Shi",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Min Wang",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Xianzhi Zhou",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Hao Wu",
                "org": "Beijing You'an Hospital, Capital Medical University, Beijing 100054, China"
            },
            {
                "name": "George F. Gao",
                "org": "Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2005
    },
    "9RTmL5uX": {
        "id": "9RTmL5uX",
        "title": "Changes in circulating Th1 and Th2 cells in patients with chronic HBV infection treated with enticarvir",
        "abstract": "Objective To investigate the change in feature of Th1and Th2cells in the peripheral blood mononuclear cells(PBMCs) of CHB patients during 48weeks of treatment period with enticarvir(ETV),and find the new immune therapy methods.Methods Nine CHB patients(HBV-infected group)diagnosed in 302Hospital of PLA from Nov.2008to Nov.2009,and 9healthy volunteers as control,were enrolled.Serum and PBMCs were obtained from patients in HBV-infected group at the baseline point and 4th,12th,24th, 36th and 48th week during the ETV treatment.HBV markers(HBV-M),HBV DNA and ALT levels in serum were determined. FACSCalibur flow cytometry was performed to detect the cell frequency of Th1and Th2in PMBCs after the intracellular cytokine staining. FACSCalibur software was used to analyze the results.Results There was a significant decrease in ALT and HBV DNA levels in CHB patients at 4th week after ETV treatment.No significant difference was found between CHB patients and healthy controls at 48th week. The frequency of CD3+CD4+IFN-\u03b3+ cells significantly increased at 4th week and gradually decreased later.Until the 48th week,it decreased to approach the baseline,while still higher than that of the counterparts in healthy controls.The frequency of CD3+CD4+IL-4+ cells significantly increased and reached the peak value at 12th week,then decreased and was significantly lower than that in controls at any time point.Conclusion The suppression of HBV replication by ETV may lead to the decrease of Th1immune reaction and insufficiency of Th2immune reaction,which may attenuate the hepatic inflammation and weaken the ability of virus clearing.",
        "keywords": [
            "cellular",
            "antiviral agents",
            "immunity",
            "hepatitis B virus"
        ],
        "authors": [
            {
                "name": "SONG Chun-hui",
                "org": ".Liver Disease Research Center For Biological Therapy,302Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YANG Bin",
                "org": ".Liver Disease Research Center For Biological Therapy,302Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CHEN Li-ming",
                "org": ".Liver Disease Research Center For Biological Therapy,302Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": ".Liver Disease Research Center For Biological Therapy,302Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ".Liver Disease Research Center For Biological Therapy,302Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2010
    },
    "uNvZGTIR": {
        "id": "uNvZGTIR",
        "title": "CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection Potential conflict of interest: The sponsors had no role in the experimental design, data collection, or interpretation.",
        "abstract": "",
        "keywords": [
            "health sciences",
            "hepatology"
        ],
        "authors": [
            {
                "name": "dongling li",
                "org": ""
            },
            {
                "name": "linghua zheng",
                "org": ""
            },
            {
                "name": "lei jin",
                "org": ""
            },
            {
                "name": "yuesu zhou",
                "org": ""
            },
            {
                "name": "haiying li",
                "org": ""
            },
            {
                "name": "junliang fu",
                "org": ""
            },
            {
                "name": "ming shi",
                "org": ""
            },
            {
                "name": "peishuang du",
                "org": ""
            },
            {
                "name": "lizhong wang",
                "org": ""
            },
            {
                "name": "hao wu",
                "org": ""
            },
            {
                "name": "g chen",
                "org": ""
            },
            {
                "name": "pan zheng",
                "org": ""
            },
            {
                "name": "yang liu",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            },
            {
                "name": "shengdian wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "jodmaORb": {
        "id": "jodmaORb",
        "title": "Interleukin-17-producing CD4+ T cells increase with severity of liver damage in patients with chronic hepatitis B",
        "abstract": "Interleukin-17 (IL-17)-producing CD4+ T cells (Th17)-mediated immune response has been demonstrated to play a critical role in inflammation-associated disease; however, its role in chronic hepatitis B virus (HBV) infection remains unknown. Here we characterized peripheral and intrahepatic Th17 cells and analyzed their association with liver injury in a cohort of HBV-infected patients including 66 with chronic hepatitis B (CHB), 23 with HBV-associated acute-on-chronic liver failure (ACLF), and 30 healthy subjects as controls. The frequency of circulating Th17 cells increased with disease progression fromCHB(mean, 4.34%) to ACLF (mean, 5.62%) patients versus healthy controls (mean, 2.42%). Th17 cells were also found to be largely accumulated in the livers of CHB patients. The increases in circulating and intrahepatic Th17 cells positively correlated with plasma viral load, serum alanine aminotransferase levels, and histological activity index. In vitro, IL-17 can promote the activation of myeloid dendritic cells and monocytes and enhance the capacity to produce proinflammatory cytokines IL-1\u03b2, IL-6, tumor necrosis factor (TNF)-\u03b1, and IL-23 in both CHB patients and healthy subjects. In addition, the concentration of serum Th17-associated cytokines was also increased in CHB and ACLF patients. Conclusion: Th17 cells are highly enriched in both peripheral blood and liver of CHB patients, and exhibit a potential to exacerbate liver damage during chronic HBV infection. Copyright \u00a9 2009 by the American Association for the Study of Liver Diseases.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fang Lin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zhengsheng Zou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ruonan Xu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Feng Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ming Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Huifen Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Hepatology",
        "year": 2010
    },
    "HpAa8436": {
        "id": "HpAa8436",
        "title": "Inhibition of expression of CCR5 and CXCR4 on cells by adenovirus-mediated antisense RNA]",
        "abstract": "To suppress the expression of CCR5 and CXCR4, the co-receptors for human immunodeficiency virus type 1 ( HIV-1), and thus inhibit HIV-1 from entering cells.DNA fragments encoding either CCR5 or CXCR4 were amplified from healthy human peripheral blood mononuclear cells (PBMCs) by reverse transcript polymerase chain reaction (RT-PCR) and sequencing was performed. Correct fragments were inserted into Shuttle plasmid inversely, which was recombined with backbone plasmid containing homologous adenoviral genome in E. coli BJ5183. The recombinant plasmids were transfected into 293 cells in which they were packaged and amplified. Recombinant adenoviruses containing antisense RNA of CCR5 or CXCR4 were obtained and identified by RT-PCR, and the titres of them were determined by cytopathic effect (CPE) method. The U937 and MT4 cells were infected by recombinant adenoviruses containing antisense RNA of CCR5 (multiplicity of infection, MOI = 100) and CXCR4 (MOI = 200), respectively. The expression of co-receptors on infected cell was measured by fluorescence activated cell sorter at 24, 48, 72 hours and 10 days after infection. In addition, the chemotactic activity and proliferation of infected cells were detected with Boyden chamber and 3H incorporation respectively.We constructed the recombinant plasmids and obtained the recombinant adenoviruses which contained antisense RNA of CCR5 or CXCR4 and were designated as pAd-antiR5 and pAd-antiX4 respectively. The titers of recombinant adenoviruses pAd-antiR5 and pAd-antiX4 were 5 x 10\" PFU/ml and 7 x 10(10) PFU/ml, respectively. The expression rate of CCR5 on U937 cells decreased from 82. 10% (blank control) to 1.12% (Ad-antiR5 infected) , and that of CXCR4 on MT4 cells decreased from 42% (blank control) to 1.03% (Ad-antiX4 infected) 24 hours later. The expression rates of CCR5 on Ad-antiR5 infected U937 cells were 1.02% , 1.26% , 1.23% at 48 hours, 72 hours, and 10 days later, respectively. The expression rates of CXCR4 on Ad-antiX4 infected MT4 cells were 1.13%, 1.17%, 1.22% at 48 hours, 72 hours, and 10 days later, respectively. Moreover, the recombinant adenovirus had no effects on chemotactic activity and proliferation of the cells.The recombinant adenovirus containing antisense CCR5 or CXCR4 can remarkably decrease the expression of co-receptors for HIV-1 on U937 or MT4 cells without affecting their chemotactic activities and proliferative abilities.",
        "keywords": [
            "co-receptor",
            "inhibition",
            "recombinant adenovirus",
            "antisense rna"
        ],
        "authors": [
            {
                "name": "LI Wen-gang",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            },
            {
                "name": "YU Min",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            },
            {
                "name": "BAI Li",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            },
            {
                "name": "TIAN Xiu-lan",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            },
            {
                "name": "BU Ding-fang",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            },
            {
                "name": "XU Xiao-yuan",
                "org": "Department of Infectious Diseases,Peking University First Hospital,Beijing ,China"
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2006
    },
    "AYGiwTWx": {
        "id": "AYGiwTWx",
        "title": "Association Between Hepatitis B Viral Burden in Chronic Infection and a Functional Single Nucleotide Polymorphism of the <i>PDCD1</i> Gene",
        "abstract": "Background\u00a0\u00a0PD-1, encoded by PDCD1, is highly expressed on virus-specific T cells and plays critical roles in modulating anti-virus immune responses in chronic\n viral infection. It is unknown, however, whether polymorphisms of the PDCD1 are associated with viral clearance during chronic viral infections.\n \n \n \n \n Methodology and principal findings\u00a0\u00a0Here, we used the polymerase chain reaction-restriction fragment length polymorphism method to genotype two single nucleotide\n polymorphisms (SNPs) of PDCD1 in 502 patients with chronic hepatitis B virus (HBV) infection and 359 healthy controls to determine the association between\n PDCD1 genotypes and serum viral load as well as the risk of chronic infection. Our results showed that although neither the P7209C/T SNP site nor the P8737A/G site was associated with the risk of chronic HBV infection, the P7209\n \n T\n  allele in intron 4 is significantly associated with lower viral burden in the blood. Using a luciferase reporter assay, we\n demonstrated that the P7209\n \n T\n  allele creates a negative cis-element for gene transcription.\n \n \n \n \n Conclusions and significance\u00a0\u00a0Our data provide the first evidence that PDCD1 polymorphisms is a genetic factor in pathogenesis of chronic viral infection and reveal the functional significance of the\n P7209 SNP of the PDCD1.",
        "keywords": [
            "pd-1.single-nucleotide polymorphism. hepatitis b virus.viral load"
        ],
        "authors": [
            {
                "name": "Linghua Zheng",
                "org": "Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing, 100101 China"
            },
            {
                "name": "Dongling Li",
                "org": "Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing, 100101 China"
            },
            {
                "name": "Fusheng Wang",
                "org": "Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing, 100101 China"
            },
            {
                "name": "Hao Wu",
                "org": "Departments of Infectious Diseases, Beijing You-An Hospital, Capital Medical University, Beijing, 100054 China"
            },
            {
                "name": "Xiaozhu Li",
                "org": "Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing, 100101 China"
            },
            {
                "name": "Junliang Fu",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Xinyue Chen",
                "org": "Departments of Infectious Diseases, Beijing You-An Hospital, Capital Medical University, Beijing, 100054 China"
            },
            {
                "name": "Lizhong Wang",
                "org": "Division of Immunotherapy, University of Michigan, Ann Arbor, MI 48109, USA"
            },
            {
                "name": "Yang Liu",
                "org": "Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing, 100101 China"
            },
            {
                "name": "Shengdian Wang",
                "org": "Key Laboratory of Infection and Immunity, Institute of Biophysics, Beijing, 100101 China"
            }
        ],
        "venue": "Journal of Clinical Immunology",
        "year": 2010
    },
    "5A1FfKXL": {
        "id": "5A1FfKXL",
        "title": "Tamibarotene: a new hope for therapeutic efficacy in hepatocellular carcinoma patients",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "junliang fu",
                "org": ""
            },
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Hepatology international",
        "year": 2013
    },
    "fQ836pXQ": {
        "id": "fQ836pXQ",
        "title": "Diagnosis of infectious rash",
        "abstract": "Rash may develop in the progression of infectious diseases.This article focuses on the diseases causing rash,the appearance and characteristics of rash and its clinical and laboratory examination.",
        "keywords": [
            "rash",
            "diagnosis",
            "infection"
        ],
        "authors": [
            {
                "name": "ZHOU Zhi-ping",
                "org": " Infectious Diseases Diagnosis and Treatment Center,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YANG Shuo",
                "org": " Infectious Diseases Diagnosis and Treatment Center,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Infectious Diseases Diagnosis and Treatment Center,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "XIE Yang-xin",
                "org": " Infectious Diseases Diagnosis and Treatment Center,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Infectious Diseases Diagnosis and Treatment Center,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2012
    },
    "Q6UZ5mRo": {
        "id": "Q6UZ5mRo",
        "title": "Increased turnover of FoxP3high regulatory T cells is associated with hyperactivation and disease progression of chronic HIV-1 infection.",
        "abstract": "To characterize the homeostasis of CD4FoxP3 regulatory T cells (Treg) and its association with immune hyperactivation in the disease progression of chronic HIV-1 infection.Treg proliferation and apoptosis markers were determined and the relation to disease progression and Treg activation was analyzed.Fifty-six HIV-1-infected highly active antiretroviral therapy (HAART)-naive subjects and 17 HAART-treated subjects were enrolled. Proliferation and apoptosis of Treg from peripheral blood were evaluated by intracellular Ki-67 and active caspase-3 or surface Annexin-V staining. T-cell activation markers, CD38 and HLA-DR, were simultaneously monitored. The effects of in vitro TCR (T cell receptor) stimulation on proliferation, apoptosis, and activation of Treg were determined from both HIV-1-infected subjects and healthy controls.HIV-1-infected patients displayed increased Treg turnover status indicated by higher expression of proliferation marker Ki-67 and apoptosis marker active caspase-3 and Annexin-V. Turnover level of Treg was positively associated with disease progression and immune hyperactivation. In vitro TCR stimulation increased the turnover level of Treg. The HAART treatment decreased the turnover and activation levels of Treg in complete responders.Turnover level of Treg was increased in HIV-1-infected subjects, which is associated with immune hyperactivation and the disease progression, and may serve as a surrogate marker to predict HIV-1 disease progression.",
        "keywords": [
            "hiv-1",
            "regulatory t cells",
            "pathogenesis",
            "homeostasis",
            "foxp3",
            "immune system",
            "apoptosis"
        ],
        "authors": [
            {
                "name": "Shaojun Xing",
                "org": ""
            },
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Yingying Gao",
                "org": ""
            },
            {
                "name": "Yanmei Jiao",
                "org": ""
            },
            {
                "name": "Fubiao Kang",
                "org": ""
            },
            {
                "name": "Jiyuan Zhang",
                "org": ""
            },
            {
                "name": "Chunbao Zhou",
                "org": ""
            },
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Journal of acquired immune deficiency syndromes",
        "year": 2010
    },
    "FT4cNl5X": {
        "id": "FT4cNl5X",
        "title": "Immunological effect and function of B7-homolog1 on diseases",
        "abstract": "B7-homolog1(B7-H1) is one of the important members of costimulatory molecules B7 family and broadly induced in the majority of peripheral tissues as well as lymphocyte.Upon binding to programmed death 1 receptors and an as yet unidentified costimulatory receptor on T-cells and B-cells,B7-H1 may regulate lymphocyte responses in peripheral tissues.The negative regulatory role of B7-H1 has also been documented in human diseases,including cancer,inflammation,allograft rejection,and virus infection.Delineation of the complex interactions between B7-H1 and its receptors as well as its interplay with other ligands is critical for understanding this new immunoregulatory system.Precise manipulation of B7-H1 and its receptors may provide unique opportunities for designing new disease treatments.",
        "keywords": [
            "B7-homolog1",
            "PD-1"
        ],
        "authors": [
            {
                "name": "CHEN Liang-en",
                "org": "Institute of Radiation Medicine,Academy of Military Medical Science,Beijing ,China;Institute of Aviation Medicine,Airforce PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Institute of Infection Diseases,the 302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Journal of Medical Postgraduates",
        "year": 2007
    },
    "e9tXqRnH": {
        "id": "e9tXqRnH",
        "title": "Association between hepatitis B viral burden in chronic infection and a functional single nucleotide polymorphism of the PDCD1 gene.",
        "abstract": "PD-1, encoded by PDCD1, is highly expressed on virus-specific T cells and plays critical roles in modulating anti-virus immune responses in chronic viral infection. It is unknown, however, whether polymorphisms of the PDCD1 are associated with viral clearance during chronic viral infections.Here, we used the polymerase chain reaction-restriction fragment length polymorphism method to genotype two single nucleotide polymorphisms (SNPs) of PDCD1 in 502 patients with chronic hepatitis B virus (HBV) infection and 359 healthy controls to determine the association between PDCD1 genotypes and serum viral load as well as the risk of chronic infection. Our results showed that although neither the P7209(C/T) SNP site nor the P8737(A/G) site was associated with the risk of chronic HBV infection, the P7209 (T) allele in intron 4 is significantly associated with lower viral burden in the blood. Using a luciferase reporter assay, we demonstrated that the P7209 (T) allele creates a negative cis-element for gene transcription.Our data provide the first evidence that PDCD1 polymorphisms is a genetic factor in pathogenesis of chronic viral infection and reveal the functional significance of the P7209 SNP of the PDCD1.",
        "keywords": [
            "hepatitis b virus",
            "pd-1",
            "single-nucleotide polymorphism",
            "viral load",
            "gene transcription",
            "restriction fragment length polymorphism",
            "single nucleotide polymorphism",
            "polymerase chain reaction",
            "immune response",
            "polymorphism"
        ],
        "authors": [
            {
                "name": "Linghua Zheng",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "Dongling Li",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "Hao Wu",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Xiaozhu Li",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Xinyue Chen",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Lizhong Wang",
                "org": "University Michigan Ann Arbor(University of Michigan),Ann Arbor,United States"
            },
            {
                "name": "Yang Liu",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "Shengdian Wang",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            }
        ],
        "venue": "Journal of clinical immunology",
        "year": 2010
    },
    "O8OKXU1A": {
        "id": "O8OKXU1A",
        "title": "Sequential analyses of circulating HBV specific T helper cell response in chronic hepatitis B patients receiving antiviral treatment]",
        "abstract": "To investigate the frequency of circulating HBV specific T helper cell and evaluate its association with serum levels of HBV DNA before and during lamivudine treatment in patients with chronic hepatitis B.The frequency of circulating HBV specific T helper cells in response to HBcAg in 25 chronic HBV-infected patients was determined by Elispot assay; serum HBV DNA was quantitated by real-time PCR.The frequency of HBV specific T helper cell before antiviral treatment (47.30 +/- 25.50 SFCs /1 x 10(6) PBMC) was significantly higher than that at the third month of therapy (23.10 +/- 18.45 SFCs /1 x 10(6) PBMC, P < 0.05). All 8 patients observed dynamically had decreased frequency of HBV specific T helper cell at the third month of therapy; six patients with serum HBV DNA level reduced had higher frequency of HBV specific T helper cell before treatment than 2 patients without serum HBV DNA level decrease.HBV specific T helper cell response at the time of hepatitis flare in chronic hepatitis B patients was significantly augmented compared to that at the time of catabasis.",
        "keywords": [
            "enzyme-linked immunosorbent assay",
            "hepatitis b",
            "helper-inducer",
            "chronic",
            "antiviral agents",
            "t lymphocyte"
        ],
        "authors": [
            {
                "name": "WANG Min",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            },
            {
                "name": "ZHANG Ling-xia",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            },
            {
                "name": "LUO Sheng-qiang",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            },
            {
                "name": "XU Dong-ping",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            },
            {
                "name": "ZHU Chuan-lin",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            },
            {
                "name": "TANG Zi-rong",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". Research Center of Biological Therapy, Institute of Infectious Disease, No.302 Hospital of the People\u2032s Liberation Army, Beijing , China"
            }
        ],
        "venue": "Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology",
        "year": 2005
    },
    "W75w0Xgl": {
        "id": "W75w0Xgl",
        "title": "SARS-associated coronavirus quasispecies in individual patients.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Dongping Xu",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "The New England journal of medicine",
        "year": 2004
    },
    "hWZJcbPQ": {
        "id": "hWZJcbPQ",
        "title": "Hyper-Activated Pro-Inflammatory CD16 + Monocytes Correlate with the Severity of Liver Injury and Fibrosis in Patients with Chronic Hepatitis B",
        "abstract": "",
        "keywords": [
            "chemistry",
            "mononuclear cell",
            "medicine",
            "severity of illness index",
            "young adult",
            "engineering",
            "biology",
            "cell proliferation",
            "physics"
        ],
        "authors": [
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "zhengsheng zou",
                "org": ""
            },
            {
                "name": "ang huang",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "junliang fu",
                "org": ""
            },
            {
                "name": "xiangsheng xu",
                "org": ""
            },
            {
                "name": "liming chen",
                "org": ""
            },
            {
                "name": "baosen li",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "PLOS ONE",
        "year": 2011
    },
    "5pa3SLJN": {
        "id": "5pa3SLJN",
        "title": "Epidemiologic features, clinical diagnosis and therapy of first cluster of patients with severe acute respiratory syndrome in Beijing area]",
        "abstract": "Investigate the features of outbreak epidemic, clinical disease progression of the first SARS cases in Beijing and evaluate the efficacy of therapeutic regimen.Twenty-nine patients (11 men and 18 women, 20 - 74 years old age range) were diagnosed with infectious SARS and admitted in our hospital from the March 5th to April 14th, 2003 in this study. The data of clinical presentation and disease progression of all the patients including index subject as the infectious SARS resource patient, her family infected members and 21 health care workers were abstracted.The first SARA outbreak in Beijing was characterized with the cluster feature of resource patient family members and health care providers. The incubation period ranged from 2 to 14 days. All the patients had a fever (temperature > 38 degrees C for over 24 hours) and other manifestations as reported before. Serial chest radiographs showed progressive pathologic air-space disease. Twenty patients showed the severe syndrome with various time ranged from 1 day to 14 days. Two patients died of progressive acute respiratory distress disease. The histologic analysis of one death patient showed diffuse alveolar damage in the two lungs. Twenty-six patients receiving the combined therapy including use of corticosteroid, antiviral ribavirin agents after the onset of symptoms and showed they had an acute self-limited disease course. The oldest patient (74 year old, male) received the healthy convalescent plasma infusion (50 ml) from recovered SARS subject and completely recovered within 21 days, having a shorter disease course.SARS is a kind of new self-limited and acute infectious disease. Early diagnosis, early isolation, early antiviral therapy for patients and efficient prevention for health care providers are urgently recommended. In particular, a combinational therapy of use of antiviral agents, preventive antibacterial antibiotics and pulsed dosage of corticosteroid can efficiently raise the clinical recovery rate and decrease mortality of SARS patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhou Xian-zhi",
                "org": "302 Hospital of PLA, Beijing 100039, China."
            },
            {
                "name": "Zhao Min",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            },
            {
                "name": "Jiang Tian-jun",
                "org": ""
            },
            {
                "name": "Li Yong-gang",
                "org": ""
            },
            {
                "name": "Nie Wei-min",
                "org": ""
            },
            {
                "name": "Zhou Zhi-ping",
                "org": ""
            },
            {
                "name": "Wang Ye",
                "org": ""
            },
            {
                "name": "He Jing",
                "org": ""
            },
            {
                "name": "Fan Rong",
                "org": ""
            },
            {
                "name": "Zhao Jing-min",
                "org": ""
            },
            {
                "name": "Zhang Xin-wei",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2003
    },
    "XoMc6rlX": {
        "id": "XoMc6rlX",
        "title": "Diagnostic value of routine laboratory test in patients with fever of unknown origin",
        "abstract": "Objective To investigate the diagnostic value of six routine laboratory test items so as to improve confirmative di-agnosis in patients with fever of unknown origin(FUO).Methods A retrospective study was conducted in 132 confirmed FUO pa-tients,who were treated in our hospital from Jan.2002 to Dec.2009.White blood cell count,neutrophils,lymphocytes,erythrocyte sedimentation rate,C-reactive protein and immunoglobulin(IgG,IgM and IgA) were tested upon admission and their relationship with different disease causes were analyzed.Results Of 132 FUO patients,white blood cell count elevated in 55 patients,33(60.0%) of whom had bacterial infection;neutrophil count increased in 29 patients,23(79.3%) of whom had bacterial infection;lymphocytes elevated in 32 patients,15(46.9%) of whom had viral infection,6(18.8%) had hematopathy and solid tumors and 11(34.4%) had rheumatic disease;faster erythrocyte sedimentation rate was found in 61 patients,34(55.7%) of whom had rheumatic disease,15(24.6%) had hematopathy and solid tumors,and 12(19.7%) had infectious diseases;higher C-reactive protein was found in 48 pa-tients,40(83.3%) of whom had infectious disease;immunoglobulin(Ig) G,IgM and IgA increased in 8 patients,who had rheumatic diseases,and 1 or 2 items of IgG,IgM and IgA increased in 26 patients,12(46.2%) of whom had infectious diseases and 14(53.8%) had rheumatic diseases.Conclusions Routine laboratory tests play an important role in the diagnosis of FUO.Careful analysis of laboratory test results can provide evidence for the diagnosis of FUO.",
        "keywords": [
            "laboratory tests",
            "diagnosis",
            "fever of unknown origin"
        ],
        "authors": [
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "NIE Wei-min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "XIE Yang-xin",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHOU Zhi-ping",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "s50cDjUz": {
        "id": "s50cDjUz",
        "title": "Skewed ratios between CD3+ T cells and monocytes are associated with poor prognosis in patients with HBV-related acute-on-chronic liver failure",
        "abstract": "Tempering of the innate immune response by T lymphocytes has been demonstrated to play a critical role in protecting animals from inflammation-induced death; however, its role in humans remains unknown. Patients with HBV-related acute-on-chronic liver failure (ACLF) share a striking similarity to the inflammatory response in septic shock where a hyperactive innate response is observed. The present study attempted to characterize the features of CD3 + T cells and monocytes and evaluate their clinical implications in 55 patients with HBV-related ACLF, 30 patients with chronic hepatitis B (CHB) and 30 healthy controls (HC). We found that the ratio between circulating CD3 + T cells and monocytes (T/M) was decreased in ACLF patients, due to decreased CD3 counts and increased monocyte counts compared with CHB and HC subjects. We also found that the T/M ratios were decreased from the early to the intermediate stage and reached the lowest value at the late stage in ACLF patients. Analyses with clinical parameters revealed that T/M ratios were negatively correlated with the Model for End-Stage Liver Disease Score and direct bilirubin, and positively correlated with prothrombin activity. Moreover, increased T/M ratios were observed in patients with good prognosis, but not in patients with a poor outcome; and ACLF patients who received liver transplantation exhibited an increased T/M ratio. Importantly, we found that programmed death-1 receptor (PD-1) was drastically upregulated on both CD4 + T and CD8 + T cells in ACLF, which at least in part contributed to the T-cell loss in these patients. Mechanically, the in vitro co-culture assay revealed that both CD4 + T and CD8 + T cells, as well as regulatory T cells, could inhibit TNF-\u03b1 secretion by monocytes. In addition, the TNF-\u03b1 levels in ACLF serum were negatively correlated with T/M ratios. In conclusion, our study identified the novel potential role of T/M ratio in predicting disease progression and provided novel evidences for further studies of the immunopathogenesis in ACLF.",
        "keywords": [
            "pd-1",
            "acute-on-chronic liver failure",
            "apoptosis",
            "direct bilirubin",
            "hbv",
            "lipopolysaccharide",
            "tlr",
            "monocyte",
            "toll-like receptor",
            "t/m",
            "lil",
            "lymphocyte",
            "aclf",
            "healthy control",
            "chronic hepatitis b",
            "chb",
            "hc",
            "alt",
            "alanine aminotransferase",
            "lps",
            "ratios between cd3 + t cells and monocytes",
            "pta",
            "hepatitis b virus",
            "liver-infiltrating lymphocytes",
            "peripheral blood mononuclear cells",
            "pbmc",
            "model for end-stage liver disease",
            "prothrombin activity",
            "meld",
            "programmed death-1 receptor",
            "dbil",
            "immune response"
        ],
        "authors": [
            {
                "name": "Feng Shi",
                "org": ""
            },
            {
                "name": "Ji-Yuan Zhang",
                "org": ""
            },
            {
                "name": "Zhen Zeng",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Po Tien",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Biochemical and Biophysical Research Communications",
        "year": 2010
    },
    "7zwKYcAH": {
        "id": "7zwKYcAH",
        "title": "The characteristics of peripheral blood dendritic cells in HBV-infected patients with acute-on-chronic liver failure",
        "abstract": "Objective The functional deficiency of dendritic cell(DC) subsets has been demonstrated to mediate immune impairment and virus persistence in chronic hepatitis B virus(HBV)-infected patients,however,little information of these DCs was available in patients with acute-on-chronic liver failure(ACLF).Methods Forty ACLF patients and 20 CHB patients as well as 20 healthy control(HC)subjects were enrolled into the study.The frequencies,functions and the clinical significance of these DC subsets were analyzed in these patients.Results As compared with CHB and HC subjects,the frequency of peripheral plasmacytoid dendritic cells(pDCs) was significantly decreased in ACLF patients.In addition,the capacity to produce interferon(IFN)-\u03b1of peripheral plasmacytoid pDCs was also significantly reduced in these ACLF patients as compared with CHB and HC subjects.Further analysis indicated that the capacity of pDCs to produce IFN-\u03b1 was significantly higher in survivors than that in non-survivors.More importantly,the capacity of pDCs to produce IFN-\u03b1 was found to be negatively correlated with the disease severity in these ACLF patients.Conclusion The frequency and function of peripheral pDCs were significantly impaired in ACLF patients;pDCs,therefore,may sever as a surrogate marker of disease progression in ACLF patients.",
        "keywords": [
            "Acute-on-chronic liver failure",
            "Plasmacytoid dendritic cells",
            "Interferon-\u03b1",
            "Myeloid dendritic cells"
        ],
        "authors": [
            {
                "name": "ZHANG Wen-jin",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FAN Zhen-ping",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CAI Shao-ping",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "JI Ying-jie",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZOU Zheng-sheng",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " Beijing 302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2010
    },
    "3GPyynbv": {
        "id": "3GPyynbv",
        "title": "{A figure is presented}Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients",
        "abstract": "Background & Aims: Recent studies have suggested that CD4+CD25+ regulatory T cells (Treg) are increased and linked to compromised immune responses in patients with hepatocellular carcinoma (HCC). This study attempted to further characterize CD4+CD25+ forkhead/winged helix transcription factor (FoxP3)+ Treg in blood, tumor, and nontumor liver tissues of HCC patients, and to understand how the Treg affects immune responses and contributes to disease progression. Methods: A total of 123 HCC patients with chronic hepatitis B virus (HBV) infection, 21 HBV-related liver cirrhosis (LC) patients, and 47 normal controls were enrolled randomly. Flow cytometric, immunohistochemical, and immunosuppressive assays were used for analyses of properties of Treg. Multivariate analysis of prognostic factors for overall survival was performed using the Cox proportional hazards model. Results: Circulating CD4+CD25+FoxP3+ Treg frequency was increased significantly and correlated with disease progression in HCC patients. An abundant accumulation of Treg concurrent with significantly reduced infiltration of CD8+ T cells was found in tumor regions compared with nontumor regions. Expression of granzyme A, granzyme B, and perforin was decreased dramatically in tumor-infiltrating CD8+ T cells. Furthermore, Treg of HCC patients inhibited proliferation, activation, degranulation, and production of granzyme A, granzyme B, and perforin of CD8+ T cells induced by anti-CD3/CD28 antibodies. Importantly, an increased quantity of circulating Treg was associated with high mortality and reduced survival time of HCC patients. Conclusions: Increased CD4+CD25+FoxP3+ Treg may impair the effector function of CD8+ T cells, promote disease progression, and represent both a potential prognostic marker and a therapeutic target for HBV-related HCC individuals. \u00a9 2007 AGA Institute.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Dongping Xu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zhenwen Liu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ming Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ping Zhao",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Baoyun Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Huiyin Yang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hui Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Chunbao Zhou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jinxia Yao",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Huifen Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Yongping Yang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "YangXing Fu",
                "org": "University of Chicago(University of Chicago),Chicago,United States"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Gastroenterology",
        "year": 2007
    },
    "7wj1R2o8": {
        "id": "7wj1R2o8",
        "title": "The expression of the surface of PD-L1 on circulating monocyte subsets in chronic hepatitis B patients",
        "abstract": "Objective To investigate the expression of PD-L1 on the surface of circulating monocyte subsets in patients with chronic HBV infection. Methods Immunofluorescent staining and flow cytometry assay were used to measure the expression of PD-L1 on the surface of circulating monocyte subsets from chronic HBV infected patients. Results A significantly positive correlation was found between PD-L1 expression (r=0.358, P=0.035) and serum AST levels, the highest levels of PD-L1 was found on the surface of CD14highCD16+ monocytes(MFI: 16.759.36) from patients in immune active phase. Conclusion PD-L1, which is up-regulated on the surface of monocytes from chronic HBV-infected patients, is positively correlated to serum AST levels, and might play a role in the persistence of HBV infection.",
        "keywords": [
            "PD-L1",
            "chronic",
            "Hepatitis B",
            "Monocytes",
            "CD16"
        ],
        "authors": [
            {
                "name": "HUANG Ang",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "JU Li-zhong",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "SUN Y",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "TENG Guang-ju",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZOU Zheng-sheng",
                "org": ". Department of Hepatopathy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2011
    },
    "bms8Qwb2": {
        "id": "bms8Qwb2",
        "title": "Coronavirus-Specific CTL Epitopes Syndrome-Associated Acute Respiratory Screening and Identification of Severe",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Xiaodong Zhu",
                "org": ""
            },
            {
                "name": "Hua Tao",
                "org": ""
            },
            {
                "name": "Wei He",
                "org": ""
            },
            {
                "name": "Po Tien",
                "org": ""
            },
            {
                "name": "George F. Ming Shan",
                "org": ""
            },
            {
                "name": "Jiaren Tang",
                "org": ""
            },
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Minghai Zhou",
                "org": ""
            },
            {
                "name": "Dongping Xu",
                "org": ""
            },
            {
                "name": "Xiaojuan Li",
                "org": ""
            },
            {
                "name": "Hongtao Li",
                "org": ""
            }
        ],
        "venue": "",
        "year": 0
    },
    "3Xo8jfdK": {
        "id": "3Xo8jfdK",
        "title": "Evaluation on the efficacy of human umbilical cord derived-mesenchymal stem cell transplantation in liver cirrhosis patients with ascites in a prospective and control trial",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hu lin",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "ming shi",
                "org": ""
            },
            {
                "name": "x u ruonan",
                "org": ""
            },
            {
                "name": "f u junliang",
                "org": ""
            },
            {
                "name": "l i yuanyuan",
                "org": ""
            },
            {
                "name": "y u shuangjie",
                "org": ""
            },
            {
                "name": "liming chen",
                "org": ""
            },
            {
                "name": "l sa",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "NP75o75M": {
        "id": "NP75o75M",
        "title": "Changes in regulatory T cells and their relation with prognosis of patients after argon-helium cryoablation for hepatitis B related-hepatocellular carcinoma",
        "abstract": "Objective To investigate the correlation between the percentage of peripheral regulatory T cells (Tregs) and the course of hepatocellular carcinoma (HCC),and analyze the prognostic implication of Tregs in HCC patients undergone argon-helium cryoablation.Methods The percentage of Tregs was determined by flow cytometry,and the correlation between the percentage of Tregs and progression of HCC was then studied.Of 101 patients with HCC,34 underwent argon-helium cryoablation.The Tregs percentage and alpha fetoprotein (AFP) levels in peripheral blood were detected before and after the cryoablation.Subsequently,the variation of Tregs percentage and AFP levels,and the correlation between their variation and the course of HCC was analyzed.Results According to the Barcelona-Clinic Liver Cancer (BCLC) classification,the Tregs was 6.89%\u00b11.27% in patients in early-stage of HCC,9.13%\u00b11.36% in intermediate-stage,10.12%\u00b12.04% in advanced-stage,and 13.4%\u00b12.81% in terminal-stage.After argon-helium cryoablation,the Tregs percentage in 17 patients with regressive tumor was lowered compared with that before cryoablation,and among them both the AFP level and Tregs percentage declined in 7 cases with pre-AFP level >20ng/ml.In addition,the Tregs percentage increased obviously in 14 patients with progression of tumor growth after cryoablation compared with that before cryoablation.Among them both the AFP level and Tregs percentage increased accompanying with the tumor progression in 9 cases with pre-AFP level >20ng/ml.Conclusions The Tregs percentage may increase accompanying progression of the tumor.Argon-helium cryoablation may reduce the Tregs percentage in HCC patients.Increased percentage of Tregs may be considered as a sign for tumor progression,while AFP can not precisely indicate tumor progression in AFP-negative HCC patients.",
        "keywords": [
            "cryosurgery",
            "regulatory",
            "chronic",
            "T-lymphocytes",
            "hepatocellular",
            "hepatitis B",
            "carcinoma"
        ],
        "authors": [
            {
                "name": "ZHOU Lin",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LU Yin-ying",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "GAO Ying-ying",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHOU Chun-bao",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Chun-ping",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "AN Lin-jing",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Xin-zhen",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "SU Shu-hui",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FENG Yong-yi",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YANG Yong-ping",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2010
    },
    "uz1urxY6": {
        "id": "uz1urxY6",
        "title": "Antiviral effects of dual-target antisense rna: an experimental study with hepatitis B virus transgenic mice]",
        "abstract": "To investigate the curative effects of dual-target antisense RNA targeting the X and P regions in the genome of hepatitis B virus (HBV).Retrovirus vector pLXSN was used to construct 4 kinds of recombinant vector plasmids expressing dual-target antisense RNA complementary to the X and P regions in the genome of HBV, namely, pLXSN-asX, pLXSN-asP, pLXSN-asXP, and pLXSN-seX. 48 HBV transgenic mice were randomly divided into 6 equal groups: pLXSN-asX group, pLXSN-asX group, pLXSN-asX group, pLXSN-asX group, and blank plasmid blank (pLXSN) group, to be injected into the caudal vein with corresponding plasmids thrice for every other day, and blank control group. Venous blood samples were collected before, 1 day and 3 days, and 2, 4, and 8 weeks after the injection to undergo detection of serum HBV DNA and HBsAg. Eight weeks later the mice were killed and immunohistochemistry was used t examine the HBsAg and HBcAg in the tissues. Pathological examination of the tissues was performed.The serum HBsAg concentrations 4 and 8 weeks after injection were significantly lower than that before injection in the.pLXSN-asX and pLXSN-asXP groups (all P <0.05) with an inhibition rate of 24% and 27% respectively. In comparison with that before injection, the HBV DNA expression level 2 weeks after injection was significantly lower in the pLXSN-asX group (P < 0.05) with an inhibition rate of 58%. In comparison with that before injection, the HBV DNA expression level 8 weeks after injection was significantly lower in the pLXSN-asP group (P <0.05) with an inhibition rate of 58%. In comparison with that before injection, the HBV DNA expression level in the pLXSN-asXP group showed 2 times of significant decrease 1 week and 8 weeks after injection (both P < 0.05) with the inhibition rates of 66% and 77% respectively. HBsAg and HBcAg were expressed in liver were significantly lower in the pLXSN-asX, pLXSN-asP, and pLXSN-asXP groups than in other groups (P < 0.05). No significant abnormality was found in the tissues in all groups.Dual-target antisense RNA targeting the X and P regions in the genome of HBV inhibits the replication and expression of HBV, significantly stronger than single-target antisense-RNA.",
        "keywords": [
            "transgenic",
            "mice",
            "rna",
            "antisense",
            "hepatitis b virus"
        ],
        "authors": [
            {
                "name": "ZHAO Wei",
                "org": " *Department of Infectious Disease, First Hospital of Beijing University, Beijing , China"
            },
            {
                "name": "CHEN Hong",
                "org": " *Department of Infectious Disease, First Hospital of Beijing University, Beijing , China"
            },
            {
                "name": "PENG Zhao-yuan",
                "org": " *Department of Infectious Disease, First Hospital of Beijing University, Beijing , China"
            },
            {
                "name": "LI Wen-gang",
                "org": " *Department of Infectious Disease, First Hospital of Beijing University, Beijing , China"
            },
            {
                "name": "XI Hong-li",
                "org": " *Department of Infectious Disease, First Hospital of Beijing University, Beijing , China"
            },
            {
                "name": "XU Xiao-yuan",
                "org": " *Department of Infectious Disease, First Hospital of Beijing University, Beijing , China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2005
    },
    "n8WB4hAq": {
        "id": "n8WB4hAq",
        "title": "Importance of reserach and assay of clinical immunology for patients with chronic hepatitis B",
        "abstract": "Host's immune responses play a crucial role in influencing the disease progression and outcome of hepatitis B virus(HBV)infection.Chronic states of hepatitis B patients have been linked to aberrant immune function.HBV specific cellular immune responses are dysfunctional in chronic HBV- infected patients,which included various degree of decrease and functional impairment of dendritic cells, CD_4 helper T cells(Th),CD_8 cytotoxic T lymphocytes(CTL)as well as increase of regulatory T cells (Treg)and enhanced PD-L1/PD-1 signal pathway among immunocytes.The research and assay of clinical immunology could facilitate assessing of the immune status of infection process of the hepatitis B,guidance of clinical antivirus therapies and development of novel immunetherapeutic strategies for patients with chronic HBV infection.",
        "keywords": [
            "Dendritic cells",
            "Hepatitis B virus",
            "Regulatory T cells"
        ],
        "authors": [
            {
                "name": "WANG Fu-sheng",
                "org": " Institute of Infective Disease,People's Liberation Army 302 Hospital,Beijing ,China"
            },
            {
                "name": "CHEN Wei-wei",
                "org": " Institute of Infective Disease,People's Liberation Army 302 Hospital,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Laboratory Medicine",
        "year": 2007
    },
    "cZjpgMeR": {
        "id": "cZjpgMeR",
        "title": "The utilization of fascia dilator in treating child urethral stricture after urethroplasty",
        "abstract": "Objective:To study the utilization of fascia dilator in treating child urethral stricture after urethroplasty.Methods:A retrospective analysis was conducted among 15 patients suffering urethral stricture after urethroplasty.Dilatation via fascia dilator were successfully performed in 12 patients.3 patients were underwent dilatation through ureteroscope.Results:All the patients were successfully underwent dilatation of urethral stricture without complication.Conclusions:Performing dilatation of child urethral stricture via fascia dilator is safe and feasible.",
        "keywords": [
            "urethral stricture",
            "fascia dilator",
            "hypospadias"
        ],
        "authors": [
            {
                "name": "WANG Jian",
                "org": "Department of Urology,303th Hospital of People's Liberation Army,Nanning,,China"
            },
            {
                "name": "ZHOU Daqing",
                "org": "Department of Urology,303th Hospital of People's Liberation Army,Nanning,,China"
            },
            {
                "name": "LI Wengang",
                "org": "Department of Urology,303th Hospital of People's Liberation Army,Nanning,,China"
            },
            {
                "name": "HE Meng",
                "org": "Department of Urology,303th Hospital of People's Liberation Army,Nanning,,China"
            },
            {
                "name": "PANG Xiang",
                "org": "Department of Urology,303th Hospital of People's Liberation Army,Nanning,,China"
            },
            {
                "name": "YU Xiaoxiang",
                "org": "Department of Urology,303th Hospital of People's Liberation Army,Nanning,,China"
            }
        ],
        "venue": "Journal of Clinical Urology",
        "year": 2012
    },
    "3p3qBGJH": {
        "id": "3p3qBGJH",
        "title": "Increased regulatory T cells correlate with CD8 T-cell impairment and poor survival in hepatocellular carcinoma patients.",
        "abstract": "Recent studies have suggested that CD4(+)CD25(+) regulatory T cells (Treg) are increased and linked to compromised immune responses in patients with hepatocellular carcinoma (HCC). This study attempted to further characterize CD4(+)CD25(+) forkhead/winged helix transcription factor (FoxP3)(+) Treg in blood, tumor, and nontumor liver tissues of HCC patients, and to understand how the Treg affects immune responses and contributes to disease progression.A total of 123 HCC patients with chronic hepatitis B virus (HBV) infection, 21 HBV-related liver cirrhosis (LC) patients, and 47 normal controls were enrolled randomly. Flow cytometric, immunohistochemical, and immunosuppressive assays were used for analyses of properties of Treg. Multivariate analysis of prognostic factors for overall survival was performed using the Cox proportional hazards model.Circulating CD4(+)CD25(+)FoxP3(+) Treg frequency was increased significantly and correlated with disease progression in HCC patients. An abundant accumulation of Treg concurrent with significantly reduced infiltration of CD8(+) T cells was found in tumor regions compared with nontumor regions. Expression of granzyme A, granzyme B, and perforin was decreased dramatically in tumor-infiltrating CD8(+) T cells. Furthermore, Treg of HCC patients inhibited proliferation, activation, degranulation, and production of granzyme A, granzyme B, and perforin of CD8(+) T cells induced by anti-CD3/CD28 antibodies. Importantly, an increased quantity of circulating Treg was associated with high mortality and reduced survival time of HCC patients.Increased CD4(+)CD25(+)FoxP3(+) Treg may impair the effector function of CD8(+) T cells, promote disease progression, and represent both a potential prognostic marker and a therapeutic target for HBV-related HCC individuals.",
        "keywords": [
            "granzyme",
            "apc",
            "percp",
            "regulatory t cells",
            "treg",
            "phycoerythrin",
            "gr",
            "peripheral blood",
            "cytolytic t-lymphocyte-associated antigen 4",
            "pe",
            "til",
            "nil",
            "foxp3",
            "fluorescein isothiocyanate",
            "liver cirrhosis",
            "pbmc",
            "ctla-4",
            "forkhead/winged helix transcription factor",
            "peridin chlorophyll protein",
            "lc",
            "non\u2013tumor-infiltrating lymphocytes",
            "tumor-infiltrating lymphocytes",
            "allophycocyanin",
            "pb",
            "peripheral blood mononuclear cell",
            "fitc",
            "cd8 t cell",
            "ctla 4",
            "mononuclear cell",
            "transcription factor"
        ],
        "authors": [
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Dongping Xu",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Zhenwen Liu",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Ming Shi",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Ping Zhao",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Baoyun Fu",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Zheng Zhang",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Huiyin Yang",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Hui Zhang",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Chunbao Zhou",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Jinxia Yao",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Huifen Wang",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Yongping Yang",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Yang-Xing Fu",
                "org": "Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Science, Beijing, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2007
    },
    "p4KImBeL": {
        "id": "p4KImBeL",
        "title": "Current progress in immunopathogenesis and immune modulation for autoimmune hepatitis]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Li Hai-wen",
                "org": "Department of Gastroenterology, Anhui Medical University, Hefei 230000, China."
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Xu Xiang-sheng",
                "org": ""
            },
            {
                "name": "Peng Qiong",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            },
            {
                "name": "Dai Fu",
                "org": ""
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2010
    },
    "KgDSMveU": {
        "id": "KgDSMveU",
        "title": "Decreased ratio of Treg cells to Th17 cells correlates with HBV DNA suppression in chronic hepatitis B patients undergoing entecavir treatment.",
        "abstract": "Treatment with nucleotide analogs is known to be effective in inhibiting HBV replication; however, patients with chronic hepatitis B (CHB) often show a wide range of clinical responses to these drugs. Therefore, the identification of an early immunologic marker associated with the clinical outcomes in such cases is critical for the improved clinical management. In our study, we aimed to investigate whether the viral load in CHB patients affected the ratio of the number of regulatory T cells (Tregs) to the number of interleukin-17-producing helper (Th17) cells. Further, we evaluated the clinical implications of the alterations in this ratio.Nine patients seropositive for hepatitis B e antigen received entecavir monotherapy for 12 months and the percentages of Tregs and Th17 cells as well as the HBV-specific IL-17 productions in these patients were longitudinally analyzed. The entecavir-induced suppression of HBV replication was accompanied by a rapid increase in the number of Th17 cells, together with a decrease in Treg cells, which lead to a significant reduction of Treg/Th17 ratios. In addition, peripheral blood mononuclear cells (PBMCs) exhibited a decreased IL-17 production upon stimulation with the HBV core antigen in vitro.The inhibition of viral replication results in an increase in Th17 cells and concomitant decrease in Treg cells. This imbalance of Treg cells to Th17 cells might have an important role in HBV persistence during entecavir treatment.",
        "keywords": [
            "peripheral blood mononuclear cell",
            "interleukin 17",
            "biology",
            "nucleotides",
            "viral load",
            "chemistry",
            "flow cytometry",
            "engineering",
            "young adult",
            "medicine",
            "physics"
        ],
        "authors": [
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Chunhui Song",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Feng Shi",
                "org": "Institute of Microbiology Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "PloS one",
        "year": 2010
    },
    "ZScjWzUB": {
        "id": "ZScjWzUB",
        "title": "Antitumor activities of human autologous cytokine-induced killer (CIK) cells against hepatocellular carcinoma cells in vitro and in vivo.",
        "abstract": "To characterize the anticancer function of cytokine-induced killer cells (CIK) and develop an adoptive immunotherapy for the patients with primary hepatocellular carcinoma (HCC), we evaluated the proliferation rate, phenotype and the antitumor activity of human CIK cells from healthy donors and HCC patients in vitro and in vivo.Peripheral blood mononuclear cells (PBMC) from healthy donors and patients with primary HCC were incubated in vitro and induced into CIK cells in the presence of various cytokines such as interferon-gamma (IFN-gamma), interleukin-1 (IL-1), IL-2 and monoclonal antibody (mAb) against CD3. The phenotype and characterization of CIK cells were identified by flow cytometric analysis. The cytotoxicity of CIK cells was determined by (51)Cr release assay.The CIK cells were shown to be a heterogeneous population with different cellular phenotypes. The percentage of CD3+/CD56+ positive cells, the dominant effector cells, in total CIK cells from healthy donors and HCC patients, significantly increased from 0.1-0.13% at day 0 to 19.0-20.5% at day 21 incubation, which suggested that the CD3+ CD56+ positive cells proliferated faster than other cell populations of CIK cells in the protocol used in this study. After 28 day in vitro incubation, the CIK cells from patients with HCC and healthy donors increased by more than 300-fold and 500-fold in proliferation cell number, respectively. CIK cells originated from HCC patients possessed a higher in vitro antitumor cytotoxic activity on autologous HCC cells than the autologous lymphokine-activated killer (LAK) cells and PBMC cells. In in vivo animal experiment, CIK cells had stronger effects on the inhibition of tumor growth in Balb/c nude mice bearing BEL-7402-producing tumor than LAK cells (mean inhibitory rate, 84.7% vs 52.8%, P<0.05) or PBMC (mean inhibitory rate, 84.7% vs 37.1%, P<0.01).Autologous CIK cells are of highly efficient cytotoxic effector cells against primary hepatocellular carcinoma cells and might serve as an alternative adoptive therapeutic strategy for HCC patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Ming-Xu Liu",
                "org": ""
            },
            {
                "name": "Bing Zhang",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Zhou-Yun Lei",
                "org": ""
            },
            {
                "name": "Wen-Bing Sun",
                "org": ""
            },
            {
                "name": "Qing-You Du",
                "org": ""
            },
            {
                "name": "Ju-Mei Chen",
                "org": ""
            }
        ],
        "venue": "World journal of gastroenterology : WJG",
        "year": 2002
    },
    "paPVUKqy": {
        "id": "paPVUKqy",
        "title": "Clinical and pathological characteristics and pathogenesis of autoimmune hepatitis]",
        "abstract": "To explore the clinical and pathological characteristics and pathogenesis of autoimmunohepatitis (AIH).The serum and liver biopsy specimens and clinical data of 26 cases with patients with AIH were analyzed and scored according to the criteria of International autoimmune hepatitis (IAIHG, 1999). The changes of dendritic cells (DC) in the liver tissues were observed with a panel of DC markers (CD-80/B7-1, CD-86/B7-2, CD-1a and HLA-DR) and immunohistochemistry, and the activation of hepatic stellate cells (HSC) and the expression of TGF-alpha were also detected. Liver tissue specimens from 10 patients with chronic viral hepatitis B and C respectively and 5 normal liver specimens were chosen as controls.Mean aggregate scores of 26 AIH cases, including 21 cases of type B (80.8%) and 5 cases of type C (19.2%), which were 18.6 +/- 1.4 and 19.1 +/- 2.1 respectively. There were significant differences between the type B and type C in the average age levels of serum ALT and AST, and alpha-Glo (P <0.001 or P< 0.01 or P <0.05). Histological features of all the AIH liver tissues showed the lesions of chronic active hepatitis such as interface hepatitis/piecemeal necrosis (100%), obvious lobular inflammation (type B 95.2%, type C 100%), bridging necrosis (57.1% type B, 80.0% type C, P<0.05), rosetting of liver cells (71.4% type B, 100% type C, P<0.01), central lobular confluent necrosis (33.3% type B, 80.0% type C, P<0.001), predominant plasmacytic infiltration (type B 95.2%, type C 20.0%, P<0.001). The rates of increased and concentrated DC in the portal and lobular areas, especially in the active lesions in type B and type C AIH were 85.7% (18/21) and 5/5 respectively. It was found that DC and lymphocytes surrounded the hepatocytes which partly expressed HLA-DR antigen, while there were no or a few HLA-DR positive hepatocytes in controls. Meanwhile, the number of alpha-SMA positive HSC and the expression of TGF- were obviously increased in AIH liver tissues.Several clinical and pathological features of AIH were identified in this study. As an antigen-presenting cell, DC might play an important role in the pathogenesis of AIH. In China, sub-type B of AIH might be more frequent than sub-type C and there were differences in clinical aspects, serology and pathology between the two types.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhao Jingmin",
                "org": "Department of Pathology, 302nd Hosptital of PLA, Beijing 100039, China."
            },
            {
                "name": "Wang Songshan",
                "org": ""
            },
            {
                "name": "Sun Yanling",
                "org": ""
            },
            {
                "name": "Zhou Guangde",
                "org": ""
            },
            {
                "name": "Liu Ping",
                "org": ""
            },
            {
                "name": "Meng Erhong",
                "org": ""
            },
            {
                "name": "Xin Shaojie",
                "org": ""
            },
            {
                "name": "Zhang Taihe",
                "org": ""
            },
            {
                "name": "Wang Fusheng",
                "org": ""
            },
            {
                "name": "Mao Yuanli",
                "org": ""
            },
            {
                "name": "Li Li",
                "org": ""
            },
            {
                "name": "Li Yingxin",
                "org": ""
            },
            {
                "name": "Zhang Hongfei",
                "org": ""
            },
            {
                "name": "Zhang Lingxia",
                "org": ""
            },
            {
                "name": "Chen Jumei",
                "org": ""
            }
        ],
        "venue": "Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology",
        "year": 2002
    },
    "gbSNDBdl": {
        "id": "gbSNDBdl",
        "title": "One-phase treatment for calculous pyonephrosis by percutaneous nephrolithotomy assisted by EMS LithoClast master.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Wang Jian",
                "org": "Department of Urology, 303th Hospital of People's Liberation Army, Nanning, Guangxi 530021, China."
            },
            {
                "name": "Zhou Da-qing",
                "org": ""
            },
            {
                "name": "He Meng",
                "org": ""
            },
            {
                "name": "Li Wen-gang",
                "org": ""
            },
            {
                "name": "Pang Xiang",
                "org": ""
            },
            {
                "name": "Yu Xiao-xiang",
                "org": ""
            },
            {
                "name": "Jiang Bo",
                "org": ""
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2013
    },
    "jnlCoaib": {
        "id": "jnlCoaib",
        "title": "Identification of immunological effector cells after autologous cytokine-induced killer cells treatment and its clinical implication in hepatocellular carcinoma patients]",
        "abstract": "To investigate the alteration of the cellular profiles of T lymphocyte subsets and dendritic cell subsets in peripheral blood of primary hepatocellular carcinoma (HCC) patients after being transfused with autologous cytokine-induced killer cells (CIK) in patients, then to evaluate the clinical efficacy of the immune therapeutic strategy.Peripheral blood mononuclear cells (PBMCs) from 13 patients with primary were collected using blood cell separator, and expanded in the fresh AIM-V medium in the presence of cytokine cocktail including interferon-gamma (IFN-gamma), monoclonal antibody (mAb) against CD3 and interleukin-2 (IL-2). The phenotypic patterns of CIK cells were longitudinally characterized by flow cytometry on day 0, 4, 7, 10,13 and 15 during the incubation period. PBMCs obtained from HCC patients before or after CIK cells transfusion into bodies to assay the changes of proportion of DC1 or DC2 in peripheral blood.After in vitro incubation for 14 or 15 days, a large of CD3(+)CD56(+) cells were produced from their progenitors and the percentages of CD3(+)CD8(+), CD3(+)CD56(+), CD25(+) cells significantly increased from 33.5% +/- 10.1%, 7.7% +/- 2.8%, and 12.3% +/- 4.5% at the beginning to 36.6% +/- 9.0% (P < 0.05), 18.9% +/- 6.9% (P < 0.01), and 16.4% +/- 5.9% (P < 0.05) at the day 15, respectively. In contrast, the percentages of CD3(+)CD4(+) and NK cells displayed no significant difference. The percentages of CD3(+), CD3(+)CD8(+) cells was held at a higher level during the whole incubation period, however those of the CD25(+), and CD3(+)CD56(+) cells began decreasing on day 7 and day 13, respectively. The proportion of type I of dendritic cells (DC1) and type II of dendritic cells (DC2) subsets increased from 0.59% +/- 0.23% and 0.26% +/- 0.12% before CIK cell transfusion to 0.85% +/- 0.27% and 0.43% +/- 0.20% (all P < 0.01) after CIK cell transfusion. The symptom of HCC patients receiving the CIK cell therapy was markedly ameliorated, and not side effect was seen in the treatment.Our results indicated that autologous CIK cells is able to boost the cellular immunological function in HCC patients, which probably provide a potent immune therapeutic strategy for HCC patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Shi Ming",
                "org": "Division of Biological Engineering, Beijing Institute of Infectious Disease, the 302 Hospital of PLA, Beijing 100039, China."
            },
            {
                "name": "Zhang Bing",
                "org": ""
            },
            {
                "name": "Tang Zi-rong",
                "org": ""
            },
            {
                "name": "Lei Zhou-yun",
                "org": ""
            },
            {
                "name": "Wang Hui-fen",
                "org": ""
            },
            {
                "name": "Feng Yong-yi",
                "org": ""
            },
            {
                "name": "Liu Jin-chao",
                "org": ""
            },
            {
                "name": "Fan Zhen-ping",
                "org": ""
            },
            {
                "name": "Li Han-wei",
                "org": ""
            },
            {
                "name": "Mu Jin-song",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2003
    },
    "4n6n2qvS": {
        "id": "4n6n2qvS",
        "title": "The prediction of immunological dysfunction during antiviral therapy for HCV after liver transplantation: can we improve outcomes?",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "yuanyuan li",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Hepatology international",
        "year": 2013
    },
    "dowwzNxT": {
        "id": "dowwzNxT",
        "title": "Clinical profiles of circulating dendritic cell subsets in chronically HBV-infected patients with interferon-alpha treatment]",
        "abstract": "To investigate the changes of circulating dendritic cell (DC) sunsets in chronic hepatitis B patients treated with alpha-interferon and correlation thereof with therapeutic effectiveness.Twenty-five patients with chronic hepatitis B. 24 males and 1 females, aged 18 approximately 43, were treated with subcutaneous injection of alpha-interferon for 24 weeks and then followed up for another 24 weeks. Blood routine, liver function, renal function, and serum HBV DNA were examined before treatment, and 12, 24, and 48 weeks after beginning of treatment. Peripheral blood samples were collected to detect the DC subsets by flow cytometry.Those patients with complete or partial recovery of alanine transaminase (ALT) and negative seroconversion or decrease of HBV DNA with/without negative seroconversion of HBeAg and HBsAg were grouped as alpha-interferon responders, and those failing to reach the above criteria were grouped as nonresponders. The negative seroconversion rates of HBV DNA and HBeAg, and positive seroconversion rate of anti-HBe were 35%, 40%, and 10 respectively after 24 weeks' treatment and were 40%, 33.3%, and 20% respectively after 48 weeks' treatment. The numbers of myeloid dendritic cells (mDCs) were 16.5 +/- 5.51 x 10(6)/L, 9.86 +/- 5.2 x 10(6)/L, 9.20 +/- 3.19 x 10(6)/L, and 10.0 +/- 3.64 x 10(6)/L respectively in the alpha-interferon responders (P = 0.045); and were 14.41 +/- 6.62 x 10(6)/L, 14.0 +/- 5.27 x 10(6)/L, 10.40 +/- 4.6 x 10(6)/L, and 12.3 +/- 5.23 x 10(6)/L respectively in the non-responders (P = 0.283) before treatment, and after 12, 1 24, and 48 weeks' treatment respectively. The numbers of plasmacytoid dendritic cells (pDCs) were 5.91 +/- 2.35 x 10(6)/L, 4.25 +/- 2.00 x 10(6)/L, 3.30 +/- 1.55 x 10(6)/L, and 4.32 +/- 1.59 x 10(6)/L respectively in the alpha-interferon responders (P = 0.004); and were 5.10 +/- 1.72 x 10(6)/L, 4.06 +/- 1.67 x 10(6)/L, 3.89 +/- 1.25 x 10(6)/L, and 4.06 +/- 8.12 x 10(6)/L respectively in the non-responders before treatment, and after 12, 24, and 48 weeks' treatment respectively ((P = 0.211).Effective on CHB, alpha-interferon induces the percentages and numbers of circulating DC subsets, especially in the-interferon responders.",
        "keywords": [],
        "authors": [
            {
                "name": "Yan Tao",
                "org": "Sixth Department of 302 Hospital of PLA, Beijing 100039, China."
            },
            {
                "name": "Wang Hui-fen",
                "org": ""
            },
            {
                "name": "Ji Wei",
                "org": ""
            },
            {
                "name": "Zhang Ai-min",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Zhang Hui",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2005
    },
    "hbNZXvvA": {
        "id": "hbNZXvvA",
        "title": "HIV-1 subtype B' dictates the AIDS epidemic among paid blood donors in the Henan and Hubei provinces of China.",
        "abstract": "To investigate the genetic background of HIV-1 strains among infected paid blood donors (PBD) in the Henan and Hubei provinces of China.The polymerase chain reaction was used to amplify HIV-1 gag p17 fragments and some 5'-half or full-length viral genomes from peripheral blood mononuclear cells. The HIV-1 sequences obtained were analysed using phylogenetic and recombinant approaches.Among the total of 62 samples studied, 59 (95.2%) came from PBD. Of those 59 PBD, 45 were collected from 14 different geographical locations in Henan, whereas the remaining 14 were from five locations in Hubei. A total of 62 HIV-1 gag p17 fragments, three 5'-half and one full HIV-1 genome sequences were obtained. Phylogenetic analysis of these sequences suggests that PBD from Henan and Hubei, despite being geographically distant, harbored a group of genetically closely related HIV-1 B' strains. No recombinant forms have been detected in this cohort.Our data indicate that the AIDS epidemic among PBD in Henan and Hubei is caused largely by HIV-1 subtype B', which contrasts greatly with the CB' recombinant strains CRF-07 and CRF-08 currently dominating among the drug abusers in other regions of China. Our report has revealed the first complete genome background of the most dominant circulating HIV-1 strain in Henan and Hubei, which is essential for the design and development of an effective AIDS vaccine for the region.",
        "keywords": [
            "hiv-1",
            "subtype b'",
            "henan",
            "china",
            "hubei",
            "paid blood donor",
            "health",
            "polymerase chain reaction",
            "developing countries",
            "genetics",
            "genome sequence",
            "drug abuse",
            "epidemiology",
            "public health",
            "medicine"
        ],
        "authors": [
            {
                "name": "Bo Su",
                "org": ""
            },
            {
                "name": "Li Liu",
                "org": ""
            },
            {
                "name": "Fusheng Wang",
                "org": ""
            },
            {
                "name": "Xien Gui",
                "org": ""
            },
            {
                "name": "Min Zhao",
                "org": ""
            },
            {
                "name": "Po Tien",
                "org": ""
            },
            {
                "name": "Linqi Zhang",
                "org": ""
            },
            {
                "name": "Zhiwei Chen",
                "org": ""
            }
        ],
        "venue": "AIDS (London, England)",
        "year": 2003
    },
    "p0I7xNv4": {
        "id": "p0I7xNv4",
        "title": "PP-150 To investigate the change of peripheral dendritic cell (DC) subsets in individuals infected with HIV who were treated with Ailing granule, a traditional Chinese drug",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Jianan Wei",
                "org": ""
            },
            {
                "name": "Jing Liu",
                "org": ""
            },
            {
                "name": "Fusheng Wang",
                "org": ""
            },
            {
                "name": "Chunxin Song",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Yan Jin",
                "org": ""
            },
            {
                "name": "Liuhua Xue",
                "org": ""
            },
            {
                "name": "Wei Zhou",
                "org": ""
            },
            {
                "name": "Xuan Xu",
                "org": ""
            },
            {
                "name": "Xiazhen Huang",
                "org": ""
            }
        ],
        "venue": "International Journal of Infectious Diseases",
        "year": 2009
    },
    "iTEEGTx6": {
        "id": "iTEEGTx6",
        "title": "Novel therapeutic strategy on immunological non-responders with HIV infection: how to resolve the clinical problem",
        "abstract": "Immunological non-response, generally occurring during antiviral therapy in patients with chronic HIV infection, displays high morbidity and mortality. No consensus has been reached regarding when or how to treat immunological non-responders (INRs). This review summarizes the current novel therapeutic strategies on how to reverse the immune or T cell deficiency in INRs, such as adoptive T cell transfusion, cytokine therapy, novel approach targeting immune over-activation and chemokine receptor 5-modified immune reconstitution as well.",
        "keywords": [
            "interleukins",
            "therapeutics",
            "immunological non-response",
            "acquired immunodeficiency syndrome"
        ],
        "authors": [
            {
                "name": "ZHANG Zheng",
                "org": "* Liver Disease Research Center for Biological Therapy, Institute of Translational Hepatology, 302 Hospital of PLA, Beijing , China"
            },
            {
                "name": "WANG Fu-Sheng",
                "org": "* Liver Disease Research Center for Biological Therapy, Institute of Translational Hepatology, 302 Hospital of PLA, Beijing , China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2012
    },
    "AJViU8P3": {
        "id": "AJViU8P3",
        "title": "Detection and the production mechanism of antinuclear antibodies (ANA) and anti-liver/kidney microsomal type 1 antibodies (anti-LKM1) in patients with chronic hepatitis C.",
        "abstract": "",
        "keywords": [
            "autoantibodies"
        ],
        "authors": [
            {
                "name": "bai li",
                "org": ""
            },
            {
                "name": "lu haiying",
                "org": ""
            },
            {
                "name": "feng zhenru",
                "org": ""
            },
            {
                "name": "yu min",
                "org": ""
            },
            {
                "name": "li wengang",
                "org": ""
            },
            {
                "name": "gong weirbo",
                "org": ""
            },
            {
                "name": "zhao nuenjiya",
                "org": ""
            },
            {
                "name": "xu xiaoyuan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "ybLqFeuW": {
        "id": "ybLqFeuW",
        "title": "Cytokine-induced killer(CIK)cells in vitro incubation from patients with chronic hepatitis C and cell subsets analysis",
        "abstract": "Objective To explore the changes of the immune cell subsets during the process of cytokine-induced killer(CIK)cell incubation from patients with chronic hepatitis C.Methods Peripheral blood mononuclear cells (PBMC)from patients with chronic hepatitis C were in vitro incubated supplementing with cytokine cocktail(rhIFN-\u03b3, IL-2 and\u03b1-CD3).On days at 0,7,10,13 and 15,the incubated cells were collected and flow cytometry was performed to determine the frequencies of immune cell subsets.Results The frequencies of CD3+ cells increased quickly and reached the top values on the 10th day.The frequencies of CD3+CD8+ and CD3+CD56+ cells kept increasing during the cultureing procedure both in the patients with immune tolerant and immune active phase,which appearing strong capacity of proliferation.Conclusion CIK cells from patients with chronic hepatitis C would be suitable for autologous transfusion after in vitro incubation on the 10th day with higher levels of proliferation of CD3+ and high cell proliferation states of CD3+CD8+ and CD3+CD56+ cells.",
        "keywords": [
            "Cytokine-induced killer cell",
            "Chronic hepatitis C",
            "Immune cell subset"
        ],
        "authors": [
            {
                "name": "ZHANG Bing",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "SHI Ming",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "XIE Yun-bo",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "WANG Si-yu",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "TANG Zi-rong",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2012
    },
    "j6yoaldm": {
        "id": "j6yoaldm",
        "title": "In vitro detection of the frequency of human Th17 cells",
        "abstract": "Objective To investigate the effect of different stimulated objects, different stimulating concentrations, different protein transportation inhibitors on the frequency of human Th17 cells. Methods Whole blood or peripheral blood mononuclear cells (PBMC) were stimulated by PMA at different concentrations(25, 50, 150, 300, 500, 750, and 1 000ng/mL). Ionomycin, different protein transportation inhibitors (BFA or Monensin) were added after 1h and then Th17 cells were detected after different stimulating time points (3, 6, and 9h). Results The stimulating effect of whole blood was better than PBMC(P<0.05). The best final concentration of PMA stimulating the whole blood was 300ng/mL. BFA and Monensin had a similar inhibitory effect on IL-17 secretion, but influenced the process of hemolysis differently. Six hours were found to be more suitable to stimulate the whole blood. Conclusion Stimulating whole blood with PMA (300ng/mL) and Ionomycin, with 2\u03bcmol/L Monensin added after 1h and incubated for 6h, can detect the frequency of human Th17 cells.",
        "keywords": [
            "methods",
            "cells",
            "flow cytometry",
            "Th17"
        ],
        "authors": [
            {
                "name": "HUANG Ang",
                "org": "Student Team, Chinese PLA General Hospital, Beijing , China;Fourth Department of Infectious Diseases, Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": " Institute of Infectious Diseases, Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " Institute of Infectious Diseases, Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " Institute of Infectious Diseases, Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "ZOU Zheng-sheng",
                "org": "Fourth Department of Infectious Diseases, Chinese PLA 302 Hospital, Beijing , China"
            }
        ],
        "venue": "Journal of Chinese PLA Postgraduate Medical School",
        "year": 2010
    },
    "gr1YP9jE": {
        "id": "gr1YP9jE",
        "title": "The effect of human umbilical cord derived-mesenchymal stem cells transplantation on patients with decompensated liver cirrhosis:a prospective and control trial",
        "abstract": "Objective To evaluate the safety and therapeutic efficiency of human umbilical cord derived-mesenchymal stem cells(UC-MSCs) treating patients with decompensated liver cirrhosis.Methods UC-MSCs were identified by morphology,surface markers and differentiation potential which were transplanted into patients with decompensated liver cirrhosis intravenously.The serum Alb,ascites and MELD scores were detected at different time points after UC-MSCs transplantation.Results The quality of life in most patients transplanted with UC-MSCs were improved to varying degrees.Beside low-grade fever in few patients,no other side effects or oncogenecity was found.It was found that the Alb levels were significantly increased while the ascites were significantly decreased.But MELD scores were not significantly decreased after 48w transplatation in patients with decompensated liver cirrhosis underlying UC-MSCs treatment.In addition,the index of the ascites was found to be changed more pronouncedly in the UC-MSCs group as compared with the control groups.Conclusion UC-MSCs transplantation displayed good safety and efficiency in patients with decompensated liver cirrhosis in clinic.",
        "keywords": [
            "Hepatocyte",
            "Mesenchymal stem cells",
            "Transplantation",
            "Liver cirrhosis"
        ],
        "authors": [
            {
                "name": "LIN Hu",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "SHI Ming",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "XU Ruo-nan",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "GENG Hua",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "LI Yuan-yuan",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "YU Shuang-jie",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "CHEN Li-ming",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "LV Sa",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            },
            {
                "name": "WANG Fu-Sheng",
                "org": ".The Research Center for Biological Therapy,302 Hospital,Beijing ,China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2012
    },
    "tCXMA7Qr": {
        "id": "tCXMA7Qr",
        "title": "HBcAg-Pulsed Monocyte-Derived Dendritic Cells from HBV-Associated Hepatocellular Carcinoma Patients Treated with Supernant from CPG-ODN2216-Pulsed PBMC Significantly Enhance HBV Specific T-Cells Response in vitro",
        "abstract": "Objective:To investigate the roles of supernant from CpG-ODN2216-pulseded peripheral blood mononuclear cells(PBMC)potentiating HBcAg-pulsed dendritic cells(DC)from HBV-associated hepatocellular carcinoma(HCC)patients maturation and function.Methods:Monocyte-derived DC(MoDC)from 9 HBV-associated HCC patients were pulsed with HBcAg,and promoted maturation with \u2033cytokine cocktails\u2033 composed of TNF-\u03b1,IL-6,IL-1\u03b2,PGE2 only(G1),supernatant of PBMC stimulated with CpG-ODN2216(G2),and cytokine cocktails combined with supernatant of PBMC stimulated with CpG-ODN2216(G3).Phenotype and function of mature MoDC were characterized.HBV-specific CD8+ T cells were induced by mature MoDC in autologous T cells from 5 cases of HLA-A2+ patients.Results:CD80/CD83/CD1a expressions on HBcAg-pulsed MoDC were significantly higher in G3 than those in G1 and G2.The levels of IL-12 and IL-10 produced by mature HBcAg-pulsed MoDC in G3 were higher than those in G1 and G2,and same pattern was in IFN-\u03b3/TNF-\u03b1/IL-6 secretion by autologous T cells co-cultured with MoDC.HBV core18-27-epitope specific CD8+ T cells could be induced in 3 cases of 5 patients in vitro,and the frequencies of specific CD8+ T cells induced by mature MoDC in G3 were higher than those in G1.Conclusion:cytokine cocktails combined with supernatant of PBMC stimulated with CpG-ODN2216 can significantly promote HBcAg-pulsed MoDC maturation and cytokines secretion,and capacity of autologous T cells stimulation,inducing HBV-specific CD8+ T cells in HBV-associated HCC patients in vitro,and may be a feasible method to improve the HBV-specific DC vaccine.",
        "keywords": [
            "dendritic cells",
            "hepatitis B virus",
            "hepatocellular carcinoma"
        ],
        "authors": [
            {
                "name": "CHEN Wei-wei",
                "org": "b 1.PLA Postgraduate Medical School,Beijing ;a.Third Department of Infectious Disease,b.Research Center of Biological Therapy,302 Hospital of PLA,Beijing "
            },
            {
                "name": "SHI Ming",
                "org": "a.Third Department of Infectious Disease,b.Research Center of Biological Therapy,302 Hospital of PLA,Beijing "
            },
            {
                "name": "FU Jun-liang",
                "org": "a.Third Department of Infectious Disease,b.Research Center of Biological Therapy,302 Hospital of PLA,Beijing "
            },
            {
                "name": "ZHANG Bing",
                "org": "a.Third Department of Infectious Disease,b.Research Center of Biological Therapy,302 Hospital of PLA,Beijing "
            },
            {
                "name": "XIN Shao-jie",
                "org": "a.Third Department of Infectious Disease,b.Research Center of Biological Therapy,302 Hospital of PLA,Beijing "
            },
            {
                "name": "WANG Fu-sheng",
                "org": "a.Third Department of Infectious Disease,b.Research Center of Biological Therapy,302 Hospital of PLA,Beijing "
            }
        ],
        "venue": "Letters in Biotechnology",
        "year": 2007
    },
    "TdaVxnMq": {
        "id": "TdaVxnMq",
        "title": "The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8+ T cells in HIV-1-infected typical progressors, but not in long-term non-progressors.",
        "abstract": "Persistent HIV infection results in a decrease in absolute counts of CD4(+) CD25(+) regulatory T cells (Treg). To investigate the role of decreased Treg counts in the regulation of excessive activation and apoptosis of CD8(+) T cells in human immunodeficiency virus (HIV)-1 infection, we characterized Treg in 83 HIV-1-infected individuals, including 19 long-term non-progressors (LTNPs) and 51 typical progressors (TPs) who were treatment-na\u00efve, and 13 AIDS patients on highly active antiretroviral therapy (HAART), of whom nine were complete responders (CRs) and the remaining four were non-responders (NRs) to the treatment. TPs but not LTNPs had a significant decrease in absolute counts of circulating Treg, which was inversely correlated with the activation and apoptosis of CD8(+) T cells. Efficient HAART was found to increase Treg counts in CR patients and temper the excessive activation and apoptosis of CD8(+) T cells. Moreover, isolated Treg significantly inhibited the spontaneous and anti-CD3-induced apoptosis of CD8(+) T cells in a dose-dependent manner in vitro. Thus, our findings indicate that the decrease in Treg closely correlates with the increase in apoptotic CD8(+) T cells and disease progression in chronic HIV-1 infection, and that Treg may play a key role in maintaining the balance between the amount and quality of CD8(+) T cells in HIV-1 infection. Manipulation of Treg function may be a promising strategy for immune therapy of this disease.",
        "keywords": [
            "apoptosis",
            "hiv-1 infection",
            "t cells",
            "tolerance/suppression/anergy"
        ],
        "authors": [
            {
                "name": "Yanmei Jiao",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Shaojun Xing",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Baoyun Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ming Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Xicheng Wang",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fubiao Kang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hao Wu",
                "org": "Capital Medical University China(Capital University of Medical Sciences,Capital Medical University),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Immunology",
        "year": 2009
    },
    "IoKya4Hk": {
        "id": "IoKya4Hk",
        "title": "Analysis the frequency and function of HBV-specific CD8 positive cytocytoxic T lymphocytes from PBMCs in patients with hepatitis B",
        "abstract": "Objective To analyze the frequency and the function of HBV-specific CTLs in peripheral blood from 36 cases of HLA-A2+ HBV-infected patients using Tetramer and IFN-\u03b3-ELISPOT assays. Methods The patients enrolled were categorized into two groups named after acute hepatitis B (AHB, 12 cases)and chronic hepatitis B(CHB,24 cases).Peripheral blood mononuclear cells (PBMCs) were isolated via ingredient centrifugation and used for CTL analysis. Three commercial tetramer reagents specifically conjugated with epitopes of HBcAg 18-27(Tc18-27), HBsAg 183-191(Ts183-191) and polymerase 575-583(Tp575-583),respectively, were purchased for analysis the frequencies of HBV-specific CTLs. Furthermore, the assay of ELISPOT was used for analyzing the secreting functions of IFN-\u03b3 for CTLs. Results Though no significant difference in Tc18-27-reactive CTLs was between the patients with AHB and CHB, the mean and the positive rate of Ts183-191-specific CTL in AHB were significantly higher than that in the CHB groups(0.24%\u00b10.39% vs 0.03%\u00b10.02% and 75% vs 33.3%,P<0.05),and so were the Tp575-583-specific CTLs(0.08%\u00b10.09% vs 0.02%\u00b10.01% and 50% vs 16.7%). Moreover, averaged 1.58 of 3 tetramers was positive in the patients with AHB, which was higher than that in CHB with a mean value of 0.67. Furthermore, the absolute amounts of Tetramer-positive CTL were positively correlated with IFN-\u03b3-producing cell numbers measured by ELISPOT in AHB patients under the stimulation of HBV correspondingly peptide such as s183-191(P<0.01). Conclusion Our findings suggest that HBV-specific CTLs may play an important role in controlling the HBV replication through producing IFN-\u03b3, which can be one of the main contents for immunotherapy of CHB.",
        "keywords": [
            "Tetramer",
            "Cytocytoxic T lymphocytes",
            "Hepatitis B",
            "ELISPOT"
        ],
        "authors": [
            {
                "name": "FAN Zhen-ping",
                "org": ". Department of Liver Disease Center for Military Staf f, 302 Military Hospital, Beijing , China"
            },
            {
                "name": "SHI Ming",
                "org": ". Department of Liver Disease Center for Military Staf f, 302 Military Hospital, Beijing , China"
            },
            {
                "name": "XU Dong-ping",
                "org": ". Department of Liver Disease Center for Military Staf f, 302 Military Hospital, Beijing , China"
            },
            {
                "name": "ZHANG Wen-jin",
                "org": ". Department of Liver Disease Center for Military Staf f, 302 Military Hospital, Beijing , China"
            },
            {
                "name": "ZHANG Ling-xia",
                "org": ". Department of Liver Disease Center for Military Staf f, 302 Military Hospital, Beijing , China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". Department of Liver Disease Center for Military Staf f, 302 Military Hospital, Beijing , China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2012
    },
    "csNFscnp": {
        "id": "csNFscnp",
        "title": "Hyper-activated pro-inflammatory CD16 monocytes correlate with the severity of liver injury and fibrosis in patients with chronic hepatitis B.",
        "abstract": "Extensive mononuclear cell infiltration is strongly correlated with liver damage in patients with chronic hepatitis B virus (CHB) infection. Macrophages and infiltrating monocytes also participate in the development of liver damage and fibrosis in animal models. However, little is known regarding the immunopathogenic role of peripheral blood monocytes and intrahepatic macrophages.The frequencies, phenotypes, and functions of peripheral blood and intrahepatic monocyte/macrophage subsets were analyzed in 110 HBeAg positive CHB patients, including 32 immune tolerant (IT) carriers and 78 immune activated (IA) patients. Liver biopsies from 20 IA patients undergoing diagnosis were collected for immunohistochemical analysis. IA patients displayed significant increases in peripheral blood monocytes and intrahepatic macrophages as well as CD16(+) subsets, which were closely associated with serum alanine aminotransferase (ALT) levels and the liver histological activity index (HAI) scores. In addition, the increased CD16(+) monocytes/macrophages expressed higher levels of the activation marker HLA-DR compared with CD16(-) monocytes/macrophages. Furthermore, peripheral blood CD16(+) monocytes preferentially released inflammatory cytokines and hold higher potency in inducing the expansion of Th17 cells. Of note, hepatic neutrophils also positively correlated with HAI scores.These distinct properties of monocyte/macrophage subpopulations participate in fostering the inflammatory microenvironment and liver damage in CHB patients and further represent a collaborative scenario among different cell types contributing to the pathogenesis of HBV-induced liver disease.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zhengsheng Zou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ang Huang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Xiangsheng Xu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Liming Chen",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Baosen Li",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "PloS one",
        "year": 2011
    },
    "NyTTZNZq": {
        "id": "NyTTZNZq",
        "title": "Changes of peripheral plasmacytoid dendritic cells and lymphocyte subsets in chronic hepatitis B patients treated with consensus interferon alpha]",
        "abstract": "To study the changes of peripheral plasmacytoid dendritic cells and lymphocyte subsets in patients with chronic hepatitis B (CHB) during consensus interferon (CIFN) treatment.Twenty-three patients with CHB were treated with CIFN for 24 weeks and followed up for another 24 weeks. Peripheral plasmacytoid dendritic cells and lymphocyte subsets were measured throughout the treatment and follow-up periods.After CIFN treatment, 43.5% of the patients had virological and biochemical responses. The percentage and absolute number of peripheral plasmacytoid dendritic cells decreased significantly (P less than 0.05), the number of CD3+ cells, CD4+ T cells, B cells and the ratio of CD4+/CD8+ cells decreased also (P less than 0.05), but the number of CD8+ T cells and NK cells increased (P less than 0.05).Consistent virological and biochemical responses can be seen in some patients with CHB virus infection after CIFN treatment, and the percentage and number of their peripheral plasmacytoid dendritic cells greatly decreased, but the number of CD8+ T cells and NK cells increased.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Ai-min",
                "org": "PLA 302 Hospital, Beijing 100039, China."
            },
            {
                "name": "Wang Hui-fen",
                "org": ""
            },
            {
                "name": "Ji Wei",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Yan Tao",
                "org": ""
            },
            {
                "name": "Zhang Hui",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2007
    },
    "afLT7sPX": {
        "id": "afLT7sPX",
        "title": "Hypercytolytic activity of hepatic natural killer cells correlates with liver injury in chronic hepatitis B patients.",
        "abstract": "Natural killer (NK) cells are abundant in the liver and serve as a major innate immune component against microbial infection. Although NK cells have been implicated in inducing hepatocellular damage in patients with chronic hepatitis virus infections, the roles that hepatic NK cells play in chronic hepatitis B virus (HBV) infections remain obscure. In this study, we comprehensively characterized intrahepatic and peripheral NK cells and investigated their impact on liver pathology in a cohort of HBV-infected individuals; this cohort included 51 immune-activated (IA) patients, 27 immune-tolerant (IT) carriers, and 26 healthy subjects. We found that NK cells expressing NK receptors (activation receptors) preferentially accumulated in the livers of IA patients, in which they were activated and skewed toward cytolytic activity but without a concomitant increase in interferon-\u03b3 production, in comparison with those of IT carriers and healthy subjects. Further analysis showed that the livers of IA patients, in comparison with those of IT and healthy subjects, expressed higher levels of interleukin-12 (IL-12), IL-15, and IL-18 in situ and lower levels of IL-10, which in vitro can induce the activation and degranulation of NK cells from healthy individuals. Finally, hepatic NK cells displayed more cytolytic activity than peripheral NK cells, and this was found to be positively correlated with the liver histological activity index and serum alanine aminotransferase levels in these IA patients.In IA patients, hepatic NK cells are activated and preferentially skew toward cytolytic activity, which depends on an imbalanced cytokine milieu and correlates with liver injury during chronic HBV infection.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Zheng",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China."
            },
            {
                "name": "Zhang Shuye",
                "org": ""
            },
            {
                "name": "Zou Zhengsheng",
                "org": ""
            },
            {
                "name": "Shi Jianfei",
                "org": ""
            },
            {
                "name": "Zhao Juanjuan",
                "org": ""
            },
            {
                "name": "Fan Rong",
                "org": ""
            },
            {
                "name": "Qin Enqiang",
                "org": ""
            },
            {
                "name": "Li Baosen",
                "org": ""
            },
            {
                "name": "Li Zhiwei",
                "org": ""
            },
            {
                "name": "Xu Xiangsheng",
                "org": ""
            },
            {
                "name": "Fu Junliang",
                "org": ""
            },
            {
                "name": "Zhang Jiyuan",
                "org": ""
            },
            {
                "name": "Gao Bin",
                "org": ""
            },
            {
                "name": "Tian Zhigang",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Hepatology (Baltimore, Md.)",
        "year": 2011
    },
    "PeSFyPQP": {
        "id": "PeSFyPQP",
        "title": "Increase in peripheral and liver infiltrating regulatory T cells favors development of primary hepatocellular carcinoma]",
        "abstract": "This study attempted to investigate the features of Treg cells in peripheral blood and liver of patients with primary hepatocellular carcinoma (HCC).Peripheral blood samples were obtained from 30 HCC patients and 30 healthy control subjects, then were quantitatively analyzed for Treg cells by using flow cytometry. Liver infiltrating lymphocytes (LIL) isolated from resected tumor samples of 7 HCC patients were simultaneously analyzed.There was a significant increase in the frequency of peripheral Treg cells in HCC patients compared with healthy controls (P < 0.01). Furthermore, we also found that there was a higher frequency of infiltrated Treg within tumor samples than the counterpart in non-tumor region (P < 0.05). In addition, CD4(+) CD25(low) and CD4(+) CD25(-) T cells isolated from resected tumor samples were found to express higher level of FOXP3 molecules.Our findings showed that a dramatic increasing increase of Treg in peripheral blood and liver tissue of HCC patients may be associated with the significant increased development of Treg, which favors the disease progression through the suppressive effect of Treg on host immune response in these patients.",
        "keywords": [
            "t cell",
            "pathogenic mechanism",
            "primary carcinoma of liver"
        ],
        "authors": [
            {
                "name": "Wang Si-yu",
                "org": "Research Center of Biological Therapy, No. 302 Hospital of PLA, Beijing 100039, China."
            },
            {
                "name": "Fu Jun-liang",
                "org": ""
            },
            {
                "name": "Lv Ji-yun",
                "org": ""
            },
            {
                "name": "Chen Li-ming",
                "org": ""
            },
            {
                "name": "Lv Sa",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2011
    },
    "ZpXaz8yG": {
        "id": "ZpXaz8yG",
        "title": "Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients.",
        "abstract": "Functional defects in natural killer (NK) cells have been proposed to be responsible for the failure of anti-tumor immune responses. Whether and how NK cells are impaired in hepatocellular carcinoma (HCC) patients remain unknown. In this study, we found that HCC patients displayed a dramatic reduction in peripheral CD56(dim)CD16(pos) NK subsets compared with healthy subjects. A significant reduction of CD56(dim)CD16(pos) NK subsets was also found in tumor regions compared with non-tumor regions in the livers of these HCC patients. Both these peripheral and tumor-infiltrating NK cells exhibited poorer capacity to produce IFN-gamma and kill K562 targets, which was further found to be associated with increased CD4(+)CD25(+) T regulatory cells as we previously-described in HCC patients. Addition of Tregs from HCC patients efficiently inhibited the anti-tumor ability of autologous NK cells in vitro. These findings are helpful for understanding the mechanism of NK cell-mediated anti-tumor immune responses in HCC patients.",
        "keywords": [
            "pbmcs",
            "apc",
            "hcc",
            "percp",
            "nk",
            "regulatory t cells",
            "nk cells",
            "granzyme a",
            "treg",
            "phycoerythrin",
            "lil",
            "pe",
            "tumor-infiltrating lymphocyte",
            "gra",
            "natural killer",
            "til",
            "nil",
            "granzyme b",
            "fluorescein isothiocyanate",
            "healthy control.",
            "regulatory t cell",
            "grb",
            "liver-infiltrating lymphocyte",
            "peridin chlorophyll protein",
            "liver",
            "non-tumor-infiltrating lymphocyte",
            "peripheral blood mononuclear cells",
            "hc",
            "allophycocyanin",
            "fitc",
            "hepatocellular carcinoma"
        ],
        "authors": [
            {
                "name": "Lun Cai",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Lin Zhou",
                "org": ""
            },
            {
                "name": "Haiyan Wang",
                "org": "Department of Infectious Diseases, Beijing You-An Hospital Affiliated to Capital Medical University, 100069, China"
            },
            {
                "name": "Junliang Fu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Shuye Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Min Shi",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Hui Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Yongping Yang",
                "org": "The Ninth Department of Clinic, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Hao Wu",
                "org": "Department of Infectious Diseases, Beijing You-An Hospital Affiliated to Capital Medical University, 100069, China"
            },
            {
                "name": "Po Tien",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2008
    },
    "cSIv1WOR": {
        "id": "cSIv1WOR",
        "title": "Severe dendritic cell perturbation is actively involved in the pathogenesis of acute-on-chronic hepatitis B liver failure.",
        "abstract": "Functionally impaired dendritic cells (DCs) play important roles in suppressing host immune responses and facilitating viral persistence in chronic hepatitis B virus (HBV) infection. However, little is known regarding the status of intrahepatic DCs in HBV infection.Based on availability, 11 recipient liver samples were obtained from acute-on-chronic hepatitis B liver failure (ACHBLF) patients who had undergone liver transplantation. The frequencies, phenotypes, and functions of intrahepatic DC subsets were analyzed.Both plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs) extensively infiltrated the liver of the ACHBLF patients and expressed mature phenotypes therein. In particular, activated hepatic pDCs produced interferon (IFN)-alpha, which subsequently induced interleukin (IL)-12 and IL-10 production via toll-like receptor-9 ligation in liver-infiltrating lymphocytes cultured in vitro. However, blockade of IFN-alpha production significantly reduced the cytokine production of the LILs. Further, a significantly low frequency of peripheral pDCs and highly reduced IFN-alpha production were observed in a large cohort of the ACHBLF patients, particularly in the non-survivors. Moreover, a persistently upregulated expression of hepatic IFN-alpha-associated genes was observed in the ACHBLF patients during disease progression.Activated pDCs accumulated in large numbers in the liver of the ACHBLF patients and regulated local immune responses in chronic HBV infection.",
        "keywords": [
            "pbmcs",
            "acute-on-chronic hepatitis b liver failure",
            "nc",
            "acute-on-chronic liver failure",
            "prothrombin activity",
            "myeloid dendritic cells",
            "pt",
            "hepatitis b",
            "pdc",
            "interferon-\u03b1",
            "plasmacytoid dendritic cells",
            "pta",
            "normal control",
            "alt",
            "alanine aminotransferase",
            "lils",
            "achblf",
            "hbv",
            "liver-infiltrating lymphocytes",
            "peripheral blood mononuclear cells",
            "hepatitis b virus",
            "aclf",
            "prothrombin time",
            "mdc"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Zheng-Sheng Zou",
                "org": ""
            },
            {
                "name": "Jun-Liang Fu",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Lun Cai",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Center for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Yong-Jun Liu",
                "org": "Department of Immunology, MD Anderson Cancer Center, University of Texas, Houston, USA"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Journal of hepatology",
        "year": 2008
    },
    "9P1Poi4S": {
        "id": "9P1Poi4S",
        "title": "Frequency of myeloid-derived suppressor cells in peripheral blood in patients with autoimmune hepatitis",
        "abstract": "Objective To investigate the frequency of myeloid-derived suppressor cells(MDSCs) in peripheral blood in patients with autoimmune hepatitis(AIH) and its correlation with disease progression.Methods Peripheral blood samples from 22 AIH patients and 24 healthy controls were collected.The frequency of MDSCs was analyzed using flow cytometry and its correlation with liver biochemical indicators was evaluated as well.Results The frequencies of MDSCs in non-cirrhotic AIH patients were higher than those in cirrhotic AIH patients and in healthy controls,and the differences between them were significant(P<0.05).But no difference was found between cirrhotic AIH patients and healthy controls(P>0.05).The frequencies of MDSCs in peripheral blood were positively correlated with ALT and AST in all AIH patients.Conclusions In non-cirrhotic AIH patients,the peripheral frequencies of MDSCs increase correspondingly and autoimmune responses are inhibited.However,a variety of causes lead to the decrease in the number of MDSCs in cirrhotic AIH patients,thus accelerating the progress of liver injury and liver cirrhosis.",
        "keywords": [
            "immunosuppression",
            "autoimmune",
            "regulatory",
            "liver cirrhosis",
            "T-lymphocytes",
            "hepatitis",
            "marrow"
        ],
        "authors": [
            {
                "name": "LI Hai-wen",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "XU Xiang-sheng",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "LIN Hu",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "ZENG Zhen",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "LI Yuan-yuan",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "PENG Qiong",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "LI Ying",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            },
            {
                "name": "DAI Fu",
                "org": " Department of Gastroenterology,The Third Affiliated Hospital of Anhui Medical University,Hefei,Anhui ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "V2C7QvqL": {
        "id": "V2C7QvqL",
        "title": "Clinical observation in 63 child patients with influenza A(H1N1)",
        "abstract": "Objective To investigate the epidemic features,clinical characteristics and laboratory parameters of child patients with influenza A(H1N1).Methods The data including epidemiology,clinical manifestations,laboratory parameters,treatment and prognosis in 63 child patients with influenza A(H1N1)treated in our hospital were retrospectively analyzed.Results Most of the pa-tients had a close contact with patients with influenza A(H1N1).Fever(mainly high fever),cough and sore throat were the most fre-quent clinical symptoms.The laboratory findings showed that ALT,renal function and serum potassium were normal in all the patients,and CK,LDH and \u03b1-HBDH elevated mildly in some patients.All the 63 child patients were cured and discharged from hospital.Conclusions The incidence of influenza A(H1N1) in children is related to a close contact with patients with influenza A(H1N1).Fever and other upper respiratory tract symptoms are the main clinical manifestations.The disease keeps a stable state and is self-limited.",
        "keywords": [
            "complement",
            "H1N1 subtype",
            "signs and symptoms",
            "influenza A virus",
            "retrospective studies"
        ],
        "authors": [
            {
                "name": "ZHOU Zhi-ping",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YAN Hui-ying",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "XIE Yang-xin",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "TU Bo",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "JOl3mOLZ": {
        "id": "JOl3mOLZ",
        "title": "Multivariate regression analysis of risk factors of complications of Double-J ureteral stents after ureterscopic holmium-laser lithotripsy",
        "abstract": "Objective To investigate the risk factors of the complications of double-J ureteral stents after ureterscopic holmium-laser lithotripsy.Methods Data of 257 prospective consecutive patients were studied to identify clinical and surgical factors associated with complication of double-J ureteral stents with multivariate regression analysis between March 2009 and Dec.2010.Results Of the 257 patients,83.2% developed complications after double-J ureteral stents were indwelt.Significant factors associated with urinary irritation included crossing of the lower end to the stent to the opposite side,the 26 cm stents and stent duration over 4 weeks,which was associated with dysuria.The 24 cm and 26 cm stents both correlated with flank pain.In addition,the 26 cm stents and stent duration over 4 weeks caused gross hematuria.Finally,crossing of the lower end to the stent was associated with urge incontinence.Conclusions Most complications are correlated with longer stents.Proper length of stent must be chosen to reduce the incidence of stent-related complications.",
        "keywords": [
            "multivariate analysis",
            "ureterscopic lithotripsy",
            "double-J ureteral stents",
            "risk factors"
        ],
        "authors": [
            {
                "name": "PANG Xiang",
                "org": "Department of Urology,303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "ZHOU Da-qing",
                "org": "Department of Urology,303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": "Department of Urology,303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "HE Meng",
                "org": "Department of Urology,303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "WANG Jian",
                "org": "Department of Urology,303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "YU Xiao-xiang",
                "org": "Department of Urology,303rd Hospital of PLA,Nanning ,China"
            }
        ],
        "venue": "Journal of Modern Urology",
        "year": 2012
    },
    "odW65IGo": {
        "id": "odW65IGo",
        "title": "PD-1 and PD-L1 upregulation promotes CD8+ T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients",
        "abstract": "Programmed death 1 (PD-1) and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of cytotoxic CD8+ T lymphocytes, the main effector cells in hepatocellular carcinoma (HCC) patients, are not well defined. In this study, we characterized circulating and intratumor PD-1/PD-L1 expression and analyzed their association with disease progression in a cohort of hepatitis B virus-infected patients, including 56 with HCC, 20 with liver cirrhosis (LC) and 20 healthy controls (HC). The frequency of circulating PD-1+CD8+ T cells increased with disease progression from LC to HCC patients versus HC. Furthermore, tumor-infiltrating effector CD8 + T cells showed a drastic increase in PD-1 expression. These increases in circulating and intratumor PD-1+CD8+ T cells could predict poorer disease progression and postoperative recurrence. Immunohistochemical staining showed that PD-L1 expressing hepatoma cells and apoptotic infiltrating CD8+ T cells were both enriched in tumor sections. In vitro, CD8+ T cells induced PD-L1 expression on hepatoma cells in an IFN-\u03b3-dependent manner, which in turn promoted CD8 + T cells apoptosis, and blocking PD-L1 reversed this effect. Therefore, this study extends our knowledge of the role of the PD-1/PD-L1 pathway in tumor evasion and provides evidence for a new therapeutic target in HCC patients. Copyright \u00a9 2010 UICC.",
        "keywords": [
            "apoptosis",
            "hepatocellular carcinoma",
            "PD-1",
            "PD-L1"
        ],
        "authors": [
            {
                "name": "Feng Shi",
                "org": "Institute of Microbiology Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Ming Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zhen Zeng",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ruizhao Qi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zhenwen Liu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Yongping Yang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Po Tien",
                "org": "Institute of Microbiology Chinese Academy of Sciences(Chinese Academy of Sciences),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "International Journal of Cancer",
        "year": 2011
    },
    "Sa5NfGlw": {
        "id": "Sa5NfGlw",
        "title": "Difference in the CD4+T lymphocytes activation between long term non-progressors and typical progressors of HIV-1 infected patients]",
        "abstract": "To investigate the difference in the CD4+T lymphocytes activation between long term non progressors (LTNP) and typical progressors (TP) of HIV-1 infected patients.Twenty-four HIV-1 infected patients and 15 heathy control adults were tested and flow cytometry was used to detect the activation marker CD38 and CD4 count in blood samples taken from the patients and control. bDNA method was used to test the virus load in the plasma of patients.The activation of CD4+T cells was positively correlated with virus load and negatively correlated with CD4 counts. Compared with normal controls, the activation of CD4+T cells was obviously increased in TP patients but not obviously changed in LTNP patients.Compared with healthy controls, the activation of CD4+T cells in LTNP did not obviously increase. This maybe partially accounts for LTNP patients keeping a good state for a long time.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiao Yan-mei",
                "org": "Beijing You-an Hospital Affiliated to Capital University of Medical Sciences, Beijing 100054, China."
            },
            {
                "name": "Fu Jun-liang",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Zhang Hui",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Zhou Chun-bao",
                "org": ""
            },
            {
                "name": "Fu Bao-yun",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            },
            {
                "name": "Wu Hao",
                "org": ""
            }
        ],
        "venue": "Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology",
        "year": 2007
    },
    "d8RueNeN": {
        "id": "d8RueNeN",
        "title": "Efficacy of Jiuziyijing Oral Liquid Combined with Operation in Treatment of Sergeants with Varicocele and Oligoasthenozoospermia",
        "abstract": "Objective To observe the clinical efficacy of Jiuziyijing Oral Liquid combined with operation in treatment of sergeants with varicocele and oligoasthenozoospermia.Methods A total of 408 sergeants with varicocele and oligoasthenozoospermia were divided into two groups:204 patients who visited doctors during June 2010 and August 2011( control group) and 204 patients who visited doctors during September 2011 and October 2012( experimental group).Patients in experimental group were treated with vena spermatica interna high ligation surgery through inguinal canal,while patients in control group were treated with vena spermatica interna high ligation surgery through inguinal canal and traditional Chinese medicine( Jiuziyijing Oral Liquid).The semen qualities were compared before and after treatment for 6 months.Results There was no statistical significance between the two groups in the semen quality before treatment( P >0.05).The differences of semen volume in two groups were no statistically significant before and after treatment for 6 months( P > 0.05),but the total sperm number,sperm density,grade A sperm motility,grade B sperm motility,sperm survival rate and percentage of normal morphological sperm after treatment were significantly increased,compared with those before treatment,and the differences in experimental group were significantly better than those in control group( P < 0.05).Conclusion Vena spermatica interna high ligation surgery through inguinal canal combined with Jiuziyijing Oral Liquid may improve the sperm quality of sergeants with varicocele and oligoasthenozoospermia.",
        "keywords": [
            "Vena spermatica interna high ligation",
            "Varicocele",
            "Semen",
            "Jiuziyijing oral liquid"
        ],
        "authors": [
            {
                "name": "YU Xiao-xiang",
                "org": ""
            },
            {
                "name": "ZHAO Dong-hai",
                "org": ""
            },
            {
                "name": "QU Hai-yan",
                "org": ""
            },
            {
                "name": "FANG Ru-mei",
                "org": ""
            },
            {
                "name": "YE Chang-qing",
                "org": ""
            },
            {
                "name": "ZHOU Da-qing",
                "org": ""
            },
            {
                "name": "LI Wen-gang",
                "org": ""
            },
            {
                "name": "LIU Shang-wen",
                "org": ""
            },
            {
                "name": "ZHAN Jian-ming",
                "org": ""
            },
            {
                "name": "SHAO Yong",
                "org": ""
            }
        ],
        "venue": "Medical & Pharmaceutical Journal of Chinese People's Liberation Army",
        "year": 2013
    },
    "3Lkfdzon": {
        "id": "3Lkfdzon",
        "title": "Phenotypical and functional characteristic of FoxP3(+);CD39(+); regulatory T cells in humans]",
        "abstract": "To investigate phenotypical and functional characteristics of the CD39(+);FoxP3(+);regulatory T (Treg) cells in humans.We collected peripheral blood from 10 healthy volunteers and separated PBMC by using density gradient centrifugation, and then detected the expression of CTLA-4, HLA-DR, CD45RO and Ki-67 on CD39(+);FoxP3(+); and CD39(-);FoxP3(+);Treg cells by using flow cytometric analysis. [(3);H]-thymidine incorporation assay and ELISA were used to monitor the suppressive capacity of CD39(+); FoxP3(+); Treg cells on proliferation and IFN-gamma secretion of Treg-depleted PBMC.The expression of CTLA-4, HLA-DR, CD45RO and Ki-67 was significantly higher in CD39(+);FoxP3(+); Treg cells than those in CD39(-);FoxP3(+); Treg cells. The suppressive capacity of CD39(+);FoxP3(+); Treg cells on proliferation and IFN-gamma secretion of Treg-depleted PBMC was significantly higher than those of FoxP3(+);CD39(-);Treg cells.CD39(+);Fxop3(+);Treg subset may play an essential role in immune regulation of Treg, and CD39 can be used as a surface marker to identify the functional Treg cells.",
        "keywords": [],
        "authors": [
            {
                "name": "Huang Hui-huang",
                "org": "Academy of Military Medical Science, Beijing 100850, China."
            },
            {
                "name": "Wang Si-yu",
                "org": ""
            },
            {
                "name": "Wang Hui-fen",
                "org": ""
            },
            {
                "name": "Fu Jun-liang",
                "org": ""
            },
            {
                "name": "Han Ping",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2010
    },
    "LCNfgvMz": {
        "id": "LCNfgvMz",
        "title": "Determination of insulin resistance index and its clinical significance in chronic liver disease related to hepatitis B virus",
        "abstract": "Objective To investigate the role of insulin resistance index (HOMA-IR) in premonishing hepatogenous diabetes subsequent to chronic liver disease related to hepatitis B virus. Methods Fasting plasma glucose (FPG) and fasting serum insulin (FINS) were measured in 176 patients, including 80 patients with chronic hepatitis B (CHB), 66 patients with liver cirrhosis (LC) and 30 patients with chronic severe hepatitis B (CSHB). In addition 30 healthy subjects served as control (group HC). None of the subjects in the study had a history of diabetes. FPG and FINS were measured in all the subjects to exclude impaired glucose tolerance and diabetes. Then HOMA-IR was calculated. Results Among the HC and CHB, LC and CSHB patients, both FINS and HOMA-IR levels gradually elevated. FINS and HOMA-IR in CHB patients (10.58\u00b16.48, 2.35\u00b11.55) were significantly higher than those in group HC (8.06\u00b12.14,1.68\u00b11.53), while lower than those in LC (12.73\u00b15.88, 2.91\u00b11.41) and CSHB (18.30\u00b114.17, 4.35\u00b13.17) patients (P<0.05). Among CHB patients, no significant difference in FINS and HOMA-IR was found between the patients with mild or moderate disease (P>0.05), while the values of FINS and HOMA-IR were significantly higher in severe patients than those in moderate patients (P<0.05). There was no significant difference in FPG between CHB patients and group HC and among CHB patients (P>0.05), while the values of FPG were significantly higher in LC and CSHB patients than those in group HC (P<0.05). Among the LC patients with different Child-Pugh scores, FPG in Child-C group was significantly higher than that in Child-A (P<0.01). Conclusion The insulin resistance index may be used as an important predictor of hepatogenous diabetes in the patients with chronic liver disease related to hepatitis B virus.",
        "keywords": [
            "chronic",
            "hepatitis B",
            "insulin resistence",
            "glucose tolerance test"
        ],
        "authors": [
            {
                "name": "LI Bing-yu",
                "org": ". Old Cadre Medical Section, Xiangya Hospital, Central South University, Changsha , China"
            },
            {
                "name": "WANG Fu-Sheng",
                "org": ". Old Cadre Medical Section, Xiangya Hospital, Central South University, Changsha , China"
            },
            {
                "name": "ZHANG Ji-Yuan",
                "org": ". Old Cadre Medical Section, Xiangya Hospital, Central South University, Changsha , China"
            },
            {
                "name": "LIU Hui-xia",
                "org": ". Old Cadre Medical Section, Xiangya Hospital, Central South University, Changsha , China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2009
    },
    "nizGhZD0": {
        "id": "nizGhZD0",
        "title": "Effects ofin vivo gene transduction of anti-MDR1 ribozyme in combination with chemotherapy on multidrug-resistant human lymphoma growth in mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Dong-ping Xu",
                "org": ""
            },
            {
                "name": "Fu-sheng Wang",
                "org": ""
            },
            {
                "name": "Ohnuma Takao",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            }
        ],
        "venue": "Chinese Journal of Cancer Research",
        "year": 2003
    },
    "xnL0Tymg": {
        "id": "xnL0Tymg",
        "title": "Characteristics of HIV-1-specific CD8 T-cell responses and their role in loss of viremia in children chronically infected with HIV-1 undergoing highly active antiretroviral therapy.",
        "abstract": "Few studies have examined the properties of human immunodeficiency virus type 1 (HIV-1) epitope-specific cytotoxic T lymphocyte (CTL) responses in children. To address this issue, we characterized epitope-specific CTL responses and analyzed the determinants that may affect CTL responses before and after highly active antiretroviral therapy (HAART) in children with HIV-1 infection.A total of 22 HIV-1-infected children and 23 uninfected healthy children as control were enrolled in the study. Circulating CD4 T cells and HIV-1 RNA load in plasma were routinely measured. Peripheral HIV-1-specific CTL frequency and HIV-1 epitope-specific, interferon-gamma (IFN-gamma)-producing T lymphocytes were measured using tetramer staining and enzyme-linked immunospot (ELISPOT) assay, respectively. Circulating dendritic cell (DC) subsets were monitored with FACS analysis.More than 80% of the children with HIV-1 infection exhibited a positive HIV-1-epitope-specific CTL response at baseline, but HIV-specific CTLs and IFN-gamma-producing lymphocytes decreased in patients who responded to HAART in comparison with non-responders and HAART-naive children. The duration of virus suppression resulted from HAART was inversely correlated with CTL frequency. While in HAART-naive children, HIV-1-specific CTL frequency was positively correlated with myeloid DC (mDC) frequency, although the cause and effect relationship between the DCs and CTLs remains unknown.HIV-1-epitope-specific CTL responses are dependent on antigenic stimulation. The impaired DC subsets in blood might result in a defect in DC-mediated T cell responses. These findings may provide insight into understanding the factors and related mechanisms that influence the outcome of HIV-1 carriers to HAART or future antiviral therapies.",
        "keywords": [
            "child",
            "human immunodeficiency virus",
            "dendritic cells",
            "cytotoxic t lymphocyte"
        ],
        "authors": [
            {
                "name": "Zhang Zheng",
                "org": "Research Center of Biological Therapy, PLA 302 Hospital, Beijing, China."
            },
            {
                "name": "Zhao Qing-xia",
                "org": ""
            },
            {
                "name": "Fu Jun-liang",
                "org": ""
            },
            {
                "name": "Yao Jin-xia",
                "org": ""
            },
            {
                "name": "He Yun",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Chinese medical journal",
        "year": 2006
    },
    "zZjF4ZxO": {
        "id": "zZjF4ZxO",
        "title": "Progress of immune response and immune therapy in HBV-infected patients",
        "abstract": "Increasing evidence has shown that three critical elements-the HBV virion,the host's hepatocyte and immune sys-tems-engage in a dynamic interplay that drives the progression of HBV infection.Based on the characteristics of host immune re-sponse in patients with HBV infection,a \"climbing slope hypothesis\" is proposed to suggest that therapeutic strategies aiming at mo-dulating the immune activity of the host may represent a complementary approach to antiviral drug treatment for the management of chronically HBV-infected patients.The review focuses on the progress of immune response and immune therapy in HBV-infected patients.",
        "keywords": [
            "antiviral therapy",
            "immune therapy",
            "disease progression",
            "hepatitis B virus",
            "host immunity"
        ],
        "authors": [
            {
                "name": "WANG Fu-sheng",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "1S4r3h8S": {
        "id": "1S4r3h8S",
        "title": "Compartmentalization and its implication for peripheral immunologically-competent cells to the liver in patients with HBV-related acute-on-chronic liver failure.",
        "abstract": "This study attempts to characterize the feature of immunologically competent cells (ICCs) and evaluate its clinical implication in patients with acute-on-chronic liver failure (ACLF) in relation to chronic hepatitis B virus (HBV) infection.Circulating ICCs were examined in ACLF patients (n = 75), as well as in patients with hepatitis B (CHB, n = 31), CHB-related liver cirrhosis (LC, n = 36), and normal controls (NC, n = 30). Intrahepatic ICCs in some patients were further analyzed via immunohistochemical and flow cytometric assays.Total lymphocytes, CD4(+) T cells, CD8(+) T cells, and NK cells in circulation were numerically lower in the ACLF and LC groups compared to the CHB and NC groups. Importantly, the number of these cells was significantly lower in non-surviving ACLF patients compared with surviving ACLF patients. In comparison to NC, ACLF patients displayed a significantly higher ratio of liver-infiltrating CD4(+) T-cell frequency than its circulating counterpart, suggesting that the possiblility of the ICCs compartmentalization from the peripheral blood into the liver in ACLF. Immunohistochemical analysis showed that intrahepatic CD4(+) cells, CD8(+) cells, and CD56(+) cells were significantly higher in the ACLF group compared with the other three groups, suggesting a stronger cellular immune response-mediated inflammation in ACLF group than other patient groups.The abnormal prevalence of circulating and intrahepatic ICCs possibly acts as an important factor that may drive the progression of HBV-related ACLF.",
        "keywords": [
            "acute-on-chronic liver failure",
            "immulogically competent cells",
            "immunohistochemistry",
            "liver-infiltrating lymphocytes",
            "hepatitis b virus",
            "immune response"
        ],
        "authors": [
            {
                "name": "Zhengsheng Zou",
                "org": ""
            },
            {
                "name": "Dongping Xu",
                "org": ""
            },
            {
                "name": "Baosen Li",
                "org": ""
            },
            {
                "name": "Shaojie Xin",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Lei Huang",
                "org": ""
            },
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Yongping Yang",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Jing-Min Zhao",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Guangde Zhou",
                "org": ""
            },
            {
                "name": "Yanling Sun",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Hepatology research : the official journal of the Japan Society of Hepatology",
        "year": 2009
    },
    "1wP9L9TW": {
        "id": "1wP9L9TW",
        "title": "HBcAg-pulsed dendritic cell vaccine induces Th1 polarization and production of hepatitis B virus-specific cytotoxic T lymphocytes.",
        "abstract": "Dendritic cells (DCs) pulsed with HBsAg efficiently reverse the immune tolerance to hepatitis B virus (HBV) and induce HBV-specific cytotoxic T lymphocyte (CTL) responses in transgenic mice and healthy volunteers. However, it is not clear whether HBV core antigen (HBcAg)-pulsed DCs can effectively induce CD4(+) helper T cells polarization into Th1, which contribute to the induction and maintenance of HBV-specific CD8(+) T cells in chronic hepatitis B (CHB) patients. To address this issue, we conducted this study and investigated whether HBcAg-pulsed DCs could polarize Th1 cells and induce an HBcAg-specific CTL response.HBcAg-pulsed DCs were generated from 21 CHB patients. The capacity of the HBcAg-pulsed DC vaccine to stimulate CD4(+) and CD8(+) T cells to produce IFN-gamma and IL-4 was estimated by intercellular cytokine staining, and the HBcAg-pulsed DCs derived from 10 humam leucocyte antigen (HLA)-A2(+) CHB patients were tested for the induction of HBV-specific CTLs from autologous T cells by pentamer staining. The cytotoxicity of these CTLs was evaluated in vitro by flow cytometry.The HBcAg-pulsed DCs derived from CHB patients exhibited a stronger capacity to stimulate autologous CD4(+) and CD8(+) T cells to release IFN-gamma rather than IL-4, which could induce HBV core 18-27 specific CTLs, suggesting a specific cytotoxicity against T2 cells that had been loaded with the HBV core 18-27 peptide in vitro.HBcAg-pulsed DC vaccine derived from CHB patients efficiently induced autologous T cell polarization to Th1 and generation of HBV core 18-27 specific CTLs.",
        "keywords": [
            "polarization",
            "dendritic cells",
            "hepatitis b virus",
            "chronic hepatitis b",
            "t helper cell",
            "cytotoxic t lymphocyte"
        ],
        "authors": [
            {
                "name": "Weiwei Chen",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Feng Shi",
                "org": ""
            },
            {
                "name": "Yuanli Mao",
                "org": ""
            },
            {
                "name": "Zirong Tang",
                "org": ""
            },
            {
                "name": "Bin Zhang",
                "org": ""
            },
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Liangen Chen",
                "org": ""
            },
            {
                "name": "Liming Chen",
                "org": ""
            },
            {
                "name": "Shaojie Xin",
                "org": ""
            },
            {
                "name": "Fu-sheng Wang",
                "org": ""
            }
        ],
        "venue": "Hepatology research : the official journal of the Japan Society of Hepatology",
        "year": 2009
    },
    "FAZb0ySi": {
        "id": "FAZb0ySi",
        "title": "Human mesenchymal stem cell transfusion is safe and improves liver function in acute-on-chronic liver failure patients.",
        "abstract": "Acute-on-chronic liver failure (ACLF) is a severe, life-threatening complication, and new and efficient therapeutic strategies for liver failure are urgently needed. Mesenchymal stem cell (MSC) transfusions have been shown to reverse fulminant hepatic failure in mice and to improve liver function in patients with end-stage liver diseases. We assessed the safety and initial efficacy of umbilical cord-derived MSC (UC-MSC) transfusions for ACLF patients associated with hepatitis B virus (HBV) infection. A total of 43 ACLF patients were enrolled for this open-labeled and controlled study; 24 patients were treated with UC-MSCs, and 19 patients were treated with saline as controls. UC-MSC therapy was given three times at 4-week intervals. The liver function, adverse events, and survival rates were evaluated during the 48-week or 72-week follow-up period. No significant side effects were observed during the trial. The UC-MSC transfusions significantly increased the survival rates in ACLF patients; reduced the model for end-stage liver disease scores; increased serum albumin, cholinesterase, and prothrombin activity; and increased platelet counts. Serum total bilirubin and alanine aminotransferase levels were significantly decreased after the UC-MSC transfusions. UC-MSC transfusions are safe in the clinic and may serve as a novel therapeutic approach for HBV-associated ACLF patients.",
        "keywords": [
            "cell proliferation",
            "mesenchymal stromal cells",
            "young adult",
            "liver function tests"
        ],
        "authors": [
            {
                "name": "Shi Ming",
                "org": "Research Center for Biological Therapy, Institute of Translational Hepatology, and."
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Xu Ruonan",
                "org": ""
            },
            {
                "name": "Lin Hu",
                "org": ""
            },
            {
                "name": "Fu Junliang",
                "org": ""
            },
            {
                "name": "Zou Zhengsheng",
                "org": ""
            },
            {
                "name": "Zhang Aimin",
                "org": ""
            },
            {
                "name": "Shi Jianfei",
                "org": ""
            },
            {
                "name": "Chen Liming",
                "org": ""
            },
            {
                "name": "Lv Sa",
                "org": ""
            },
            {
                "name": "He Weiping",
                "org": ""
            },
            {
                "name": "Geng Hua",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Liu Zhenwen",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Stem cells translational medicine",
        "year": 2012
    },
    "n5D5m9Yx": {
        "id": "n5D5m9Yx",
        "title": "Clinical significance of PD-1 expression in peripheral blood in patients with HBV related liver failure",
        "abstract": "Objective Programmed death-1(PD-1) up-regulation can impair virus-specific CDS T-cell responses during chronic viral infection.The correlation between PD-1 expression and liver failure in HBV infection,however, remain largely undefined.This study aimed at characterizing the PD-1 expression during liver failure,and further addressing how PD-1 regulates liver injury in HBV infection.Methods HBV-specific CDS T cells in peripheral blood from 16 patients with liver failure and 15 AHB patients were quantitatively analyzed and PD-1 expression in HBV-specific CDS T cells were measured by using flow cytometry.The correlation between PD-1 expression and function liver and serum HBV DNA load was performed for analyses of the impact of PD-1 expression.Results Compared with acute HBV infection PD-1 expression in HBV-specific CDS T cells was significantly down-regulated in the early phase of liver failure.PD-1 expression was further found to be positively correlated with ALT levels but not HBV load in the early phase of liver failure.During the follow-up period,compared with AHB patients who displayed a gradual decline of PD-1 with the recovery of disease,PD-1 up-regulation was found to be delayed.Conclusion Compared with acute HBV infection,PD-1 expression in HBV-specific CDS T cells was significantly down-regulated in the early phase of liver failure while the delayed PD-1 up-regulation was closely correlated with the occurrence of liver failure.PD-1/PD-L1 pathway, therefore,may play a key role in the pathogenesis of liver failure.",
        "keywords": [
            "PD-1",
            "Liver failure",
            "Hepatitis B virus"
        ],
        "authors": [
            {
                "name": "TENG Guang-ju",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "ZHANG Zheng",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "SUN Ying",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "CHANG Bin-xia",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "ZHANG Wei",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "ZHAO Jun",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "TIAN Hui",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "ZOU Zhengsheng",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "LI Bao-sen",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ".Non-infectious Liver Disease Center,302 Hospital of PLA,Beijing . China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2012
    },
    "WAM9Sv0P": {
        "id": "WAM9Sv0P",
        "title": "Clinial study on external electric heat theropy with shortwave plus the theropy of enema with Chinese herbs on chronic pelvic inflammation",
        "abstract": "Objective To discuss clinical effects of external electric heat theropy with shortwave plus the theropy of enema with Chinese herbs on patients with chronic pelvic inflammation.Methods Ninety cases with chronic pelvic inflammation were divided into 3 groups: control group 1 with Chinese herbs,control group 2 treated by external electric heat treatment with shortwave and treatment group by external electric heat theropy with shortwave plus the theropy of enema with Chinese herbs(30 cases in each).The clinical effects in each g roup were evaluated by clinical examination and results of B ultrasound.Results The effective rate in treatment group was higher than that in control group 1 and group 2,the extinctive rate of pelvic inflammatory mass in treatment group was significantly higher than that in control groups(P < 0.05).There was no obvious toxic and side effects.Conclusions Effects of external electric heat theropy with shortwave plus the theropy of enema with Chinese herbs on chronic pelvic inflammation is significant and this theropy is worthy of doing futher reseaches.",
        "keywords": [
            "Chronic pelvic inflammatory",
            "Enema with chinese herbs",
            "External electric heat theropy with shortwave"
        ],
        "authors": [
            {
                "name": "PAN Xiao-qing",
                "org": ".303 Hospital of People\u2032s Liberation Army,Nanning ,China"
            },
            {
                "name": "HE Yan-fang",
                "org": ".303 Hospital of People\u2032s Liberation Army,Nanning ,China"
            },
            {
                "name": "WANG Jian",
                "org": ".303 Hospital of People\u2032s Liberation Army,Nanning ,China"
            },
            {
                "name": "ZHOU Da-qing",
                "org": ".303 Hospital of People\u2032s Liberation Army,Nanning ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": ".303 Hospital of People\u2032s Liberation Army,Nanning ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2011
    },
    "rprkuoYh": {
        "id": "rprkuoYh",
        "title": "Expression profile of OX40L on peripheral blood monocytes in patients with chronic hepatitis C",
        "abstract": "Objective To investigate the expression profile of OX40L in patients with chronic hepatitis C(CHC) and its clinical significance.Methods Peripheral blood samples from 35 CHC patients and 30 healthy controls(HC) were collected.The frequency of OX40L-positive monocytes was analyzed using flow cytometry and its correlation with liver biochemical indicators was evaluated as well.Results OX40L expression was significantly up-regulated on circulating monocytes in CHC patients compared with HC.The OX40L up-regulation was correlated with an elevation of serum alanine aminotransaminase and HCV RNA.In addition,both HCV Core and NS3 antigens could strongly promote expression of OX40L on monocytes.Conclusions OX40L is up-regulated preferen-tially on monocytes in CHC patients and the up-regulated expression of OX40L on circulating monocytes may act as a potential indicator for liver inflammation,which might facilitate the diagnosis of CHC patients.",
        "keywords": [
            "OX40L-OX40",
            "hepatitis C virus",
            "monocytes",
            "hepatitis"
        ],
        "authors": [
            {
                "name": "WANG Yu",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "LIN Hu",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            },
            {
                "name": "LIAO Ming",
                "org": " College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "tx9fRnRi": {
        "id": "tx9fRnRi",
        "title": "Transurethral plasmakinetic enucleation of prostate and suprapubic small cut in the treatment of high risk and senior patient with benign prostatic hyperplasia and bladder stones]",
        "abstract": "To explore the safety and efficiency of transurethral plasmakinetic enucleation of prostate (TUPKEP) and suprapubic small cut in the treatment of high-risk and senior patients with benign prostatic hyperplasia and bladder stones.A retrospective review was conducted for 68 high-risk and senior patients with benign prostatic hyperplasia and bladder stones. All of them were treated by TUPKEP and suprapubic small cut.Operation was successfully performed in all 68 cases. And there was no instance of transurethral resection syndrome, shock, myocardial infarct, cerebral infarction, cerebral hemorrhage, permanent urinary incontinence or surgical site infection. Seven patients with temporal urinary incontinence recovered at a mean time of (9.48 \u00b1 1.52) days post-operation. The mean operative duration was (48.63 \u00b1 4.14) min and the mean volume of blood loss (50.97 \u00b1 5.33) ml. The changes of maximum flow rate (Qmax), international prostatic symptom score (I-PSS) and quality-of-life (QOL) were statistically significant before and after operation. Qmax increased from (4.56 \u00b1 0.35) to (18.82 \u00b1 1.65) ml/s (P < 0.001), I-PSS decreased form (21.96 \u00b1 1.89) to (11.23 \u00b1 0.86) (P = 0.018) and QOL decreased from (4.94 \u00b1 0.35) to (1.95 \u00b1 0.32) (P = 0.011).The approach of TUPKEP and suprapubic small cut is both safe and effective in the treatment of high-risk and senior patient with benign prostatic hyperplasia and bladder stones and should be widely applied.",
        "keywords": [
            "prostatic hyperplasia",
            "surgery",
            "therapy",
            "urinary bladder calculi"
        ],
        "authors": [
            {
                "name": "Yu Xiao-xiang",
                "org": "Department of Urology, No. 303 Hospital of PLA, Nanning 530021, China."
            },
            {
                "name": "Zhang Rui-ming",
                "org": ""
            },
            {
                "name": "Zhou Da-qing",
                "org": ""
            },
            {
                "name": "Mo Zeng-nan",
                "org": ""
            },
            {
                "name": "Li Wen-gang",
                "org": ""
            },
            {
                "name": "Wang Qiang",
                "org": ""
            },
            {
                "name": "Wang Jian",
                "org": ""
            },
            {
                "name": "Jiang Bo",
                "org": ""
            },
            {
                "name": "Deng Cheng-hui",
                "org": ""
            },
            {
                "name": "Pang Xiang",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2013
    },
    "v2QftpNx": {
        "id": "v2QftpNx",
        "title": "Investigation of FoxP3 expression in peripheral blood and liver tissue of patients with hepatitis B",
        "abstract": "Objective To investigate forkhead/winged helix transcription factor (FoxP3) expression in peripheral blood and liver-infiltrating lymphocytes (LIL) of patients with hepatitis B. Methods Flow cytometry, immunohistochemistry and real-time RT-PCR were employed for Fox P3 analysis of blood or live tissue obtained from patients with acute hepatitis B (AHB), chronic hepatitis B (CHB) and chronic severe hepatitis B (CSHB), as well as health controls. Results Fox P3 mRNA and protein expressions were specifically identified in CD4+CD25+ regulatory T cells. The level of Fox P3 mRNA in CD4+ T cells was identical with that in CD4+CD25+ regulatory T cell in peripheral blood. In CSHB patients a significant increase of Fox P3 mRNA expression was found in peripheral blood. The mean relative FoxP3 mRNA levels of CD4+ T cells in CSHB patients, AHB patients, CHB patients, and healthy controls were 0.199\u00b10.174, 0.053\u00b10.017, 0.059\u00b10.053, and 0.056\u00b10.021, respectively (CSHB group vs. other groups, P all <0.05). In addition, in CSHB patients there was a dramatic increase in infiltration of CD8+, CD4+ and Fox P3+ LIL compared with healthy controls (patients vs. healthy controls, 90.2\u00b131.1 vs. 13.7\u00b15.1/hpf for CD8+ LIL; 75.7\u00b118.5 vs. 17.1\u00b112.8/hpf for CD4+ LIL; and 32.4\u00b113.5 vs. 0.6\u00b10.5/lpf for Fox P3+ LIL; P all <0.01). In CHB patients there was a medium increased infiltration of CD8+LIL (29.1\u00b117.7/hpf), CD4+ LIL (33.5\u00b114.3/hpf), and Fox P3+ LIL (6.0, 10.0\u00b18.6/lpf) compared with healthy controls (P all<0.05), but the quantities were significantly lower compared with CSHB patients (P all <0.01). Conclusion Fox P3 expression is associated with disease progression in chronic hepatitis B. Increase in infiltration of Fox P3+ cells in the liver may be involved in the mechanism of modulation of hyper-inflammatory reaction.",
        "keywords": [
            "regulatory T cells",
            "FoxP3",
            "immunoregulation",
            "hepatitis B"
        ],
        "authors": [
            {
                "name": "Xu Dongping",
                "org": " et al. Institute of Infectious Diseases, 302 Hospital of PLA,  Beijing, China"
            },
            {
                "name": "Fu Junliang",
                "org": " et al. Institute of Infectious Diseases, 302 Hospital of PLA,  Beijing, China"
            },
            {
                "name": "Wang Fusheng",
                "org": " et al. Institute of Infectious Diseases, 302 Hospital of PLA,  Beijing, China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2006
    },
    "83RRVLWL": {
        "id": "83RRVLWL",
        "title": "Interleukin-21 mediates hepatitis B virus-associated liver cirrhosis by activating hepatic stellate cells: Interleukin-21 mediates liver cirrhosis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "fusheng wang",
                "org": ""
            },
            {
                "name": "xiangsheng xu",
                "org": ""
            },
            {
                "name": "sa lv",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "xi yu",
                "org": ""
            },
            {
                "name": "q zeng",
                "org": ""
            },
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "guohua feng",
                "org": ""
            }
        ],
        "venue": "Hepatology Research",
        "year": 2013
    },
    "EoHji6yv": {
        "id": "EoHji6yv",
        "title": "A 48-week antiviral efficacy of combination therapy of Shuanghu Qinggan Keli and entecavir tablets on HBeAg-positive patients with chronic hepatitis B",
        "abstract": "Objective To investigate the effect of combination therapy of Shuanghu Qinggan Keli and entecavir tablets on HBeAg-positive patients with chronic hepatitis B (CHB). Methods Totally 120 HBeAg-positive CHB patients were randomized into a treatment group and a control group, with 60 patients in each group. The treatment group was given entecavir tablets and Shuanghu Qinggan Keli, and the control group was administered with entecavir tablets. After 48 weeks of treatment, ALT normalization rates, HBeAg negative and seroconversion rates, HBV DNA levels and improvement of main signs and symptoms of the two groups were compared. Results ALT normalization rates, HBeAg negative and seroconversion rates and improvement of main signs and symptoms in the treatment group were superior to those in the control group. Conclusions Combination therapy of Shuanghu Qinggan Keli and entecavir tablets achieves good effects in recovering liver function, promoting HBeAg negative conversion and se-roconversion, and improving main signs and symptoms in HBeAg-positive CHB patients.",
        "keywords": [
            "hepatitis B e antigens",
            "antiviral agents",
            "integrated traditional Chinese medicine and western medicine",
            "chronic",
            "hepatitis B"
        ],
        "authors": [
            {
                "name": "LI Feng-yi",
                "org": " * Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing , China"
            },
            {
                "name": "ZHAO Min",
                "org": " * Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing , China"
            },
            {
                "name": "LI Wen-gang",
                "org": " * Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing , China"
            },
            {
                "name": "TU Bo",
                "org": " * Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing , China"
            },
            {
                "name": "ZHANG Xin",
                "org": " * Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing , China"
            },
            {
                "name": "NIE Wei-min",
                "org": " * Treatment and Research Center for Infectious Diseases, 302 Hospital of PLA, Beijing , China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2012
    },
    "49Scd1g6": {
        "id": "49Scd1g6",
        "title": "Epidemic situation of arthropod-borne infectious diseases",
        "abstract": "Arthropod-borne infectious diseases have increasingly threatened human health,and they have approximately accounted for three fourth of emerging infectious diseases in recent years.Environmental change and natural disasters may exacerbate the prevalence of arthropod-borne infectious diseases.Controlling and eliminating insect vectors are important preventive measures.This review focuses on the category,epidemic trends,prevention and control measures of arthropod-borne infectious diseases and the prevalence of emerging arthropod-borne infectious diseases in China.",
        "keywords": [
            "communicable diseases",
            "arboviruses",
            "epidemiologic studies"
        ],
        "authors": [
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "jVxPr1dL": {
        "id": "jVxPr1dL",
        "title": "Immunopathogenesis and prognostic immune markers of chronic hepatitis B virus infection: Immunopathogenesis of hepatitis B",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "lifeng wang",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Journal of Gastroenterology and Hepatology",
        "year": 2012
    },
    "KvwVyjyw": {
        "id": "KvwVyjyw",
        "title": "Epidemiologic and Clinical Characteristics of 400 Patients with H1N1 Influenza A in Beijing",
        "abstract": "Objective To investigate the clinical and epidemiologic characteristics of pandemic influenza A(H1N1) virus infection in Beijing.Methods The epidemiological information and clinical characteristics of 400 patients with pandemic influenza A(H1N1) virus infection hospitalized in Beijing 302 Hospital from May to December,2009 were analyzed retrospectively by descriptive epidemiology.One-way ANOVA was used to assess the results.Results H1N1 virus infection preferentially affected adolescents and young adults.The mean age of the patients was 23 years.A total of 189(47.0%) of the patients had an identifiable epidemiologic link to another confirmed patient.The most common symptoms were fever(98.8%),cough(85.8%) and sore throat(58.5%).The main physical signs were pharyngeal portion congestion(94.0%) and antiadoncus(49.5%).The number of leukocytes in the peripheral blood was normal or low.The decreased serum iron and elevated C-reaction protein were found in 82.3% and 72.6% of the patients.There was significant difference in the duration of fever and viral shedding from throat swabs among the patients who accept the antiviral medication within the different time.Conclusions H1N1 virus infection preferentially affects adolescents and young adults,and presents with influenza-like illness.The clinical course of H1N1 virus infection is generally mild.The change of C-reaction protein and serum iron may be favorable for the diagnosis of H1N1.Early antiviral treatment may shorten the duration of fever and viral shedding.",
        "keywords": [
            "C-reaction protein",
            "H1N1 influenza A virus",
            "Serum iron",
            "Oseltamivir"
        ],
        "authors": [
            {
                "name": "XIE Yang-xin",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "JIANG Tian-jun",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "NIE Wei-min",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "FAN Rong",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "Zhang Xin",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "YAN Hui-Ying",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "QIU Bo",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "ZHOU Zhi-ping",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            },
            {
                "name": "ZHAO Min",
                "org": " Department of Infectious Diseases,Beijing 302 Hospital,Beijing ,P.R.China"
            }
        ],
        "venue": "West China Medical Journal",
        "year": 2011
    },
    "YdTuOYwL": {
        "id": "YdTuOYwL",
        "title": "Phenotypical and functional characteristic of FoxP3~+ CD39~+ regulatory T cells in Humans",
        "abstract": "AIM:To investigate phenotypical and functional characteristics of the CD39+FoxP3+regulatory T (Treg) cells in humans. METHODS: We collected peripheral blood from 10 healthy volunteers and separated PBMC by using density gradient centrifugation, and then detected the expression of CTLA-4, HLA-DR, CD45RO and Ki-67 on CD39+FoxP3+ and CD39-FoxP3+Treg cells by using flow cytometric analysis. [3H]-thymidine incorporation assay and ELISA were used to monitor the suppressive capacity of CD39+ FoxP3+ Treg cells on proliferation and IFN-\u03b3 secretion of Treg-depleted PBMC. RESULTS: The expression of CTLA-4, HLA-DR, CD45RO and Ki-67 was significantly higher in CD39+FoxP3+ Treg cells than those in CD39-FoxP3+ Treg cells. The suppressive capacity of CD39+FoxP3+ Treg cells on proliferation and IFN-\u03b3 secretion of Treg-depleted PBMC was significantly higher than those of FoxP3+CD39-Treg cells. CONCLUSION: CD39+Fxop3+Treg subset may play an essential role in immune regulation of Treg, and CD39 can be used as a surface marker to identify the functional Treg cells.",
        "keywords": [
            "CD39",
            "Treg cells",
            "FoxP3"
        ],
        "authors": [
            {
                "name": "HUANG Hui-huang",
                "org": ", 21Academy of Military Medical Science, Beijing "
            },
            {
                "name": "WANG Si-yu",
                "org": "302 Hospital, Beijing , China"
            },
            {
                "name": "WANG Hui-fen",
                "org": "302 Hospital, Beijing , China"
            },
            {
                "name": "FU Jun-liang",
                "org": "302 Hospital, Beijing , China"
            },
            {
                "name": "HAN Ping",
                "org": "302 Hospital, Beijing , China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ", 21Academy of Military Medical Science, Beijing "
            }
        ],
        "venue": "Chinese Journal of Cellular and Molecular Immunology",
        "year": 2010
    },
    "VqL0zDjV": {
        "id": "VqL0zDjV",
        "title": "Treatment of early-stage hepatocellular carcinoma with argon-helium cryosurgical ablation system",
        "abstract": "Objective To evaluate the clinical effect of argon-helium cryosurgical ablation system to treat early-stage hepatocellular carcinoma.Methods Totally 48 early-stage hepatocellular carcinoma patients were treated.Clinical symptom,tumor size,AFP,complications and survival time were analysised.Results At the end of the study,23 patients survived and 25 patients died.Survival time was(33.91\u00b11.39)month,survival rates of 1,2,3,4 year were 81.3%,62.1%,47.6% and 44.4%,respectively.Conclusion To early-stage hepatocellular carcinoma patients with severe liver cirrhosis,argon-helium cryosurgical ablation therapy is a ideal alternative with the advantage of few complications and good outcome.",
        "keywords": [
            "Early-stage",
            "Primary hepatocellular carcinoma",
            "Survival time",
            "Cryosurgery"
        ],
        "authors": [
            {
                "name": "ZHOU Lin",
                "org": "PLA Postgraduate Medical School,Beijing ;PLA 302 Hospital"
            },
            {
                "name": "YANG Yongping",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "LIU Jing",
                "org": "Navy General Hospital,China"
            },
            {
                "name": "FENG Yongyi",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "LU Yinying",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "WANG Chunping",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "WANG Xinzhen",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "AN Linjing",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "ZHANG Xin",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "HAO Liyan",
                "org": "PLA 302 Hospital"
            },
            {
                "name": "WANG Fusheng",
                "org": "PLA 302 Hospital"
            }
        ],
        "venue": "Chinese Journal of Gastroenterology and Hepatology",
        "year": 2008
    },
    "LB44BFRH": {
        "id": "LB44BFRH",
        "title": "Therapeutic effect of autologous cytokine-induced killer cells on patients with liver cirrhosis caused by HBV infection]",
        "abstract": "To observe the therapeutic effect of autologous cytokine-induced killer cells (CIK) on HBV DNA positive patients with liver cirrhosis.HBV DNA positive 33 patients with cirrhosis were treated with CIK. Before and after cultured in vitro and post-treatment, CD3+, CD3+CD4+, CD3+CD8+, CD3+CD56+ cells, mDC and pDC were detected by flow cytometry. The indexes of virus and liver function were compared between pre- and post-treatment.CD3+, CD3+CD8+ cells and CD3+CD56+ cells were higher after cultured in vitro and after transfused back than those before culture (91.5 +/- 10.3, 74.4 +/- 9.9 vs. 67.9 +/- 12.8; 60.9 +/- 15.5, 37.3 +/- 15.1 vs. 27.9 +/- 10.9; 18.4 +/- 11.7, 14.5 +/- 7.5 vs. 10.6 +/- 7.1). The percentages of mDC and pDC also increased after-treatment vs. pre-treatment (0.54 +/- 0.18 vs. 0.70 +/- 0.29; 0.26 +/- 0.13 vs. 0.41 +/- 0.25). HBV DNA became undetectable in 12 patients and decrease exceeded 100 times in 4 patients after treatment. HBeAg became undetectable in 10 of 14 patients who were HBeAg positive pretreatment patients, among them 2 patients had HBeAb sero conversion. The liver function was improved after treatment. All patients tolerated the treatment.CIK treatment can increase immune effector cells and has some antiviral effect and is safe.",
        "keywords": [],
        "authors": [
            {
                "name": "Su Hai-bin",
                "org": "The No. 302 Hospital of the People's Liberation Army, Beijing 100039, China."
            },
            {
                "name": "Li Han-wei",
                "org": ""
            },
            {
                "name": "Zhao Hong-lan",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Zhang Bing",
                "org": ""
            },
            {
                "name": "Tang Zi-rong",
                "org": ""
            },
            {
                "name": "Lei Zhou-yun",
                "org": ""
            },
            {
                "name": "Wang Hui-fen",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology",
        "year": 2007
    },
    "GMXUytMk": {
        "id": "GMXUytMk",
        "title": "Identification of circulating plasmacytoid dendritic cells in chronic HBV-infected patients]",
        "abstract": "To investigate the features of circulating plasmacytoid dendritic cells (pDCs) in patients with chronic hepatitis B for a better understanding of the immunopathogenesis of HBV infection.Fresh blood samples were collected from 20 patients with chronic hepatitis B (CHB) and from 15 healthy individuals who served as controls. pDCs were isolated from peripheral blood mononuclear cells (PBMCs) using immunomagnetic assay and detected by flow cytometry. Fresh PBMCs and isolated pDCs were stimulated in vitro using CpG ODN2216. The supernatants were measured for IFNa production using ELISA.The peripheral pDCs frequency in CHB patients (0.192%+/-0.110%) was markedly lower than that in the healthy controls (0.287%+/-0.142%). After being pulsed with CpG ODN2216, the isolated pDCs produced lower levels of IFNa and expressed lower levels of CD80 and CD40 in the CHB patients when compared to those of the healthy controls. The level of IFNa was (972.6+/-705.5) pg/ml in the patients and (3 142.9+/-1 292.2) pg/ml in the controls. Moreover, the pDCs frequency was reversely correlated with serum ALT levels in these HBV infected patients.The reduced number and impaired function of circulating pDCs in patients with CHB may be related to their disease progression.",
        "keywords": [
            "interferon-alpha",
            "dendritic cells",
            "hepatitis b virus"
        ],
        "authors": [
            {
                "name": "LIU Qing-feng",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "YAO Jin-xia",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "SHI Ming",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "MAO Yuan-li",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " ~*Academy of Military Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2006
    },
    "1DJLJzKG": {
        "id": "1DJLJzKG",
        "title": "Phenotype and function of myeloid dendritic cells pulsed with hepatitis B virus antigens in patients with HBV-associated hepatocellular carcinoma]",
        "abstract": "To investigate the characteristics of phenotype and function of myeloid dendritic cells (mDCs) pulsed with HBV antigens derived from HBV-associated hepatocellular carcinoma (HCC) patients.Peripheral blood mononuclear cells (PBMCs) were collected, using blood cell separator, from 21 primary HCC patients and 4 healthy donors. mDCs were propagated in serum-free AIM-V medium in the presence of cytokine cocktail, and pulsed with HBcAg or HBsAg. After 9 days' incubation, the phenotypic patterns of mDC were characterized by flow cytometry and the levels of IL-10 and IL-12 produced by mDCs were analyzed by ELISA. Autologous T cells proliferation stimulated by mDC was tested by non-radioactive cell proliferation assay kit.The expression rates of CD80, CD86, CD40, and HLA-DR in the mDCs pulsed with HBcAg were 55% +/- 26%, 80% +/- 13%, 70% +/- 13% and 73% +/- 24% respectively, significantly higher than those of the control group (29% +/- 25%, 35% +/- 18%, 44% +/- 26% and 45% +/- 23% respectively, all P < 0.05). Among the expression rates of surface molecules of the mDCs pulsed with HBsAg only the expression rate of HLA-DR was significantly higher than that of the un-pulsed mDCs (63% +/- 15% vs 45% +/- 23%, P < 0.05). T cell proliferation assay revealed an impaired allostimulatory capacity of mDCs in HCC and the stimulatory capacity of the mDCs pulsed with HBcAg to induce proliferation of autologous T cells was more powerful than that pulsed with HBsAg (P < 0.05). The levels of IL-10 and IL-12 produced by the mDCs pulsed with HBsAg were (35 pg/ml +/- 9 pg/ml and 135 pg/ml +/- 63 pg/ml respectively, both significantly lower than those pulsed with HBcAg (236 pg/ml +/- 95 pg/ml and 733 pg/ml +/- 212 pg/ml respectively, both P < 0.05).Pulsation of mDCs in vitro by HBcAg or HBsAg enhance the expression of CD80, CD86, CD40, and HLA-DR, and increase the ability of mDCs to stimulate the proliferation of autologous T lymphocytes.",
        "keywords": [
            "dendritic cells",
            "hepatitis b virus",
            "liver neoplasms"
        ],
        "authors": [
            {
                "name": "Qian Shen",
                "org": "Research Center of Biological Therapy, Hospital No. 302 of Chinese People's Liberation Army, Beijing 100039, China."
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Zhang Hui",
                "org": ""
            },
            {
                "name": "Zhang Bing",
                "org": ""
            },
            {
                "name": "Xu Dong-ping",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2005
    },
    "IaQum81H": {
        "id": "IaQum81H",
        "title": "Clinical significance of CD3~+ T lymphocyte-monocyte ratio in patients with acute-on-chronic liver failure",
        "abstract": "Objective To investigate the features of CD3+ T lymphocyte-monocyte ratio(TMR) in patients with acute-on-chronic liver failure(ACLF).Methods Fifty-five HBV-related ACLF patients,30 patients with chronic hepatitis B(CHB),and 30 healthy controls(HC) were included in the study.The number of CD3+ T lymphocytes and monocytes in peripheral blood and liver and TMR were measured by automatic blood cell counter and flow cytometry.Data were statistically analyzed using SPSS 17.0.Results CD3+ T lymphocytes decreased and monocytes increased in ACLF patients.TMR was significantly lower in ACLF patients than in CHB patients and HC(P<0.001).TMR of ACLF patients in the intermediate and late stage was lower than that of ACLF patients in the early stage(P<0.001).The following-up showed that increased TMR was observed in ACLF patients with a good prognosis,but consistent low level of TMR in the patients with a poor outcome.In vitro study indicated that the up-regulated programmed death-1 expression on T lymphocytes was closely associated with CD4+ and CD8+ T lymphocyte apoptosis.Conclusions TMR is closely associated with the disease progression of ACLF patients.It provides a new theoretical basis for the study on the pathogenesis of ACLF.",
        "keywords": [
            "liver failure",
            "lymphocytes",
            "monocytes"
        ],
        "authors": [
            {
                "name": "GENG Hua",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CHEN Li-ming",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "bKPsJJGL": {
        "id": "bKPsJJGL",
        "title": "Epidemiological and clinical features of 217 measles patients in Xinjiang during 2007\u20142008",
        "abstract": "Objective To analyze the epidemiological and clinical features of 217 measles patients treated in our hospital during 2007\u20142008 so as to provide the evidence for the diagnosis,treatment,prevention and control of measles.Methods The age and the time of the onset of measles,clinical features,complications,and diagnosis were analyzed in 217 measles patients.Results Measles occurred from November to March the next year in 88.9% of the patients.The peak age of the onset of measles was below1 year old(50.7%)and 17-40 years old(27.6%).Of 217 cases,172(79.3%) had contacted with measles patients and 91(41.9%) had been vaccinated.Fever was observedin 201 cases(92.7%),with a medium and high temperature,and bad cough in adult patients.Catarrh symptoms were common in children.The clinical process of 48 patients(22.1%) appeared to be atypical.Blood counts were mostly normal or decreased,and the cardiac muscle zymogram and liver zymogram mostly increased.Conclusions The age of the onset of measles is younger or older than before.The number of atypical cases has increased.The complications,especially the cardiac damage and hepatic lesion are common in infants.Therefore,vaccination should be strengthened in the high-risk groups,and should be enforced according to the epidemiological situation.",
        "keywords": [
            "vaccines",
            "measles",
            "signs and symptoms",
            "epidemiology"
        ],
        "authors": [
            {
                "name": "SUN Li-ru",
                "org": " Department of Infectious Diseases,23rd Hospital of PLA,Urumqi ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Department of Infectious Diseases,23rd Hospital of PLA,Urumqi ,China"
            },
            {
                "name": "HE Yan-mei",
                "org": " Department of Infectious Diseases,23rd Hospital of PLA,Urumqi ,China"
            },
            {
                "name": "XIA Jing",
                "org": " Department of Infectious Diseases,23rd Hospital of PLA,Urumqi ,China"
            },
            {
                "name": "ZHENG Yan",
                "org": " Department of Infectious Diseases,23rd Hospital of PLA,Urumqi ,China"
            },
            {
                "name": "CAI Na",
                "org": " Department of Infectious Diseases,23rd Hospital of PLA,Urumqi ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2010
    },
    "Z23OJxoj": {
        "id": "Z23OJxoj",
        "title": "Immunologically-competent cells in liver infiltrating lymphocytes in patients with chronic severe hepatitis B]",
        "abstract": "To investigate the frequencies of immunologically competent cells (ICCs) in the liver-infiltrating lymphocytes (LILs) and peripheral blood and their possible role in pathogenesis in patients with chronic severe hepatitis B (CSHB).LILs were isolated from the liver tissue samples from 11 CSHB patients and 5 normal controls (NCs) by the method of combined grinding with semi-frosted microscopic slides and sedimentation of hepatic cells. The frequency of isolated ICCs, including CD3(+), CD4(+), and CD8(+) T-cells, NK cells, NKT cells, and B cells was examined and compared with that of the circulating ICCs in the CSHB patients. Comparison was conducted between the CSHB patients and the controls.(1) In the CSHB patients, the frequencies of CD4(+) T cells and B cells in LILs were 17% +/- 6% and 3.0% +/- 1.0% respectively, both significantly lower than those in the circulating blood (32% +/- 8% and 21.4% +/- 12.2% respectively, both P < 0.01); however, the frequencies of CD8(+) T cells, NK cells, and NKT cells in LILs were 38% +/- 13%, 34% +/- 18%, and 10% +/- 4% respectively, all significantly lower than those in the circulating blood (26% +/- 6%, 15% +/- 9%, and 6% +/- 4%, all P < 0.05). (2) The frequencies of infiltrating CD3(+) T cells and CD4(+) T cells of the CSHB patients were both significantly higher than those of the NCs (P = 0.042 and P = 0.001); and the frequency of infiltrating CD8(+) T cells of the CSHB patients was higher than that of the NCs, and the and the frequencies of infiltrating NK cells and NKT cells in LILs were lower than those of the NCs, however, not significantly. (3) Compared with the liver tissues from the NCs, the liver tissues from the CSHB patients exhibited a significantly higher ratio of liver-infiltrating CD4(+) T cells to peripheral blood CD4(+) T-cell subsets (P = 0.001), and significantly lower ratios of liver-infiltrating NKT cells and B cells to the peripheral blood NKT-cells and B cells (P = 0.029 and P = 0.001 respectively).The abundant infiltrating immune active cells, especially the CD4(+) T cells, CD8(+) T cells, and NK cells, may be the causal factors that drive the progressive development of CSHB.",
        "keywords": [
            "chronic",
            "immunocompetence",
            "hepatitis b",
            "lymphocytes"
        ],
        "authors": [
            {
                "name": "ZOU Zheng-sheng",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "XU Dong-ping",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "LI Bao-sen",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "HUANG Lei",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "JIN Lei",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "LIU Qing-feng",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "XIN Shao-jie",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " No.4 Department of Infectious Diseases,Hospital No 302 of Chinese People's Liberation Army,Beijing ,China"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2007
    },
    "MpQvEGfw": {
        "id": "MpQvEGfw",
        "title": "The phenotype and function of CD4+ CD25+ regulatory T cells in hepatitis B patients]",
        "abstract": "Our aim was to investigate the frequency, phenotype and function of CD4+ CD25 high regulatory T cells (Treg) in patients with acute and chronic hepatitis B (AHB, CHB).Peripheral blood mononuclear cells (PBMCs) from 16 AHB patients at acute phase (week 1 of illness), 72 CHB patients, and 32 health subjects were analyzed for Treg frequency and CD45RO, CD45RA, CD95 and HLA-DR phenotype by flow cytometry. Intracellular expression of cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) was examined by intracellular cytokines staining. Forkhead/winged helix transcription factor (FoxP3) mRNA was detected by a real-time RT-PCR assay. The effects of MACS magnetic beads-purified Treg cells on the proliferation of PBMCs were examined by a [3H]-thymidine incorporation assay. The effect of Treg cells on IFN gamma secretion of autologous PBMCs was examined by ELISA.CHB patients presented a higher fraction of circulating CD4+ CD25 high Treg frequency than AHB patients (P < 0.05), but had no significant difference compared with healthy controls. CD4+ CD25 high Treg expressed high levels of CD45RO, HLA-DR and CTLA-4, low level of CD45RA, and expressed FoxP3 mRNA specifically. We also observed that Treg cells could suppress the expansion and IFN gamma secretion of autologous PBMCs when stimulated with HBV antigen or anti-CD3 antibody, and the suppressive effect was stronger when HBV antigen was used as stimulator.CHB patients presented a higher fraction of circulating Treg frequency than AHB patients at acute phase, but had no significant difference compared with healthy controls. FoxP3 mRNA was specifically expressed in CD4+ CD25+ cell population. Treg could suppress HBV antigen-specific T cell response in vitro. The study furthers our understanding of Treg's role in immunopathogenesis of hepatitis B.",
        "keywords": [],
        "authors": [
            {
                "name": "Fu Jun-liang",
                "org": "Research Center of Biological Therapy, the 302th Hospital of PLA, Beijing 100039, China."
            },
            {
                "name": "Xu Dong-ping",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Zhang Hui",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Tang Zi-rong",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua nei ke za zhi",
        "year": 2006
    },
    "teddcARJ": {
        "id": "teddcARJ",
        "title": "Expression of NKp46 and NKG2A in peripheral blood NK cells of patients with chronic hepatitis B",
        "abstract": "Objective To determine the frequency of NK cells and expression of their receptors,including NKG2A and NKp46,in peripheral blood of patients with chronic hepatitis B.Methods Peripheral blood mononuclear cells(PBMC)were separated from patients and healthy controls.Frequency of NK cells and expression of their receptors were detected by flow cytometry.Results The number of NK cells in peripheral blood of chronic hepatitis B patients was less at immunoclearence phase(10.91%\u00b13.93%,n=21)than at immunotolerance phase(15.65%\u00b15.58%,n=15,P=0.024)and than that of healthy controls(14.23%\u00b17.37%,n=25,P=0.011).In contrast,the expression level of NKp46 was significantly higher in patients at immunoclearence phase(45.45%\u00b114.00%,n=19)than at immunotolerant phase(23.35%\u00b16.56%,n=8,P<0.001)and than that in healthy controls(31.69%\u00b113.07%,n=20,P=0.001).Moreover,the NKG2A expression level was higher in patients at immunoclearence phase(35.62%\u00b113.20%,n=19)than at immunotolerant phase(25.57%\u00b15.56%,n=8,P=0.038)and than that in healthy controls(26.80%\u00b110.49%,n=20,P=0.047).Conclusion The frequency of NK cells in peripheral blood of patients at immunoclearence phase is decreased whereas the expression of NKp46 and NKG2A is up-regulated,which is related to viral immunoclearence.",
        "keywords": [
            "NKG2A",
            "NKp46",
            "NK cells",
            "chronic",
            "hepatitis B"
        ],
        "authors": [
            {
                "name": "FAN Rong",
                "org": " Chinese PLA Postgraduate Medical School,Beijing ,China;Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Shu-ye",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "JIANG Tian-jun",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "QIN En-qiang",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Chinese PLA 302 Hospital,Beijing ,China"
            }
        ],
        "venue": "Journal of Chinese PLA Postgraduate Medical School",
        "year": 2009
    },
    "b17eFPey": {
        "id": "b17eFPey",
        "title": "Dynamic decrease in PD-1 expression correlates with HBV-specific memory CD8 T-cell development in acute self-limited hepatitis B patients.",
        "abstract": "Programmed death-1 (PD-1) upregulation can impair virus-specific CD8 T-cell responses during chronic viral infection. Whether and how PD-1 affects virus-specific memory CD8 T cells in humans with acute viral infection, however, remains largely undefined.The association between PD-1 expression and HBV-specific memory CD8 T-cell responses were longitudinally analyzed in eighteen patients with acute hepatitis B virus (HBV) infection, including ten patients with human leucocyte antigen (HLA)-A201 and eight with other HLA-A2 subtypes.At clinical onset, PD-1 was significantly up-regulated and subsequently led to the functional suppression of HBV-specific effector CD8 T cells, as blocking PD-1/PD-L1 interactions in vitro enhanced their proliferation and IFN-gamma production. Following disease resolution, HBV-specific effector CD8 T cells developed into memory T cells. During this period, the dynamic PD-1 decrease was numerically correlated with the reduction of HBV-specific CD8 T-cell frequency, phenotypically with an acquisition of CCR7, CD45RA and CD127 expressions, and functionally with the increase in proliferation and IFN-gamma production of the memory T cells.PD-1-mediated inhibitory signaling not only attenuates HBV-specific CD8 T-cell effector function during the acute phase of infection but also correlates with the development of HBV-specific memory CD8 T cells following disease resolution.",
        "keywords": [
            "programmed death-1",
            "memory t cells",
            "acute hepatitis b",
            "cd8 t cell"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Bo Jin",
                "org": ""
            },
            {
                "name": "Ji-Yuan Zhang",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Bin Xu",
                "org": "Department of Infectious Diseases, Beijing You-An Hospital, Affiliated to Capital Medical University, Beijing, China"
            },
            {
                "name": "Huifen Wang",
                "org": "Department of Infectious Diseases, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, Beijing, China"
            },
            {
                "name": "Ming Shi",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "E. John Wherry",
                "org": "Immunology Program, The Wistar Institute, Philadelphia, PA, USA"
            },
            {
                "name": "George K.K. Lau",
                "org": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Journal of hepatology",
        "year": 2009
    },
    "2YdgMsj3": {
        "id": "2YdgMsj3",
        "title": "Genetic variation of SARS coronavirus in Beijing Hospital.",
        "abstract": "To characterize genetic variation of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) transmitted in the Beijing area during the epidemic outbreak of 2003, we sequenced 29 full-length S genes of SARS-CoV from 20 hospitalized SARS patients on our unit, the Beijing 302 Hospital. Viral RNA templates for the S-gene amplification were directly extracted from raw clinical samples, including plasma, throat swab, sputum, and stool, during the course of the epidemic in the Beijing area. We used a TA-cloning assay with direct analysis of nested reverse transcription-polymerase chain reaction products in sequence. One hundred thirteen sequence variations with nine recurrent variant sites were identified in analyzed S-gene sequences compared with the BJ01 strain of SARS-CoV. Among them, eight variant sites were, we think, the first documented. Our findings demonstrate the coexistence of S-gene sequences with and without substitutions (compared to BJ01) in samples analyzed from some patients.",
        "keywords": [
            "genetic variation",
            "polymerase chain reaction",
            "china"
        ],
        "authors": [
            {
                "name": "Dong-Ping Xu",
                "org": ""
            },
            {
                "name": "Fuliang Chu",
                "org": ""
            },
            {
                "name": "Yong-Gang Li",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Ling-Xia Zhang",
                "org": ""
            },
            {
                "name": "George Fu Gao",
                "org": ""
            },
            {
                "name": "Fu-sheng Wang",
                "org": ""
            }
        ],
        "venue": "Emerging infectious diseases",
        "year": 2004
    },
    "gXa3Nx32": {
        "id": "gXa3Nx32",
        "title": "Effects of\n <i>in vivo</i>\n gene transduction of anti-MDR1 ribozyme in combination with chemotherapy on multidrug-resistant human lymphoma growth in mice",
        "abstract": "Objective: To study the effect of adenovirus- mediated transfer of anti-MDR1 ribozyme on the reversal of multidrug resistant (MDR) phenotype of P-glycoprotein (P-gp)-positive Daudi human Burkitt lymphoma\n bothin vitro andin vivo. Methods: A recombinant adenovirus expressing 196Rz (Adv-196Rz) was developed and functionally evaluated. SCID mice inoculated\n subcutaneously (s.c.) with 5\u00d7l06 Daudi/MDR20 cells were locally treated with Adv-196Rz or mock virus (Adv-Mock) at the multiplicity of infection (MOI) of 400 PFU once\n a day for 3 consecutive days. Then the mice were intraperitoneally (i.p.) administrated with vincristine (VCR) 450ng/g for\n 5 consecutive days. Results:In vitro employment of Adv-196Rz was able to interruptMDR1 transcription, to inhibit P-gp expression and to restore drug sensitivity to VCR of Daudi/MDR20 cells.In vivo, 87.5% (7/8) of Daudi/MDR20-inoculated mice treated with Adv-Mock+ VCR developed palpable tumor by the 6th week and died or were sacrificed (because\n of tumor weight >10% of body weight) by the 11th week. In contrast, among 9 Daudi/MDR20-inoculated mice treated with Adv-196Rz + VCR, only 3 developed tumor by the 11th, 13th and 14th week, respectively. 66.7%\n of mice survived >120 days in tumor-free. The survival difference between the two groups was very significant (P<0.01). Conclusion:\n Adenovirus-mediated Transfer of 196Rz can revert drug resistance of MDR tumor cells bothin vitro andin vivo. Adv-196Rz may prove useful as an adjuvant in the chemotherapy of P-gp mediated MDR human tumors.",
        "keywords": [
            "mdr",
            "gene therapy",
            "ribozyme",
            "cancer"
        ],
        "authors": [
            {
                "name": "Dong-ping Xu",
                "org": "The Institute of Infectious Diseases PLA Department of Bioengineering 100039 Beijing China"
            },
            {
                "name": "Fu-sheng Wang",
                "org": "The Institute of Infectious Diseases PLA Department of Bioengineering 100039 Beijing China"
            },
            {
                "name": "Ohnuma Takao",
                "org": "Mount Sinai School of Medicine Division of Medical Oncology 10029 New York USA"
            },
            {
                "name": "Lei Jin",
                "org": "The Institute of Infectious Diseases PLA Department of Bioengineering 100039 Beijing China"
            }
        ],
        "venue": "",
        "year": 2003
    },
    "2ssNRpFB": {
        "id": "2ssNRpFB",
        "title": "Genotyping and distribution of mutant CCR5\u039432, CCR2-641 and SDF1-3\u2032 A alleles in HIV-1 carriers and patients with sexually-transmitted diseases and chronic HBV infection",
        "abstract": "AIM: To evaluate the polymorphisms of mutant CCR5\u039432, CCR2-641 and SDF1-3\u2032 A alleles in HIV-1 carriers and patients with sexually-transmitted disease (STD) and chronic HBV infection from Han ethnic population in China. METHODS: The genomic DNAs from all 657 patients were purified from whole peripheral blood samples of HIV-1 carriers (n = 130), patients with (n = 259) and the patients with chronic HBV infection (n = 268) using QIAamp DNA Blood Mini Kit. The genotyping and distribution of CCR5\u039432, CCR2-641 and SDF1-3\u2032 A alleles were further identified by means of PCR or PCR-RFLP assays and statistical analyses. RESULTS: The mutation frequency of CCR5\u039432 alleles was 0%, 0. 19% and 0% for HIV-1 carriers, STD and HBV-infected patients, respectively, which is similar to the features with a very low frequency of CCR5\u039432 mutant in healthy individuals from Chinese Han population as previously reported. Comparatively, there was a higher frequency of CCR2-641 genes of 19.62%, 19.31% and 20. 7%, and of SDF1-3\u2032 A alleles of 27.8%, 27.4% and 26.9%, respectively, in the corresponding patients of aforementioned three groups. Statistical analyses showed that there are independent distributions of the three CCR5\u039432, CCR2-641 and SDF1-3\u2032 A alleles in the HIV-1 carriers, HBV-infected patients and the STD patients. CONCLUSIONS: The evidence of very low frequency of mutant CCR5\u039432 allele suggested that this polymorphism is unlikely to play a major role as a host genetic factor, but the functions and its implications of higher frequency of CCR2-641 and SDF1-3\u2032 A alleles remain to be further clarified in HIV-1 carriers as well as in STD cases and HBV-infected patients.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "HuiGang Liu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Weiguo Hong",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Yuesu Zhou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jing Hou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Bing Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Mingxu Liu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2002
    },
    "6E8jsiWB": {
        "id": "6E8jsiWB",
        "title": "Correlation between increased pro-inflammatory CD16~+ monocytes and severity of liver injury and fibrosis in patients with chronic hepatitis B",
        "abstract": "Objective To investigate the characteristics of intrahepatic macrophages,monocytes and their subsets and the clinical significance.Methods The frequencies and phenotypes of peripheral blood and intrahepatic monocyte subsets were analyzed in 110 patients with chronic hepatitis B(CHB),including 32 immune tolerant carriers and 78 patients with immune activation(IA).Liver biopsies from 20 IA patients were collected for immunohistochemical analysis and intrahepatic monocyte subset analysis.Results IA pa-tients displayed significant increase in peripheral and intrahepatic monocytes as well as the pro-inflammatory subset,CD16+ monocytes,which was closely associated with liver histological activity index and serum alanine aminotransferase level.Conclusions Monocytes and the pro-inflammatory subset,CD16+ monocytes,of IA patients may participate in fostering the inflammatory microenvironment and promoting liver damage in CHB patients.",
        "keywords": [
            "chronic",
            "hepatitis B",
            "monocytes",
            "Th17 cells"
        ],
        "authors": [
            {
                "name": "WANG Lu-jun",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZOU Zheng-sheng",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CHEN Li-ming",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Bao-sen",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "7ZEpLur2": {
        "id": "7ZEpLur2",
        "title": "Response to interferon-alpha treatment correlates with recovery of blood plasmacytoid dendritic cells in children with chronic hepatitis B.",
        "abstract": "To investigate whether dendritic cell changes are associated with the efficacy of interferon-alpha treatment we longitudinally analyzed circulating dendritic cells in children chronically infected with hepatitis B virus (HBV) undergoing interferon-alpha treatment.Thirty-one children with chronic hepatitis B (CHB) received interferon-alpha antiviral treatment for 52 weeks. Myeloid and plasmacytoid dendritic cell (pDCs) frequency and function were analyzed at weeks 0, 2, 12, 24, 36 and 52 in 22 CHB patients.All patients exhibited an initially rapid decrease of circulating pDC numbers and CpG-induced endogenous interferon-alpha production within 2 weeks of interferon-alpha treatment. Subsequently, all responders displayed a continuous increase of both pDC numbers and function peaking around week 12. These responses were consequently accompanied by viral clearance, hepatitis B e antigen seroconversion, and the improvement of circulating myeloid dendritic cells and type 1T helper cytokine levels. However, non-responders lacked these sequential responses compared with responders.pDCs may actively correlate with interferon-alpha therapy-induced viral clearance in pediatric patients with CHB. The recovery of blood pDC number and function may represent a prognostic marker for favourable response to interferon-alpha treatment in chronic hepatitis B.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Zheng",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China."
            },
            {
                "name": "Zhang Hongfei",
                "org": ""
            },
            {
                "name": "Chen Dawei",
                "org": ""
            },
            {
                "name": "Yao Jinxia",
                "org": ""
            },
            {
                "name": "Fu Junliang",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Journal of hepatology",
        "year": 2007
    },
    "Tcic44sN": {
        "id": "Tcic44sN",
        "title": "Treatment of calculous pyonephrosis with percutaneous nephrolithotomy via the standard access]",
        "abstract": "To investigate the feasibility of treatment for calculous pyonephrosis with first stage percutaneous nephrolithotomy under the standard access.Thirty-six cases of calculous pyonephrosis and 36 cases of urolithiasis with no pyonephrosis were treated by percutaneous nephrolithotomy. In the nephrostomy, the caliber was dilated to F24. All the operations were preformed through the EMS lithotrity system. The intrapelvic pressure was detected in the operation. The hemoculture before and after operation, the germi culture of urine, and the temperature and blood leucocyte changes after operation were recorded. All the patients were treated by antibiotics before and after the operation.All the patients were treated successfully. The average intrapelvic pressure were 23.2 cmH(2)O in non-pyonephrosis group and 22.8 cmH(2)O in pyonephrosis group. Both of the groups had 1 case of transient bacteremia after the operation. No significant difference was found in the other indices between the two groups.EMS lithotrity system is safe and feasible for treating calculous pyonephrosis with stage I percutaneous nephrolithotomy via the standard access.",
        "keywords": [
            "percutaneous nephrolithotomy",
            "intrapelvic pressure",
            "calculi",
            "pyonephrosis"
        ],
        "authors": [
            {
                "name": "ZHOU Da-qing",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            },
            {
                "name": "WANG Jian",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            },
            {
                "name": "PANG Xiang",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            },
            {
                "name": "LIU Shang-wen",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            },
            {
                "name": "YU Xiao-xiang",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            },
            {
                "name": "JIANG Bo",
                "org": " Department of Urology,303 Hospital of PLA,Nanning ,China"
            }
        ],
        "venue": "Nan fang yi ke da xue xue bao = Journal of Southern Medical University",
        "year": 2009
    },
    "wMh7eILV": {
        "id": "wMh7eILV",
        "title": "Effect of treatment of autologous cytokine-induced killer cells(CIKs) on the suppression of hepatitis B virus and its mechanism",
        "abstract": "Objective To investigate the effect of cytokine-induced killer cells(CIKs) treatment on the suppression of HBV replication and its mechanism.Methods Sixteen patients with chronic hepatitis B(CHB),hospitalized from Apr.2009 to Dec.2010 in 302 Hospital,having not received antiviral drugs treatment or immunotherapy,were enrolled in present study.The peripheral blood mononuclear cells(PBMC) were collected and induced into CIKs by cytokine cocktail,and transfused back to patients via intravenous injection.The effects of CIK-cell transfusion on HBV DNA load,changes of the cell frequency of CD3+CD56+,myeloid dendritic cells(mDCs) and plasmacytoid dendritic cells(pDCs) were observed during a 24-week follow-up period.Results After autologous CIKs transfusion,the level of HBV DNA decreased in 9 sustained virological responders at 4th,12th and 24th week(5.70,5.09 and 4.08log10 copies/ml,respectively,P<0.05 or P<0.01).The HBV DNA level showed no difference compared with the baseline(6.39log10 copies/ml) in other 7 non-virological responders.After 14d of inducible cultivation,the frequency of CIK-CD3+CD56+ cells,which were the main effectors,was significantly higher in virological responders(17.2%) than in non-virological responders(9.0%,P<0.05).After CIKs transfusion,the frequency of pDC in virological responders increased from 0.27% at the baseline to 0.39% at 4-week and 0.34% at 8-week(P<0.05),but no differences were found in non-virological responders during the follow up period.No serious clinical adverse effects were observed.Conclusions CIKs treatment can effectively inhibit the HBV replication,and it is safe for CHB patients.The mechanism of CIKs treatment on the suppression of HBV is partially attributable to the increased frequency of pDCs.",
        "keywords": [
            "lymphokine-activated",
            "killer cells",
            "chronic",
            "dendritic cells",
            "hepatitis b"
        ],
        "authors": [
            {
                "name": "TANG Zi-rong",
                "org": ".Research Center for Biological Therapy,Beijing Institute of Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "SHI Ming",
                "org": ".Research Center for Biological Therapy,Beijing Institute of Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Bing",
                "org": ".Research Center for Biological Therapy,Beijing Institute of Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": ".Research Center for Biological Therapy,Beijing Institute of Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": ".Research Center for Biological Therapy,Beijing Institute of Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ".Research Center for Biological Therapy,Beijing Institute of Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2011
    },
    "Q6zYLOiO": {
        "id": "Q6zYLOiO",
        "title": "Clinical and laboratory features and prognosis of 418 patients with influenza A(H1N1)",
        "abstract": "Objective To investigate the clinical and laboratory features and prognosis of the patients with influenza A(H1N1).Methods The clinical and laboratory data of 418 patients with influenza A(H1N1),admitted to our hospital from May 2009 to Jan.2010,were analyzed.The clinical and laboratory features and prognosis of the patients were summarized.Results Young and middle-aged adults were susceptible to influenza A(H1N1).Fever,cough and sore throat were the most frequently observed symptoms,and engorgement of pharynx and tonsillar enlargement the main signs.General influenza was commonly seen.There were significant changes in laboratory markers such as WBC count,serum iron,serum phosphorus,CK and CH50.The median duration of the clearance of viral RNA from throat swabs was 5 days.All the 418 patients were cured and discharged from hospital.Conclusions Patients with influenza A(H1N1) generally have mild signs and symptoms.Serum iron can be an early predictor for influenza A(H1N1).",
        "keywords": [
            "H1N1 subtype",
            "signs and symptoms",
            "laboratory techniques and procedures",
            "influenza A virus",
            "prognosis",
            "human",
            "influenza"
        ],
        "authors": [
            {
                "name": "YAN Hui-ying",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHOU Zhi-ping",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "JIANG Tian-jun",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FAN Rong",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "TU Bo",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "XIE Yang-xin",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "QIU Bo",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2010
    },
    "xttX8357": {
        "id": "xttX8357",
        "title": "Improved survival ratios correlate with myeloid dendritic cell restoration in acute-on-chronic liver failure patients receiving methylprednisolone therapy",
        "abstract": "",
        "keywords": [
            "case control studies",
            "immunology",
            "neuroimmunology",
            "molecular",
            "immunogenetics",
            "innate immunity",
            "adaptive immunity"
        ],
        "authors": [
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "hongwei yu",
                "org": ""
            },
            {
                "name": "yulan he",
                "org": ""
            },
            {
                "name": "jingjing zhao",
                "org": ""
            },
            {
                "name": "juan li",
                "org": ""
            },
            {
                "name": "yueke zhu",
                "org": ""
            },
            {
                "name": "qinwei yao",
                "org": ""
            },
            {
                "name": "jinhuan wang",
                "org": ""
            },
            {
                "name": "h liu",
                "org": ""
            },
            {
                "name": "shuyun shi",
                "org": ""
            },
            {
                "name": "zhengsheng zou",
                "org": ""
            },
            {
                "name": "xiangsheng xu",
                "org": ""
            },
            {
                "name": "chunbao zhou",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            },
            {
                "name": "qinghua meng",
                "org": ""
            }
        ],
        "venue": "Cellular & Molecular Immunology",
        "year": 2012
    },
    "zJYn9kEB": {
        "id": "zJYn9kEB",
        "title": "Progress of Anti-tumor Immune Efficacy of the Therapy with Argon-helium Cryosurgical System",
        "abstract": "Argon-helium cryosurgical system has been widely used in the treatment of tumors in recent years,the basic mechanism is that the ultra low temperature(<-140 \u2103) can act on the tissues and result in the formation of ice crystals in exterior and interior of cells and cellular dehydration,which will produce a series of physical and chemical changes and then result in the cell necrosis of tumor tissues.Recent studies revealed that the freezing immune efficacy resulting from the therapy is another important anti-tumor principle of Argon-helium cryosurgical system.The animal and clinical researches showed that specific antibody could be found after cryotherapy,and necrotic tumor cells after cryotherapy can result in T cell mediated killing of tumor cells as tumor vaccine.But,part of trials showed that cryotherapy could result in immune inhibition,the possible causes maybe the high-zone immune tolerance.In general,therapy with argon-helium cryosurgical system has some advantages that surigical therapy can not have,such as releving the tumor load,reducing the immune inhibitor produced bny tumor,slight postoperative stress reaction,slight body immunosuppression,activation of the body immune function by the antigen released from necrotic tumor.,which is the reliable therapeutic method for the advanced tumor patients.",
        "keywords": [
            "Crymotherapy",
            "Tumor",
            "Immunology effect",
            "Argon-helium cryosurgical system"
        ],
        "authors": [
            {
                "name": "ZHOU Lin",
                "org": "Postgraduate Medical School of PLA,No 9 Department of Infectious Disease,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Postgraduate Medical School of PLA,No 9 Department of Infectious Disease,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Medical Recapitulate",
        "year": 2008
    },
    "QTxFIN8e": {
        "id": "QTxFIN8e",
        "title": "exhaustion in typical progressors but not in long-term nonprogressors T-cell + PD-1 up-regulation is correlated with HIV-specific memory CD8",
        "abstract": "he immunoreceptor PD-1 is significantly up-regulated on exhausted CD8+ T cells during chronic viral infections such as HIV-1. However, it remains unknown whether PD-1 expression on CD8+ T cells differs between typical progressors (TPs) and long-term nonprogressors (LTNPs). In this report, we examined PD-1 expression on HIV-specific CD8+ T cells from 63 adults with chronic HIV infection. We found that LTNPs exhibited functional HIV-specific memory CD8+ T cells with markedly lower PD-1 expression. TPs, in contrast, showed significantly up-regulated PD-1 expression that was closely correlated with a reduction in CD4 T-cell number and an elevation in plasma viral load. Importantly, PD-1 up-regulation was also associated with reduced perforin and IFN-gamma production, as well as decreased HIV-specific effector memory CD8+ T-cell proliferation in TPs but not LTNPs. Blocking PD-1/PD-L1 interactions efficiently restored HIV-specific CD8+ T-cell effector function and proliferation. Taken together, these findings confirm the hypothesis that high PD-1 up-regulation mediates HIV-specific CD8+ T-cell exhaustion. Blocking the PD-1/PD-L1 pathway may represent a new therapeutic option for this disease and provide more insight into immune pathogenesis in LTNPs.",
        "keywords": [
            "viral load",
            "cd8 t cell"
        ],
        "authors": [
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Jianan Wei",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "George Fu Gao",
                "org": ""
            },
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Fu-sheng Wang",
                "org": ""
            },
            {
                "name": "Jiyuan Zhang",
                "org": ""
            },
            {
                "name": "Xicheng Wang",
                "org": ""
            },
            {
                "name": "Jun-Liang Fu",
                "org": ""
            },
            {
                "name": "Jinxia Yao",
                "org": ""
            },
            {
                "name": "Yanmei Jiao",
                "org": ""
            },
            {
                "name": "Liangen Chen",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "5TNKGZVO": {
        "id": "5TNKGZVO",
        "title": "Upregulation of OX40 ligand on monocytes contributes to early virological control in patients with chronic hepatitis C: Clinical immunology",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bin yang",
                "org": ""
            },
            {
                "name": "yu wang",
                "org": ""
            },
            {
                "name": "guohua feng",
                "org": ""
            },
            {
                "name": "tianjun jiang",
                "org": ""
            },
            {
                "name": "q zeng",
                "org": ""
            },
            {
                "name": "xiangsheng xu",
                "org": ""
            },
            {
                "name": "yuanyuan li",
                "org": ""
            },
            {
                "name": "lei jin",
                "org": ""
            },
            {
                "name": "sa lv",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "junliang fu",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            },
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "xiaoli wu",
                "org": ""
            }
        ],
        "venue": "European Journal of Immunology",
        "year": 2013
    },
    "RPSPhumc": {
        "id": "RPSPhumc",
        "title": "Imbalanced intrahepatic cytokine expression of interferon-gamma, tumor necrosis factor-alpha, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection.",
        "abstract": "This study attempts to determine expressions of intrahepatic proinflammatory and anti-inflammatory cytokines and their secreting immunocytes to evaluate their roles in the pathogenesis of acute-on-chronic liver failure (ACLF) in chronically hepatitis B virus (HBV)-infected patients.ACLF generally affects patients with established, compensated chronic liver diseases who develop an acute deterioration in liver function. In China, HBV-associated ACLF patients account for more than 80% of ACLF patients owing to a high prevalence of chronic HBV infection. Clinical observation showed that the deterioration of this disease may correlate with host immune responses, but related underlying mechanism remains largely unknown.In situ expressions of interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), and their secreting CD4, CD8 T cells, and Kupffer cells (KCs) were analyzed in the livers of patients with ACLF, chronic hepatitis B (CHB), and normal controls (NC) using immunohistochemistry.Intrahepatic proinflammatory IFN-gamma and TNF-alpha expressions were markedly up-regulated in ACLF compared with CHB and NC. However, similar anti-inflammatory IL-10 expressions were observed in ACLF and CHB. IFN-gamma overexpression correlated significantly with increased CD4 and CD8 T-cell accumulation. TNF-alpha up-regulation also correlated significantly with increased KCs.The imbalanced expression of proinflammatory and anti-inflammatory cytokines and increased accumulation of CD4, CD8 T cells, and KCs may contribute to immunopathogenesis in HBV-infected ACLF.",
        "keywords": [
            "interleukin 10",
            "tumor necrosis factor"
        ],
        "authors": [
            {
                "name": "Zou Zhengsheng",
                "org": "Department of Severe Liver Diseases, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing, China."
            },
            {
                "name": "Li Baosen",
                "org": ""
            },
            {
                "name": "Xu Dongping",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Zhao Jing-Min",
                "org": ""
            },
            {
                "name": "Zhou Guangde",
                "org": ""
            },
            {
                "name": "Sun Yanling",
                "org": ""
            },
            {
                "name": "Huang Lei",
                "org": ""
            },
            {
                "name": "Fu Junliang",
                "org": ""
            },
            {
                "name": "Yang Yongping",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Zhang Wei",
                "org": ""
            },
            {
                "name": "Zhao Jun",
                "org": ""
            },
            {
                "name": "Sun Ying",
                "org": ""
            },
            {
                "name": "Xin Shaojie",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Journal of clinical gastroenterology",
        "year": 2009
    },
    "KIAgID58": {
        "id": "KIAgID58",
        "title": "Changes of serum complement components C3, C4 and CH50 in 392 patients with H1N1 influenza A",
        "abstract": "Objective To study the changes of serum complement components C3, C4 in patients with H1N1 influenza A. Methods Serum C3, C4 levels and serum CH50 level were measured by turbindimetric immunoassay(TIA) and liposome immunoassay, respectively, in 369 patients with mild H1N1 influenza A(group A) and 23 patients with severe H1N1 influenza A(group B) during the initial 5 days after admission. Results The mean level of C3 was 1.10\u00b10.18g/L and 1.10\u00b10.19g/L, respectively, while the mean level of C4 was 0.29\u00b10.08g/L and 0.29\u00b10.08g/L, respectively, in groups A and B. The CH50 level was either slightly elevated(76%) or significantly decreased(15%). The mean level of CH50 was 48.84\u00b119.38U/ml and 57.48\u00b113.25U/ml, respectively in groups A and B(P=0.036). Conclusion Serum C3 and C4 levels are higher than normal and CH50 level is either slightly elevated or significantly decreased in patients with H1N1 influenza A at its early stage. The CH50 level is higher in patients with severe H1N1 influenza A than in those with mild H1N1 influenza A, which is of certain significance for the early warning of severe H1N1 influenza A.",
        "keywords": [
            "Influenza",
            "Human",
            "Influenza A Virus",
            "H1N1 Subtype",
            "Complement C3",
            "Complement C4"
        ],
        "authors": [
            {
                "name": "FAN Rong",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "ZHANG Xiu",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "HE Jing",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "JIANG Tian-jun",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "ZHOU Zhi-ping",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "XIE Yang-xin",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "YAN Hui-ying",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "TU Bo",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            },
            {
                "name": "ZHAO Min",
                "org": " Chinese PLA 302 Hospital, Beijing , China"
            }
        ],
        "venue": "Journal of Chinese PLA Postgraduate Medical School",
        "year": 2010
    },
    "hEcVKKlt": {
        "id": "hEcVKKlt",
        "title": "Characteristics of peripheral NK cells in hepatocellular carcinoma patients]",
        "abstract": "Functional defects in NK cells have been proposed to be responsible for the impairment of anti-tumor immune responses. However, it remained unclear whether the function of NK cells were impaired in patients with hepatocellular carcinoma. To address this issue, we analyzed the frequency and function of peripheral NK cell subsets in hepatocellular carcinoma (HCC) patients.35 HCC patients and 24 healthy controls (HC) were enrolled in the study. Peripheral NK frequency was analyzed using flow cytometry. In addition, the capacity of NK cells to produce IFN gamma and to lyse K562 cells was evaluated.In contrast with the healthy controls, the frequency of peripheral NK cells in hepatocellular carcinoma patients was decreased (12.19%+/-10.85% vs 24.01%+/-8.78%, u = 4.01, probability value less than 0.01), while the frequency of CD56(bright)CD16(neg) NK cells was increased (0.62%+/-0.39% vs 0.48%+/-0.28%, u = 1.96, probability value less than 0.05), and the frequency of CD56(dim)CD16(pos) NK cells was significantly decreased (11.59%+/-7.49% vs 22.66%+/-8.84%, u = 3.92, probability value less than 0.01). In addition, peripheral NK cells from HCC patients exhibited decreased capacity to produce IFN gamma (effective cells 13.31%) and to lyse K562 cells (mixed ratio 30:1, 10:1, 1:1, effective cells 16.72%+/-7.33% vs 26.29%+/-12.36%, u = 2.52, P less than 0.05, 8.01%+/-4.40% vs 13.09%+/-5.03%, u = 3.32, probability value less than 0.05, 3.51%+/-2.82% vs 3.42%+/-1.64%, u = 1.56, probability value more than 0.05, respectively) as compared with healthy subjects.Anti-tumor activity of NK cells in HCC patients was impaired.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhou Lin",
                "org": "Liver Cancer Therapy and Research Center, People's Liberation Army 302 Hospital, Beijing 100039, China."
            },
            {
                "name": "Cai Lun",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Yang Yong-ping",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2010
    },
    "JlMbBKlM": {
        "id": "JlMbBKlM",
        "title": "The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope.",
        "abstract": "HBcAg18-27 (FLPSDFFPSV, V27 epitope) is a dominant HLA-A2-restricted epitope in hepatitis B virus (HBV)-infected patients. So far, the occurrence of the epitope has not been assessed in China, where the prevalence of chronic HBV infection is high. In this report, we sequenced the HBV core gene in 105 Chinese patients with chronic HBV infection. Approximately 93.3% (98/105) of the core genes that were sequenced contained mutations with amino acid substitution at position 27 of the core protein: a mutation from a valine to an isoleucine (V27I). The mutant peptide (FLPSDFFPSI, I27) was found to bind to the HLA-A2 molecule with high affinity and elicit specific cytotoxic T lymphocyte (CTL) responses in acutely infected hepatitis B patients. In CTL assays using I27-specific pentamer staining, the V27 epitope showed a cross-reactive T cell response specific for the I27 epitope, but not vice versa. These findings provide important insights for the design of HBcAg18-27-based vaccines in the future.",
        "keywords": [
            "mutation",
            "acute hepatitis b",
            "18\u201327 amino acid of hbcag (flpsdffpsv)",
            "v27",
            "hbcag",
            "i27",
            "mutant hbcag18\u201327 (flpsdffpsi)",
            "immunology",
            "wild type of hbcag18\u201327 (flpsdffpsv)",
            "cytotoxic t lymphocyte",
            "epitope",
            "hbv",
            "chb",
            "clinic immunology and viral immunology",
            "hepatitis b virus",
            "hepatitis b core antigen",
            "hbcag18\u201327",
            "chronic hepatitis b",
            "ahb"
        ],
        "authors": [
            {
                "name": "Heng-Gui Liu",
                "org": "Graduate University of Chinese Academy of Sciences, Beijing 100080, China"
            },
            {
                "name": "Wei-wei Chen",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Zhen-Ping Fan",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Hui-ying Yang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Ming Shi",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Zheng Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Shen-Shun Luan",
                "org": "Center for Molecular Virology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China"
            },
            {
                "name": "Hui Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Peng Lu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing Institute of Infectious Diseases, Beijing 100039, China"
            },
            {
                "name": "Po Tien",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2007
    },
    "u4euD47B": {
        "id": "u4euD47B",
        "title": "Detection of HBcAg-specific cytotoxic lymphocytes and their association with clinical status in patients with hepatitis B]",
        "abstract": "To investigate the difference of host immune response specific to hepatitis B virus (HBV) infections between acute self-limited and chronic persistent hepatitis by quantitative analysis of HLA-A * 2402-restricted HBcAg-specific cytotoxic T lymphocyte cells (CTL) cells.The frequency of HBV-specific CTL cells in the peripheral blood mononuclear cells (PBMCs) from 20 patients infected with HBV were quantified by ELISPOT assays and flow cytometry using one HLA-A * 2402-HBV, 7 with acute HB and 13 with chronic HB, peptide tetrameric complex.High frequencies of circulating HBcAg-specific CTL cells were detected in most individuals with acute HBV infection while the number of these cells was significantly reduced at the convalescent stage. HBcAg-specific CTL cells were not detected in the PBMC from individuals with chronic HBV infection except for one patient with an acute infection exacerbation.HBcAg-specific CTL cells may play a crucial role in complete clearance of HBV from patients with acute HBV hepatitis.",
        "keywords": [],
        "authors": [
            {
                "name": "Fan Zhen-ping",
                "org": "Research Center of Biological Therapy, PLA 302nd Hospital, Beijing 100039, China."
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            },
            {
                "name": "Xu Dong-Ping",
                "org": ""
            },
            {
                "name": "Chu Fu-liang",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Zhou Yu",
                "org": ""
            },
            {
                "name": "Zhang Ling-xia",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2004
    },
    "TRBpKlHw": {
        "id": "TRBpKlHw",
        "title": "Population survey of CCR5 delta32, CCR5 m303, CCR2b 64I, and SDF1 3'A allele frequencies in indigenous Chinese healthy individuals, and in HIV-1-infected and HIV-1-uninfected individuals in HIV-1 risk groups.",
        "abstract": "The aim of this study is to determine in indigenous Chinese ethnic groups the frequencies of the chemokine (SDF1 3'A) and chemokine receptors (CCR5 delta32, CCR5 m303, and CCR2b 64I) HIV-1/AIDS restriction alleles. The study includes two cohorts; the first comprised 3165 indigenous healthy subjects representing eight ethnic groups: Han (n = 1406), Uygur (n = 316), Mongolia (n = 134), Hui (n = 386), Tibetan (n = 330), Zhuang (n = 378), Dai (n = 101), and Jingbo (n =114). The second cohort consisted of 330 HIV-1-infected (86 subjects infected by sexual transmission and 198 subjects infected by HIV-1-contaminated blood or by sharing injection equipment; the remaining 46 subjects said nothing about HIV-1 transmission) and 474 HIV-1-uninfected Han Chinese belonging to one of two HIV-1 high-risk groups: intravenous drug users (n = 215) and individuals with sexually transmitted diseases (n = 259). Genotypes for the four genes were obtained using PCR (CCR5 delta32) or PCR-restriction fragment length polymorphism. Randomly selected amplified PCR products were further confirmed by direct DNA sequencing. The variant allele frequencies were determined to be 0% to 3.48% for CCR5 delta32, 0% for CCR5 m303, 16.23% to 28.79% for CCR2b 64I, and 17.70% to 27.76% for SDF1 3'A in Chinese healthy individuals from eight ethnic groups. These findings show that allele frequencies differ among the eight Chinese ethnic groups for CCR5 delta32, CCR2b 64I, and SDF1 3'A and that the CCR5 m303 and CCR5 delta32 mutant alleles were absent or infrequent in Chinese, which may be helpful for studies of specific anti-HIV-1 vaccine trials and coreceptor inhibitor drug targets in Chinese populations. Furthermore, we observed no significant differences in allele or genotypic frequencies between HIV-1-infected and HIV-1-uninfected groups from the Han ethnic group. Our finding is the first reporting that there is likely no effect of the examined polymorphisms in our study on HIV-1 transmission in the Chinese Han population, However, the genetic effects of these and other AIDS-modifying polymorphisms on the pathogenesis and clinical outcome of HIV-1/AIDS diseases is under investigation in Chinese populations.",
        "keywords": [],
        "authors": [
            {
                "name": "Wang Fu-Sheng",
                "org": "Division of Biological Engineering, Beijing Institute of Infectious Disease, Beijing Hospital of Infectious Disease, Beijing, China. fswang@public.bta.net.cn"
            },
            {
                "name": "Hong Wei-Guo",
                "org": ""
            },
            {
                "name": "Cao Yunzhen",
                "org": ""
            },
            {
                "name": "Liu Ming-Xu",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Hu Liang-Ping",
                "org": ""
            },
            {
                "name": "Wang Zhe",
                "org": ""
            },
            {
                "name": "Feng Tie-Jian",
                "org": ""
            },
            {
                "name": "Hou Jing",
                "org": ""
            },
            {
                "name": "Zhang Bing",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Xu Dong-Ping",
                "org": ""
            },
            {
                "name": "Lei Zhou-Yun",
                "org": ""
            },
            {
                "name": "Wang Bo",
                "org": ""
            },
            {
                "name": "Liu Zheng-Dong",
                "org": ""
            },
            {
                "name": "Ye Jun-Jie",
                "org": ""
            },
            {
                "name": "Peng Lin",
                "org": ""
            },
            {
                "name": "Qiu Ya",
                "org": ""
            },
            {
                "name": "Winkler Cheryl",
                "org": ""
            }
        ],
        "venue": "Journal of acquired immune deficiency syndromes",
        "year": 2003
    },
    "HkhaADE9": {
        "id": "HkhaADE9",
        "title": "Immune reconstitution and immunotherapy for AIDS",
        "abstract": "Chronic HIV-1 infection mainly destroys the immune system in humans. Although highly active antiretroviral therapy can reconstitute the host immunity in some treated patients by inhibiting the viral replication,it hardly clears in vivo viral reservoir due to its limitations. Recently,some new therapeutic strategies and measures have occurred,which finally aim at the immune reconstitution of chronically HIV-1-infected patients. This article reviews the immune reconstitution and immunotherapy for AIDS.",
        "keywords": [
            "immune reconstitution",
            "immunotherapy",
            "HIV"
        ],
        "authors": [
            {
                "name": "Zhang Zheng",
                "org": " PLA Infectious Disease Institute,Beijing ,China"
            },
            {
                "name": "Wang Fusheng",
                "org": " PLA Infectious Disease Institute,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2009
    },
    "vz4fxnVl": {
        "id": "vz4fxnVl",
        "title": "CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection.",
        "abstract": "T-cell immunity to hepatitis B virus (HBV) is involved in both viral clearance and the pathogenesis of cirrhosis and hepatocellular carcinoma following chronic HBV infection. It is therefore of great interest to analyze whether genetic polymorphism of genes involved in the immune response may determine the outcomes of chronic HBV infection. Here we report that CD24 polymorphisms affect the risk and progression of chronic HBV infection. Thus the CD24 P170(T) allele, which is expressed at a higher level, is associated with an increased risk of chronic HBV infection. Among the chronic HBV patients this allele shows recessive association with more rapid progression to liver cirrhosis and hepatocellular carcinoma in comparison to the P170(C) allele. In contrast, a dinucleotide deletion at position 1527-1528 (P1527(del)), which reduces CD24 expression, is associated with a significantly reduced risk of chronic HBV infection. To confirm the role for CD24 in liver carcinogenesis, we compared the size of liver tumor developed in CD24(-/-) and CD24(+/-) HBV transgenic mice. Our data demonstrate that targeted mutation of CD24 drastically reduced the sizes of spontaneous liver cancer in the HBV transgenic mice.These data demonstrate that genetic variation of CD24 may be an important determinant for the outcome of chronic HBV infection.",
        "keywords": [
            "immune response",
            "genetic variation",
            "polymorphism",
            "risk factors",
            "carcinogenesis",
            "oncogenic viruses",
            "genes"
        ],
        "authors": [
            {
                "name": "Dongling Li",
                "org": ""
            },
            {
                "name": "Linghua Zheng",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Yuesu Zhou",
                "org": ""
            },
            {
                "name": "Haiying Li",
                "org": ""
            },
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Peishuang Du",
                "org": ""
            },
            {
                "name": "Lizhong Wang",
                "org": ""
            },
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Guo-Yun Chen",
                "org": ""
            },
            {
                "name": "Pan Zheng",
                "org": ""
            },
            {
                "name": "Yang Liu",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Shengdian Wang",
                "org": ""
            }
        ],
        "venue": "Hepatology (Baltimore, Md.)",
        "year": 2009
    },
    "YTjO09iR": {
        "id": "YTjO09iR",
        "title": "Adenovirus-mediated transfer of anti-MDR1 ribozyme in the treatment of multidrug-resistant human lymphoma in SCID mice]",
        "abstract": "To evaluate the effect of adenovirus-mediated transfer of anti-MDR1 ribozyme on restoring drug sensitivity of multidrug-resistant human lymphoma both in vitro and in SCID mice.A recombinant adenovirus expressing ribozyme against codon 196 of MDR1 mRNA (Ad-196MDR1-Rz) was developed through cotransfection of shuttle vector pCA14 containing 196MDR1-Rz and rescue vector pJM17 into human embryonic kidney cell line 293. In vitro Daudi/MDR20, a MDR1-mediated drug-resistant human lymphoma cell line, was transduced by Ad-196MDR1-Rz at MOI of 400 pfu/cell. RT-PCR and FACS analyses were used to evaluate the MDR1 expression in both transcriptional and translational levels. MTT assay was used for analysis of drug resistance. In vivo, SCID mice were inoculated subcutaneously by 5 x 10(6) Daudi/MDR20 or parental Daudi/wt cells. Adenovirus was injected locally. Vincristine (VCR) was given intraperitoneally.In vitro transduction of Ad-196MDR1-Rz to Daudi/MDR20 cells was able to interrupt MDR1 transcription, inhibit P-gp expression and restore drug sensitivity to VCR. Of SCID mice bearing Daudi/MDR20 cells, tumor free rate and long term survival were 66.7% (6/9) and > 120 days in the therapeutic group of Ad-196MDR1 + VCR vs 12.5% (7/8) and none survived > 120 days in the control groups of Ad-Mock + VCR or VCR alone. The difference was very statistically significant.Ad-mediated transfer of 196MDR1-Rz can revert drug resistance of MDR tumor cells both in vitro and in vivo. Ad-196MDR1-Rz may be helpful as an adjuvant in the chemotherapy of P-gp mediated MDR human tumor.",
        "keywords": [],
        "authors": [
            {
                "name": "Xu Dongping",
                "org": "Division of Biological Engineering, Beijing Institute of Infectious Diseases, Beijing Hospital of Infectious Diseases, Beijing 100039, China."
            },
            {
                "name": "Wang Fusheng",
                "org": ""
            },
            {
                "name": "Ohnuma Takao",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            }
        ],
        "venue": "Zhonghua zhong liu za zhi [Chinese journal of oncology]",
        "year": 2002
    },
    "bZdGK4X3": {
        "id": "bZdGK4X3",
        "title": "Hepatitis B related liver failure treated with hepatocyte transplantation:A two-year follow-up",
        "abstract": "BACKGROUND:Hepatocyte transplantation has attracted more and more attention as a therapeutic measure for liver failure and genetic metabolic liver diseases.OBJECTIVE:To evaluate the efficacy and safety of human hepatocyte transplantation in treating hepatitis B related liver failure in one case by a 2-year follow-up.DESIGN:A case-report of 2-year follow-up.SETTING:No.9 Department of Infectious Diseases,Bioengineering Research Room,the 302 Hospital of Chinese PLA.PARTICIPANT:One inpatient with hepatitis B related liver failure was selected from the 302 Hospital of Chinese PLA,and she was diagnosed according the laboratory tests.The transplanted hepatocytes were originated from the healthy liver of a 24-year-old man,who had signed the protocol for liver donation before death.METHODS:The hepatocyte transplantation was completed in the Department of Radiology,the 302 Hospital of Chinese PLA in December 2004.Liver was isolated to obtain human primary hepatocytes,and then cryopreserved.The hepatocytes were transplanted into recipient spleen via femoral vein after resuscitation.The clinical symptoms,changes of blood biochemical indexes,and changes of spleen MRI signals were observed before and after operation.The patient was reexamined every half a year after operation,including liver function,blood coagulation function,B-mode ultrasonography,gastroscopy and MRI,and she was followed up for 2 years.MAIN OUTCOME MEASURES:Liver function,blood coagulation function,imaging indexes,immunological indexes,complication and rejection.RESULTS:\u2460 Totally(1-2)\u00d71010 hepatocytes were harvested,and the viability of rewarmed hepatocytes was 60%,and finally 2\u00d7109 hepatocytes were transplanted.\u2461 Two months later,the clinical symptoms of the recipient were obviously ameliorated,and serum bilirubin and aspartate aminotransferase(AST) were obviously decreased,while prothrombin activity was markedly increased.20 months later,the MRI results showed that there was hepatocyte image in spleen.Two years after operation,the total bilirubin level was 20 \u03bcmol/L,direct bilirubin level was 7 \u03bcmol/L,alanine aminotransferase was 416.75 nkat/L,AST was 533.44 nkat/L,albumin was 37 g/L,prothrombin activity was 90%,which were all obviously ameliorated as compared with those before operation(474.5 \u03bcmol/L,340.3 \u03bcmol/L,400.08 nkat/L,1 200.24 nkat/L,38 g/L,25%).The patient left the hospital 2 months later and could do light-burdened job.No complications of hydroperitonia and liver function failure,etc.were observed,and no rejection occurred.Several reexaminations by B-mode ultrasonography all indicated the further aggravations of liver cirrhosis and esophageal varices.She was admitted to hospital for twice because of esophageal varices bleeding,and cured by endoscopic variceal sclerosis therapy.CONCLUSION:Hepatocyte transplantation can ameliorate liver function without rejection,but it cannot relieve portal hypertension.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhou Lin",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Yang Yong-ping",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Wang Chun-ping",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Ma Wei",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Wang Hua-ming",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Ma Xue-mei",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Feng Yong-yi",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Su Shu-hui",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Wang Fu-sheng",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "An Lin-jing",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Qi Dong-ying",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Lu Yin-ying",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Chen Yan",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            },
            {
                "name": "Jia Hong-jun",
                "org": " No.9 Department of Infectious Diseases,the 302 Hospital of Chinese PLA,Beijing ,China"
            }
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2007
    },
    "vRlGgU0B": {
        "id": "vRlGgU0B",
        "title": "B Function in Patients with Chronic Hepatitis Immune Cells Significantly Suppresses T Cell B7-H1 Up-Regulation on Myeloid Dendritic",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shengdian wang",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            },
            {
                "name": "yonggang li",
                "org": ""
            },
            {
                "name": "ming shi",
                "org": ""
            },
            {
                "name": "jiyuan zhang",
                "org": ""
            },
            {
                "name": "liangen chen",
                "org": ""
            },
            {
                "name": "weiwei chen",
                "org": ""
            },
            {
                "name": "zhidong zhang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2012
    },
    "Bn1QMiuj": {
        "id": "Bn1QMiuj",
        "title": "Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients: Stem cells treat liver cirrhosis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "hu lin",
                "org": ""
            },
            {
                "name": "ming shi",
                "org": ""
            },
            {
                "name": "ruonan xu",
                "org": ""
            },
            {
                "name": "junliang fu",
                "org": ""
            },
            {
                "name": "jiyun lv",
                "org": ""
            },
            {
                "name": "liming chen",
                "org": ""
            },
            {
                "name": "sa lv",
                "org": ""
            },
            {
                "name": "yuanyuan li",
                "org": ""
            },
            {
                "name": "shuangjie yu",
                "org": ""
            },
            {
                "name": "hua geng",
                "org": ""
            },
            {
                "name": "lei jin",
                "org": ""
            },
            {
                "name": "george k k lau",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Journal of Gastroenterology and Hepatology",
        "year": 2012
    },
    "xtKDbVbc": {
        "id": "xtKDbVbc",
        "title": "Effects of heat shock protein gp96 on human dendritic cell maturation and CTL expansion.",
        "abstract": "We reported previously that heat shock protein gp96 and its N-terminal fragment were able to stimulate CTL expansion specific for a HBV peptide (SYVNTNMGL) in BALB/c mice. Here we characterized the adjuvant effects of gp96 on human HLA-A2 restricted T cells. Full-length gp96 isolated from healthy human liver and recombinant fragments both from prokaryotic cells and eukaryotic cells were analyzed for their ability to stimulate maturation of human dendritic cells. It was found that in vitro these proteins were capable of maturating human monocyte-derived dendritic cells (MDDC) isolated from healthy donors as well as from HBV-positive, hepatocellular carcinoma (HCC) patients. In HLA-A2.1/Kb transgenic mice, gp96 and the recombinant fragments were found to augment CTL response specific for the HBcAg(18-27) FLPSDFFPSV peptide of hepatitis B virus.",
        "keywords": [
            "transgenic mice",
            "monocyte-derived dendritic cells",
            "heat shock protein gp96",
            "peptide",
            "cytotoxic t lymphocyte",
            "hepatitis b virus",
            "heat shock protein",
            "n terminal"
        ],
        "authors": [
            {
                "name": "Yuxia Zhang",
                "org": "Graduate School of the Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Yanlu Zan",
                "org": "Graduate School of the Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Ming Shan",
                "org": "Molecular Virology Research Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Changmei Liu",
                "org": "Molecular Virology Research Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "Ming Shi",
                "org": "Beijing 302 Hospital, Beijing 100039, PR China"
            },
            {
                "name": "Wei Li",
                "org": "Beijing Red Cross Blood Center Histocompatibility Laboratory, Beijing 100088, PR China"
            },
            {
                "name": "Zhixin Zhang",
                "org": "Beijing Red Cross Blood Center Histocompatibility Laboratory, Beijing 100088, PR China"
            },
            {
                "name": "Na Liu",
                "org": "Beijing Red Cross Blood Center Histocompatibility Laboratory, Beijing 100088, PR China"
            },
            {
                "name": "Fusheng Wang",
                "org": "Beijing 302 Hospital, Beijing 100039, PR China"
            },
            {
                "name": "Weidong Zhong",
                "org": "Gilead Sciences, Inc. Foster City, CA 94404, USA"
            },
            {
                "name": "Fulian Liao",
                "org": "Molecular Virology Research Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China"
            },
            {
                "name": "George F. Gao",
                "org": ""
            },
            {
                "name": "Po Tien",
                "org": ""
            }
        ],
        "venue": "Biochemical and biophysical research communications",
        "year": 2006
    },
    "CzOpCHNK": {
        "id": "CzOpCHNK",
        "title": "Preferential loss of Th17 cells is associated with CD4 T cell activation in patients with 2009 pandemic H1N1 swine-origin influenza A infection.",
        "abstract": "Very limited evidence has been reported on host T cell responses to the pandemic H1N1 swine-origin influenza A virus (S-OIV) infection in humans. Therefore, we investigated the proportions of peripheral T cell subsets and analyzed the relationship of T helper subset changes with T cell activation during this infection. We found that these S-OIV-infected patients exhibited rapid lymphopenia, T cell activation and preferential loss of Th17 subset at the early stage of acute infection. Statistical analysis indicated that CD4 depletion and loss of Th17 cells, rather than Th1 or Treg cells, were correlated with CD4 T cell activation. More importantly, up-regulated IFN-\u03b1 likely contributed to the functional loss of Th17 cells. Thus, rapidly generalized lymphopenia, preferential loss of Th17 population and T cell activation presented as characteristics of the early immune response in S-OIV-infected patients. These findings, therefore, may be helpful for an earlier diagnosis and further studies of immune pathogenesis of S-OIV infection.",
        "keywords": [
            "activation",
            "pandemic h1n1 swine-origin influenza a virus",
            "t cell depletion",
            "th17 cells"
        ],
        "authors": [
            {
                "name": "Tian-Jun Jiang",
                "org": ""
            },
            {
                "name": "Ji-Yuan Zhang",
                "org": ""
            },
            {
                "name": "Wen-Gang Li",
                "org": "Department of Infectious Diseases, Beijing 302 Hospital, 100039, China"
            },
            {
                "name": "Yang-Xin Xie",
                "org": "Department of Infectious Diseases, Beijing 302 Hospital, 100039, China"
            },
            {
                "name": "Xin-Wei Zhang",
                "org": "Department of Infectious Diseases, Beijing 302 Hospital, 100039, China"
            },
            {
                "name": "Yong Wang",
                "org": "PLA Institute of Disease Control and Prevention, Beijing 100071, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, 100039, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Min Zhao",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2010
    },
    "EVeFv5wm": {
        "id": "EVeFv5wm",
        "title": "The characterization of regulatory T cells in peripheral blood of HBV-infected patients]",
        "abstract": "CD4(+)CD25(high) regulatory T cells (Treg) have been shown to play an important role in maintaining peripheral tolerance against self and foreign antigens, and in suppressing T cell immune response. Our aim was to characterize circulating Treg in HBV-infected patients.Treg in peripheral blood from 72 chronic hepatitis B (CHB) patients, 16 acute hepatitis B (AHB) patients and 32 healthy subjects were quantitatively analyzed using flow cytometry. Serum HBV markers were evaluated for each subject. HBV-DNA levels were measured using real-time RT-PCR.CHB patients presented a higher fraction of circulating Treg (3.9% +/- 1.4%) than those in AHB patients (3.1% +/- 0.9%) (P < 0.05), but were similar to healthy controls (3.5% +/- 0.7%). CHB patients with greater than 10(7) copies/ml of serum HBV DNA loads had a higher frequency (4.5% +/- 1.9%) of circulating Treg than health controls (P < 0.01) and the patients with less than 10(7) copies/ml of serum viral loads (3.4% +/- 0.7%). A correlation was found between circulating Treg and HBV DNA level (r = 0.32, P < 0.01). Furthermore, Treg was more frequent in convalescent phase (6.0% +/- 1.7%) than in early acute phase (3.0% +/- 0.6%).Increased peripheral Treg is found to be associated with HBV replication in chronic hepatitis B. In acute HBV infection, Treg is less frequent in early phase. The related mechanisms is under further investigation.",
        "keywords": [
            "Hepatitis B",
            "Immune tolerance",
            "T-lympocytes"
        ],
        "authors": [
            {
                "name": "Junliang Fu",
                "org": "PLA Postgraduate Medical School(PLA Postgraduate Medical School,Chinese PLA Postgraduate Medical School,Militery Postgraduate Medical School,Postgraduate Medical School,Team of PLA Postgraduate Medical School),Beijing,China"
            },
            {
                "name": "XU Dong-ping",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            },
            {
                "name": "ZHAO Ping",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            },
            {
                "name": "CHEN Li-ming",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            },
            {
                "name": "ZHANG Hui",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            },
            {
                "name": "Chunbao Zhou",
                "org": "PLA Postgraduate Medical School(PLA Postgraduate Medical School,Chinese PLA Postgraduate Medical School,Militery Postgraduate Medical School,Postgraduate Medical School,Team of PLA Postgraduate Medical School),Beijing,China"
            },
            {
                "name": "YAO Jin-xia",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            },
            {
                "name": "Rong Yi-hui",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". Research Center of Biological Therapy and the Sixth Department of Infectious Diseases, 302 Hospital, PLA Postgrduate Medical School, Beijing , ChinaCorresponding author:WANG Fu-sheng , Email: fswang@public.bta.net.cn"
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2006
    },
    "4Qp2lLVL": {
        "id": "4Qp2lLVL",
        "title": "Attrition of CMV-specific CD8 T cells in human during acute self-limited hepatitis B virus infection",
        "abstract": "Objective Attrition of heterogonous virus-specific CD8+ T cells,which precede robust antiviral immune response,has been demonstrated in murine viral infection,little is known regarding this phenomenon in human viral infections.Whether PD-1 affects CMV-specific CD8 T cells in humans with acute hepatitis B virus infection(AHB) remain largely undefined.This study aimed to characterize the number of CMV-specific CD8 T cells and the PD-1 expression by CMV-specific CD8 T cells in AHB at clinical onset,and further address the association between the PD-1 expression and the attrition of CMV-specific CD8 T cells.Methods Peripheral CMV-specific CD8 T cells from 12 HLA-A2-positive AHB patients were quantitatively analyzed,and PD-1 on CMV-specific CD8 T cells were measured using flow cytometry.Furthermore,after PD-1 /PD-L1 pathway was blockaded,the spontaneous apoptosis of CMV-specific CD8 T cells was detected.Serum ALT levels,HBsAg,HBsAb and HBV-DNA levels were evaluated for each subject.Results In this study,we observed that CMV-specific CD8 T cells displayed numerical decline and functional impairment in the early phase of acute infection,whereas PD-1 expression was significantly up-regulated by these CMV-specific CD8 T cells.This early PD-1 up-regulation was found to be closely associated with the increased apoptotic sensitivity of CMV-specific CD8 T cells.Blockade of the PD-1-mediated pathway with anti-PD-L1 in vitro significantly restored the CMV-specific CD8 T cell IFN-\u03b3 production.Conclusion These results indicate that acute HBV infection may induce the attrition of CMV-specific CD8 T cells during the early stage of HBV infection and PD-1 plays a crucial role in the attrition of CMV-specific CD8 T cells.This early attrition of CMV-specific CD8 T cells might make room for newly formed HBV-specific T cells within the immune system and facilitate the mounting of a strong anti-HBV T cell response.",
        "keywords": [
            "Immune inhibitory pathway",
            "Attrition of memory T cells",
            "Heterologous virus",
            "Acute hepatitis B"
        ],
        "authors": [
            {
                "name": "JIN Lei",
                "org": ". 302 Military Hospital of China,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-Yuan",
                "org": ". 302 Military Hospital of China,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": ". 302 Military Hospital of China,Beijing ,China"
            },
            {
                "name": "WANG Fu-Sheng",
                "org": ". 302 Military Hospital of China,Beijing ,China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2009
    },
    "gJ2y48pq": {
        "id": "gJ2y48pq",
        "title": "Liver fibrosis: mechanisms of immune-mediated liver injury.",
        "abstract": "Liver fibrosis and its end-stage consequence, cirrhosis, represent the final common pathway of virtually all chronic liver diseases. Research into hepatic stellate cell activation, imbalance of the extracellular matrix synthesis and degradation and the contribution of cytokines and chemokines has further elucidated the mechanisms underlying fibrosis. Furthermore, clarification of changes in host adaptive and innate immune systems has accelerated our understanding of the association between liver inflammation and fibrosis. Continued elucidation of the mechanisms of hepatic fibrosis has provided a comprehensive model of fibrosis progression and regression. This review summarizes the current concepts of improvements that have been made in the field of fibrosis.",
        "keywords": [
            "neuroimmunology",
            "immunology",
            "immunogenetics",
            "innate immunity",
            "adaptive immunity",
            "molecular"
        ],
        "authors": [
            {
                "name": "Xu Ruonan",
                "org": "Liver Disease Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China."
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Cellular & molecular immunology",
        "year": 2012
    },
    "AeTZYUiH": {
        "id": "AeTZYUiH",
        "title": "Activated plasmacytoid dendritic cells act synergistically with hepatitis B core antigen-pulsed monocyte-derived dendritic cells in the induction of hepatitis B virus-specific CD8 T-cell response.",
        "abstract": "It is important to further improve the efficiency of hepatitis B core antigen-pulsed monocyte-derived dendritic cell (core-DC) vaccine in clinical immunotherapy for chronic hepatitis B virus (HBV) infection in humans. Our study shows that CpG-treated plasmacytoid dendritic cells (pDCs) can efficiently promote core-DC terminal maturation and increase interleukin-12 production. These CpG-activated pDCs can act synergistically in vitro with core-DCs in inducing autologous HBV-specific CD8 T-cell proliferation and interferon (IFN)-gamma production. This promotion was mainly dependent on pDC-derived IFN-alpha, because blockade of IFN-alpha nearly completely aborted the effects of pDCs on core-DCs. In addition, the supernatants derived from CpG-treated peripheral blood mononuclear cells can also effectively improve the aforementioned maturation and function of core-DCs. These findings will facilitate a better understanding of how the pDCs regulate myeloid dendritic cell-mediated immune responses, and highlight the notion that manipulating pDCs might have implications in DC vaccine therapy for patients with chronic hepatitis B.",
        "keywords": [
            "cpg-treated core-dcs",
            "blood dendritic cell antigen",
            "apc",
            "percp",
            "toll-like receptor",
            "hepatitis b",
            "phycoerythrin",
            "modcs",
            "dendritic cells",
            "cpg-dcs",
            "pe",
            "plasmacytoid dendritic cells",
            "pdc-dcs",
            "fluorescein isothiocyanate",
            "hepatitis b core antigen-pulsed dcs",
            "pdc + cpg-dcs cpg-activated pdc-treated core-dcs cpg-sup supernatants produced by cpg-treated pbmcs sup-dcs cpg-sup-treated core-dcs rhifn-\u03b1 recombinant human ifn-\u03b1",
            "core-dcs",
            "peridin chlorophyll protein",
            "interferon-alpha",
            "pdc-treated core-dcs",
            "bdca",
            "monocyte-derived dcs",
            "cd8 t cells",
            "dcs",
            "allophycocyanin",
            "fitc",
            "immune response",
            "cd8 t cell",
            "peripheral blood mononuclear cell"
        ],
        "authors": [
            {
                "name": "Weiwei Chen",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Liangen Chen",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Junliang Fu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Feng Shi",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Bing Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Hui Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2008
    },
    "drAzh29f": {
        "id": "drAzh29f",
        "title": "BTLA Characterization and its association with disease progression in patients with chronic HIV-1 infection.]",
        "abstract": "To characterize the B and T lymphocyte attenuator (BTLA, CD272) expression on CD4(+); and CD8(+); T lymphocytes during chronic HIV-1 infection, and analyze the clinical significance for its expression and disease progression.BTLA expression on T cells in peripheral blood from 34 patients with chronic HIV-1 infection and 15 healthy donors was measured using flow cytometry. The correlation between BTLA expression and CD4 T cell counts and virus load was also analyzed.BTLA expression on both CD4 and CD8 T cells was significantly down-regulated in HIV-1-infected subjects compared to HCs and the down-regulation of BTLA expression on total T-cell subsets was associated with the progression of HIV-1 infection. BTLA expression on CD4 T cells was positively correlated with CD4 T cell counts and negatively correlated with HIV virus load.BTLA signaling pathway may play an important role in the unbalance between the stimulating and inhibitory signal which results in the general immune activation during chronic HIV-1 infection. Manipulation of BTLA inhibitory pathway may present an alternative strategy for overcoming immune activation for this disease.",
        "keywords": [
            "btla",
            "chronic hiv-1 infection",
            "immune inhibitory pathway"
        ],
        "authors": [
            {
                "name": "XU Xiang-sheng",
                "org": " Research Center for Biological Therapy, Beijing 302 Hospital, Beijing , China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " Research Center for Biological Therapy, Beijing 302 Hospital, Beijing , China"
            },
            {
                "name": "GU Lan-lan",
                "org": " Research Center for Biological Therapy, Beijing 302 Hospital, Beijing , China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " Research Center for Biological Therapy, Beijing 302 Hospital, Beijing , China"
            }
        ],
        "venue": "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",
        "year": 2009
    },
    "p5tnQxew": {
        "id": "p5tnQxew",
        "title": "The efficacy of miRNA122, a novel therapeutic target, for predicting the progression of hepatocellular carcinoma (HCC)",
        "abstract": "",
        "keywords": [
            "down regulation",
            "innate immunity",
            "neuroimmunology",
            "adaptive immunity",
            "lipid metabolism",
            "micrornas",
            "immunogenetics",
            "predictive value of tests",
            "immunology"
        ],
        "authors": [
            {
                "name": "lifeng wang",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Cellular & Molecular Immunology",
        "year": 2012
    },
    "EhJzc3Q6": {
        "id": "EhJzc3Q6",
        "title": "Effect of B7-H1/PD-1 costimulatory pathway on immune function of HBV-specific T lymphocytes in patients with chronic hepatitis B virus infection",
        "abstract": "Objective To investigate the effect of BT-H1/PD-1 costimulatory signal pathway on immune function of HBV-specific T lymphocytes in chronic hepatitis B(CHB)patients.Methods The expression of B7- H1 on circulating myeloid dentritic cells and PD-1 on Tlymphocytes in CHB patients and health control was detect- ed by FACS(fluorescence-activated cell sorter);Monocyte-derived DC from patients were differentiated in vitro from peripheral blood monocytes and pulsed with HBcAg.Pulsed MoDC were promoted maturation with\"cytokine cocktails\"(TNF-\u03b1,IL-6,IL-1\u03b2,PGE_2)and cecultured with autologous T cells.~3H-TdR incorporation assay was used to determine proliferation of antigen-specific autologous T cells and enzyme-linked immunosorhent assay (ELISA)was used to examine concentrations of IFN-\u03b3,IL-2,IL-12 and IL-10 in the supernatants of mixed lym- phocytes reaction.In addition,the number of IFN-\u03b3-preducing antigen-specific autologous T cells were measured by enzyme-linked immunospot(ELISPOT)assay.Results B7-H1 is up-regulated on mDC from patients infected by hepatitis B virus in contrast to health subjects(7.88\u00b11.40 vs 0.35\u00b10.07,P<0.05)and its receptor PD-1 is also elevated on T cells in patients(20.40\u00b13.92 vs 5.95\u00b10.55,P<0.05).Moreover,the level of B7-H1 and PD-1 expression is positively correlated with the level of ALT.Blockade of signal pathway can improve the pro- liferation of antigen-specific autologous T cells stimulated by HBcAg-pulsed MoDC and production of type\u2160cyto- kines released by T cells.Moreover,blockade of B7-H1 also can improve the frequency of IFN-\u03b3producting anti- gen specific T cells.Conclusion Up-regulation of B7-H1 and PD-1 on mDC and T cells from patients with chron- ic hepatitis B virus infection impaired the immune function of HBV-specifie T lymphocytes.Blocking B7-H1/PD-1 interactions can revitalize the dysfunctional virus specific T cell repertoire.",
        "keywords": [
            "Costimulatory molecule",
            "B7-H1",
            "T lymphocytes",
            "Chronic hepatitis B"
        ],
        "authors": [
            {
                "name": "CHEN Liang-en",
                "org": ". Research Center of Biological Therapy,Beijing 302 Hospital,Beijing ,China"
            },
            {
                "name": "CHEN Wei-wei",
                "org": ". Research Center of Biological Therapy,Beijing 302 Hospital,Beijing ,China"
            },
            {
                "name": "FU Bao-yun",
                "org": ". Research Center of Biological Therapy,Beijing 302 Hospital,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". Research Center of Biological Therapy,Beijing 302 Hospital,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Microbiology and Immunology",
        "year": 2007
    },
    "Cj8uiA5Y": {
        "id": "Cj8uiA5Y",
        "title": "Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B.",
        "abstract": "CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B (CHB). One hundred twenty-one patients were enrolled, including 16 patients with acute hepatitis B, 76 with CHB, and 29 with chronic severe hepatitis B. We demonstrated that in chronic severe hepatitis B patients, the frequencies of CD4+CD25+ Treg in both PBMC and liver-infiltrating lymphocytes were significantly increased and there was a dramatic increase of FoxP3(+)-cell and inflammatory cell infiltration in the liver compared with healthy controls. In CHB patients, circulating CD4+CD25+ Treg frequency significantly correlates with serum viral load. In acute hepatitis B patients, circulating CD4+CD25+ Treg frequency was initially low and with time, the profile reversed to exhibit an increased number of circulating Treg in the convalescent phase and restored to normal levels upon resolution. In PBMC taken from infected patients, depletion of CD4+CD25+ Treg led to an increase of IFN-gamma production by HBV-Ag-stimulated PBMC. In addition, CD4+CD25+ Treg were capable of suppressing proliferation of autologous PBMC mediated by HBV Ags, which probably reflects the generation of HBV-Ag-specific Treg in circulation and in the liver of HBV-infected patients. Together, our findings suggest that CD4+CD25+ Treg play an active role not only in modulating effectors of immune response to HBV infection, but also in influencing the disease prognosis in patients with hepatitis B.",
        "keywords": [],
        "authors": [
            {
                "name": "Dongping Xu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hui Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Chunbao Zhou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zhengsheng Zou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "JingMin Zhao",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Bin Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ming Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Xilai Ding",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "ZiRong Tang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "YangXin Fu",
                "org": "University of Chicago(University of Chicago),Chicago,United States"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Journal of immunology (Baltimore, Md. : 1950)",
        "year": 2006
    },
    "HxFbMQUY": {
        "id": "HxFbMQUY",
        "title": "Liver: How can acute-on-chronic liver failure be accurately identified?",
        "abstract": "",
        "keywords": [
            "hepatology",
            "nature",
            "gastroenterology",
            "and"
        ],
        "authors": [
            {
                "name": "fusheng wang",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            }
        ],
        "venue": "Nature Reviews Gastroenterology & Hepatology",
        "year": 2013
    },
    "HbraOL5I": {
        "id": "HbraOL5I",
        "title": "Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases.",
        "abstract": "Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liver, thereby attenuating inflammatory injury and reducing hepatocyte apoptosis. In addition, MSCs play an important role in regressing liver fibrosis and in supporting the function, proliferation and differentiation of endogenous hepatocytes under appropriate conditions. Although remarkable progress has been achieved in basic and clinical MSC studies, optimal therapeutic regimens for the clinical application of MSCs, such as optimal doses, transplantation routine and interval period for transplantation, need to be elucidated in detail. Furthermore, the long-term safety and therapeutic efficacy of MSC transplantation should be evaluated in future clinical trials. This review summarizes our current understanding of the immunomodulatory effects of MSC therapies on human liver diseases.",
        "keywords": [
            "CMI",
            " Chinese Society of Immunology",
            " University of Science and Technology of China",
            " immunology",
            " cellular immunology",
            " molecular immunology",
            " innate immunity",
            " adaptive immunity",
            " clinical immunology",
            " comparative immunology",
            " immune receptors",
            " immunobiology",
            " immunogenetics",
            " immunological techniques",
            " immunopathology",
            " immunopharmacology",
            " infection immunology",
            " neuroimmunology",
            " transplantation",
            " tumor immunology",
            " veterinary immunology"
        ],
        "authors": [
            {
                "name": "Lin Hu",
                "org": "Liver Disease Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China."
            },
            {
                "name": "Xu Ruonan",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Chen Liming",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Cellular & molecular immunology",
        "year": 2011
    },
    "YYsmB1tL": {
        "id": "YYsmB1tL",
        "title": "Safety of the treatment with umbilical cord mesenchymal stem cells for chronic HIV infection",
        "abstract": "Objective To evaluate the safety and adverse reactions of the treatment with umbilical cord mesenchymal stem cells(UC-MSC) for chronic HIV infection. Methods Thirty chronic HIV-infected patients,who were treated in 302 hospital of PLA,were enrolled in this study. Individual patient was infused intravenously with 3\u00d7107 UC-MSC at 1 month interval for 3 times. Peripheral blood was collected before treatment and at week 1,2,4,8,12,24 and 48 of treatment for the detection of blood routine,liver function and renal function. Results Except that a small part of the patients had a slight fever after the first infusion of UC-MSC,no other adverse reactions were found. No significant differences in liver and renal function and blood routine were found before and after treatment. Conclusion The treatment with UC-MSC for chronic HIV-infected patients is safe. It provides an evidence for clinical treatment and the study of mechanisms.",
        "keywords": [
            "stem cells",
            "acquired immunodeficiency syndrome",
            "treatment outcome",
            "HIV"
        ],
        "authors": [
            {
                "name": "JIN Lei",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Zheng",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Si-yu",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "XU Ruo-nan",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-Sheng",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2010
    },
    "qN0JwHaZ": {
        "id": "qN0JwHaZ",
        "title": "Decreased numbers and impaired function of circulating dendritic cell subsets in patients with chronic hepatitis B infection (R2).",
        "abstract": "To investigate the frequencies, numbers and function of circulating dendritic cell (DC) subsets in patients with hepatitis B virus (HBV) infection, we assayed the circulating precursor DC subsets (including pDC1 and pDC2) and their ability in patients at various stages of HBV infection in vitro.Circulating pDC1 and pDC2 frequencies in peripheral blood mononuclear cells (PBMC) were analyzed by flow cytometric analysis. Costimulatory molecule expression and allostimulatory mixed lymphocyte reaction (AMLR) of DC1, cultured from PBMC in vitro, were detected in patients with chronic hepatitis B (CHB). On behalf of pDC2, interferon (IFN)-alpha production of PBMC was determined by the ELISA method in HBV-infected patients.The number of circulating pDC1 decreased only in patients with liver cirrhosis (LC) compared with that in normal controls. However, pDC2 numbers decreased in both CHB and LC patients. DC1 from CHB patients showed lower expression of costimulatory molecules CD80, CD86 and impaired allostimulatory mixed lymphocyte reaction (AMLR) compared with those in normal controls. The ability of PBMC to secrete IFN-alpha also decreased significantly in patients with chronic HBV infection.Our results suggest that patients with chronic HBV infection have a significantly lower expression of costimulatory molecules and impaired AMLR of pDC1, as well as decreased number and impaired function of circulating pDC2, which may be partially related to HBV disease progression in these patients.",
        "keywords": [
            "chronic hepatitis b",
            "dendritic cells",
            "liver cirrhosis",
            "subsets"
        ],
        "authors": [
            {
                "name": "XUE-ZHANG DUAN",
                "org": ""
            },
            {
                "name": "HUI ZHUANG",
                "org": ""
            },
            {
                "name": "MIN WANG",
                "org": ""
            },
            {
                "name": "HAN-WEI LI",
                "org": ""
            },
            {
                "name": "JING-CHAO LIU",
                "org": ""
            },
            {
                "name": "FU-SHENG WANG",
                "org": ""
            }
        ],
        "venue": "Journal of gastroenterology and hepatology",
        "year": 2005
    },
    "bqJWylSH": {
        "id": "bqJWylSH",
        "title": "The decrease of regulatory T cells correlates with excessive activation and apoptosis of CD8<sup>+</sup>T cells in HIV-1-infected typical progressors, but not in long-term non-progressors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yanmei Jiao",
                "org": ""
            },
            {
                "name": "JunLiang Fu",
                "org": ""
            },
            {
                "name": "Shaojun Xing",
                "org": ""
            },
            {
                "name": "Baoyun Fu",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Xicheng Wang",
                "org": ""
            },
            {
                "name": "Jiyuan Zhang",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Fubiao Kang",
                "org": ""
            },
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Immunology",
        "year": 2009
    },
    "c7wrfEL0": {
        "id": "c7wrfEL0",
        "title": "Host immunity influences disease progression and antiviral efficacy in humans infected with hepatitis B virus.",
        "abstract": "Hepatitis B virus (HBV) infection can lead to several severe liver diseases, including hepatitis, cirrhosis and hepatocellular carcinoma, although the underlying mechanisms responsible for the clinical outcome have not been well characterized. In this review, we retrospectively examine the history of immunological responses to HBV infection and summarize the current understanding of innate and adaptive immunity in the context of HBV-associated liver disease. Recent data indicate that the interaction between HBV and the host immune response not only substantially drives disease progression, but also significantly influences antiviral efficacy in HBV-infected individuals. Advances in the field have provided insight into the immunopathology of HBV infection. Based on the characteristics of host immune responses in patients with HBV infection, a 'climbing slope hypothesis' is proposed to suggest that therapeutic strategies aimed at modulating the immune activity of the host may represent a complementary approach to antiviral drug treatment for the management of chronically HBV-infected patients.",
        "keywords": [],
        "authors": [
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            }
        ],
        "venue": "Expert review of gastroenterology & hepatology",
        "year": 2009
    },
    "bVaCwFqk": {
        "id": "bVaCwFqk",
        "title": "Viral suppression correlates with dendritic cell restoration in chronic hepatitis B patients with autologous cytokine-induced killer cell transfusion.",
        "abstract": "Myeloid and plasmacytoid dendritic cells (mDCs, pDCs) are functionally impaired in patients with chronic hepatitis B (CHB). Adoptive immunotherapy can suppress hepatitis B virus (HBV) replication in CHB patients, but whether it can restore the functionality of mDCs and pDCs remains unknown.Autologous cytokine-induced killer (CIK) cells obtained from 14 CHB patients were transfused back to patients, case by case, to observe the effect of CIK-cell treatment on the frequency and functionality of mDCs and pDCs in CHB patients during a 24-week follow-up investigation.Seven virological responders exhibited a sustained decrease in HBV load after CIK-cell transfusion; another seven non-virological responders showed only sustained high levels of HBV load during the 24-week period following CIK-cell transfusion. The rate of hepatitis B e antigen loss or seroconversion was also higher in virological responders than in non-virological responders. Importantly, we found that the frequency and cytokine-producing capacity of mDCs and pDCs increased significantly in virological responders, but not in non-virological responders. In addition, these patients exhibited a close correlation between restoration DC subsets and a decrease in HBV DNA load, rather than a change in the alanine aminotransferase level.Cytokine-induced killer-cell treatment reduced HBV DNA load in some CHB patients; the efficiency at least partially correlates with the restoration of frequency and functionality of mDCs and pDCs.",
        "keywords": [
            "cytokine-induced killer cells",
            "myeloid dendritic cells",
            "adoptive therapy",
            "plasma cytoid dendritic cells",
            "hepatitis b virus",
            "chronic hepatitis b",
            "immune response"
        ],
        "authors": [
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Feng Shi",
                "org": ""
            },
            {
                "name": "Bin Zhang",
                "org": ""
            },
            {
                "name": "Zirong Tang",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Liming Chen",
                "org": ""
            },
            {
                "name": "Huifeng Wang",
                "org": ""
            },
            {
                "name": "Sheikh Mohammad Fazle Akbar",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Liver international : official journal of the International Association for the Study of the Liver",
        "year": 2009
    },
    "mSMXcmNR": {
        "id": "mSMXcmNR",
        "title": "Mechanism of homing and differentiation of mesenchymal stem cells in liver",
        "abstract": "Mesenchymal stem cells can restore the hepatic function by paracrine mechanism and differentiation into hepatic parenchymal cells,so transplantation of mesenchymal stem cells would be the important therapic method for liver disease.This review introduced the mechanism of homing and differentiation of mesenchymal stem cells in liver.",
        "keywords": [
            "Differentiation",
            "Mesenchymal stem cells",
            "Homing"
        ],
        "authors": [
            {
                "name": "LIN Hu",
                "org": "Sixth Department of Infectious Diseases,the 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CHEN Liming",
                "org": "Sixth Department of Infectious Diseases,the 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YE Wenhua",
                "org": "Sixth Department of Infectious Diseases,the 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "SHI Ming",
                "org": "Sixth Department of Infectious Diseases,the 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fusheng",
                "org": "Sixth Department of Infectious Diseases,the 302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Gastroenterology and Hepatology",
        "year": 2010
    },
    "f9S5HsL5": {
        "id": "f9S5HsL5",
        "title": "PD-1 and PD-L1 upregulation promotes CD8(+) T-cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients.",
        "abstract": "Programmed death 1 (PD-1) and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of cytotoxic CD8(+) T lymphocytes, the main effector cells in hepatocellular carcinoma (HCC) patients, are not well defined. In this study, we characterized circulating and intratumor PD-1/PD-L1 expression and analyzed their association with disease progression in a cohort of hepatitis B virus-infected patients, including 56 with HCC, 20 with liver cirrhosis (LC) and 20 healthy controls (HC). The frequency of circulating PD-1(+) CD8(+) T cells increased with disease progression from LC to HCC patients versus HC. Furthermore, tumor-infiltrating effector CD8(+) T cells showed a drastic increase in PD-1 expression. These increases in circulating and intratumor PD-1(+) CD8(+) T cells could predict poorer disease progression and postoperative recurrence. Immunohistochemical staining showed that PD-L1 expressing hepatoma cells and apoptotic infiltrating CD8(+) T cells were both enriched in tumor sections. In vitro, CD8(+) T cells induced PD-L1 expression on hepatoma cells in an IFN-\u03b3-dependent manner, which in turn promoted CD8(+) T cells apoptosis, and blocking PD-L1 reversed this effect. Therefore, this study extends our knowledge of the role of the PD-1/PD-L1 pathway in tumor evasion and provides evidence for a new therapeutic target in HCC patients.",
        "keywords": [
            "pd 1",
            "apoptosis"
        ],
        "authors": [
            {
                "name": "Shi Feng",
                "org": "Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, China."
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Zeng Zhen",
                "org": ""
            },
            {
                "name": "Qi Rui-Zhao",
                "org": ""
            },
            {
                "name": "Liu Zhen-Wen",
                "org": ""
            },
            {
                "name": "Zhang Ji-Yuan",
                "org": ""
            },
            {
                "name": "Yang Yong-Ping",
                "org": ""
            },
            {
                "name": "Tien Po",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "International journal of cancer. Journal international du cancer",
        "year": 2011
    },
    "d2MUYZX3": {
        "id": "d2MUYZX3",
        "title": "Reference ranges of peripheral blood lymphocyte subset percentages in hepatitis B virus-infected Chinese population",
        "abstract": "Objective To investigate region-specific reference ranges of peripheral blood lymphocyte subset percentages in he-patitis B virus(HBV)-infected Chinese population.Methods Flow cytometry was used to detect the percentages of peripheral blood lymphocyte subsets in 2846 HBV-infected subjects and 117 healthy subjects in 302 Hospital of PLA from 2001 to 2009.The refe-rence ranges of peripheral blood lymphocyte subset percentages in healthy and HBV-infected Chinese popula-tion were investigated.Results The reference ranges of the percentages of peripheral blood lymphocyte subsets including CD3+ T lymphocytes,CD3+CD4+ T lymphocytes,CD3+CD8+ T lymphocytes,CD4+/CD8+ ratio,CD3-CD19+ B cells,CD3-CD16+CD56+ natural killer(NK) cells and CD3+CD16+CD56+ NKT cells were defined in healthy adults and HBV-infected patients with acute hepatitis B,chronic hepatitis B(CHB),liver failure and liver cirrhosis(aged from 16 to 60 years old).It was found that the percentages of peripheral CD4+ T lymphocytes sig-nificantly increased,and NK cells and NKT cells significantly decreased in HBV-infected adult patients as compared with healthy adults.Further correlation analysis indicated that the age of all the subjects was slightly positively associated with the percentages of pe-ripheral CD4+ T lymphocytes,CD4/CD8 ratio,NK cells and NKT cells,but slightly negatively associated with CD8+ T lymphocytes and CD19+ B cells.Conclusions Through long-term and large-sample investigation,the region-specific reference ranges of peripheral blood lymphocyte subset percentages in HBV-infected adult Chinese patients are proposed.They will be helpful for the evaluation of immune status of the HBV-infected subjects in clinic.",
        "keywords": [
            "HBV",
            "reference ranges",
            "lymphocyte subsets"
        ],
        "authors": [
            {
                "name": "ZHANG Zheng",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FU Jun-liang",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHOU Chun-bao",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "JIN Lei",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Qing-hong",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "* Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "juNzgoc2": {
        "id": "juNzgoc2",
        "title": "Antiviral effect and influence on lymphocyte and dendritic cell of autologous cytokine-in-duced killer cells in patients with liver cirrhosis caused by chornic HBV infection",
        "abstract": "Objective:to observe the antiviral effect and influence on lymphocyte and dendritic cell(DC) of autologous cytokine-induced killer cells(CIK) in patient with liver cirrhosis caused by chornic HBV infection.Methods:33 patients with liver cirrhosis caused by HBV chronic infection were treated with CIK.The quantity of lymphocyte subset,mDC and pDC were detected by flow cytometry before and after CIK treatment.The markers of virology and the adverse seaction were also observed.Results:After treatment,HBV DNA in 12 patients couldn\u2032t be detected.The total effective power was 51.5%.HBeAg in 10 patients turned to negative in 14 patients who were positive in HBeAg,among them 5 patients appeared HBeAb conversion. CD8+ T lymphocyte,NKT cell increased in ineffective patients after CIK transfused back,but all of the CD3+,CD4+,CD8+ T lymphocyte and NKT cell increased in effective patients.Besides,the quantity of mDC\u3001 pDC also increased than pre treatment in effective patients.Conclusion:CIK has some antivirol effect in patients with liver cirrhosis caused by chronic HBV infection.Immune cells increase after CIK treatment.",
        "keywords": [
            "dendritic cell",
            "lymphocytes",
            "liver cirrhosis",
            "killer cells"
        ],
        "authors": [
            {
                "name": "SU Hai-bin",
                "org": "PLA 302th Hospital,Beijing ,China 1.Thirteenth Department of Infectious Disease"
            },
            {
                "name": "SHI Ming",
                "org": "Biology Therapy Research Center of Infectious Disease Institute"
            },
            {
                "name": "ZHANG Bing",
                "org": "Biology Therapy Research Center of Infectious Disease Institute"
            },
            {
                "name": "TANG Zi-rong",
                "org": "Biology Therapy Research Center of Infectious Disease Institute"
            },
            {
                "name": "LI Han-wei",
                "org": "PLA 302th Hospital,Beijing ,China 1.Thirteenth Department of Infectious Disease"
            },
            {
                "name": "LEI Zhou-yun",
                "org": "Biology Therapy Research Center of Infectious Disease Institute"
            },
            {
                "name": "WANG Hui-fen",
                "org": "PLA 302th Hospital,Beijing ,China 1.Thirteenth Department of Infectious Disease"
            },
            {
                "name": "WANG Fusheng",
                "org": "Biology Therapy Research Center of Infectious Disease Institute"
            }
        ],
        "venue": "Academic Journal of PLA Postgraduate Medical School",
        "year": 2007
    },
    "Gbq8z75q": {
        "id": "Gbq8z75q",
        "title": "Growth inhibition of human hepatocellular carcinoma xenograft in nude mice by combined treatment with human cytokine-induced killer cells and chemotherapy]",
        "abstract": "To compare the inhibitory effects of cytokine-induced killer (CIK) cells alone, chemotherapeutic drug alone, and CIK cells combined with chemotherapeutic drug on the growth of hepatocellular carcinoma (HCC) cells transplanted in nude mice.Peripheral blood mononuclear cells (PBMC) collected from five healthy donors by blood cell separator were incubated in vitro to induce CIK cells in the presence of interferon-gamma (IFN-gamma), IL-2 and anti-CD3 monoclonal antibody (mAb). The phenotype of CIK cells was characterized by flow cytometric analysis. BEL-7402 HCC cells were inoculated subcutaneously to nude mice. On day 5, at the inoculation site were injected normal saline (group 1), CIK cells (3 x 10(7) and 6 x 10(7), group 2 and 3), mitomycin-C (MMC 80 microg in 0.2 ml, group 4), and CIK cells combined with MMC (group 5), respectively.The percentage of CD3(+), CD3(+)CD8(+), CD3(+)CD56(+), CD25(+) cells increased from 64.0%, 28.0%, 7.8%, and 9.1% to 94.7%, 67.7%, 61.3%, and 84.0% respectively after cytokine induction. The percentage of CD3(+) and CD3(+)CD8(+) cells remained at high levels during incubation period, but that of CD25(+) and CD3(+)CD56(+) cells peaked respectively on day 7 and 13 and then declined. During the 90-day observation, the tumor formation rates were 100%, 70.0%, 80.0%, 70.0% and 66.7%; and the mouse survival rates were 10.0%, 60.0%, 40.0%, 50.0% and 75.0%, respectively from group 1 to group 5. Compared to the other groups, in the combined therapy group of mice, not only the tumor grew slowly and but also showed more marked tissue necrosis.The growth inhibitory effect on human HCC transplanted in nude mice of combined CIK cells and MMC treatment is more potent than that of CIK cells or MMC alone.",
        "keywords": [],
        "authors": [
            {
                "name": "Shi Ming",
                "org": "Division of Biological Engineering, Beijing Institute of Infectious Disease, the 302 Hospital of PLA, Beijing 100039, China."
            },
            {
                "name": "Yao Li",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            },
            {
                "name": "Lei Zhou-Yun",
                "org": ""
            },
            {
                "name": "Zhang Bing",
                "org": ""
            },
            {
                "name": "Li Wen-Liang",
                "org": ""
            },
            {
                "name": "Liu Jing-Chao",
                "org": ""
            },
            {
                "name": "Tang Zi-Rong",
                "org": ""
            },
            {
                "name": "Zhou Guang-de",
                "org": ""
            }
        ],
        "venue": "Zhonghua zhong liu za zhi [Chinese journal of oncology]",
        "year": 2004
    },
    "OpliMFyX": {
        "id": "OpliMFyX",
        "title": "Recent progress of tenofovir disoproxil fumarate for chronic hepatitis B",
        "abstract": "The nucleoside/nucleotide analogues have been used widely in the treatment of chronic hepatitis B(CHB).Teno-fovir disoproxil fumarate(TDF),a nucleotide analogue and potent inhibitor of HBV polymerase,shows superior efficacy in viral suppres-sion and low drug tolerance in CHB patients.The authors briefly summarize the recent progress of in vitro and in vivo studies of TDF and the prospect of its clinical application.",
        "keywords": [
            "tenofovir disoproxil fumarate",
            "liver cirrhosis",
            "antiviral agents",
            "nucleosides"
        ],
        "authors": [
            {
                "name": "WANG Lu-jun",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Ji-yuan",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FENG Guo-hua",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": " Liver Disease Research Center for Biological Therapy,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "7htLdR8s": {
        "id": "7htLdR8s",
        "title": "Establishment and application of hospital protection system for emerging infectious diseases",
        "abstract": "To establish a standardized hospital protection system for the prevention of nosocomial infection of emerging infectious diseases is an important means for the control of the epidemic.According to clinical experience,the authors summarize the work processes and regulations established and implemented in the control and treatment of severe acute respiratory syndrome and influenza A(H1N1),and based on the clinical practice,discuss the role of the hospital protection system in enhancing the establishment and implementation of scientific epidemic protection system and protecting the hospital from being an infection source.",
        "keywords": [
            "communicable diseases",
            "emerging",
            "special",
            "occupational health",
            "hospitals"
        ],
        "authors": [
            {
                "name": "NIE Wei-min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Xin",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WEN Cui-rong",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Li-jun",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "SHI Jian-fei",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "nBRAh1Xc": {
        "id": "nBRAh1Xc",
        "title": "Cutting edge: programmed death-1 up-regulation is involved in the attrition of cytomegalovirus-specific CD8+ T cells in acute self-limited hepatitis B virus infection.",
        "abstract": "Attrition of heterologous virus-specific CD8(+) T cells has been demonstrated in murine viral infection; however, little is known regarding this phenomenon in human viral infections. In this study, we observed that CMV-specific CD8(+) T cells displayed numerical decline and functional impairment in the early phase of acute infection, whereas programmed death-1 (PD-1) expression was significantly up-regulated by these CMV-specific CD8(+) T cells. This early PD-1 up-regulation was found to be closely associated with the increased apoptotic sensitivity of CMV-specific CD8(+) T cells. The in vitro addition of anti-PD-1 further enhanced the spontaneous apoptosis of CMV-specific CD8(+) T cells; however, blockade of the PD-1-mediated pathway with anti-PD-L1 significantly restored the CMV-specific CD8(+) T cell proliferation and IFN-gamma production. Thus, PD-1 plays a crucial role in the attrition of CMV-specific CD8(+) T cells in acute hepatitis B virus infection, which in turn, influences the preexisting homeostatic virus-specific CD8(+) T cell pool.",
        "keywords": [],
        "authors": [
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Bo Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "ShuYe Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Chunbao Zhou",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Journal of immunology (Baltimore, Md. : 1950)",
        "year": 2008
    },
    "hwIelcqG": {
        "id": "hwIelcqG",
        "title": "Autologous cytokine-induced killer cell therapy in clinical trial phase I is safe in patients with primary hepatocellular carcinoma.",
        "abstract": "To investigate the influence of autologous cytokine-induced killer (CIK) cells on the phenotypes of CIK effector cells, peripheral T lymphocyte subsets and dendritic cell subsets in patients with primary hepatocellular carcinoma (HCC).Peripheral blood mononuclear cells (PBMC) were collected by a blood cell separator from 13 patients with HCC, then expanded by priming them with interferon-gamma (IFN-gamma) followed by monoclonal antibody (mAb) against CD3 and interleukin-2 (IL-2) the next day. The phenotypic patterns of CIK cells were characterized by flow cytometry on d 0, 4, 7, 10, 13 and 15 of incubation, respectively. Then, 5 mL of venous blood was obtained from HCC patients before or 8-10 d after CIK cells were transfused into patients to assess the influence of CIK cells on the percentages of effector cells, and proportions of DC1 or DC2 in peripheral blood by flow cytometry.After two weeks of in vitro incubation, the percentages of CD3(+)CD8(+), CD3(+)CD56(+), and CD25(+) cells increased significantly from 33.5+/-10.1%, 7.7+/-2.8%, and 12.3+/-4.5% to 36.6+/-9.0% (P<0.05), 18.9+/-6.9% (P<0.01), and 16.4+/-5.9% (P<0.05), respectively. However, the percentages of CD3(+)CD4(+) and NK cells had no significant difference. The percentages of CD3(+) and CD3(+)CD8(+) cells were kept at high levels during the whole incubation period, but those of CD25(+), and CD3(+)CD56(+) cells began to decrease on d 7 and 13, respectively. The proportions of type I dendritic cell (DC1) and type II dendritic cell (DC2) subsets increased from 0.59+/-0.23% and 0.26+/-0.12% before CIK cell therapy to 0.85+/-0.27% and 0.43+/-0.19% (all P<0.01) after CIK cell transfusion, respectively. The symptoms and characteristics of HCC patients were relieved without major side effects.Our results indicated that autologous CIK cells can efficiently improve the immunological status in HCC patients, and may provide a potent approach for HCC patients as the adoptive immunotherapy.",
        "keywords": [
            "clinical trial",
            "cell therapy",
            "monoclonal antibody",
            "peripheral blood mononuclear cell",
            "side effect",
            "flow cytometry"
        ],
        "authors": [
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Bing Zhang",
                "org": ""
            },
            {
                "name": "Zi-Rong Tang",
                "org": ""
            },
            {
                "name": "Zhou-Yun Lei",
                "org": ""
            },
            {
                "name": "Hui-Fen Wang",
                "org": ""
            },
            {
                "name": "Yong-Yi Feng",
                "org": ""
            },
            {
                "name": "Zhen-Ping Fan",
                "org": ""
            },
            {
                "name": "Dong-Ping Xu",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "World journal of gastroenterology : WJG",
        "year": 2004
    },
    "89BlsraR": {
        "id": "89BlsraR",
        "title": "Progress in Studies of Antiviral Therapy in Special Patient Groups with Hepatitis C",
        "abstract": "Antiviral therapy is the fundamental therapeutic measure for patients infectied with hepatitis C virus(HCV).Neverthe-less,there are various tough problems for some special patient groups to choose an optimal treatment.The therapeutic strategy for HCV in-fection patients with kidney disease,HIV coinfection,psychiatric illnesses,compensated and decompensated cirrhosis,after solid organ transplantation,and HIV-infected children,needs to be studied further.This review focused on the current understanding of antiviral therapy in special patients with hepatitis C so as to guide the clinical practice and advanced research in the field.",
        "keywords": [
            "Antiviral Therapy",
            "Hepatitis C"
        ],
        "authors": [
            {
                "name": "JIANG Tianjun",
                "org": "Chinese PLA Postgraduate Medical School,Beijing ;The Institute of Infectious Disease,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Jiyuan",
                "org": "The Institute of Infectious Disease,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fusheng",
                "org": "The Institute of Infectious Disease,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Clinical Medicine & Engineering",
        "year": 2010
    },
    "fr6i371E": {
        "id": "fr6i371E",
        "title": "B and T lymphocyte attenuator down-regulation by HIV-1 depends on type I interferon and contributes to T-cell hyperactivation.",
        "abstract": "Nonspecific T-cell hyperactivation is the main driving force for human immunodeficiency virus (HIV)-1 disease progression, but the reasons why the excess immune response is not properly shut off are poorly defined.Eighty-five HIV-1-infected individuals were enrolled to characterize B and T lymphocyte attenuator (BTLA) expression and function. Infection and blockade assays were used to dissect the factors that influenced BTLA signaling in vitro.BTLA expression on overall CD4(+) and CD8(+) T cells was progressively decreased in HIV-1 infection, which was directly correlated with disease progression and CD4(+) T-cell differentiation and activation. BTLA(+)CD4(+) T cells from HIV-1-infected patients also displayed an altered immune status, which was indicated by reduced expression of naive markers but increased activation and exhaustion markers. Cross-linking of BTLA can substantially decrease CD4(+) T-cell activation in vitro. This responsiveness of CD4(+) T cells to BTLA-mediated inhibitory signaling was further found to be impaired in HIV-1-infected patients. Furthermore, HIV-1 NL4-3 down-regulated BTLA expression on CD4(+) T cells dependent on plasmacytoid dendritic cell (pDC)-derived interferon (IFN)-\u03b1. Blockade of IFN-\u03b1 or depletion of pDCs prevents HIV-1-induced BTLA down-regulation.HIV-1 infection potentially impairs BTLA-mediated signaling dependent on pDC-derived IFN-\u03b1, which may contribute to broad T-cell hyperactivation induced by chronic HIV-1 infection.",
        "keywords": [],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Xiangsheng Xu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jiyun Lv",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "ShuYe Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lanlan Gu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Haiying Li",
                "org": "Capital University of Medical Science(Capital University of Medical Science),,China"
            },
            {
                "name": "Min Zhao",
                "org": "Capital University of Medical Science(Capital University of Medical Science),,China"
            },
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hao Wu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lishan Su",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "YangXin Fu",
                "org": "Institute of Biophysics Chinese Academy of Sciences(Chinese Academy of Sciences,Institute of Biophysics),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "The Journal of infectious diseases",
        "year": 2011
    },
    "85WGm3Jt": {
        "id": "85WGm3Jt",
        "title": "Immunological markers in patients with influenza A(H1N1)",
        "abstract": "Objective To investigate the features of immunological markers in patients with influenza A(H1N1).Methods Immunological markers of 87 patients with influenza A(H1N1) in acute phase and recovery phase were compared and analyzed statistically.Results In acute phase,total lymphocyte,CD4+ T lymphocyte,CD8+ T lymphocyte and B lymphocyte counts decreased obviously.In recovery phase,all the markers increased obviously,and CH50 maintained a high level during the course of illness.Conclusion Cellmediated immunity plays an important role in the course of illness in the patients with influenza A(H1N1).",
        "keywords": [
            "complement",
            "H1N1 subtype",
            "influenza A virus",
            "T cell subgroup"
        ],
        "authors": [
            {
                "name": "TU Bo",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "JIANG Tian-jun",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YAN Hui-ying",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "QIU Bo",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "QIN En-qiang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "FAN Rong",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHOU Zhi-ping",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2010
    },
    "lWTV7rZQ": {
        "id": "lWTV7rZQ",
        "title": "Serial analyses of viral levels and immunocytes during in vitro incubation of peripheral blood mononuclear cells from HIV-infected individuals]",
        "abstract": "To investigate the dynamic changes of viral loads and immunocytes during the in vitro culture of peripheral blood mononuclear cells (PBMC) from HIV carriers.The PBMCs from 14 HIV-infected individuals and 6 healthy persons were incubated in serum-free AIM-V medium containing cocktail cytokines. The phenotype of CD3, CD4, CD8, CD3CD56 and CD25 was identified by flow cytometric analysis every two days. The production of cytokines in the supernatants, including IL-1alpha, IL-12, TNF-alpha and IL-10 was measured by ELISA. The supernatant HIV-1 RNA load was also determined by Real-time fluorescent PCR.During a 21-day incubation period, The PBMCs multiplied approximately 60.7-fold and 16.8-fold respectively in the healthy controls and 7 out of the 14 HIV-infected subjects, however failed to multiply in the remaining 7 HIV-infected subjects. The expanded cells were phenotypically shown a heterogeneous cellular population with 23.3%-35% for CD3(+)CD4(+) T cells and 58.7%-72% for CD3(+)CD8(+) T cells, and approximate 17% CD3(+)CD56(+) cells at 16-day incubation for HIV-infected cases. HIV-1-positive PBMCs were found to produce an elevated ratios (value range 6.01 - 48.04) of IL-12:IL-10 compared to healthy individuals (6.65 - 10.2) at 16-day incubation. Furthermore, serial analyses of HIV-1 RNA levels showed an inverted V type dynamic change during 16 day in vitro incubation period.In vitro expansion of functional immunocytes of HIV-1 carrier origin is feasible and may facilitate the autologous antiviral immune therapy for HIV-infected patients.",
        "keywords": [
            "cell culture",
            "lymphocytes",
            "hiv-1"
        ],
        "authors": [
            {
                "name": "Zhang Zheng",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China."
            },
            {
                "name": "Zhao Min",
                "org": ""
            },
            {
                "name": "Nie Wei-min",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Jiang Tian-jun",
                "org": ""
            },
            {
                "name": "Tang Zi-rong",
                "org": ""
            },
            {
                "name": "Wang Jian",
                "org": ""
            },
            {
                "name": "Zhang Lin-qi",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2005
    },
    "HuA7Gqqm": {
        "id": "HuA7Gqqm",
        "title": "Immunopathogenesis and prognostic immune markers of chronic hepatitis B virus infection.",
        "abstract": "Host immune responses induced by hepatitis B virus (HBV) infection not only substantially drive disease progression, but also significantly influence efficacy of antiviral treatments in HBV-infected individuals. Therefore, it is important to fully understand the course of immune pathogenesis and to find efficient immunological markers that can predict the disease progression of chronic HBV infection. This review introduces the current progress in clinical immunology and analyzes the mechanisms of antiviral effects and liver injury, which are induced by both innate and adaptive immune responses. The recently identified immunological markers indicated to be closely correlated with disease progression and antiviral efficacy during HBV infection are also summarized. Careful monitoring of these immune markers may help physicians to make decisions on when to begin or withdraw antiviral drugs, or to formulate the prognosis of acute-on-chronic liver failure (ACLF) patients in the clinic. Finally, this review highlights some novel therapeutic strategies to modulate host immunity that have been proposed to sustain antiviral control of chronic HBV infection, as well as the challenges that we are presently facing in the field.",
        "keywords": [
            "hepatitis b",
            "immunology",
            "liver immunobiology",
            "viral hepatitis"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jiyuan Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lifeng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Journal of gastroenterology and hepatology",
        "year": 2012
    },
    "GaZeF8Cs": {
        "id": "GaZeF8Cs",
        "title": "Progress of non-invasive methods for the assessment of liver fibrosis",
        "abstract": "Accurate staging of liver fibrosis is important for guiding the treatment of liver diseases.Non-invasive diagnosis may help to avoid or reduce the need for liver biopsy and would be an important method for the assessment of liver fibrosis.The authors evaluate the clinical data,serological markers and imaging techniques in the assessment of liver fibrosis,and introduce the progress of non-invasive methods for the improved diagnosis of liver fibrosis and cirrhosis.",
        "keywords": [
            "biopsy",
            "liver cirrhosis",
            "biological markers",
            "fibrosis"
        ],
        "authors": [
            {
                "name": "LIN Hu",
                "org": "* Postgraduate Team of PLA Postgraduate Medical School,Beijing ,China"
            },
            {
                "name": "CHEN Li-ming",
                "org": "* Postgraduate Team of PLA Postgraduate Medical School,Beijing ,China"
            },
            {
                "name": "YE Wen-hua",
                "org": "* Postgraduate Team of PLA Postgraduate Medical School,Beijing ,China"
            },
            {
                "name": "LI Yuan-yuan",
                "org": "* Postgraduate Team of PLA Postgraduate Medical School,Beijing ,China"
            },
            {
                "name": "GENG Hua",
                "org": "* Postgraduate Team of PLA Postgraduate Medical School,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "* Postgraduate Team of PLA Postgraduate Medical School,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2010
    },
    "L8h5H78x": {
        "id": "L8h5H78x",
        "title": "Characterization and clinical significance of PD-1 expression on HBV epitope-specific CD8~+ T cells in patients with acute self-limited hepatitis B",
        "abstract": "Objective Programmed cell death 1(PD-1)up-regulation can impair virus-specific CD8+ T-cell responses during chronic viral infection.Whether PD-1 affects virus-specific CD8+ T cells in humans with acute viral infection and the mechanism of this effect,however,remain largely undefined.This study aimed to characterize the PD-1 expression during acute hepatitis B(AHB),and further address how the PD-1 regulates antiviral immunity in acute HBV infection.Methods HBV-specific CD8+ T cells in peripheral blood from 16 HLA-A2-positive AHB patients were quantitatively analyzed and PD-1 expression on HBV-specific CD8+ T cells were measured using flow cytometry.Intracellular IFN-\u03b3 staining was performed for analyses of the impact of PD-1 expression.Serum ALT levels,HBV markers and HBV-DNA levels were evaluated for each subject.Results All 16 AHB patients examined had multiple pentamer responses.PD-1 expression on HBV-specific CD8+ T cells was significantly up-regulated in the early phase of acute HBV infection.Blockade of PD-1 ligation enhances the amount of IFN-\u03b3 production by HBV-specific CD8+ T cells following 6-h stimulation with cognate peptide.Conclusion PD-1/PD-L1 pathway plays a role in the regulation of the function of HBV-specific CD8+ T cells at early phase of acute HBV infection and high PD-1 expression by HBV-specific CD8+ T cells appear to efficiently temper liver damage.",
        "keywords": [
            "Immune inhibitory pathway",
            "Cytotoxic T lymphocyte",
            "Acute hepatitis B"
        ],
        "authors": [
            {
                "name": "JIN Bo",
                "org": "Military Postgraduate Medical College,"
            },
            {
                "name": "ZHANG Zheng",
                "org": "302 Militory Hospital of China Beijing ,China"
            },
            {
                "name": "WANG Hui-Fen",
                "org": "302 Militory Hospital of China Beijing ,China"
            },
            {
                "name": "WANG Fu-Sheng",
                "org": "302 Militory Hospital of China Beijing ,China"
            }
        ],
        "venue": "Chinese Hepatology",
        "year": 2008
    },
    "V4mOGsxx": {
        "id": "V4mOGsxx",
        "title": "exhaustion in typical progressors, but not in long-term non-progressors",
        "abstract": "",
        "keywords": [
            "aids",
            "t-cell memory",
            "t-cell costimulation",
            "cytotoxic t lymphocyte",
            "programmed death 1"
        ],
        "authors": [
            {
                "name": "Ji-Yuan Zhang",
                "org": "Institute of Microbiology|Chinese Academy of Sciences"
            },
            {
                "name": "Xicheng Wang",
                "org": ""
            },
            {
                "name": "Jun-Liang Fu",
                "org": ""
            },
            {
                "name": "Jinxia Yao",
                "org": ""
            },
            {
                "name": "Yanmei Jiao",
                "org": ""
            },
            {
                "name": "Liangen Chen",
                "org": ""
            },
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Jianan Wei",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "George Fu Gao",
                "org": ""
            },
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "H4mYgBjj": {
        "id": "H4mYgBjj",
        "title": "The diagnosis and treatment of bilateral multifocal renal angiomyolipomas in patients with tuberous sclerosis",
        "abstract": "Objective To evaluate the diagnosis and treatment of bilateral multifocal renal angiomyolipomas in patients with tuberous sclerosis.Methods Three cases of bilateral multifocal renal angiomyolipomas accompanied by tuberous sclerosis were analyzed retrospectively.Results One case undergoing nephrectomy died 10 days later for multiple organ failure;two patients with renal angiomyolipomas were stable in 24-month follow-up.Conclusions Most patients of bilateral multifocal renal angiomyolipomas accompanied by tuberous sclerosis were symptom free,and the tumors seemed stable in size,can be treated conservatively with annual computerized tomography.Selective renal arterial embolization is the first choice of intervention,but should be reserved until symptoms develop.",
        "keywords": [
            "Hamartoma Tuberous sclerosis Kidney"
        ],
        "authors": [
            {
                "name": "LIU Shang-wen",
                "org": ".Department of Urology,The 303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "ZHOU Da-qing",
                "org": ".Department of Urology,The 303rd Hospital of PLA,Nanning ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": ".Department of Urology,The 303rd Hospital of PLA,Nanning ,China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2008
    },
    "utdDGMp0": {
        "id": "utdDGMp0",
        "title": "Characteristics and significance of peripheral blood Th17 cells and regulatory T cells in liver transplantation patients with acute rejection",
        "abstract": "Objective To investigate the characteristics of changes and clinical significance of Th17 cells and CD4+CD25+Foxp3+ regulatory T cells(Treg) in peripheral blood in liver transplant patients suffering from acute transplant rejection.Methods A total of 25 liver transplant patients admitted in 302 Hospital of People's Liberation Army from January to September 2011 underwent needle biopsy for the transplanted hepatic tissue.The patients were divided into two groups: acute rejection group(12 cases) and stable-graft group(13 cases).In addition,13 healthy people were enlisted in the study and regarded as control.Flow cytometric analysis was used to measure the proportion of Th17 cells and Treg cells in peripheral blood among CD4+ T cells,and to observe the relationship between change in Th17/Treg ratio and liver injury.Results The proportion of Th17/CD4+T in acute rejection group(3.50%\u00b10.86%) after transplantation was higher than that in the stable-graft group(2.10%\u00b10.52%) and control group(1.79%\u00b10.42%,P<0.01).There was no statistical difference in cell ratio between the stable-graft group and control group(P>0.05).The Treg/CD4+T cell ratio in the peripheral blood of the patients from acute rejection and stable-graft group(0.90%\u00b10.25% and 1.51%\u00b10.23%,respectively) were significantly lower than that of control group(2.57%\u00b10.79%,P<0.01),and that of acute rejection group was notably lower than that of stable-graft group(P<0.05).The Th17/Treg ratio in acute rejection group(4.20\u00b11.69) was significantly higher than that of stable-graft group(1.43\u00b10.47) and control group(0.75\u00b10.28,P<0.01),and that of stable-graft group was higher than that of control group(P<0.01).The ratio of Th17/Treg was positively correlated with alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and glutamate transaminase(GGT) levels(r=0.5023,P=0.0105;r=0.4561,P=0.0219;r=0.4393,P=0.0280;and r=0.5516,P=0.0043,respectively).Conclusions Th17/ Treg imbalance exists in liver transplant patients suffering from acute rejection,which may be related to liver injury to a certain degree.Furthermore,Th17/Treg imbalance may be involved at the onset and development of acute rejection after liver transplantation.",
        "keywords": [
            "regulatory",
            "liver transplantation",
            "t-lymphocytes",
            "graft rejection"
        ],
        "authors": [
            {
                "name": "REN Wei-guo",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "SHI Ming",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "LIU Zhen-wen",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "SUN Yan-ling",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "SUN Bai-jun",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "WANG Hong-bo",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "CHU Jing-ru",
                "org": "Liver Transplantation Research Center,"
            },
            {
                "name": "JIN Lei",
                "org": "Liver Disease Biological Treatment Center,Peking University 302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Liver Disease Biological Treatment Center,Peking University 302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2012
    },
    "VNV1yw1k": {
        "id": "VNV1yw1k",
        "title": "Prospective controlled trial of safety of human umbilical cord derived-mesenchymal stem cell transplantation in patients with decompensated liver cirrhosis]",
        "abstract": "To evaluate the safety of human umbilical cord derived-mesenchymal stem cell (UC-MSC) transplantation therapy in patients with decompensated liver cirrhosis.UC-MSCs were transplanted intravenously into patients with decompensated liver cirrhosis. Serum levels of glucose (GLU), total cholesterol (TC), blood urea nitrogen (BUN), alpha fetoprotein (AFP), white blood cells (WBC), and prothrombin activity (PA) were detected at different time points after UC-MSCs transplantation.Most UC-MSC transplanted patients experienced an improvement in quality of life, to varying degrees. With the exception of low-grade fever in a few patients, side effects and oncogenic events were rare (treatment group: 1/38 vs. control group: 1/16; P more than 0.05). The UC-MSCs transplantation showed no effect on GLU, TC, BUN, AFP, WBC, or PA.UC-MSCs transplantation in patients with decompensated liver cirrhosis is safe and may improve the patient's quality of life.",
        "keywords": [],
        "authors": [
            {
                "name": "Lin Hu",
                "org": "The Research Center For Biological Therapy, Beijing 302 Hospital, Beijing, China."
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Xu Ruo-nan",
                "org": ""
            },
            {
                "name": "Fu Jun-liang",
                "org": ""
            },
            {
                "name": "Geng Hua",
                "org": ""
            },
            {
                "name": "Li Yuan-yuan",
                "org": ""
            },
            {
                "name": "Yu Shuang-jie",
                "org": ""
            },
            {
                "name": "Chen Li-ming",
                "org": ""
            },
            {
                "name": "Lv Sa",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2012
    },
    "Ni5izhf2": {
        "id": "Ni5izhf2",
        "title": "Detection and the production mechanism of antinuclear antibodies (ANA) and anti-liver/kidney microsomal tpe 1 antibodies (anti-LKM1) in patients with chronic hepatitis C]",
        "abstract": "To investigate the prevalence of antinuclear antibodies (ANA) and anti-liver/ kidney microsomal type 1 antibodies (anti-LKM1) in patients with chronic hepatitis C (CHC)and to explore the mechanism of production of these autoantibodies.Serum samples were collected from 360 patients with CHC (case group), 69 patients with chronic hepatitis B (CHB) and 69 patients with autoimmune hepatitis (AIH) (control group). Serum ANA and anti-LKM1 were detected by indirect immunofluorescence (HF) technique and enzyme-linked immunosorbent assay (ELISA), respectively. Multi-factor analysis was performed to explore the correlations of the production of autoantibodies with some factors such as age, sex, viral loads, HCV genotype, biochemical parameters and clinical characteristics.Fifty-four (15%) of 360 patients infected with HCV were positive in autoantibodies. The prevalence of ANA and anti-LKM1 were 12.5% (45/360) and 2.5% (9/ 360), respectively. The positive rate of autoantibodies in patients with CHC was significantly higher than that in patients with CHB (15% vs 2.9%, P = 0.006), but significantly lower than that in patients with AIH (15% vs 47.9%, P < 0.001). Twenty-one (11.35%) of 185 male patients and 33 (18.86%) of 175 female patients were positive in autoantibodies, the difference in positive rate was significant (P < 0.05). HCV virus loads in the autoantibodies negative group were higher than that in the autoantibodies positive group (7.2 x 10(7) copies/L vs 1.23 x 10(7) copies/L, P < 0.05). There were not significant differences in age and genotype between the autoantibody positive group and the autoantibody negative group. The serum biochemical parameters of the autoantibody positive group were similar to those of the autoantibody negative group. The differences were not significant for the course of disease, clinical symptom, the incidence of cirrhosis between the autoantibody positive group and the autoantibody negative group. The prevalence of autoantibodies was not different for patients with or without interferon treatment (P > 0.05).Autoantibodies related to AIH can be detected in CHC patients; interferon may not induce the production of autoantibodies; it is very likely that HCV infection induces the autoimmune reaction and the production of autoantibodies.",
        "keywords": [],
        "authors": [
            {
                "name": "Bai Li",
                "org": "Department of Infectious Disease, Peking University First Hospital, Beijing 100034, China."
            },
            {
                "name": "Lu Hai-Ying",
                "org": ""
            },
            {
                "name": "Feng Zhen-Ru",
                "org": ""
            },
            {
                "name": "Yu Min",
                "org": ""
            },
            {
                "name": "Li Wen-Gang",
                "org": ""
            },
            {
                "name": "Gong Wei-Bo",
                "org": ""
            },
            {
                "name": "Zhao Nu-en-ji-ya",
                "org": ""
            },
            {
                "name": "Xu Xiao-Yuan",
                "org": ""
            }
        ],
        "venue": "Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology",
        "year": 2009
    },
    "qAGfYi46": {
        "id": "qAGfYi46",
        "title": "Skewed ratios between CD3(+) T cells and monocytes are associated with poor prognosis in patients with HBV-related acute-on-chronic liver failure.",
        "abstract": "Tempering of the innate immune response by T lymphocytes has been demonstrated to play a critical role in protecting animals from inflammation-induced death; however, its role in humans remains unknown. Patients with HBV-related acute-on-chronic liver failure (ACLF) share a striking similarity to the inflammatory response in septic shock where a hyperactive innate response is observed. The present study attempted to characterize the features of CD3(+) T cells and monocytes and evaluate their clinical implications in 55 patients with HBV-related ACLF, 30 patients with chronic hepatitis B (CHB) and 30 healthy controls (HC). We found that the ratio between circulating CD3(+) T cells and monocytes (T/M) was decreased in ACLF patients, due to decreased CD3 counts and increased monocyte counts compared with CHB and HC subjects. We also found that the T/M ratios were decreased from the early to the intermediate stage and reached the lowest value at the late stage in ACLF patients. Analyses with clinical parameters revealed that T/M ratios were negatively correlated with the Model for End-Stage Liver Disease Score and direct bilirubin, and positively correlated with prothrombin activity. Moreover, increased T/M ratios were observed in patients with good prognosis, but not in patients with a poor outcome; and ACLF patients who received liver transplantation exhibited an increased T/M ratio. Importantly, we found that programmed death-1 receptor (PD-1) was drastically upregulated on both CD4(+) T and CD8(+) T cells in ACLF, which at least in part contributed to the T-cell loss in these patients. Mechanically, the in vitro co-culture assay revealed that both CD4(+) T and CD8(+) T cells, as well as regulatory T cells, could inhibit TNF-\u03b1 secretion by monocytes. In addition, the TNF-\u03b1 levels in ACLF serum were negatively correlated with T/M ratios. In conclusion, our study identified the novel potential role of T/M ratio in predicting disease progression and provided novel evidences for further studies of the immunopathogenesis in ACLF.",
        "keywords": [
            "cd8 t cell",
            "innate immune response"
        ],
        "authors": [
            {
                "name": "Shi Feng",
                "org": "Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China."
            },
            {
                "name": "Zhang Ji-Yuan",
                "org": ""
            },
            {
                "name": "Zeng Zhen",
                "org": ""
            },
            {
                "name": "Tien Po",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Biochemical and biophysical research communications",
        "year": 2010
    },
    "rU0aKQcc": {
        "id": "rU0aKQcc",
        "title": "Characteristics of zoonoses,reasons of misdiagnosis and countermeasures",
        "abstract": "In recent years,about half of the emerging infectious diseases are zoonoses,which pose a serious threat to human health and economic development.Because of the change in environment and life style,zoonoses present with new features in the aspects of transmission chain,transmission mode and clinical manifestations and some zoonoses such as brucellosis,tsutsugamushi disease,cerebral toxoplasmosis,rabies and cryptosporidiosis are easily misdiagnosed.To reduce misdiagnosis,we should have a cor-rect understanding of the hosts and pathogens of zoonoses,have a general idea of the geographical environment and climate of the places in which zoonoses occur and various clinical manifestations of zoonoses,and emphasize the use of epidemiological data.",
        "keywords": [
            "communicable diseases",
            "disease reservoirs",
            "hemorrhagic fever with renal syndrome",
            "Rickettsia",
            "H5N1 subtype"
        ],
        "authors": [
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "XU Zhe",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2012
    },
    "7ricqKJu": {
        "id": "7ricqKJu",
        "title": "Studies on function of HBV antigen-pulsed dendritic cells from patients with HBV-associated hepatocellular carcinoma",
        "abstract": "Objective To investigate the characteristics of HBsAg and HBcAg in combination pulsed monocyte-derived DCs (MoDC) derived from patients with HBV-associated hepatocellular carcinoma (HCC). Methods MoDCs were generated from 20 HBV-associated HCC patients, and pulsed with recombinant human serum albumin (rHSA) as conDC (control DC), or pulsed with HBsAg and HBcAg in combination as scDC. Phenotypic patterns of MoDCs were characterized by flow cytometry, and the levels of cytokines released by MoDCs were analyzed by ELISA, and frequencies of IFN-\u03b3-producing antigen-specific autologous T cells were measured by Elispot assay. HBV-specific CD8 T cells proliferation was determined by pentamer staining. Results 1. The levels of MHC and costimulatory molecules expressed on scDC were significantly higher than those on immature MoDC (imaDC) in two groups, and the levels of MHC and costimulatory molecules expressed on imaDC, conDC and scDC in HBsAg+, anti-HBe+, anti-HBc+ patients (1-4-5 positive group) were significantly higher than those in HBsAg+, anti-HBc+ patients (1-5 positive group); 2. The levels of IL-12 and IL-10 produced by scDC were higher than those produced by imaDC and conDC in both groups, and the levels of IL-12 produced by imaDC, conDC and scDC in 1-4-5 positive group were higher than those in 1-5 positive group. 3. The frequencies of IFN-\u03b3-producing T cells induced by scDC were higher than those by conDC in 1-4-5 positive group. 4. scDCs from 4 cases of HLA-A2+ patients in 1-4-5 positive group could induce autologous T cells to generate HBVcore18-27-specific CD8 T cells. Conclusions HBsAg and HBcAg pulse in combination could substantially reverse the impaired function of MoDCs in HBV-associated HCC patients, and boost MoDC to induce HBV-specific T cells response, especially in HBsAg+, anti-HBe+ and anti-HBc+ patients.",
        "keywords": [
            "hepatocellular",
            "dendritic cells",
            "hepatitis b virus",
            "carcinoma"
        ],
        "authors": [
            {
                "name": "Chen Weiwei",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Shi Feng",
                "org": ""
            },
            {
                "name": "Xin Shaojie",
                "org": ""
            },
            {
                "name": "Wang Fusheng",
                "org": ""
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2007
    },
    "5pPkHngV": {
        "id": "5pPkHngV",
        "title": "Interleukin-17-producing CD4(+) T cells increase with severity of liver damage in patients with chronic hepatitis B.",
        "abstract": "Interleukin-17 (IL-17)-producing CD4(+) T cells (Th17)-mediated immune response has been demonstrated to play a critical role in inflammation-associated disease; however, its role in chronic hepatitis B virus (HBV) infection remains unknown. Here we characterized peripheral and intrahepatic Th17 cells and analyzed their association with liver injury in a cohort of HBV-infected patients including 66 with chronic hepatitis B (CHB), 23 with HBV-associated acute-on-chronic liver failure (ACLF), and 30 healthy subjects as controls. The frequency of circulating Th17 cells increased with disease progression from CHB (mean, 4.34%) to ACLF (mean, 5.62%) patients versus healthy controls (mean, 2.42%). Th17 cells were also found to be largely accumulated in the livers of CHB patients. The increases in circulating and intrahepatic Th17 cells positively correlated with plasma viral load, serum alanine aminotransferase levels, and histological activity index. In vitro, IL-17 can promote the activation of myeloid dendritic cells and monocytes and enhance the capacity to produce proinflammatory cytokines IL-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-23 in both CHB patients and healthy subjects. In addition, the concentration of serum Th17-associated cytokines was also increased in CHB and ACLF patients.Th17 cells are highly enriched in both peripheral blood and liver of CHB patients, and exhibit a potential to exacerbate liver damage during chronic HBV infection.",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Ji-Yuan",
                "org": "Research Center for Biological Therapy, Beijing, China."
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Lin Fang",
                "org": ""
            },
            {
                "name": "Zou Zheng-Sheng",
                "org": ""
            },
            {
                "name": "Xu Ruo-Nan",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Fu Jun-Liang",
                "org": ""
            },
            {
                "name": "Shi Feng",
                "org": ""
            },
            {
                "name": "Shi Ming",
                "org": ""
            },
            {
                "name": "Wang Hui-Fen",
                "org": ""
            },
            {
                "name": "Wang Fu-Sheng",
                "org": ""
            }
        ],
        "venue": "Hepatology (Baltimore, Md.)",
        "year": 2010
    },
    "fXHmQEhM": {
        "id": "fXHmQEhM",
        "title": "EFFECT OF B7-H1 ON T-CELL STIMULATING CAPACITY OF DENDRITIC CELLS IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION",
        "abstract": "Objective: To examine the expression of B7-homolog 1(B7-H1) on circulating myeloid dendritic cells(DCs) in patients with chronic hepatitis B virus(HBV) infection and explore its effect on T-cell stimulating capacity of DCs.Methods: The expression of B7-H1 on DCs isolated from forty-six patients with chronic HBV infection,including 11 immune tolerance patients and 35 immune activation patients,and 28 healthy individuals,was determined by FACS(fluorescence-activated cell sorter) gated on Lin1-CD11c+HLA-DR+ cells.(3H)-TdR incorporation assay was used to determine proliferation of heterologous T cells stimulated by DCs in mixed lymphocytes reaction(MLR).Concentrations of IFN-\u03b3,IL-2,IL12 and IL-10 in the mixed lymphocytes culture supernatants were examined by ELISA.Results: The positive expression rates in immune tolerance patients,and immune activation patients((2.21\u00b10.32) %,(7.88\u00b11.40)% respectively)were significantly higher than that in healthy subjects((0.35\u00b10.10)%,P<0.01).The proliferation of heterologous T cells and production of type 1 cytokine stimulated by DCs from patients were significantly decreased.Blockade of B7-H1 on DCs could restore poor T-cell stimulating capacity of DCs.Conclusion: Upregulation of B7-H1 on DCs in patients with hepatitis B virus infection leads to decrease in T-cell stimulating capacity of DCs.",
        "keywords": [
            "B7-H1",
            "chronic hepatitis B",
            "T lymphocytes",
            "dendritic cells"
        ],
        "authors": [
            {
                "name": "CHEN Liang-en",
                "org": "Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "LI Yong-gang",
                "org": "Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": "Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Institute of Radiation Medicine,Academy of Military Medical Sciences,Beijing ,China"
            }
        ],
        "venue": "Journal of Preventive Medicine of Chinese People's Liberation Army",
        "year": 2007
    },
    "xr4WS09B": {
        "id": "xr4WS09B",
        "title": "Are non\u2010traditional CD4+CD69+CD25\u2013 regulatory T cells involved in disease progression of human hepatocellular carcinoma?",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dongping xu",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Journal of Gastroenterology and Hepatology",
        "year": 2011
    },
    "OW6IvWN9": {
        "id": "OW6IvWN9",
        "title": "Interleukin-17-producing CD4<sup>+</sup>T cells increase with severity of liver damage in patients with chronic hepatitis B",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Ji-Yuan Zhang",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Fang Lin",
                "org": ""
            },
            {
                "name": "Zheng-Sheng Zou",
                "org": ""
            },
            {
                "name": "Ruo-Nan Xu",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Jun-Liang Fu",
                "org": ""
            },
            {
                "name": "Feng Shi",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Hui-Fen Wang",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Hepatology",
        "year": 2009
    },
    "DFPlgW4w": {
        "id": "DFPlgW4w",
        "title": "Characterization and clinical implication of peripheral monocyte-derived dendritic cells(DC1) and T lymphocyte subsets in patients with chronic hepatitis C",
        "abstract": "Objective To explore immunologic characteristics of DC1 and lymphocyte subsets in patients with chronic hepatitis C. Methods Eighteen patients with chronic hepatitis C and 18 healthy blood donors were enrolled in our study. DC1 was induced from peripheral blood mononuclear cells (PBMC) and surface markers of DC1 and lymphocytes subsets were detected by flow cytometry simultaneously. Biochemical parameters and HCV viral load were also recorded. Results A great number of DC1 were induced in vitro. Our data showed that fluorescence density of CD80, CD86, CD1a and HLA-DR expression on DC1 was significantly lower in patients with chronic hepatitis C than that in normal controls(14.82%\u00b113.32% vs 76.46%\u00b112.25%, 18.68%\u00b113.76% vs 84.38%\u00b19.72%, 6.33%\u00b14.98% vs 89.56%\u00b18.96%, 29.14%\u00b114.00% vs 92.47%\u00b19.34%, respectively, all P<0.001). We also found there was a significant increase in ratio and number of circulating CD4+ T lymphocyte subsets, and a decrease in CD8+ T cells and NK cells, which produced an increased ratio of CD4+ and CD8+ in the patient group compared with those in normal controls(all P<0.01). The number of CD16+56+NK cells in the patient group was less than that in normal controls. In addition, we found a negative association of HCV RNA level with DC1 numbers as well as the serum ALT level and DC1 numbers in patients with chronic hepatitis C. Furthermore, we analyzed 3 patients who were treated with IFN-\u03b1 and found that the peripheral DC1 production increased. Conclusions The decreased DC1 function may be one of the major reasons for continuous HCV infection and immunologic tolerance. The changes of lymphocyte subsets in patients with continuous HCV infection contribute to the progression of chronic hepatitis C.",
        "keywords": [
            "chronic hepatitis C",
            "dentitric cell",
            "flow cytometry",
            "culture in vitro",
            "lymphocyte subsets"
        ],
        "authors": [
            {
                "name": "Jin Bo",
                "org": "PLA Postgraduate Medical School, Beijing , China;302 Hospital of PLA, Beijing ,China"
            },
            {
                "name": "Wang Huifen",
                "org": "302 Hospital of PLA, Beijing ,China"
            },
            {
                "name": "Wang Fusheng",
                "org": "302 Hospital of PLA, Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2008
    },
    "c4w07HrV": {
        "id": "c4w07HrV",
        "title": "Characterization of peripheral dendritic cell subsets and its implication in patients infected with severe acute respiratory syndrome]",
        "abstract": "To investigate the dynamic changes of dendritic cell subsets in peripheral blood of patients infected with severe acute respiratory syndrome (SARS) and evaluate their roles in the immunopathogenesis of SARS.Flow cytometry was applied to study the dynamic alteration of the number and frequencies in circulating DC cell subsets in 30 SARS patients including critical SARS (n = 11) and general SARS (n = 19). The reasons and clinic significances of the peripheral blood DC subsets changes in SARS patients were also analyzed in our study.The patients in critical status had a 9-week course of disease, longer than the 6-week course observed in subjects in general status. The frequency of peripheral DC cell subsets significantly dropped beginning from the onset of symptom in SARS patients and was maintained at significant low levels during the following 4 - 5 weeks, 1.7 +/- 1.8, 5.3 +/- 5.0/ micro l for DC1, 0.57 +/- 1.02, 0.98 +/- 1.11/ micro l for DC2 for cases in critical and general statuses, respectively, compared with healthy subjects; more importantly, the pDC2 even disappeared in the patients who died from SARS diseases. The possible reasons responsible for the alteration of DC subsets in peripheral blood is likely to be the direct attack of SARS-CoVin circulation and be partially involved the application of large dose of steroid. The frequency in DC cell subsets returned to normal level in convalescent stage.Our results showed SARS patients had a significant decrease of circulating DC cell subset frequency, which maybe lead to the host immunodeficiency response to SARS-associated coronavirus (SARS-CoV).",
        "keywords": [],
        "authors": [
            {
                "name": "Zhang Zheng",
                "org": "Research Center for Bio-therapy, PLA 302 Hospital, Beijing 100039, China."
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            },
            {
                "name": "Zhao Min",
                "org": ""
            },
            {
                "name": "Liu Jing-chao",
                "org": ""
            },
            {
                "name": "Xu Dong-ping",
                "org": ""
            },
            {
                "name": "Jin Lei",
                "org": ""
            },
            {
                "name": "Chen Ju-mei",
                "org": ""
            },
            {
                "name": "Wang Min",
                "org": ""
            },
            {
                "name": "Chu Fu-liang",
                "org": ""
            }
        ],
        "venue": "Zhonghua yi xue za zhi",
        "year": 2004
    },
    "UWFYoaQ8": {
        "id": "UWFYoaQ8",
        "title": "Increased infiltration of intrahepatic DC subsets closely correlate with viral control and liver injury in immune active pediatric patients with chronic hepatitis B.",
        "abstract": "The roles of functionally impaired dendritic cells (DCs) in natural history of chronic hepatitis B (CHB) are unknown. We therefore characterized circulating DC subsets in 15 immune tolerant (IT) and 31 immune active (IA) HBV-infected children. Additionally, intrahepatic DC subsets were also analyzed in 4 IT and 9 IA individuals. The results showed that circulating DC subset numbers were decreased, but the intrahepatic DC counts were concomitantly increased in IA patients versus IT patients or healthy children. This results in the reduction of overall IFN-alpha but not IL-12 production by peripheral blood mononuclear cells of IA patients, although the capacity of single DC in producing cytokines was unchanged in these children. Moreover, there is a significantly inverse correlation of intrahepatic DC subsets with plasma HBV load and a positive correlation with serum ALT levels. These findings suggest that the increased infiltration of intrahepatic DC subsets may participate in the local antiviral immune response in pediatric patients with CHB.",
        "keywords": [
            "blood dendritic cell antigen",
            "myeloid dendritic cell",
            "tlr",
            "toll-like receptor",
            "dc",
            "immune tolerance",
            "hpf",
            "it",
            "pdc",
            "dendritic cells",
            "dendritic cell",
            "child",
            "histological activity index",
            "plasmacytoid dendritic cell",
            "ia",
            "pbmc",
            "alt",
            "healthy controls",
            "hai",
            "alanine aminotransferase",
            "interferon-alpha",
            "bdca",
            "immune tolerant",
            "immune active",
            "hbv",
            "chb",
            "hepatitis b virus",
            "hc",
            "chronic hepatitis b",
            "peripheral blood mononuclear cell",
            "high-powered fields",
            "mdc",
            "immune response",
            "natural history"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Dawei Chen",
                "org": ""
            },
            {
                "name": "Jinxia Yao",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Hui Zhang",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Ming Shi",
                "org": "Research Centre for Biological Therapy, Beijing Institute of Infectious Diseases, Beijing 302 Hospital, 100 Xi Si Huan Middle Road, Beijing 100039, China"
            },
            {
                "name": "Hongfei Zhang",
                "org": "The Fifth Clinical Department, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2007
    },
    "rNq8Nfd5": {
        "id": "rNq8Nfd5",
        "title": "Dynamic expression of PD-1 in HBV-specific cytotoxic T lymphocytes correlates with memory T-cell development in acute hepatitis B patients]",
        "abstract": "Programmed death-1 (PD-1) up-regulation impairs virus-specific CD8+ T-cell responses during chronic viral infection. Whether PD-1 expression influences the virus-specific CD8+ T cells in humans with acute viral infection remains largely undefined. This study aims to characterize the PD-1 expression during acute hepatitis B (AHB), and further addresses the association between the PD-1 dynamics and memory T-cell formation during acute HBV infection.Peripheral HBV-specific CD8+ T cells from 11 HLA-A2-positive AHB patients were longitudinally quantitatively analyzed, and PD-1, memory markers CCR7, CD45RA and CD127 and activation marker CD38 on HBV-specific CD8+ T cells were measured using flow cytometric assay. Serum ALT, HBsAg, HBsAb and HBV-DNA levels were evaluated for each subject.All 11 AHB patients examined had multiple pentamer-positive CD8+ T-cell responses in their early phase of HBV infection. Specifically, their PD-1 on pentamer-positive CD8+ T-cells was significantly up-regulated at the onset of their disease. Following their disease resolution, the dynamic decrease in PD-1 expression was found to correlate with the phenotypic development of memory CD8+ T cells, indicated by the increases in CCR7, CD45RA and CD127 and decrease in CD38.PD-1-mediated negative signaling may be closely associated with memory T-cell formation during acute self-limited hepatitis B.",
        "keywords": [],
        "authors": [
            {
                "name": "Gu Lan-lan",
                "org": "Institute of Mincrobiology Chinese Academy of Sciences, Beijing 100101, China."
            },
            {
                "name": "Xu Bin",
                "org": ""
            },
            {
                "name": "Zhang Ji-yuan",
                "org": ""
            },
            {
                "name": "Zhang Zheng",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2008
    },
    "ql002fut": {
        "id": "ql002fut",
        "title": "Differential restoration of myeloid and plasmacytoid dendritic cells in HIV-1-infected children after treatment with highly active antiretroviral therapy.",
        "abstract": "Numerical and functional deficits in myeloid (mDC) and plasmacytoid dendritic cell (pDC) subsets have been found in both adult and pediatric HIV-1 carriers. Whether these impaired DC subsets can be restored after treatment with highly active antiretroviral therapy (HAART) is currently unknown, especially in HIV-1-infected children. In this report, we characterized mDC and pDC subsets in 18 HIV-1-infected children who received HAART treatment and compared them with those in 6 untreated HIV-1-infected children and 27 HIV-1-uninfected healthy children. Among children treated with HAART, 11 were found to suppress HIV-1 replication successfully below the detection limit (HAART-suppressed group) while the remaining 7 failed (HAART-failure group). In HAART-suppressed children, a gradual and complete restoration of the frequency and function of mDCs was observed while the recovery of pDCs was only partial. However, mDC and pDC subsets in HARRT failure children were indistinguishable from the HAART-naive infected children. We also found that mDC frequency and IFN-alpha-releasing capacity of pDC positively correlated with CD4 T cell percentages in all HIV-1-infected children. In HAART-naive children, the mDC frequency correlated the HIV-1-specific CTL frequency. Our findings suggest that HAART has a differential impact on the restoration of mDC and pDC subsets. These findings may help guide the development of HIV-1-specific immune therapy aimed at fully restoring host immune function in chronically HIV-1-infected children.",
        "keywords": [],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Qingxia Zhao",
                "org": "Zhengzhou 6th Hospital(Zhengzhou 6th Hospital),Zhangzhou,China"
            },
            {
                "name": "Yun He",
                "org": "Zhengzhou 6th Hospital(Zhengzhou 6th Hospital),Zhangzhou,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hui Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jinxia Yao",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Linqi Zhang",
                "org": "Chinese Academy of Medical Sciences(Chinese Academy of Medical Sciences),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Journal of immunology (Baltimore, Md. : 1950)",
        "year": 2006
    },
    "13X20OnP": {
        "id": "13X20OnP",
        "title": "Changes of peripheral dendritic cells in chronic hepatitis B patients treated with CINF",
        "abstract": "Objectives:To observe the changes of peripheral dendritic cells subsets consecutively in patients with chronic hepatitis B during Consensus Interferon(CIFN) treatment.Methods:Twenty-three patients with chronic hepatitis B were treated with CIFN for 24 weeks and followed up for another 24 weeks.After CIFN withdrawal,During CIFN treatment peripheral dendritic cell subsets were measured.Results:After CIFN treatment,43.5% patients obtained virological and biochemical responses.The percentage and absolute number of peripheral type I and \u2161dendritic cells decreased greatly(All P<0.05).Conclusions:Consistent virological and biochemical response can be obtained in some patients with chronic hepatitis B virus infection after CIFN treatment,and the percentage and number of peripheral type I and \u2161dendritic cells are greatly decreased too.",
        "keywords": [
            "interferon-alpha",
            "chronic",
            "dendritic cells",
            "hepatitis B",
            "lymphocyte subsets"
        ],
        "authors": [
            {
                "name": "ZHANG Ai-min",
                "org": "PLA 302th Hospital,%%#Beijing %%#,China"
            },
            {
                "name": "WANG Hui-fen",
                "org": "PLA 302th Hospital,%%#Beijing %%#,China"
            },
            {
                "name": "JI Wei",
                "org": "PLA 302th Hospital,%%#Beijing %%#,China"
            },
            {
                "name": "YAN Tao",
                "org": "PLA 302th Hospital,%%#Beijing %%#,China"
            },
            {
                "name": "ZhANG Hui",
                "org": "PLA 302th Hospital,%%#Beijing %%#,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "PLA 302th Hospital,%%#Beijing %%#,China"
            }
        ],
        "venue": "Academic Journal of PLA Postgraduate Medical School",
        "year": 2006
    },
    "IdmZOXGt": {
        "id": "IdmZOXGt",
        "title": "Dysfunction of peripheral blood dendritic cells from patients with chronic hepatitis B virus infection",
        "abstract": "AIM To identify the property of dendritic cells (DCs) of peripheral blood monocytes (PBMC) in patients with chronic HBV infection. METHODS Twenty patients with persistent HBV infection were included in this study, 10 healthy subjects being used as a control group. The peripheral blood mononuclear cells (PBMC) of T cell-depleted populations were incubated and induced into mature dendritic cells in the RPMI-1640 medium in the presence of cytokines GM- CSF, IL-4, FLt-3, TNF-\u03b1 \u03b1 \u03b1 \u03b1 \u03b1 and 100mL\u00b7L -1 of fetal calf serum for a total of 10-12 days. The expressions of surface markers on DCs were evaluated using flow cytometric analysis. ELISA method was used to determine the cytokine levels of interleukin-12 (IL-12) and IL-10 in the supernatant produced by DCs. For detection of the stimulatory capacity of DCs to T cell proliferation, mytomycin C-treated DC were incubated with allogenic T cells. RESULTS A typical morphology of mature DCs from healthy subjects and HBV-infected patients was induced in in vitro incubation, but the proliferation ability and cellular number of DCs from HBV-infected patients significantly decreased compared with healthy individuals. In particular, the expression levels of HLA- DR, CD80 (B7-1) and CD86 (B7-2) on DC surface from patients were also lower than that from healthy individuals (0.46 vs 0.92 for HLA-DR, 0.44 vs 0.88 for CD80 and 0.44 vs 0.84 for CD86, P<0.05). The stimulatory capacity and production of IL-12 of DCs from patients in allogenic mixed lymphocyte reaction (AMLR) significantly decreased, but the production level of nitric oxide (NO) by DCs simultaneously increased compared with healthy subjects (86\u00b115 vs 170\u00b122 \u00b5 \u00b5 \u00b5 \u00b5 \u00b5mol\u00b7L-1, P<0.05).",
        "keywords": [
            "peripheral blood mononuclear cell",
            "cell proliferation",
            "control group"
        ],
        "authors": [
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Li-He Xing",
                "org": ""
            },
            {
                "name": "Ming-Xu Liu",
                "org": ""
            },
            {
                "name": "Chuan-Lin Zhu",
                "org": ""
            },
            {
                "name": "Hui-Gang Liu",
                "org": ""
            },
            {
                "name": "Hui-Fen Wang",
                "org": ""
            },
            {
                "name": "Zhou-Yun Lei",
                "org": ""
            },
            {
                "name": "Wang FS",
                "org": ""
            },
            {
                "name": "Xing LH",
                "org": ""
            },
            {
                "name": "Liu MX",
                "org": ""
            },
            {
                "name": "Zhu CL",
                "org": ""
            },
            {
                "name": "Liu HG",
                "org": ""
            },
            {
                "name": "Wang HF",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "OKacK7tH": {
        "id": "OKacK7tH",
        "title": "Treatment of renal struvite staghorn calculi complicated with pyonephrosis via percutaneous nephrolithotomy",
        "abstract": "Objective To evaluate the efficacy and safety of percutaneous nephrolithotomy for renal struvite staghon calculi complicated with pyonephrosis. Methods 45 patients who caught struvite staghon calculi complicated with pyonephrosis were analysised. Pyonephrosis was found in 27 patients pre-operation.18 patients were found complicated with pyonephrosis during operation.Urine culture were performed in all the patients before operation and percutanous nephrorithotomy were perfoumed after antibiotics treating. The tract was dilated to F24 and the stones were removed by EMS lithotrity system.The operation time were limited in two hours whenever the stone free or not. Results 32 patients were free-stone after first stage percutaneous nephrorithotomy and 8 patients were underwent second stage operation fore residual stones. 5 patients were cured by EWSL after first stsge operation. All the patients caught fever after operation and 17 patients' temperature were above 38.5\u2103. The blood culture were performed in all the patients.and bactermia and septicemia were not found. Conclusion Percutaneous nephrorithotomy of standard tract is a safe and effective procedure for struvite stahgorn caculi complicated with pyonephrosis.",
        "keywords": [
            "Struvite stahgorn caculi",
            "Pyonephrosis",
            "Percutaneous nephrolithotomy"
        ],
        "authors": [
            {
                "name": "ZHOU Da-qing",
                "org": ". Department of Urology, 303th Hospital of People\u2032s Liberation Army, Nanning , China"
            },
            {
                "name": "WANG Jian",
                "org": ". Department of Urology, 303th Hospital of People\u2032s Liberation Army, Nanning , China"
            },
            {
                "name": "LI Wen-gang",
                "org": ". Department of Urology, 303th Hospital of People\u2032s Liberation Army, Nanning , China"
            },
            {
                "name": "PANG Xiang",
                "org": ". Department of Urology, 303th Hospital of People\u2032s Liberation Army, Nanning , China"
            },
            {
                "name": "YU Xiao-xiang",
                "org": ". Department of Urology, 303th Hospital of People\u2032s Liberation Army, Nanning , China"
            },
            {
                "name": "JIANG Bo",
                "org": ". Department of Urology, 303th Hospital of People\u2032s Liberation Army, Nanning , China"
            }
        ],
        "venue": "The Journal of Practical Medicine",
        "year": 2011
    },
    "B6aZ3lRe": {
        "id": "B6aZ3lRe",
        "title": "B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection.",
        "abstract": "Impaired myeloid dendritic cells (mDC) fail to elicit host antiviral immune responses, leading to disease progression in HIV-1 infection. However, mechanisms underlying mDC suppression remain elusive. In this study, we found that the T-cell co-stimulatory molecule programmed death-1 ligand-1 (B7-H1) is significantly up-regulated on peripheral mDC in HIV-1-infected typical progressors and AIDS patients, but is maintained at a relatively low level in long-term non-progressors. Successful immune reconstitution after highly active antiretroviral therapy, indicated by full suppression of HIV-1 replication and substantial increases of CD4 T-cell counts, correlated with a decrease in B7-H1 expression. Importantly, we also found that X4 HIV-1 isolates directly induced B7-H1 expression on mDC in vitro, while adding antiviral agents hampered this B7-H1 up-regulation. Blockade of B7-H1 in vitro strongly enhanced mDC-mediated allostimulatory capacity and IL-12 production. In contrast, B7-H1 ligation with soluble programmed death-1 (PD-1) reduced mDC maturation and IL-12 production but increased mDC apoptosis and IL-10 production. Thus, B7-H1 up-regulation may inhibit mDC-mediated immune response, thereby facilitating viral persistence and disease progression in HIV-1-infected patients. This study provides new evidence that B7-H1 inhibitory signaling may reversely mediate functional impairment of mDC in HIV-1 infection, which further supports the notion that B7-H1 blockade represents a novel therapeutic approach to this disease.",
        "keywords": [
            "myeloid dendritic cells",
            "co-stimulation",
            "b7-h1",
            "pd-1",
            "hiv",
            "pd 1"
        ],
        "authors": [
            {
                "name": "Xicheng Wang",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Shuye Zhang",
                "org": ""
            },
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Jinxia Yao",
                "org": ""
            },
            {
                "name": "Yanmei Jiao",
                "org": ""
            },
            {
                "name": "Hao Wu",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "European journal of immunology",
        "year": 2008
    },
    "yU59QHSR": {
        "id": "yU59QHSR",
        "title": "Clinical profiles of circulating dendritic cell phenotype and lymphocyte subsets in patients chronically infected with HBV during lamivudine treatment]",
        "abstract": "To investigate the changes of circulating dendritic cell (DC) and lymphocytes subsets in chronic hepatitis B patients treated with lamivudine.Sixteen chronic hepatitis B patients treated with lamivudine were included and followed up for 48 weeks in this study. Before and during lamivudine treatment, DC collected from peripheral blood sample was cultured in vitro and surface markers of DC and lymphocytes subsets were detected by flow cytometry simultaneously.Of the 16 patients, 11 were consistently HBV DNA negative in serum and HBV DNA YMDD variants appeared in 5 cases. In the consistent responder group, HLA-DR level of DC decreased transiently in 12 weeks and recovered in 48 weeks (P<0.05). At 48 weeks CD80, CD40 and CD1a were improved compared with baseline level (P<0.05). In the YMDD variant group, CD83 and HLA-DR level of DC decreased at 12 weeks treatment (P<0.05) and HLA-DR was still lower compared with baseline (P<0.05). In the consistent responder group, no significant changes occurred in lymphocyte subsets number at 12 weeks treatment, but CD4 + T cell was improved and NK cell dropped at 48 weeks compared with baseline level (P<0.05). In the YMDD variant group lymphocyte subsets had no statistically significant change.In the consistent responder group, the expression of surface costimulatory molecules of DC, such as CD80 and CD40,was partly recovered after the virus of hepatitis B had been inhibited efficiently, HLA-DR levels of DC decreased transiently at 12 weeks and recovered in 48 weeks and CD4+ T cell improved and NK cell dropped at 48 weeks. In the YMDD variant group, HLA-DR levels of DC were lower consistently during treatment compared with baseline level.",
        "keywords": [
            "lamivudine",
            "hepatitis b",
            "dendritic cells",
            "chronic",
            "lymphocyte subsets"
        ],
        "authors": [
            {
                "name": "LI Han-wei",
                "org": ". No.302 Hospital of the People's Liberation Army,Beijing,,China"
            },
            {
                "name": "WANG Hui-fen",
                "org": ". No.302 Hospital of the People's Liberation Army,Beijing,,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". No.302 Hospital of the People's Liberation Army,Beijing,,China"
            },
            {
                "name": "JIN Bo",
                "org": ". No.302 Hospital of the People's Liberation Army,Beijing,,China"
            },
            {
                "name": "DUAN Xue-zhang",
                "org": ". No.302 Hospital of the People's Liberation Army,Beijing,,China"
            }
        ],
        "venue": "Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology",
        "year": 2006
    },
    "p9dpV547": {
        "id": "p9dpV547",
        "title": "Clinical observation of combined cavity interventional therapy and traditional Chinese medicine on prostatitis type \u2162",
        "abstract": "\u3010Objective\u3011 To investigate the effect of combined cavity interventional therapy and traditional chinese medicine on prostatitis type \u2162.\u3010Methods\u3011 The patients were divided into 3 groups,cavity interventional therapy combined with traditional Chinese medicine group(n =119) was treated cavity interventional combined with Traditional Chinese Medicine,cavity interventional therapy group(n =119) and traditional Chinese medicine group(n =119) were given with(n =119) cavity interventional or traditional Chinese medicine only.The treatment lasted 3 weeks.Chronc prostatitis symptoms index issued by American national institute of heath(NIH-CPSI),white blood cells(WBC) count and the amount of lecithin body in prostatic secretion,and urinary flow rate were examined before and after the treatment.\u3010Results\u3011 In cavity interventional therapy combined with traditional Chinese medicine group,the clinical symptoms were relieved,WBC count and the amount of lecithin body in prostatic secretion were reduced,and urinary flow rate was increased.\u3010Conclusions\u3011 The therapy of combined cavity interventional therapy and traditional Chinese medicine has a good effect in improving the symptoms and signs,the therapeutic mechanism is worth further studying.",
        "keywords": [
            "traditional Chinese medicine",
            "prostatitis type \u2162",
            "cavity interventional therapy"
        ],
        "authors": [
            {
                "name": "PAN Xiao-qing",
                "org": "Department of Urology surgery,303 Hospital of people's Liberation Army, Nanning,Guangxi ,P.RChina"
            },
            {
                "name": "HE Yan-fang",
                "org": "Department of Urology surgery,303 Hospital of people's Liberation Army, Nanning,Guangxi ,P.RChina"
            },
            {
                "name": "WANG Jian",
                "org": "Department of Urology surgery,303 Hospital of people's Liberation Army, Nanning,Guangxi ,P.RChina"
            },
            {
                "name": "ZHOU Da-qing",
                "org": "Department of Urology surgery,303 Hospital of people's Liberation Army, Nanning,Guangxi ,P.RChina"
            },
            {
                "name": "LI Wen-gang",
                "org": "Department of Urology surgery,303 Hospital of people's Liberation Army, Nanning,Guangxi ,P.RChina"
            }
        ],
        "venue": "China Journal of Modern Medicine",
        "year": 2011
    },
    "G0loQsm5": {
        "id": "G0loQsm5",
        "title": "B7-H1 up-regulation on myeloid dendritic cells significantly suppresses T cell immune function in patients with chronic hepatitis B.",
        "abstract": "Although dysfunctional dendritic cells contribute to inadequate adaptive immunity in chronic hepatitis B (CHB), underlying molecular mechanisms remain largely undefined. In this study, we examined B7-H1 expression on circulating myeloid dendritic cells (mDCs) in 46 CHB patients, 10 autoimmune hepatitis patients, and 10 healthy subjects as control. We found that B7-H1 expression is significantly up-regulated on circulating mDCs of CHB and autoimmune hepatitis patients compared with healthy individuals. The B7-H1 up-regulation was significantly correlated with an elevation of serum alanine aminotransaminase levels and plasma viral load. In addition, in vitro, both IFN-alpha and IFN-gamma could strongly stimulate mDCs to express B7-H1. More importantly, elevated B7-H1 expression is also closely associated with the suppression of T cell immune function. In vitro blockade of B7-H1 signaling could not only down-regulate IL-10 and up-regulate IL-12 production by mDCs, but also enhance mDC-mediated allostimulatory capacity and cytokine production of T cells. Blockade of B7-H1 signaling could improve hepatitis B c Ag-pulsed monocyte-derived DC-induced IFN-gamma production by autologous hepatitis B virus-specific T cells. These new findings suggested that chronic inflammation may contribute to B7-H1 up-regulation on mDCs in CHB patients, which potentially cause defective hepatitis B virus-specific T cell function and viral persistence. Our findings further support the notion that the blockade of B7-H1 may represent a novel therapeutic approach for this disease.",
        "keywords": [
            "immune function",
            "molecular mechanics",
            "viral load"
        ],
        "authors": [
            {
                "name": "Liangen Chen",
                "org": ""
            },
            {
                "name": "Weiwei Chen",
                "org": ""
            },
            {
                "name": "Zhi-dong Zhang",
                "org": ""
            },
            {
                "name": "Yong-Gang Li",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Jiyuan Zhang",
                "org": ""
            },
            {
                "name": "Lieping Chen",
                "org": ""
            },
            {
                "name": "Shengdian Wang",
                "org": ""
            },
            {
                "name": "Fu-sheng Wang",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            }
        ],
        "venue": "Journal of immunology (Baltimore, Md. : 1950)",
        "year": 2007
    },
    "qJHF5cai": {
        "id": "qJHF5cai",
        "title": "PD-1 and PD-L1 upregulation promotes CD8<sup>+</sup>T-cell apoptosis and post-operative recurrence in hepatocellular carcinoma patients",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Feng Shi",
                "org": ""
            },
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Zhen Zeng",
                "org": ""
            },
            {
                "name": "Rui-Zhao Qi",
                "org": ""
            },
            {
                "name": "Zhen-Wen Liu",
                "org": ""
            },
            {
                "name": "Ji-Yuan Zhang",
                "org": ""
            },
            {
                "name": "Yong-Ping Yang",
                "org": ""
            },
            {
                "name": "Po Tien",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "International Journal of Cancer",
        "year": 2010
    },
    "W08rEYbk": {
        "id": "W08rEYbk",
        "title": "Synergetic anticancer effect of combined quercetin and recombinant adenoviral vector expressing human wild-type p53, GM-CSF and B7-1 genes on hepatocellular carcinoma cells in vitro.",
        "abstract": "This study investigated the anti-cancer effect of combined quercetin and a recombinant adenovirus vector expressing the human p53, GM-CSF and B7-1 genes (designated BB-102) on human hepatocellular carcinoma (HCC) cell lines in vitro.The sensitivity of HCC cells to anticancer agents was evaluated by 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. The viability of cells infected with BB-102 was determined by trypan blue exclusion. The expression levels of human wild-type p53, GM-CSF and B7-1 genes were determined by Western blot, enzyme-linked immunosorbent assay (ELISA) and flow cytometric analysis, respectively. The apoptosis of BB-102-infected or quercetin-treated HCC cells was detected by terminal deoxynucleotidyl transferase (TdT) assay or DNA ladder electrophoresis.Quercetin was found to suppress proliferation of human HCC cell lines BEL-7402, HuH-7 and HLE, with peak suppression at 50 micromol/L quercetin. BB-102 infection was also found to significantly suppress proliferation of HCC cell lines. The apoptosis of BB-102-infected HCC cells was greater in HLE and HuH-7 cells than in BEL-7402 cells. Quercetin did not affect the expression of the three exogenous genes in BB-102-infected HCC cells (P>0.05), but it was found to further decrease proliferation and promote apoptosis of BB-102-infected HCC cells.BB-102 and quercetin synergetically suppress HCC cell proliferation and induce HCC cell apoptosis, suggesting a possible use as a combined anti-cancer agent.",
        "keywords": [
            "wild type",
            "terminal deoxynucleotidyl transferase",
            "adenoviral vector",
            "cell line",
            "cell proliferation"
        ],
        "authors": [
            {
                "name": "Ming Shi",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            },
            {
                "name": "Zu-Ze Wu",
                "org": ""
            },
            {
                "name": "Fengtai Lu",
                "org": ""
            }
        ],
        "venue": "World journal of gastroenterology : WJG",
        "year": 2003
    },
    "9ucQdABy": {
        "id": "9ucQdABy",
        "title": "Characteristics of peripheral circulating lymphocyte subsets and their clinical implication in severe hepatitis patients with chronic HBV infection",
        "abstract": "Objective:To investigate the characteristics of peripheral circulating lymphocyte subsets in severe hepatitis patients with chronic HBV infection(SHPCHI).Methods: The numbers of circulating lymphocyte subsets,including CD3~(+),CD4~(+) and CD8~(+),NK cells(CD3~(-)/CD16~(+)/CD56~(+)),and NKT cells(CD3~(+)/CD16~(+)CD56~(+)),were determined in SHPCHI((n=61),)patients with chronic hepatitis B(CHB,n=21),patients with cirrhosis(LC,n=26) and healthy volunteers(n=10) by flow cytometry.The absolute values of each lymphocyte subset were calculated and statistically analyzed.Results: The absolute numbers of circulating CD3~(+),CD4~(+)and CD8~(+) T cells were significantly reduced in SHPCHI group compared with those in the other 3 groups(P<0.01 or P<(0.05).) There was a decreasing trend in the absolute numbers of peripheral CD3~(+),CD4~(+),CD8~(+) and NK cells in non-surviving SHPCHI compared with surviving SHPCHI,but the decrease was not statistically significant.Conclusion: SHPCHI has an disorderd cellular immune function,which might be related to the prognosis of SHPCHI.",
        "keywords": [
            "lymphocytes",
            "chronic",
            "hepatitis B",
            "prognosis"
        ],
        "authors": [
            {
                "name": "XIN Shao-jie",
                "org": "The 3rd Infectious Department,No.302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZOU Zheng-sheng",
                "org": "The 4th Infectious Department,No.302 Hospital of PLA"
            },
            {
                "name": "LI Bao-sen",
                "org": "The 4th Infectious Department,No.302 Hospital of PLA"
            },
            {
                "name": "ZHAO Jun",
                "org": "The 4th Infectious Department,No.302 Hospital of PLA"
            },
            {
                "name": "XU Dong-ping",
                "org": "Research Center of Biological Therapy,Beijing Institute of Infectious Diseases of PLA"
            },
            {
                "name": "CHEN Li-ming",
                "org": "The 6th Infectious Department,No.302 Hospital of PLA"
            },
            {
                "name": "XING Han-qian",
                "org": "The 3rd Infectious Department,No.302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "JIN Lei",
                "org": "Research Center of Biological Therapy,Beijing Institute of Infectious Diseases of PLA"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Research Center of Biological Therapy,Beijing Institute of Infectious Diseases of PLA"
            }
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2006
    },
    "WTs7Hx5R": {
        "id": "WTs7Hx5R",
        "title": "Frequency and absolute number of FoxP3<sup>+</sup> regulatory T cells correlate with disease progression of chronic HIV-1 infection",
        "abstract": "CD4+CD25+ Regulatory T cells (Treg) have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion\n of Treg benefits to the disease status of HIV infection remains undefined. To address this issue, we enumerated the Treg absolute\n counts and frequency in 75 antiviral-na\u00efve HIV-1-infected individuals in this study. It was found that HIV-infected patients\n displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition, with disease\n progression indicated by CD4 T-cell absolute counts, circulating Treg frequency gradually increased; while Treg absolute counts\n were gradually decreased, suggesting that the alteration of Treg number closely correlated with disease progression in HIV\n infection. Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro.\n Thus, our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection, influencing the disease\n progression.",
        "keywords": [
            "proliferation",
            "t-lymphocytes",
            "tolerance/suppression/anergy",
            "hiv infections"
        ],
        "authors": [
            {
                "name": "Jun-liang Fu",
                "org": "Beijing 302 Hospital Research Center of Biological Therapy, Beijing Institute of Infectious Diseases 100 Xi Si Huan Middle Road Beijing 100039 China"
            },
            {
                "name": "Fu-biao Kang",
                "org": "Military Postgraduate Medical College Postgraduate Team Beijing 100853 China"
            },
            {
                "name": "Yan-mei Jiao",
                "org": "Beijing You-An Hospital Affiliated to Capital University of Medical Science Department of Infectious Diseases Beijing 100054 China"
            },
            {
                "name": "Shao-jun Xing",
                "org": "Beijing 302 Hospital Research Center of Biological Therapy, Beijing Institute of Infectious Diseases 100 Xi Si Huan Middle Road Beijing 100039 China"
            },
            {
                "name": "Bao-yun Fu",
                "org": "Beijing 302 Hospital Research Center of Biological Therapy, Beijing Institute of Infectious Diseases 100 Xi Si Huan Middle Road Beijing 100039 China"
            },
            {
                "name": "Chun-bao Zhou",
                "org": "Beijing 302 Hospital Research Center of Biological Therapy, Beijing Institute of Infectious Diseases 100 Xi Si Huan Middle Road Beijing 100039 China"
            },
            {
                "name": "Xi-cheng Wang",
                "org": "Beijing You-An Hospital Affiliated to Capital University of Medical Science Department of Infectious Diseases Beijing 100054 China"
            },
            {
                "name": "Hao Wu",
                "org": "Beijing You-An Hospital Affiliated to Capital University of Medical Science Department of Infectious Diseases Beijing 100054 China"
            },
            {
                "name": "Fu-Sheng WANG",
                "org": "Beijing 302 Hospital Research Center of Biological Therapy, Beijing Institute of Infectious Diseases 100 Xi Si Huan Middle Road Beijing 100039 China"
            }
        ],
        "venue": "Virologica Sinica",
        "year": 2007
    },
    "pxOBQ3Lb": {
        "id": "pxOBQ3Lb",
        "title": "Response to interferon-\u03b1 treatment correlates with recovery of blood plasmacytoid dendritic cells in children with chronic hepatitis B",
        "abstract": "Results All patients exhibited an initially rapid decrease of circulating pDC numbers and CpG-induced endogenous interferon-\u03b1 production within 2 weeks of interferon-\u03b1 treatment. Subsequently, all responders displayed a continuous increase of both pDC numbers and function peaking around week 12. These responses were consequently accompanied by viral clearance, hepatitis B e antigen seroconversion, and the improvement of circulating myeloid dendritic cells and type 1 T helper cytokine levels. However, non-responders lacked these sequential responses compared with responders. Conclusions pDCs may actively correlate with interferon-\u03b1 therapy-induced viral clearance in pediatric patients with CHB. The recovery of blood pDC number and function may represent a prognostic marker for favourable response to interferon-\u03b1 treatment in chronic hepatitis B.",
        "keywords": [
            "dendritic cells",
            "plasmacytoid dendritic cells",
            "hepatitis b virus",
            "antiviral therapy",
            "response",
            "interferon-\u03b1",
            "children"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Hongfei Zhang",
                "org": "The Fifth Clinical Department, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Dawei Chen",
                "org": "The Fifth Clinical Department, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Jinxia Yao",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Junliang Fu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Journal of Hepatology",
        "year": 2007
    },
    "T3DjKedX": {
        "id": "T3DjKedX",
        "title": "Establishment of on-site disposal mode of sudden and mass infectious disease outbreaks in the army",
        "abstract": "Due to the special nature of the army,sudden and mass infectious disease outbreaks have sometimes occurred.The authors analyze the risk factors,types and characteristics of infectious disease outbreaks,and explore the on-site epidemic disposal mode,that is,through strong organization and leadership and under the guidance of the experts,on-site epidemiological investigations of sudden and mass infectious disease outbreaks in the army are carried out,and medical care and disposal of medical waste and pollutants are implemented.Through supervision and inspection of the implementation of various prevention and control measures,logistics support,psychological counselling and health education should be strengthened to ensure timely and effective epidemic control,improve treatment rates and reduce the mortality.",
        "keywords": [
            "communicable diseases",
            "military medicine",
            "disease notification"
        ],
        "authors": [
            {
                "name": "QIN En-qiang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Xin",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "NIE Wei-min",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHOU Zhi-ping",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LI Wen-gang",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHAO Peng",
                "org": " Treatment and Research Center for Infectious Diseases,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Infectious Disease Information",
        "year": 2011
    },
    "kLsQzCMl": {
        "id": "kLsQzCMl",
        "title": "Human umbilical cord mesenchymal stem cells improve liver function and ascites in decompensated liver cirrhosis patients.",
        "abstract": "Decompensated liver cirrhosis (LC), a life-threatening complication of chronic liver disease, is one of the major indications for liver transplantation. Recently, mesenchymal stem cell (MSC) transfusion has been shown to lead to the regression of liver fibrosis in mice and humans. This study examined the safety and efficacy of umbilical cord-derived MSC (UC-MSC) in patients with decompensated LC. A total of 45 chronic hepatitis B patients with decompensated LC, including 30 patients receiving UC-MSC transfusion, and 15 patients receiving saline as the control, were recruited; clinical parameters were detected during a 1-year follow-up period. No significant side-effects and complications were observed in either group. There was a significant reduction in the volume of ascites in patients treated with UC-MSC transfusion compared with controls (P < 0.05). UC-MSC therapy also significantly improved liver function, as indicated by the increase of serum albumin levels, decrease in total serum bilirubin levels, and decrease in the sodium model for end-stage liver disease scores. UC-MSC transfusion is clinically safe and could improve liver function and reduce ascites in patients with decompensated LC. UC-MSC transfusion, therefore, might present a novel therapeutic approach for patients with decompensated LC.",
        "keywords": [
            "human",
            "umbilical cord",
            "stem cell",
            "liver cirrhosis",
            "ascites"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hu Lin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ming Shi",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Ruonan Xu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Junliang Fu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Jiyun Lv",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Liming Chen",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Sa Lv",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Yuanyuan Li",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Shuangjie Yu",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Hua Geng",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Lei Jin",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "George K K Lau",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            },
            {
                "name": "Fusheng Wang",
                "org": "302 Hospital of People's Liberation Army(302 Hospital of PLA),Beijing,China"
            }
        ],
        "venue": "Journal of gastroenterology and hepatology",
        "year": 2012
    },
    "egWrMweL": {
        "id": "egWrMweL",
        "title": "Retrovirus-mediated expression of dual-target antisense RNA in liver cells of transgenic mice and its influence on replication of hepatitis B virus",
        "abstract": "AIM: To detect the expression of X and P region dual-target antisense RNA of hepatitis B virus (HBV) mediated by ratroviral vector in the liver cells of transgenic mice and its effect on the replication of HBV DNA. METHODS: The recombinant retroviral vector plasmids expressing dual-target antisense RNA complementary to HBV X and P region were constructed and then injected into the transgenic mice. The experimental mice were divided into blank, pLXSN, pLXSN-asX, pLXSN-asP, pLXSN-asXP, and pLXSN-seXP group. The total RNA, extracted from the mice at the 8th wk, was reversely transcribed, and then the cDNA was amplified with polymerase chain reaction (PCR). Thereafter, agarose gel electrophoresis, sequencing analysis and fluorescent PCR were performed. The replication of HBV DNA was tested by fluorescence quantitative PCR. RESULTS: The HBV dual-target antisense RNA was expressed in the liver cells of mice and with high efficiency. After 8 wk, the replications of HBV DNA (\u00d7105 copies/g) were 7.24\u00b11.62, 9.49\u00b13.34, 2.60\u00b11.13, 2.83\u00b11.67, 3.24\u00b10.45, 6.52\u00b11.53 in blank, pLXSN, pLXSN-asX, pLXSN-asP, pLXSN-asXP and pLXSN-seXP group. The levels of HBV DNA were significantly higher in single-or dual-target antisense RNA groups than those in other groups (P < 0.05). However, there were no marked differences between control groups as well as between single-target and dual-target group (P > 0.05). CONCLUSION: The hepatitis B virus dual-target antisense RNA can be expressed in the liver cells of transgenic mice with high efficiency, and it can inhibit the replication of HBV DNA in mice liver. However, there is no significant difference between single-target and dual-target RNA.",
        "keywords": [
            "HBV DNA",
            "Hepatitis B virus",
            "Dual-target antisense RNA",
            "Transgenic mice"
        ],
        "authors": [
            {
                "name": "Zheng Zhang",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            },
            {
                "name": "Hong-Li Xi",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            },
            {
                "name": "Wei-Bo Gong",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            },
            {
                "name": "Wen-Gang LI",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            },
            {
                "name": "Min Yu",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            },
            {
                "name": "Zheng Zeng",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            },
            {
                "name": "Xiao-Yuan Xu",
                "org": ", Department of Infectious Diseases, the First Hospital of Peking University, Beijing , China"
            }
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2006
    },
    "s1ZBe2bk": {
        "id": "s1ZBe2bk",
        "title": "Decreased frequency and function of circulating plasmocytoid dendritic cells (pDC) in hepatitis B virus infected humans.",
        "abstract": "The Type 2 precursor plasmacytoid dendritic cells (pDC) represent the most important cell type in antiviral innate immunity. To understand the function of pDC during hepatitis B virus infection, the frequency and function of circulating pDC were analyzed by flow cytometric analysis, and IFN-alpha secretion of total PBMCs was determined by ELISA assay in 25 healthy subjects and 116 patients at various stages of chronic hepatitis B virus infection (CHB). The number of circulating pDC was found to be significantly lower in patients with CHB and associated liver cirrhosis (LC). The ability of PBMCs to secrete IFN-alpha also decreased significantly. There was a corresponding decrease of circulating NK cells and CD8+ T cells. We observed that lamuvidine antiviral therapy restored the number of circulating pDC and there was a reversal of pDC frequency with the control of HBV replication in chronic HBV patients, indicating these subjects are unlikely to be totally immunocompromised. The decrease of pDC was found to be related to nosocomial infections in LC patients. Our results suggest that CHB patients probably have a quantitative and qualitative impairment of circulating pDC or NK cells, which may be associated with HBV persistent infection as well as the nosocomial infections that arise in LC patients.",
        "keywords": [
            "nosocomial infections.",
            "liver cirrhosis",
            "dendritic cells",
            "chronic hepatitis",
            "innate immunity",
            "cd8 t cell"
        ],
        "authors": [
            {
                "name": "XUE-ZHANG DUAN",
                "org": ""
            },
            {
                "name": "MIN WANG",
                "org": ""
            },
            {
                "name": "HAN-WEI LI",
                "org": ""
            },
            {
                "name": "HUI ZHUANG",
                "org": ""
            },
            {
                "name": "DONGPING XU",
                "org": ""
            },
            {
                "name": "FU-SHENG WANG",
                "org": "Research Centre of Biological Therapy|Institute of Infectious Diseases"
            }
        ],
        "venue": "Journal of clinical immunology",
        "year": 2004
    },
    "lmksKebI": {
        "id": "lmksKebI",
        "title": "Treatment of chronic hepatitis C complicated with thyroid disease by peginterferon alfa-2a: 3 cases report]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Yu Shuang-jie",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China."
            },
            {
                "name": "Geng Hua",
                "org": ""
            },
            {
                "name": "Chen Li-ming",
                "org": ""
            },
            {
                "name": "Lv Sa",
                "org": ""
            },
            {
                "name": "Wang Fu-sheng",
                "org": ""
            }
        ],
        "venue": "Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology",
        "year": 2011
    },
    "FIXwmQph": {
        "id": "FIXwmQph",
        "title": "The phenotype and function of CD_4~+ CD_(25)~+ regulatory T cells in hepatitis B patients",
        "abstract": "Objective Our aim was to investigate the frequency,phenotype and function of CD_4~+CD_(25)~(high)regulatory T cells(Treg)in patients with acute and chronic hepatitis B(AHB,CHB). Methods Peripheral blood mononuclear cells(PBMCs)from 16 AHB patients at acute phase(week 1 of illness),72 CHB patients,and 32 health subjects were analyzed for Treg frequency and CD_(45)RO,CD_(45)RA, CD_(95)and HLA-DR phenotype by flow cytometry.Intracellular expression of cytotoxic T lymphocyte- associated antigen-4(CTLA-4)was examined by intracellular cytokines staining.Forkhead/winged helix transcription factor(FoxP3)mRNA was detected by a real-time RT-PCR assay.The effects of MACS magnetic beads-purified Treg cells on the proliferation of PBMCs were examined by a [~3H]-thymidine incorporation assay.The effect of Treg cells on IFN\u03b3secretion of autologous PBMCs was examined by ELISA.Results CHB patients presented a higher fraction of circulating CD_4~+ CD_(25)~(high)Treg frequency than AHB patients(P\uff1c0.05),but had no significant difference compared with healthy controls.CD_4~+ CD_(25)~(high) Treg expressed high levels of CD_(45)RO,HLA-DR and CTLA-4,low level of CD_(45)RA,and expressed FoxP3 mRNA specifically.We also observed that Treg cells could suppress the expansion and IFN\u03b3secretion of autologous PBMCs when stimulated with HBV antigen or anti-CD_3 antibody,and the suppressive effect was stronger when HBV antigen was used as stimulator.Conclusions CHB patients presented a higher fraction of circulating Treg frequency than AHB patients at acute phase,but had no significant difference compared with healthy controls.FoxP3 mRNA was specifically expressed in CD_4~+ CD_(25)~+ cell population.Treg could suppress HBV antigen-specific T cell response in vitro.The study furthers our understanding of Treg's role in immunopathogenesis of hepatitis B.",
        "keywords": [
            "T-lymphocytes",
            "Hepatitis B",
            "Immune tolerance"
        ],
        "authors": [
            {
                "name": "FU Jun-liang",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            },
            {
                "name": "XU Dong-ping",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            },
            {
                "name": "SHI Ming",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            },
            {
                "name": "ZHANG Hui",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            },
            {
                "name": "JIN Lei",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            },
            {
                "name": "TANG Zi-rong",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ". Research Center of Biological Therapy,the 302th Hospital of PIM,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Internal Medicine",
        "year": 2006
    },
    "oX0Hmc3l": {
        "id": "oX0Hmc3l",
        "title": "Imbalanced Intrahepatic Cytokine Expression of Interferon-\u03b3, Tumor Necrosis Factor-\u03b1, and Interleukin-10 in Patients With Acute-on-Chronic Liver Failure Associated With Hepatitis B Virus Infection: ",
        "abstract": "",
        "keywords": [
            "Acute-on-chronic liver failure",
            "Immunohistochemistry",
            "Interferon-\u03b3",
            "Interleukin-10",
            "Tumor necrosis factor-\u03b1"
        ],
        "authors": [
            {
                "name": "Zhengsheng Zou",
                "org": ""
            },
            {
                "name": "Baosen Li",
                "org": ""
            },
            {
                "name": "Dongping Xu",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Jing-Min Zhao",
                "org": ""
            },
            {
                "name": "Guangde Zhou",
                "org": ""
            },
            {
                "name": "Yanling Sun",
                "org": ""
            },
            {
                "name": "Lei Huang",
                "org": ""
            },
            {
                "name": "Junliang Fu",
                "org": ""
            },
            {
                "name": "Yongping Yang",
                "org": ""
            },
            {
                "name": "Lei Jin",
                "org": ""
            },
            {
                "name": "Wei Zhang",
                "org": ""
            },
            {
                "name": "Jun Zhao",
                "org": ""
            },
            {
                "name": "Ying Sun",
                "org": ""
            },
            {
                "name": "Shaojie Xin",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Journal of Clinical Gastroenterology",
        "year": 2009
    },
    "hNOvylbI": {
        "id": "hNOvylbI",
        "title": "Current perspectives on immune pathogenesis and immune therapy of chronic hepatitis B",
        "abstract": "",
        "keywords": [
            "immunity",
            "chronic",
            "hepatitis B",
            "hepatitis B virus"
        ],
        "authors": [
            {
                "name": "ZHANG Zheng",
                "org": "Research Center for Biological Therapy,Beijing 302 Hospital,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": "Research Center for Biological Therapy,Beijing 302 Hospital,Beijing ,China"
            }
        ],
        "venue": "Journal of Clinical Hepatology",
        "year": 2012
    },
    "eDb56JAt": {
        "id": "eDb56JAt",
        "title": "Changes in PD-1 and effect thereof on prognosis of patient after argon-helium cryoablation for hepatitis B related-hepatocellular carcinoma",
        "abstract": "Objective To investigate the relationship of the expression of circulating programmed death-1(PD-1) to the disease course of hepatocellular carcinoma(HCC),to explore the influence of cryoablation on the changes in PD-1 in peripheral blood,and to analyze the correlation between PD-1 and the prognosis of HCC patients.Methods The expression of circulating PD-1 was determined by flow cytometry to analyze the correlation between the expressions of PD-1 and progression of HCC.Of 141 patients with HCC,109 underwent argon-helium cryoablation,the expressions of PD-1 in peripheral blood pre-and post-therapy were then detected and the changes were recorded thereafter.According to median percentage of PD-1 pre-cryoablation,46 patients with early-stage HCC were assigned into low-expression group(PD-1 4.05%\u00b11.28%,n=23) and high-expression group(9.26%\u00b1 3.09%,n=23),and 63 patients with intermediate-stage HCC into low-expression group(9.26%\u00b11.63%,n=31) and high-expression group(18.05%\u00b13.78%,n=32).The tumor free survival(TFS) and overall survival(OS) were calculated and compared by using Kaplan-Meier Survival Analysis.Results The expression of circulating PD-1 were 6.66%\u00b13.52% in BCLC early-stage patients with HCC,13.72%\u00b15.29% in intermediate-stage cases,and 20.28%\u00b111.89%% in advanced-stage cases.After cryoablation,the frequency of PD-1 expression decreased compared with that of pre-cryoablation.In 11 patients with tumor recurrence,the frequency of PD-1 expression rose prominently compared to that of post-cryoablation.In both early-and intermediate-stage HCC patients,TFS and OS were shorter in patients with high expression of PD-1 compared with those with low expression of PD-1.Conclusions The expressions of circulating PD-1 increases with tumor progression.After argon-helium cryoablation,a reduction of PD-1 expression in HCC patients can be achieved.Increased expression of PD-1 may provide a reference for prediction of survival time in HCC patients after cryoablation.",
        "keywords": [
            "cryosurgery",
            "programmed death-1",
            "hepatocellular",
            "prognosis",
            "carcinoma"
        ],
        "authors": [
            {
                "name": "ZHOU Lin",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZENG Zhen",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "SHI Feng",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "ZHANG Min-na",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CHEN Yan",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "CHANG Xiu-juan",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LU Yin-ying",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "BAI Wen-lin",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "QU Jian-hui",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Chun-ping",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Hong",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LOU Min",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "WANG Fu-sheng",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "LV Ji-yun",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            },
            {
                "name": "YANG Yong-ping",
                "org": ".Center of Therapeutic Research for Hepatocellular Carcinoma,302 Hospital of PLA,Beijing ,China"
            }
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2011
    },
    "2mow8GdR": {
        "id": "2mow8GdR",
        "title": "Regulatory T cells are associated with post-cryoablation prognosis in patients with hepatitis B virus-related hepatocellular carcinoma.",
        "abstract": "We carried out this study to evaluate the association between regulatory T cells (Treg) and prognosis and progression after cryoablation in patients with hepatitis-B virus-related hepatocellular carcinoma.Peripheral Treg frequency in 111 patients with hepatocellular carcinoma (HCC) was detected by flow cytometry. Treg frequency and function were re-examined during patient follow up. A possible association between Treg and \u03b1-fetoprotein (AFP) was also analyzed, and the distribution of resident CD4(+) and CD8(+) T cells and FoxP3(+) T cells in the liver tissue of patients with HCC was examined by immunohistochemistry.Treg frequency significantly increased with disease progression. Our longitudinal study showed that Treg frequency had significantly decreased in 17 patients with HCC regression following cryoablation, but the frequency had dramatically increased in 14 patients with HCC recurrence or progression. Furthermore, AFP levels varied in a way comparable with Treg frequency in patients with elevated AFP recorded before therapy. Significantly increased suppressive effects of Treg on proliferation and cytokine secretion of CD8(+) and CD4(+) T cells were observed during follow up in patients with tumor progression, but not in patients with tumor response. Moreover, the numbers of CD8(+), CD4(+), and FoxP3(+) cells infiltrating the tumors around the cryotherapeutic zones were significantly decreased after argon-helium cryoablation, and this was associated with a reduction in the FoxP3/CD8 ratio. Importantly,increased quantities of circulating CD4(+)CD25(+)FoxP3(+) Treg and tumor infiltrating FoxP3(+) cells before cryoablation were associated with high recurrence or risk of progression in HCC patients after cryoablation.Treg variation is associated with tumor regression or progression in HCC following cryoablation and may be used as a marker to estimate HCC progression.",
        "keywords": [
            "hepatocellular carcinoma cryoablation regulatory t cell prognosis",
            "cd8 t cell",
            "flow cytometry",
            "immunohistochemistry"
        ],
        "authors": [
            {
                "name": "Lin Zhou",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Jun-Liang Fu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Yin-Ying Lu",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Bao-Yun Fu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Chun-Ping Wang",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Lin-Jing An",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Xin-Zhen Wang",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Zhen Zeng",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Chun-Bao Zhou",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Yong-Ping Yang",
                "org": "Center of Therapeutic Research for Hepatocellular Carcinoma, Beijing 302 Hospital, Beijing, 100039 China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing, 100039 China"
            }
        ],
        "venue": "Journal of gastroenterology",
        "year": 2010
    },
    "Ym3F94Cg": {
        "id": "Ym3F94Cg",
        "title": "Progressive CD127 down-regulation correlates with increased apoptosis of CD8 T cells during chronic HIV-1 infection.",
        "abstract": "Chronic HIV-1 infection can induce a significant decrease in CD127 expression on CD8 T cells, but the underlying mechanisms and immunological consequences are unclear. In this study, we investigated CD127 expression on CD8 T cells from a total of 51 HIV-1-infected subjects and 16 healthy individuals and analyzed the association between CD127 expression and CD8 T-cell apoptosis in these HIV-1-infected subjects. We found that CD127 expression on total CD8 T cells was significantly down-regulated, which was correlated with the increased CD8 T-cell apoptosis and disease progression of chronic HIV-1 infection. The in vitro addition of IL-7 efficiently rescued the spontaneous apoptosis of CD8 T cells from HIV-1-infected individuals. IL-7 stimulation also transiently down-regulated CD127 expression, whereas some of the CD127(-) CD8 T cells regained CD127 expression soon after IL-7 was retracted from the incubation medium. Thus, IL-7 stimulation reduced apoptosis of both CD127(+) and CD127(-)CD8 T cells to some degree. These data indicate that CD127 loss might impair IL-7 signaling and increase CD8 T-cell apoptosis during HIV-1 infection. This study, therefore, will extend the notion that IL-7 could be a good candidate for immunotherapy in HIV-1-infected patients.",
        "keywords": [
            "apoptosis",
            "cd127",
            "cd8 t cells",
            "hiv-1",
            "gene expression",
            "interleukins",
            "cd8 t cell"
        ],
        "authors": [
            {
                "name": "Shu-Ye Zhang",
                "org": ""
            },
            {
                "name": "Zheng Zhang",
                "org": ""
            },
            {
                "name": "Jun-Liang Fu",
                "org": ""
            },
            {
                "name": "Fu-Biao Kang",
                "org": ""
            },
            {
                "name": "Xiang-Sheng Xu",
                "org": ""
            },
            {
                "name": "Wei-Min Nie",
                "org": ""
            },
            {
                "name": "Chun-Bao Zhou",
                "org": ""
            },
            {
                "name": "Min Zhao",
                "org": ""
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "European journal of immunology",
        "year": 2009
    },
    "gbDprUP8": {
        "id": "gbDprUP8",
        "title": "Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseases.",
        "abstract": "",
        "keywords": [
            "molecular",
            "cell differentiation",
            "mesenchymal stem cell",
            "immunogenetics",
            "clinical trial",
            "neuroimmunology",
            "immunology",
            "innate immunity",
            "adaptive immunity",
            "apoptosis",
            "cell proliferation",
            "mesenchymal stromal cells"
        ],
        "authors": [
            {
                "name": "hu lin",
                "org": ""
            },
            {
                "name": "ruonan xu",
                "org": ""
            },
            {
                "name": "zheng zhang",
                "org": ""
            },
            {
                "name": "liming chen",
                "org": ""
            },
            {
                "name": "ming shi",
                "org": ""
            },
            {
                "name": "fusheng wang",
                "org": ""
            }
        ],
        "venue": "Cellular & Molecular Immunology",
        "year": 2011
    },
    "qOJRepVI": {
        "id": "qOJRepVI",
        "title": "Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection.",
        "abstract": "Adoptive immune transfer plays an important role in clearance of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this study, functional CIK cells were efficiently generated from 21 CHB patients and were transfused in an autologous manner. We found that CIK cells from the CHB patients displayed substantial proliferation and function. Administration of the CIK cells closely correlated with the decrease in the serum HBV load and improvement in liver function in some patients. The virological response rate in patients with baseline serum alanine aminotransferase (ALT) levels of >40 U/L was higher than that in patients with baseline serum ALT levels of < or = 40 U/L. Moreover, patients who had HBeAg loss or showed seroconversion generally had baseline serum ALT levels of >40 U/L. No serious side effects were observed. This protocol represents an alternative immune therapeutic strategy for the disease.",
        "keywords": [
            "efficacy",
            "cytokine-induced killer cell",
            "safety",
            "hepatitis b virus",
            "chronic hepatitis b",
            "side effect",
            "drug resistance",
            "immune response",
            "viral replication"
        ],
        "authors": [
            {
                "name": "Ming Shi",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Junliang Fu",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Feng Shi",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Bin Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Zirong Tang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Lei Jin",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Zhenping Fan",
                "org": "The 6th Clinical Department, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Zheng Zhang",
                "org": "Research Center for Biological Therapy, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Liming Chen",
                "org": "The 6th Clinical Department, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "Huifeng Wang",
                "org": "The 6th Clinical Department, Beijing 302 Hospital, Beijing 100039, China"
            },
            {
                "name": "George K.K. Lau",
                "org": "Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong SAR, China"
            },
            {
                "name": "Fu-Sheng Wang",
                "org": ""
            }
        ],
        "venue": "Clinical immunology (Orlando, Fla.)",
        "year": 2009
    },
    "28O3ftx5": {
        "authors": [
            {
                "name": "T.K. Ku",
                "org": "Dept. of Electronics Engineering"
            },
            {
                "name": "S.H. Chen",
                "org": "Inst. of Mat. Sci. and Engineering"
            },
            {
                "name": "C.D. Yang",
                "org": "Dept. of Electronics Engineering"
            },
            {
                "name": "N.J. She",
                "org": "Inst. of Mat. Sci. and Engineering"
            },
            {
                "name": "F.G. Tarntair",
                "org": "Dept. of Electronics Engineering"
            },
            {
                "name": "C.C. Wang",
                "org": "Dept. of Electronics Engineering"
            },
            {
                "name": "C.F. Chen",
                "org": "Inst. of Mat. Sci. and Engineering"
            },
            {
                "name": "I.J. Hsieh",
                "org": "Department of Electrical Engineering"
            },
            {
                "name": "H.C. Cheng",
                "org": "Dept. of Electronics Engineering"
            }
        ],
        "title": "Enhanced electron emission from phosphorus- and boron-doped diamond-clad Si field emitter arrays",
        "abstract": "A new fabrication technology of polycrystalline diamond-clad Si microtips using microwave plasma chemical vapordeposition (MPCVD) has been developed to improve the characteristics of electron field emission from the pure Si tips. A uniform and smooth coating morphology for the diamond-clad Si tips have been achieved. Electron emission currents of diamond-clad tips are much higher than those of pure Si tips. Such great improvement is attributed to the lowering of the effective work function in the diamond-clad tips. The effects of phosphorus- and boron-doped diamond-clad Si tips have been also studied in comparison with the undoped ones. The current-voltage characteristics of the undoped diamond-clad tips were further enhanced by the in-situ doping of phosphorus or boron due to a higher electron supplement. Moreover, the P-doped diamond-clad tips show a better field emission performance as compared to the B-doped ones. This difference is surmised to be associated with the higher electron conductivity and defect densities of P-doped diamond films.",
        "keywords": [
            "Diamond-clad Silicon tips",
            "Effective work function",
            "Field emission",
            "Field emitter arrays"
        ],
        "venue": "Thin Solid Films",
        "year": 1996,
        "id": "28O3ftx5"
    },
    "BoAzVJzb": {
        "authors": [
            {
                "name": "T.K. Ku",
                "org": "National Chiao Tung University"
            },
            {
                "name": "S.H. Chen",
                "org": "National Chiao Tung University"
            },
            {
                "name": "C.D. Yang",
                "org": "National Chiao Tung University"
            },
            {
                "name": "N.J. She",
                "org": "National Chiao Tung University"
            },
            {
                "name": "C.C. Wang",
                "org": "National Chiao Tung University"
            },
            {
                "name": "C.F. Chen",
                "org": "National Chiao Tung University"
            },
            {
                "name": "I.J. Hsieh",
                "org": "Chung-Hua Polytecnic Institute"
            },
            {
                "name": "H.C. Cheng",
                "org": "National Chiao Tung University"
            }
        ],
        "title": "Enhanced electron emission from phosphorus-doped diamond-clad silicon field emitter arrays",
        "abstract": "Undoped and phosphorus (P)-doped diamond-clad Si field emitter arrays have been successfully fabricated using microwave plasma chemical vapor deposition (MPCVD) technology. The electron emission from the blunt diamond-clad microtips are much higher than those for the pure Si tips with sharp curvature due to a lower work function. Furthermore, the characteristics of emission current against applied voltage for the P-doped diamond-clad tips show superior emission at lower field to the undoped ones. After the examination of Auger electron spectroscopy (AES) and electrical characteristics of as-grown diamond, such a significant enhancement of the electron emission from the P-doprd diamond-clad tips is attributed to a higher electron conduction and defect densities.",
        "keywords": [
            ""
        ],
        "venue": "IEEE Electron Device Letters",
        "year": 1996,
        "id": "BoAzVJzb"
    },
    "8m90ODOd": {
        "authors": [
            {
                "name": "B.-C. Su",
                "org": "Department of Anesthesiology, Chang Gung Memorial Hospital"
            },
            {
                "name": "C.-F. Luo",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            },
            {
                "name": "W.-Y. Chang",
                "org": "Department of Anesthesiology, Chang Gung Memorial Hospital"
            },
            {
                "name": "W.-C. Lee",
                "org": "Department of General Surgery, Chang Gung Memorial Hospital"
            },
            {
                "name": "C.-C. Lin",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            }
        ],
        "title": "Corrected flow time is a good indicator for preload responsiveness during living donor liver donation",
        "keywords": [
            ""
        ],
        "venue": "Transplantation Proceedings",
        "year": 2014,
        "id": "8m90ODOd"
    },
    "pyiZc94D": {
        "authors": [
            {
                "name": "T.-W. Lin",
                "org": "Department of Anesthesiology, Chang Gung Memorial Hospital-Linkou"
            },
            {
                "name": "C.-F. Luo",
                "org": "Department of Anesthesiology, Chang Gung Memorial Hospital-Linkou"
            },
            {
                "name": "C.-C. Lin",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            },
            {
                "name": "W.-C. Lee",
                "org": "Division of Transplantation and Liver Surgery, Department of General Surgery, Chang Gung Memorial Hospital-Linkou"
            },
            {
                "name": "B.-C. Su",
                "org": "Department of Anesthesiology, Chang Gung Memorial Hospital-Linkou"
            }
        ],
        "title": "Utilization of bioreactance technique as indicator for preload responsiveness during living donor liver donation",
        "keywords": [
            ""
        ],
        "venue": "Transplantation Proceedings",
        "year": 2014,
        "id": "pyiZc94D"
    },
    "4vf4z2YP": {
        "authors": [
            {
                "name": "W.-C. Sung",
                "org": ""
            },
            {
                "name": "H.-P. Yu",
                "org": ""
            },
            {
                "name": "Y.-F. Tsai",
                "org": ""
            },
            {
                "name": "P.C.-H. Chung",
                "org": ""
            },
            {
                "name": "C.-C. Lin",
                "org": ""
            },
            {
                "name": "W.-C. Lee",
                "org": ""
            }
        ],
        "title": "The ratio of plasma interleukin-18 is a sensitive biomarker for acute kidney injury after liver transplantation",
        "keywords": [
            ""
        ],
        "venue": "Transplantation Proceedings",
        "year": 2014,
        "id": "4vf4z2YP"
    },
    "YEW3KILP": {
        "authors": [
            {
                "name": "Y.-F. Tsai",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            },
            {
                "name": "F.-C. Liu",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            },
            {
                "name": "W.-C. Sung",
                "org": "Department of Anesthesiology, Chang Gung Memorial Hospital"
            },
            {
                "name": "C.-C. Lin",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            },
            {
                "name": "P.C.-H. Chung",
                "org": "College of Medicine, Chang Gung University"
            },
            {
                "name": "W.-C. Lee",
                "org": "Division of Transplantation and Liver Surgery, Department of General Surgery, Chang Gung Memorial Hospital"
            },
            {
                "name": "H.-P. Yu",
                "org": "Graduate Institute of Clinical Medical Sciences, Chang Gung University"
            }
        ],
        "title": "Ischemic reperfusion injury-induced oxidative stress and pro-inflammatory mediators in liver transplantation recipients",
        "keywords": [
            ""
        ],
        "venue": "Transplantation Proceedings",
        "year": 2014,
        "id": "YEW3KILP"
    },
    "cjNfDQHn": {
        "authors": [
            {
                "name": "C.-M. Hung",
                "org": ""
            },
            {
                "name": "C.-C. Huang",
                "org": ""
            },
            {
                "name": "L.-B. Jeng",
                "org": ""
            },
            {
                "name": "W.-C. Lee",
                "org": ""
            },
            {
                "name": "M.-C. Yu",
                "org": ""
            },
            {
                "name": "C.-C. Lin",
                "org": ""
            },
            {
                "name": "M.-H. Shyr",
                "org": ""
            }
        ],
        "title": "Impaired renal function after liver transplantation: Role of rhabdomyoglobinuria",
        "keywords": [
            ""
        ],
        "venue": "Transplantation Proceedings",
        "year": 2000,
        "id": "cjNfDQHn"
    },
    "nEzM2hmG": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": ""
            },
            {
                "name": "Wei Liu",
                "org": ""
            },
            {
                "name": "Jun Yin",
                "org": ""
            },
            {
                "name": "Jun-Le Qu",
                "org": ""
            },
            {
                "name": "Zi-Yang Lin",
                "org": ""
            },
            {
                "name": "Han-Ben Niu",
                "org": ""
            }
        ],
        "title": "Optimization of supercontinuum sources for ultra-broadband T-CARS spectroscopy",
        "abstract": "For a typical photonic crystal fiber with two zero-dispersion wavelengths, we theoretically demonstrate a new way to generate supercontinuum using an input pulse of 30 fs duration and 10 kW peak power for providing a compact and cost effective light source to the ultra-broadband time-resolved coherent anti-Stokes Raman scattering spectroscopy. \u00a9 2011 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            ""
        ],
        "venue": "Chinese Physics Letters",
        "year": 2011,
        "id": "nEzM2hmG"
    },
    "AFFYY8Bs": {
        "authors": [
            {
                "name": "Jun Yin",
                "org": ""
            },
            {
                "name": "Ziyang Lin",
                "org": ""
            },
            {
                "name": "Junle Qu",
                "org": ""
            },
            {
                "name": "Lingyao Yu",
                "org": ""
            },
            {
                "name": "Xing Liu",
                "org": ""
            },
            {
                "name": "Hui Wan",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            }
        ],
        "title": "Coherent anti-stokes Raman scattering microscopic imaging technique",
        "abstract": "In this paper, theoretical and technical development of coherent anti-Stokes Raman scattering (CARS) microscopy is reviewed. The requirements of CARS microscopy on the pump laser source and typical experimental instrumentation are discussed and compared. We investigate the non-resonance background noise which is the most critical problem and can not be avoided in the CARS microscopy. Different methods for suppressing non-resonant background noise are presented and compared. Finally, a brief analysis of existing problems in CARS microscopy and possible solutions is presented.",
        "keywords": [
            "Coherent anti-Stokes Raman scattering",
            "Laser optics",
            "Microscopic imaging method",
            "Non-resonance background noise",
            "Photonic crystal fiber",
            "Supercontinuum"
        ],
        "venue": "Zhongguo Jiguang/Chinese Journal of Lasers",
        "year": 2009,
        "id": "AFFYY8Bs"
    },
    "nmciqlPj": {
        "authors": [
            {
                "name": "Jun Yin",
                "org": ""
            },
            {
                "name": "Ling-Yao Yu",
                "org": ""
            },
            {
                "name": "Xing Liu",
                "org": ""
            },
            {
                "name": "Hui Wan",
                "org": ""
            },
            {
                "name": "Zi-Yang Lin",
                "org": ""
            },
            {
                "name": "Han-Ben Niu",
                "org": ""
            }
        ],
        "title": "Simultaneous measurements of global vibrational spectra and dephasing times of molecular vibrational modes by broadband time-resolved coherent anti-Stokes Raman scattering spectrography",
        "abstract": "In broadband coherent anti-Stokes Raman scattering (CARS) spectroscopy with supercontinuum (SC), the simultaneously detectable spectral coverage is limited by the spectral continuity and the simultaneity of various spectral components of SC in an enough bandwidth. By numerical simulations, the optimal experimental conditions for improving the SC are obtained. The broadband time-resolved CARS spectrography based on the SC with required temporal and spectral distributions is realised. The global molecular vibrational spectrum with well suppressed nonresonant background noise can be obtained in a single measurement. At the same time, the measurements of dephasing times of various molecular vibrational modes can be conveniently achieved from intensities of a sequence of time-resolved CARS signals. It will be more helpful to provide a complete picture of molecular vibrations, and to exhibit a potential to understand not only both the solvent dynamics and the solute-solvent interactions, but also the mechanisms of chemical reactions in the fields of biology, chemistry and material science. \u00a9 2011 Chinese Physical Society and IOP Publishing Ltd.",
        "keywords": [
            "coherent anti-Stokes Raman scattering",
            "dephasing time",
            "molecular vibrational spectrum",
            "photonic crystal fibre",
            "supercontinuum",
            "time-resolved measurement"
        ],
        "venue": "Chinese Physics B",
        "year": 2011,
        "id": "nmciqlPj"
    },
    "odOrU70L": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": "Key Laboratory of Optoelectronic Devices"
            },
            {
                "name": "Hanben Niu",
                "org": "Key Laboratory of Optoelectronic Devices"
            },
            {
                "name": "Wei Liu",
                "org": "Key Laboratory of Optoelectronic Devices"
            },
            {
                "name": "Danni Chen",
                "org": "Key Laboratory of Optoelectronic Devices"
            },
            {
                "name": "Binbin Zhou",
                "org": "Technical University of Denmark"
            },
            {
                "name": "Morten Bache",
                "org": "Technical University of Denmark"
            }
        ],
        "title": "Completely background free broadband coherent anti-stokes Raman scattering spectroscopy",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Optics InfoBase Conference Papers",
        "year": 2013,
        "id": "odOrU70L"
    },
    "VUpHpATx": {
        "authors": [
            {
                "name": "Hui Wan",
                "org": ""
            },
            {
                "name": "Jun Yin",
                "org": ""
            },
            {
                "name": "Ling-Yao Yu",
                "org": ""
            },
            {
                "name": "Xing Liu",
                "org": ""
            },
            {
                "name": "Jun-Le Qu",
                "org": ""
            },
            {
                "name": "Zi-Yang Lin",
                "org": ""
            },
            {
                "name": "Han-Ben Niu",
                "org": ""
            }
        ],
        "title": "A method of obtaining vibrational dephasing time of molecular multi-vibrational modes simultaneously",
        "abstract": "In the present paper, the authors used the time-resolved coherent anti-Stokes Raman scattering (CARS) spectroscopy based on supercontinuum developed by ourselves to acquire simultaneously the molecular vibration spectrum and vibrational dephasing time of the molecular various vibrational modes. Using benzonitrile as the sample, the authors measured its vibrational relaxation processes at its five typical vibrational modes and obtained their vibrational dephasing time respectively. In the experiment, the authors also found the phenomenon that oscillations appear in the vibrational dephasing of plane bending vibration mode of benzene ring in benzonitrile, which was caused by superposition of the two adjacent normal vibrational modes excited simultaneously. After mixing benzonitrile with anhydrous ethanol, the authors also measured their vibrational dephasing time. This method is capable of monitoring the changes of the molecular characteristics and its micro-environment, therefore it will find widespread applications in biology, chemistry and materials science.",
        "keywords": [
            "Coherent anti-Stokes Raman scattering",
            "Molecular vibrational spectrum",
            "Time-resolved method",
            "Vibrational dephasing time"
        ],
        "venue": "Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis",
        "year": 2011,
        "id": "VUpHpATx"
    },
    "PjweRFM0": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Hanben Niu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Wei Liuc",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Danni Chen",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Binbin Zhou",
                "org": "Technical University of Denmark"
            },
            {
                "name": "Morten Bache",
                "org": "Technical University of Denmark"
            }
        ],
        "title": "Cross-correlation frequency-resolved optical gating by molecular vibration for ultrashort pulse",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Optics InfoBase Conference Papers",
        "year": 2013,
        "id": "PjweRFM0"
    },
    "vXgrD5hu": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": ""
            },
            {
                "name": "Hanben Niu",
                "org": ""
            },
            {
                "name": "Wei Liuc",
                "org": ""
            },
            {
                "name": "Danni Chen",
                "org": ""
            },
            {
                "name": "Binbin Zhou",
                "org": ""
            },
            {
                "name": "Morten Bache",
                "org": ""
            }
        ],
        "title": "Cross-correlation frequency-resolved optical gating by molecular vibration for ultrashort pulse",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Optics InfoBase Conference Papers",
        "year": 2013,
        "id": "vXgrD5hu"
    },
    "FnSrqgBF": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Hanben Niu",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Wei Liu",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Danni Chen",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Binbin Zhou",
                "org": "Technical University of Denmark, DTU Fotonik, Dept. of Photonics Engineering"
            },
            {
                "name": "Morten Bache",
                "org": "Technical University of Denmark, DTU Fotonik, Dept. of Photonics Engineering"
            }
        ],
        "title": "Completely background free broadband coherent anti-Stokes Raman scattering spectroscopy",
        "abstract": "3-color coherent anti-Stokes Raman scattering (CARS) can be used to measure the dynamics of vibrationally excited states by controlling the time delay between the broadband and narrowband pulses. It is promising to simultaneously obtain the CARS spectra in time-frequency domains and monitor vibration dephasing times of multiple Raman modes, which is especially favourable in the studies of molecular dynamics, supra-molecular structure, chemistry and material science [1]. However, the often present instantaneous nonresonant background (NRB) signal interferes with and typically dominates the much weaker resonant signals, leading to significant reduction [2]. \u00a9 2013 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "2013 Conference on Lasers and Electro-Optics Europe and International Quantum Electronics Conference, CLEO/Europe-IQEC 2013",
        "year": 2013,
        "id": "FnSrqgBF"
    },
    "ZY3Jr3iz": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Hanben Niu",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Wei Liu",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Danni Chen",
                "org": "Systems of Ministry of Education and Guangdong Province, Institute of Optoelectronics, Shenzhen University"
            },
            {
                "name": "Binbin Zhou",
                "org": "Technical University of Denmark, DTU Fotonik, Dept. of Photonics Engineering"
            },
            {
                "name": "Morten Bache",
                "org": "Technical University of Denmark, DTU Fotonik, Dept. of Photonics Engineering"
            }
        ],
        "title": "Cross-correlation frequency-resolved optical gating by molecular vibration for ultrashort pulse",
        "abstract": "The frequency-resolved optical gating (FROG) technique is one of the most popular and robust methods for ultrashort laser pulse characterization [1], which involves an experimental apparatus to create a spectrogram of a target pulse resulting from its convolution with a gate function and a retrieval algorithm. \u00a9 2013 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "2013 Conference on Lasers and Electro-Optics Europe and International Quantum Electronics Conference, CLEO/Europe-IQEC 2013",
        "year": 2013,
        "id": "ZY3Jr3iz"
    },
    "1qQ0e9T7": {
        "authors": [
            {
                "name": "Ling-Yao Yu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Jun Yin",
                "org": "College of Optoelectronic Science and Engineering"
            },
            {
                "name": "Hui Wan",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Xing Liu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Jun-Le Qu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Han-Ben Niu",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            },
            {
                "name": "Zi-Yang Lin",
                "org": "Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province"
            }
        ],
        "title": "Study on the method and experiment of time-resolved coherent anti-Stokes Raman scattering using supercontinuum excitation",
        "abstract": "In this paper, we present the development and experimental results of a time-resolved coherent anti-Stokes Raman scattering (CARS) experiment setup that is based on supercontinuum excitation and precise time-delay control. The output of a Ti-sapphire femtosecond laser is divided into two parts. One part is used to pump a photonic crystal fiber (PCF) to generate supercontinuum spectrum which is used as pump and stokes beams. The other part of the femtosecond laser is used as the probe light. Dimethyl sulfoxid, a sample with broad range of Raman spectrum was tested. Experimental results show that this system can inhibit the non-resonant background noise effectively and obtain CARS spectrum of dimethyl sulfoxide in the frequency range of 690-3200 cm",
        "keywords": [
            "Coherent anti-Stokes Raman scattering",
            "Photonic crystal fiber",
            "Supercontinuum spectrum",
            "Time-resolved"
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2010,
        "id": "1qQ0e9T7"
    },
    "hB5EDFRX": {
        "id": "hB5EDFRX",
        "title": "Facile synthesis of a novel full-spectrum-responsive Co2.67S4 nanoparticles for UV-, vis- and NIR-driven photocatalysis",
        "abstract": "Abstract   Sparked by growing pollution issues, research aiming at a better harvesting of solar energy in photocatalysts for environmental remediation has been thriving. In this study, a novel mixed valence state of Co 2.67 S 4  nanoparticles with full-spectrum-responsive photocatalytic activity had been fabricated via a facile solvothermal route. The as-synthesized samples were systematically characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and UV\u2013vis-NIR diffuse reflection spectroscopy (UV\u2013vis-NIR DRS). The photocatalytic performance of as-obtained samples had been investigated by the degradation of methylene blue (MB) in aqueous solution. The Co 2.67 S 4  nanoparticles with the particle size of 5\u201320\u00a0nm could degrade MB with the efficiency of 64%, 84% and 68% under the UV light, visible light and near-infrared light exposure, respectively. Furthermore, a possible photocatalytic mechanism toward the near-infrared region had been proposed to be that the Co 2+ /Co 3+  redox couple played vital parts in the photocatalytic activity of Co 2.67 S 4 . This study provides a novel full solar spectrum-responsive photocatalyst for solar-light utility and environmental remediation.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhenzhen Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Lei Zhang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Zhihua Xiao",
                "org": "College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, PR China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Hunan University of Commerce, Changsha 410205, PR China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Applied Catalysis B-environmental",
        "year": 2017
    },
    "yRb22Eqr": {
        "id": "yRb22Eqr",
        "title": "Novel cavitation fluid jet polishing process based on negative pressure effects.",
        "abstract": "Traditional abrasive fluid jet polishing (FJP) is limited by its high-pressure equipment, unstable material removal rate, and applicability to ultra-smooth surfaces because of the evident air turbulence, fluid expansion, and a large polishing spot in high-pressure FJP. This paper presents a novel cavitation fluid jet polishing (CFJP) method and process based on FJP technology. It can implement high-efficiency polishing on small-scale surfaces in a low-pressure environment. CFJP uses the purposely designed polishing equipment with a sealed chamber, which can generate a cavitation effect in negative pressure environment. Moreover, the collapse of cavitation bubbles can spray out a high-energy microjet and shock wave to enhance the material removal. Its feasibility is verified through researching the flow behavior and the cavitation results of the negative pressure cavitation machining of pure water in reversing suction flow. The mechanism is analyzed through a computational fluid dynamics simulation. Thus, its cavitation and surface removal mechanisms in the vertical CFJP and inclined CFJP are studied. A series of polishing experiments on different materials and polishing parameters are conducted to validate its polishing performance compared with FJP. The maximum removal depth increases, and surface roughness gradually decreases with increasing negative outlet pressures. The surface becomes smooth with the increase of polishing time. The experimental results confirm that the CFJP process can realize a high material removal rate and smooth surface with low energy consumption in the low-pressure environment, together with compatible surface roughness to FJP.",
        "keywords": [
            "Abrasive jet",
            "Cavitation bubble",
            "Cavitation fluid jet polishing",
            "Computational fluid dynamic",
            "Material removal",
            "Negative pressure"
        ],
        "authors": [
            {
                "name": "Fengjun Chen",
                "org": "National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, Hunan, China. Electronic address: abccfj@126.com."
            },
            {
                "name": "Hui Wang",
                "org": "National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, Hunan, China."
            },
            {
                "name": "Yu Tang",
                "org": "National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, Hunan, China."
            },
            {
                "name": "Shaohui Yin",
                "org": "National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, Hunan, China."
            },
            {
                "name": "Shuai Huang",
                "org": "National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, Hunan, China."
            },
            {
                "name": "Guanghua Zhang",
                "org": "National Engineering Research Center for High Efficiency Grinding, Hunan University, Changsha 410082, Hunan, China."
            }
        ],
        "venue": "Ultrasonics sonochemistry",
        "year": 2018
    },
    "hg3rCvzt": {
        "id": "hg3rCvzt",
        "title": "Modified stannous sulfide nanoparticles with metal-organic framework: Toward efficient and enhanced photocatalytic reduction of chromium (VI) under visible light.",
        "abstract": "Novel metal-organic framework/stannous sulfide (MIL-53(Fe)/SnS) nanocomposite photocatalysts were successfully synthesized by a one-step deposition process. The structure, composition and optical properties of the MIL-53(Fe)/SnS composite were systematically characterized by the X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, Fourier transform-infrared spectroscopy, UV-vis diffuse reflection spectroscopy and photoluminescence analysis. The photocatalytic performance of MIL-53(Fe)/SnS composite has been evaluated in the reduction of chromium (VI) under visible-light irradiation. Compared with pure MIL-53(Fe) and SnS, the MIL-53(Fe)/SnS composite exhibited enhanced photoreduction capability of chromium (VI) due to the strengthened absorption in the visible region, higher electron-hole separation rate and larger specific area. The MIL-53(Fe)/SnS composite with MIL-53(Fe) adding of 15\u202fmg displayed optimal chromium (VI) reduction rate of 0.01878\u202fmin, which was about 7.5 and 5.2 times than pure MIL-53(Fe) and SnS, respectively. The active species superoxide radical (O), electron(e) and hole(h) are essential toward chromium (VI) reduction. Lastly, a possible photocatalytic mechanism is proposed.",
        "keywords": [
            "Chromium (VI)",
            "MIL-53(Fe)",
            "Photocatalysis",
            "SnS",
            "Visible light irradiation"
        ],
        "authors": [
            {
                "name": "Qi Xia",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Binbin Huang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China. Electronic address: binbinhuang@hnu.edu.cn."
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China. Electronic address: yxz@hnu.edu.cn."
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Ting Xiong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Jin Zhang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environment Biology and Pollution Control, Hunan University, Ministry of Education, Changsha 410082, PR China; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore. Electronic address: huankewanghou024@163.com."
            }
        ],
        "venue": "Journal of colloid and interface science",
        "year": 2018
    },
    "pqHMprqu": {
        "id": "pqHMprqu",
        "title": "Highly efficient photocatalytic activity and mechanism of Yb 3+ /Tm 3+ codoped In 2 S 3 from ultraviolet to near infrared light towards chromium (VI) reduction and rhodamine B oxydative degradation",
        "abstract": "\u2022   The highly full-spectrum-active Yb 3+ /Tm 3+  codoped In 2 S 3  photocatalyst was synthesized.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhibin Wu",
                "org": ""
            },
            {
                "name": "Xingzhong Yuan",
                "org": ""
            },
            {
                "name": "Guangming Zeng",
                "org": ""
            },
            {
                "name": "Longbo Jiang",
                "org": ""
            },
            {
                "name": "Hua Zhong",
                "org": ""
            },
            {
                "name": "Yingcong Xie",
                "org": ""
            },
            {
                "name": "Hui Wang",
                "org": ""
            },
            {
                "name": "Xiaohong Chen",
                "org": ""
            },
            {
                "name": "Hou Wang",
                "org": ""
            },
            {
                "name": "Hou Wang",
                "org": ""
            }
        ],
        "venue": "Applied Catalysis B-environmental",
        "year": 2018
    },
    "YB0vkiIX": {
        "id": "YB0vkiIX",
        "title": "Near-infrared-driven Cr(VI) reduction in aqueous solution based on a MoS2/Sb2S3 photocatalyst",
        "abstract": "Exploiting photocatalysts with a full spectrum response undoubtedly holds great potential. Here, a novel MoS2/Sb2S3 composite with a wide-range photoresponse was fabricated through a facile hydrothermal method. The as-obtained photocatalyst was characterized via a variety of techniques used for analyzing morphology, structure, and physical\u2013chemical and photoelectrochemical properties. It was indicated that the MoS2/Sb2S3 hybrid possessed fast electron transport and improved light absorption. Additionally, the composite presents remarkable photoelectric conversion efficiency and optimal MoS2/Sb2S3 could remove Cr(VI) with efficiencies of 84%, 99% and 72% when exposed to ultraviolet, visible and near-infrared (NIR) light, which are 16, 50 and 25 times greater than those of Sb2S3, respectively. The enhanced NIR photocatalytic efficiency may be explained by the enhanced NIR light absorption, favorable charge separation and, in particular, the sulfur vacancies in MoS2.",
        "keywords": "",
        "authors": [
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Junjie Wang",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information system, National University of Defense Technology,Changsha,P.R. China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Hunan University of Commerce,Changsha 410205,PR China"
            },
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Ting Xiong",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Jin Zhang",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University,Changsha 410082,P.R. China"
            }
        ],
        "venue": "Catalysis Science & Technology",
        "year": 2018
    },
    "ipldrmns": {
        "id": "ipldrmns",
        "title": "Metal-free efficient photocatalyst for stable visible-light photocatalytic degradation of refractory pollutant",
        "abstract": "Abstract   The photocatalytic performance of the star photocatalyst g-C 3 N 4  is restricted by the insufficient solar light absorption, low surface area and the fast recombination of photogenerated electron-hole pairs. The present study developed a facile in situ method to construct hexagonal boron nitride (h-BN) decorated g-C 3 N 4  metal-free heterojunction with the aim to greatly enhance the surface area and promote the charge separation. The physical, chemical and optical properties of the resulted samples were thoroughly characterized. The photocatalytic performance of h-BN/g-C 3 N 4  composites were evaluated under visible light irradiation using antibiotic tetracycline (TC) and rhodamine B (RhB) as target pollutants. Results showed that h-BN/g-C 3 N 4  composites exhibited much higher photocatalytic activity than pure g-C 3 N 4  and h-BN. The optimum photocatalytic efficiency of BC-3 sample for the degradation of TC was about 2.3 and 60.3 times higher than that of individual g-C 3 N 4  and h-BN, respectively. Meanwhile, it was about 7.3 and 11.8 times higher than that of individual g-C 3 N 4  and h-BN for RhB degradation, respectively. The enhanced photocatalytic activity of h-BN/g-C 3 N 4  composite is mainly attributed to the larger surface area and the unique physicochemical properties of h-BN nanosheet which acts as a promoter for photoexcited holes transfer. This work indicates that the metal-free h-BN/g-C 3 N 4  hybrid photocatalyst is a promising material in wastewater control.",
        "keywords": "",
        "authors": [
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Jie Liang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Mobile E-business 2011 Collaborative Innovation Center of Hunan Province, Hunan University of Commerce, Changsha 410205, PR China"
            },
            {
                "name": "Lijian Leng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Applied Catalysis B-environmental",
        "year": 2018
    },
    "OKb4vfIU": {
        "id": "OKb4vfIU",
        "title": "Phosphorus- and Sulfur-Codoped g-C3N4: Facile Preparation, Mechanism Insight, and Application as Efficient Photocatalyst for Tetracycline and Methyl Orange Degradation under Visible Light Irradiation",
        "abstract": "Phosphorus- and sulfur-codoped graphitic carbon nitride has been successfully synthesized by in situ thermal copolymerization of hexachlorocyclotriphosphazene and thiourea. The phosphorus doping, together with the sulfur doping, would enhance light trapping, surface area, and charge separation, making it serve as a more efficient photocatalyst than its pure g-C3N4 and single-doped g-C3N4 counterpart for the removal of tetracycline (TC) and methyl orange (MO). The optimum photocatalytic activities of a P-, S-codoped g-C3N4 sample for the degradation of TC and MO were about 5.9 times and 7.1 times higher than that of individual g-C3N4, respectively. Furthermore, the optimum TOC removal reached 70.33% and 55.37% for TC and MO within 120 min, respectively. The introduction of a P atom and S atom could significantly change the electronic property of g-C3N4 and suppress the recombination of photogenerated charges. Moreover, the defects in the framework of samples caused by the doping of P and S could serve as c...",
        "keywords": "",
        "authors": [
            {
                "name": "Longbo Jiang",
                "org": ""
            },
            {
                "name": "Xingzhong Yuan",
                "org": ""
            },
            {
                "name": "Guangming Zeng",
                "org": ""
            },
            {
                "name": "Xiaohong Chen",
                "org": ""
            },
            {
                "name": "Zhibin Wu",
                "org": ""
            },
            {
                "name": "Jie Liang",
                "org": ""
            },
            {
                "name": "Jin Zhang",
                "org": ""
            },
            {
                "name": "Hui Wang",
                "org": ""
            },
            {
                "name": "Hou Wang",
                "org": ""
            }
        ],
        "venue": "ACS Sustainable Chemistry & Engineering",
        "year": 2017
    },
    "9pA1wRFD": {
        "id": "9pA1wRFD",
        "title": "Effects of single- and multi-organic acid ligands on adsorption of copper by Fe3O4/graphene oxide-supported DCTA.",
        "abstract": "The Fe3O4/graphene oxide-supported 1,2-diaminocyclohexanetetraacetic acid composite (Fe3O4/GO/DCTA) was used as an adsorbent for Cu(II) removal. The effects of six organic acid ligands (formate, acetate, benzoate, oxalate, tartrate, and edetate) on the adsorption process were investigated in single- and multi-ligand systems. The results demonstrated that the adsorption processes were affected by solution pH and ionic strength. The experimental data of kinetics and isotherm followed the pseudo-second-order model and the Langmuir model, respectively. In the single-ligand systems, the presence of formate, acetate, and benzoate slightly altered the Cu(II) adsorption property, while the adsorption processes were significantly affected by the oxalate, tartrate, and edetate ligands. In the multi-ligand systems, the Cu(II) adsorption was influenced by the type and concentration of organic acid ligands. The sequence of the main effect was found to be: edetate>oxalate>benzoate>formate>tartrate>acetate, and the sequence of the two-factor interaction effect was found to be: AE (formate\u00d7tartrate)>BF (acetate\u00d7edetate)>AF (formate\u00d7edetate)>BD (acetate\u00d7oxalate)>AC (formate\u00d7benzoate)>AD (formate\u00d7oxalate)>AB (formate\u00d7acetate). ",
        "keywords": [
            "Graphene oxide",
            "Influence mechanism",
            "Interaction effect",
            "Multi-ligand system",
            "Organic acid ligands"
        ],
        "authors": [
            {
                "name": "Shaobo Liu",
                "org": "School of Metallurgy and Environment, Central South University, Changsha 410083, PR China; School of Architecture and Art, Central South University, Changsha 410083, PR China. Electronic address: liushaobo23@aliyun.com."
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China."
            },
            {
                "name": "Liyuan Chai",
                "org": "School of Metallurgy and Environment, Central South University, Changsha 410083, PR China."
            },
            {
                "name": "Meifang Li",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha 410082, PR China."
            }
        ],
        "venue": "Journal of colloid and interface science",
        "year": 2016
    },
    "fKF212b6": {
        "id": "fKF212b6",
        "title": "Highly efficient adsorption of Congo red in single and binary water with cationic dyes by reduced graphene oxide decorated NH2-MIL-68(Al)",
        "abstract": "Abstract   The reduced graphene oxide decorated NH 2 -MIL-68(Al) (RGO/NMA) is synthesized via one-pot solvothermal process and systematically characterized for the congo red (CR) removal from single and binary water with cationic dyes. The characterization results show that the surface area of negatively charged RGO/NMA is significantly enhanced by the introduction of reduced graphene oxide (RGO). The CR adsorption is investigated as a function of contact time, initial CR concentration, temperature, pH and ionic strength. It shows that the maximum CR adsorption capacity of RGO/NMA (473.93\u00a0mg/g) is 121% and 1337% higher than NH 2 -MIL-68(Al) (NMA) and RGO, respectively. The adsorption dynamic analysis shows that the Pseudo-second-order model presents the best fitting to CR adsorption compared with Pseudo-first-order and Elovich model. The adsorption rate-limited step is successively controlled by film-diffusion and intra-particle diffusion according to the applicability measurement of intra-particle diffusion, boydu0027s film-diffusion models and external mass transfer plots. Based on the suitability of isotherm models, the CR adsorption process can be described in order of Langmuir\u00a0u003e\u00a0Temkin\u00a0u003e\u00a0Freundlich\u00a0u003e\u00a0Hill. The adsorption mechanism involved the electrostatic attraction, \u03c0\u2013\u03c0 dispersion interaction and hydrogen bonds for the spontaneously exothermic adsorption process are indentified using the three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectrum The synergistic effect occurs in the simultaneous removal CR and cationic from water. The RGO/NMA has the excellent reusability and the resource utilization of CR loaded RGO/NMA as photocatalyst for Cr(VI) reduction under visible light irradiation is highly feasible.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hua Zhong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hua Zhong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore"
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Zhifeng Liu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Yifu Li",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Journal of Molecular Liquids",
        "year": 2017
    },
    "1hCr6i6C": {
        "id": "1hCr6i6C",
        "title": "Facile synthesis of Sb2S3/ultrathin g-C3N4 sheets heterostructures embedded with g-C3N4 quantum dots with enhanced NIR-light photocatalytic performance",
        "abstract": "Abstract   In recent years, exploiting novel photocatalysts with a broad range of wavelengths photoresponse is undoubtedly interesting in photocatalytic field. Here, a novel Sb 2 S 3 /ultrathin g-C 3 N 4  sheets heterostructures embedded with g-C 3 N 4  quantum dots (CNS) was successfully fabricated via a facile hydrothermal process. The samples were systematically characterized by the field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), UV\u2013vis-NIR diffuse reflection spectroscopy (UV-vis-NIR DRS) and photoluminescence (PL) spectroscopy. It is indicated that the composites have fast electron transport and enhanced solar light absorption. Moreover, the CNS composite exhibits a significant photoelectric conversion property in near-infrared (NIR) wavelength range. The photocatalytic activities of the samples were evaluated by the degradation of methyl orange (MO) upon NIR irradiation. The photodegradation rate of the optimal CNS for MO was 0.0103\u00a0min \u22121 , about 2.6 times higher than that of pure Sb 2 S 3 . The improved NIR photocatalytic activity may base on the improved absorption in the NIR region, efficient electron-hole separation and the up-converted PL property of g-C 3 N 4  quantum dots (CNQD).",
        "keywords": "",
        "authors": [
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Hunan University of Commerce, Changsha 410205, PR China"
            },
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Weiping Xiong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Applied Catalysis B-environmental",
        "year": 2016
    },
    "AWdRIF91": {
        "id": "AWdRIF91",
        "title": "Insight into highly efficient removal of cadmium and methylene blue by eco-friendly magnesium silicate-hydrothermal carbon composite",
        "abstract": "Abstract   Water pollution is one of the forefront environmental problems. Due to the simplification, flexibility and low cost, the adsorption becomes one of the most fashionable technology and the exploitation of adsorbents has drawn greatly attention. In this study, a novel magnesium silicate-hydrothermal carbon composite (MS-C) was synthesized by facile hydrothermal carbonization and used to remove the cadmium (Cd(II)) and methylene blue (MB) from wastewater. It was shown that the porous and lump-like magnesium silicate (MS) was decorated with multiple hydrothermal carbon (HC) via the C O Si covalent bonding. Further, the adsorption behavior of Cd(II) and MB based on the MS, HC, and MS-C were systematically investigated. The equilibrium data of both Cd(II) and MB were fitted well with Langmuir model. Compared to pure MS and HC, the adsorption capacity of composite was significantly improved, accompanied by the maximum adsorption capacity of 108\u00a0mg/g for Cd(II) and 418\u00a0mg/g for MB, respectively. In the Cd(II)\u2013MB binary system, the adsorption of Cd(II) was favored in comparison with that of MB. The removal of Cd(II) was mainly ascribed to electrostatic attraction and the ion exchange interaction. Meanwhile, the adsorption of MB onto adsorbent was driven by the electrostatic attraction, \u03c0-\u03c0 interaction and hydrogen bond. In view of these empirical results and real water treatment, the environmental friendly and low-cost MS-C holds a potential for separate or simultaneous removal of Cd(II) and MB in practical applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Ting Xiong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xiaohong Chen",
                "org": "Mobile E-business 2011 Collaborative Innovation Center of Hunan Province, Hunan University of Commerce, Changsha 410205, PR China"
            },
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Lijian Leng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2018
    },
    "amVNUofl": {
        "id": "amVNUofl",
        "title": "Effective removal of high-chroma rhodamine B over Sn 0.215 In 0.38 S/reduced graphene oxide composite: Synergistic factors and mechanism of adsorption enrichment and visible photocatalytic degradation",
        "abstract": "Abstract   The highly visible light active Sn 0.215 In 0.38 S/reduced graphene oxide (SIS/RGO) composites with hierarchical porous were prepared by a facil solvothermal in-situ growth method for rhodamine B (RhB) removal coupling adsorption with photocatalysis. The morphology, composition and photocurrent response of the adsorptive photocatalysts were systematically characterized. The investigation results showed that both adsorption and photocatalytic processes were affected by pH, ionic strength and so on. The RhB adsorption process complied with pseudo-second order kinetics equation and Langmuir isotherm model, and the SIS/RGO-2.5% showed the optimum adsorption-photocatalytic performance. The maximum adsorption capacity of SIS/RGO-2.5% was 173.97\u202fmg\u00b7g \u22121  mainly attributing to the electrostatic attraction, \u03c0\u202f\u2212\u202f\u03c0 interaction and surface complexation. Due to efficient mass transfer efficiency, dye self-sensitization and effective transfer of photogenerated carriers, the photodegradation efficiency of RhB over SIS/RGO-2.5% was as high as 96.25% under visible light irradiation for 25\u202fmin and the corresponding reaction rate constant is 3.98 times of Sn 0.215 In 0.38 S. The results of free radical capture and electron spin resonance experiments indicated that the  O 2  \u2212  and h +  were the main active species attacking RhB. Furthermore, cyclic experiments showed the considerable reusability and stability of photocatalysts for the RhB degradation.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhibin Wu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Xingzhong Yuan",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hua Zhong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hua Zhong",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hou Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Longbo Jiang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Lijian Leng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Guangming Zeng",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Zhifeng Liu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Powder Technology",
        "year": 2018
    },
    "lahAH4H2": {
        "id": "lahAH4H2",
        "title": "Ultrasensitive detection of microRNAs using catalytic hairpin assembly coupled with enzymatic repairing amplification.",
        "abstract": "A novel isothermal nucleic acid amplification technology is developed by coupling catalytic hairpin assembly with enzymatic repairing amplification as a highly sensitive and selective platform for miRNA detection.",
        "keywords": "",
        "authors": [
            {
                "name": "Chong-Hua Zhang",
                "org": "State Key Laboratory of Chemo-Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, China. jianhuijiang@hnu.edu.cn wuzhan1002@gmail.com."
            },
            {
                "name": "Ying Tang",
                "org": "State Key Laboratory of Chemo-Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, China. jianhuijiang@hnu.edu.cn wuzhan1002@gmail.com."
            },
            {
                "name": "Ying-Ying Sheng",
                "org": "State Key Laboratory of Chemo-Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, China. jianhuijiang@hnu.edu.cn wuzhan1002@gmail.com."
            },
            {
                "name": "Hui Wang",
                "org": "State Key Laboratory of Chemo-Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, China. jianhuijiang@hnu.edu.cn wuzhan1002@gmail.com."
            },
            {
                "name": "Zhan Wu",
                "org": "State Key Laboratory of Chemo-Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, China. jianhuijiang@hnu.edu.cn wuzhan1002@gmail.com."
            },
            {
                "name": "Jian-Hui Jiang",
                "org": "State Key Laboratory of Chemo-Biosensing & Chemometrics, College of Chemistry & Chemical Engineering, Hunan University, Changsha 410082, China. jianhuijiang@hnu.edu.cn wuzhan1002@gmail.com."
            }
        ],
        "venue": "Chemical communications (Cambridge, England)",
        "year": 2016
    },
    "N68FANGw": {
        "id": "N68FANGw",
        "title": "Facile synthesis of Bi2MoO6/ZnSnO3 heterojunction with enhanced visible light photocatalytic degradation of methylene blue",
        "abstract": "Abstract   In this paper, visible-light-driven Bi 2 MoO 6 /ZnSnO 3  (BMZ) hybrid photocatalysts were successful fabricated by a combined solvothermal (160\u00a0\u00b0C, 6\u00a0h) and annealing steps (450\u00a0\u00b0C, 1\u00a0h). Systematical characterization methods including X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM), X-ray diffraction (XRD), N 2  adsorption-desorption isotherms (BET), photoluminescence (PL) spectroscopy and ultraviolet-visible diffuse reflection spectroscopy (DRS) were implemented to further analyze the obtained hybrids. The photocatalytic properties were investigated against degrading methylene blue (MB) under visible light irradiation. Obviously, BMZ hybrid photocatalysts displayed better photocatalytic performance compared with the bare Bi 2 MoO 6  and ZnSnO 3 . Particularly, the highest photocatalytic activity was obtained by the 5-BMZ composite with the degradation efficiency of approximate 95%, which was up to 1.27 times and 7.31 times higher in comparison with pure Bi 2 MoO 6  and ZnSnO 3 , respectively. The superior photocatalytic performances may be derived from the formation of heterojunction and presence of active species including       O  2  \u2212      and h + . Finally, a possible photocatalytic mechanism for improved photocatalytic activity was proposed.",
        "keywords": "",
        "authors": [
            {
                "name": "Yue Liu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Zhao-Hui Yang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Peipei Song",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Rui Xu",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            },
            {
                "name": "Hui Wang",
                "org": "College of Environmental Science and Engineering, Hunan University, Changsha 410082, PR China"
            }
        ],
        "venue": "Applied Surface Science",
        "year": 2018
    },
    "stgHWIKo": {
        "authors": [
            {
                "name": "Zhao-Di Yang",
                "org": ""
            },
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Hong Zhao",
                "org": ""
            },
            {
                "name": "Baozhong Han",
                "org": ""
            }
        ],
        "title": "Trap mechanism based on frontier molecular orbitals of additives in polyethylene insulators: A theoretical study and molecular design strategy",
        "abstract": "In this work, the energy gaps (E<inf>g</inf>) of highest occupied orbitals and lowest unoccupied orbitals, trap energies (E<inf>t</inf>(e) and E<inf>t</inf>(h)) and excited energies of polyethylene model compound, typical defect compound, acetophonene, and 33 designed additives are obtained using density functional method at B3LYP/6-311+G(d, p) level. The correlation between trapping-electrons (holes) abilities of additives and molecular frontier orbitals is established, and a new understanding for trap mechanism based on chemical molecular orbital levels is given for the first time which could be used to filter qualitative additives as voltage stabilizers of polyethylene. The role of trap energies and the energy gaps on discussing space charge accumulation and electric breakdown is analyzed in detail. A molecular design strategy for potential additives of cross-linked polyethylene insulated high-voltage cable is shown based on conjugation effect, substituents character, and polycyclic aromatic compounds.",
        "keywords": [
            "aromatic carbonyl compounds",
            "frontier molecular orbitals",
            "trap mechanism"
        ],
        "venue": "International Journal of Quantum Chemistry",
        "year": 2015,
        "id": "stgHWIKo"
    },
    "1HgJvqGA": {
        "authors": [
            {
                "name": "Yanling Cui",
                "org": "Department of Physics"
            },
            {
                "name": "Hong Zhao",
                "org": "Measurement and Testing Institute of Mongolian Autonomous County of Fuxin"
            },
            {
                "name": "Jinfeng Zhao",
                "org": "State Key Lab of Molecular Reaction Dynamics"
            },
            {
                "name": "Pengyu Li",
                "org": "Department of Physics"
            },
            {
                "name": "Peng Song",
                "org": "Liaoning Key Laboratory of Semiconductor Light Emitting and Photocatalytic Materials"
            },
            {
                "name": "Lixin Xia",
                "org": "Department of Chemistry"
            }
        ],
        "title": "The excited-state multiple proton transfer mechanism of the 7-hydroxyquinoline-(CH",
        "abstract": "In this paper, the excited-state proton transfer (ESPT) of 7-hydroxyquinoline (7HQ) in hydrogen-donating methanol (MeOH) was investigated theoretically. The change in the calculated primary bond lengths and the infrared spectra of the 7HQ-(CH",
        "keywords": [
            ""
        ],
        "venue": "New Journal of Chemistry",
        "year": 2015,
        "id": "1HgJvqGA"
    },
    "xOfeosRU": {
        "authors": [
            {
                "name": "Hui Zhang",
                "org": ""
            },
            {
                "name": "Yan Shang",
                "org": ""
            },
            {
                "name": "Mingxia Li",
                "org": ""
            },
            {
                "name": "Hong Zhao",
                "org": ""
            },
            {
                "name": "Xuan Wang",
                "org": ""
            },
            {
                "name": "Baozhong Han",
                "org": ""
            }
        ],
        "title": "Theoretical study on the radical reaction mechanism in the cross-linking process of polyethylene",
        "abstract": "Theoretical investigation on the radical-initiated reactions of the polyethylene cross-linking process with the voltage stabilizer grafting is accomplished by density functional theory (DFT) calculations. At the B3LYP/6-311+G(d,p) level, the molecular properties of 22 reactions and reaction potential energy information of 18 radical-initiated reactions are obtained. The HOMO-LUMO energy gaps, ionization potentials, and electron affinities of the cross-linking agent, voltage stabilizer, antioxidant, and by-product in the polyethylene insulation composite are calculated. The results show that the by-product, cross-linking agent, and voltage stabilizer can effectively increase the electrical breakdown strength. In addition, aromatic ketone voltage stabilizer and hindered phenol antioxidants of the studied molecule can be grafted to polyethylene chain easily during the polyethylene cross-linking process, and they have excellent compatibility with polymers matrix. The investigation is expected to provide reliable information for optimizing process and for the development of the insulation material of high-voltage cable exceed 500 kV in real applications.",
        "keywords": [
            ""
        ],
        "venue": "RSC Advances",
        "year": 2015,
        "id": "xOfeosRU"
    },
    "XibiXbWL": {
        "authors": [
            {
                "name": "Yanling Cui",
                "org": "College of Physics and Chemistry, Liaoning University"
            },
            {
                "name": "Hong Zhao",
                "org": "Measurement and Testing Institute of Mongolian Autonomous County of Fuxin"
            },
            {
                "name": "Lai Jiang",
                "org": "Department of Geology, Liaoning Technical University"
            },
            {
                "name": "Pengyu Li",
                "org": "College of Physics and Chemistry, Liaoning University"
            },
            {
                "name": "Yong Ding",
                "org": "Liaoning Key Laboratory of Semiconductor Light Emitting and Photocatalytic Materials, Liaoning University"
            },
            {
                "name": "Peng Song",
                "org": "Liaoning Key Laboratory of Semiconductor Light Emitting and Photocatalytic Materials, Liaoning University"
            },
            {
                "name": "Lixin Xia",
                "org": "College of Physics and Chemistry, Liaoning University"
            }
        ],
        "title": "Solvation effect on the excited-state intramolecular proton transfer mechanism of 1-morpholinylmethyl-2-naphthol",
        "abstract": "In the present work, the solvent dependent excited-state intramolecular proton transfer (ESIPT) dynamics of 1-morpholinylmethyl-2-naphthol (MN) in n-hexane and acetonitrile have been investigated, based on the time-dependent density functional theory, as well as IEFPCM model. The theoretical results obtained, including the primary bond lengths, bond angles, and IR vibrational spectra, predict the possibility of ESIPT in the S",
        "keywords": [
            "Electronic spectra",
            "ESIPT",
            "Frontier molecular orbitals",
            "Potential energy curves"
        ],
        "venue": "Computational and Theoretical Chemistry",
        "year": 2015,
        "id": "XibiXbWL"
    },
    "inGsN4Oj": {
        "authors": [
            {
                "name": "Hui Zhang",
                "org": "Key Laboratory of Engineering Dielectrics and Its Application of Ministry of Education, College of Chemical and Environmental Engineering, Harbin University of Science and Technology"
            },
            {
                "name": "Yan Shang",
                "org": "Key Laboratory of Engineering Dielectrics and Its Application of Ministry of Education, College of Chemical and Environmental Engineering, Harbin University of Science and Technology"
            },
            {
                "name": "Hong Zhao",
                "org": "Key Laboratory of Engineering Dielectrics and Its Application of Ministry of Education, College of Chemical and Environmental Engineering, Harbin University of Science and Technology"
            },
            {
                "name": "Baozhong Han",
                "org": "Key Laboratory of Engineering Dielectrics and Its Application of Ministry of Education, College of Chemical and Environmental Engineering, Harbin University of Science and Technology"
            },
            {
                "name": "Zesheng Li",
                "org": "Key Laboratory of Cluster Science of Ministry of Education and School of Chemistry, Beijing Institute of Technology"
            }
        ],
        "title": "Study of the effect of valence bond isomerizations on electrical breakdown by adding acetophenone to polyethylene as voltage stabilizers",
        "abstract": "A theoretical investigation on the mechanisms of acetophenone added to polyethylene as voltage stabilizers is accomplished at the atomic and molecular levels. The five reaction pathways of valence bond isomerization of acetophenone have been elucidated. The electronic structures at the ground states and lowest triplet states of acetophenone and its valence bond isomers were calculated at the B3LYP/6-311+G(d,p) level. The HOMO-LUMO energy gaps, ionization potentials, and electron affinities at the ground states of studied molecules were obtained at the same level. The theoretical results are in good agreement with the available experimental findings. Our calculations indicate that the valence bond isomerization forming the H\u00fcckel structure is the major pathway, and the other valence bond isomerizations that yield Dewar, Ladenburg, and Bicyclopropylene acetophenones are minor pathways. Based on these results, several interesting voltage stabilizers have been designed.",
        "keywords": [
            "Acetophenone",
            "Electrical breakdown strength",
            "Polyethylene",
            "Transition state",
            "Valence bond isomerization"
        ],
        "venue": "Computational and Theoretical Chemistry",
        "year": 2015,
        "id": "inGsN4Oj"
    },
    "Nr1pU1d3": {
        "id": "Nr1pU1d3",
        "title": "The protective effects of traditional chinese medicine prescription, Han-Dan-Gan-Le, on CCl4-induced liver fibrosis in rats",
        "abstract": "Chinese medicine preparation composed of Salvia millorrhiza, Radix paeoniae, Astragalus membranaceus, Stephania tetrandra, and dried leaves of Ginkgo biloba. has been used successfully to treat human liver fibrosis and cirrhosis for years. This study was designed to examine the mechanisms of the protection. Male Wistar rats were given CC14 (1.2 ml/kg, 2 times/ week), 20% fat diet, and 30% alcohol in drinking water (every other day) for 6 weeks. Han-Dan-GanLe (0.5 and 1.0 g/kg, p.o., daily for 6 weeks) was administered to rats simultaneously to examine the protective effects against CCl4-induced liver fibrosis. The experimentally-induced liver fibrosis and other morphological alterations were significantly ameliorated by Han-Dan-Gan-Le. Han-Dan-GanLe treatments decreased CCl4-induced hepatic collagen accumulation by more than 50%, and significantly increased urinary excretion of hydroxyproline. The CCl4-induced lipid peroxidation in liver and serum was ameliorated as a result of Han-Dan-Gan-Le treatment, possibly by restoring the activity of Superoxide dismutase activity in liver and erythrocytes, In conclusion, Han-Dan-Gan-Le is effective in protecting against liver fibrosis. The mechanisms of the protection appear to be due to its antioxidant properties and the modulation of hepatic collagen metabolism. \u00a9 1998 Institute for Advanced Research in Asian Science and Medicine.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "ChengXiu Li",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "Ling Li",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "Jung Lou",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "W. X. Yang",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "Ting W. Lei",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "Yan H. Li",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "Jie Liu",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "MinLiang Cheng",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            },
            {
                "name": "Len H. Huang",
                "org": "Guiyang Medical College(Guiyang Medical College),Guiyang,China"
            }
        ],
        "venue": "American Journal of Chinese Medicine",
        "year": 1998
    },
    "AcDswsjJ": {
        "id": "AcDswsjJ",
        "title": "TOXICOLOGICAL HIGHLIGHT Purine Nucleoside Phosphorylase: A Fortuitous Cytosolic Arsenate Reductase?",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "michael p waalkes",
                "org": ""
            },
            {
                "name": "jie liu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "yty4nWgm": {
        "id": "yty4nWgm",
        "title": "Activation of PPAR-\u03b1 in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity",
        "abstract": "",
        "keywords": [
            "real time polymerase chain reaction",
            "cell cycle regulation",
            "stress response",
            "dna damage",
            "heat shock protein",
            "microarray data",
            "adaptive response",
            "wild type",
            "dna synthesis"
        ],
        "authors": [
            {
                "name": "kartik shankar",
                "org": ""
            },
            {
                "name": "vishal s vaidya",
                "org": ""
            },
            {
                "name": "j christopher corton",
                "org": ""
            },
            {
                "name": "thomas j bucci",
                "org": ""
            },
            {
                "name": "jie liu",
                "org": ""
            },
            {
                "name": "michael p waalkes",
                "org": ""
            },
            {
                "name": "harihara m mehendale",
                "org": ""
            }
        ],
        "venue": "The FASEB Journal",
        "year": 2003
    },
    "h1SzxsOF": {
        "id": "h1SzxsOF",
        "title": "The collagenolytic effects of the traditional Chinese medicine preparation, Han-Dan-Gan-Le, contribute to reversal of chemical-induced liver fibrosis in rats.",
        "abstract": "Han-Dan-Gan-Le (HDGL), a Chinese herb preparation composed of Stephaniat tetrandra, Salvia miltorrhiza, Radix paeoniae, Astragalus membranaceus, and Ginkgo biloba, has been used to treat human liver fibrosis. This study was designed to examine the therapeutic effect of HDGL on chemical-induced liver fibrosis in adult Wistar rats. Liver fibrosis was produced in rats by carbon tetrachloride (1.2 ml CCl(4)/kg, 2 times/week, after an initial dose of 5.0 ml CCl(4)/kg, sc), plus a diet of 20% fat, 0.05% cholesterol (continuous) and 30% alcohol in the drinking water ad libitum (every other day) for 8 weeks. HDGL (0.5 and 1.0 g/kg, ig, daily for 6 weeks) was administered to rats 72 hrs after the last dose of CCl(4) to examine its therapeutic effects on chemical-induced liver fibrosis. Upon pathological examination, the HDGL treatment had significantly reversed chemical-induced liver fibrosis and other hepatic lesions. Hepatic collagen accumulation induced by CCl(4) was markedly reduced by HDGL treatment, as evidenced by hepatic collagen content and by immunohistochemical analysis of type-I collagen in liver. HDGL appeared to stimulate the collagenolytic process in the liver, as a 30-50% increase in urinary excretion of hydroxyproline was observed with HDGL treatment as compared to rats only given CCl(4). In conclusion, HDGL can effectively reverse chemically induced liver fibrosis, and this appears to be due, at least in part, to the stimulation of hepatic collagenolysis, resulting in a resolution of hepatic fibrosis.",
        "keywords": [
            "collagen-i",
            "han-dan-gan-le (hdgl)",
            "liver fibrosis",
            "collagenolysis",
            "carbon tetrachloride",
            "traditional chinese medicine"
        ],
        "authors": [
            {
                "name": "Chengxiu Li",
                "org": "Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, USA"
            },
            {
                "name": "Jun Luo",
                "org": "Department of Pharmacology, Guiyang Medical College, China"
            },
            {
                "name": "Ling Li",
                "org": "Department of Pharmacology, Guiyang Medical College, China"
            },
            {
                "name": "Mingliang Cheng",
                "org": "Department of Pharmacology, Guiyang Medical College, China"
            },
            {
                "name": "Nenghui Huang",
                "org": "Department of Pharmacology, Guiyang Medical College, China"
            },
            {
                "name": "Jie Liu",
                "org": "Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, USA"
            },
            {
                "name": "Michael P Waalkes",
                "org": "Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, NC, USA"
            }
        ],
        "venue": "Life sciences",
        "year": 2003
    },
    "f9gM1l7w": {
        "authors": [
            {
                "name": "Xiao-Peng Li",
                "org": ""
            },
            {
                "name": "De-Hua Sun",
                "org": ""
            },
            {
                "name": "Bing Yue",
                "org": ""
            },
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Bang-Chun Wen",
                "org": ""
            }
        ],
        "title": "Bifurcation characteristics and control of a mass-spring-belt friction self-excited vibration system",
        "keywords": [
            "Bifurcation control",
            "Friction model",
            "Self-excited vibration",
            "Washout filter"
        ],
        "venue": "Zhendong yu Chongji/Journal of Vibration and Shock",
        "year": 2015,
        "id": "f9gM1l7w"
    },
    "kU08mJgi": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Wan-Sheng Zhao",
                "org": ""
            },
            {
                "name": "Xiao-Ming Kang",
                "org": ""
            },
            {
                "name": "Lin Gu",
                "org": ""
            },
            {
                "name": "Hong-Yu Wei",
                "org": ""
            }
        ],
        "title": "Orthogonal-testing experimental on micro-ultrasonic-machining of microcrystalline-mica-ceramic",
        "keywords": [
            "Micro-ultrasonic-machining (micro-USM)",
            "Microcrystalline-mica-ceramic (MCMC)",
            "Orthogonal-testing"
        ],
        "venue": "Shanghai Jiaotong Daxue Xuebao/Journal of Shanghai Jiaotong University",
        "year": 2010,
        "id": "kU08mJgi"
    },
    "lRp9oBAO": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Tian Li",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Machining of composite surface based on z-buffer method with torus tools",
        "keywords": [
            "Composite surface",
            "Computer graphics Interference checking",
            "Depth buffer",
            "Tool path generation method"
        ],
        "venue": "Jixie Gongcheng Xuebao/Journal of Mechanical Engineering",
        "year": 2010,
        "id": "lRp9oBAO"
    },
    "4NpAh5dO": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Yang Liu",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Xiao-Guang Wang",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "A centroid-based method of planar mechanism path indirect synthesis",
        "keywords": [
            "Fuzzy recognition",
            "Image matching",
            "Indirect synthesis",
            "Mechanism synthesis",
            "Path atlas"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2009,
        "id": "4NpAh5dO"
    },
    "HTVPpUyC": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Bin Li",
                "org": "Traffic and Mechanical Engineering School"
            },
            {
                "name": "DongLiang Lei",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "The locating ways of laying pipe manipulator",
        "keywords": [
            "Control theory",
            "Hydraulic system",
            "Laying pipe manipulator",
            "Locating system",
            "Locating way",
            "Mathematical model",
            "Module of collecting and transferring data",
            "Module of conversion interface",
            "Photoelectric target",
            "Wireless communicating module"
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2010,
        "id": "HTVPpUyC"
    },
    "CbOfLqYn": {
        "authors": [
            {
                "name": "Jiangzhen Guo",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            },
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            },
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            }
        ],
        "title": "Stiffness characteristics distribution of 3PRS/UPS parallel manipulator with actuation redundancy",
        "keywords": [
            "Evaluation index",
            "Parallel manipulator with actuation redundancy",
            "Screw theory",
            "Stiffness characteristics"
        ],
        "venue": "Beijing Hangkong Hangtian Daxue Xuebao/Journal of Beijing University of Aeronautics and Astronautics",
        "year": 2014,
        "id": "CbOfLqYn"
    },
    "zHcCeR3H": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation Beihang University"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation Beihang University"
            },
            {
                "name": "Tian Li",
                "org": "School of Mechanical Engineering and Automation Beihang University"
            },
            {
                "name": "Rufeng Xu",
                "org": "School of Mechanical Engineering and Automation Beihang University"
            }
        ],
        "title": "Five-axis flank milling of sculptured surface with barrel cutters",
        "keywords": [
            "Barrel cutter",
            "Flank milling",
            "Iterference avoidance",
            "Sculptured surface"
        ],
        "venue": "Key Engineering Materials",
        "year": 2009,
        "id": "zHcCeR3H"
    },
    "JxiL8RFD": {
        "authors": [
            {
                "name": "Tian Li",
                "org": ""
            },
            {
                "name": "Wuyi Chen",
                "org": ""
            },
            {
                "name": "Rufeng Xu",
                "org": ""
            },
            {
                "name": "Dan Wang",
                "org": ""
            }
        ],
        "title": "Flank milling for blisk with a barrel ball milling cutter",
        "keywords": [
            "Barrel ball milling cutter",
            "Blisk",
            "Five-aixs machining",
            "Flank milling"
        ],
        "venue": "Key Engineering Materials",
        "year": 2009,
        "id": "JxiL8RFD"
    },
    "gvPj3QZJ": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Xiao-Guang Wang",
                "org": ""
            },
            {
                "name": "Ming Li",
                "org": ""
            }
        ],
        "title": "Temperature control system of gene-type gain amplifier",
        "keywords": [
            "C51 program design",
            "Chip microprocessor",
            "Fuzzy control",
            "Fuzzy PID control",
            "PID control",
            "Simulation"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2008,
        "id": "gvPj3QZJ"
    },
    "y6uHLOZL": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Li-Na Jia",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Xiao-Guang Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Ming Li",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Development of a prototypical tester with gene chips to simulate robot's motion and analysis of its reliability",
        "keywords": [
            "Gene chip",
            "Hybridization",
            "Polymerase chain reaction amplification",
            "Reliability",
            "Robot",
            "Simulation"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2008,
        "id": "y6uHLOZL"
    },
    "SI5RFxFJ": {
        "authors": [
            {
                "name": "Jiang Zhen Guo",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wu Yi Chen",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Yong Sheng Sun",
                "org": ""
            }
        ],
        "title": "Development of multidimensional loading material testing machine",
        "keywords": [
            "Dynamics",
            "Experimental study",
            "Kane method",
            "Multidimensional loading material testing machine",
            "Parallel robot"
        ],
        "venue": "Materials Science Forum",
        "year": 2014,
        "id": "SI5RFxFJ"
    },
    "crn8ZYg2": {
        "authors": [
            {
                "name": "Wei-Gang Song",
                "org": ""
            },
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Bo Zuo",
                "org": ""
            }
        ],
        "title": "Semi-analytical solution to dynamic continuous model of belt conveyor with single drive",
        "keywords": [
            "Belt conveyor",
            "Dynamic continuous model",
            "Dynamics simulation",
            "Semi-analytical solution"
        ],
        "venue": "Meitan Xuebao/Journal of the China Coal Society",
        "year": 2012,
        "id": "crn8ZYg2"
    },
    "NDLdluLP": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Rui Fan",
                "org": ""
            },
            {
                "name": "Jiang Zhen Guo",
                "org": ""
            },
            {
                "name": "Wu Yi Chen",
                "org": ""
            },
            {
                "name": "Yong Sheng Sun",
                "org": ""
            }
        ],
        "title": "Design and experimental study of a 6-DOF material testing machine",
        "keywords": [
            "Compliant axis",
            "Material test",
            "Multiaxial material testing machine",
            "Parallel robot"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2013,
        "id": "NDLdluLP"
    },
    "YaFCWqWa": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wen-Zhu Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Zhi-Li Sun",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Liang Zhou",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Analyzing the factors affecting ball screw pair contact deformation",
        "keywords": [
            "Ball screw pair",
            "Contact angle",
            "Contact deformation",
            "Finite element model",
            "Helix angle"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2011,
        "id": "YaFCWqWa"
    },
    "WXHLJigW": {
        "authors": [
            {
                "name": "Shuo Chen",
                "org": "School of Mechanical Eng."
            },
            {
                "name": "Zhi Shang",
                "org": "School of Mechanical Eng."
            },
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Eng."
            },
            {
                "name": "Jun Zhao",
                "org": "Assembly Technology Development Grouplntel Corporation"
            },
            {
                "name": "Xi-Jun Fan",
                "org": "Cooperative Research Centre for Polymers"
            }
        ],
        "title": "Simulating the breakup and collision of drops in simple shear flow",
        "keywords": [
            "Breakup",
            "Collision",
            "Dissipative particle dynamics (DPD)",
            "Droplets"
        ],
        "venue": "Kung Cheng Je Wu Li Hsueh Pao/Journal of Engineering Thermophysics",
        "year": 2007,
        "id": "WXHLJigW"
    },
    "nSZTWYa6": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Jiang Zhen Guo",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wu Yi Chen",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Design and experimental study of a 3-DOF parallel swivel head",
        "keywords": [
            "Hybrid machine tool",
            "Kinematic redundancy",
            "Parallel robot",
            "Singularity-free workspace"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2013,
        "id": "nSZTWYa6"
    },
    "2vQerCvh": {
        "authors": [
            {
                "name": "Yutao Yan",
                "org": ""
            },
            {
                "name": "Baomin Li",
                "org": ""
            },
            {
                "name": "Dan Wang",
                "org": ""
            }
        ],
        "title": "Tribological properties of HIP-Si3N4 ceramic/45 steel under dry friction and water lubrication",
        "keywords": [
            "Adhesive wear",
            "Chemical fretting wear",
            "Dry friction",
            "HITH117 P-Si3N4 ceramic",
            "Water lubrication"
        ],
        "venue": "Run Hua Yu Mi Feng/Lubrication Engineering",
        "year": 2005,
        "id": "2vQerCvh"
    },
    "A6GE5GpZ": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Bin Li",
                "org": "Traffic and Mechanical Engineering School"
            }
        ],
        "title": "Study of locating ways of pipelaying manipulator",
        "keywords": [
            "Laying pipe",
            "Manipulator",
            "Photoelectric locating system",
            "Photoelectric target"
        ],
        "venue": "Proceedings - International Conference on Electrical and Control Engineering, ICECE 2010",
        "year": 2010,
        "id": "A6GE5GpZ"
    },
    "Kopic5vr": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Stiffness analysis of a hexaglide parallel loading mechanism",
        "keywords": [
            "Eigenscrew decomposition",
            "Parallel loading mechanism",
            "Stiffness",
            "Workspace"
        ],
        "venue": "Mechanism and Machine Theory",
        "year": 2013,
        "id": "Kopic5vr"
    },
    "1tqRyQoI": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Eng."
            },
            {
                "name": "Shuo Chen",
                "org": "School of Mechanical Eng."
            },
            {
                "name": "Zhi Shang",
                "org": "School of Mechanical Eng."
            },
            {
                "name": "Jie Yi",
                "org": "Mechanical Design Dept. Server R and D Division"
            },
            {
                "name": "Xi-Jun Fan",
                "org": "Cooperative Research Centre for Polymers"
            }
        ],
        "title": "The simulation of fluid flow through a square channel with parallel implementation of dissipative particle dynamics",
        "keywords": [
            "Dissipative particle dynamics (DPD)",
            "Parallel computation",
            "Square channel"
        ],
        "venue": "Shanghai Jiaotong Daxue Xuebao/Journal of Shanghai Jiaotong University",
        "year": 2007,
        "id": "1tqRyQoI"
    },
    "SjUtPR1p": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Liang Zhou",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Zhi-Li Sun",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Jin-Cheng Du",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Motion reliability analysis of ball screw pair based on Monte Carlo method",
        "keywords": [
            "Ball screw pair",
            "MATLAB",
            "Monte Carlo method",
            "Motion reliability",
            "Random sample"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2012,
        "id": "SjUtPR1p"
    },
    "1EO7bwFN": {
        "authors": [
            {
                "name": "Zhe Yuan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Zhi-Li Sun",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Cong-Hui Chen",
                "org": "Shenyang Aero Engine Research Institute"
            }
        ],
        "title": "GA-based optimum profile modification of spur gears for vibration damping",
        "keywords": [
            "Gear",
            "Genetic algorithm",
            "Profile modification",
            "Transmission error",
            "Vibration"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2010,
        "id": "1EO7bwFN"
    },
    "KJFI86Tm": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Qiang Liu",
                "org": ""
            },
            {
                "name": "Song Mei Yuan",
                "org": ""
            }
        ],
        "title": "Research of a general method for the data migration in cutting parameters database of industry-oriented applications",
        "keywords": [
            "Combination",
            "Cutting parameters database",
            "Industry-oriented",
            "Metabase",
            "Separation"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2013,
        "id": "KJFI86Tm"
    },
    "wNXCR7eH": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Simulation research on adaptive control of a six-degree-of-freedom material-testing machine",
        "keywords": [
            "6-DOF material-testing Machine",
            "Adaptive control",
            "Parallel robot",
            "Stiffness estimation"
        ],
        "venue": "International Journal of Advanced Robotic Systems",
        "year": 2014,
        "id": "wNXCR7eH"
    },
    "tNSwZT2q": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Zhitong Chen",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Detection and control of non-linear errors in 5-axis machining",
        "keywords": [
            "Error detection",
            "Interpolation",
            "Machine tools",
            "Machining"
        ],
        "venue": "Beijing Hangkong Hangtian Daxue Xuebao/Journal of Beijing University of Aeronautics and Astronautics",
        "year": 2008,
        "id": "tNSwZT2q"
    },
    "zLIv4I9E": {
        "authors": [
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            },
            {
                "name": "Huan Liu",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            },
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics"
            }
        ],
        "title": "Statics and stiffness of 3DOF parallel loading mechanism",
        "keywords": [
            "Elastic deformation",
            "Parallel mechanism",
            "Static stiffness",
            "Statics",
            "Stiffness characteristic"
        ],
        "venue": "Beijing Hangkong Hangtian Daxue Xuebao/Journal of Beijing University of Aeronautics and Astronautics",
        "year": 2014,
        "id": "zLIv4I9E"
    },
    "sICkZLf3": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Rui Fan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Wuyi Chen",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Performance enhancement of a three-degree-of-freedom parallel tool head via actuation redundancy",
        "keywords": [
            "Actuation redundancy",
            "Dexterity",
            "Hybrid machine tool",
            "Parallel manipulator",
            "Stiffness"
        ],
        "venue": "Mechanism and Machine Theory",
        "year": 2014,
        "id": "sICkZLf3"
    },
    "5AuMWFZd": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Hui Guo",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Zhi-Li Sun",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Normal and inverse pose solutions to 3-RPS parallel robot based on ADAMS",
        "keywords": [
            "ADAMS software",
            "Inverse solution",
            "Kinematic analysis",
            "Normal solution",
            "Parallel robot",
            "Simulation"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2005,
        "id": "5AuMWFZd"
    },
    "me4UKkFb": {
        "authors": [
            {
                "name": "Dan Wang",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Rui-Cheng Lu",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Yu-Tao Yan",
                "org": "School of Mechanical Engineering and Automation"
            },
            {
                "name": "Zhi-Li Sun",
                "org": "School of Mechanical Engineering and Automation"
            }
        ],
        "title": "Modification research and contact analysis of aero-engine gears",
        "keywords": [
            "Contact analysis",
            "Finite element",
            "Gear profile modification",
            "Involute tooth profile",
            "Thermo-elastic coupled analysis"
        ],
        "venue": "Dongbei Daxue Xuebao/Journal of Northeastern University",
        "year": 2013,
        "id": "me4UKkFb"
    },
    "3WprcXXQ": {
        "authors": [
            {
                "name": "J. Si",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "S. Huang",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "H. Shi",
                "org": "Shandong Provincial Medical Imaging Research Institute"
            },
            {
                "name": "Z. Liu",
                "org": "Department of Head and Neck Oncology"
            },
            {
                "name": "Q. Hu",
                "org": "Shandong Provincial Medical Imaging Research Institute"
            },
            {
                "name": "G. Wang",
                "org": "Shandong Provincial Medical Imaging Research Institute"
            },
            {
                "name": "G. Shen",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "D. Zhang",
                "org": "Department of Oral and Maxillofacial Surgery"
            }
        ],
        "title": "Usefulness of 3T diffusion-weighted MRI for discrimination of reactive and metastatic cervical lymph nodes in patients with oral squamous cell carcinoma: A pilot study",
        "keywords": [
            "Apparent diffusion coefficient",
            "Cervical lymph node metastasis",
            "Diffusion-weighted magnetic resonance imaging",
            "Oral squamous cell carcinoma"
        ],
        "venue": "Dentomaxillofacial Radiology",
        "year": 2014,
        "id": "3WprcXXQ"
    },
    "xXxsR9ex": {
        "authors": [
            {
                "name": "Shuang Miao",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Linlin Xing",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Jingjing Qi",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Hui Yu",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Pan Jiang",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Bingqing Sun",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Junsheng Cui",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Changcan Ou",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Qinghai Hu",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            }
        ],
        "title": "Roles of the TonB1 and TonB2 proteins in haemin iron acquisition and virulence in Riemerella anatipestifer",
        "abstract": "Two TonB systems in Riemerella anatipestifer were found and characterized as ExbB1\u2013ExbD1\u2013TonB1 and ExbB2\u2013ExbD2\u2013ExbD2\u2032\u2013TonB2, but the significance of two sets of TonB complexes in R. anatipestifer is not clear. In this study, by deleting the tonB1 or tonB2 gene of R. anatipestifer strain CH3, we investigated the roles of the TonB1 and TonB2 proteins in iron acquisition and virulence. The results showed that strain CH3 could utilize haemin as the sole iron source in the presence of L-cysteine, but haemin iron acquisition was defective in the CH3\u0394tonB1 mutant, and the deletion of either tonB1 or tonB2 significantly reduced adhesion to and invasion of Vero cells. Animal experiments indicated that the LD<inf>50</inf> of the CH3\u0394tonB1 and CH3\u0394tonB2mutants in ducklings was \u223c224- and \u223c87-fold, respectively, higher than that of the WT CH3 strain. Additional analysis indicated that blood bacterial loading of ducklings infected with CH3\u0394tonB1 or CH3\u0394tonB2 decreased significantly compared with that found for WT CH3-infected ducklings. Thus, our results indicated that the TonB1, but not TonB2 protein, is involved in haemin iron acquisition and that both TonB proteins are necessary for optimal bacterial virulence.",
        "keywords": [
            ""
        ],
        "venue": "Microbiology (United Kingdom)",
        "year": 2015,
        "id": "xXxsR9ex"
    },
    "N7hoOQPC": {
        "authors": [
            {
                "name": "Fengying Lu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Shuang Miao",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Jing Tu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Xintao Ni",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Linlin Xing",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Hui Yu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Ling Pan",
                "org": "Anhui Agricultural University"
            },
            {
                "name": "Qinghai Hu",
                "org": "Shanghai Veterinary Research Institute"
            }
        ],
        "title": "The role of TonB-dependent receptor TbdR1 in Riemerella anatipestifer in iron acquisition and virulence",
        "abstract": "Riemerella anatipestifer is an important duck pathogen and causes serious economic losses to the duck industry worldwide. To date, four full R. anatipestifer genomic sequences have been submitted to the GenBank database and 31 TonB-dependent outer membrane receptors, which may play critical roles in host-bacteria interactions, were predicted for R. anatipestifer strain GSM15868. In our previous study, we reported that the TonB-dependent receptor TbdR1 was a cross immunogenic antigen among R. anatipestifer serotypes 1, 2, and 10. However, the biological functions of TbdR1 in R. anatipestifer remain unclear. In the present study, a tbdR1 (Riean_1607) deletion mutant CH3\u03b4. tbdR1 of R. anatipestifer strain CH3 was constructed and characterized for iron-limited growth, biofilm formation, and pathogenicity to ducklings. Our results showed that TbdR1 was involved in hemin iron acquisition and the tbdR1 deletion significantly reduced biofilm formation and adhesion to and invasion of Vero cells. Animal experiments indicated that the median lethal dose of the CH3\u03b4. tbdR1 mutant in ducklings was about 45-fold higher than that of the wild-type CH3 strain. Additional analysis indicated that bacterial loads in blood, liver, and brain tissues in CH3\u03b4. tbdR1-infected ducklings were decreased significantly compared to those in wild-type CH3-infected ducklings. Thus, our results demonstrated that TbdR1 was involved in hemin iron acquisition and necessary for optimal bacterial virulence. \u00a9 2013 Elsevier B.V.",
        "keywords": [
            "Deletion mutant",
            "Iron acquisition",
            "Riemerella anatipestifer",
            "TonB-dependent receptor",
            "Virulence"
        ],
        "venue": "Veterinary Microbiology",
        "year": 2013,
        "id": "N7hoOQPC"
    },
    "cGynjIqb": {
        "authors": [
            {
                "name": "Linlin Xing",
                "org": "College of Animal Science and Veterinary Medicine, Shandong Agricultural University"
            },
            {
                "name": "Hui Yu",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Jingjing Qi",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Pan Jiang",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Bingqing Sun",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Junsheng Cui",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Changcan Ou",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Weishan Chang",
                "org": "College of Animal Science and Veterinary Medicine, Shandong Agricultural University"
            },
            {
                "name": "Qinghai Hu",
                "org": "Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences"
            }
        ],
        "title": "ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer",
        "abstract": "To investigate the genetic basis of erythromycin resistance in Riemerella anatipestifer, the MIC to erythromycin of 79 R. anatipestifer isolates from China and one typed strain, ATCC11845, were evaluated. The results showed that 43 of 80 (53.8%) of the tested R. anatipestifer strains showed resistance to erythromycin, and 30 of 43 erythromycin-resistant R. anatipestifer strains carried ermF or ermFU with an MIC in the range of 32-2048 \u03bcg/ml, while the other 13 strains carrying the ereD gene exhibited an MIC of 4-16 \u03bcg/ml. Of 30 ermF + R. anatipestifer strains, 27 (90.0%) carried the ermFU gene which may have been derived from the CTnDOT-like element, while three other strains carried ermF from transposon Tn4351. Moreover,sequence analysis revealed that ermF, ermFU, and ereD were located within the multiresistance region of the R. anatipestifer genome. Copyright:",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2015,
        "id": "cGynjIqb"
    },
    "6GNZWCfm": {
        "authors": [
            {
                "name": "Qinghai Hu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Shuang Miao",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Xintao Ni",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Fengying Lu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Hui Yu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Linlin Xing",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Pan Jiang",
                "org": "Shanghai Veterinary Research Institute"
            }
        ],
        "title": "Construction of a shuttle vector for use in Riemerella anatipestifer",
        "abstract": "Riemerella anatipestifer causes epizootic infectious disease in poultry and serious economic losses, especially to the duck industry. Four complete genome sequences of R. anatipestifer strains are now available. However, functional studies have been limited by the lack of an effective shuttle vector. In this study, we constructed a shuttle vector, pRES, which was able to transfer plasmid DNA between Escherichia coli and R. anatipestifer strains. The vector contains the putative replication origin from R. anatipestifer plasmid pRA7026 and a ColE1 ori for replication in R. anatipestifer and E. coli respectively. In addition, it contains oriT for transferring the vector into R. anatipestifer by conjugation, and the putative promoter of the streptothricin resistance gene of plasmid pRA0726 for heterologous gene expression in R. anatipestifer. The vector pRES will be useful in the investigation of gene function in R. anatipestifer. \u00a9 2013 Elsevier B.V.",
        "keywords": [
            "Complementation",
            "Conjugation",
            "Escherichia coli",
            "Riemerella anatipestifer",
            "Shuttle vector"
        ],
        "venue": "Journal of Microbiological Methods",
        "year": 2013,
        "id": "6GNZWCfm"
    },
    "ymh4s3i7": {
        "authors": [
            {
                "name": "Jing Tu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Fengying Lu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Shuang Miao",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Xintao Ni",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Pan Jiang",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Hui Yu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Linlin Xing",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Shengqing Yu",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Chan Ding",
                "org": "Shanghai Veterinary Research Institute"
            },
            {
                "name": "Qinghai Hu",
                "org": "Shanghai Veterinary Research Institute"
            }
        ],
        "title": "The siderophore-interacting protein is involved in iron acquisition and virulence of riemerella anatipestifer strain CH3",
        "abstract": "Riemerella anatipestifer causes epizootic infectious disease in poultry and serious economic losses especially to the duck industry. However, little is known regarding the molecular basis of its pathogenesis. The ability to acquire iron under low-iron conditions is related to the virulence of a variety of bacterial pathogens. In this study, a sip (Riean_1281) deletion mutant CH3\u03b4. sip was constructed and characterized for iron-limited growth, biofilm formation, and pathogenicity to ducklings. Results showed that siderophore-interacting protein (SIP) was involved in iron utilization and the sip deletion significantly reduced biofilm formation and adherence to and invasion of Vero cells. In addition, the sip gene was absent in 1 of 24 (4.17%) virulent strains and 2 of 3 (66.7%) avirulent strains of R. anatipestifer, and the sip gene from six R. anatipestifer strains, which belong to serotypes 1, 2, and 10, respectively, shared 100% amino acid identities to those of R. anatipestifer strains DSM15868 and RA-GD. These results suggested that siderophore-mediated iron acquisition may be an important iron-uptake pathway in R. anatipestifer. Animal experiments indicated that the median lethal dose of the CH3\u03b4. sip mutant in ducklings was about 35-fold higher than that of the wild-type CH3 strain. Thus, our results demonstrated that R. anatipestifer SIP was involved in iron acquisition and necessary for its optimal virulence. \u00a9 2013 Elsevier B.V.",
        "keywords": [
            "Deletion mutant",
            "Iron acquisition",
            "Riemerella anatipestifer",
            "Siderophore-interacting protein (SIP)",
            "Virulence"
        ],
        "venue": "Veterinary Microbiology",
        "year": 2014,
        "id": "ymh4s3i7"
    },
    "2UgNC7Bl": {
        "authors": [
            {
                "name": "Lan Wang",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Ya-Ping Wang",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Chun-Xue Xu",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Zi-Yi An",
                "org": "National Research Center for Geoanalysis"
            }
        ],
        "title": "Pollution characteristics and ecological risk assessment of heavy metals in the surface sediments of the Yangtze River",
        "abstract": "The concentrations of Cr, Co, Ni, Cu, Zn, Pb, Cd, As and Hg in surface sediment samples of Yangtze River collected in 2007 were analyzed and evaluated. The results indicated that the concentrations of Cu, Zn, Pb, Cd, As and Hg were significantly higher than those measured in 1990s.Principal Component Analysis showed that the cumulative proportion of the first three components accounted for 86.75% of the total variable, indicating the three major sources of heavy metals were industrial and mining wastewater, weathering and erosion of rocks, and urban electroplating industry wastewater and natural sources. Geoaccumulation index (I",
        "keywords": [
            "Ecological risk",
            "Heavy metal",
            "Pollution estimation",
            "Principal component analysis",
            "Sediment",
            "Yangtze River"
        ],
        "venue": "Huanjing Kexue/Environmental Science",
        "year": 2012,
        "id": "2UgNC7Bl"
    },
    "1cxH7M27": {
        "authors": [
            {
                "name": "Lan Wang",
                "org": ""
            },
            {
                "name": "Yaping Wang",
                "org": ""
            },
            {
                "name": "Wenzhao Zhang",
                "org": ""
            },
            {
                "name": "Chunxue Xu",
                "org": ""
            },
            {
                "name": "Ziyi An",
                "org": ""
            }
        ],
        "title": "Multivariate statistical techniques for evaluating and identifying the environmental significance of heavy metal contamination in sediments of the Yangtze River, China",
        "abstract": "The concentrations of heavy metals (Cr, Co, Ni, Cu, Zn, Pb, Cd, As, Hg, and Fe) in sediments of the Yangtze River, China, were investigated to evaluate levels of contamination and their potential sources. The lowest heavy metal concentrations were found in the source regions of the river basin. Relatively high concentrations of metals, except Cr, were found in the Sichuan Basin, and the highest concentrations were in the Xiangjiang and Shun'anhe rivers. All concentrations, except Ni, were higher than global averages. Principal component analysis and hierarchical cluster analysis showed that Zn, Pb, As, Hg, and Cd were derived mainly from the exploitation of various multi-metal minerals, industrial wastewater, and domestic sewage. Cu, Co, and Fe were derived mainly from natural weathering (erosion). Cr and Ni were derived mainly from agricultural activities, municipal and industrial wastewater. Sediment pollution was assessed using the geoaccumulation index (I ",
        "keywords": [
            "Heavy metals",
            "Multivariate statistical techniques",
            "Sediment contamination",
            "Yangtze River (Changjiang)"
        ],
        "venue": "Environmental Earth Sciences",
        "year": 2014,
        "id": "1cxH7M27"
    },
    "nPtk9sAl": {
        "authors": [
            {
                "name": "Lan Wang",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Yaping Wang",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Chunxue Xu",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Ziyi An",
                "org": "National Research Center for Geoanalysis"
            },
            {
                "name": "Suming Wang",
                "org": "National Research Center for Geoanalysis"
            }
        ],
        "title": "Analysis and evaluation of the source of heavy metals in water of the River Changjiang",
        "abstract": "In order to analyze and evaluate different trace metals on surface water of the Changjiang River, concentrations of dissolved trace metals (Cu, Ni, Fe, Co, Sc, Al, Zn, Pb, Cd, Se, As, Cr, and Hg), major elements(Ca and Mg), and nutrient(NO-{3} {-}) were measured. Samples were taken at 76 positions along Changjiang River in flood and dry seasons during 2007-2008. Spatial distributions identified two main large zones mainly influenced by mineral erosion (sites 1-22) and anthropogenic action (sites 23-76), respectively. Principal component analysis (PCA) and hierarchical cluster analysis were used to identify the variance distinguishing the origin of water. Four significant components were extracted by PCA, explaining 74.91% of total variable. Cu, Ni, Fe, Co, Sc, Al, Ca, and Mg were mainly associated with the weathering and erosion of various rocks and minerals, while an anthropogenic source was identified for Cd and As. Although erosion was one source of Pb and Zn, they were also input by atmospheric deposition and industrial pollutions. NO-{3} {-} and Se were mainly associated with agriculture activities. However, Hg and Cr showed different sources. CA confirmed and completed the results obtained by PCA, classifying the data into two large groups representing different areas. Group 1 referred to the upper reaches which represented samples mainly corresponding to natural background areas. Group 2 referred to the middle and lower reaches including samples under anthropogenic influence. Meanwhile, group 2 was subdivided into three new groups, representing agricultural, industrial, and various artificial pollution sources, respectively. \u00a9 2010 Springer Science+Business Media B.V.",
        "keywords": [
            "Changjiang River",
            "HCA",
            "Heavy metals",
            "PCA",
            "Water pollution"
        ],
        "venue": "Environmental Monitoring and Assessment",
        "year": 2011,
        "id": "nPtk9sAl"
    },
    "KBKdqKGH": {
        "id": "KBKdqKGH",
        "title": "Commutable whole blood reference materials for hemoglobin A1c validated on multiple clinical analyzers.",
        "abstract": "Background The measurement of hemoglobin A1c (HbA1c) is important for diagnosing diabetes mellitus as well as assessing glycemic control in diabetic patients. Commutable whole blood certified reference materials (CRMs) are needed in the measurement of HbA1c for method validation and/or as quality controls. Methods We developed three levels of hemolyzed whole blood CRMs for HbA1c. The certified values were determined using liquid chromatography-isotope dilution tandem mass spectrometry method (LC-IDMS/MS) where two \"signature\" hexapeptides of HbA1c and hemoglobin A0 (HbA0) were used as the calibration standards. The concentrations of the hexapeptide solutions were determined by amino acid analysis by the LC-IDMS/MS method using amino acid CRMs as the calibration standards. The commutability study was conducted by measuring 25 patient specimens and the whole blood CRMs by both LC-IDMS/MS method and various routine methods using six different clinical analyzers. Results The certified values were determined to be 35.1\u00b12.0, 50.3\u00b11.9 and 65.8\u00b12.6 mmol/mol, respectively. These CRMs showed good commutability on five of the six clinical analyzers but showed poor commutability on one of the clinical analyzers that used similar method as two other analyzers where good commutability was observed. Conclusions With certified target values based on metrological traceability and good commutability on most of the clinical analyzers, the developed whole blood CRMs can be used for method validation or as quality control materials in the measurement of HbA1c. The commutability study results also underscored the need of commutability testing of clinical CRMs using various clinical analyzers.",
        "keywords": [
            "certified reference material",
            "commutability",
            "diabetes",
            "hemoglobin A1c",
            "isotope dilution mass spectrometry"
        ],
        "authors": [
            {
                "name": "Hong Liu",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Science Authority, Singapore, Singapore."
            },
            {
                "name": "Lingkai Wong",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Science Authority, Singapore, Singapore."
            },
            {
                "name": "Sharon Yong",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Science Authority, Singapore, Singapore."
            },
            {
                "name": "Qinde Liu",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Science Authority, 1 Science Park Road, #01-05/06, The Capricorn, Singapore Science Park II, Singapore 117528, Singapore, Phone: +65 67751605 ext 102, Fax: +65 67751398."
            },
            {
                "name": "Tang Lin Teo",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Science Authority, Singapore, Singapore."
            },
            {
                "name": "Tong Kooi Lee",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Science Authority, Singapore, Singapore."
            },
            {
                "name": "Tze Ping Loh",
                "org": "Department of Laboratory Medicine, National University Hospital, Singapore, Singapore."
            },
            {
                "name": "Sunil Kumar Sethi",
                "org": "Department of Laboratory Medicine, National University Hospital, Singapore, Singapore."
            },
            {
                "name": "Moh Sim Wong",
                "org": "Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore."
            },
            {
                "name": "Shelia Marie Delos Santos Cosio",
                "org": "Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore."
            },
            {
                "name": "Clement K M Ho",
                "org": "Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore."
            },
            {
                "name": "Johnson Weng Sung Setoh",
                "org": "Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Singapore."
            },
            {
                "name": "Sok Fong Maria Lim",
                "org": "Laboratory Department, Mount Alvernia Hospital, Singapore, Singapore."
            },
            {
                "name": "Grace Lay Lay Lee",
                "org": "Laboratory - Headquarter, National Healthcare Group Diagnostics, Singapore, Singapore."
            },
            {
                "name": "Hafash Khalid",
                "org": "Laboratory - Woodlands Polyclinic, National Healthcare Group Diagnostics, Singapore, Singapore."
            },
            {
                "name": "Sharine Lim",
                "org": "Laboratory - Bukit Batok Polyclinic, National Healthcare Group Diagnostics, Singapore, Singapore."
            },
            {
                "name": "Choong-Weng Lam",
                "org": "Department of Laboratory Medicine, Ng Teng Fong General Hospital, Singapore, Singapore."
            },
            {
                "name": "Mee-Yin Lee",
                "org": "Department of Laboratory Medicine, Ng Teng Fong General Hospital, Singapore, Singapore."
            },
            {
                "name": "Chin Pin Yeo",
                "org": "Department of Clinical Pathology, Singapore General Hospital, Singapore, Singapore."
            },
            {
                "name": "Pallavi Ravikiran Chincholkar",
                "org": "Department of Clinical Pathology, Singapore General Hospital, Singapore, Singapore."
            },
            {
                "name": "Robert Hawkins",
                "org": "Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore, Singapore."
            },
            {
                "name": "Bih-Yann Ng",
                "org": "Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore, Singapore."
            }
        ],
        "venue": "Clinical chemistry and laboratory medicine",
        "year": 2018
    },
    "UAIR7YYH": {
        "id": "UAIR7YYH",
        "title": "Liquid chromatography\u2013isotope dilution tandem mass spectrometry method for the measurement of urea in human serum and assignment of reference values to external quality assessment samples",
        "abstract": "Abstract   Reference measurement procedures are essential for the accurate measurement of urea in human serum. The widely used gas chromatography-isotope dilution mass spectrometry (GC\u2013IDMS) involves tedious derivatization processes. We developed and validated a simple liquid chromatography-isotope dilution tandem mass spectrometry (LC-IDMS/MS) method for the measurement of urea in human serum.  In this method,  13 C, 15 N 2 -urea was spiked into serum samples as the internal standard, and pure urea certified reference material (CRM) was used as the calibration standard to ensure the traceability of the measurements to the International System of Units (SI). The sample cleanup procedure involved a simple protein precipitation step, followed by centrifugation and filtration. The developed LC-IDMS/MS method was found to be accurate and highly reproducible. The coefficient of variation (CV) was generally below 1%. Good accuracy was demonstrated by measuring serum CRMs from two National Metrology Institutes (NMIs) with relative deviations from the certified values being close to or below 1%, and measurement uncertainties of 2.0%\u20132.8%. The method was used to assign the reference values of serum urea in ten cycles of an external quality assessment (EQA) program for clinical laboratories over a period of four years. The robust mean of the reported results from clinical laboratories using automated analyzers were close to the assigned values from LC-IDMS/MS method.  With good accuracy and precision, as well as simple sample cleanup procedure, the developed LC-IDMS/MS method can be used as a reference measurement procedure for the measurement of urea in human serum.",
        "keywords": "",
        "authors": [
            {
                "name": "Sharon Yong",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Hong Liu",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Lingkai Wong",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Hui Ling Teo",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Yizhao Chen",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Qinde Liu",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Tang Lin Teo",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            },
            {
                "name": "Tong Kooi Lee",
                "org": "Chemical Metrology Division, Applied Sciences Group, Health Sciences Authority, Singapore"
            }
        ],
        "venue": "International Journal of Mass Spectrometry",
        "year": 2017
    },
    "b0EhuMhw": {
        "id": "b0EhuMhw",
        "title": "High polarity analytes in biological matrix: determination of urea and uric acid in human serum (CCQM-K109)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Qinde Liu",
                "org": ""
            },
            {
                "name": "Hong Liu",
                "org": ""
            },
            {
                "name": "Yizhao Chen",
                "org": ""
            },
            {
                "name": "Sharon Yong",
                "org": ""
            },
            {
                "name": "Hui Ling Teo",
                "org": ""
            },
            {
                "name": "Lingkai Wong",
                "org": ""
            },
            {
                "name": "Tang Lin Teo",
                "org": ""
            },
            {
                "name": "Veronica Vamathevan",
                "org": ""
            },
            {
                "name": "Eliane C P do Rego",
                "org": ""
            },
            {
                "name": "Wagner Wollinger",
                "org": ""
            },
            {
                "name": "Jane L N Fernandes",
                "org": ""
            },
            {
                "name": "Tania M Monteiro",
                "org": ""
            },
            {
                "name": "Bruno C Garrido",
                "org": ""
            },
            {
                "name": "Fernando M Violante",
                "org": ""
            },
            {
                "name": "Lian Hua Shi",
                "org": ""
            },
            {
                "name": "Hai Hong He",
                "org": ""
            },
            {
                "name": "Can Quan",
                "org": ""
            },
            {
                "name": "Bei Xu",
                "org": ""
            },
            {
                "name": "Hong Mei Li",
                "org": ""
            },
            {
                "name": "Xin Hua Dai",
                "org": ""
            },
            {
                "name": "Ya Juan He",
                "org": ""
            },
            {
                "name": "Man-fung Lo",
                "org": ""
            },
            {
                "name": "Yiu-chung Yip",
                "org": ""
            },
            {
                "name": "Julie Cabillic",
                "org": ""
            },
            {
                "name": "Vincent Delatour",
                "org": ""
            },
            {
                "name": "R\u00fcdiger Ohlendorf",
                "org": ""
            },
            {
                "name": "Andre Henrion",
                "org": ""
            },
            {
                "name": "Migaku Kawaguchi",
                "org": ""
            },
            {
                "name": "Dukjin Kang",
                "org": ""
            },
            {
                "name": "Hwashim Lee",
                "org": ""
            },
            {
                "name": "Mariana Arce Osuna",
                "org": ""
            },
            {
                "name": "Victor Serrano",
                "org": ""
            },
            {
                "name": "Claudia Marcela Salazar Arzate",
                "org": ""
            },
            {
                "name": "Anatoliy Krylov",
                "org": ""
            },
            {
                "name": "E Lopushanskaya",
                "org": ""
            },
            {
                "name": "Jintana Nammoonnoy",
                "org": ""
            },
            {
                "name": "Ahmet Ceyhan G\u00f6ren",
                "org": ""
            },
            {
                "name": "Simay G\u00fcnd\u00fcz",
                "org": ""
            },
            {
                "name": "Hasibe Yilmaz",
                "org": ""
            },
            {
                "name": "Christopher Mussell",
                "org": ""
            },
            {
                "name": "John Warren",
                "org": ""
            },
            {
                "name": "Jeanita S Pritchett",
                "org": ""
            },
            {
                "name": "Katrice Lippa",
                "org": ""
            },
            {
                "name": "Michael A Nelson",
                "org": ""
            },
            {
                "name": "Blaza Toman",
                "org": ""
            },
            {
                "name": "Lorna T Sniegoski",
                "org": ""
            },
            {
                "name": "David Duewer",
                "org": ""
            }
        ],
        "venue": "Metrologia",
        "year": 2019
    },
    "xW5DcZOr": {
        "id": "xW5DcZOr",
        "title": "Comparison of CRMs and value-assigned quality controls: urea and uric Acid in human serum or plasma (CCQM-K142)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Tang Lin Teo",
                "org": ""
            },
            {
                "name": "Qinde Liu",
                "org": ""
            },
            {
                "name": "Pui Sze Cheow",
                "org": ""
            },
            {
                "name": "David Duewer",
                "org": ""
            },
            {
                "name": "Katrice Lippa",
                "org": ""
            },
            {
                "name": "Blaza Toman",
                "org": ""
            },
            {
                "name": "Mariana Arce Osuna",
                "org": ""
            },
            {
                "name": "Victor Serrano",
                "org": ""
            },
            {
                "name": "Claudia Marcela Salazar Arzate",
                "org": ""
            },
            {
                "name": "Lingkai Wong",
                "org": ""
            },
            {
                "name": "Yizhao Chen",
                "org": ""
            },
            {
                "name": "Sharon Yong",
                "org": ""
            },
            {
                "name": "Hui Ling Teo",
                "org": ""
            },
            {
                "name": "Hong Liu",
                "org": ""
            },
            {
                "name": "Benny Tong",
                "org": ""
            },
            {
                "name": "Dukjin Kang",
                "org": ""
            },
            {
                "name": "Hwashim Lee",
                "org": ""
            },
            {
                "name": "Xin Hua Dai",
                "org": ""
            },
            {
                "name": "Can Quan",
                "org": ""
            },
            {
                "name": "Lian Hua Shi",
                "org": ""
            },
            {
                "name": "Hong Mei Li",
                "org": ""
            },
            {
                "name": "Jeanita S Pritchett",
                "org": ""
            }
        ],
        "venue": "Metrologia",
        "year": 2019
    },
    "1f2Ko3HM": {
        "id": "1f2Ko3HM",
        "title": "Achieving comparability with IFCC reference method for the measurement of hemoglobin A1c by use of an improved isotope-dilution mass spectrometry method",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hong liu",
                "org": ""
            },
            {
                "name": "lingkai wong",
                "org": ""
            },
            {
                "name": "sharon yong",
                "org": ""
            },
            {
                "name": "qinde liu",
                "org": ""
            },
            {
                "name": "tong kooi lee",
                "org": ""
            }
        ],
        "venue": "Analytical and Bioanalytical Chemistry",
        "year": 2015
    },
    "UMeTfa7h": {
        "id": "UMeTfa7h",
        "title": "Mass fraction assignment of Amino Acids in acidic aqueous solution (CCQM-K78.a)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Steven Westwood",
                "org": ""
            },
            {
                "name": "Ralf Josephs",
                "org": ""
            },
            {
                "name": "Tiphaine Choteau",
                "org": ""
            },
            {
                "name": "Adeline Daireaux",
                "org": ""
            },
            {
                "name": "Robert Wielgosz",
                "org": ""
            },
            {
                "name": "Jeremy Melanson",
                "org": ""
            },
            {
                "name": "Marie-Pier Thibeault",
                "org": ""
            },
            {
                "name": "Juris Meija",
                "org": ""
            },
            {
                "name": "Can Quan",
                "org": ""
            },
            {
                "name": "Hongmei Li",
                "org": ""
            },
            {
                "name": "Ting Huang",
                "org": ""
            },
            {
                "name": "Wei Zhang",
                "org": ""
            },
            {
                "name": "Dewei Song",
                "org": ""
            },
            {
                "name": "Gustavo Martos",
                "org": ""
            },
            {
                "name": "Vincent Delatour",
                "org": ""
            },
            {
                "name": "R\u00fcdiger Ohlendorf",
                "org": ""
            },
            {
                "name": "Andr\u00e9 Henrion",
                "org": ""
            },
            {
                "name": "Elias Kakoulides",
                "org": ""
            },
            {
                "name": "Panagiota Giannikopoulou",
                "org": ""
            },
            {
                "name": "Charalampos Alexopoulos",
                "org": ""
            },
            {
                "name": "Kelly Chan",
                "org": ""
            },
            {
                "name": "W H Lam",
                "org": ""
            },
            {
                "name": "W H Fung",
                "org": ""
            },
            {
                "name": "Taichi Yamazaki",
                "org": ""
            },
            {
                "name": "A Krylov",
                "org": ""
            },
            {
                "name": "E Lopushanskaya",
                "org": ""
            },
            {
                "name": "S Kharitonov",
                "org": ""
            },
            {
                "name": "M Belyakov",
                "org": ""
            },
            {
                "name": "O Sokolova",
                "org": ""
            },
            {
                "name": "Qinde Liu",
                "org": ""
            },
            {
                "name": "Hong Liu",
                "org": ""
            },
            {
                "name": "Sharon Yong",
                "org": ""
            },
            {
                "name": "D\u00e9ir\u00e9e Prevoo-Franzsen",
                "org": ""
            },
            {
                "name": "Maria Fernandes-Whaley",
                "org": ""
            },
            {
                "name": "Byungjoo Kim",
                "org": ""
            },
            {
                "name": "Ji-Seon Jeong",
                "org": ""
            },
            {
                "name": "Ha-Jeong Kwon",
                "org": ""
            },
            {
                "name": "Inchul Yang",
                "org": ""
            },
            {
                "name": "Jintana Nammoonnoy",
                "org": ""
            },
            {
                "name": "Ahmet Ceyhan G\u00f6ren",
                "org": ""
            },
            {
                "name": "Simay G\u00fcnd\u00fcz",
                "org": ""
            },
            {
                "name": "Ilker \u00dcn",
                "org": ""
            },
            {
                "name": "G\u00f6khan Bilsel",
                "org": ""
            },
            {
                "name": "Sabine Biesenbruch",
                "org": ""
            },
            {
                "name": "Mark Lowenthal",
                "org": ""
            }
        ],
        "venue": "Metrologia",
        "year": 2019
    },
    "c5j5KIQI": {
        "authors": [
            {
                "name": "W. Liu",
                "org": "Hunan Biological and Electromechanical Polytechnic College"
            },
            {
                "name": "G.H. Liu",
                "org": "College of Veterinary Medicine"
            },
            {
                "name": "F. Li",
                "org": "Hunan Biological and Electromechanical Polytechnic College"
            },
            {
                "name": "D.S. He",
                "org": "Hunan Biological and Electromechanical Polytechnic College"
            },
            {
                "name": "T. Wang",
                "org": "College of Veterinary Medicine"
            },
            {
                "name": "X.F. Sheng",
                "org": "College of Veterinary Medicine"
            },
            {
                "name": "D.L. Zeng",
                "org": "College of Veterinary Medicine"
            },
            {
                "name": "F.F. Yang",
                "org": "College of Veterinary Medicine"
            },
            {
                "name": "Y. Liu",
                "org": "College of Veterinary Medicine"
            }
        ],
        "title": "Sequence variability in three mitochondrial DNA regions of Spirometra erinaceieuropaei spargana of human and animal health significance",
        "abstract": "Sequence variability in three mitochondrial DNA (mtDNA) regions, namely cytochrome c oxidase subunit 3 (cox3), NADH dehydrogenase subunits 1 and 4 (nad1 and nad4) in Spirometra erinaceieuropaei spargana from different geographical regions in China was examined. A portion of each of the cox3 (pcox3), nad1 (pnad1) and nad4 genes (pnad4) were amplified separately from individual S. erinaceieuropaei spargana by polymerase chain reaction (PCR). Representative amplicons were subjected to sequencing in order to estimate sequence variability. The sequences of pcox3, pnad1 and pnad4 were 541, 607 and 847'bp in length, respectively. The A+T contents of the sequences were 68.39-68.76% (pcox3), 63.76-64.91% (pnad1) and 67.18-67.77% (pnad4), respectively, while the intra-specific sequence variations within each of the S. erinaceieuropaei spargana were 0-1.5% for pcox3, 0-2.8% for pnad1 and 0-2.7% for pnad4. Phylogenetic analysis using neighbour joining (NJ), maximum likelihood (ML) and maximum parsimony (MP) methods, indicated that all the spargana isolates in Hunan Province represented S. erinaceieuropaei. These findings demonstrated clearly the usefulness of the three mtDNA sequences for population genetics studies of S. erinaceieuropaei spargana of human and animal health significance. \u00a9 2011 Cambridge University Press.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Helminthology",
        "year": 2012,
        "id": "c5j5KIQI"
    },
    "OnazJo6f": {
        "id": "OnazJo6f",
        "title": "Optimization on Synthesis Process of Magnetic Polymer Microspheres With Surface Carboxyl Groups",
        "abstract": "Magnetic polymer microspheres with surface carboxyl groups were synthesized by using dispersion polymerization method.The influence of acrylic acid amount,benzoperoxide amount,volume ratio of absolute alcohol and distilled water,reaction temperature on the surface carboxyl number of magnetic polymer microspheres was investigated.The results show that when amount of Fe3O4-KH-570 is 0.5 g,amount of acrylic acid is 1.0 g,amount of benzoperoxide is 2.0 g,the volume ratio of absolute alcohol and distilled water is 55\u223645,the reaction temperature is 75 \u2103,the surface carboxyl number of synthesized magnetic polymer microspheres can reach to 0.505 8 mmol/g.At last,chemical structure of the product was characterized by IR.",
        "keywords": [
            "magnetic polymer microspheres",
            "carboxyl groups",
            "dispersion polymerization"
        ],
        "authors": [
            {
                "name": "GU Yu",
                "org": "Qian\u2019an College,Hebei United University,Hebei Qianan ,China"
            }
        ],
        "venue": "Liaoning Chemical Industry",
        "year": 2013
    },
    "joC1WXlY": {
        "id": "joC1WXlY",
        "title": "Characterization of Magnetic Polymer Microspheres with Surface Carboxyl Groups",
        "abstract": "To synthesize the magnetic polymer microspheres with surface carboxyl groups by the dispersion polymerization method in the presence of Fe3O4-KH-570.To test the properties of magnetic polymer microspheres as the core using the analysis technology of UV,FT-IR,SEM and TEM.The results showed that the size of magnetic polymer microspheres was about 350 nm,the microspheres had good magnetic-sensitive and had the obvious core-shell structured.",
        "keywords": [
            "carboxyl group",
            "magnetic polymer microsphere",
            "Fe3O4 particle"
        ],
        "authors": [
            {
                "name": "GU Yu",
                "org": "Qian'an College,Hebei United University,Qianan,,China"
            },
            {
                "name": "YU Ning",
                "org": "Qian'an College,Hebei United University,Qianan,,China"
            }
        ],
        "venue": "Hebei Chemical Industry",
        "year": 2013
    },
    "OndgphbF": {
        "id": "OndgphbF",
        "title": "Study on the Dispersion and Classification of Cu nano-Powder in Ethanol",
        "abstract": "To study dispersion and stability of Cu nano-powder in ethanol under different mass of PVP by the method of absorbency and adding acetone solution to reach the aim of classification.The results showed that when the addition of PVP was 0.05 g,the dispersion and stability of the nano-Cu-ethanol suspensions was best and could provide a steady presence for one week.Under these conditions,adding 20 mL acetone solution step by step,PVP adsorbed layer thickness was reduced,and to obtain powder of different particle sizes,a single dispersion of nano-powder.",
        "keywords": [
            "absorbency",
            "dispersion",
            "classification",
            "stability",
            "Cu nano-powder"
        ],
        "authors": [
            {
                "name": "DENG Xiao-Chen",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "SHI Xiao-ge",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "BAI Di-si",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "Gu Yu",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "LIU Li-wei",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "YUE Li-xi",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "ZHOU Jian-hui",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            }
        ],
        "venue": "Hebei Chemical Industry",
        "year": 2012
    },
    "1sHpWPgW": {
        "id": "1sHpWPgW",
        "title": "Surface Modification of Hydrophilic Fe_3O_4 Nano-particles",
        "abstract": "To use three kinds of silane coupling agents KH-550\u3001KH-560 and KH-570 to modify the surface of Fe3O4 nano-particles,and to prove the coupling agent KH-570 was the best one.To find the optimal conditions were that silane coupling agent dosage was 10%,solution pH value was 6,hydrolysis time was 1 h,reaction temperature was 80 \u2103.And to produce the magnetic microspheres in the best conditions.To test the properties of modified Fe3O4 nano-particles using FT-IR and SEM.The results showed that the silane coupling agent could be effectively modified Fe3O4 nano-particles.",
        "keywords": [
            "Fe3O4 nano-particle",
            "silane coupling agent",
            "surface modification",
            "property"
        ],
        "authors": [
            {
                "name": "GU Yu",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "HOU Cai-xia",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "GAO Peng-fei",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "DENG Xiao-chen",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            }
        ],
        "venue": "Hebei Chemical Industry",
        "year": 2013
    },
    "7wWMTfvM": {
        "id": "7wWMTfvM",
        "title": "Nano-particle Probe and Application of Biological Analysis",
        "abstract": "The definition,principle and classification of nano-particle probe were introduced.Furthermore,the use of DNA detection,protein analysis and deliver drugs were reviewed.The advantages and disadvantages of nano-particle probe were also summarized,such as amplify detection signal,avoid deterioration of protein and reduce the negative effects.And the developments of future nano-particle probe in the aspect of targeted drug delivery and multi-functional analysis were also discussed.",
        "keywords": [
            "sensitivity",
            "nano-particle probe",
            "biological analysis"
        ],
        "authors": [
            {
                "name": "GU Yu",
                "org": "College of Chemical Engineering and Biotechnology,Hebei Polytechnic University,Tangshan ,Hebei,China"
            },
            {
                "name": "HOU Cai-xia",
                "org": "College of Chemical Engineering and Biotechnology,Hebei Polytechnic University,Tangshan ,Hebei,China"
            },
            {
                "name": "HAN Li-hua",
                "org": "College of Chemical Engineering and Biotechnology,Hebei Polytechnic University,Tangshan ,Hebei,China"
            },
            {
                "name": "LIANG Ying-hua",
                "org": "College of Chemical Engineering and Biotechnology,Hebei Polytechnic University,Tangshan ,Hebei,China"
            }
        ],
        "venue": "Journal of Materials Engineering",
        "year": 2010
    },
    "VnSHdvJO": {
        "id": "VnSHdvJO",
        "title": "Characterization of Magnetic Nanoparticles KH-570-Fe_3O_4",
        "abstract": "KH-570 was used to modify the surface of Fe3O4 nano-particles.The analysis technology of FT-IR and SEM were used to test the properties of modified Fe3O4 nano-particles.The result showed that the silane coupling agent KH-570 can be effectively modified Fe3O4 nano-particles.At the same time,the modified nanoparticles had good magnetic-sensitive,and its average size was about 50 nm.On the basis of the modification,magnetic polymer microspheres were prepared by dispersion polymerization.",
        "keywords": [
            "magnetic polymer microspheres",
            "silane coupling agent KH-570",
            "surface modification",
            "Fe3O4 nano-particles"
        ],
        "authors": [
            {
                "name": "GU Yu",
                "org": "Qian'an College,Hebei United University,Hebei Qian'an ,China"
            },
            {
                "name": "BAI Di-si",
                "org": "Qian'an College,Hebei United University,Hebei Qian'an ,China"
            },
            {
                "name": "SHI Xiao-ge",
                "org": "Qian'an College,Hebei United University,Hebei Qian'an ,China"
            },
            {
                "name": "DENG Xiao-chen",
                "org": "Qian'an College,Hebei United University,Hebei Qian'an ,China"
            }
        ],
        "venue": "Guangzhou Chemical Industry",
        "year": 2013
    },
    "9GKatKwp": {
        "id": "9GKatKwp",
        "title": "Effect of Particle Size of Poor Caking Coal on Coking Property",
        "abstract": "Two high rank coals(lean coal and meager lean coal) were carbonized with fat coal by mass ratio of 3/7.With adjust the size of the high rank coal through crucible coking,the influence of particle size of high rank coal on the quality of coke and coke micro-structure was investigated.The results show that with a decrease in the coal particle size,SSI,PRI and PSR of the coke increase.The influence of coal particle size on coke optical texture content is insignificant,but the influence of coal size on coke pore texture is obvious.",
        "keywords": [
            "particle size",
            "coke structure",
            "coal",
            "poor caking"
        ],
        "authors": [
            {
                "name": "CHEN Jun-an",
                "org": "School of Chemical Engineering,Hebei United University,Tangshan ,Hebei,China"
            },
            {
                "name": "GU Yu",
                "org": "School of Chemical Engineering,Hebei United University,Tangshan ,Hebei,China"
            },
            {
                "name": "YAN Li-qiang",
                "org": "School of Chemical Engineering,Hebei United University,Tangshan ,Hebei,China"
            },
            {
                "name": "CUI Wen-quan",
                "org": "School of Chemical Engineering,Hebei United University,Tangshan ,Hebei,China"
            },
            {
                "name": "XIE Quan-an",
                "org": "School of Chemical Engineering,Hebei United University,Tangshan ,Hebei,China"
            },
            {
                "name": "LIANG Ying-hua",
                "org": "School of Chemical Engineering,Hebei United University,Tangshan ,Hebei,China"
            }
        ],
        "venue": "Iron & Steel",
        "year": 2013
    },
    "rquUblXB": {
        "id": "rquUblXB",
        "title": "Advance of New Research on Multi-drug Resistance of Tumor Cells",
        "abstract": "With the frequently use of conventional chemotherapeutic agents,tumor cells become resistant to chemotherapy,the effect of therapeutic was greatly reduced.Thus,the recent researches are finding out the mechanism of multi-drug resistance of tumor cells new antitumor drugs with high therapeutic indices in vivo,low selective toxicity and novel mechanism of action in tumor treatment.",
        "keywords": [
            "muti-drug resistance",
            "tumor cell"
        ],
        "authors": [
            {
                "name": "LIU Li-wei",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "DENG Lei",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "DENG Xiao-chen",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "SHI Xiao-ge",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "BAI Di-si",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            },
            {
                "name": "GU Yu",
                "org": "Qian'an College,Hebei United University,Qian'an ,China"
            }
        ],
        "venue": "Hebei Chemical Industry",
        "year": 2012
    },
    "caugy4ha": {
        "id": "caugy4ha",
        "title": "Two-step method for estimating the RTK system delay using known reference point",
        "abstract": "The position sampling and echo sampling system are not synchronized,when the RTK is used in the Synthetic Aperture Radar imaging process.The delay error of RTK system is also analyzed,which is divided into a fixed delay and a random delay.In this paper a practical method used for estimating this delay is presented.It makes use of the position information of the known reference point to accumulate the echoes and get the fixed delay quickly.Within the result,further random delay is estimated by comparing the image's ISLR.Finally the validity of this method is proved by simulation and real data.",
        "keywords": [
            "time registration",
            "delay estimation",
            "RTK system",
            "motion compensation",
            "back-projection algorithm"
        ],
        "authors": [
            {
                "name": "LI Yang-huan",
                "org": "The College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "The College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "JIN Tian",
                "org": "The College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "The College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Science of Surveying and Mapping",
        "year": 2010
    },
    "C3EvV97t": {
        "id": "C3EvV97t",
        "title": "Extraction of landmine scattering structure based on compressed sensing",
        "abstract": "Based on the sparse characteristics the Compressed Sensing(CS) technique can achieve the sparse image and scattering structure of the target.In this paper the CS technique is applied in the Vehicle-mounted Stepped-frequency Forward-looking Ground-penetrating Virtual Aperture Radar(SFGPVAR) system as well.The electromagnetic model of the landmine can approximate to be a symmetrical cylinder with isotropic characteristic.Based on analyzing the results of simulations and experiments the metal landmine has the structure of two isolate point scatters.This satisfies the sparseness required by the CS in the imaging space,and as a result of that the structure of landmine can be extracted by the CS algorithm.At the end of this paper the feasibility of the CS algorithm on the scattering structures extraction of the landmine and the stability of the landmine feature with two point scatters are proved by the experiment data from the SFGPVAR system.This novel approach not only extends a new way for the feature extraction of landmine,but also discovers a new approach of detection and classification for the targets with simple scattering structures.",
        "keywords": [
            "Virtual aperture radar",
            "Electromagnetic model of landmine",
            "Ultra wide band",
            "Compressed sensing"
        ],
        "authors": [
            {
                "name": "WANG Peng-yu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "SONG Qian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "JIN Tian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2012
    },
    "lSxhDfNi": {
        "id": "lSxhDfNi",
        "title": "An Improved RDM Algorithm for UWB SAR",
        "abstract": "An new Extended Reflectivity Displacement Method(ERDM)algorithm for UWB SAR is presented in this paper.This new method overcomes the disadvantage of long synthetic aperture and great range migration for UWB SAR and extends the RDM appli- cability.The results of simulation show that the method can work effectively.",
        "keywords": [
            "RDM",
            "ERDM",
            "UWB SAR"
        ],
        "authors": [
            {
                "name": "XUE Guo-yi",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2008
    },
    "y7zP1b6K": {
        "id": "y7zP1b6K",
        "title": "Fast Detection of Ground Penetrating Radar Objects Based on Cross Correlation and Hough Transform",
        "abstract": "Considering the issue of low computation efficiency of Ground Penetrating Radar(GPR) object detection method,a fast algorithm is proposed based on the spatial distribution of reflected energy,which is modeled as a three-parameter hyperbola.A reflection hyperbola is first extracted by utilizing the correlation between adjacent reflections.Being weighted with reflection energy,the hyperbola is then fitted to estimate the two parameters of the reflected model.Finally,the object detection and localization task is completed with one dimensional Hough transform.The efficiency of the proposed algorithm is demonstrated both theoretically and experimentally.Compared with the traditional algorithm based on Hough transform,the proposed algorithm consumes only 1.5% computational time without sacrificing the detection and localization performance.",
        "keywords": [
            "Ground Penetrating Radar(GPR)",
            "Cross correlation",
            "Hough transform",
            "Objects detection"
        ],
        "authors": [
            {
                "name": "Wang Jian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Yuan Xiao",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Li Yu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Huang Chun-lin",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Su Yi",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2013
    },
    "DhSEJ1Ce": {
        "id": "DhSEJ1Ce",
        "title": "A Motion Compensation Technique Based on GPS and Refined MapDrift for Ultra-Wide Band SAR",
        "abstract": "Traditional motion compensation for airborne SAR based on hardware requires motion-measurement and navigation sys- tem with high-accuracy,which is expensive.Based on the character that attitude information of aircraft is unnecessary for UWB SAR,a new motion compensation method combining real-time GPS and our Refined MapDrift(MD)is proposed in this paper.The GPS informa- tion is used to correct most of the motion error of aircraft,that is to say,the GPS position data is used to correct range delay of SAR echo, and the GPS velocity data is used to correct most of phase error.After coarse compensation by GPS,the residual phase error is corrected by our Refined MD.The new method is verified by real UWB-SAR data image and is very attractive for UWB-SAR for its cheapness.",
        "keywords": [
            "uwb-sar",
            "refined mapdrift",
            "gps",
            "motion compensation",
            "global positioning system",
            "synthetic aperture radar",
            "real time",
            "ultra wide band"
        ],
        "authors": [
            {
                "name": "XUE Guo-yi",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            },
            {
                "name": "HUANG Xiao-tao",
                "org": "Electronic Science and Engineering Institute,NUDT,Changsha ,China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2007
    },
    "nhbKP4FD": {
        "id": "nhbKP4FD",
        "title": "Compensation of Archimedean-spiral Antenna Group Delay and UWB-SAR System Delay",
        "abstract": "The group delay of the Archimedean-spiral antenna was cataloged into the dispersion part and the constant part.Then a geometrical analysis was used to reveal the inherent dispersion property of the antenna's group delay.As a result,it effectively compensated the unknown antenna with its geometry measured.The constant group delay of the antenna was added into the system delay as a whole,and the whole delay was estimated through the Hough transformation of the hyperbola of a calibration marker(e.g.trihedral),as one of the curve parameters is the system delay.By an estimation of the azimuth location of the nadir of the curve using its symmetrical property,the dimension of the Hough transformation is further eliminated,so the method is efficient.Rail Ultra Wide Band SAR(UWB-SAR) data processing result verified the compensation method.",
        "keywords": [
            "Archimedean-spiral antenna",
            "Dispersion compensation",
            "Hough transformation",
            "UWB-SAR"
        ],
        "authors": [
            {
                "name": "WANG Jian",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhimin Zhou",
                "org": "National University of Defense Technology(National University of Defense Technology,National Univ. of Defense Technology),Changsha,China"
            },
            {
                "name": "SONG Qian",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of National University of Defense Technology",
        "year": 2008
    },
    "cTQekxkW": {
        "id": "cTQekxkW",
        "title": "Fast Factorized Backprojection Algorithm for Vehicle-mounted Forward-looking Ground Penetrating SAR",
        "abstract": "The vehicle-mounted forward-looking ground penetrating SAR(VMFL-GPSAR) is a kind of bistatic SAR.Fast factorized backprojection(FFBP) originally developed for unistatic SAR fails to efficiently form well-focused VMFL-GPSAR image.A bistatic FFBP algorithm is derived after the analysis of the round trip range error of FFBP in VMFL-GPSAR.In the bistatic FFBP,the range error can be reduced by rational subaperture center configuration and by polar angle interval constraint.Besides,by combining range phase compensation and 2D linear interpolation,the bistatic FFBP can perform faster with the same focus precision.Simulation and VMFL-GPSAR raw data processing validate the bistatic FFBP algorithm,achieving a 2.31 times speedup.",
        "keywords": [
            "real-time image formation",
            "FFBP",
            "bistatic",
            "ground penetrating SAR",
            "forward-looking"
        ],
        "authors": [
            {
                "name": "WANG Jian",
                "org": "College of Electronics Science and Technology,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHANG Han-hua",
                "org": "College of Electronics Science and Technology,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "College of Electronics Science and Technology,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "SONG Qian",
                "org": "College of Electronics Science and Technology,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "JIN Tian",
                "org": "College of Electronics Science and Technology,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of National University of Defense Technology",
        "year": 2009
    },
    "XYhhxjjz": {
        "id": "XYhhxjjz",
        "title": "Contrast Optimization Autofocus Algorithm for UWB SAR",
        "abstract": "Unlike synthetic aperture radar(SAR) operating on high band, there exists very strong clutter and noise in ultra-wide Band SAR (UWB SAR) working on UHF/VHF band, which makes it difficult for the application of contrast optimization autofocus (COA) algorithm in UWB SAR. The strong clutter sometimes would make the image contrast cannot really reflect whether targets focus or not. The effects of the COA algorithm are decided by minishing the interference of clutter somewhat. In this paper, some techniques are used to overcome the disadvantages of strong clutters and the results of real UWB SAR data show the validity of the improved COA.",
        "keywords": [
            "autofocus",
            "contrast optimization",
            "motion compensation",
            "UWB SAR"
        ],
        "authors": [
            {
                "name": "XUE Guo-yi",
                "org": "School of Electronic Science and Engineering, NUDT, Changsha , China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "School of Electronic Science and Engineering, NUDT, Changsha , China"
            },
            {
                "name": "WANG Jian",
                "org": "School of Electronic Science and Engineering, NUDT, Changsha , China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2007
    },
    "bBybMfdk": {
        "id": "bBybMfdk",
        "title": "A New Subaperture Nonlinear Chirp Scaling Algorithm for Real-Time UWB-SAR Imaging",
        "abstract": "This paper presents a subaperture Nonlinear Chirp Scaling(NCS)algorithm for real-time Ultra-Wide Band SAR (UWB-SAR)imaging.Based on one-to-one correspondence of frequency and time,the nonoverlapped subapertures are formed in the time domain at the beginning of the process.The nonoverlapped subapertures result in a decrease in memory requirement and computa- tional load,and result in a pair of ghosts.Fortunately,we suggest a window weighting technique which depresses the paired ghosts to -31 dB.Beside this,the MapDrift autofocus technique is incorporated to compensate the complex motion error along the large aperture. The vitality of the algorithm is demonstrated by simulation and real UWB-SAR image formation.",
        "keywords": [
            "ultra-wide band sar",
            "subaperture",
            "nonlinear chirp scaling algorithm",
            "motion compensation",
            "process simulation",
            "real time",
            "radar imaging",
            "image formation",
            "nonlinear systems",
            "image resolution",
            "error correction",
            "synthetic aperture radar",
            "radar tracking",
            "high resolution",
            "real time systems"
        ],
        "authors": [
            {
                "name": "WANG Jian",
                "org": " School of Electronics Science and Technology,National University of Defense Technology,Changsha,,China"
            },
            {
                "name": "XUE Guo-yi",
                "org": " School of Electronics Science and Technology,National University of Defense Technology,Changsha,,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": " School of Electronics Science and Technology,National University of Defense Technology,Changsha,,China"
            },
            {
                "name": "SONG Qian",
                "org": " School of Electronics Science and Technology,National University of Defense Technology,Changsha,,China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2008
    },
    "uTrUXRx2": {
        "id": "uTrUXRx2",
        "title": "Research on Phase Compensating Factors in Chirp Scaling Algorithm",
        "abstract": "In this paper the two-dimensional frequency expression of SAR echoes are first analyzed. Then, the standard chirp scaling algorithm and its several modified forms used both in high frequency narrow band SAR and low frequency Ultra WideBand (UWB) SAR are compared in a united frame of two-dimensional frequency expression. The approximations made by different algorithms are evaluated in detail. So a new depiction for SAR image formation is proposed, which is a process of constructing phase compensating factors in frequency or time domain according to the characteristics of echo spectrum. Especially, the accuracy of phase compensating factors for UWB SAR echoes has a direct impact on point targets focusing. Simulation results verify that the modified non-linear chirp scaling algorithm, which can compensate the more third orders phase coupling, can arrive an ideal focusing UWB SAR image in the certain of scope. Further more, the algorithm has been used successfully in raw UWB SAR data processing.",
        "keywords": [
            "CS algorithms",
            "2D spectrum",
            "Phase compensating factor",
            "SAR imaging",
            "UWB SAR imaging"
        ],
        "authors": [
            {
                "name": "Wang Liang",
                "org": "Dept. of Electronic Technology, NUDT, Changsha , China"
            },
            {
                "name": "Wang Jian",
                "org": "Dept. of Electronic Technology, NUDT, Changsha , China"
            },
            {
                "name": "Huang Xiao-tao",
                "org": "Dept. of Electronic Technology, NUDT, Changsha , China"
            },
            {
                "name": "Zhou Zhi-min",
                "org": "Dept. of Electronic Technology, NUDT, Changsha , China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2007
    },
    "5aouhVaP": {
        "id": "5aouhVaP",
        "title": "A Novel Adaptive Suppression Method of Interferences in the Vehicle-mounted UWB SAR System",
        "abstract": "With an analysis of the types and formation mechanism of interferences in the vehicle-mounted ultra-wideband synthetic aperture radar(UWB SAR) detection system,a novel adaptive method is presented for the interferences suppression in the image domain based on the iterative technique.It can overcome the limitations and drawbacks of a batch processing method proposed by Tsaipei Wang.By exploiting the constant false alarm rate(CFAR) detector with weibull distribution,the new method can improve the accuracy of interference estimation.Then the parameters estimation and updating can be realized by using the iterative operation,and the adaptive interference suppression can be achieved on line.The processing results of real data show that the proposed method can effectively suppress the self-signature interference and is prone to real-time processing in structure.It can meet the needs of real-time preprocessing in the vehicle-mounted UWB SAR detection system.",
        "keywords": [
            "adaptive interference suppression",
            "ground penetrating radar(GPR)",
            "synthetic aperture radar(SAR)",
            "iterative operation",
            "image preprocessing"
        ],
        "authors": [
            {
                "name": "YANG Yan-guang",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "SONG Qian",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            },
            {
                "name": "JIN Tian",
                "org": "College of Electronic Science and Engineering,National Univ.of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of National University of Defense Technology",
        "year": 2008
    },
    "hfnyPvHY": {
        "id": "hfnyPvHY",
        "title": "Scattering from Buried Dielectric Landmine with Metal Fuze",
        "abstract": "This paper analyses scattering from dielectric landmines with metal fuze buried in a lossy, dispersive half space using equivalent theory. The calculations are performed using a Method of Moments (MoM) algorithm for bodies of revolution. In the end, this paper compares the theoretical results and the experimental results collected by the vehicle-mounted ground penetrating synthetic aperture radar (GP-SAR). The agreement is good, which shows that the algorithm is efficient.",
        "keywords": [
            "Dielectric landmines with metal fuze",
            "Method of moments(MoM)",
            "Electromagnetic scattering"
        ],
        "authors": [
            {
                "name": "SUN Xiao-kun",
                "org": "School of Electronic Science and Engineering, National University of Defense Technology, Changsha , China"
            },
            {
                "name": "WANG Jian",
                "org": "School of Electronic Science and Engineering, National University of Defense Technology, Changsha , China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "School of Electronic Science and Engineering, National University of Defense Technology, Changsha , China"
            }
        ],
        "venue": "Journal of Microwaves",
        "year": 2008
    },
    "K42CzaHl": {
        "id": "K42CzaHl",
        "title": "Scattering from Buried Metal Landmines",
        "abstract": "The false alarms in landmine detection is the main problem of the practicality of ultra-wideband(UWB) synthetic aperture radar(SAR).To reduce the false alarms,the detector should be designed based on the electromagnetic characteristics of landmines.Regarding landmines as a pair of cylinders,this paper analyses scattering from landmines buried in a lossy,dispersive half space.The calculations are performed using a Method of Moments(MoM) algorithm for bodies of revolution.In the end,this paper compares the theoretical results and the experimental results collected by the Rail ground penetrating SAR.The agreement is good,which shows that the algorithm is very efficient.",
        "keywords": [
            "Landmines",
            "Method of moments",
            "Electromagnetic scattering"
        ],
        "authors": [
            {
                "name": "SUN Xiao-kun",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Microwaves",
        "year": 2008
    },
    "pa5EFzeG": {
        "id": "pa5EFzeG",
        "title": "A Novel Adaptive Interferences Suppression and Background Uniformization Method Applicable to FLGPSAR System",
        "abstract": "To solve the problems of the self-signature interference and the nonuniformity of image background existing in the vehicle-mounted Forward-Looking Ground Penetrating Synthetic Aperture Radar(FLGPSAR) detection system,an adaptive method is proposed to realize interferences suppression and background uniformi-zation based on distance-band partition and iterative operation techniques in the image domain.Parallel proc-essing can be realized via distance-band partition,which can also improve the accuracy of parameters estimation.Parameters can be estimated and updated on line by using the iterative operation technique,and then the in-terference suppression and background gain uniformization can be adaptively achieved.Experimental results of the real data show that proposed method has a better adaptability to environment and is prone to real-time processing in structure.It can effectively meet the needs of the vehicle-mounted FLGPSAR system for image preprocessing.",
        "keywords": [
            "Adaptive interference suppression",
            "Ground Penetrating Radar(GPR)",
            "Image preprocessing",
            "Synthetic Aperture Radar(SAR)",
            "Distance-band partition",
            "Iterative operation"
        ],
        "authors": [
            {
                "name": "Yang Yan-guang",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Song Qian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Jin Tian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Wang Jian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhou Zhi-min",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2009
    },
    "0hYqRRQe": {
        "id": "0hYqRRQe",
        "title": "An Approach for Suppressing Sidelobes of Strong Clutters in Echo Domain Based on APES",
        "abstract": "This paper proposes a new approach of suppressing sidelobes based on APES in the case that sidelobes of strong targets alias into outside SAR viewing area and adverse impact on weak targets detection can be made.Strong clutters outside viewing area need to be suppressed.The locations of strong clutters are determined based on the shape of their hyperbolic curves in echo domain.The scattering coefficients of strong clutters are estimated by APES and then suppressed in echo domain.SAR images generated from suppressed echoes can avoid the adverse impact of strong clutters on weak targets detection effectively.Experimental results show the effectiveness of the approach.",
        "keywords": [
            "amplitude and phase estimation(apes)",
            "strong clutters",
            "echo domain",
            "sidelobe suppression",
            "weak targets",
            "radar tracking",
            "imaging",
            "radar imaging",
            "clutter",
            "synthetic aperture radar",
            "estimation",
            "azimuth",
            "scattering",
            "image reconstruction",
            "apes"
        ],
        "authors": [
            {
                "name": "HUANG Lu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology, Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology, Changsha ,China"
            },
            {
                "name": "SONG Qian",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology, Changsha ,China"
            }
        ],
        "venue": "Radar Science and Technology",
        "year": 2011
    },
    "cPRyNhBg": {
        "id": "cPRyNhBg",
        "title": "An Adaptive 2D Sidelobe Suppression Technique for SAR Image",
        "abstract": "A separable 2-dimensional Adaptive Sidelobe Reduction(ASR) technique is presented after analyzing the characteristics of sidelobes in SAR image.The principle of the technique is to suppress the sidelobe along its lying directions.The technique can efficiently lower the nonorthogonal sidelobes in Ultra-Wide Band SAR image and the rotated sidelobes in squint SAR image.The performance of the separable 2D ASR is slightly superior to that of the jointly 2D ASR.Additionally,the former is computational more effective. Simulation and real image processing performance validate the separable 2D ASR.",
        "keywords": [
            "Adaptive Sidelobe Reduction",
            "Rotated Sidelobe",
            "Nonorthogonal Sidelobe"
        ],
        "authors": [
            {
                "name": "WANG Jian",
                "org": "School of Electronics Science and Technology,NUDT,Changsha,,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "School of Electronics Science and Technology,NUDT,Changsha,,China"
            },
            {
                "name": "SONG Qian",
                "org": "School of Electronics Science and Technology,NUDT,Changsha,,China"
            },
            {
                "name": "JIN Tian",
                "org": "School of Electronics Science and Technology,NUDT,Changsha,,China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2009
    },
    "8Y8BLgjU": {
        "id": "8Y8BLgjU",
        "title": "SAR imaging using Fast Factorized Backprojection based on Optimal Regional Partition",
        "abstract": "This paper presents a study of an improved SubImage based variants of the time domain Synthetic Aperture Radar (SAR) algorithm Fast Factorized Backprojection (FFBP). Sub-Image FFBP based on Optimal Regional Partition (ORP) (SIFFBP-ORP) algorithm is proposed by analyzing the regional division constraints. It provides a way to solve the acceleration-decline problem of the conventional SIFFBP algorithm when the SAR system has a small integration angle. The result of SIFFBP-ORP algorithm shows that it is faster than traditional SIFFBP with reduction computational time of about 7 times.",
        "keywords": [
            "radar imaging",
            "synthetic aperture radar",
            "time-domain analysis",
            "sar imaging",
            "siffbp-orp algorithm",
            "acceleration-decline problem",
            "fast factorized backprojection",
            "improved subimage based variant",
            "optimal regional partition",
            "regional division constraint",
            "time domain synthetic aperture radar algorithm"
        ],
        "authors": [
            {
                "name": "Jiang Xiaolong",
                "org": "Coll. of Electron. Sci. & Eng., Nat. Univ. of Defense Technol., Changsha, China|c|"
            },
            {
                "name": "Wang Jian",
                "org": ""
            },
            {
                "name": "Song Qian",
                "org": ""
            },
            {
                "name": "Zhou Zhimin",
                "org": ""
            }
        ],
        "venue": "Cincinnati, OH",
        "year": 2014
    },
    "NGCaRk9L": {
        "id": "NGCaRk9L",
        "title": "Signal Based Motion Compensation for Ultra-wide Band SAR",
        "abstract": "This paper presents a signal based Doppler rate estimation and compensation method to form a well focused Ultra-Wide Band Synthetic Aperture Radar(UWB-SAR)image.A refined MapDriftt(MD)autofocus technique is promoted to improve its original performance in UWB-SAR.In the refined MD,some implementation skills are adopted to accommodate the \u201cbroadside sparking\u201d and the long aperture.Further more,the estimated Doppler rate error is interpolated and compensated in an iteration manner.As a result,higher order phase errors are compensated and this enable the refined MD technique to be capable in applications with large motion error,for example in UAV SAR.Finally the refined MD technique is verified by real UWB-SAR data imaging.",
        "keywords": [
            "Motion compensation",
            "UWB-SAR",
            "Autofocus",
            "MapDrift"
        ],
        "authors": [
            {
                "name": "Wang Jian",
                "org": "School of Electronics Science and Technology,NUDT,Changsha ,China"
            },
            {
                "name": "Wang Liang",
                "org": "School of Electronics Science and Technology,NUDT,Changsha ,China"
            },
            {
                "name": "Xue Guo-yi",
                "org": "School of Electronics Science and Technology,NUDT,Changsha ,China"
            },
            {
                "name": "Zhou Zhi-min",
                "org": "School of Electronics Science and Technology,NUDT,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2007
    },
    "bW5puFgy": {
        "id": "bW5puFgy",
        "title": "A Study on a SFCW Forward-looking Ground Penetrating Radar",
        "abstract": "A stepped frequency continuous wave forward-looking ground penetrating radar is developed,which can perform real time synthetic aperture imaging of shallow buried targets over large areas ahead.The number of receive antennas is halved using two transmit antennas to achieve the same azimuth aperture.An frequency equalizer,a reference receive channel and digital IF receiver is used to achieve good transfer characteristic of the ultra wide band system.The direct coupling of T/R antennas is cancelled at intermediate frequency.The bistatic fast back projection technique is proposed to focus synthetic aperture echoes.Experimentation results show that real time images of shallow buried targets can be provided.",
        "keywords": [
            "stepped frequency continuous wave radar",
            "synthetic aperture imaging",
            "ground penetrating radar"
        ],
        "authors": [
            {
                "name": "LU Bi-ying",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "SONG Qian",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2010
    },
    "B7q1h0BD": {
        "id": "B7q1h0BD",
        "title": "Analysis and modeling of GPS error under circumstances of fast motion",
        "abstract": "The characteristics of GPS error under the circumstances of fast motion are different from that of static circumstances.A method is presented which is used to analyze the GPS error in this paper.At first,the GPS measurement error is separated by polynomial fitting,and the method separating GPS error is validated by SAR image,and then the model of GPS error is erected by signal processing.Some airborne GPS data are analyzed using the method presented here,and the result shows that the GPS velocity and position error model are two different stochastic processes of 10th AR(autoregressive) model in our condition.",
        "keywords": [
            "SAR",
            "fast motion",
            "GPS",
            "signal processing",
            "AR model"
        ],
        "authors": [
            {
                "name": "XUE Guo-yi",
                "org": "Electronic Science and Engineering Institute,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHOU Zhi-min",
                "org": "Electronic Science and Engineering Institute,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Jian",
                "org": "Electronic Science and Engineering Institute,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Chinese Inertial Technology",
        "year": 2006
    },
    "72pbgTZs": {
        "id": "72pbgTZs",
        "title": "Modified Frequency Scaling Imaging Algorithm of Ultra-Wideband SAR",
        "abstract": "This paper presents a modified Frequency Scaling (FS) algorithm for low frequency Ultra-Wideband (UWB) airborne SARs with dechirped receivers. Compared with the original FS algorithm, two modifications are made. One is that the modified FS algorithm gets rid of the Taylor-approximation of the echoes in the range Doppler domain, and this operation leads to a precision Secondary Range Compression(SRC) and Range Cell Migration Correction (RCMC) at the reference range. The other one is that the modified FS algorithm introduces a phase correction function before the azimuth compression in the two-dimensional frequency domain. As a result, the residual phase error caused by the SRC factor without range updating is reduced, so the focusing performance is dramatically improved and the effective swath width is enlarged. Moreover the modified FS Algorithm doesn't require additional computations. Simulations demonstrate that the first modification realizes precision focus of small swath UWB SAR data and that an improvement of effective swath width 20 times of the former is achieved by the second modification.",
        "keywords": [
            "frequency scaling",
            "secondary range compression",
            "ultra-wideband"
        ],
        "authors": [
            {
                "name": "Wang Jian",
                "org": "School of Electronics Science and Technology, National University of Defense Technology, Changsha, , China"
            },
            {
                "name": "Song Qian",
                "org": "School of Electronics Science and Technology, National University of Defense Technology, Changsha, , China"
            },
            {
                "name": "Zhou Zhimin",
                "org": "School of Electronics Science and Technology, National University of Defense Technology, Changsha, , China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2005
    },
    "FOpHp8d1": {
        "id": "FOpHp8d1",
        "title": "Improve the radiation efficiency of bow-tie antenna by exploiting the energy in end reflections",
        "abstract": "The bow-tie antenna,which is widely used in impulse ground penetrating radar(GPR),has very low radiating efficiency.It is because that nearly 70% of the radiated energy exists as the form of end reflection,which is obstructive to probing objects.In order to keep the probing ability,the remarkable energy in end reflections is usually dissipated by resistive loading.Through the current research,it was found that,if the exciting pulse is bipolar and monocycle,the radiation efficiency can be significantly improved by utilizing the energy in end reflection,and the improvement can be implemented by optimizing the antenna length.The simulated results show that the radiation efficiency can be increased by nearly 100%.The measured results validate the proposed method again.Additionally,the proposed method is easy to be carried out in applications and of great use.",
        "keywords": [
            "ground penetrating radar(GPR)",
            "bow-tie antenna",
            "radiation efficiency",
            "end reflections"
        ],
        "authors": [
            {
                "name": "WANG Jian",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "HUANG Chunlin",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LU Min",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LI Yu",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "SU Yi",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of National University of Defense Technology",
        "year": 2013
    },
    "PFfAy7bb": {
        "authors": [
            {
                "name": "Lan Wang",
                "org": "Department of Electronic Engineering"
            },
            {
                "name": "Zhisheng Niu",
                "org": "Department of Electronic Engineering"
            },
            {
                "name": "Yanfeng Zhu",
                "org": "Department of Electronic Engineering"
            },
            {
                "name": "Hui Deng",
                "org": "R and D Center Hitachi(China) Ltd."
            },
            {
                "name": "Masashi Yano",
                "org": "Central Research Laboratory"
            }
        ],
        "title": "Integration of SNR, load and time in handoff initiation for wireless LAN",
        "abstract": "The performance of handoff initiation algorithm is one of the key issues for providing roaming capability in wireless LAN (WLAN). In this paper, we propose a new handoff initiation algorithm for data transmitting in WLAN. Our proposal combines association time, system load and signal/noise ratio (SNR) together to decide whether mobile node should handoff or not. The goal is to reduce the number of unnecessary handoff, decrease packet loss and balance the system load. In this way, we can provide quality of service (QoS) guarantee. Simulation results show that the proposed handoff initiation algorithm is efficient in WLAN. \u00a9 2003 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, PIMRC",
        "year": 2003,
        "id": "PFfAy7bb"
    },
    "AC2qlz3m": {
        "id": "AC2qlz3m",
        "title": "Effect of CaCl_2 on Quality of Pitaya Fruits under Cold Storage",
        "abstract": "The fruits of Hylocereus undatus were treated by CaCl2 solution with three different concentrations to study the effect of CaCl2 on quality of pitaya fruits under cold storage.The results showed that CaCl2 treatment had no obvious inhibition effect on respiration of pitaya fruits,but could reduce rotten rate of pitaya fruits to a certain extent,2 %CaCl2 treatment could reduce transpiration rate of pitaya fruits,6 %CaCl2 treatment could delay rotten of pitaya fruits,and there was no significant difference in nutrition quality of pitaya fruits among three treatments during the whole cold storage period.The quality of pitaya fruits treated by 2 % CaCl2 solution was the best among three different CaCl2 concentrations.",
        "keywords": [
            "CaCl2",
            "Cold storage",
            "Quality",
            "Pitaya"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "HE Xu-xiao",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "DENG Ren-ju",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "PENG Yu-ji",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHOU Jun-liang",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2010
    },
    "BGMdwW5m": {
        "id": "BGMdwW5m",
        "title": "Effect of Different Bags on Fruit Quality of Dawuxing,a Loquat Variety",
        "abstract": "The bagging experiment of Dawuxing,a loquat variety,was conducted by using different kinds of bags to study the effect on fruit quality.The results showed that the special fruit bag and kraft bag both could improve the exterior quality and fruit color,maintain intact pubescence,reduce and inhibit fruit rust,raise commerciality and edible rate,the number of sunscald fruits bagged by the plastic bag was higher than CK,and the content of soluble solids and Vc of fruits bagged with different kinds of bags was lower than CK.The comprehensive fruit quality effect of different fruit bags is special fruit bag>kraft bag>plastic bag.",
        "keywords": [
            "loquat",
            "quality",
            "fruit bag",
            "sunscald",
            "kraft paper",
            "bagging",
            "plastics",
            "chemical composition"
        ],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2009
    },
    "9suvTpoC": {
        "id": "9suvTpoC",
        "title": "Toxicity Measurement of Different Fungicides on Pathogen of Pitaya Stem Blight",
        "abstract": "In order to select effective and safe fungicide for pitaya production,indoor toxicity measurement of six fungicides on pathogen of pitaya stem blight was carried by growth-rate method.The results showed that the six fungicides can inhibit pathogen mycelium growth of pitaya stem blight at different levels and the inhibition rate increase along with fungicide concentration's increase.The inhibition rate of different fungicides varies significantly.Toxicity of different fungicides in term of EC50 value drops in turn from 50% Thiram WP to 50% Carbendazim sulfur WP,70% Mancozeb WP,70%Thiophanate methyl WP,42% net Kejunling WP and 75% Chlorothalonil WP The inhibition effect of 50% Thiram WP is best,followed by 50% Carbendazim\u00b7sulfur WP,while 75% Chlorothalonil WP is the worst.",
        "keywords": [
            "toxicity measurement",
            "pitaya",
            "fungicide",
            "stem blight",
            "mycelium",
            "fungicides",
            "growth",
            "toxicity"
        ],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2009
    },
    "rwTsgCfF": {
        "id": "rwTsgCfF",
        "title": "Identification of Zihonglong Pitaya and Its Big-fruit Sport Line by ISSR",
        "abstract": "To uncover the difference between Zihonglong pitaya and big-fruit sport line at DNA level,the genetic identification of Zihonglong pitaya and big-fruit sport line was conducted by using ISSR molecular markers. The results showed that by using the nine primers screened67 reproducible bands were amplified,of which 26 were polymorphic,polymorphic ratio was 38. 8 %; primers 811,835 and 834 could effectively differentiate Zihonglong pitaya and its big-fruit sport line and construct the DNA ISSR fingerprint; the similarity coefficient among tested genetic materials was 0. 6119 according to statistical analysis of genetic diversity by using NTSYSpc 2. 10 e analysis software. Zihonglong pitaya and its big-fruit sport line existed obvious genetic diversity at DNA molecular level,the big-fruit sport line was stable variants of Zihonglong pitaya with the genetic foundation of becoming a new big-fruit cultivar and be protected and utilized as a new-type material. ISSR technology can be used to identify the pitaya bud variation effectively.",
        "keywords": [
            "ISSR analysis",
            "Sport",
            "Pitaya"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": ""
            },
            {
                "name": "ZHENG Wei",
                "org": ""
            },
            {
                "name": "SONG Sha",
                "org": ""
            },
            {
                "name": "LI Xing-zhong",
                "org": ""
            },
            {
                "name": "CAI Yong-qiang",
                "org": ""
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2013
    },
    "iFut7ZiS": {
        "id": "iFut7ZiS",
        "title": "Domestication Cultivation of Smallanthus sonchifolius in the River Valley Region with Low Latitude and Temperature",
        "abstract": "The growth vigor,yield and quality of Smallanthus sonchifolius planted in Luodian County(the river valley region with low latitude and temperature) were analyzed in three years' domestication cultivation to discuss its adaptability in Luodian County.The results showed that Smallanthus sonchifolius can normally grow,develop,flower and set fruits in Luodian County but its fruit yield(975.5 kg/667m2),commerciality and nutrition value is poor.Therefore,Luodian County is the secondary suitable cultivation region for planting Smallanthus sonchifolius.",
        "keywords": [
            "smallanthus sonchifolius",
            "river valley region with low latitude and temperature",
            "domestication cultivation",
            "crop yield",
            "domestication",
            "growth"
        ],
        "authors": [
            {
                "name": "LIU Tao",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "JIN Ji-fen",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "JIN Ji-lin",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2009
    },
    "uud1fdZE": {
        "id": "uud1fdZE",
        "title": "Nutritional Composition of Pitaya Flowers",
        "abstract": "The nutrition composition of filaments,petals and bracts of Jinhonglong(a pitaya variety) was determined to study nutrition composition contents of different parts of pitaya.The results showed that the flower of pitaya is rich in sugars,organic acids,food fiber,protein,different vitamins,potassium,magnesium,calcium and phosphorus,its food fiber and protein content is up to 17.4 % and 15.0 % respectively,and the content of 8 human necessary amino acids accounts for 43.8 % of total amino acids content in its flowers.",
        "keywords": [
            "nutrition composition",
            "analysis",
            "flower",
            "pitaya",
            "corolla",
            "bracts",
            "amino acids",
            "phosphorus",
            "magnesium",
            "chemical composition",
            "potassium",
            "calcium"
        ],
        "authors": [
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2010
    },
    "0fxVBzHt": {
        "id": "0fxVBzHt",
        "title": "DEVELOPMENT OF CHITOSAN ON FRUIT FRESH-KEEPING AND STORAGE",
        "abstract": "Summarizes the present fruit storage chitosan in the application of research. These studies show that: chitosan coating fruit to be effective in extending the commodity; coating thickness and the concentration should be suitable for different types of fruit, and the concentration of its coating thickness not the same. Also on chitosan Storage mechanism was simple exposition.",
        "keywords": [
            "fruit",
            "chitosan",
            "fresh-keeping",
            "storage"
        ],
        "authors": [
            {
                "name": "LI Sheng-hai",
                "org": " Guizhou Fruit Institute,Luodian , Guizhou, China"
            },
            {
                "name": "WANG Bin",
                "org": " Guizhou Fruit Institute,Luodian , Guizhou, China; College of Horticulture and Landscape,Hunan Agricultural University,Changsha , Hunan, China"
            },
            {
                "name": "PENG Yu-ji",
                "org": " Guizhou Fruit Institute,Luodian , Guizhou, China"
            },
            {
                "name": "ZHENG Wei",
                "org": " Guizhou Fruit Institute,Luodian , Guizhou, China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2008
    },
    "4rRXZRVQ": {
        "id": "4rRXZRVQ",
        "title": "Characteristics of the Quality and Physiological Changes of Postharvested Prunus salicina Fruit",
        "abstract": "The principal quality and physiological indexes of P.salicina fruit in Yanhe County were detected to understand the characteristics of the quality and physiological changes of postharvested P.salicina,and promote the industrial development of local characteristic products.The results showed that there was a downward trend generally on the postharvested fruit quality,Vc content and fruit firmness were two indexes that changed significantly.The fruit firmness of P.salicina seven days after harvested was lower than P.salicina one day after harvested by 22.46%.The VC content decreased to the lowest value(0.39 mg/100 g) four days postharvested,only 27.46% of that one day postharvested.The P.salicina fruit was a respiration climacteric fruit with single peak curve.Meanwhile,the variation of respiration rate lagged behind that of ethylene content in P.salicina fruit.",
        "keywords": [
            "physiological changes",
            "postharvest quality",
            "Prunus salicina"
        ],
        "authors": [
            {
                "name": "PENG Yu-ji",
                "org": "Guizhou Fruit Science Institute,Guiyang,Guizhou "
            },
            {
                "name": "HAN Xiu-mei",
                "org": "Guizhou Fruit Science Institute,Guiyang,Guizhou "
            },
            {
                "name": "JIANG Li",
                "org": "Guizhou Fruit Science Institute,Guiyang,Guizhou "
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Science Institute,Guiyang,Guizhou "
            },
            {
                "name": "YANG Fei",
                "org": "Guizhou Fruit Science Institute,Guiyang,Guizhou "
            },
            {
                "name": "WEI Qian",
                "org": "Guizhou Fruit Science Institute,Guiyang,Guizhou "
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2012
    },
    "bQfnMDXM": {
        "id": "bQfnMDXM",
        "title": "Effect of 1-MCP on Quality of Pitaya Fruits under Cold Storage",
        "abstract": "The fruits of Hylocereus undatus were treated by 1-MCP solution with three different concentrations to study the effect of 1-MCP on qua1ity of pitaya fruits under cold storage.The results showed that 1-MCP fumigation of the overall effect than the control,early in storage(0-24 d) to inhibit respiration Pitaya fruit has a certain effect;control after 18 days in storage rot,1-MCP treatment may extend the storage period 3 d-6 d;1-MCP treatment delayed the VC content of titratable acid and a decline in inhibition of reducing sugar content increased significantly delay the dragon fruit quality deterioration during storage.On the whole,0.5 \u03bcL/L and 1.0 \u03bcL/L 1-MCP treatment during cold storage maintain the best fresh fruit.",
        "keywords": [
            "cold storage",
            "1-MCP",
            "quality",
            "Pitaya"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guiyang ,Guizhou,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guiyang ,Guizhou,China"
            },
            {
                "name": "HE Xu-xiao",
                "org": "Guizhou Fruit Institute,Guiyang ,Guizhou,China"
            },
            {
                "name": "LI Sheng-hai",
                "org": "Guizhou Fruit Institute,Guiyang ,Guizhou,China"
            },
            {
                "name": "DENG Ren-ju",
                "org": "Guizhou Fruit Institute,Guiyang ,Guizhou,China"
            },
            {
                "name": "ZHOU Jun-liang",
                "org": "Guizhou Fruit Institute,Guiyang ,Guizhou,China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2012
    },
    "zmTImhwX": {
        "id": "zmTImhwX",
        "title": "Effect of NaCl Stress on Seed Germination of Pitaya",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": ""
            },
            {
                "name": "WANG Bin",
                "org": ""
            },
            {
                "name": "CAI Yong-qiang",
                "org": ""
            },
            {
                "name": "JIN Ji-fen",
                "org": ""
            }
        ],
        "venue": "Seed",
        "year": 2008
    },
    "Y1Q2EDfl": {
        "id": "Y1Q2EDfl",
        "title": "The Effect of Seed Soaking with Aluminum on Seed Germination of Hylocereus polyrhizus(Weber) Britt.& Rose",
        "abstract": "The study deals with the effect of aluminum on germination of Hylocereus polyrhizus(Weber) Britt.& Rose seed with different concentrations of aluminum solution(0\u30010.1\ue5f2mg/L\u30011\ue5f2mg/L\u300110\ue5f2mg/L\u3001100\ue5f2mg/L\u3001(1\ue5f2000\ue5f2mg/L)\u30012\ue5f2000\ue5f2mg/L)to soaking seed.The results showed:different densities of aluminum treatment all had physiology activity.They have effected the seeds germination energy,germination percentage,germination index,the fresh weight of seedling and vigor index.Among the seven aluminum treatment,0.1 mg/L aluminum solution treatment had the best effects on Hylocereus polyrhizus(Weber) Britt.& Rose seeds.The seedlings growth were poisoned by high concentration((2\ue5f2000\ue5f2mg/L)) of aluminum treatment.",
        "keywords": [
            "Aluminum Hylocereus polyrhizus(Weber) Britt.& Rose Seed germination"
        ],
        "authors": [
            {
                "name": "Wang Bin",
                "org": "Guizhou Citrus Research Institute of Sciences,Luodian,"
            },
            {
                "name": "Zheng Wei",
                "org": "Guizhou Citrus Research Institute of Sciences,Luodian,"
            },
            {
                "name": "Li xingzhong",
                "org": "Guizhou Citrus Research Institute of Sciences,Luodian,"
            }
        ],
        "venue": "Seed",
        "year": 2006
    },
    "9mh1hhcJ": {
        "id": "9mh1hhcJ",
        "title": "Effects of 1-Methylcyclopropene Fumigation Treatment on Physiological Characteristics of Pitaya Fruits during Storage Period",
        "abstract": "The fruits of Jinghonglong,a new pitaya variety with white flesh,were fumigated with 1-MCP to study the effects on fruit hardness,respiration intensity,POD and CAT activity,PG and PE enzymatic activity,content of soluble pectin and insoluble pectin and discuss the anti-aging mechanism of 1-MCP in fresh preservation of pitaya during the storage period.The results showed that 1-MCP fumigation treatment delayed reduction of fruit hardness at the late storage period and inhibited the respiratory intensity of pitaya fruits to some extent.The 1-MCP fumigation treatment delayed the senescence process of pitaya fruits during the earlier storage period,but it accelerated the senescence process of pitaya fruits during the late storage period.",
        "keywords": [
            "Cold storage",
            "Post-harvest physiology",
            "Fresh preservation",
            "1-Methycylopropene(1-MCP)",
            "Pitaya"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "HE Xu-xiao",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "LI Sheng-hai",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "DENG Ren-ju",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHOU Jun-liang",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2011
    },
    "ZCo4UmHs": {
        "id": "ZCo4UmHs",
        "title": "Research progress on occurrence and development characteristics, comprehensive control techniques of peach fruit borer",
        "abstract": "Peach fruit borer,Carposina sasakii Matsumura,is one of the most damaging pests in fruit orchard in China,research progress on occurrence and development characteristics,comprehensive control techniques of peach fruit borer were systematically introduced in this paper,in order to seek further research direction as well as to explore new ways to control peach fruit borer.",
        "keywords": [
            "Habits",
            "Peach fruit borer",
            "Control"
        ],
        "authors": [
            {
                "name": "YANG Hua",
                "org": ""
            },
            {
                "name": "PENG Yu-ji",
                "org": ""
            },
            {
                "name": "HAN Xiu-mei",
                "org": ""
            },
            {
                "name": "ZHENG Wei",
                "org": ""
            },
            {
                "name": "WU Ya-wei",
                "org": ""
            }
        ],
        "venue": "Chinese Horticulture Abstracts",
        "year": 2012
    },
    "JQ8pfUyn": {
        "id": "JQ8pfUyn",
        "title": "Analysis on Nutritional Quality of Loquats from Different Producing Areas in Guizhou",
        "abstract": "In order to evaluate the nutritional quality of different loquat cultivars,screening out the nutrient-rich ones to meet different needs and to provide references for loquat quality breeding,the nutritional quality of six loquats from Kaiyang County and Luodian County was determined and analyzed.The results show that the contents of reducing sugar,total sugar,total acidity and vitamin C are obviously different in various loquat cultivars,ranging between 7.51%\uff5e15.62%,7.65%\uff5e16.37%,0.268%\uff5e1.608% and 4.61%\uff5e28.16% respectively.The Baiyu cultivar has the best comprehensive nutritional quality,while the Changbai cultivar has the worst nutritional quality.",
        "keywords": [
            "loquat",
            "varieties",
            "Guizhou",
            "nutritional quality",
            "producing area"
        ],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "LI Xing-zhong",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2012
    },
    "hRoFd8MU": {
        "id": "hRoFd8MU",
        "title": "RAPD Analysis of Early Maturing Germplasm Resources of Loquat(Eriobotrya japonica Lindl.)",
        "abstract": "In this study,16 local Early-ripe resources and 3 induced cultivars in loquat was researched.6 primers are selected from 60 random primers and can be successfully used for amplifying the DNA of 19 loquat cultivars and showing polymorphism.85 bands are obtained,among which 67 bands show polymorphism,amounting to 78.82%.Genetic distances and cluster analysis are also performed for the cultivars.",
        "keywords": [
            "Genetic diversity analysis",
            "Early-riping resources",
            "RAPD",
            "Loquat"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "FAN Jian-xin",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "LI Xing-zhong",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "DENG Ren-ju",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2012
    },
    "BqJaMGS2": {
        "id": "BqJaMGS2",
        "title": "Study on Germination Characteristics of Pitaya Seeds",
        "abstract": "Seeds of three Pitaya strains Hylocereus polyrhizus (Weber) Britt.& Rose,Hylocereus spp.and Hylocereus undatus Britt.& Rose were used as the experimental materials to study the germination characteristics of Pitaya seeds.The results indicated that different genotype Pitaya strain seeds had different germination rate.The germination rate of Hylocereus undatus Britt.& Rose was 93.3%,the highest among three Pitaya strain,but the seedlings did not come out evenly,and the germination energy only 16.0%.The difference of germination energy which is between the highest and the lowest germination of the different genotype Pitaya strain seeds is 57.3%,and the difference of germination index between the highest and the lowest is 45.79%.The result also improved that the seeds vigor of the Hylocereus spp.was the strongest,the Hylocereus polyrhizus(Weber) Britt.& Rose took the second place,but the Hylocereus undatus Britt.& Rose was the infirmest.",
        "keywords": [
            "germination characteristics",
            "pitaya",
            "seed"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "College of Horticulture and Landscape,Hunan Agricultural University,Changsha ,China;Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Citrus Institute,Luodian ,China;College of Bio-Safety Science and Technology,Hunan Agricultural University,Changsha ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "JIN Jifen",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "LI Xing-zhong",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "XIE Shen-xi",
                "org": "College of Horticulture and Landscape,Hunan Agricultural University,Changsha ,China"
            }
        ],
        "venue": "Seed",
        "year": 2007
    },
    "qqHUYU6H": {
        "id": "qqHUYU6H",
        "title": "Selection of Pollination Varieties in Pitaya",
        "abstract": "The pollination comparative test between Qianlong 2,Qianlong 1 and Pink flesh varieties was conducted to select good pollinated Pitaya varieties.The results show that Qianlong 2 and Pink flesh varieties are of the higher percentage of fertile fruit by self-pollination and quality fruits,and Qianlong 2 and Pink flesh varieties can be selected as good pollination varieties for Qianlong 1.",
        "keywords": [
            "quality",
            "Pitaya",
            "pollination",
            "percentage of fertile fruit"
        ],
        "authors": [
            {
                "name": "JIN Jifen",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            },
            {
                "name": "CAI Yongqiang",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            },
            {
                "name": "ZHANG Jianxin",
                "org": "Guizhou Development Center for Green Foods,Guiyang,Guizhou ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            },
            {
                "name": "CHEN Jialong",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou "
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2008
    },
    "7MgiI8eL": {
        "id": "7MgiI8eL",
        "title": "The Variation Trend of Fruit Fresh Weight,Flesh Water Demand and Distribution of Qianlong 1(a Pitaya Variety)",
        "abstract": "The variation trend of whole fruit,flesh,peel and scale fresh weight and flesh water demand and distribution of Qianlong 1(a pitaya variety) were studied to discuss its fruit development process.The results showed that the increase of fruit fresh weight presents a double \"S\" type throughout the growing period,the whole fruit and flesh fresh weight is up to maximum at fruit maturity stage,water supports increase of fruit and flesh weight,the fruit water content and its water increase rate is up to the maximum at later period of fruit period,the maximum period of water efficiency is at 24\uff5e29d after its flowering and the proportion of water and dry matter in flesh is the highest at fruit maturity stage,followed by peel and scale.",
        "keywords": [
            "water",
            "pitaya",
            "qianlong1",
            "fruit",
            "fresh weight",
            "water content"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2009
    },
    "uOb1gtHh": {
        "id": "uOb1gtHh",
        "title": "Change of Fruit Shape,Dry Weight and Solute Distribution of Qianlong 1(a Pitaya Variety) during Fruit Development",
        "abstract": "The results showed that the growth curve of vertical and horizontal diameter of fruit exshibited double \"S\" ,its fruit shape was nearly round,its dry weight increased gradually as the development of fruit and still increased in mature stage; the fruit solute was mainly supplied for the growth of peel and scale in the early fruit development stage and for the rapid growth of flesh in the later fruit development stage,the solute accumulation in flesh reached its maximum value when fruits were close to mature; and the solute transportation rate still maintained high when fruits were mature.",
        "keywords": [
            "pitaya",
            "fruit",
            "fruit shape",
            "Qianlong 1",
            "solute",
            "dry weight"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2010
    },
    "2X27W9r6": {
        "id": "2X27W9r6",
        "title": "STUDY ON THE EXTRACTION TECHNOLOGY OF FROM SESAME CAKE FERMENTATION",
        "abstract": "Sesame cake was fermented with Aspergillus sojae 2128.The ferment condition and the antioxidative activity of crude extraction were studied.The result showed that the antioxidative activity advance observably,the optimum inoculate volume is 3 mL,time 4 d,methanol concentration is 70 %(v/v), eliminate ratio 95.21 %.",
        "keywords": [
            "DPPH",
            "Aspergillus sojae 2128",
            "antioxidative",
            "sesame cake"
        ],
        "authors": [
            {
                "name": "DONG Ying",
                "org": "School of Food and Biological Engineering ,Jiangsu University,Zhenjiang ,Jiangsu,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "School of Food and Biological Engineering ,Jiangsu University,Zhenjiang ,Jiangsu,China"
            }
        ],
        "venue": "Food Research and Development",
        "year": 2007
    },
    "AxAzDums": {
        "id": "AxAzDums",
        "title": "Research Progress on Main Diseases and Insect Pests of Pitaya",
        "abstract": "This paper summarizes the research progress on disease and pests of Pitaya in China,emphatically elaborates the symptom,occurrence regulation and control methods,and preliminarily discusses the comprehensive technique for controlling disease and pests of Pitaya in the future.",
        "keywords": [
            "control",
            "insect pest",
            "Pitaya",
            "diseases"
        ],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": "College of Bio-Safety Science and Technology,Hunan Agricultural University,Changsha,Hunan ;Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "CAI Yongqiang",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "DAI Liangying",
                "org": "College of Bio-Safety Science and Technology,Hunan Agricultural University,Changsha,Hunan "
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2007
    },
    "d4ip3o67": {
        "id": "d4ip3o67",
        "title": "Effects of Different Storage Temperature on Postharvest Physiology and Quality of Pitaya",
        "abstract": "In order to study effects of different storage temperature on postharvest physiology and quality of pitaya and explore the optimal storage temperature,meanwhile,to provide further theoretical guide for the development and application of pitaya storage technique.Respiration intensity,weight-loss ratio,rotten rate, soluble solid,reducing sugar,titratable acid and ascorbic acid of pitaya during the storage at room temperature and(10\u00b10.5) \u2103were studied.The results showed that compared with room temperature,storage temperature at (10\u00b10.5) \u2103 could significantly reduce the respiration intensity,suppress rapid weight loss,decay,and soluble solids of pitaya,reduce sugar increasing,slow the decreasing of titratable acid and ascorbic acid during the whole storage period.",
        "keywords": [
            "Quality",
            "Postharvest physiology",
            "Storage temperature",
            "Pitaya"
        ],
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "LI Sheng-hai",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "HE Xu-xiao",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "DENG Ren-ju",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            },
            {
                "name": "ZHOU Jun-liang",
                "org": "Guizhou Fruit Institute,Guizhou Guiyang ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2012
    },
    "48RhOt6M": {
        "id": "48RhOt6M",
        "title": "Effects of Different Cultivation Substrates on Seedling Rate and Growth of Pitaya",
        "abstract": "Two kinds of cultivation substrates(the substrate with the upper river sand + lower nutrient soil and the river sand substrate) were tested to investigate effects of different substrates on seedling rate and seedling growth of three Pitaya varieties.The results show that the seedling time and average seedling rate of Pitaya seeds cultivated on the substrate with the upper river sand + lower nutrient soil are 8 d early and 25.6%\uff5e40.4% higher than those cultivated on the river sand substrate respectively,the average seedling rate of three tested varieties is Hylocereus undatus Britt.& Rose>Hylocereus polyrhizus(Weber) Britt.& Rose> Hylocereus undatus and the growth vigor of young seedlings cultivated on the substrate with the upper river sand + lower nutrient soil is better than that cultivated on the river sand substrate.",
        "keywords": [
            "germination rate",
            "pitaya",
            "cultivation substrate",
            "growth of young seedling"
        ],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "PENG Yu-ji",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            },
            {
                "name": "LI Xing-zhong",
                "org": "Guizhou Citrus Institute,Luodian ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2006
    },
    "YQOUEjAt": {
        "id": "YQOUEjAt",
        "title": "Effects of Different Nutrition Soil on Seedling Quality of Smallanthus Sonchifolius",
        "abstract": "Three common formula nutrition soils were tested in raising Smallanthus Sonchifolius seedlings to study the effects on plant height,stem diameter,root length,maximum leaf area,fresh weight and dry weight at its seedling stage and to calculate the index of sound seedlings for selecting the optimum substrate.The results showed that the optimum substrate for raising Smallanthus Sonchifolius seedlings was river sand 1\u2236 vegetable garden soil 1\u2236 humus 1 and the plant height,stem diameter,root length,maximum leaf area,fresh weight,dry weight sound seedling index and G value was 11.95 cm,0.85 cm,27.6 cm,77.66 cm2,42.35 g,3.62 g,0.257 and 0.0236 respectively under the optimum substrate.Therefore,the optimum substrate can be used in raising Smallanthus Sonchifolius seedlings.",
        "keywords": [
            "nutrition soil",
            "Smallanthus Sonchifolius",
            "raising seedling",
            "sound seedling"
        ],
        "authors": [
            {
                "name": "JIN Ji-lin",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "JIN Ji-fen",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "LIU Tao",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            },
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Luodian,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2009
    },
    "HsulvOAm": {
        "id": "HsulvOAm",
        "title": "Effect of Different Growth Regulators on Cutting Seedlings of Different Pitaya Varieties",
        "abstract": "Different growth regulators with different concentrations were used in cuttings of Zihonglong pitaya variety based on comparison of the cutting rooting effect between four tested pitaya varieties to study the different cutting survival rate and effect of different plant regulators on cutting rooting of Zihonglong pitaya variety.The results showed that the cutting rooting effect of different tested varieties was Tianchi> Zihonglong >Fenhonglong,the tested growth regulators with different concentrations,except the rooting agent with 200mg/L,had the significant promotion effect on cutting rooting of Zihonglong pitaya variety.IBA with the best comprehensive effect is an ideal root-promoting agent for rapid propagation of pitaya.",
        "keywords": [
            "pitaya",
            "rooting rate",
            "growth regulator",
            "cutting",
            "variety"
        ],
        "authors": [
            {
                "name": "ZHENG Wei",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "WANG Bin",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "CAI Yong-qiang",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            },
            {
                "name": "LI Xing-zhong",
                "org": "Guizhou Fruit Institute,Guiyang,Guizhou ,China"
            }
        ],
        "venue": "Guizhou Agricultural Sciences",
        "year": 2010
    },
    "Y59UnJzt": {
        "authors": [
            {
                "name": "Xiao Liu",
                "org": "Henan Polytechnic University"
            }
        ],
        "title": "Measures to improve undergraduate graduation design in a coal and coalbed methane major",
        "abstract": "Undergraduate graduation design (a final year student project or thesis at Chinese universities) is an important part of undergraduate education. The quality of it has declined with the development of mass higher education in China. The characteristics of undergraduate graduation design in a coal and coalbed methane engineering major are summarised in this article, and the problems and deficiencies are identified and discussed. These include problems with graduation practice, topic selection for graduation design, research, mid-term supervision and thesis writing. Measures to improve graduation design are summarised and include improving the management of the graduation design and thesis quality.",
        "keywords": [
            ""
        ],
        "venue": "World Transactions on Engineering and Technology Education",
        "year": 2014,
        "id": "Y59UnJzt"
    },
    "FxcrGytP": {
        "id": "FxcrGytP",
        "title": "Terahertz wave manipulation through coupling of spoof plasmonics and Fabry\u2013Perot resonance",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Baoshan Guo",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, People\u2019s Republic of China"
            },
            {
                "name": "Lan Jiang",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, People\u2019s Republic of China"
            },
            {
                "name": "Yanhong Hua",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, People\u2019s Republic of China"
            },
            {
                "name": "Xin Li",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, People\u2019s Republic of China"
            },
            {
                "name": "Tianhong Cui",
                "org": "Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, 55455, United States of America"
            },
            {
                "name": "YongFeng Lu",
                "org": "Department of Electrical Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0511, United States of America"
            }
        ],
        "venue": "Journal of Physics D",
        "year": 2018
    },
    "KSnjqcyj": {
        "id": "KSnjqcyj",
        "title": "Polymorph-Controlled Crystallization of Acetaminophen through Femtosecond Laser Irradiation",
        "abstract": "Polymorph-controlled crystallization of acetaminophen was conducted through femtosecond laser double-pulse irradiation. Dependence of the crystal form of acetaminophen on the pulse energy and double-pulse delay has been established. By optimizing the pulse energy and double-pulse delay, the percentage of the Forms II and III of acetaminophen was considerably increased to more than 40%. Under optimal conditions, unstable Form III of acetaminophen was obtained with the crystal size of approximately 100 \u03bcm and the aspect ratio of 23. This is particularly crucial because this form of acetaminophen is difficult to obtain without the use of laser. Through real-time imaging of cavitation bubbles, we discovered that high concentrations were induced at the focal point. Moreover, solution-mediated polymorphic transformations from Form III to Form I and Form II to Form I were observed with an in situ charge coupled device camera.",
        "keywords": "",
        "authors": [
            {
                "name": "Shubo Wang",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Sumei Wang",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Lan Jiang",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Mengmeng Wang",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Yuyin Wei",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Jiaxin Sun",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Shenghua Zhan",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Xin Li",
                "org": "Laser Micro/Nano Fabrication Laboratory, School of Mechanical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            },
            {
                "name": "Liangti Qu",
                "org": "School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China"
            }
        ],
        "venue": "Crystal Growth & Design",
        "year": 2019
    },
    "D1o28oIl": {
        "id": "D1o28oIl",
        "title": "MBD2 ablation impairs lymphopoiesis and impedes progression and maintenance of T-ALL.",
        "abstract": "Aberrant DNA methylation patterns in leukemia might be exploited for therapeutic targeting. In this study, we employed a genetically deficient mouse model to explore the role of the methylated DNA binding protein MBD2 in normal and malignant hematopoiesis. MBD2 ablation led to diminished lymphocytes. Functional defects of the lymphoid compartment were also observed after in vivo reconstitution of MBD2-deficient hematopoietic stem cells (HSC). In an established model of Notch1-driven T cell acute lymphoblastic leukemia (T-ALL), MBD2 ablation impeded malignant progression and maintenance by attenuating the Wnt signaling pathway. In clinical specimens of human T-ALL, Wnt signaling pathway signatures were significantly enhanced and positively correlated with the expression and function of MBD2. Further, a number of typical Wnt signaling inhibitory genes were abnormally hypermethylated in primary human T-ALL. Abnormal activation of Wnt signaling in T-ALL was switched off by MBD2 deletion, partially by reactivating epigenetically silenced Wnt signaling inhibitors. Taken together, our results define essential roles for MBD2 in lymphopoiesis and T-ALL and suggest MBD2 as a candidate therapeutic target in T-ALL.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhou Mi",
                "org": "Department of hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Zhou Kuangguo",
                "org": "Hematology, Huazhong University of Science &amp; Technology."
            },
            {
                "name": "Cheng Ling",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China."
            },
            {
                "name": "Chen Xing",
                "org": "Department of hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Wang Jue",
                "org": "Department of hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Wang Xiao-Min",
                "org": "State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences."
            },
            {
                "name": "Zhang Yingchi",
                "org": "State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College."
            },
            {
                "name": "Yu Qilin",
                "org": "The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Zhang Shu",
                "org": "The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Wang Di",
                "org": "Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Huang Liang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science &amp; Technology."
            },
            {
                "name": "Huang Mei",
                "org": "Hematology, Huazhong University of Science &amp; Technology."
            },
            {
                "name": "Ma Ding",
                "org": "Cancer Biology Research Center (Key laboratory of the ministry of education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Cheng Tao",
                "org": "State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital."
            },
            {
                "name": "Wang Cong-Yi",
                "org": "The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology."
            },
            {
                "name": "Yuan Weiping",
                "org": "State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College."
            },
            {
                "name": "Zhou Jianfeng",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; jfzhou@tjh.tjmu.edu.cn."
            }
        ],
        "venue": "Cancer research",
        "year": 2018
    },
    "OTj0EITa": {
        "id": "OTj0EITa",
        "title": "Analysis of IKAROS6 expression in 73 patients with chronic myelogenous leukemia]",
        "abstract": "This study was aimed to evaluate IKAROS6 expression in patients with chronic myelogenous leukemia (CML) and its clinical significance. cDNAs from 73 CML patients were amplified by PCR and sequenced for IKAROS expression to elucidate clinical characteristics in IKAROS6 positive patients. The results showed that there was no IKAROS6 gene expression in 8 healthy controls and 15 CML patients in chronic phase and accelerated phase, and 15 cases (35.71%) were IKAROS6 positive in lymphoblast crisis samples among 42 newly diagnosed CML; however, none was found in myeloblast crisis of 16 newly diagnosed CML. Among 42 lymphoblast crisis of CML, the complete remission (CR) rate of IKAROS6 expression positive patients reached 40% (6/15), which was obviously lower than that in IKAROS6 negative patients (85.19%, 23/27) (p < 0.01), IKAROS6 positive patients relapsed after CR for 15 (2 - 18) months with relapse rate 66.7% (4/6), which was higher than that in expressed wild type IKAROS gene patients (21.74%, 5/23) (p < 0.05). It is concluded that abnormal expression of IKAROS gene dominated by IKAROS6 isoforms can be detected in lymphoblast crisis samples of CML patients. Abnormal expression of IKAROS gene may be an important factor in lymphoblast crisis of CML. Therefore, detection of IKAROS gene expression may be important for target therapy and evaluation of clinical prognosis of CML patients.",
        "keywords": [
            "acute lymphoblastic leukemia",
            "ikaros6 gene",
            "chronic myelogenous leukemia"
        ],
        "authors": [
            {
                "name": "XIAO Min",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WU Ying",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "YANG Yang",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "SHANG Zhen",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "HONG Zhen-Ya",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WANG Di",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "ZHOU Jian-Feng",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "LI Chun-Rui",
                "org": " Department of Hematology,Tongji Hospital,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            }
        ],
        "venue": "Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology",
        "year": 2011
    },
    "tVlcfjox": {
        "id": "tVlcfjox",
        "title": "Detection of Invasive Aspergillosis by Serum Galactomannan Test:A Systematic Review",
        "abstract": "Objective To assess the quality of current domestic literature about enzyme-linked immunosorbent as-say(ELISA) for invasive aspergillosis diagnosis by detecting Aspergillus galactomannan(GM) antigen,and to analyze the sources of bias and variability,as well as the diagnostic ability of different thresholds.Methods Both computer-based online search and manual retrieval were employed to identify relevant articles.Theffstatistical information and quality of science were assessed and classi ed.The data were analyzed using Meta Disc 1.4 so ware.The best cuto value for defining a positive test result was selected by summarizing the following statistical indicators as sensitivity,specificity,likeli-hood ratio(LR) and summary receiver operating characteristic curve(SROC curve),and by calculating the area under the curve(AUC) as well.Results A total of 20 studies among 2658 literatures were included in accordance with the inclu-sion criteria,and were divided into different groups based on different cuto values.ough heterogeneity tests showed no threshold effect,and there were other reasons of heterogeneity.So the data were analyzed by random e ects model.The results showed that,compared with other groups,the one with cuto value set at 0.7(AUC=0.9456,Q*= 0.8846) showed the best accuracy in diagnosing.Conclusion ELISA detection of Aspergillus GM antigen with cuto value set at 0.7 has important significance in the early diagnosis of invasive aspergillosis,and it can be conducive to reduce mortality in patients at high risk for Aspergillus infection.",
        "keywords": [
            "Galactomannan",
            "Cutoff value",
            "Invasive aspergillosis",
            "Systematic review",
            "Diagnostic test"
        ],
        "authors": [
            {
                "name": "GENG Zhe",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            },
            {
                "name": "YE Cong",
                "org": "Department of Rheumatology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            },
            {
                "name": "XIAO Yi",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            },
            {
                "name": "WANG Di",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            },
            {
                "name": "HUANG Liang",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            },
            {
                "name": "LI Chun-rui",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            },
            {
                "name": "ZHOU Jian-feng",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,WuHan ,China"
            }
        ],
        "venue": "Chinese Journal of Evidence-Based Medicine",
        "year": 2011
    },
    "kto1KxPI": {
        "id": "kto1KxPI",
        "title": "RGD-modified rAAV2 Mutant Vectors Enhance Gene Transduction in Ovarian Cancer Cell Lines",
        "abstract": "Objective To further investigate the specific gene transduction mediated by RGD-rAAV2 mutant vector in ovarian cancer cell lines.Methods The expression of HSPG and the integrin \u03b1_v\u03b2_3 and \u03b1_v\u03b2_5 was detected by using FACS on 6 human ovarian cancer cell lines(PA-1,OV-3,OV-4,OVCAR-3,SKOV-3ip and Hey).The gene transduction efficiencies mediated by wild type rAAV2 in different ovarian cancer cell lines were evaluated by FACS.Ligands competitive binding experiment was used to assess whether RGD-rAAV2 was able to mediate successfully gene transduction in wt-rAAV2 resistant cell line SKOV-3ip.Results Wild type rAAV2 variably transduced the different ovarian cancer cell lines.HSPG expression varied considerably among the six tested ovarian cancer cell lines,and 80 % of cell lines expressed moderate integrin \u03b1_v\u03b2_3 and \u03b1_v\u03b2_5.RGD-rAAV2 exerted more effective infection and higher gene transduction in SKOV-3ip than wt-rAAV2.Conclusion Integrin-retargeted RGD-rAAV2 showed higher efficacy in gene transduction which was in-dependent of HSPG,which provided its application feasibility in ovarian cancer gene therapy in vivo.",
        "keywords": [
            "Arg-Gly-Asp",
            "ovarian carcinoma",
            "adeno-associated virus",
            "gene transduction"
        ],
        "authors": [
            {
                "name": "Fang Guangguang",
                "org": "Department of Obstetrics and Gynecology,Shenzhen Second Peoples' Hospital,Shenzhen ~"
            },
            {
                "name": "Wang Di",
                "org": "Department of Immunology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ~"
            },
            {
                "name": "Tang Liangzhen",
                "org": "Department of General Surgery,Wuhan Second Hospital,Wuhan "
            }
        ],
        "venue": "Acta Medicinae Universitatis Scientiae et Technologiae Huazhong",
        "year": 2006
    },
    "H20A5zTI": {
        "id": "H20A5zTI",
        "title": "Combination of cytogenetic analysis and molecular screening in patients with de novo acute myeloid leukemia.",
        "abstract": "Nowadays the role of genetic findings in determining the diagnosis, therapy and prognosis of acute myeloid leukemia (AML) has become more valuable. To improve and validate the detection of clonal chromosomal aberrations in leukemia, we designed a combined application of karyotyping with multiplex reverse transcription-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH), and addressed the expression and distribution of fusion genes among the subtypes of Chinese adult patients with de novo AML. Multiplex RT-PCR assays were performed on 477 samples from newly diagnosed AML patients, and cytogenetic data were obtained from 373 of them by R or G banding techniques and those in some cases were confirmed by FISH. The PCR products in some suspected cases were tested by two-directional sequencing. The results showed that except unqualified samples, fusion genes were detected by multiplex RT-PCR in 211 of 474 patients (44.51%), including AML1-ETO, CBF\u03b2-MYH11, PML-RAR\u03b1, PLZF-RAR\u03b1, NPM-RAR\u03b1, MLL rearrangements, BCR-ABL, DEK-CAN, SET-CAN, TEL-PDGFR, TLS-ERG, AML1-MDS1 (EVI-1). In 373 patients, who took both multiplex RT-PCR and karyotype analysis, the detection rate of chromosomal aberrations by using multiplex RT-PCR and karyotyping was 160/373 (42.89%) and 179/373 (47.98%) respectively, and the combination could optimize the detection rate of clonal genetic abnormalities to 216/373 (57.90%). The PCR results from 11 cases \"normal\" in karyotyping but abnormal in RT-PCR for MLL rearrangements were confirmed by two-directional sequencing. It is concluded that karyotype studies remain the cornerstone for genetic testing; conventional cytogenetics and molecular-based methods are complementary tests for the detection of clonal genetic aberrations in AML, especially for the cryptic or submicroscopic aberrations. Once a genetic marker has been identified by combined analysis, it could be used to monitor residual disease during/after chemotherapy, by quantitative RT-PCR and/or FISH.",
        "keywords": [
            "acute myeloid leukemia",
            "chromosome aberration",
            "fluorescence in situ hybridization",
            "multiplex reverse transcription-polymerase chain reaction",
            "karyotyping"
        ],
        "authors": [
            {
                "name": "Zhe GENG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Heng ZHANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Di WANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Yi XIAO",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Na WANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Chunrui LI",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Liang HUANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Jianfeng ZHOU",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            }
        ],
        "venue": "Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban",
        "year": 2012
    },
    "ljoUmv1Z": {
        "id": "ljoUmv1Z",
        "title": "Mutation of isocitrate dehydrogenase 2 (IDH2) gene in Chinese AML patients and its clinical significance]",
        "abstract": "This study was purpose to analyze the frequency and of isocitrate dehydrogenase 2 (IDH2) gene mutation in acute myeloid leukemia (AML) and its clinic significance. The multiplex polymerase chain reaction (PCR) and sequencing were performed to screen 192 AML patients for exon 4 of the IDH2 gene. FLT3, NPM1, CEBPA, c-kit and WT1 mutations were also included in analysis. The results showed that IDH2 mutation was found in 14 (7.29%) of 192 patients. There were 9 AML patients with R140Q mutation, 1 patient with R140W mutation, and 1 patient with R172K mutation. IDH2 aberrations significantly more were detected in French-American-British (FAB) M5 (P < 0.005) than other types. There was no statistical difference in age, sex, WBC, platelet count, bone marrow blasts count, hemoglobin as compared with IDH2 wild-type. For immunotype analysis, IDH2 mutation patients were more likely to express CD34 and CD13, less CD36. IDH2 mutation combined with FLT3/ITD mutation was found in 7 cases, with CEBPA mutation in 4 cases, with NPM1 mutation in 4 cases, with Dnmt3a mutation in 5 cases, neither with c-kit, IDH1 or WT1 mutation for no one, which revealed a significant interaction between IDH2 mutation and the FLT3/ITD positive genotype, Dnmt3a mutated, and IDH1 wild-type. IDH2 mutation was detected in 5 (8.47%) of 59 CN-AML. There was no significant difference of IDH2 mutation incidence between the normal and abnormal karyotype. The CR rate was higher in IDH2 R140 mutated patients than wild-type ones, but there was no significant in the two group. It is concluded that the rate of IDH2 mutation is 7.29% in Chinese AML patients and 7.81% in CN-AML. IDH2 mutation is significantly associated with AML-M5, FLT3/ITD, Dnmt3a, IDH1 wild-type and fusion gene wild-type, but not with age, leucocyte and platelet counts in peripheral blood, karyotype, NPM1, CEBPA, c-kit or WT1 mutation. And IDH2 R140 mutation has no impact on CR rate.",
        "keywords": [
            "isocitrate dehydrogenase 2",
            "mutation",
            "acute myeloid leukemia"
        ],
        "authors": [
            {
                "name": "SHANG Zhen",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WANG Di",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "XIAO Min",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WANG Jue",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "LI Tong-Juan",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "ZHAO Yue-Chao",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "LI Chun-Rui",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "ZHOU Jian-Feng",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            }
        ],
        "venue": "Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology",
        "year": 2013
    },
    "hJuh3LTD": {
        "id": "hJuh3LTD",
        "title": "Anti-BCMA CAR-T cells for treatment of plasma cell dyscrasia: case report on POEMS syndrome and multiple myeloma.",
        "abstract": "ChiCTR-OPC, ChiCTR-OPC-16009113 . Registered 29 August 2016.",
        "keywords": [
            "B cell maturation antigen",
            "Chimeric antigen receptor T cells",
            "Multiple myeloma",
            "POEMS syndrome",
            "Remissions"
        ],
        "authors": [
            {
                "name": "Jinhuan Xu",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Qiuxiang Wang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Hao Xu",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Chaojiang Gu",
                "org": "College of Life Science and Health, Wuhan University of Science and Technology, Wuhan, 430065, Hubei, People's Republic of China."
            },
            {
                "name": "Lijun Jiang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Jue Wang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Di Wang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Bin Xu",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Xia Mao",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Jin Wang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Zhiqiong Wang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Yi Xiao",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Yicheng Zhang",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China."
            },
            {
                "name": "Chunrui Li",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China. cunrui5650@hust.edu.cn."
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Immunotherapy Research Center for Hematologic Diseases of Hubei Province, 1095 Jie-Fang Avenue, Wuhan, 430030, Hubei, People's Republic of China. jfzhou@tjh.tjmu.edu.cn."
            }
        ],
        "venue": "Journal of hematology & oncology",
        "year": 2018
    },
    "0INZRI6O": {
        "id": "0INZRI6O",
        "title": "Investigation of minerals and vitamin\u2032 s intake levels among 475 college students in Wuhan",
        "abstract": "Objective To investigate the intake levels of minerals and vitamin among college students in Wuhan and to provide a scientific basis for health education among college students and management of canteen meals.Methods The survey was conducted among 475 college students by food diary and 24 h recall methods for 3 d.And 400 questionnaires were available.Results Intakes of calcium,iron,zinc,vitamin B1,vitamin B2,nicotinic acid and vitamin C did not reach recommended nutrient intake(RNI) or appropriate intakes(AI) except vitamin A intake of female students.The ratios of calcium,iron,zinc,vitamin A from plant foods were high.Conclusion The dietary intake levels of minerals and vitamin among students are obviously low,which should arouse the emphasis of the related departments for taking the comprehensive measures to launch the multiform propaganda and education of nutritional knowledge and nutrition intervention.",
        "keywords": [
            "college student",
            "vitamins",
            "minerals"
        ],
        "authors": [
            {
                "name": "Zhao Haiyue",
                "org": "School of Second Clinical Medicine"
            },
            {
                "name": "Zhu Leilei",
                "org": "School of Second Clinical Medicine"
            },
            {
                "name": "Wang Di",
                "org": "College of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei ,China"
            }
        ],
        "venue": "Chongqing Medicine",
        "year": 2012
    },
    "nv6uH3DO": {
        "id": "nv6uH3DO",
        "title": "Integrative analysis of prognostic factors in Chinese core binding factor leukemia.",
        "abstract": "The characteristics of core binding factor (CBF) leukemia appear to differ between Chinese and Caucasian patients. In this study, we analyzed the biological and clinical characteristics of 76 Chinese CBF leukemia patients out of 425 newly diagnosed acute myeloid leukemia (AML) patients. The frequency of CBF AML was 17.9%. Patients harboring t(8;21) were predominant in CBF AML. The incidence of c-kit mutation in CBF AML was 28.9%. The N822K mutation appeared to be more prevalent in Chinese CBF AML patients. Multivariate analysis showed that c-kit mutation and high white blood cell count could negatively impact overall survival (OS) (HR=2.74 and 6.24, P=0.007 and 0.022, respectively) but did not affect relapse-free survival (RFS). Kaplan-Meier analysis showed a significant difference in both OS and RFS between wild-type and mutated c-kit patients. Although we had included recently reported prognostic indicators in our analysis, our results demonstrated that only c-kit mutation and high white blood cell count had prognostic impact on Chinese CBF AML patients.",
        "keywords": [
            "mutation"
        ],
        "authors": [
            {
                "name": "Wang Di",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China."
            },
            {
                "name": "Qiao Chun",
                "org": ""
            },
            {
                "name": "Xiao Min",
                "org": ""
            },
            {
                "name": "Geng Zhe",
                "org": ""
            },
            {
                "name": "Shang Zhen",
                "org": ""
            },
            {
                "name": "He Jing",
                "org": ""
            },
            {
                "name": "Huang Mei",
                "org": ""
            },
            {
                "name": "Yang Yang",
                "org": ""
            },
            {
                "name": "Zhang Na",
                "org": ""
            },
            {
                "name": "Liu Yanan",
                "org": ""
            },
            {
                "name": "Li Jianyong",
                "org": ""
            },
            {
                "name": "Li Chunrui",
                "org": ""
            },
            {
                "name": "Zhou Jianfeng",
                "org": ""
            }
        ],
        "venue": "Biochemical and biophysical research communications",
        "year": 2012
    },
    "vdmLtiWS": {
        "id": "vdmLtiWS",
        "title": "Establishment of xenotransplantation model of human CN-AML with FLT3-ITD (mut) /NPM1 (-) in NOD/SCID mice.",
        "abstract": "Patients with FLT3-ITD (mut) /NPM1 (-) cytogenetically normal acute myeloid leukemia (CN-AML), as high-risk molecular group in CN-AML, are associated with a worse prognosis than other CN-AML patients. It is beneficial to generate xenotransplantation model of FLT3-ITD (mut) /NPM1 (-) CN-AML to better understand the pathogenesis and therapeutic strategies of such AML subtype. The purpose of present study was to establish the xenotransplantation model in NOD/SCID mice with FLT3-ITD (mut) /NPM1 (-) CN-AML primary cells. The FLT3-ITD (mut) /NPM1 (-) CN-AML primary cells from 3 of 7 cases were successfully transplanted into NOD/SCID mice, and human CD45 positive cells were detected in the peripheral blood, spleen and bone marrow of mice by using flow cytometry. Infiltration of human leukemia cells in various organs of mice was observed by using immunohistochemistry. Gene analysis confirmed sustained FLT3/ITD mutation without NPM1 mutation in mice. By performing serial transplantation, it was found that characteristics of the leukemia cells in secondary and tertiary generation models remained unchanged. Moreover, in vivo cytarabine administration could extend survival of NOD/SCID mice, which was consistent with clinical observation. In conclusion, we successfully established xenotransplantation model of human FLT3-ITD (mut) /NPM1 (-) CN-AML in NOD/SCID mice. The model was able to present primary disease and suitable to evaluate the curative effects of new drugs or therapy strategies.",
        "keywords": [
            "nod/scid mice",
            "acute myeloid leukemia",
            "xenotransplantation model",
            "npm1 mutation",
            "flt3/itd mutation"
        ],
        "authors": [
            {
                "name": "Zhen SHANG",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Jue WANG",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Di WANG",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Min XIAO",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Tong-juan LI",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Na WANG",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Liang HUANG",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            },
            {
                "name": "Jian-feng ZHOU",
                "org": " Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan , China"
            }
        ],
        "venue": "Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban",
        "year": 2013
    },
    "68qaqITc": {
        "id": "68qaqITc",
        "title": "Detection of isocitrate dehydrogenase 1 gene mutation in 205 AML patients and its clinical significance]",
        "abstract": "This study was purposed to detect the mutation of isocitrate dehydrogenase 1 (IDH-1) gene in patients with acute myeloid leukemia (AML) and to explore its clinical significance. The genomic DNA was extracted from mononuclear cells (MNC) of bone marrow or peripheral blood in 205 adult AML patients, the exon 4 of IDH1 gene was amplified by PCR, then the sequencing and comparison were performed. The results showed that IDH1 mutation was detected in 9 (4.39%) of 205 AML patients. There were 6 cases of R132H mutation, 1 of R132L mutation, 1 of R132G mutation and 1 of R132S mutation. Significantly more IDH1 aberrations were detected in AML-M2 (P = 0.002) than other types. And the 9 patients with IDH1 mutation were characterized by low platelet count which was lower than patients with wild type IDH1 (P = 0.003). IDH1 mutation combined with FLT3/ITD mutation was found in 5 cases, c-kit mutation in 1, NPM1 mutation in 2, and IDH1 mutation with CEBPA or WT1 mutation was not found, which revealed a significant interaction between IDH1 mutation and the FLT3/ITD positive genotype or the CEBPA wild-type. IDH1 mutation were detected in 4 of 71 (5.63%) CN-AML. There was no significant difference of IDH1 mutation incidence between the normal and abnormal karyotypes. It is concluded that the rate of IDH1 mutation was 4.39% in Chinese AML patients. IDH1 mutation is significantly associated with AML-M2, lower platelet counts in peripheral blood, FLT3/ITD mutation and CEBPA wild-type, but not with age, white blood cell count in peripheral blood, karyotype, NPM1, c-kit or WT1 mutation.",
        "keywords": [
            "gene mutation",
            "idh1 gene",
            "acute myeloid leukemia"
        ],
        "authors": [
            {
                "name": "SHANG Zhen",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WANG Di",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "XIAO Min",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "GENG Zhe",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WANG Hai-Xia",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "WANG Jue",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "XU Yan-Ling",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "LI Tong-Juan",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "ZHOU Jian-Feng",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            },
            {
                "name": "LI Chun-Rui",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei Province,China"
            }
        ],
        "venue": "Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology",
        "year": 2012
    },
    "8kAs83zm": {
        "id": "8kAs83zm",
        "title": "AC220 and AraC cause differential inhibitory dynamics in patient-derived M5-AML with FLT3-ITD and, thus, ultimately distinct therapeutic outcomes.",
        "abstract": "Engrafting the bone marrow cells of a patient with M5 acute myeloid leukemia into immunocompromised mice (AM7577) resulted in serially transferrable stable AML and eventual mortality. The disease starts in the bone marrow and then expands to peripheral areas, which is typical of M5 leukemogenesis, where high leukemic burden in blood is coincident with symptoms/mortality. The leukemic cells in the mice had myeloid morphology, phenotypes, and genotypes (including the internal tandem duplication of FMS-like tyrosine kinase receptor 3 gene [FLT3-ITD]) similar to those of the original patient. Autocrine mechanisms of human granulocyte-macrophage colony-stimulating factor/interleukin-3 likely support AM7577 growth in mice. Treatment with FLT3 TKI (AC220) caused complete remission in peripheral blood, spleen, and bone, along with relief of symptoms and extended life, hinting that FLT3-ITD may be a key leukemogenic driver maintaining the disease. Interestingly, withdrawal of AC220 (high dose) did not result in relapse of disease, suggesting cure. These results, however, are in contrast to cytarabine (AraC) induction treatment: First, although AraC significantly suppresses the diseases in blood, and to a lesser degree in bone marrow and spleen, the suppression is temporary and does not prevent eventual onset of disease/death. Second, the withdrawal of AraC always resulted in rapid relapse in peripheral blood and eventually death. Our observation in this patient-derived model may provide useful information for clinical applications of the two drugs.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoyu An",
                "org": "Crown Bioscience, Inc., Santa Clara, CA, USA."
            },
            {
                "name": "Jinping Liu",
                "org": "Crown Bioscience, Inc., Santa Clara, CA, USA."
            },
            {
                "name": "Na Wang",
                "org": "Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."
            },
            {
                "name": "Di Wang",
                "org": "Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."
            },
            {
                "name": "Liang Huang",
                "org": "Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."
            },
            {
                "name": "Likun Zhang",
                "org": "Crown Bioscience, Inc., Santa Clara, CA, USA."
            },
            {
                "name": "Jie Cai",
                "org": "Crown Bioscience, Inc., Santa Clara, CA, USA."
            },
            {
                "name": "Jean-Pierre Wery",
                "org": "Crown Bioscience, Inc., Santa Clara, CA, USA."
            },
            {
                "name": "Demin Zhou",
                "org": "State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China."
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China."
            },
            {
                "name": "Qi-Xiang Li",
                "org": "Crown Bioscience, Inc., Santa Clara, CA, USA; State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China."
            }
        ],
        "venue": "Experimental hematology",
        "year": 2017
    },
    "xX1SeSXc": {
        "id": "xX1SeSXc",
        "title": "Expression of P-selectin in hematopoietic stem cells of patients with acute leukemia | (Chinese Source)",
        "abstract": "Objective To investigate the expression and clinical significance of P-selectin (CD62P) in bone marrow hematopoietic stem cells of patients with acute leukemia (AL). Methods The CD62P expression in bone marrow mononuclear cells of 15 healthy donors and 56 untreated patients with AL, were examined by flow cytometry. Results The average rate of CD62P expression was (6.72\u00b17.64) % in hematopoietic stem cells (CD45 + CD34 + CD38 -) of the 38 patients with acute myeloid leukemia (AML), was (3.46\u00b12.51) % in hematopoietic stem cells (CD45 + CD34 + CD19 +) of the 12 patients with B-acute lymphoblastic leukemia (B-ALL), and was (6.23\u00b14.95) % in hematopoietic stem cells (CD45 + CD34 + CD7 +) of 6 patients with T-acute lymphoblastic leukemia (T-ALL). The expression rates in those AL patients were higher than that in the healthy controls (1.04 \u00b1 1.23) % (t = 2.847, 3.284, 3.091, respectively, P <0.01), while there was no difference between the control group and the group who reach CR after routine treatment (t =1.932, P >0.05). Furthermore, the leukocyte, hemoglobin and platelet count in CD62P + patients with AML and T-ALL were significantly higher than CD62P - ones(t =4.153, 8.095, 8.289, 7.235, 8.692, 9.832, respectively, P <0.05), but there was no significant difference between CD62 + P and CD62P patients with B-ALL (t =0.340, 1.142, 0.019, respectively, P >0.05). Conclusion The CD62P is one of the markers of platelet activation, and its expression varies in different types of AL. The CD62P in hematopoietic stem cells of AL could be regarded as a new sign for the leukemic stem cells, as well as a helpful prognostic indicator in treatment response assessment.",
        "keywords": [
            "Flow cytometry",
            "Myeloid progenitor cells",
            "P-selectin"
        ],
        "authors": [
            {
                "name": "Min Xiao",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Ying Wu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Yang Yang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Di Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Zhe Geng",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Chunrui Li",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            }
        ],
        "venue": "Journal of Leukemia and Lymphoma",
        "year": 2011
    },
    "TGkSBlIx": {
        "id": "TGkSBlIx",
        "title": "Establishment of reproducible xenotransplantation model of T cell acute lymphoblastic leukemia in NOD/SCID mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shuyan ma",
                "org": ""
            },
            {
                "name": "zhe geng",
                "org": ""
            },
            {
                "name": "pengfei zhou",
                "org": ""
            },
            {
                "name": "jianfeng zhou",
                "org": ""
            },
            {
                "name": "liang huang",
                "org": ""
            },
            {
                "name": "di wang",
                "org": ""
            },
            {
                "name": "na wang",
                "org": ""
            },
            {
                "name": "yan zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Huazhong University of Science and Technology-medical Sciences",
        "year": 2012
    },
    "ubIjpwkN": {
        "id": "ubIjpwkN",
        "title": "Anti-CD30 Chimeric Antigen Receptor T Cell Therapy for CD30+ Relapsed/Refractory Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma Patients",
        "abstract": "Chimeric antigen receptor T (CAR-T) cell therapy had shown remarkable efficacy in B-cell acute lymphoblastic leukemia and several B-cell lymphomas using CD19/22 antigen as target. Similarly, CD30 was found over-expressed on all stage of the cells in classical Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). Given the encouraging clinical success achieved by CD30 monoclonal antibody brentuximab vedotin, targeting CD30 with CAR-T cells would be a promising therapeutic approach for these populations. Here we conducted an open-label, single-center and single-arm pilot study, aimed to evaluate the feasibility and safety of anti-CD30 CAR-T cell therapy relapsed/refractory in HL and ALCL patients. This trial is registered with ChiCTR, number ChiCTR-OPN-16009069.  From August, 2016 to May, 2018, 4 HL and 2 ALCL patients with a median age of 26.5 years (range, 22-55 years) were enrolled in this study. Disease diagnosis and CD30expression was confirmed again by pathology and immunohistochemistry at enrollment. All the patients had relapsed or primary refractory disease, after at least two lines of systemic therapy. A pre-conditioning FC (fludarabin 25mg/m 2 , cyclophosphamide 20mg/kg for 3 days) regimen was give before CAR-T cell infusion. A total dose of 0.7-2.45\u00d710 7  (median 1.175\u00d710 7 ) per kg of CAR-T cells was infused over 3 to 7 consecutive days. The CAR transgene copy, representing CAR-T cells expansion, reached the peak at about 1 week after first administration, and then decreased. CAR transgene copy was still above 100 per \u03bcg genomic DNA in peripheral blood even 6 months after infusion. 5/6 (83.3%) patients had grade 0-1 cytokine release syndrome (CRS), with fever lower than 39\u2103 and duration less than 2 week. Levels of cytokines, including interleukin 6, ferritin and C-reactive protein were monitored. The maximum fold change of the cytokines from baseline was less than 10. No sign of neurotoxicity, bone marrow suppression or other adverse events were observed. The toxicity was generally tolerable, except for one HL patient, who experienced grade 4 CRS, eventually died from pneumorrhagia at the 20 th  day of infusion. The other 5 patients all achieved complete remission (CR) successfully. PET scan showed a CR status as early as the first month after infusion. Although relapse was observed in one HL patient 2 months after infusion, there were 3 of them remained CR state for over 1 year according to PET scan. The median progression free survival was 7 months.  In conclusion, our work demonstrated that CD30 CAR-T cell therapy is efficient and safe for HL and ALCL patients, providing a new option in treating CD30 +  relapsed/refractory lymphomas, while a lager study scale was further demanded in our trial to obtain more robust support.  Disclosures  No relevant conflicts of interest to declare.",
        "keywords": "",
        "authors": [
            {
                "name": "Di Wang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Yi Xiao",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Chunrui Li",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Na Wang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Liang Huang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Yicheng Zhang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Tongcun Zhang",
                "org": "Wuhan University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            }
        ],
        "venue": "Blood",
        "year": 2018
    },
    "KbwLRZhF": {
        "id": "KbwLRZhF",
        "title": "Study of immunophenotype of acute myeloid leukemia patients with NPM1 gene mutation",
        "abstract": "Objective To investigate the immunophenotypic characteristics of acute myeloid leukemia (AML) patients with NPM1 mutation. Methods The immunophenotype of 237 newly diagnosed AML patients were detected by flow cytometry. Real-time quantitative PCR was employed to detect the NPM1 mutation. The immunophenotype was then compared between the NPM1 mutated and wild type patients. Results The incidence of NPM1 mutation was 19.0 R (45/237) in all AML patients. The NPM1 mutated patients had lower expression of CD34, CD117, HLA-DR, CD15 and CD19 than the wild type patients(all P<0.05). For AML patients with normal karyotype, the incidence of NPM1 mutation was 37.7 R (40/106), and the NPM1 mutated patients had lower expression of CD34, HLA-DR, CD15 and CD7 than the wild type patients(all P<0.05). The NPM1 mutated patients with normal karyotype had lower expression of CD34, HLA-DR and CD7 in M1 subtype (all P<0.05); lower expression of HLA-DR and higher expression of CD9 in M2 subtype(all P<0.05); and lower expression of CDm in M5 subtype compared with wild type patients (P < 0.05). Conclusion The immunophenotypic characteristics of AML patients are changed by NPM1 mutation. The changes of immunophenotype varied in different FAB subtypes.",
        "keywords": [
            "Acute",
            "Gene",
            "Immunophenotyping",
            "Leukemia",
            "Nonlymphocytic",
            "NPM1"
        ],
        "authors": [
            {
                "name": "Di Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Min Xiao",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Li Zhu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Zhe Geng",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Zhen Shang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Na Zhang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Yanan Liu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Chunrui Li",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            }
        ],
        "venue": "Journal of Leukemia and Lymphoma",
        "year": 2012
    },
    "CCXvmWPi": {
        "id": "CCXvmWPi",
        "title": "Abstract 3123: Modeling anti-leukemic therapy by patient derived AML xenografts with distinct phenotypes/geneotypes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jinping liu",
                "org": ""
            },
            {
                "name": "xiaoyu an",
                "org": ""
            },
            {
                "name": "na wang",
                "org": "tongji medical college"
            },
            {
                "name": "di wang",
                "org": "tongji medical college"
            },
            {
                "name": "liang huang",
                "org": "tongji medical college"
            },
            {
                "name": "ran wu",
                "org": ""
            },
            {
                "name": "jie cai",
                "org": ""
            },
            {
                "name": "jeanpierre wery",
                "org": ""
            },
            {
                "name": "henry li",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2014
    },
    "uF0UvHdN": {
        "id": "uF0UvHdN",
        "title": "Blocking TRPA1 and TNF-\u03b1 Signal Improves Bortezomib-Induced Neuropathic Pain.",
        "abstract": "We revealed specific signaling pathways leading to neuropathic pain induced by chemotherapeutic BTZ. The data also suggest that blocking TRPA1 and tumor necrosis factor alpha is beneficial to alleviate neuropathic pain during BTZ intervention.",
        "keywords": [
            "Bortezomib",
            "Chemotherapeutics",
            "Multiple myeloma",
            "Neuropathy",
            "TNF-\u03b1",
            "TRPA1"
        ],
        "authors": [
            {
                "name": "Chunrui Li",
                "org": ""
            },
            {
                "name": "Taoran Deng",
                "org": ""
            },
            {
                "name": "Zhen Shang",
                "org": ""
            },
            {
                "name": "Di Wang",
                "org": ""
            },
            {
                "name": "Yi Xiao",
                "org": ""
            }
        ],
        "venue": "Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology",
        "year": 2018
    },
    "XixrVVv0": {
        "id": "XixrVVv0",
        "title": "A Unique Leukemia Mouse Model Established From AML Patient with IDH2 R140Q and FLT3-ITD Mutations Among Other Common AML Mutations",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Di Wang",
                "org": ""
            },
            {
                "name": "Ran Wu",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Liang Huang",
                "org": "Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Taiping Chen",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Yiyou Chen",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Na Wang",
                "org": "Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"
            },
            {
                "name": "Henry Qixiang Li",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Jie Cai",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Jinping Liu",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Hong Wang",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            },
            {
                "name": "Jean-Pierre Wery",
                "org": "Crown Bioscience, Santa Clara, CA, USA,"
            }
        ],
        "venue": "Blood",
        "year": 2012
    },
    "WAU98Sp6": {
        "id": "WAU98Sp6",
        "title": "Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosyn",
        "abstract": "Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.",
        "keywords": "",
        "authors": [
            {
                "name": "Liang Huang",
                "org": ""
            },
            {
                "name": "Dan Liu",
                "org": ""
            },
            {
                "name": "Na Wang",
                "org": ""
            },
            {
                "name": "Shaoping Ling",
                "org": ""
            },
            {
                "name": "Yuting Tang",
                "org": ""
            },
            {
                "name": "Jun Wu",
                "org": ""
            },
            {
                "name": "Lingtong Hao",
                "org": ""
            },
            {
                "name": "Hui Luo",
                "org": ""
            },
            {
                "name": "Xuelian Hu",
                "org": ""
            },
            {
                "name": "Lingshuang Sheng",
                "org": ""
            },
            {
                "name": "Lijun Zhu",
                "org": ""
            },
            {
                "name": "Di Wang",
                "org": ""
            },
            {
                "name": "Yi Luo",
                "org": ""
            },
            {
                "name": "Zhen Shang",
                "org": ""
            },
            {
                "name": "Min Xiao",
                "org": ""
            },
            {
                "name": "Xia Mao",
                "org": ""
            },
            {
                "name": "Kuangguo Zhou",
                "org": ""
            },
            {
                "name": "Lihua Cao",
                "org": ""
            },
            {
                "name": "Lili Dong",
                "org": ""
            },
            {
                "name": "Xinchang Zheng",
                "org": ""
            },
            {
                "name": "Pinpin Sui",
                "org": ""
            },
            {
                "name": "Jianlin He",
                "org": ""
            },
            {
                "name": "Shanlan Mo",
                "org": ""
            },
            {
                "name": "Jin Yan",
                "org": ""
            },
            {
                "name": "Qilin Ao",
                "org": ""
            },
            {
                "name": "Lugui Qiu",
                "org": ""
            },
            {
                "name": "Hongsheng Zhou",
                "org": ""
            },
            {
                "name": "Qifa Liu",
                "org": ""
            },
            {
                "name": "Hongyu Zhang",
                "org": ""
            },
            {
                "name": "Jianyong Li",
                "org": ""
            },
            {
                "name": "Jie Jin",
                "org": ""
            },
            {
                "name": "Li Fu",
                "org": ""
            },
            {
                "name": "Weili Zhao",
                "org": ""
            },
            {
                "name": "Jieping Chen",
                "org": ""
            },
            {
                "name": "Xin Du",
                "org": ""
            },
            {
                "name": "Guoliang Qing",
                "org": ""
            },
            {
                "name": "Hudan Liu",
                "org": ""
            },
            {
                "name": "Xin Liu",
                "org": ""
            },
            {
                "name": "Gang Huang",
                "org": ""
            },
            {
                "name": "Ding Ma",
                "org": ""
            },
            {
                "name": "Jianfeng Zhou",
                "org": ""
            },
            {
                "name": "Qian-fei Wang",
                "org": ""
            }
        ],
        "venue": "Cell Research",
        "year": 2017
    },
    "XIN8ZOSO": {
        "id": "XIN8ZOSO",
        "title": "Comparison between SIL-TAL1 + and SIL-TAL1 \u2212 T-ALL patients.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "di wang",
                "org": ""
            },
            {
                "name": "guangrong zhu",
                "org": ""
            },
            {
                "name": "na wang",
                "org": ""
            },
            {
                "name": "xiaoxi zhou",
                "org": ""
            },
            {
                "name": "yunfan yang",
                "org": ""
            },
            {
                "name": "shiqiu zhou",
                "org": ""
            },
            {
                "name": "jie xiong",
                "org": ""
            },
            {
                "name": "jing he",
                "org": ""
            },
            {
                "name": "lijun jiang",
                "org": ""
            },
            {
                "name": "chunrui li",
                "org": ""
            },
            {
                "name": "danmei xu",
                "org": ""
            },
            {
                "name": "liang huang",
                "org": ""
            },
            {
                "name": "jianfeng zhou",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "0BaEuKDA": {
        "id": "0BaEuKDA",
        "title": "Successful engraftment of human acute lymphoblastic leukemia cells in NOD/SCID mice via intrasplenic inoculation.",
        "abstract": "Acute lymphoblastic leukemia (ALL) is a heterogeneous disorder, and primary drug resistance and relapse are thought to be the main causes for treatment failure in ALL patients. For these refractory or relapsed patients, there is an increasing demand to identify novel therapeutic approaches, which will highly rely on the use of xenotransplantation models in translational research. Given the critical role that the spleen plays in the hematopoiesis and lymphopoiesis in adult mice, intrasplenic inoculation of ALL cells into immunodeficient mice may represent a feasible route for leukemic xenotransplantation. In the present study, engraftments via intrasplenic inoculation in anti-mCD122 mAb conditioned NOD/SCID mice were achieved in 5 out of 11 cases, and the engrafted cells reconstituted a complete leukemic phenotype. The engrafted cells sustained the self-renewal capacity of leukemia-initiating cells as tested by serial xenotransplantation and can be used for evaluation of antileukemic drugs. These data suggest that the combination of intrasplenic inoculation and the targeted depletion of CD122(+) cells could provide a novel approach for the xenotransplantation of ALL cells in NOD/SCID mice. Furthermore, this model can be used for stem cell research, long-term analysis of engraftment kinetics and in vivo drug tests.",
        "keywords": [
            "intrasplenic inoculation",
            "nod/scid mice",
            "cd122",
            "xenotransplantation",
            "acute lymphoblastic leukemia"
        ],
        "authors": [
            {
                "name": "Na Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Liang Huang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Di Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jin Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Lijun Jiang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Kuangguo Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Yunfan Yang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Danmei Xu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            }
        ],
        "venue": "Cancer biology & therapy",
        "year": 2012
    },
    "uGCYqnfZ": {
        "id": "uGCYqnfZ",
        "title": "Establishment of xenotransplantation model of human CN-AML with FLT3-ITD mut /NPM1 \u2212 in NOD/SCID mice",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "na wang",
                "org": ""
            },
            {
                "name": "liang huang",
                "org": ""
            },
            {
                "name": "jianfeng zhou",
                "org": ""
            },
            {
                "name": "zhen shang",
                "org": ""
            },
            {
                "name": "jue wang",
                "org": ""
            },
            {
                "name": "di wang",
                "org": ""
            },
            {
                "name": "min xiao",
                "org": ""
            },
            {
                "name": "tongjuan li",
                "org": ""
            }
        ],
        "venue": "Journal of Huazhong University of Science and Technology-medical Sciences",
        "year": 2013
    },
    "H0KByUzb": {
        "id": "H0KByUzb",
        "title": "SIL-TAL1 rearrangement is related with poor outcome: a study from a Chinese institution.",
        "abstract": "SIL-TAL1 rearrangement is common in T-cell acute lymphoblastic leukemia (T-ALL), however its prognostic implication remains controversial. To investigate the clinical characteristics and outcome of this subtype in Chinese population, we systemically reviewed 62 patients with newly diagnosed T-ALL, including 15 patients with SIL-TAL1 rearrangement. We found that SIL-TAL1(+) T-ALL was characterized by higher white blood cell count (P = 0.029) at diagnosis, predominant cortical T-ALL immunophenotype (P = 0.028) of the leukemic blasts, and a higher prevalence of tumor lysis syndrome (TLS, P<0.001) and disseminated intravascular coagulation (DIC, P<0.001), which led to a higher early mortality (P = 0.011). Compared with SIL-TAL1(-) patients, SIL-TAL1(+) patients had shorter relapse free survival (P = 0.007) and overall survival (P = 0.002). Our NOD/SCID xenotransplantation model also demonstrated that SIL-TAL1(+) mice models had earlier disease onset, higher leukemia cell load in peripheral blood and shorter overall survival (P<0.001). Moreover, the SIL-TAL1(+) mice models exerted a tendency of TLS/DIC and seemed vulnerable towards chemotherapy, which further simulated our clinical settings. These data demonstrate that SIL-TAL1 rearrangement identifies a distinct subtype with inferior outcome which could allow for individual therapeutic stratification for T-ALL patients.",
        "keywords": [
            "phenotype",
            "young adult",
            "retrospective studies"
        ],
        "authors": [
            {
                "name": "Di Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Guangrong Zhu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Na Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Xiaoxi Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Yunfan Yang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Shiqiu Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jie Xiong",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jing He",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Lijun Jiang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Chunrui Li",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Danmei Xu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Liang Huang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "q5gsJhJD": {
        "id": "q5gsJhJD",
        "title": "FLT3-ITD-associated gene-expression signatures in NPM1-mutated cytogenetically normal acute myeloid leukemia.",
        "abstract": "Concomitance of the FLT3-ITD mutation is associated with poor prognosis in NPM1-mutated cytogenetically normal acute myeloid leukemia (CN-AML) patients, and precise studies on its role in leukemogenesis are needed; these may be elucidated at the molecular level by gene express profiling. In the present study, we built a gene-expression-based classifier using prediction analysis of microarray to characterize the FLT3-ITD signature in NPM1-mutated CN-AML patients, which comprised 10 annotated genes, and demonstrated an overall accuracy of 83.8 % in cross-validation. To characterize the signature in another way, differential expression was revealed for 34 genes by class comparison, and the up-regulation of LAPTM4B and MIR155HG was validated by quantitative RT-PCR in our small cohort of NPM1-mutated CN-AML samples, which appeared to be associated with this specific subtype. The 10-gene classifier and differentially expressed genes identified in this study indicate a potential utility for risk-assessed treatment stratification, and suggest new therapeutic targets for these high-risk AML patients.",
        "keywords": [
            "acute myeloid leukemia",
            "flt3-itd",
            "gene-expression signature",
            "npm1"
        ],
        "authors": [
            {
                "name": "Liang Huang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Kuangguo Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Yunfan Yang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Zhen Shang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jue Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Di Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Na Wang",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Danmei Xu",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Huazhong University of Science and Technology(Huazhong University of Science and Technology,Huazhong Univ. of Sci. and Technol.),Wuhan,China"
            }
        ],
        "venue": "International journal of hematology",
        "year": 2012
    },
    "2KOLRLKL": {
        "id": "2KOLRLKL",
        "title": "Application of FICTION technique to the detection of genetic aberrations in multiple myeloma]",
        "abstract": "To investigate the diagnostic value of FICTION (Fluorescence Immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation of Neoplasms) technique, combining immunofluorescence and fluorescence in situ hybridization (FISH), to detect genetic aberrations in multiple myeloma (MM).Bone marrow samples were collected from 18 MM and 2 plasma cell leukemia (PCL) patients. Probes targeting IgH and MMSET were prepared using a Nick Translation Kit from Bacterial artificial chromosome (BAC) clones. The immunophenotyping was achieved via the CD138 tyramide signal amplification (TSA)-mediated immunofluorescence, followed by FISH with the prepared probes \\[t(4;14), t(11;14), t(14;16)\\] and the commercial deletion probes (13q and p53) to detect common genetic aberrations in MM.All the 20 samples were assayed with the probes mentioned above, and revealed 4 cases with t(4;14), 6 with t(11;14), 1 with t(14;16), 3 with p53 deletion; and 8 with 13q deletion. The remaining 4 cases had none of the 5 aberrations.FICTION technique facilitates the detection of genetic abnormalities of MM in situ; enhances both efficiency and sensitivity of positive detection, thus, could be used as the screening test of molecular diagnosis of MM to guide coming-up risk-adapted therapy and evaluate prognosis.",
        "keywords": [],
        "authors": [
            {
                "name": "Wang Di",
                "org": "Department of Hematology, Huazhong University of Science and Technology, Wuhan 430030, China."
            },
            {
                "name": "Huang Liang",
                "org": ""
            },
            {
                "name": "Zhang Heng",
                "org": ""
            },
            {
                "name": "Geng Zhe",
                "org": ""
            },
            {
                "name": "Shang Zhen",
                "org": ""
            },
            {
                "name": "Zhou Jian-feng",
                "org": ""
            },
            {
                "name": "Li Chun-rui",
                "org": ""
            }
        ],
        "venue": "Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi",
        "year": 2011
    },
    "Dp1jj5rh": {
        "id": "Dp1jj5rh",
        "title": "Application of flow cytometric immunophenotyping combined with polymerase chain reaction examination for antigen receptor gene rearrangement in the diagnosis of lymphoproliferative diseases",
        "abstract": "Background and purpose:Lymphoproliferative disease is a disease of highly heterogeneous pathology,immunophenotype and clinical features.The study was aimed to estimate the diagnostic value of flow cytometric immunophenotyping combined with polymerase chain reaction for detection of antigen receptor gene rearrangements for lymphoproliferative diseases.Methods:Fresh samples(lymph nodes,spleen,gastric and hepatic tissue obtained by biopsy or operation)of 79 cases suspected as lymphoproliferative diseases were isolated and their immunophenotypes were examined by flow cytometry.Meanwhile,gene rearrangement and clonal origin of antigen receptors of these samples were analyzed by BIOMED-2 multiplex polymerase chain reaction.And the outcome was compared with pathological diagnosis and immunohistochemical results.Results:Thirty-seven of the 79 cases (46.8%)were confirmed as non-Hodgkin's lymphoma(NHL),3 cases(3.8%)Hodgkin's lymphoma(HL),34 cases (43.0%)benign lymphoid tissues,while 4 cases(5.1%)were finally diagnosed as metastatic malignant tumor.The accurate rates of flow cytometric immunophenotyping and antigen receptor gene rearrangement diagnosis in 19 cases confirmed as B-NHL were both 94.7%(18 cases).Among 18 cases diagnosed as T-NHL,the conformity rate of the former was 72.2%(13 cases)and the latter was 50%(9 cases).In the 34 cases proved to be benign lymphoid tissue, flow cytometric immunophenotyping showed no monoclonal naive cells.However,monoclonal rearrangements were found in 7 samples(16.7%).Polyclonal rearrangements were found in the 3 cases of HL which failed to be confirmed by the flow cytometric immunophenotyping.And a large number of immature cells were detected by flow cytometric immunophenotyping in the 4 metastatic malignant tumor cases(3 with lymph node invasion,1 with liver metastasis), of which no specific antibody was found in 3 cases,while immature myeloid marker was detected in 1 case.And polyclonal rearrangements were showed in all of these 4 samples.Conclusion:Combined use of flow cytometric immunophenotype and antigen receptor gene rearrangement analysis is good auxiliary method for differential diagnosis of lymphoproliferative diseases and identification of different types of malignant lymphoma,particularly in atypical cases.",
        "keywords": [
            "Diagnosis",
            "Polymerase chain reaction",
            "Flow cytometric immunophenotyping",
            "Lymphoproliferative disease"
        ],
        "authors": [
            {
                "name": "GENG Zhe",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            },
            {
                "name": "HUANG Liang",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            },
            {
                "name": "WANG Di",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            },
            {
                "name": "XIONG Jie",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            },
            {
                "name": "ZHU Li",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            },
            {
                "name": "LI CHUN-rui",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            },
            {
                "name": "ZHOU Jian-feng",
                "org": "Department of Hematology,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan Hubei ,China"
            }
        ],
        "venue": "China Oncology",
        "year": 2011
    },
    "2znfYkzq": {
        "id": "2znfYkzq",
        "title": "Tumor Necrosis Factor Receptor Type 1-Associated Death Domain Protein Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia.",
        "abstract": "It is concluded that downregulation of TRADD may be an independent potential prognostic biomarker in AML.",
        "keywords": [
            "Acute myeloid leukemia",
            "Overall survival",
            "Prognosis",
            "Risk classification",
            "Tumor necrosis factor receptor type 1-associated DEATH domain protein"
        ],
        "authors": [
            {
                "name": "Yi Xiao",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: drxiaoyitmc@sina.com."
            },
            {
                "name": "Zhe Geng",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
            },
            {
                "name": "Taoran Deng",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
            },
            {
                "name": "Di Wang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
            },
            {
                "name": "Lijun Jiang",
                "org": "Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."
            }
        ],
        "venue": "The American journal of the medical sciences",
        "year": 2019
    },
    "lASgWmWv": {
        "id": "lASgWmWv",
        "title": "Elevated Serum Exosomal miR-125b Level as a Potential Marker for Poor Prognosis in Intermediate-Risk Acute Myeloid Leukemia.",
        "abstract": "Circulating exosomal miR-125b concentration might be an independent prognostic indicator in intermediate-risk acute myeloid leukemia patients. An elevated miR-125b level indicated higher risks of relapse and overall death.",
        "keywords": [
            "Acute myeloid leukemia",
            "Exosomes",
            "MIRN125 microRNA",
            "Overall death",
            "Recurrence"
        ],
        "authors": [
            {
                "name": "Lijun Jiang",
                "org": ""
            },
            {
                "name": "Taoran Deng",
                "org": ""
            },
            {
                "name": "Di Wang",
                "org": ""
            },
            {
                "name": "Yi Xiao",
                "org": ""
            }
        ],
        "venue": "Acta haematologica",
        "year": 2018
    },
    "cwoO8FHc": {
        "id": "cwoO8FHc",
        "title": "Establishment of reproducible xenotransplantation model of T cell acute lymphoblastic leukemia in NOD/SCID mice.",
        "abstract": "T cell acute lymphoblastic leukemia (T-ALL) is an aggressive leukemia. However the poor prognosis and low morbidity restrict further analysis of the disease. Therefore there is an increasing demand to develop animal models for identifying novel therapeutic approaches. In this study, we inoculated the anti-mouse CD122 monoclonal antibody conditioned NOD/SCID mice with the leukemia cells from 9 T-ALL patients and 1 cell line via the tail vein. Four of the 9 patients and the cell line were successfully engrafted. Flow cytometry detected high percentage of human CD45(+) cells in recipient mice. Immunohistochemistry showed infiltration of human CD45(+) cells in different organs. Serial transplantation was also achieved. In vivo drug treatment showed that dexamethasone could extend survival, which was consistent with clinical observation. These results demonstrated that we successfully established 5 xenotransplantation models of T-ALL in anti-mCD122 mAb conditioned NOD/SCID mice, which recapitulated the characteristics of original disease.",
        "keywords": [
            "xenotransplantation",
            "nod/scid mice",
            "in vivo",
            "t cell acute lymphoblastic leukemia"
        ],
        "authors": [
            {
                "name": "Di WANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Na WANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Yan ZHANG",
                "org": " Crown Bioscience Inc.%%#Beijing%%#,Beijing ,China"
            },
            {
                "name": "Shuyan MA",
                "org": " Crown Bioscience Inc.%%#Beijing%%#,Beijing ,China"
            },
            {
                "name": "Zhe GENG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Pengfei ZHOU",
                "org": " Crown Bioscience Inc.%%#Beijing%%#,Beijing ,China"
            },
            {
                "name": "Jianfeng ZHOU",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            },
            {
                "name": "Liang HUANG",
                "org": " Department of Hematology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,China"
            }
        ],
        "venue": "Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban",
        "year": 2012
    },
    "GMHKtrAe": {
        "id": "GMHKtrAe",
        "title": "Cross-sectional Survey on Nutritional Knowledge,Attitude and Practice of Medical University Students in Wuhan",
        "abstract": "Objective To investigate the current status of nutritional knowledge,attitude and practice(KAP) of medical university students in Wuhan,and to provide scientific evidence for conducting nutritional health education among medical university students.Methods Self-designed KAP questionnaires were applied to students from Tongji Medical College,Huazhong University of Science and Technology.Results Medical students had a good understanding of nutritional knowledge(71.3%).Sex,student source,monthly household income per capita and parents' educational level had some influence on nutritional knowledge.Two-factor linear correlation analysis showed that there was a correlation among nutritional knowledge,attitude and practice.Conclusions It is convenient to provide senior nutritional health education for medical university students,for the nutrition attitude of them is well.",
        "keywords": [
            "Knowledge-attitude-practice(KAP)",
            "Medical university students",
            "Nutrition"
        ],
        "authors": [
            {
                "name": "ZHAO Hai-yue",
                "org": "School of Second Clinical Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei,China"
            },
            {
                "name": "ZHU Lei-lei",
                "org": "School of Second Clinical Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei,China"
            },
            {
                "name": "WANG Di",
                "org": "School of Second Clinical Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan ,Hubei,China"
            }
        ],
        "venue": "Practical Preventive Medicine",
        "year": 2012
    },
    "IdM1Q3nH": {
        "id": "IdM1Q3nH",
        "title": "Hydrogen-rich gas production from pyrolysis of biomass in an autogenerated steam atmosphere",
        "abstract": "Hydrogen-rich gas production from pyrolysis of biomass in an autogenerated steam atmosphere was proposed. The scheme aims to utilize steam autogenerated from biomass moisture as a reactant to react with the intermediate products of pyrolysis to produce additional hydrogen. In the present Article, the effect of reactor temperature, moisture content, heating rate, and sweeping gas flow rate on the process was investigated experimentally. Measurement of the atomic structures of chars produced from pyrolysis of wet/predried biomass was carried out with XRD. The results show that heating rate is a key role in the process. Under fast-heating conditions, drying and pyrolysis occurred in a relatively shorter time, which enhances the interactions between the autogenerated steam and the intermediate products and hence produces more hydrogen. Under slow-heating conditions, however, the autogenerated steam from moisture will be partially purged away from the reaction zone, leading to a weakened effect on the subsequent reactions. The use of sweeping gas is unfavorable to hydrogen production due to the reduced residence time of both the autogenerated steam and the volatile. Moisture content has a great effect on hydrogen production. The H2 yield and content increases with the moisture content. Under the conditions of fast-heating rate and without the use of sweeping gas, the pyrolysis of BW (wet biomass with a moisture content of 47.4%, wet basis) exhibits higher H2 yield of 495 mL/g, H2 content of 38.1 vol %, and carbon conversion efficiency of 87.3% than those (267 mL/g, 26.9 vol %, and 68.2%) from the pyrolysis of BTD (the predried biomass with a moisture content of 7.9%, wet basis). The comparison of atomic structure of chars from BW and BTD further confirms that directly pyrolyzing wet biomass without predried treatment favors the pyrolysis to a deeper extent. \u00a9 2009 American Chemical Society.",
        "keywords": [
            "null"
        ],
        "authors": [
            {
                "name": "Guoxin Hu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Hao Huang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "YanHong Li",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Energy and Fuels",
        "year": 2009
    },
    "EviCcy4C": {
        "id": "EviCcy4C",
        "title": "Mixing Characteristics of a Novel Annular Spouted Bed with Several Angled Air Nozzles",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Hao Huang",
                "org": ""
            },
            {
                "name": "Guoxin Hu",
                "org": ""
            }
        ],
        "venue": "Industrial & Engineering Chemistry Research",
        "year": 2007
    },
    "Yv1vmjQo": {
        "id": "Yv1vmjQo",
        "title": "Experimental study on pyrolysis of coal particle-heat carrying medium mixtures in a rotating cone reactor",
        "abstract": "A rotating cone shaped reactor has been designed for studying pyrolytic process of coal particles mixed with a heat carrying medium. The effects of the coal particles' mean size, pyrolysis temperature, cone' s rotational speed and the proportion of the mixture on the coal' s pyrolytic weight loss were tot determined. Experimental results show that the pyrolytic weight loss drops noticeably with increasing coal particle size, with reducing pyrolysis temperature and the cone' s rotational speed. Moreover, addition of a heat carrying medium to the coal particles enhances the heat transfer effect within the mixture; the pyrolytic weight loss tends to increase with the heat carrier's increasing share. Study results are helpful for deepening our knowledge concerning the coal pyrolysis mechanism and may serve as a reference for further research on rotating pyrolytic reactors and be helpful for popularizing their application.",
        "keywords": [
            "Coal",
            "Engineering thermophysics",
            "Heat carrier",
            "Pyrolytic reactor",
            "Rotating cone",
            "Weight loss"
        ],
        "authors": [
            {
                "name": "Zheng Wang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "HaoJie Fan",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Xiwu Gong",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Hao Huang",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            },
            {
                "name": "Guoxin Hu",
                "org": "Shanghai Jiaotong University(Shanghai Jiaotong University,Shanghai Jiao Tong University,Shanghai Jiaotong Univ.),Shanghai,China"
            }
        ],
        "venue": "Dongli Gongcheng/Power Engineering",
        "year": 2007
    },
    "plsahHl0": {
        "id": "plsahHl0",
        "title": "Effects of Geometric Parameters and Operating Conditions on Granular Flow in a Modified Rotating Cone",
        "abstract": "",
        "keywords": [
            "operant conditioning"
        ],
        "authors": [
            {
                "name": "Guoxin Hu",
                "org": ""
            },
            {
                "name": "Xiwu Gong",
                "org": ""
            },
            {
                "name": "Hao Huang",
                "org": ""
            },
            {
                "name": "Yanhong Li",
                "org": ""
            }
        ],
        "venue": "Industrial & Engineering Chemistry Research",
        "year": 2007
    },
    "D4TAv6XV": {
        "authors": [
            {
                "name": "Bo Jiang",
                "org": "Department of Cardiothoracic Surgery, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Xiaoying Zhang",
                "org": "Department of Cardiothoracic Surgery, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Dongmei Di",
                "org": "Department of Cardiothoracic Surgery, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Guanghua Luo",
                "org": "Comprehensive Laboratory, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Yuanping Shi",
                "org": "Comprehensive Laboratory, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Jun Zhang",
                "org": "Comprehensive Laboratory, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Maria Berggren-S\u00f6derlund",
                "org": "Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University"
            },
            {
                "name": "Peter Nilsson-Ehle",
                "org": "Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University"
            },
            {
                "name": "Ning Xu",
                "org": "Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University"
            }
        ],
        "title": "Hyperglycemia-induced downregulation of apolipoprotein M expression is not via the hexosamine pathway",
        "abstract": "Background: We previously demonstrated that hyperglycemia could suppress apolipoprotein M (apoM) synthesis both in vivo and in vitro; however, the mechanism of hyperglycemia-induced downregulation of apoM expression is unknown yet. Methods: In the present study we further examined if hexosamine pathway, one of the most important pathways of glucose turnover, being involved in modulating apoM expression in the hyperglycemia condition. We examined the effect of glucosamine, a prominent component of hexosamine pathway and intracellular mediator of insulin resistance, on apoM expression in HepG2 cells and in rat's models. In the present study we also determined apolipoprotein A1 (apoA1) as a control gene. Results: Our results demonstrated that glucosamine could even up-regulate both apoM and apoA1 expressions in HepG2 cell cultures. The glucosamine induced upregulation of apoM expression could be blocked by addition of azaserine, an inhibitor of hexosamine pathway. Moreover, intravenous infusion of glucosamine could enhance hepatic apoM expression in rats, although serum apoM levels were not significantly influences. Conclusions: It is concluded that both exogenous and endogenous glucosamine were essential for the over-expression of apoM, which may suggest that the increased intracellular content of glucosamine does not be responsible for the depressed apoM expression at hyperglycemia condition.",
        "keywords": [
            "Apolipoprotein M",
            "Glucosamine",
            "Hexosamine pathway",
            "Hyperglycemia"
        ],
        "venue": "Lipids in Health and Disease",
        "year": 2015,
        "id": "D4TAv6XV"
    },
    "QnH5YJ7H": {
        "id": "QnH5YJ7H",
        "title": "Targeting mitochondria-associated membranes as a potential therapy against endothelial injury induced by hypoxia.",
        "abstract": "Mitochondrial dysfunction plays a principal role in hypoxia-induced endothelial injury, which is involved in hypoxic pulmonary hypertension and ischemic cardiovascular diseases. Recent studies\u00a0have identified mitochondria-associated membranes (MAMs) that modulate mitochondrial function under a variety of pathophysiological conditions\u00a0such as high-fat diet-mediated insulin resistance, hypoxia reoxygenation-induced myocardial death, and hypoxia-evoked vascular smooth muscle cell proliferation. However, the role of MAMs in hypoxia-induced endothelial injury remains unclear. To explore this further, human umbilical vein endothelial cells and human pulmonary artery endothelial cells were exposed to hypoxia (1% O ) for 24\u2009hours. An increase in MAM formation was uncovered by immunoblotting and immunofluorescence. Then, we performed small interfering RNA transfection targeted to MAM constitutive proteins and explored the biological effects. Knockdown of MAM constitutive proteins attenuated hypoxia-induced elevation of mitochondrial Ca and repressed mitochondrial impairment, leading to an increase in mitochondrial membrane potential and ATP production and a decline in reactive oxygen species. Then, we found that MAM disruption mitigated cell apoptosis and promoted cell survival. Next, other protective effects, such as those pertaining to\u00a0the repression of inflammatory response and the promotion of NO synthesis, were investigated. With the disruption of MAMs under hypoxia, inflammatory molecule expression was repressed, and the eNOS-NO pathway was enhanced. This study demonstrates that the disruption of MAMs might be of therapeutic value for treating endothelial injury under hypoxia, suggesting a novel strategy for preventing hypoxic pulmonary hypertension and ischemic injuries.",
        "keywords": [
            "endothelial cells",
            "hypoxia",
            "mitochondria",
            "mitochondria-associated membranes"
        ],
        "authors": [
            {
                "name": "Yi-Dong Yang",
                "org": "Key Laboratory of High Altitude Medicine, PLA, Chongqing, China."
            },
            {
                "name": "Man-Man Li",
                "org": "Genetics Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, China."
            },
            {
                "name": "Gang Xu",
                "org": "Key Laboratory of High Altitude Medicine, PLA, Chongqing, China."
            },
            {
                "name": "Er-Long Zhang",
                "org": "Key Laboratory of High Altitude Medicine, PLA, Chongqing, China."
            },
            {
                "name": "Jian Chen",
                "org": "Key Laboratory of High Altitude Medicine, PLA, Chongqing, China."
            },
            {
                "name": "Binda Sun",
                "org": "Key Laboratory of High Altitude Medicine, PLA, Chongqing, China."
            },
            {
                "name": "De-Wei Chen",
                "org": "Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University (Third Military Medical University), Chongqing, China."
            },
            {
                "name": "Yu-Qi Gao",
                "org": "Key Laboratory of High Altitude Medicine, PLA, Chongqing, China."
            }
        ],
        "venue": "Journal of cellular biochemistry",
        "year": 2019
    },
    "e4Tr9xGG": {
        "id": "e4Tr9xGG",
        "title": "Metabolite Modulation in Human Plasma in the Early Phase of Acclimatization to Hypobaric Hypoxia",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Wen-Ting Liao",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Bao Liu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Yi-Xing Gao",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Fu-Yu Liu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Gang Xu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Bing-Da Sun",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Er-Long Zhang",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Zhi-Bin Yuan",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Yu-Qi Gao",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Jian Chen",
                "org": "Department of Pathophysiology and High Altitude Physiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Gang Zhang",
                "org": "Department of High Altitude Military Hygiene, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Wen-Ting Liao",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Bao Liu",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Jian Chen",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Yi-Xing Gao",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Fu-Yu Liu",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Gang Xu",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Bing-Da Sun",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Er-Long Zhang",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Zhi-Bin Yuan",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Gang Zhang",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Yu-Qi Gao",
                "org": "Key Laboratory of High Altitude Medicine (Third Military Medical University), Ministry of Education, Chongqing 400038, China"
            },
            {
                "name": "Wen-Ting Liao",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Bao Liu",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Jian Chen",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Yi-Xing Gao",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Fu-Yu Liu",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Gang Xu",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Bing-Da Sun",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Er-Long Zhang",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Zhi-Bin Yuan",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Gang Zhang",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Yu-Qi Gao",
                "org": "The Key Laboratory of High Altitude Medicine, People\u2019s Liberation Army, Chongqing 400038, China"
            },
            {
                "name": "Jian-Hua Cui",
                "org": "18th Hospital, People\u2019s Liberation Army, Yecheng, Xinjiang, China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "RYhcDpcw": {
        "id": "RYhcDpcw",
        "title": "A Signature of Circulating microRNAs Predicts the Susceptibility of Acute Mountain Sickness.",
        "abstract": " Acute mountain sickness (AMS) is a common disabling condition in individuals experiencing high altitudes, which may progress to life-threatening high altitude cerebral edema. Today, no established biomarkers are available for prediction the susceptibility of AMS. MicroRNAs emerge as promising sensitive and specific biomarkers for a variety of diseases. Thus, we sought to identify circulating microRNAs suitable for prediction the susceptible of AMS before exposure to high altitude.  We enrolled 109 healthy man adults and collected blood samples before their exposure to high altitude. Then we took them to an elevation of 3648 m for 5 days. Circulating microRNAs expression was measured by microarray and quantitative reverse-transcription polymerase chain reaction (qRT-PCR). AMS was defined as Lake Louise score \u22653 and headache using Lake Louise Acute Mountain Sickness Scoring System.  A total of 31 microRNAs were differentially expressed between AMS and Non-AMS groups, 15 up-regulated and 16 down-regulated. Up-regulation of miR-369-3p, miR-449b-3p, miR-136-3p, and miR-4791 in patients with AMS compared with Non-AMS individuals were quantitatively confirmed using qRT-PCR (all,  < 0.001). With multiple logistic regression analysis, a unique signature encompassing miR-369-3p, miR-449b-3p, and miR-136-3p discriminate AMS from Non-AMS (area under the curve 0.986, 95%CI 0.970-1.000,  < 0.001, LR+: 14.21, LR-: 0.08). This signature yielded a 92.68% sensitivity and a 93.48% specificity for AMS vs. Non-AMS.  The study here, for the first time, describes a signature of three circulating microRNAs as a robust biomarker to predict the susceptibility of AMS before exposure to high altitude.",
        "keywords": [
            "acute mountain sickness",
            "circulating microRNAs",
            "prediction",
            "signature"
        ],
        "authors": [
            {
                "name": "Bao Liu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "He Huang",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "Gang Wu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "Gang Xu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "Bing-Da Sun",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "Er-Long Zhang",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "Jian Chen",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            },
            {
                "name": "Yu-Qi Gao",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical UniversityChongqing, China; Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of EducationChongqing, China; Key Laboratory of High Altitude Medicine, PLAChongqing, China."
            }
        ],
        "venue": "Frontiers in physiology",
        "year": 2017
    },
    "9TJricJm": {
        "id": "9TJricJm",
        "title": "UPLC\u2011QTOFMS\u2011based metabolomic analysis of the serum of hypoxic preconditioning mice.",
        "abstract": "Hypoxic preconditioning (HPC) is well\u2011known to exert a protective effect against hypoxic injury; however, the underlying molecular mechanism remains unclear. The present study utilized a serum metabolomics approach to detect the alterations associated with HPC. In the present study, an animal model of HPC was established by exposing adult BALB/c mice to acute repetitive hypoxia four times. The serum samples were collected by orbital blood sampling. Metabolite profiling was performed using ultra\u2011performance liquid chromatography\u2011quadrupole time\u2011of\u2011flight mass spectrometry (UPLC\u2011QTOFMS), in conjunction with univariate and multivariate statistical analyses. The results of the present study confirmed that the HPC mouse model was established and refined, suggesting significant differences between the control and HPC groups at the molecular levels. HPC caused significant metabolic alterations, as represented by the significant upregulation of valine, methionine, tyrosine, isoleucine, phenylalanine, lysophosphatidylcholine (LysoPC; 16:1), LysoPC (22:6), linoelaidylcarnitine, palmitoylcarnitine, octadecenoylcarnitine, taurine, arachidonic acid, linoleic acid, oleic acid and palmitic acid, and the downregulation of acetylcarnitine, malate, citrate and succinate. Using MetaboAnalyst 3.0, a number of key metabolic pathways were observed to be acutely perturbed, including valine, leucine and isoleucine biosynthesis, in addition to taurine, hypotaurine, phenylalanine, linoleic acid and arachidonic acid metabolism. The results of the present study provided novel insights into the mechanisms involved in the acclimatization of organisms to hypoxia, and demonstrated the protective mechanism of HPC.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Liu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Gang Zhan",
                "org": "Key Laboratory of High Altitude Medicine, Ministry of Education, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Dewei Chen",
                "org": "Key Laboratory of High Altitude Medicine, Ministry of Education, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Jian Chen",
                "org": "Key Laboratory of High Altitude Medicine, Ministry of Education, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Zhi-Bin Yuan",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Er-Long Zhang",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Yi-Xing Gao",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Gang Xu",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Bing-Da Sun",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            },
            {
                "name": "Wenting Liao",
                "org": "Department of Pharmaceutical Analysis, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China."
            },
            {
                "name": "Yu-Qi Gao",
                "org": "Institute of Medicine and Hygienic Equipment for High Altitude Region, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China."
            }
        ],
        "venue": "Molecular medicine reports",
        "year": 2017
    },
    "Bthkehnu": {
        "id": "Bthkehnu",
        "title": "Arachidonic Acid Metabolism Pathway Is Not Only Dominant in Metabolic Modulation but Associated With Phenotypic Variation After Acute Hypoxia Exposure.",
        "abstract": " The modulation of arachidonic acid (AA) metabolism pathway is identified in metabolic alterations after hypoxia exposure, but its biological function is controversial. We aimed at integrating plasma metabolomic and transcriptomic approaches to systematically explore the roles of the AA metabolism pathway in response to acute hypoxia using an acute mountain sickness (AMS) model.  Blood samples were obtained from 53 enrolled subjects before and after exposure to high altitude. Ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry and RNA sequencing were separately performed for metabolomic and transcriptomic profiling, respectively. Influential modules comprising essential metabolites and genes were identified by weighted gene co-expression network analysis (WGCNA) after integrating metabolic information with phenotypic and transcriptomic datasets, respectively.  Enrolled subjects exhibited diverse response manners to hypoxia. Combined with obviously altered heart rate, oxygen saturation, hemoglobin, and Lake Louise Score (LLS), metabolomic profiling detected that 36 metabolites were highly related to clinical features in hypoxia responses, out of which 27 were upregulated and nine were downregulated, and could be mapped to AA metabolism pathway significantly. Integrated analysis of metabolomic and transcriptomic data revealed that these dominant molecules showed remarkable association with genes in gas transport incapacitation and disorders of hemoglobin metabolism pathways, such as ALAS2, HEMGN. After detailed description of AA metabolism pathway, we found that the molecules of 15-d-PGJ2, PGA2, PGE2, 12-O-3-OH-LTB4, LTD4, LTE4 were significantly up-regulated after hypoxia stimuli, and increased in those with poor response manner to hypoxia particularly. Further analysis in another cohort showed that genes in AA metabolism pathway such as PTGES, PTGS1, GGT1, TBAS1 et al. were excessively elevated in subjects in maladaptation to hypoxia.  This is the first study to construct the map of AA metabolism pathway in response to hypoxia and reveal the crosstalk between phenotypic variation under hypoxia and the AA metabolism pathway. These findings may improve our understanding of the advanced pathophysiological mechanisms in acute hypoxic diseases and provide new insights into critical roles of the AA metabolism pathway in the development and prevention of these diseases.",
        "keywords": [
            "WGCNA",
            "arachidonic acid",
            "hypoxia",
            "metabolomics",
            "transcriptomics"
        ],
        "authors": [
            {
                "name": "Chang Liu",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            },
            {
                "name": "Bao Liu",
                "org": "The 12th Hospital of Chinese People's Liberation Army, Kashi, China."
            },
            {
                "name": "Lu Liu",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            },
            {
                "name": "Er-Long Zhang",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            },
            {
                "name": "Bind-da Sun",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            },
            {
                "name": "Gang Xu",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            },
            {
                "name": "Jian Chen",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            },
            {
                "name": "Yu-Qi Gao",
                "org": "Key Laboratory of High Altitude Medicine, People's Liberation Army, Chongqing, China."
            }
        ],
        "venue": "Frontiers in physiology",
        "year": 2018
    },
    "bOSytZuM": {
        "id": "bOSytZuM",
        "title": "IL-10 Dysregulation in Acute Mountain Sickness Revealed by Transcriptome Analysis.",
        "abstract": "Acute mountain sickness (AMS), which may progress to life-threatening high-altitude cerebral edema, is a major threat to millions of people who live in or travel to high altitude. Although studies have revealed the risk factors and pathophysiology theories of AMS, the molecular mechanisms of it do not comprehensively illustrate. Here, we used a system-level methodology, RNA sequencing, to explore the molecular mechanisms of AMS at genome-wide level in 10 individuals. After exposure to high altitude, a total of 1,164 and 1,322 differentially expressed transcripts were identified in AMS and non-AMS groups, respectively. Among them, only 328 common transcripts presented between the two groups. Immune and inflammatory responses were overrepresented in participants with AMS, but not in non-AMS individuals. Anti-inflammatory cytokine IL10 and inflammation cytokines IF17F and CCL8 exhibited significantly different genetic connectivity in AMS compared to that of non-AMS individuals based on network analysis. IL10 was downregulated and both IF17F and CCL8 were upregulated in AMS individuals. Moreover, the serum concentration of IL10 significantly decreased in AMS patients after exposure to high altitude (\u2009=\u20090.001) in another population (\u2009=\u200922). There was a large negative correlation between the changes in IL10 concentration, (22)\u2009=\u2009-0.52, \u2009=\u20090.013, and Lake Louise Score. Taken together, our analysis provides unprecedented characterization of AMS transcriptome and identifies that genes involved in immune and inflammatory responses were disturbed in AMS individuals by high-altitude exposure. The reduction of IL10 after exposure to high altitude was associated with AMS.",
        "keywords": [
            "RNA-seq",
            "acute mountain sickness",
            "immune response",
            "inflammatory response",
            "interleukin-10"
        ],
        "authors": [
            {
                "name": "Bao Liu",
                "org": "Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of Education, Chongqing, China."
            },
            {
                "name": "Jian Chen",
                "org": "Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of Education, Chongqing, China."
            },
            {
                "name": "Long Zhang",
                "org": "BGI-Shenzhen, Shenzhen, China."
            },
            {
                "name": "Yixing Gao",
                "org": "Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of Education, Chongqing, China."
            },
            {
                "name": "Jianhua Cui",
                "org": "Research Center of PLA for Prevention and Treatment of High Mountain Sickness, The 18th Hospital of PLA, Xinjiang, China."
            },
            {
                "name": "Erlong Zhang",
                "org": "Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of Education, Chongqing, China."
            },
            {
                "name": "Gang Xu",
                "org": "Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of Education, Chongqing, China."
            },
            {
                "name": "Yan Liang",
                "org": "BGI-Shenzhen, Shenzhen, China."
            },
            {
                "name": "Yu Liang",
                "org": "BGI-Shenzhen, Shenzhen, China."
            },
            {
                "name": "Jian Wang",
                "org": "BGI-Shenzhen, Shenzhen, China."
            },
            {
                "name": "Yuqi Gao",
                "org": "Key Laboratory of High Altitude Environmental Medicine, Third Military Medical University, Ministry of Education, Chongqing, China."
            }
        ],
        "venue": "Frontiers in immunology",
        "year": 2017
    },
    "lIdXeJHL": {
        "id": "lIdXeJHL",
        "title": "In situ studies on the bioaccumulation of microcystins in the phytoplanktivorous silver carp (Hypophthalmichthys molitrix) stocked in Lake Taihu with dense toxic Microcystis blooms",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "dawen zhang",
                "org": ""
            },
            {
                "name": "hua yang",
                "org": ""
            },
            {
                "name": "zhixin ke",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "ping xie",
                "org": ""
            }
        ],
        "venue": "Aquaculture",
        "year": 2006
    },
    "iK2KDRv8": {
        "id": "iK2KDRv8",
        "title": "Quantitatively evaluating detoxification of the hepatotoxic microcystin-LR through the glutathione (GSH) pathway in SD rats",
        "abstract": "Glutathione (GSH) plays crucial roles in antioxidant defense and detoxification metabolism of microcystin-LR (MC-LR). However, the detoxification process of MC-LR in mammals remains largely unknown. This paper, for the first time, quantitatively analyzes MC-LR and its GSH pathway metabolites (MC-LR-GSH and MC-LR-Cys) in the liver of Sprague-Dawley (SD) rat after MC-LR exposure. Rats received intraperitoneal (i.p.) injection of 0.25 and 0.5 lethal dose 50 (LD50) of MC-LR with or without pretreatment of buthionine-(S,R)-sulfoximine (BSO), an inhibitor of GSH synthesis. The contents of MC-LR-GSH were relatively low during the experiment; however, the ratio of MC-LR-Cys to MC-LR reached as high as 6.65 in 0.5 LD50 group. These results demonstrated that MC-LR-GSH could be converted to MC-LR-Cys efficiently, and this metabolic rule was in agreement with the data of aquatic animals previously reported. MC-LR contents were much higher in BSO + MC-LR-treated groups than in the single MC-LR-treated groups. Moreover, the ratio of MC-LR-Cys to MC-LR decreased significantly after BSO pretreatment, suggesting that the depletion of GSH induced by BSO reduced the detoxification of MCs. Moreover, MC-LR remarkably induced liver damage, and the effects were more pronounced in BSO pretreatment groups. In conclusion, this study verifies the role of GSH in the detoxification of MC-LR and furthers our understanding of the biochemical mechanism for SD rats to counteract toxic cyanobacteria.",
        "keywords": [],
        "authors": [
            {
                "name": "xiaochun guo",
                "org": "huazhong agricultural university"
            },
            {
                "name": "liang chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jun chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "ping xie",
                "org": "huazhong agricultural university"
            },
            {
                "name": "shangchun li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jun he",
                "org": "chinese academy of sciences"
            },
            {
                "name": "wei li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "huihui fan",
                "org": "huazhong agricultural university"
            },
            {
                "name": "dezhao yu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "cheng zeng",
                "org": "huazhong agricultural university"
            }
        ],
        "venue": "Environmental Science and Pollution Research",
        "year": 2015
    },
    "Ux3m3Kdh": {
        "id": "Ux3m3Kdh",
        "title": "A review of neurotoxicity of microcystins",
        "abstract": "Cyanobacterial blooms-produced microcystins are secondary metabolites which can accumulate in the food chain and contaminate water, thus posing a potential threat to the health of aquatic animals and even humans. Microcystin toxicity affects not only the liver but also the other organs, i.e., the brain. The serious neurotoxicity effects caused by microcystins then lead to various symptoms. This review focuses on the neurotoxicity of microcystins. Microcystins can cross blood-brain barrier with the transport of Oatps/OATPs, causing neurostructural, functional, and behavioral changes. In this review, potential uptake mechanisms and neurotoxicity mechanisms are summarized, including neurotransmissions, neurochannels, signal transduction, oxidative stress, and cytoskeleton disruption. However, further researches are needed for detailed studies on signaling pathways and the downstream pathways of neurotoxicity of microcystins.",
        "keywords": "",
        "authors": [
            {
                "name": "Yufei Hu",
                "org": "Institute of Hydrobiology, Chinese Academy of Sciences"
            },
            {
                "name": "Jun Chen",
                "org": "Institute of Hydrobiology, Chinese Academy of Sciences"
            },
            {
                "name": "Huihui Fan",
                "org": "Wenzhou Medical University"
            },
            {
                "name": "Ping Xie",
                "org": "Institute of Hydrobiology, Chinese Academy of Sciences"
            },
            {
                "name": "Jun He",
                "org": "Institute of Hydrobiology, Chinese Academy of Sciences"
            }
        ],
        "venue": "Environmental Science and Pollution Research",
        "year": 2016
    },
    "dQhh4boM": {
        "id": "dQhh4boM",
        "title": "Microcystin-LR retards gonadal maturation through disrupting the growth hormone/insulin-like growth factors system in zebrafish.",
        "abstract": "Recent studies have documented that microcystins (MCs) have potential toxic effects on growth and reproduction in fish. However, no systematic data exist on whether MCs cause gonadal development retardation through disrupting the growth hormone/insulin-like growth factors (GH/IGFs) system. To this end, zebrafish hatchlings (5 d post-fertilization) were exposed to 0, 0.3, 3 and 30\u00b5g/L microcystin-LR (MC-LR) for 90 d until they reached sexual maturity. Life-cycle exposure to MC-LR caused delayed ovarian maturation and sperm development along with ultrapathological lesions in the brain and liver. Moreover, the retarded gonadal development was accompanied by an inhibition of the GH/IGFs system, which was characterized by significant decreases in the transcriptional levels of brain gh (males only), hepatic igf2a and igf2b as well as gonadal igf1 (males only), igf3 and igf2r. These findings for the first time point to the influence of MC-LR on fish gonadal development via the GH/IGFs system. Also, sex-differential impairments suggested that gonadal development of males is more vulnerable than that of female to MC-LR. Our results provide evidence that MC-LR at environmentally relevant concentrations is able to induce impairments on fish gonadal development.",
        "keywords": [
            "GH/IGFs axis",
            "Life-cycle exposure",
            "Microcystins",
            "Reproductive development",
            "Retardation"
        ],
        "authors": [
            {
                "name": "Jie Hou",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China."
            },
            {
                "name": "Yujing Su",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China."
            },
            {
                "name": "Wang Lin",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China."
            },
            {
                "name": "Honghui Guo",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430072, PR China."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430072, PR China."
            },
            {
                "name": "Zemao Gu",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China; Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan 430070, PR China. Electronic address: guzemao@mail.hzau.edu.cn."
            },
            {
                "name": "Li Li",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China; Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, Wuhan 430070, PR China; Freshwater Aquaculture Collaborative Innovation Center of Hubei Province, Wuhan 430070, PR China. Electronic address: foreverlili78@mail.hzau.edu.cn."
            }
        ],
        "venue": "Ecotoxicology and environmental safety",
        "year": 2017
    },
    "7Xi92ppb": {
        "id": "7Xi92ppb",
        "title": "Chemical proteomic analysis of the potential toxicological mechanisms of microcystin-RR in zebrafish ( Danio rerio ) liver: STUDY OF THE TOXICITY MECHANISMS OF MICROCYSTIN-RR IN ZEBRAFISH LIVER",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ping xie",
                "org": ""
            },
            {
                "name": "sujuan zhao",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "xun tuo",
                "org": ""
            }
        ],
        "venue": "Environmental Toxicology",
        "year": 2015
    },
    "AekG6nPe": {
        "id": "AekG6nPe",
        "title": "Perfluorododecanoic acid exposure induced developmental neurotoxicity in zebrafish embryos.",
        "abstract": "Perfluorododecanoic acid (PFDoA), an artificial perfluorochemical, has been widely distributed in different ambient media and has been reported to have the potential to cause developmental neurotoxicity. However, the specific mechanism is largely unknown. In the current study, zebrafish embryos were treated with 0, 0.24, 1.2, and 6\u202fmg/L PFDoA for 120\u202fh. Exposure to PFDoA causes serious decreases in hatching delay, body length, as well as decreased locomotor speed in zebrafish larvae. Additionally, the acetylcholine (ACh) content as well as acetylcholinesterase (AChE) activity were determined to be significantly downregulated in PFDoA treatment groups. The level of dopamine was upregulated significantly after treating with 1.2 and 6\u202fmg/L of PFDoA. Gene expressions related to the nervous system development were also analyzed, with the exception of the gene mesencephalic astrocyte-derived neurotrophic factor (manf), which is upregulated in the 6\u202fmg/L treatment group. All other genes were significantly downregulated in larvae in the PFDoA group in different degrees. In general, the results demonstrated that PFDoA exposure could result in the disruption of the cholinergic system, dopaminergic signaling, and the central nervous system.",
        "keywords": [
            "Acetylcholine",
            "Developmental neurotoxicity",
            "Dopamine",
            "PFDoA",
            "Zebrafish embryo"
        ],
        "authors": [
            {
                "name": "Xiaochun Guo",
                "org": "State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address: guoxiaochun419@163.com."
            },
            {
                "name": "Shengnan Zhang",
                "org": "State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; College of Environment and Resource, Shanxi University, Taiyuan, 030006, China."
            },
            {
                "name": "Shaoyong Lu",
                "org": "State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address: lushy2000@163.com."
            },
            {
                "name": "Binghui Zheng",
                "org": "State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China."
            },
            {
                "name": "Guangyu Li",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China."
            },
            {
                "name": "Chunsheng Liu",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China."
            },
            {
                "name": "Qin Wu",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China."
            },
            {
                "name": "Houcheng Cheng",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, China."
            },
            {
                "name": "Nan Sang",
                "org": "College of Environment and Resource, Shanxi University, Taiyuan, 030006, China."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "s3RD1vhO": {
        "id": "s3RD1vhO",
        "title": "A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure.",
        "abstract": "There is mounting evidence indicating that microcystins (MCs) are heptapeptide toxins. Recent studies have also shown that MCLR can transfer from mother to offspring, but it is unclear whether maternal MCLR can influence the liver of offspring or not. In this study, pregnant SD rats were injected intraperitoneally with a saline solution (control) or 10\u00a0\u03bcg/kg MCLR per day from gestational day 8 (GD8) to postnatal day 15 (PD15) for a total of 4 weeks. 2-DE and MALDI-TOF-TOF mass spectrometry were used to screen for MCLR target proteins in the livers of rat pups. Our results demonstrated that MCLR could accumulate in the livers of neonatal rats. Proteomics studies also showed that MCLR significantly influenced many proteins, including those involved in the cytoskeleton, metabolism and particularly oxidative stress. In addition, MCLR induced cellular structural damage and resulted in the production of intracellular reactive oxygen species (ROS) and lipid peroxidation. Moreover, protein phosphatase (PP) activity was inhibited and some serum biochemistry parameters were altered. These results suggest an early molecular mechanism behind the hepatotoxicity induced by maternal MC exposure and highlight the importance of monitoring MC concentrations in new-born mammals. ",
        "keywords": [
            "Liver",
            "MCLR",
            "Oxidative damage",
            "Proteomics",
            "Rat pups"
        ],
        "authors": [
            {
                "name": "Sujuan Zhao",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China. Electronic address: xieping@ihb.ac.cn."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            },
            {
                "name": "Luyi Liu",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            },
            {
                "name": "Huihui Fan",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2016
    },
    "UkpxGhHE": {
        "id": "UkpxGhHE",
        "title": "The role of glutathione detoxification pathway in MCLR-induced hepatotoxicity in SD rats: Glutathione Detoxification Pathway of Microcystin-LR",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "liang chen",
                "org": ""
            },
            {
                "name": "cheng zeng",
                "org": ""
            },
            {
                "name": "dezhao yu",
                "org": ""
            },
            {
                "name": "huihui fan",
                "org": ""
            },
            {
                "name": "xiaochun guo",
                "org": ""
            },
            {
                "name": "ping xie",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "shangchun li",
                "org": ""
            }
        ],
        "venue": "Environmental Toxicology",
        "year": 2014
    },
    "l57x1rfa": {
        "id": "l57x1rfa",
        "title": "Effects of microcystin-LR on gut microflora in different gut regions of mice.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ping xie",
                "org": ""
            },
            {
                "name": "juan lin",
                "org": ""
            },
            {
                "name": "jun he",
                "org": ""
            },
            {
                "name": "cheng zeng",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            }
        ],
        "venue": "Journal of Toxicological Sciences",
        "year": 2015
    },
    "phO1KRnr": {
        "id": "phO1KRnr",
        "title": "Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish.",
        "abstract": "Frequencies and durations of blooms of cyanobacteria are increasing. Some cyanobacteria can produce cyanotoxins including microcystins (MCs). MCs are the most common toxic products of hazardous algal blooms (HABs), with the greatest potential for exposure and to cause toxicity. Recently, MCs have been shown to disrupt endocrine functions. In this study, for the first time, effects of MC-LR on the hypothalamic-pituitary-inter-renal (HPI) axis during early embryonic development (embryos/larvae) of zebrafish (Danio rerio), were investigated. Embryos/larvae of zebrafish were exposed to 1, 10, 100, or 300\u202f\u03bcg MC-LR/L during the period of 4-168\u202fh post-fertilization (hpf). Exposure to 300\u202f\u03bcg MC-LR/L resulted in significantly greater concentrations of whole-body cortisol than those in controls. Expressions of genes along the HPI axis and mineralocorticoid receptor (MR-) and glucocorticoid receptor (GR-) centered gene networks were evaluated by use of quantitative real-time PCR. Expression of mRNA for crh was significantly down-regulated by exposure to 300\u202f\u03bcg MC-LR/L, while expressions of crhbp, crhr1, and crhr2 were significantly up-regulated, relative to controls. MC-LR caused significantly lesser levels of mRNA for steroidogenic genes including hmgra, star, and cyp17, but expression of mRNA for hsd20b was significantly greater than that of controls. Treatment with MC-LR also altered profiles of transcription of MR- and GR-centered gene networks, which might result in multiple responses. Taken together, these results demonstrated that MC-LR affected the corticosteroid-endocrine system of larvae of zebrafish. This study provided valuable insights into molecular mechanisms behind potential toxicity and endocrine disruption of MCs.",
        "keywords": [
            "Cortisol",
            "Endocrine disruption",
            "Gene expression",
            "Hazardous algal blooms",
            "Steroids"
        ],
        "authors": [
            {
                "name": "Liang Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "Yeke Wang",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "John P Giesy",
                "org": "Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan S7N5B3, Canada."
            },
            {
                "name": "Feng Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "Ting Shi",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, China. Electronic address: xieping@ihb.ac.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "40Nyi6o3": {
        "id": "40Nyi6o3",
        "title": "A proteomic study on liver impairment in rat pups induced by maternal microcystin-LR exposure.",
        "abstract": "There is mounting evidence indicating that microcystins (MCs) are heptapeptide toxins. Recent studies have also shown that MCLR can transfer from mother to offspring, but it is unclear whether maternal MCLR can influence the liver of offspring or not. In this study, pregnant SD rats were injected intraperitoneally with a saline solution (control) or 10\u00a0\u03bcg/kg MCLR per day from gestational day 8 (GD8) to postnatal day 15 (PD15) for a total of 4 weeks. 2-DE and MALDI-TOF-TOF mass spectrometry were used to screen for MCLR target proteins in the livers of rat pups. Our results demonstrated that MCLR could accumulate in the livers of neonatal rats. Proteomics studies also showed that MCLR significantly influenced many proteins, including those involved in the cytoskeleton, metabolism and particularly oxidative stress. In addition, MCLR induced cellular structural damage and resulted in the production of intracellular reactive oxygen species (ROS) and lipid peroxidation. Moreover, protein phosphatase (PP) activity was inhibited and some serum biochemistry parameters were altered. These results suggest an early molecular mechanism behind the hepatotoxicity induced by maternal MC exposure and highlight the importance of monitoring MC concentrations in new-born mammals. ",
        "keywords": [
            "Liver",
            "MCLR",
            "Oxidative damage",
            "Proteomics",
            "Rat pups"
        ],
        "authors": [
            {
                "name": "Sujuan Zhao",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China. Electronic address: xieping@ihb.ac.cn."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            },
            {
                "name": "Luyi Liu",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            },
            {
                "name": "Huihui Fan",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, PR China."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2016
    },
    "ZyN0QtON": {
        "id": "ZyN0QtON",
        "title": "Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR",
        "abstract": "In this study, for the first time, changes in expressions of proteins and profiles of metabolites in liver of the small, freshwater fish Danio rerio (zebrafish) were investigated after long-term exposure to environmentally relevant concentrations of microcystin-LR (MC-LR). Male zebrafish were exposed via water to 1 or 10 \u03bcg MC-LR/L for 90 days, and iTRAQ-based proteomics and 1H NMR-based metabolomics were employed. Histopathological observations showed that MC-LR caused damage to liver, and the effects were more pronounced in fish exposed to 10 \u03bcg MC-LR/L. Metabolomic analysis also showed alterations of hepatic function, which included changes in a number of metabolic pathways, including small molecules involved in energy, glucose, lipids, and amino acids metabolism. Concentrations of lactate were significantly greater in individuals exposed to MC-LR than in unexposed controls. This indicated a shift toward anaerobic metabolism, which was confirmed by impaired respiration in mitochondria. Proteomics revea...",
        "keywords": "",
        "authors": [
            {
                "name": "Liang Chen",
                "org": ""
            },
            {
                "name": "Yufei Hu",
                "org": ""
            },
            {
                "name": "Jun He",
                "org": ""
            },
            {
                "name": "Jun Chen",
                "org": ""
            },
            {
                "name": "John P. Giesy",
                "org": ""
            },
            {
                "name": "Ping Xie",
                "org": ""
            }
        ],
        "venue": "Environmental Science & Technology",
        "year": 2017
    },
    "lxM9wOoQ": {
        "id": "lxM9wOoQ",
        "title": "In situ enclosure experiments on the occurrence, development and decline of black bloom and the dynamics of its associated taste and odor compounds",
        "abstract": "",
        "keywords": [
            "dissolved oxygen"
        ],
        "authors": [
            {
                "name": "dezhao yu",
                "org": ""
            },
            {
                "name": "ping xie",
                "org": ""
            },
            {
                "name": "cheng zeng",
                "org": ""
            },
            {
                "name": "lijuan xie",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            }
        ],
        "venue": "Ecological Engineering",
        "year": 2016
    },
    "AB7fQrwg": {
        "id": "AB7fQrwg",
        "title": "Metabolic Response to Oral Microcystin-LR Exposure in the Rat by NMR-Based Metabonomic Study",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guangyu li",
                "org": ""
            },
            {
                "name": "laiyan wu",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "jun he",
                "org": ""
            },
            {
                "name": "ping xie",
                "org": ""
            }
        ],
        "venue": "Journal of Proteome Research",
        "year": 2012
    },
    "fKidnB1I": {
        "id": "fKidnB1I",
        "title": "Prolonged exposure to low-dose microcystin induces nonalcoholic steatohepatitis in mice: a systems toxicology study.",
        "abstract": "Microcystin-LR (MCLR), a cyanotoxin widely present in freshwater, has been shown to have potent acute hepatotoxicity. However, the chronic toxicity of low-dose MCLR remains confusing by traditional measurements of toxicity. This has impeded understanding of the chronic liver damage of low-dose MCLR and corresponding safety risks of the human exposure guideline value. Here, iTRAQ-based proteomics and NMR-based metabonomics were used to decipher the molecular toxicological signatures of low doses of MCLR in mice exposed to this agent for 90\u00a0days. Low levels of MCLR, even under the reported no observed adverse effect level, significantly altered hepatic protein expression, especially of proteins associated with lipid metabolism, transport, immune and proteolysis. Coherently, MCLR induced marked perturbations in lipid metabolites in both liver and serum. Integrated analysis of proteomic, metabolic, histological and cytokine profiles revealed that MCLR significantly inhibited fatty acid \u03b2-oxidation and hepatic lipoprotein secretion and promoted hepatic inflammation, resulting in nonalcoholic steatohepatitis disease (NASH). These findings for the first time provide compelling evidence that chronic exposure to low-level MCLR can induce NASH. These results also indicate that current guidelines for MCs in drinking water may be inadequate and associated with risks to human health.",
        "keywords": [
            "Hepatotoxicity",
            "Metabonomics",
            "Microcystin-LR",
            "Nonalcoholic steatohepatitis",
            "Proteomics"
        ],
        "authors": [
            {
                "name": "Jun He",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan, 430072, People's Republic of China."
            },
            {
                "name": "Guangyu Li",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan, 430072, People's Republic of China."
            },
            {
                "name": "Juan Lin",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan, 430072, People's Republic of China."
            },
            {
                "name": "Cheng Zeng",
                "org": "College of Fisheries, Huazhong Agricultural University, Wuhan, 430070, People's Republic of China."
            },
            {
                "name": "Jing Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan, 430072, People's Republic of China."
            },
            {
                "name": "Junliang Deng",
                "org": "Shanghai Biotree Biotech Co., Ltd, Shanghai, 200433, People's Republic of China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan, 430072, People's Republic of China. xieping@ihb.ac.cn."
            }
        ],
        "venue": "Archives of toxicology",
        "year": 2017
    },
    "V2CC48A4": {
        "id": "V2CC48A4",
        "title": "Quantitative analysis of glutathione and cysteine S-conjugates of microcystin-LR in the liver, kidney and muscle of common carp (Cyprinus carpio) in Lake Taihu.",
        "abstract": "Tissue distribution of microcystin (MC)-LR-GSH, MC-LR-Cys and MC-LR of omnivorous fish in Lake Taihu was investigated. MC-LR and MC-LR-Cys were detected in liver, kidney and muscle. The concentration of MC-LR in liver and kidney was 0.052 \u03bcg g DW and 0.067 \u03bcg g DW, respectively. MC-LR-Cys appeared to be an important metabolite with average contents of 1.104 \u03bcg g DW and 0.724 \u03bcg g DW in liver and kidney, and the MC-LR-Cys/MC-LR ratio in liver and kidney reaching as high as 21.4 and 10.8. High MC-LR-Cys/MC-LR ratio and a significant correlation between MC-LR-Cys and MC-LR concentration in liver, suggest that liver is more active in detoxification of MC-LR by formation of MC-LR-Cys for omnivorous fish. Furthermore, there might be a balance between the accumulation and depuration/metabolism of MC-LR-Cys in kidney. The MC-LR-Cys can be formed in kidney directly, or transported from liver or other tissues, while the MC-LR-Cys in kidney might be dissociated to MC-LR or excreted. Although MC-LR and its metabolites were scarcely detected in muscle, it is necessary to investigate the distribution of toxic metabolites in edible muscle.",
        "keywords": "",
        "authors": [
            {
                "name": "Laiyan Wu",
                "org": "Key Laboratory of Catalysis and Materials Sciences of the State Ethnic Affairs Commission & Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074, China."
            },
            {
                "name": "Songbo Wang",
                "org": "Key Laboratory of Catalysis and Materials Sciences of the State Ethnic Affairs Commission & Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074, China."
            },
            {
                "name": "Min Tao",
                "org": "Life Sciences college of Neijiang Normal University, Neijiang 641000, China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, China E-mail: xieping@ihb.ac.cn."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu South Road 7, Wuhan 430072, China E-mail: xieping@ihb.ac.cn."
            }
        ],
        "venue": "Journal of water and health",
        "year": 2017
    },
    "eKCiiGQc": {
        "id": "eKCiiGQc",
        "title": "The role of GSH in microcystin-induced apoptosis in rat liver: Involvement of oxidative stress and NF-\u03baB: Microcystin-Induced Apoptosis in Rat Liver",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "liang chen",
                "org": ""
            },
            {
                "name": "shangchun li",
                "org": ""
            },
            {
                "name": "xiaochun guo",
                "org": ""
            },
            {
                "name": "ping xie",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            }
        ],
        "venue": "Environmental Toxicology",
        "year": 2014
    },
    "S8yLk6ff": {
        "id": "S8yLk6ff",
        "title": "Experimental evidence for the role of heterotrophic bacteria in the formation of Microcystis colonies",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wenjing wang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "hong shen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "pengling shi",
                "org": "huazhong agricultural university"
            },
            {
                "name": "jun chen",
                "org": "chinese academy of sciences"
            },
            {
                "name": "leyi ni",
                "org": "chinese academy of sciences"
            },
            {
                "name": "ping xie",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Journal of Applied Phycology",
        "year": 2015
    },
    "ui8RYDXH": {
        "id": "ui8RYDXH",
        "title": "Systematic identification of seven ribosomal protein genes in bighead carp and their expression in response to microcystin-LR",
        "abstract": "Microcystin-LR (MCLR) is one of the most toxic cyanotoxins produced in algal blooms. The toxic effects of MCLR on the expression of some organelles genes (mitochondrion, endoplasmic reticulum, and cytoskeleton etc) have been widely investigated, but little is known how it impacts on the expression of ribosomal genes. In this study we identified seven ribosomal protein genes RPS6, RPS12, RPS24, RPS27a, RPL12, RPL27 and RPL29 in bighead carp (Aristichthys nobilis), whose expression was regulated by MCLR. The amino acid sequences of those 7 genes shared more than 90% identity with corresponding sequences from zebrafish, and were well conserved throughout evolution. The 3D structure prediction showed that the structures of these ribosomal proteins were conserved, but had species specificity. Q-PCR analysis revealed that expression of seven genes changed dramatically at 3 hr, then went back to a moderate change-level at 24 hr in almost all tested tissues (liver, kidney, intestine, heart, spleen and gill) post MCLR injection, but in brain expression of the seven genes stayed same as the normal level. This study will help us to know not only about the evolution and functions of ribosomal proteins in anti-MCLR response in bighead carp, but also about the MCLR toxicity and its impact on aquaculture and human health.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan Cai",
                "org": "School of Petrolchemical Engneering, Changzhou University, China"
            },
            {
                "name": "Chao Zhang",
                "org": "School of Petrolchemical Engneering, Changzhou University, China"
            },
            {
                "name": "Le Hao",
                "org": "Guangdong Public Laboratory of Veterinary Public Health, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, China"
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, China"
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, Chinese Academy of Sciences, China"
            },
            {
                "name": "Zhidong Chen",
                "org": "School of Petrolchemical Engneering, Changzhou University, China"
            }
        ],
        "venue": "Journal of Toxicological Sciences",
        "year": 2016
    },
    "zMfI3oqh": {
        "id": "zMfI3oqh",
        "title": "Microcystin-LR affects the hypothalamic-pituitary-inter-renal (HPI) axis in early life stages (embryos and larvae) of zebrafish.",
        "abstract": "Frequencies and durations of blooms of cyanobacteria are increasing. Some cyanobacteria can produce cyanotoxins including microcystins (MCs). MCs are the most common toxic products of hazardous algal blooms (HABs), with the greatest potential for exposure and to cause toxicity. Recently, MCs have been shown to disrupt endocrine functions. In this study, for the first time, effects of MC-LR on the hypothalamic-pituitary-inter-renal (HPI) axis during early embryonic development (embryos/larvae) of zebrafish (Danio rerio), were investigated. Embryos/larvae of zebrafish were exposed to 1, 10, 100, or 300\u202f\u03bcg MC-LR/L during the period of 4-168\u202fh post-fertilization (hpf). Exposure to 300\u202f\u03bcg MC-LR/L resulted in significantly greater concentrations of whole-body cortisol than those in controls. Expressions of genes along the HPI axis and mineralocorticoid receptor (MR-) and glucocorticoid receptor (GR-) centered gene networks were evaluated by use of quantitative real-time PCR. Expression of mRNA for crh was significantly down-regulated by exposure to 300\u202f\u03bcg MC-LR/L, while expressions of crhbp, crhr1, and crhr2 were significantly up-regulated, relative to controls. MC-LR caused significantly lesser levels of mRNA for steroidogenic genes including hmgra, star, and cyp17, but expression of mRNA for hsd20b was significantly greater than that of controls. Treatment with MC-LR also altered profiles of transcription of MR- and GR-centered gene networks, which might result in multiple responses. Taken together, these results demonstrated that MC-LR affected the corticosteroid-endocrine system of larvae of zebrafish. This study provided valuable insights into molecular mechanisms behind potential toxicity and endocrine disruption of MCs.",
        "keywords": [
            "Cortisol",
            "Endocrine disruption",
            "Gene expression",
            "Hazardous algal blooms",
            "Steroids"
        ],
        "authors": [
            {
                "name": "Liang Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "Yeke Wang",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "John P Giesy",
                "org": "Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan S7N5B3, Canada."
            },
            {
                "name": "Feng Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "Ting Shi",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; University of Chinese Academy of Sciences, Beijing, 100049, China."
            },
            {
                "name": "Jun Chen",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China."
            },
            {
                "name": "Ping Xie",
                "org": "Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China; State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, 810016, China. Electronic address: xieping@ihb.ac.cn."
            }
        ],
        "venue": "Environmental pollution (Barking, Essex : 1987)",
        "year": 2018
    },
    "GkWHuiaZ": {
        "id": "GkWHuiaZ",
        "title": "Identification of Serine 119 as an Effective Inhibitor Binding Site of M. tuberculosis Ubiquitin-like Protein Ligase PafA Using Purified Proteins and M. smegmatis.",
        "abstract": "Owing to the spread of multidrug resistance (MDR) and extensive drug resistance (XDR), there is a pressing need to identify potential targets for the development of more-effective anti-M. tuberculosis (Mtb) drugs. PafA, as the sole Prokaryotic Ubiquitin-like Protein ligase in the Pup-proteasome System (PPS) of Mtb, is an attractive drug target. Here, we show that the activity of purified Mtb PafA is significantly inhibited upon the association of AEBSF (4-(2-aminoethyl) benzenesulfonyl fluoride) to PafA residue Serine 119 (S119). Mutation of S119 to amino acids that resemble AEBSF has similar inhibitory effects on the activity of purified Mtb PafA. Structural analysis reveals that although S119 is distant from the PafA catalytic site, it is located at a critical position in the groove where PafA binds the C-terminal region of Pup. Phenotypic studies demonstrate that S119 plays critical roles in the function of Mtb PafA when tested in M. smegmatis. Our study suggests that targeting S119 is a promising direction for developing an inhibitor of M. tuberculosis PafA.",
        "keywords": [
            "4-(2-aminoethyl) benzenesulfonyl fluoride",
            "M. Tuberculosis",
            "PafA",
            "Pupylation"
        ],
        "authors": [
            {
                "name": "He-Wei Jiang",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Daniel M Czajkowsky",
                "org": "School of Biomedical Engineering, Bio-ID Center, Shanghai Jiao Tong University, Shanghai 200240, China; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Tao Wang",
                "org": "Department of Biology, Southern University of Science and Technology, Shenzhen 518055, China; SZCDC-SUSTech Joint Key Laboratory for Tropical Diseases, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China."
            },
            {
                "name": "Xu-De Wang",
                "org": "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China."
            },
            {
                "name": "Jia-Bin Wang",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Hai-Nan Zhang",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Cheng-Xi Liu",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Fan-Lin Wu",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Xiang He",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Zhao-Wei Xu",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Hong Chen",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Shu-Juan Guo",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Yang Li",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China."
            },
            {
                "name": "Li-Jun Bi",
                "org": "National Key Laboratory of Biomacromolecules, Key Laboratory of Non-Coding RNA and Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; TB Healthcare Biotechnology Co., Ltd., Foshan, Guangdong 528000, China; School of Stomatology and Medicine, Foshan University, Foshan 528000, Guangdong Province, China."
            },
            {
                "name": "Jiao-Yu Deng",
                "org": "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China."
            },
            {
                "name": "Jin Xie",
                "org": "Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China."
            },
            {
                "name": "Jian-Feng Pei",
                "org": "Center for Quantitative Biology, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China."
            },
            {
                "name": "Xian-En Zhang",
                "org": "National Key Laboratory of Biomacromolecules, Key Laboratory of Non-Coding RNA and Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China."
            },
            {
                "name": "Sheng-Ce Tao",
                "org": "Shanghai Center for Systems Biomedicine, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200240, China; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address: taosc@sjtu.edu.cn."
            }
        ],
        "venue": "EBioMedicine",
        "year": 2018
    },
    "0lQzPVyR": {
        "id": "0lQzPVyR",
        "title": "An ALN two-dimensional acoustic wave humidity sensor with graphene oxide as sensing layer",
        "abstract": "In this paper, we firstly report an AlN thin film two-dimensional acoustic wave humidity sensor with graphene oxide (GO) as sensing layer. The sensor with small sensing area show high sensitivity up to 218.6 kHz/10%RH with a wide detection range from 10% to 90%RH. The sensor has excellent performance in terms of repeatability and stability. Little hysteresis, fast response and short recovery time of the sensors are obtained. The TCF of the sensor is about \u221215.8 ppm/\u00b0C, much smaller than conventional humidity sensors.",
        "keywords": "",
        "authors": [
            {
                "name": "Xianhao Le",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "international conference on micro electro mechanical systems",
        "year": 2017
    },
    "X4w7hgSf": {
        "id": "X4w7hgSf",
        "title": "An AlN Based SAW Device for Detection of Impurities in Water Based on Measuring the Signal-to-Noise Ratio",
        "abstract": "Water quality monitoring is a critical part of environmental management and protection. The detection of contamination and impurity levels in water is of importance for the protection of public health. In this paper, we present a novel method for detection of impurities in water based on measuring the signal-to-noise ratio (SNR) of the surface acoustic wave (SAW) device. An aluminum nitride (AIN) based SAW device is fabricated for residues detection. NaCl and SiO 2  are regarded as water-soluble and water-insoluble impurities in water respectively. The experimental results show that the SAW propagation surfaces are cleaner after evaporation of different kinds of water samples, which then result in higher SNRs. Nevertheless, for different mass concentrations of NaCl and SiO 2  droplets, the SNRs of the SAW device are lower due to more residues left on the wave propagation path after evaporation.",
        "keywords": "",
        "authors": [
            {
                "name": "Yong Wang",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Dongyang Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Weixin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Xuying Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Xinxin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "eIBC1ltE": {
        "id": "eIBC1ltE",
        "title": "Piezoelectric and electromagnetic hybrid energy harvester for powering wireless sensor nodes in smart grid",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wang chen",
                "org": "zhejiang university"
            },
            {
                "name": "yanlong cao",
                "org": "zhejiang university"
            },
            {
                "name": "jin xie",
                "org": "zhejiang university"
            }
        ],
        "venue": "Journal of Mechanical Science and Technology",
        "year": 2015
    },
    "9NUjOJ5d": {
        "id": "9NUjOJ5d",
        "title": "Distilling determination of water content in hydraulic oil with a ZnO/glass surface acoustic wave device",
        "abstract": "Detection of water content in hydraulic oil is critical to identify abnormal wear conditions for purpose of predicting possible machinery failure in hydraulic systems. The paper reports a feasibility study of measuring the water content in the hydraulic oil using a ZnO thin film surface acoustic wave (SAW) device combined with the standard distillation method. The shift of resonant frequency of the SAW device increases with the increase of water content in hydraulic oil, and reaches 919 kHz for 0.80 wt% water content in oil samples. The results indicate that the ZnO SAW sensor can detect water content in hydraulic oil with high sensitivity.",
        "keywords": "",
        "authors": [
            {
                "name": "Zebing Mao",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Jiuxuan Zhao",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Weipeng Xuan",
                "org": "Department of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Wenbo Wang",
                "org": "Department of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Jikui Luo",
                "org": "Department of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, People's Republic of China 310027 and Institution of Renewable Energy and Environmental Technologies, U ..."
            },
            {
                "name": "Jin Xie",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, People's Republic of China 310027"
            }
        ],
        "venue": "Microsystem Technologies",
        "year": 2017
    },
    "N9EglqNs": {
        "id": "N9EglqNs",
        "title": "A humidity sensor with high sensitivity and low temperature coefficient of frequency based on aln surface acoustic wave and graphene oxide sensing layer",
        "abstract": "This paper reports a humidity sensor based on AlN surface acoustic wave (SAW) device coated with graphene oxide (GO) as sensing layer. Utilizing a layered structure consisted of a thin AlN layer and a highly doped Si substrate layer, the temperature coefficient of frequency (TCF) of the sensor is found to be around \u221222.1 ppm/\u00b0C, much smaller than conventional SAW humidity sensors. Moreover, the sensor has a wide detection range from 5% to 95%RH and shows high sensitivity up to 420.8 kHz/10%RH at 90%RH. Little hysteresis, excellent repeatability, fast response and short recovery time of the sensor are obtained. The sensor also has a good stability in a period of 28 days.",
        "keywords": "",
        "authors": [
            {
                "name": "Xianhao Le",
                "org": ""
            },
            {
                "name": "Hong Ding",
                "org": "<org_name>State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310027, People's Republic of China</org_name>"
            },
            {
                "name": "Jintao Pang",
                "org": "<org_name>State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310027, People's Republic of China</org_name>"
            },
            {
                "name": "Yixiang Wang",
                "org": "<org_name>State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310027, People's Republic of China</org_name>"
            },
            {
                "name": "Jin Xie",
                "org": "<org_name>State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310027, People's Republic of China</org_name>"
            }
        ],
        "venue": "international conference on solid state sensors actuators and microsystems",
        "year": 2017
    },
    "MHnqHsjd": {
        "id": "MHnqHsjd",
        "title": "Electrostatic charge sensor based on a micromachined resonator with dual micro-levers",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jiuxuan zhao",
                "org": ""
            },
            {
                "name": "hong ding",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2015
    },
    "Dkgw5tFB": {
        "id": "Dkgw5tFB",
        "title": "Optimization of pMUTs Driving Waveform Based on Phase Delay to Reduce Attenuation Vibration",
        "abstract": "This paper proposes optimization of driving waveform for piezoelectric micromachined ultrasonic transducers (pMUTs) based on phase delay method. The optimized driving form can effectively improve emission efficiency and shorten the blind, which directly indicates shortened blind area in pulse-echo ultrasonic distance measurement. The phase delay method effectively restrains the pMUTu0027s attenuation vibration within 20 nm in air and 15 nm in water swiftly. This method can save attenuation time varying from 45.9~206 \u03bcs in air and 78.9~130.1 \u03bcs in water respectively. When applied in ultrasonic range-finders, this method can shorten the blind area by 35 mm in air and 97.6 mm in water respectively. Furthermore, in some particular circumstance where less pulses are preferred as excitation, the ratio of emission time to vibration time can be greatly improved in high Q factor transducer, then enhance the emission efficiency.",
        "keywords": "",
        "authors": [
            {
                "name": "Xinxin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Xuying Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Zhonggui Xu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Changju Wu",
                "org": "Zhejiang University, School of Aeronautics and Astronautics, China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "PoaQMWXX": {
        "id": "PoaQMWXX",
        "title": "Analytical study and compensation for temperature drifts of a bulk silicon MEMS capacitive accelerometer",
        "abstract": "Abstract   An analytical study and a compensation structure for temperature drifts of bias and scale factor of a bulk silicon MEMS capacitive accelerometer are presented. The analytical model for the temperature drift of bias (TDB) and temperature drift of scale factor (TDSF) is established based on the analysis results of thermal deformation and stiffness temperature dependence. The model shows that TDB is only caused by thermal deformation, while TDSF consists of two parts caused by stiffness temperature dependence and thermal deformation, respectively. The two parts are positive and negative, respectively, but the second part has greater absolute value. First part of TDSF can be reduced by high doping. TDB and second part of TDSF can be both reduced by soft adhesive die attaching or increasing substrate thickness. In silicon structure, TDB can be reduced by middle-locating anchors for moving electrodes in sensitive direction or decreasing the stiffness asymmetry of springs, while second part of TDSF can be reduced by middle-locating anchors for fixed electrodes in sensitive direction. By middle-locating anchors both for moving electrodes and fixed electrodes, a temperature compensation structure is designed to reduce TDB and second part of TDSF. Consequently, TDSF is reduced by making the two parts of TDSF cancel each other. Experimental results show that TDB is suppressed from 1.85\u00a0mg/\u00b0C to 0.52\u00a0mg/\u00b0C, while TDSF from \u2212162.7\u00a0ppm/\u00b0C to \u221250.8\u00a0ppm/\u00b0C.",
        "keywords": "",
        "authors": [
            {
                "name": "Jiangbo He",
                "org": "School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, China"
            },
            {
                "name": "Jin Xie",
                "org": "School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, China"
            },
            {
                "name": "Xiaoping He",
                "org": "Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang 621900, China"
            },
            {
                "name": "Lianming Du",
                "org": "Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang 621900, China"
            },
            {
                "name": "Wu Zhou",
                "org": "University of Electronic Science and Technology of China, Chengdu 611731, China"
            }
        ],
        "venue": "Sensors and Actuators A-physical",
        "year": 2016
    },
    "XpBIROCW": {
        "id": "XpBIROCW",
        "title": "A Miniature System for Classification and Concentration Detection of PM Based on 3D Printed Virtual Impactor and QCM Sensor",
        "abstract": "In this paper, we report a miniature system for separation and concentration detection of airborne particulate matter (PM) based on three-dimensional (3D) printed virtual impactor and quartz crystal microbalance (QCM) sensor. The virtual impactor is optimized by computational fluid dynamics (CFD) simulation to have a relatively small size of $mathbf{24} times mathbf{24}times mathbf{10} mathbf{mm}^{3}$. The performance of the miniature PM monitoring system is characterized through classification and detection of silicon oxide powers with diameter ranging from 0.5 to $mathbf{10}mu mathbf{m}$ in a chamber. The experimental results show that particles smaller than cutoff diameter of $mathbf{2.5} mu mathbf{m}$ are separated by the virtual impactor according to their size and detected by the QCM sensor. Moreover, the resonant frequency of the QCM sensor shows a linear decrease with the increment of PM mass loading.",
        "keywords": "",
        "authors": [
            {
                "name": "Yong Wang",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Yinshen Wang",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Weixin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Dongyang Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Changju Wu",
                "org": "Zhejiang University, School of Aeronautics and Astronautics, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "7gCOP8m4": {
        "id": "7gCOP8m4",
        "title": "A Novel Humidity Sensor Based on Circular Interdigital Transducers Excited ALN Lamb Wave Device Incorporating Graphene Oxide Layer",
        "abstract": "In this paper, a circular interdigital transducers (IDTs) excited lamb wave humidity sensor with graphene oxide (GO) as sensing layer is firstly reported. The circular IDTs are adopted to deal with lamb wave diffraction problem due to finite aperture of conventional straight IDTs. Test results show the humidity sensitivity of the circular IDTs excited sensor is 1.5 times higher than that of conventional straight IDTs excited sensor within a wide detection range from 10 % RH to 90%RH. In addition to excellent stability and repeatability, the sensor also has very little hysteresis, fast response and quick recovery speed. Moreover, utilizing the AlN/Si (doped) layered structure, small temperature coefficient of frequency (TCF) of \u221219.8 ppm/\u00b0C of the sensor is achieved.",
        "keywords": "",
        "authors": [
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, People's Republic of China"
            },
            {
                "name": "Jintao Pang",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, People's Republic of China"
            },
            {
                "name": "Dongsheng Li",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, People's Republic of China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "OXD3pyZm": {
        "id": "OXD3pyZm",
        "title": "A High-Performance Square pMUT for Range-finder",
        "abstract": "A rangefinder based on an AIN piezoelectric micromachined ultrasound transducer (pMUT) is presented to localize targets up to 10 cm using pulse-echo (PE) mode. An experimental set-up has been described and implemented to characterize two kinds of pMUTs: square pMUT and circular pMUT. Compared to the traditional circular pMUT with top electrode laying on the center part, the square pMUT with outer frame-like electrode shows better performance in receiving ultrasonic waves. Working at the same frequency, the square pMUT saves 11.2% area and can achieve higher fill factor in array. Both pMUTs are tested at the frequency of 400 kHz in air.",
        "keywords": "",
        "authors": [
            {
                "name": "Xinxin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Xuying Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Zhonggui Xu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Changju Wu",
                "org": "Zhejiang University, School of Aeronautics and Astronautics, China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "HCqDn8uU": {
        "id": "HCqDn8uU",
        "title": "Mutual cancellation phenomenon of the nonlinearities in micro-machined double-clamped beams resonator",
        "abstract": "In this work, a cancellation phenomenon between mechanical and electrical nonlinearities has been observed in a parallel-plate driven double ended tuning forks (DETF) resonator, which is used to reduce overall nonlinearity in the premise of operational restriction on the excitation conditions. An improved method has been proposed to cancel the inherent nonlinearity by introducing additional nonlinearity with inside tuning capacitors on the comb drive DETF resonator. The improved method makes the reduction tunable meanwhile alleviates the discontinuity of the frequency spectrum to enhance frequency stability and quality factor. The cancellation can partially eliminate the nonlinearities that contribute to a wider linear regime and higher power handling of the resonator.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongyang Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, China"
            },
            {
                "name": "Xuyin Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, China"
            },
            {
                "name": "Yangyang Guan",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, China"
            },
            {
                "name": "Yong Wang",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, China"
            },
            {
                "name": "Zhonggui Xu",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, China"
            },
            {
                "name": "Yinshen Wang",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, China"
            },
            {
                "name": "Hongyun Lin",
                "org": "School of Mechanical and Electric Engineering, Jiangsu Provincial Key Laboratory of Advanced Robotics, Soochow University, China"
            },
            {
                "name": "Huicong Liu",
                "org": "School of Mechanical and Electric Engineering, Jiangsu Provincial Key Laboratory of Advanced Robotics, Soochow University, China"
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "international conference on micro electro mechanical systems",
        "year": 2018
    },
    "6rwulS9N": {
        "id": "6rwulS9N",
        "title": "Airborne Particulate Matter Classification and Concentration Detection Based on 3D Printed Virtual Impactor and Quartz Crystal Microbalance Sensor",
        "abstract": "Abstract   In this paper, design, fabrication and experiment of a miniature system for detection of airborne particulate matter (PM) are presented. The miniature system contains a virtual impactor and a quartz crystal microbalance (QCM) resonant sensor. The virtual impactor is fabricated by three-dimensional (3D) printing process for classifying airborne particles according to their size. The QCM resonant sensor is utilized to detect the mass of the separated particles from the virtual impactor. The design of virtual impactor is optimized by computational fluid dynamics simulation and the QCM for its resonance in thickness shear mode is analyzed by finite element method. Silicon dioxide powders with diameter in the range from 0.5 to 8\u00a0\u03bcm are successfully separated according to their size by the virtual impactor, which indicates that the classification characteristic coincides with the theoretical and simulation results. PM concentration in a chamber is measured by the proposed monitoring system and the experimental results show that the resonant frequency of the QCM turns downward linearly with the PM mass loading increasing.",
        "keywords": [
            "quartz crystal microbalance",
            "3d printing"
        ],
        "authors": [
            {
                "name": "jiuxuan zhao",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, PR China"
            },
            {
                "name": "minliang liu",
                "org": ""
            },
            {
                "name": "liang liang",
                "org": ""
            },
            {
                "name": "wen wang",
                "org": "School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, PR China"
            },
            {
                "name": "jin xie",
                "org": ""
            }
        ],
        "venue": "Sensors and Actuators A-physical",
        "year": 2016
    },
    "kd99JUDi": {
        "id": "kd99JUDi",
        "title": "A MEMS Fishbone-Shaped Electrostatic Double-Ended Tuning Fork Resonator With Selectable Higher Modes",
        "abstract": "In this paper, a microelectromechanical systems fishbone-shaped electrostatic double-ended tuning fork (DETF) resonator with selectable higher modes is presented. The resonator can realize ten vibration modes with resonant frequencies from 137.929 to 913.476 kHz and multi-mode selection function. Different from conventional electrostatic actuation methods, the proposed fishbone-shaped structure combined with tooth-shaped electrode generates bending moment on the beam and leads to vibration of the DETF. The vibration mode and the resonant frequency can be selected and measured according to the configuration of electrodes. Consequently, the proposed fishbone-shaped DETF resonator can provide multi-mode vibration and variable resonant frequency. The device is fabricated by the silicon-on-insulator process and tested via open-loop spectral response measurement. Finally, electrical parameters of the equivalent circuit model are extracted for further research. [2016-0315]",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Ding",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Xianhao Le",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "IEEE\\/ASME Journal of Microelectromechanical Systems",
        "year": 2017
    },
    "Te9zNDOG": {
        "id": "Te9zNDOG",
        "title": "A Novel Electrode Design in DETF with Reducing Multimode Effect",
        "abstract": "This paper presents a new strategy of electrode design of aluminum nitride (AIN) double-ended tuning forks (DTEF) resonator. The new design makes actuation and sensing on both sides (dual driving) other than only one side (single driving) of the neutral line of the resonating beam, improving the performance of DETF resonator. There are three different resonate modes close in frequency. With this dual driving capability, the DETF is excited to vibrate more closely to in-plane resonant mode for which has less anchor loss and balanced stress distribution. The dual driving device does not change the resonant frequency and controls the out-of-plane displacement at an average value of 72.68 %, with indifferent change in in-plane displacement.",
        "keywords": "",
        "authors": [
            {
                "name": "Xinxin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Yixiang Wang",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Zhonggui Xu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "YHgKpxNi": {
        "id": "YHgKpxNi",
        "title": "An approach for transforming GMECs for a class of Petri nets with uncontrollable transitions",
        "abstract": "This paper addresses the problems of transforming a given generalized mutual exclusion constraint (GMEC) into an optimal admissible one. The considered class of Petri nets is such that the uncontrollable influence subnet is forward synchronization and forward conflict free (FSFCF) net. The difficulty of the solution to the transformation problems is to consider the situation where a transition may have more than one output place. Thus, the concept of pu0027s branches is introduced to analyze the properties of the net. Based on the properties, an approach is proposed to enforce the transformation equivalently. Compared with the reported methods, the proposed approach has higher computational efficiency. An example is provided to illustrate the transformation approach.",
        "keywords": "",
        "authors": [
            {
                "name": "Jin Xie",
                "org": "The State Key Laboratory of Industrial Control Technology and Institute of Cyber-systems and Control, Zhejiang University, Hangzhou 310027, China"
            },
            {
                "name": "Weimin Wu",
                "org": "The State Key Laboratory of Industrial Control Technology and Institute of Cyber-systems and Control, Zhejiang University, Hangzhou 310027, China"
            }
        ],
        "venue": "chinese control conference",
        "year": 2016
    },
    "Wp3fWPIU": {
        "id": "Wp3fWPIU",
        "title": "A new analytical model of single-stage microleverage mechanism in resonant accelerometer",
        "abstract": "Microleverage mechanism which is widely applied in microelectromechanical systems (MEMS) transfers and amplifies force or displacement from input to output. In this work, one-stage microleverage mechanism is integrated into a biaxial micro resonant accelerometer to improve sensitivity. Force amplification factor of the microleverage is analyzed and deduced by integral method. The results from theoretical model match well with the ones from finite element method (FEM) simulation, which proves that the proposed model is relatively accurate and the width of lever beam is a quite important parameter in design. The resonant accelerometer is successfully fabricated by MEMS technology. Preliminary experiments are conducted and demonstrate differential sensitivity of 71 Hz/g for the accelerometer with resonant frequency of 267.726 kHz.",
        "keywords": [
            "Output System",
            "Amplification Factor",
            "Proof Mass",
            "Finite Element Method Simulation",
            "Rotational Stiffness"
        ],
        "authors": [
            {
                "name": "hong ding",
                "org": "zhejiang university"
            },
            {
                "name": "jiuxuan zhao",
                "org": "zhejiang university"
            },
            {
                "name": "bingfeng ju",
                "org": "zhejiang university"
            },
            {
                "name": "jin xie",
                "org": "zhejiang university"
            }
        ],
        "venue": "Microsystem Technologies",
        "year": 2015
    },
    "ZhnfZ1Cz": {
        "id": "ZhnfZ1Cz",
        "title": "Reducing ring-down time of pMUTs with phase shift of driving waveform",
        "abstract": "Abstract   This paper proposes a method to reduce ring-down time for piezoelectric micromachined ultrasonic transducers (pMUTs) through phase shift. The proposed driving form can effectively improve the effective emission time to transmitting time (Tx time) ratio and decrease the ring-down time, which contributes to shorten the blind area in pulse-echo ultrasonic distance measurement. The phase shift method effectively restrains the pMUT\u2019s ring-down vibration within 20 nm in air and 15 nm in water swiftly. Consequently, the ring-down time can be saved from 45.9\u223c206 \u03bcs in air and 78.9\u223c130.1 \u03bcs in water respectively. The suppressed ring-down can sharpen the echo envelop for better location applications. Detection of the precise vibration stop time based on time constant of pMUTs is useful for measurement with high accuracy.",
        "keywords": "",
        "authors": [
            {
                "name": "X. Q. Liu",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "X. M. Chen",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Xianhao Le",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Yong Wang",
                "org": ""
            },
            {
                "name": "Changju Wu",
                "org": "School of Aeronautics and Astronautics, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Jin Xie",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            }
        ],
        "venue": "Sensors and Actuators A-physical",
        "year": 2018
    },
    "dncIVwAo": {
        "id": "dncIVwAo",
        "title": "Designing an efficient multimode environmental sensor based on graphene-silicon heterojunction",
        "abstract": "By exploiting the adsorbent gaseous molecules induced changes in intrinsic properties of graphene/silicon (Gr/Si) Schottky junction, the authors report a sensitive, low-power consuming, multimode environmental sensor. By combining an array of Gr/Si Schottky diodes with a differential amplifier circuit, the authors are able to not only differentiate the temperature coefficient and humidity sensing, but also monitor the sun-light exposure time. Our device is particularly sensitive toward humidity in both forward and reverse biased, and works in resistive as well as capacitive mode. Sensitivity of our devices reached to 17%, 45%, 26%, and 32% per relative humidity (%RH) for reverse biased, forward biased, resistive, and capacitive modes, respectively. In the reverse mode, the power consumption is as low as 2 nW. Moreover, our sensor response is highly selective, with sensitivity lower than 1% for other gases present in atmosphere including H2, O2, N2, and CO2. High sensitivity, low-power consumption, multiple operation modes, and high selectivity promises application of our sensor for industrial and home safety, environmental monitoring such as indoor and outdoor air conditions, process monitoring, and others.",
        "keywords": "",
        "authors": [
            {
                "name": "Khurram Shehzad",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Tianjin Shi",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Akeel Qadir",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Xia Wan",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Hongwei Guo",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Ayaz Ali",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Weipeng Xuan",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Hua Xu",
                "org": "State Key Laboratory of Bioelectronics; Southeast University; 210096 Nanjing China"
            },
            {
                "name": "Zhongze Gu",
                "org": "State Key Laboratory of Bioelectronics; Southeast University; 210096 Nanjing China"
            },
            {
                "name": "Xinsheng Peng",
                "org": "College of Material Science; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Jin Xie",
                "org": "State Key Laboratory of Fluid Power & Mechatronic systems; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Litao Sun",
                "org": "SEU-FEI Nano-Pico Center; Key Laboratory of MEMS of the Ministry of Education; Southeast University; Nanjing 210096 China"
            },
            {
                "name": "Qiyuan He",
                "org": "Department of Chemistry and Biochemistry; University of California; Los Angeles CA 90095 USA"
            },
            {
                "name": "Zhen Xu",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Chao Gao",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "You-Seung Rim",
                "org": "School of Intelligent Mechatronic Engineering; Sejong University; 209 Neungdong-ro Gwangjin-gu Seoul 05006 Republic of Korea"
            },
            {
                "name": "Yaping Dan",
                "org": "Joint Institute of University of Michigan and Shanghai Jiaotong University; 200240 Shanghai China"
            },
            {
                "name": "Tawfique Hasan",
                "org": "Cambridge Graphene Centre; University of Cambridge; Cambridge CB3 0FA UK"
            },
            {
                "name": "Pingheng Tan",
                "org": "State Key Laboratory of Superlattices and Microstructures; Institute of Semiconductors; Chinese Academy of Sciences; Beijing 100083 China"
            },
            {
                "name": "Erping Li",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Wenyan Yin",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Zhiyuan Cheng",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Bin Yu",
                "org": "College of Nanoscale Science and Engineering; State University of New York; NY 12203 USA"
            },
            {
                "name": "Yang Xu",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province; College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials; Zhejiang University; Hangzhou 310027 China"
            },
            {
                "name": "Jikui Luo",
                "org": "Institute of Renewable Energy & Environment Technologies; University of Bolton; Bolton BL3 5AB UK"
            },
            {
                "name": "Xiangfeng Duan",
                "org": "Department of Chemistry and Biochemistry; University of California; Los Angeles CA 90095 USA"
            }
        ],
        "venue": "Advanced materials and technologies",
        "year": 2017
    },
    "qh95Ccli": {
        "id": "qh95Ccli",
        "title": "An Impact-Based Frequency Up-Converting Hybrid Vibration Energy Harvester for Low Frequency Application",
        "abstract": "In this paper, a novel impact-based frequency up-converting hybrid energy harvester (FUCHEH) was proposed. It consisted of a piezoelectric cantilever beam and a driving beam with a magnetic tip mass. A solenoid coil was attached at the end of the piezoelectric beam. This innovative configuration amplified the relative motion velocity between magnet and coil, resulting in an enhancement of the induced electromotive force in the coil. An electromechanical coupling model was developed and a numerical simulation was performed to study the principle of impact-based frequency up-converting. A prototype was fabricated and experimentally tested. The time-domain and frequency-domain analyses were performed. Fast Fourier transform (FFT) analysis verified that fundamental frequencies and coupled vibration frequency contributes most of the output voltage. The measured maximum output power was 769.13 \u00b5W at a frequency of 13 Hz and an acceleration amplitude of 1 m/s2, which was 3249.4%- and 100.6%-times larger than that of the frequency up-converting piezoelectric energy harvesters (FUCPEH) and frequency up-converting electromagnetic energy harvester (FUCEMEH), respectively. The root mean square (RMS) voltage of the piezoelectric energy harvester subsystem (0.919 V) was more than 16 times of that of the stand-alone PEH (0.055 V). This paper provided a new scheme to improve generating performance of the vibration energy harvester with high resonant frequency working in the low-frequency vibration environment.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhenlong Xu",
                "org": ""
            },
            {
                "name": "Wen Wang",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            },
            {
                "name": "Zhonggui Xu",
                "org": ""
            },
            {
                "name": "Maoying Zhou",
                "org": ""
            },
            {
                "name": "Hong Yang",
                "org": ""
            }
        ],
        "venue": "Energies",
        "year": 2017
    },
    "3BSz6wIe": {
        "id": "3BSz6wIe",
        "title": "A high-sensitivity biaxial resonant accelerometer with two-stage microleverage mechanisms",
        "abstract": "This paper presents a design and experimental evaluation of a micro-electro-mechanical system biaxial resonant accelerometer with two-stage microleverage mechanisms. The device incorporates two pairs of double-ended tuning fork resonators coupled to a single proof mass. The two-stage microleverage mechanisms possess a higher amplification factor than single-stage microleverage mechanisms, so that the proposed accelerometer has a high level of sensitivity. In addition, a low level of cross-axis sensitivity is realized because of the decoupling beams. The accelerometer is theoretically analyzed and then simulated in the system level by the finite element method. The device is fabricated in a silicon-on-insulator wafer. The experimental results demonstrate that the average differential sensitivity of the resonant accelerometer is 275 Hz g?1 at a resonant frequency of 290?kHz under a polarization voltage of 5?V. The measured cross-axis sensitivity is lower than 3.4%.",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Ding",
                "org": ""
            },
            {
                "name": "Jiuxuan Zhao",
                "org": ""
            },
            {
                "name": "Bing-Feng Ju",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "Journal of Micromechanics and Microengineering",
        "year": 2016
    },
    "yg52gxWB": {
        "id": "yg52gxWB",
        "title": "Mechanical nonlinearity elimination with a micromechanical clamped-free semicircular beams resonator",
        "abstract": "This paper reports a micro-machined clamped-free semicircular beam resonator aiming to eliminate the nonlinearity that widely exists in traditional mechanical resonators. Cubic coefficients over vibration displacement due to axial extension of the beams are analyzed through theoretical modelling, and the corresponding frequency effect is demonstrated. With the device working in the elastic vibration mode, the cubic coefficients are eliminated by using a free end to release the nonlinear extension of beams and thus the inside axial stress. The amplitude-frequency (A-f) effect is overcome in a large region of source power, and the coefficient of frequency softening is linearized in a large region of polarization voltage. As a result, the resonator can be driven at larger vibration amplitude to achieve a high signal to noise ratio and power handling performance.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongyang Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "X. M. Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Yong Wang",
                "org": ""
            },
            {
                "name": "X. Q. Liu",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Yangyang Guan",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2018
    },
    "xRwTxRQI": {
        "id": "xRwTxRQI",
        "title": "Electrostatic charge sensor based on micro resonator with sensing scheme of effective stiffness perturbation",
        "abstract": "A resonant electrostatic charge sensor with high sensitivity based on micro electromechanical system technology is proposed to measure electric charge. During measurement, input charge produces lateral electrostatic force to change effective stiffness of double-ended tuning forks resonator, and lead to a resonant frequency shift. The charge sensing functionality is experimentally verified and the sensitivity is found to be 4.4\u00d710 \u22124  Hz/fC 2 . We show that the proposed scheme has a higher sensitivity compared to the traditional axial strain modulation counterpart. The charge sensing scheme also introduces electrical coupling inside the device to create additional energy transmission path that improve quality factor. The resonant frequency stability associated with linear transduction and instability associated with mechanical nonlinearity are investigated.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongyang Chen",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Jiuxuan Zhao",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Yinshen Wang",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "international conference on micro electro mechanical systems",
        "year": 2017
    },
    "Nth5mxbf": {
        "id": "Nth5mxbf",
        "title": "Analytical and high accurate formula for electrostatic force of comb-actuators with ground substrate",
        "abstract": "Designing a comb-actuator requires calculating electrostatic force. In this paper, the analytical and high accurate formula of electrostatic force for comb-actuators with ground substrate is derived. This analytical formula enables the fringe effect to be taken into account. According to the geometric feature, the whole structure of a comb-actuator is divided into two types of units, the capacitances of which can be calculated by Schwarz\u2013Christoffel mapping. Based on the capacitance results, the electrostatic force acting on moving fingers can be obtained by the energy method. The results of electrostatic force obtained by this analytical formula are compared with that obtained by finite element method. The compared results illustrate that the analytical formula has very high accuracy for calculating electrostatic force, which is meaningful for designing comb-actuator precisely.",
        "keywords": [
            "Finite Element Method",
            "Boundary Element Method",
            "Electrostatic Force",
            "Analytical Formula",
            "Energy Method"
        ],
        "authors": [
            {
                "name": "jiangbo he",
                "org": "southwest jiaotong university"
            },
            {
                "name": "jin xie",
                "org": "southwest jiaotong university"
            },
            {
                "name": "xiaoping he",
                "org": "academy of engineering"
            },
            {
                "name": "lianming du",
                "org": "academy of engineering"
            },
            {
                "name": "wu zhou",
                "org": "university of electronic science and technology of china"
            },
            {
                "name": "zhiyuan hu",
                "org": "academy of engineering"
            }
        ],
        "venue": "Microsystem Technologies",
        "year": 2015
    },
    "5A1Sff2G": {
        "id": "5A1Sff2G",
        "title": "A MEMS piezoelectric in-plane resonant accelerometer based on aluminum nitride with two-stage microleverage mechanism",
        "abstract": "Abstract   In this paper, we firstly present a MEMS (micro-electromechanical systems) piezoelectric in-plane resonant accelerometer with two-stage microleverage mechanism. Double ended tuning fork (DETF) resonators are actuated and sensed by piezoelectric transduction with aluminum nitride (AlN). A configuration with centrosymmetrically-distributed DETF resonators and two-stage microleverage mechanisms are proposed in the piezoelectric resonant accelerometer. The optimized configuration maximizes the length of DETF resonator in a given area and the leverage mechanism amplifies the inertia force. Both these two features enhance the sensitivity of the resonant accelerometer. The sensitivity of the device is 28.4\u00a0Hz/g and the relative sensitivity is 201\u00a0ppm/g (at the base frequency around 140.7\u00a0kHz), which are 57% and 268% higher than previously reported data. The nonlinearity characteristic and features of differential structure are also studied.",
        "keywords": "",
        "authors": [
            {
                "name": "Yixiang Wang",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310027, People\u2019s Republic of China"
            },
            {
                "name": "Hong Ding",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310027, People\u2019s Republic of China"
            },
            {
                "name": "Xianhao Le",
                "org": ""
            },
            {
                "name": "Wen Wang",
                "org": "School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou 310018, People\u2019s Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "Sensors and Actuators A-physical",
        "year": 2017
    },
    "b9lv5oTN": {
        "id": "b9lv5oTN",
        "title": "A Miniature System for Separation and Detection of PM Based on 3-D Printed Virtual Impactor and QCM Sensor",
        "abstract": "In this paper, we report a miniature system for separation and detection of particulate matter (PM) based on a 3-D printed virtual impactor (VI) and a quartz crystal microbalance (QCM) sensor. The VI is optimized by computational fluid dynamics (CFD) simulation to have a minor wall loss and relatively small size of 24 mm    $times$    24 mm    $times$    10 mm, which is utilized for classifying airborne particles according to their size, and the cutoff diameter of the VI is designed to be    $d_{0} = 2.5,,mu text{m}$   . The mass concentration of the separated particles is detected by measuring the frequency shift of the QCM sensor. In order to reliably capture particles, the QCM electrode is coated with a thin photoresist film (420 nm) to enhance surface adhesion. The performance of the miniature PM monitoring system is characterized through classification and detection of silicon dioxide particles with diameter ranging from 0.5 to 8    $mu text{m}$    in a chamber. The experimental results show that particles with diameter smaller than 2.5    $mu text{m}$    are successfully separated from the inlet flow by the VI and detected by the QCM sensor. Moreover, the sensor shows a good sensitivity of 0.0554 Hz/min per    $mu text{g}/text{m}^ {3}$   .",
        "keywords": "",
        "authors": [
            {
                "name": "Yong Wang",
                "org": ""
            },
            {
                "name": "Yinshen Wang",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Dongyang Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Xinxin Liu",
                "org": ""
            },
            {
                "name": "Changju Wu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "IEEE Sensors Journal",
        "year": 2018
    },
    "BUdiBCMJ": {
        "id": "BUdiBCMJ",
        "title": "A Mode-Selectable Beam Resonator Based on Sectionalized Electrodes",
        "abstract": "In this paper, a mode-selectable beam resonator based on sectionalized electrodes is presented. By configuring the location and number of driving and sensing electrodes, the vibration mode and the resonant frequency can be changed. Therefore, the proposed resonator can provide wide-frequency tuning. Under vacuum level of 2 Pa, the resonant frequencies of the 1 st , 2 nd  and 3 rd  modes are 67 kHz, 211 kHz and 431 kHz respectively. Nonlinear behavior of higher modes in this clamped-clamped beam resonator at different driving conditions is presented. The resonator was fabricated in an SOI (silicon on insulator) wafer and tested via open-loop spectral response measurement. The mode selectable resonator can be applied to resonant sensors with tunable sensitivity, and applications which need to work at higher frequencies.",
        "keywords": "",
        "authors": [
            {
                "name": "Yangyang Guan",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Hong Ding",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Dongyang Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Zhonggui Xu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "uGQLbuFG": {
        "id": "uGQLbuFG",
        "title": "Piezoelectric micromachined ultrasonic transducers with low thermoelastic dissipation and high quality factor",
        "abstract": "Thermoelastic dissipation is one of the main dissipative mechanisms in piezoelectric micromachined ultrasonic transducers (pMUTs). In this paper, we firstly propose pMUTs with etching holes to decrease thermoelastic dissipation and enhance quality factor (Q). The etching holes effectively disturb heat flow, and thus reduce thermoelastic loss. Working mechanism based on the Zeneru0027s model is interpreted. The experiment results show that the Q of pMUT with three rows of holes is increased by 139% from 2050 to 4909 compared with the traditional one. Temperature coefficient of frequency (TCF) and vibration performance are also improved. The enhanced pMUT can be widely used in measurement of Doppler shift and relative high power applications.",
        "keywords": "",
        "authors": [
            {
                "name": "X. M. Chen",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People\u2019s Republic of China"
            },
            {
                "name": "X. Q. Liu",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People\u2019s Republic of China"
            },
            {
                "name": "Tao Wang",
                "org": "School of Microelectronics and Solid-State Electronics, University of Electronic Science and Technology of China, Chengdu, People\u2019s Republic of China"
            },
            {
                "name": "Xianhao Le",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People\u2019s Republic of China"
            },
            {
                "name": "Fangyi Ma",
                "org": "College of Mechanical and Electrical Engineering, Shaoxing Vocational and Technological College, Shaoxing 312000, People\u2019s Republic of China"
            },
            {
                "name": "Chengkuo Lee",
                "org": "Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering Drive 3, Singapore 11757, Singapore"
            },
            {
                "name": "Jin Xie",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People\u2019s Republic of China"
            }
        ],
        "venue": "Journal of Micromechanics and Microengineering",
        "year": 2018
    },
    "5lQOIZln": {
        "id": "5lQOIZln",
        "title": "Methods for Nonlinearities Reduction in Micromechanical Beams Resonators",
        "abstract": "In this paper, two methods for reducing the nonlinearities in microelectromechanical systems flexural beams resonators have been demonstrated with established theoretical models and validated experimental results. The first method improves the conventional method of mutual cancellation between nonlinearities, in which the electrical nonlinearity has been decoupled utilizing the tuning capacitors inside a comb-drive DETF resonator to be used to controllably cancel the mechanical nonlinearity, which makes the nonlinearity reduction tunable and, meanwhile, alleviates the discontinuity of frequency spectrum, thus improving the frequency stability. The second method based on a fundamental view to redesign the DETF resonator into a doublefree semicircular beam resonator that can be operated at an elastic mode to eliminate the axial extension existing in the stretch mode of DETF and minimize the  A-f  effect. The proposed methods can effectively reduce the nonlinearity to achieve resonators with a wide linear regime, high signal-to-noise ratio, and good capability of power handling. [2017-0313]",
        "keywords": "",
        "authors": [
            {
                "name": "Dongyang Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Yong Wang",
                "org": ""
            },
            {
                "name": "Yangyang Guan",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "X. M. Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "X. Q. Liu",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Jin Xie",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, China"
            }
        ],
        "venue": "IEEE\\/ASME Journal of Microelectromechanical Systems",
        "year": 2018
    },
    "tMxf52uZ": {
        "id": "tMxf52uZ",
        "title": "A Piezoelectric Micro-Machined Ultrasonic Transducer Array Based on Flexible Substrate",
        "abstract": "Flexible electronic devices are developing rapidly, especially in the medical field. This paper reports a flexible piezoelectric micro-machined ultrasonic transducer (FPMUT) array. In the designing process, we utilize the flexible interconnection as the electrical connecting wire between piezoelectric ceramics array. Meanwhile, the polydimethylsiloxane (PDMS) films act as flexible substrates for the whole device. It has flexibility and good conformal contacting with skin surfaces. This sandwich-structure of the FPMUT has a combination of rigid and flexible features. It also has great potential for the application in ultrasound medicine in the future and could bring them closer to commercial production.",
        "keywords": "",
        "authors": [
            {
                "name": "Qifeng Zhu",
                "org": "Soochow University, Jiangsu Provincial Key Laboratory of Advanced Robotics & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, 215123, China"
            },
            {
                "name": "Lue Zhang",
                "org": "Soochow University, Jiangsu Provincial Key Laboratory of Advanced Robotics & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, 215123, China"
            },
            {
                "name": "Huicong Liu",
                "org": "Soochow University, Jiangsu Provincial Key Laboratory of Advanced Robotics & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, 215123, China"
            },
            {
                "name": "Tao Chen",
                "org": "Soochow University, Jiangsu Provincial Key Laboratory of Advanced Robotics & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, 215123, China"
            },
            {
                "name": "Lining Sun",
                "org": "Soochow University, Jiangsu Provincial Key Laboratory of Advanced Robotics & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, 215123, China"
            },
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "8PomtY3L": {
        "id": "8PomtY3L",
        "title": "Distilling determination of water content in hydraulic oil with a ZnO/glass surface acoustic wave device",
        "abstract": "Detection of water content in hydraulic oil is critical to identify abnormal wear conditions for purpose of predicting possible machinery failure in hydraulic systems. The paper reports a feasibility study of measuring the water content in the hydraulic oil using a ZnO thin film surface acoustic wave (SAW) device combined with the standard distillation method. The shift of resonant frequency of the SAW device increases with the increase of water content in hydraulic oil, and reaches 919 kHz for 0.80 wt% water content in oil samples. The results indicate that the ZnO SAW sensor can detect water content in hydraulic oil with high sensitivity.",
        "keywords": "",
        "authors": [
            {
                "name": "Zebing Mao",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Jiuxuan Zhao",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Weipeng Xuan",
                "org": "Department of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Wenbo Wang",
                "org": "Department of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, People's Republic of China 310027"
            },
            {
                "name": "Jikui Luo",
                "org": "Department of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, People's Republic of China 310027 and Institution of Renewable Energy and Environmental Technologies, U ..."
            },
            {
                "name": "Jin Xie",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, People's Republic of China 310027"
            }
        ],
        "venue": "Microsystem Technologies",
        "year": 2017
    },
    "Xi2lP9T0": {
        "id": "Xi2lP9T0",
        "title": "Study on Information Security Based on State Inspection Packet Filtering Technology",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chao gao",
                "org": ""
            },
            {
                "name": "jin xie",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2011
    },
    "cGClUR5s": {
        "id": "cGClUR5s",
        "title": "Maintenance of human haematopoietic stem and progenitor cells in vitro using a chemical cocktail.",
        "abstract": "Identification of effective culture conditions to maintain and possibly expand human HSPCs in vitro is an important goal. Recent advances highlight the efficacy of chemicals in maintaining and converting cell fates. We screened 186 chemicals and found that a combination of CHIR-99021, Forskolin and OAC1 (CFO) maintained human CD34-positive cells in vitro. Efficiency of the culture system was characterized using flow cytometry for CD34-positive cells, a colony-forming assay and xeno-transplants. We found that human CD34-positive cells treated with this combination had enhanced expression of human HSPC markers and increased haematopoietic re-populating ability in immune-deficient mice. Single-cell RNA-seq analyses showed that the in vitro cultured human CD34-positive cells were heterogeneous. We found that CFO supports maintenance of human CD34-positive cells by activating ,  and AKT-cAMP signaling pathway. These data have implications in therapies requiring maintenance and/or expansion of human HSPCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Mengmeng Jiang",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Haide Chen",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Shujing Lai",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Renying Wang",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Yunfei Qiu",
                "org": "3Institute of Hematology, First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, Hangzhou, 310003 China."
            },
            {
                "name": "Fang Ye",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Lijiang Fei",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Huiyu Sun",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Yang Xu",
                "org": "4UT-ORNL Graduate School of Genome Science and Technology, The University of Tennessee, Knoxville, TN 37996 USA."
            },
            {
                "name": "Xinyi Jiang",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Ziming Zhou",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Tingyue Zhang",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Yanwei Li",
                "org": "5Core Facilities, Zhejiang University School of Medicine, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Jin Xie",
                "org": "6Institute of Mechatronic Control Engineering, Zhejiang University, Zhejiang, Hangzhou, 310027 China."
            },
            {
                "name": "Qun Fang",
                "org": "7Department of Chemistry, Institute of Microanalytical Systems, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "Robert Peter Gale",
                "org": "8Department of Medicine, Haematology Research Centre, Division of Experimental Medicine, Imperial College London, London, UK."
            },
            {
                "name": "Xiaoping Han",
                "org": "2Stem Cell Institute, Zhejiang University, Zhejiang, Hangzhou, 310058 China."
            },
            {
                "name": "He Huang",
                "org": "Alliance for Atlas of Blood Cells, Hangzhou, China."
            },
            {
                "name": "Guoji Guo",
                "org": "Zhejiang Provincial Key Lab for Tissue Engineering and Regenerative Medicine, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang, Hangzhou, 310058 China."
            }
        ],
        "venue": "Cell discovery",
        "year": 2018
    },
    "DWpgHsD1": {
        "id": "DWpgHsD1",
        "title": "A micro resonant charge sensor with enhanced sensitivity based on differential sensing scheme and leverage mechanisms",
        "abstract": "This letter reports a micro-electro-mechanical systems (MEMS) resonant charge sensor with enhanced sensitivity based on differential sensing scheme and leverage mechanisms. The sensor comprises two symmetrically-distributed double-ended tuning fork (DETF) resonators, each of which connects with dual micro-leverage mechanisms. The micro-leverages amplify electrostatic force in opposite directions and cause differential frequency shift of the two resonators. Both the resonators show a similar trend in behaviors of electrical and mechanical nonlinearity. Effect of environment disturbance is suppressed by the differential sensing scheme. The measured sensitivity of the two resonators are 3.31\u00d710-4 Hz/fC2 and 1.85\u00d710-4 Hz/fC2 respectively, and an overall sensitivity for the resonant charge sensor is 5.16\u00d710-4 Hz/fC2.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongyang Chen",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People\u2019s Republic of China"
            },
            {
                "name": "Jiuxuan Zhao",
                "org": ""
            },
            {
                "name": "Zhonggui Xu",
                "org": "The State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People\u2019s Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "AIP Advances",
        "year": 2016
    },
    "Nm9s8jPk": {
        "id": "Nm9s8jPk",
        "title": "A humidity sensor based on AlN Lamb wave resonator coated with graphene oxide of different concentrations",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jintao Pang",
                "org": ""
            },
            {
                "name": "Xianhao Le",
                "org": ""
            },
            {
                "name": "Zhen Xu",
                "org": ""
            },
            {
                "name": "Chao Gao",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "Journal of Micromechanics and Microengineering",
        "year": 2018
    },
    "o8VYxlYI": {
        "id": "o8VYxlYI",
        "title": "A Humidity Sensor Based on Lamb Wave Resonator with Different Graphene Oxide Film",
        "abstract": "A high-performance humidity sensor coated with different graphene oxide (GO) film is presented in this paper. The porous structure and oxygen-containing groups of GO promote great humidity-sensing properties. Based on the detection of resonant frequency shift, this sensor exhibits a superior sensitivity of 26 kHz/%RH at 10%-90% relative humidity. The sensor also demonstrates a linear temperature coefficient of frequency, a little hysteresis, and short response (~9s) / recovery (~11s) time. Therefore, this humidity sensor with GO sensing film shows great potential in practical applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Jintao Pang",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Wei Huang",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "i8I0CEUQ": {
        "id": "i8I0CEUQ",
        "title": "High Quality Factor PMUTs with Optimized Thermo-Elastic Dissipation through Etching Holes",
        "abstract": "Thermoelastic dissipation (TED) is one of the main dissipative mechanisms in piezoelectric micromachined ultrasonic transducers (pMUTs). In this paper, we propose pMUTs with etching holes to decrease thermoelastic dissipation and enhance quality factor (Q). The etching holes effectively disturb heat flow, and thus reduce thermoelastic loss. Working mechanism based on the Zeneru0027s model is interpreted. The pMUT with three rows of holes has Q nearly two times higher than the traditional one. Temperature coefficient of frequency (TCF) and vibration performance are also improved. The enhanced pMUT can be widely used in measurement of Doppler shift and some relative high power applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Xuying Chen",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Xinxin Liu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Tao Wang",
                "org": "University of Electronic Science and Technology of China, School of Microelectronics and Solid-State Electronics, Chengdu, People's Republic of China"
            },
            {
                "name": "Xianhao Le",
                "org": "University of Electronic Science and Technology of China, School of Microelectronics and Solid-State Electronics, Chengdu, People's Republic of China"
            },
            {
                "name": "Zhonggui Xu",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            },
            {
                "name": "Chengkuo Lee",
                "org": "National University of Singapore, Department of Electrical and Computer Engineering, 4 Engineering Drive 3, 11757, Singapore"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, The State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, Zhejiang, People's Republic of China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "nfUW8LdT": {
        "id": "nfUW8LdT",
        "title": "Sensitivity manipulation on micro-machined resonant electrometer toward high resolution and large dynamic range",
        "abstract": "A micro-resonant electrometer with the scheme of sensitivity manipulation is proposed to realize the high resolution and large dynamic range based on a mechanical resonator and actuator. As the key sensing element, the double-ended tuning fork resonator has a quality factor close to 10\u2009000 and low motional resistance below 0.5 M\u03a9. Electrical and mechanical nonlinear features of the resonator are investigated. The charge sensing functionality based on the axial strain modulation scheme is calibrated with a high resolution of 2.6 fC under 0.46\u2009ppm frequency fluctuation. With the manipulation, the sensitivity is linearized from quadratic and further decreased to extend the dynamic range by 358.47% up to 12.38 pC. Meanwhile, the frequency fluctuation is also stabilized under 70 mHz to enhance the short-term stability of the sensor.",
        "keywords": "",
        "authors": [
            {
                "name": "Dongyang Chen",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Jiuxuan Zhao",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Yong Wang",
                "org": ""
            },
            {
                "name": "Zhonggui Xu",
                "org": "State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou 310027, People's Republic of China"
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2018
    },
    "1WBMP2PQ": {
        "id": "1WBMP2PQ",
        "title": "Environmental Sensing: Designing an Efficient Multimode Environmental Sensor Based on Graphene\u2013Silicon Heterojunction (Adv. Mater. Technol. 4/2017)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Khurram Shehzad",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Tianjin Shi",
                "org": "Key Laboratory of Micro\u2010Nano Electronics and Smart System of Zhejiang Province College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials Zhejiang University Hangzhou 310027 China"
            },
            {
                "name": "Akeel Qadir",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Xia Wan",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Hongwei Guo",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Ayaz Ali",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Weipeng Xuan",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Hua Xu",
                "org": "State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China"
            },
            {
                "name": "Zhongze Gu",
                "org": "State Key Laboratory of Bioelectronics, Southeast University, Nanjing, China"
            },
            {
                "name": "Xinsheng Peng",
                "org": "College of Material Science, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Jin Xie",
                "org": "State Key Laboratory of Fluid Power & Mechatronic systems, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Litao Sun",
                "org": "SEU-FEI Nano-Pico Center, Key Laboratory of MEMS of the Ministry of Education, Southeast University, Nanjing, China"
            },
            {
                "name": "Qiyuan He",
                "org": "Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA"
            },
            {
                "name": "Zhen Xu",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Chao Gao",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "You-Seung Rim",
                "org": "School of Intelligent Mechatronic Engineering, Sejong University, Gwangjin-gu, Seoul, Republic of Korea"
            },
            {
                "name": "Yaping Dan",
                "org": "Joint Institute of University of Michigan and Shanghai Jiaotong University Shanghai China"
            },
            {
                "name": "Tawfique Hasan",
                "org": "Cambridge Graphene Centre, University of Cambridge, Cambridge, UK"
            },
            {
                "name": "Pingheng Tan",
                "org": "State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing, China"
            },
            {
                "name": "Erping Li",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Wenyan Yin",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Zhiyuan Cheng",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Bin Yu",
                "org": "College of Nanoscale Science and Engineering, State University of New York, NY, USA"
            },
            {
                "name": "Yang Xu",
                "org": "Key Laboratory of Micro-Nano Electronics and Smart System of Zhejiang Province, College of Information Science and Electronic Engineering and State Key Laboratory of Silicon Materials, Zhejiang University, Hangzhou, China"
            },
            {
                "name": "Jikui Luo",
                "org": "Institute of Renewable Energy & Environment Technologies, University of Bolton, Bolton, UK"
            },
            {
                "name": "Xiangfeng Duan",
                "org": "Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, USA"
            }
        ],
        "venue": "Advanced materials and technologies",
        "year": 2017
    },
    "EVpzBMFO": {
        "id": "EVpzBMFO",
        "title": "Highly Sensitive AIN Surface Acoustic Wave Humidity Sensor Based on Uniform Graphene Oxide Thin Film Formed by Surface Tension",
        "abstract": "This paper proposes a high performance surface acoustic wave (SAW) humidity sensor based on uniform thin graphene oxide film. A simple and convenient film-forming process is used to prepare the GO film repeatedly and steadily, which utilizing the surface tension of GO solution. With the help of the uniform GO film, the sensor shows a high sensitivity (25.3 kHz/%RH) in a wide humidity detection range from 10%RH to 90 % RH with very little humidity hysteresis (less than 1%RH). Good reversibility, excellent short term repeatability and stability of the sensor are obtained. Moreover, the sensor also shows fast response and recovery time of 10 and 7 seconds respectively.",
        "keywords": "",
        "authors": [
            {
                "name": "Xianhao Le",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            },
            {
                "name": "Jintao Pang",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            },
            {
                "name": "Xuying Chen",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            },
            {
                "name": "Dongsheng Li",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            },
            {
                "name": "Zhen Xu",
                "org": "Department of Polymer Science and Engineering, Zhejiang University, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Hangzhou, 310027, China"
            },
            {
                "name": "Chao Gao",
                "org": "Department of Polymer Science and Engineering, Zhejiang University, MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Hangzhou, 310027, China"
            },
            {
                "name": "Jin Xie",
                "org": "Zhejiang University, State Key Laboratory of Fluid Power and Mechatronic Systems, Hangzhou, 310027, China"
            }
        ],
        "venue": "nano micro engineered and molecular systems",
        "year": 2018
    },
    "rGID4V4Z": {
        "id": "rGID4V4Z",
        "title": "A dual-driving piezoelectric DETF resonator with high quality factor and low multimode effect",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "X. Q. Liu",
                "org": ""
            },
            {
                "name": "Yixiang Wang",
                "org": ""
            },
            {
                "name": "Xianhao Le",
                "org": ""
            },
            {
                "name": "Zhonggui Xu",
                "org": ""
            },
            {
                "name": "Changju Wu",
                "org": ""
            },
            {
                "name": "Jin Xie",
                "org": ""
            }
        ],
        "venue": "Journal of Micromechanics and Microengineering",
        "year": 2018
    },
    "AQhzxJm4": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Weiwei Ma",
                "org": "Spine Surgery"
            }
        ],
        "title": "Comparison of effectiveness of Halo-femoral traction after anterior spinal release in severe idiopathic and congenital scoliosis: A retrospective study",
        "abstract": "Background. Halo-femoral traction could gradually improve the coronal and sagittal deformity and restore the trunk balance through the elongation of the spine. The purpose of this retrospective study was to assess the effectiveness of Halo-femoral traction after anterior spinal release in the management of severe idiopathic and congenital scoliosis. Methods. Sixty patients with severe and rigid curve treated with anterior spinal release, Halo-femoral traction, and second stage posterior spinal fusion were recruited for this retrospective study. Idiopathic Scoliosis (IS) group was 30 patients (23 females and 7 males) with mean age of 15.5 years. The average coronal Cobb angle was 91.6\u00b0 and the mean global thoracic kyphosis was 50.6\u00b0. The curve type of these patients were 2 with Lenke 1AN, 4 with Lenke 1A+, 1 with Lenke 1BN, 10 with Lenke 1CN, 3 with Lenke 1C+, 3 with Lenke 3CN, 3 with Lenke 3C+, and 4 with Lenke 5C+. Congenital Scoliosis (CS) group included 30 patients (20 females and 10 males) with average age of 15.2 years. The average coronal Cobb angle of the main curve before operation was 95.7\u00b0 and the average thoracic kyphosis was 70.2\u00b0. All patients had a minimum 12-month follow-up radiograph (range 12-72 months, mean 38 months). Results. The average traction time was 23 days and the average traction weight was 16 kg. Four patients experienced brachial plexus palsy and complete nerve functional restoration was achieved at two months follow-up. For the IS group, the post-operative mean Cobb angle of major curve averaged 40.1\u00b0 with correction rate of 57.5%. For the CS group, the post-operative mean Cobb angle was 56.5\u00b0 with average correction rate of 45.2%. The difference in curve magnitude between the IS and CS patients after posterior correction was statistically significant (t = 4.15, p < 0.001). The correction rate of kyphosis between IS and CS patients was also statistically significant (t = -2.59, p < 0.016). Conclusion. Halo-femoral traction was a safe, well-tolerated and effective method for the treatment of severe and rigid scoliosis patients. The posterior correction rate obtained after anterior release and traction was significant superior than that recorded from side bending film in current study.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Orthopaedic Surgery and Research",
        "year": 2007,
        "id": "AQhzxJm4"
    },
    "UZanoAbq": {
        "authors": [
            {
                "name": "Jun Jiang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Saihu Mao",
                "org": "Spine Surgery"
            },
            {
                "name": "Qinghua Zhao",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "The influence of elastic orthotic belt on sagittal profile in adolescent idiopathic thoracic scoliosis: A comparative radiographic study with Milwaukee brace",
        "abstract": "Background: The effectiveness of bracing on preventing curve progression in coronal plane for mild and moderate adolescent idiopathic scoliosis (AIS) patients has been confirmed by previous radiographic researches. However, a hypokyphotic effect on the sagittal plane has been reported by a few studies. A relatively increasing number of AIS patients were noticed to wear a new kind of elastic orthotic belt for the treatments of scoliosis without doctors' instructions. We postulate the correcting mechanism of this new appliance may cause flattening of the spine. To our knowledge, no study has investigated the effects of this new orthosis on the sagittal profile of AIS patients. The aim of this study was to evaluate and compare the effects of elastic orthotic belt and Milwaukee brace on the sagittal alignment in AIS patients. Methods: Twenty-eight female AIS patients with mild or moderate thoracic curves were included in this study. Standing full-length lateral radiographs were obtained in three conditions: natural standing posture without any treatment, with elastic orthotic belt and with Milwaukee brace. Thoracic kyphosis (TK), lumber lordosis (LL) and pelvic incidence (PI) were measured and compared between the above three conditions. Results: Both elastic orthotic belt and Milwaukee brace can lead to significant decrease of TK, however, the decrease of TK after wearing elastic orthotic belt is significantly larger than that after wearing Milwaukee brace. Compared with no treatment, LL was found to be significantly smaller after wearing Milwaukee brace, however, such significant decrease was not noted after wearing elastic orthotic belt. No significant changes were observed for the PI between 3 conditions. Conclusions: The elastic orthotic belt could lead to more severe thoracic hypokyphosis when compared with Milwaukee brace. This belt may not be a suitable conservative method for the treatment of mild and moderate AIS patients. \u00a9 2010 Jiang et al; licensee BioMed Central Ltd.",
        "keywords": [
            ""
        ],
        "venue": "BMC Musculoskeletal Disorders",
        "year": 2010,
        "id": "UZanoAbq"
    },
    "YLvqMwya": {
        "authors": [
            {
                "name": "Yanxiang Sun",
                "org": "Department of Cardiovascular Medicine"
            },
            {
                "name": "Yuhua Liao",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yong Yuan",
                "org": "Department of Cardiovascular Medicine"
            },
            {
                "name": "Li Feng",
                "org": "Department of Cardiovascular Medicine"
            },
            {
                "name": "Shihui Ma",
                "org": "Department of Cardiovascular Medicine"
            },
            {
                "name": "Feng Wei",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Min Wang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Feng Zhu",
                "org": "Laboratory of Cardiovascular Immunology"
            }
        ],
        "title": "Influence of autoantibodies against AT1 receptor and AGTR1 polymorphisms on candesartan-based antihypertensive regimen: Results from the Study of Optimal Treatment in Hypertensive Patients with Anti-AT 1-Receptor Autoantibodies trial",
        "abstract": "The autoantibodies against angiotensin AT",
        "keywords": [
            "angiotensin-receptor blockers",
            "autoantibodies",
            "Hypertension",
            "polymorphism"
        ],
        "venue": "Journal of the American Society of Hypertension",
        "year": 2014,
        "id": "YLvqMwya"
    },
    "2jjPN7AD": {
        "authors": [
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Jun Jiang",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            }
        ],
        "title": "How is the trachea at risk of injury from pedicle screw insertion in proximal thoracic curve of adolescent idiopathic scoliosis patients?",
        "abstract": "Purpose: The rotation or translation of vertebrae in adolescent idiopathic scoliosis (AIS) patients could cause the relative migrations of surrounding vital structures and lead to smaller safe zones for pedicle screw insertion. This study aimed to determine the changed relative position of trachea to spine in the proximal thoracic curve (T1-T4) and to analyze the potential risks of tracheal injuries from pedicle screw insertions in AIS patients. Methods: Twenty-three patients with complete proximal thoracic curve (CPT group), 25 patients with fractional proximal thoracic curve (FPT group) and 19 normal subjects with a straight spine (normal group) were included. Axial computed tomography images from T1 to T4 level were obtained to evaluate trachea-vertebral distance (TVD, the closest distance between trachea and vertebral body) and trachea-vertebral angle (TVA, defined as 0 when the trachea was located directly laterally to the left and 180 when directly laterally to the right). The extension line of pedicle axis could cross the anterior wall of vertebra and the posterior wall of the trachea at two points when the trachea was located in the trajectory of the screw passage. If the distance between the two points was less than 5 mm, the trachea was considered to be at a potential risk of injury. The percentages of vulnerable trachea were calculated at each level. Results: The TVA in the CPT group was significantly larger than that in the FPT group and in the normal group, while the TVA in the FPT group was significantly larger than that in the normal group at the T2-T4 level. The TVD in the FPT group was significantly smaller than that in the CPT group and in the normal group at each level, while the TVD in the CPT group was significantly smaller than that in the normal group at the T2 and T3 levels. No trachea was found to be at risk from screw insertion on both sides in both the CPT group and the normal group. However, it was at a high risk of injury from anterior cortex penetration during right screw insertion in the FPT group. The percentage of trachea at risk from right screw insertion was 40 % at T1 level, 92 % at T2 level, 100 % at both T3 and T4 levels. Conclusions: This CT-based study demonstrates that the FPT curve has a smaller safe zone with respect to tracheal injury during screw insertion. Spine surgeons should choose the appropriate screw length to avoid anterior wall perforation. \u00a9 2012 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "Computed tomography",
            "Pedicle screw",
            "Scoliosis",
            "Trachea"
        ],
        "venue": "European Spine Journal",
        "year": 2013,
        "id": "2jjPN7AD"
    },
    "Pje0zauC": {
        "authors": [
            {
                "name": "Shoufeng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Weiwei Ma",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            }
        ],
        "title": "Comparison of disc and vertebral wedging between patients with adolescent idiopathic scoliosis and chiari malformation-associated scoliosis",
        "abstract": "STUDY DESIGN: A comparative study. OBJECTIVE: To investigate the difference of disc and vertebral wedging between patients with adolescent idiopathic scoliosis (AIS) and Chiari malformation-associated scoliosis (CMS). SUMMARY OF BACKGROUND DATA: The wedging of disc and vertebral wedging of AIS are well investigated. However, the comparison of that wedging between AIS and CMS is not found in the literature. METHOD: This study included 35 cases of AIS and 31 cases of CMS. The disc and vertebral wedging was measured by Cobb method. The percentage of single disc and vertebral wedging in the whole thoracic or lumbar curve was calculated. The difference between disc and vertebral wedging, the apical vertebra and average adjacent vertebrae wedging, the apical discs and adjacent discs wedging in the same curve location, same diagnosis and similar Cobb angle group was compared. The difference of disc or vertebral wedging between AIS and CMS, Cobb angle <60 degrees and 60 degrees was also compared. The correlation between the apical vertebral wedging angle and Cobb angle was performed by Pearson correlation analysis. RESULTS: The difference between disc and vertebral wedging in the same curve location, same diagnosis, and similar Cobb angle group was statistically significant (P<0.05). No significant difference of the disc or vertebral wedging was found between AIS and CMS in the same curve location and the similar Cobb angle group (P>0.05). No significant difference of the disc or vertebral wedging was found between Cobb angle <60 degrees and 60 degrees groups in the same curve location and the same diagnosis (P>0.05). There was a positive correlation between the apical vertebra wedging angle and Cobb angle in AIS patients and CMS patients. The wedging of apical vertebra and disc was more than that in the adjacent disc and vertebra in the same curve. CONCLUSIONS: The relative wedging of intervertebral disc and vertebrae with AIS patients is similar to that of scoliosis with known cause (CMS). The wedging of discs and vertebrae in AIS patients may be an adaptive change secondary to some extravertebral factors. Copyright \u00a9 2012 by Lippincott Williams & Wilkins.",
        "keywords": [
            "diagnosis",
            "disc",
            "scoliosis",
            "vertebrae",
            "wedging"
        ],
        "venue": "Journal of Spinal Disorders and Techniques",
        "year": 2012,
        "id": "Pje0zauC"
    },
    "m0l1k9De": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Medical School"
            },
            {
                "name": "Zhen Liu",
                "org": "Medical School"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Medical School"
            },
            {
                "name": "Bangping Qian",
                "org": "Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Medical School"
            },
            {
                "name": "Tao Wu",
                "org": "Medical School"
            },
            {
                "name": "Jun Jiang",
                "org": "Medical School"
            },
            {
                "name": "Xu Sun",
                "org": "Medical School"
            },
            {
                "name": "Xusheng Qiu",
                "org": "Medical School"
            },
            {
                "name": "Weiwei Ma",
                "org": "Medical School"
            },
            {
                "name": "Weijun Wang",
                "org": "Medical School"
            }
        ],
        "title": "Comparison of sagittal spinopelvic alignment in chinese adolescents with and without idiopathic thoracic scoliosis",
        "abstract": "Study Design. A retrospective radiographical study investigated the sagittal alignment in healthy Chinese girls and Chinese girls with idiopathic thoracic scoliosis (T-AIS). Objective. To evaluate the sagittal alignment of the pelvis and spine in Chinese girls with idiopathic scoliosis and healthy girls and to assess whether the pelvic morphology differed between white and Chinese girls with AIS. Summary of Background Data. It has been shown that patients with AIS have an abnormal spinopelvic balance and pelvic morphology. Race is a determinant factor of sagittal spinal alignment and serves as a reminder when planning surgical reconstruction for spinal deformity. Until now, there have been no studies documenting the sagittal lumbosacral spine morphology in Chinese girls with T-AIS. Methods. In this study, 95 patients with T-AIS and 33 healthy age-matched adolescents were recruited consecutively. Sagittal spinal and pelvic parameters were measured from the standing lateral radiograph, including thoracic kyphosis (TK), lumbar lordosis (LL), upper arc of LL, lower arc of LL, pelvic incidence (PI), sacrum slope (SS), and pelvic tilt (PT). Analysis of variance was used in the comparison of each dependent variable between patients with AIS and healthy adolescents. The relations between all parameters were determined via Pearson correlation coefficient (r). Results. For all the sagittal parameters, only the TK and the upper arc of the LL showed significant differences between girls with AIS and healthy girls. The LL, lower arc of the LL, and 3 pelvic parameters were similar for both groups. The TK was found to be strongly correlated with LL and the upper arc of the LL in both groups. However, the TK was not related to the lower arc of the LL, nor were the 3 pelvic parameters in either group. In addition, LL was found to be associated with PI and SS in both groups. The lower arc of the LL was also correlated with PI for both groups. The PI was related to PT and SS in both groups; however, no correlation was found between PT and SS. In this study, the TK (15.7\u00b0), SS (35.1\u00b0), and PI (44.2\u00b0) were found to be significantly lower in Chinese patients with T-AIS than the values reported in the AIS cohort. Conclusion. In our study, the Chinese girls with T-AIS had similar PI, PT, and SS values when compared with the age-matched healthy girls. There were significant differences in pelvic morphology between Chinese and white girls with AIS. These results suggest that race may influence an individual's spinopelvic morphology. Although we have shown that the TK could affect LL through the upper arc of the LL directly, the evaluation of the thoracolumbar morphology of T-AIS before surgery is important for surgical planning. \u00a9 2012 Lippincott Williams & Wilkins.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "kyphosis",
            "lordosis",
            "pelvic parameter",
            "sagittal morphology"
        ],
        "venue": "Spine",
        "year": 2012,
        "id": "m0l1k9De"
    },
    "vpgzY86a": {
        "authors": [
            {
                "name": "Fei Xu",
                "org": ""
            },
            {
                "name": "Da-Wei Zhang",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "He Tang",
                "org": ""
            },
            {
                "name": "Xin Lv",
                "org": ""
            },
            {
                "name": "Jian Cheng",
                "org": ""
            },
            {
                "name": "Huang-Fan Xie",
                "org": ""
            },
            {
                "name": "Hong-Hui Lin",
                "org": ""
            }
        ],
        "title": "A novel role for cyanide in the control of cucumber (Cucumis sativus L.) seedlings response to environmental stress",
        "abstract": "The effects of potassium cyanide (KCN) pretreatment on the response of cucumber (Cucumis sativus L.) plants to salt, polyethylene glycol (PEG) and cold stress were investigated in the present study. Here, we found that KCN pretreatment improved cucumber seedlings tolerance to stress conditions with maximum efficiency at a concentration of 20\u03bcM. The results showed that pretreatment with 20\u03bcM KCN alleviated stress-induced oxidative damage in plant cells and clearly induced the activity of alternative oxidase (AOX) and the ethylene production. Furthermore, the structures of thylakoids and mitochondria in the KCN-pretreated seedlings were less damaged by the stress conditions, which maintained higher total chlorophyll content, photosynthetic rate and photosystem II (PSII) proteins levels than the control. Importantly, the addition of the AOX inhibitor salicylhydroxamic acid (1mm; SHAM) decreased plant resistance to environmental stress and even compromised the cyanide (CN)-enhanced stress tolerance. Therefore, our findings provide a novel role of CN in plant against environmental stress and indicate that the CN-enhanced AOX might contribute to the reactive oxygen species (ROS) scavenging and the protection of photosystem by maintaining energy charge homoeostasis from chloroplast to mitochondria. \u00a9 2012 Blackwell Publishing Ltd.",
        "keywords": [
            "Alternative oxidase",
            "Cucumber",
            "Environmental stress",
            "Ethylene",
            "Hydrogen peroxide",
            "Potassium cyanide",
            "Reactive oxygen species"
        ],
        "venue": "Plant, Cell and Environment",
        "year": 2012,
        "id": "vpgzY86a"
    },
    "CY2AD0s6": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Antai College of Economic and Management"
            }
        ],
        "title": "Market simulation of hedging trade mode in electricity market for reducing market operation risk",
        "abstract": "Based on the hedging theory, application of hedging theory is analyzed in the electricity market. According to contracts for differences, this paper gives a method to calculate the income of electricity traders in different circumstances. By means of a typical 39 node power system and MATPOWER simulation software, considering market power and collusion action, electricity market operation cases are discussed in a transaction day. Simulation experimental results show that CFDs can significantly reduce market risk, CFDs plus whole electricity energy bidding mode is proper during our electricity market construction.",
        "keywords": [
            "Electricity market",
            "Hedging",
            "Market simulation",
            "Risk"
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2007,
        "id": "CY2AD0s6"
    },
    "ZWUOGnSx": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            },
            {
                "name": "Xusheng Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Weiguo Li",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            }
        ],
        "title": "Decreased circulating leptin level and its association with body and bone mass in girls with adolescent idiopathic scoliosis",
        "abstract": "STUDY DESIGN. A prospective study was designed to investigate the circulating leptin level in girls with adolescent idiopathic scoliosis (AIS). OBJECTIVE. To determine the circulating leptin levels in AIS girls, and to investigate its associations with body mass and bone mass. SUMMARY OF BACKGROUND DATA. Abnormal growth pattern and osteopenia have been well documented in AIS patients throughout the peripubertal growth period. Leptin has been shown to regulate the growth of the whole body and bone particularly during childhood and adolescence. However, the circulating level of leptin, the relationships between leptin and lower body mass, and the relationships between leptin and lower bone mass in AIS patients remain unclear. METHODS. One hundred twenty AIS girls and 80 healthy controls were recruited in this study. Measurements of anthropometry and circulating leptin were performed both in AIS and non-AIS girls. Evaluations of curve severity and measurements of bone mineral content/density (BMC/BMD) were performed only in AIS girls. The anthropometric data and circulating leptin levels were compared between older AIS girls and controls. The relationships between leptin and age, menstrual status, body weight, height, body mass index (BMI), Risser sign, curve magnitude, and BMC/BMD were analyzed in AIS girls. RESULTS. Compared with healthy controls, an abnormal growth pattern (higher corrected height, lower weight, and lower BMI), and a marked decrease of circulating leptin were found in AIS girls, even after the adjustment for age and menstrual status. Positive correlations were found between leptin and age, menstrual status, body weight, height, BMI, and Risser sign. No significant correlation was found between leptin and curve magnitude. There was no significant difference in age at menarche between menstruating AIS and non-AIS girls, though an inverse correlation was observed between leptin and the age at menarche. The relationship between leptin and BMC/BMD remained significantly positive after controlling for age and menstrual status, although it was not independent of body weight or BMI. CONCLUSION. A marked decrease of circulating leptin was observed in the current study. There was an association between leptin and body weight, BMI, other growth parameters, and BMC/BMD. This correlation suggests that leptin might play an important role in the lower body and bone mass in AIS girls. \u00a9 2007 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Body mass",
            "Bone mass",
            "Girl",
            "Growth",
            "Idiopathic scoliosis",
            "Leptin"
        ],
        "venue": "Spine",
        "year": 2007,
        "id": "ZWUOGnSx"
    },
    "s18jVtqv": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Wen-Jun Chen",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Wei-Jun Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bing Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bin Zhu",
                "org": "Department of Radiology"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Migration of thoracic aorta after the anterior correction of thoracic idiopathic scoliosis without parietal pleura closure",
        "abstract": "Study Design: To compare the preoperative and postoperative relative position of the thoracic aorta to the vertebrae in patients with idiopathic scoliosis (IS) after anterior corrective surgery without parietal pleura closure. Objective: To investigate the impact of unrepaired parietal pleura on thoracic aorta migration after anterior correction of right thoracic IS. Summary of Background Data: Vascular injuries caused by vertebral screws have been reported in several studies. Recent studies showed an anteromedial shift of thoracic aorta after anterior curve correction with closure of the parietal pleura in thoracic IS. Migration of the aorta in patients with nonclosed parietal pleura has not been studied before, although it has been speculated in benefiting the transposition of the aorta and thus reduces the risk of vascular injury. Methods: Fifteen IS patients with predominant right thoracic scoliosis who underwent anterior instrumentation without parietal pleura closure were recruited for the study. There were 10 female and 5 male patients with an average age of 15.9 years. The following parameters were measured on preoperative and postoperative computed tomographic scans: angle \u03b1: aorta-vertebral angle; distance a: distance between the aorta and the left rib head; distance b: distance from aorta to vertebral body cortex. Results: From computed tomographic measurements, the angle \u03b1 from T5 to T12 ranged from 28.9 to 68.3 degrees before surgery and 18.8 to 63.2 degrees after surgery. The distance a ranged from 5.6 mm to 28.1 mm before surgery and 2.3 mm to 24.3 mm after surgery. The distance b ranged from 1.7 mm to 4.3 mm before surgery and 2.3 mm to 8.0 mm after surgery. These changes in all the parameters reached statistically significant difference at all the levels except in upper and lower end vertebrae (P<0.05). Conclusions: The thoracic aorta in patients with predominant right thoracic IS migrated posterolaterally relative to the vertebral body after anterior surgery without parietal pleura closure. Copyright \u00a9 2011 by Lippincott Williams & Wilkins.",
        "keywords": [
            "anterior spinal approach",
            "complications",
            "idiopathic scoliosis",
            "vascular"
        ],
        "venue": "Journal of Spinal Disorders and Techniques",
        "year": 2011,
        "id": "s18jVtqv"
    },
    "uvqiqbpI": {
        "authors": [
            {
                "name": "Weijun Wang",
                "org": "Department of Joint Surgery"
            },
            {
                "name": "Mingda Wu",
                "org": "Department of Joint Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Wenjie Weng",
                "org": "Department of Joint Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Sacrum pubic incidence and sacrum pubic posterior angle: two morphologic radiological parameters in assessing pelvic sagittal alignment in human adults",
        "abstract": "Purpose The morphology and position of pelvis are critical in regulating the biomechanical organization of spine-pelvis-leg in the sagittal plane. Several radiological parameters have been developed to present the sagittal morphology of the pelvis such as pelvic incidence (PI) and Jackson's angle (PRS1). In addition, the femoral sacral posterior angle (FSPA) was developed for patients with a dome-shaped deformity in the upper plate of the sacrum. The identification of hip axis, which was represented by the line connecting the centers of femoral heads in normal subjects, was important for these parameters measurement. However, in subjects with fused hip joint or deformed femoral heads, the accurate localization of hip axis become imprecise. Herein, the upper edge of the pubic symphysis, which is easy to identify on the lateral X-ray film, was selected as an alternative landmark of the hip axis, and two morphologic parameters, the sacrum pubic incidence (SPI) and sacrum pubic posterior angle (SPPA), were proposed accordingly. The present study aimed to understand the reliability of these two parameters and their value in predicting PI, PRS1 and FSPA. Methods Upright standing spine and pelvis radiographs of 60 normal adults (30 male and 30 female) with an average age of 38.5 years were obtained. Two independent observers then measured the following radiological parameters on the films: PI, PRS1, FSPA, SPI, SPPA, sacral slope, pelvic tilt and lumbar lordosis. The SPI is the angle between the line perpendicular to the superior plate of the first sacral vertebra at its midpoint and the line connecting this point to the upper edge of the pubic symphysis, while the SPPA is the angle between the line extending from the posterior upper edge of the sacrum to the upper edge of the pubic symphysis and the posterior side of the first sacral vertebral body. The intra-observer and inter-observer reliabilities of the parameters were analyzed using intraclass correlations. The correlations between parameters were analyzed by Pearson's correlation coefficients. Regression analysis was carried out to establish formulas to predict the values of PI, PRS1 and FSPA using the SPI and SPPA. A p < 0.05 was considered statistically significant. Results The SPI was 64.4\u00b0 \u00b1 9.5\u00b0 and 68.3\u00b0 \u00b1 9.4\u00b0, and the SPPA was 77.7\u00b0 \u00b1 7.5\u00b0 and 78.7\u00b0 \u00b1 9.4\u00b0 in males and females, respectively. These radiological parameters showed excellent intra- and inter-observer reliabilities, with an intraclass correlation >0.8. No gender differences were identified in these morphologic and positional radiological parameters. The SPI demonstrated strong correlation with PI and PRS1 (R",
        "keywords": [
            "Pelvic incidence",
            "Reliability",
            "Sacral pubic incidence",
            "Sacrum pubic posterior angle",
            "Sagittal alignment"
        ],
        "venue": "European Spine Journal",
        "year": 2014,
        "id": "uvqiqbpI"
    },
    "k2WK1qlK": {
        "authors": [
            {
                "name": "Jun Qiao",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Leilei Xu",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Yang Yu",
                "org": ""
            },
            {
                "name": "Bang-Ping Qian",
                "org": ""
            },
            {
                "name": "Yitao Ding",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Validation of the simplified chinese version of the core outcome measures index (COMI)",
        "abstract": "Purpose: To translate the Core Outcome Measures Index (COMI) into Simplified Chinese and then validate it for Mainland Chinese patients with low back pain (LBP). Methods: A total of 120 consecutive patients with LBP >3 months who visited our outpatient clinic from December 2011 to March 2012 were asked to complete a questionnaire booklet including the following: (1) the Roland Morris disability questionnaire (RMQ) (Fan, et al.. in Spine 37(10):875-880, 2012), (2) the Short Form Health Survey (SF-36) (Zhang, et al.. in Int J Med Sci 9(7):521-526, 2012), (3) the Oswestry Disability Index (ODI) (Liu, et al.. in Spine 34(11):1211-1216, 2009), (4) visual analogue scale (VAS) measure of pain, and (5) COMI. These patients were also asked to complete a second COMI questionnaire and a transition questionnaire (5-point Likert scale: better, a little better, no change, a little worse, worse) and to return the second COMI questionnaire via mail within 1 month. Results: The floor effects for the COMI items ranged from 5.8 to 12.5 %. High values (28.3, 27.5, and 25.8 %, respectively) were found for symptom-specific quality of life, social disability, and work disability. Regarding the ceiling effects, the social and work disabilities were relatively high at 17.5 and 24.2 %, respectively. For other items, the values ranged from 0 to 14.2 %. Neither floor nor ceiling effects were found for the COMI summary score. Excellent correlations were found between the COMI pain scores and VAS scores (Rho = 0.89) and between the COMI pain and the SF-36 bodily pain domain (Rho = 0.84). Other individual items and summary scores showed a very good correlation (Rho = 0.54-0.72) with the corresponding questionnaires except for \"symptom-specific well-being\" (0.31-0.45). One-way repeated measures ANOVA was used to determine the intraclass correlation coefficient (ICC). The ICC for the entire COMI score was 0.91 (95 % CI 0.85-0.94) and 0.81-0.86 for the two pain scores (back and leg). The \"minimum detectable change'' (MDC 95 %) for the COMI summary score was 1.91 points. No significant difference in the mean values was found for the repeated scores of individual items or the summary score. Conclusion: The Simplified Chinese version of COMI showed satisfactory reliability and good psychometric properties. This concise questionnaire is suitable for widespread use in Mainland China. \u00a9 2013 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "Cross-cultural adaptation",
            "Low back pain",
            "Outcome measure",
            "Questionnaire",
            "Simplified Chinese"
        ],
        "venue": "European Spine Journal",
        "year": 2013,
        "id": "k2WK1qlK"
    },
    "8CxOg8sM": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yanxiang Sun",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yuhua Liao",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yumiao Wei",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Ming Chen",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Min Wang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Zihua Zhou",
                "org": "Laboratory of Cardiovascular Immunology"
            }
        ],
        "title": "Agonistic at 1 receptor autoantibody increases in serum of patients with refractory hypertension and improves Ca2+ mobilization in cultured rat vascular smooth muscle cells",
        "abstract": "Agonistic AT 1 receptor autoantibodies (AT",
        "keywords": [
            "angiotensin II receptor type 1",
            "antibody",
            "Autoimmunity",
            "hypertension"
        ],
        "venue": "Cellular and Molecular Immunology",
        "year": 2008,
        "id": "8CxOg8sM"
    },
    "qpBEzRUT": {
        "authors": [
            {
                "name": "Cheng-Jian Shi",
                "org": "Department of Biliary-pancreatic Surgery"
            },
            {
                "name": "Jun Gao",
                "org": "Department of General Surgery"
            },
            {
                "name": "Min Wang",
                "org": "Department of Biliary-pancreatic Surgery"
            },
            {
                "name": "Xin Wang",
                "org": "Department of Biliary-pancreatic Surgery"
            },
            {
                "name": "Rui Tian",
                "org": "Department of Biliary-pancreatic Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Biliary-pancreatic Surgery"
            },
            {
                "name": "Ming Shen",
                "org": "Department of Biliary-pancreatic Surgery"
            },
            {
                "name": "Ren-Yi Qin",
                "org": "Department of Biliary-pancreatic Surgery"
            }
        ],
        "title": "Cd133+ gallbladder carcinoma cells exhibit self-renewal ability and tumorigenicity",
        "abstract": "AIM: To identify cancer stem cells (CSCs) in human gallbladder carcinomas (GBCs). METHODS: Primary GBC cells were cultured under serum-free conditions to produce floating spheres. The stem-cell properties of the sphere-forming cells, including self-renewal, differentiation potential, chemoresistance and tumorigenicity, were determined in vitro or in vivo. Cell surface expression of CD133 was investigated in primary tumors and in spheroid cells using flow cytometry. The sphere-colony-formation ability and tumorigenicity of CD133",
        "keywords": [
            "Cancer stem cell",
            "CD133 protein",
            "Gallbladder carcinoma",
            "Non-adherent spheres",
            "Self-renewal",
            "Tumorigenicity"
        ],
        "venue": "World Journal of Gastroenterology",
        "year": 2011,
        "id": "qpBEzRUT"
    },
    "KQJavkHF": {
        "authors": [
            {
                "name": "Rongrong Nie",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Anchun Mo",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Hongkun Wu",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Zhiqing Chen",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Yubao Li",
                "org": "The Research Center for Nano-biomaterials"
            },
            {
                "name": "Feng Zhu",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Xiaoyu Li",
                "org": "Key Lab. of Oral Biomedical Engineering"
            },
            {
                "name": "Gang He",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Xia Deng",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Yong Zhao",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Zhihong Liang",
                "org": "West China College of Stomatology"
            }
        ],
        "title": "Effects of apatite nanocrystals on proliferation, subcellular structure, protein synthesis activity of human periodontal ligament cells",
        "abstract": "To determine the cellular events occurring in the presence of yttrium/hydroxyapatite (Y/HA) or HA nanocrystals, human periodontal ligament (HPDL) cells were isolated and maintained in culture. The specificity of the cells was evidenced by their proliferation, subcellular structure, and deposition of extracellular matrix components. The presence of nanocrystals was significantly related to an increase in the proliferation. Moreover, the presence of Y/HA nanocrystals was significantly related to an increase in the proliferation with HA nanocrystals. Transmission electron microscopy (TEM) demonstrated the phagocytotic process of HPDL cells toward Y/HA or HA nanocrystals. The presence of Y/HA or HA nanocrystals was significantly related to an increase in the protein synthesis activity of HPDL cells.",
        "keywords": [
            "Hydroxyapatite",
            "Nanocrystals",
            "Periodontal ligament cells",
            "Yttrium"
        ],
        "venue": "Journal Wuhan University of Technology, Materials Science Edition",
        "year": 2005,
        "id": "KQJavkHF"
    },
    "R5Ye8Ypz": {
        "authors": [
            {
                "name": "Yun-Fei Duan",
                "org": ""
            },
            {
                "name": "Xiao-Dong Li",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Feng Zhang",
                "org": ""
            }
        ],
        "title": "Expression and clinical significance of angiotensin II type 1 receptor in human hepatocellular carcinoma",
        "abstract": "This study aimed to investigate the expression of angiotensin II type 1 receptor (AT-1R) mRNA and the AT-1R protein in human primary hepatocellular carcinoma (PHC), and to attempt to elucidate their association with pathological and clinical characteristics. Fresh tumor and normal liver tissues were obtained from 44 patients with PHC following hepatectomies. AT-1R mRNA levels were quantitatively analyzed by quantitative polymerase chain reaction (qPCR) while the protein levels were assessed by immunohistochemistry. The expression levels of AT-1R were observed in hepatocellular carcinoma tissues and normal liver tissues. The level of AT-1R protein expression in normal liver tissues was higher compared with that in PHC tissues (P=0.0033). The AT-1R mRNA levels were higher in patients with negative hepatitis B virus surface antigen (HBsAg), normal \u03b1-fetoprotein (AFP) levels and high tumor differentiation, compared with those in patients with positive HBsAg (P=0.0005), upregulated AFP levels (P=0.0008) and poor tumor differentiation (P=0.0290). No significant correlation was identified between the expression levels of AT-1R mRNA and general characteristics such as gender, age, cirrhotic nodules, tumor size, tumor encapsulation, tumor number, carcinoma embolus, tumor metastasis or tumor recurrence. Downregulated levels of AT-1R mRNA and AT-1R protein may indicate a poor prognosis for patients with PHC.",
        "keywords": [
            "Angiotensin ii type 1 receptor",
            "Differentiation",
            "Hepatocellular carcinoma"
        ],
        "venue": "Experimental and Therapeutic Medicine",
        "year": 2014,
        "id": "R5Ye8Ypz"
    },
    "l60QACRU": {
        "authors": [
            {
                "name": "Fen Liu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Zhenguo Zeng",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Rong Jiang",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Feng Zhu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Cheng Nie",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Kejian Qian",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Nonghua Lv",
                "org": "Intensive Care Unit"
            }
        ],
        "title": "Effects and the mechanism of high volume hemofiltration on acute lung injury induced by endotoxin in dogs",
        "abstract": "Objective: To study the treatment effect and the mechanism of high volume hemofiltration (HVHF) on acute lung injury (ALI) induced by endotoxin in dogs. Methods: Sixteen healthy hybrid male dogs were injected LPS (650 \u03bcg/kg) via central vein within 30 minutes. After model establishment, all animals were divided into two groups randomly ( n = 8). One group received the treatment of HVHF, while another group received routine treatment. PH, PaO",
        "keywords": [
            "Acute lung injury",
            "Endotoxin",
            "High volume hemofiltration",
            "Mechanism"
        ],
        "venue": "Chinese Journal of Emergency Medicine",
        "year": 2006,
        "id": "l60QACRU"
    },
    "CLlDPJ4a": {
        "authors": [
            {
                "name": "Xin Wang",
                "org": "Department of General Surgical"
            },
            {
                "name": "Qiu Li",
                "org": "Central Hospital of Huangshi"
            },
            {
                "name": "Shengquan Zou",
                "org": "Department of General Surgical"
            },
            {
                "name": "Ziyong Sun",
                "org": "Department of General Surgical"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of General Surgical"
            }
        ],
        "title": "Analysis of etiology and drug resistance of biliary infections",
        "abstract": "The bile was collected from fro patients with biliary infections, with the bacterium isolated to study the sensitivity of each kind of the bacterium to several antibiotics in common use. Except G- bacterium, we also found some kinds of G + bacterium in infection bile. G- bacterium were not sensitive to Clindamycin, G+ bacterium were sensitive to Ciprofloxacin. Escherichia coli, Xanthomonas maltophilia, Enterobacter cloacae, Pseudomonas aeruginosa were sensitive to Ampicillin. G+ bacterium were not sensitive to Azactam. Enterococcus faecalis, Enterococcus faecium, Enterobacter cloacae were not sensitive to Ceftazidime. Enterococcus faecalis, Staphylococcus coagulase negative, Staphylococcus epidermidis, Pseudomonas aeruginosa were not sensitive to Ceftriax-one Sodium. We didn't found any bacterium resistance Imipenem. The possibility of the existence of G+ bacterium as well as drug resistance should be considered n patients with biliary infections. The value of susceptibility test should be respected to avoid drug abuse of antibiotics.",
        "keywords": [
            "Biliary tract infection",
            "Drug resistance",
            "Susceptibility test"
        ],
        "venue": "Journal of Huazhong University of Science and Technology - Medical Science",
        "year": 2004,
        "id": "CLlDPJ4a"
    },
    "Uxe9rr1g": {
        "authors": [
            {
                "name": "Xiao Bo Cai",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Jian Jun Wen",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Lei Li",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Ru Ling Zhang",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Hui Zhou",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Xin Jian Wan",
                "org": "Department of Gastroenterology and Hepatology"
            }
        ],
        "title": "Endoscopic treatment for biliary stricture after orthotopic liver transplantation: Success, recurrence and their influencing factors",
        "abstract": "Objective: To investigate the success and recurrence rates and factors influencing the effect of endoscopic therapy for patients with biliary stricture after orthotopic liver transplantation (OLT). Methods: Data of 56 patients who underwent endoscopic therapy for biliary stricture after OLT from 2006 to 2009 were reviewed in this study. Their clinical data, laboratory parameters and endoscopic features were recorded. Results: Biliary stricture was treated successfully in 47 patients (83.9%). Compared with those with treatment failure, there was a longer duration from OLT to initial presentations (P=0.02) in the successful group, fewer endoscopic retrograde cholangiopancreatography (ERCP) treatments (P<0.01) and fewer stents inserted per patient (P<0.01). Multivariate analysis showed that the number of ERCP treatments per patient was negatively related with treatment success. Of the 47 patients successfully treated, stricture recurred in 13 (27.7%) during follow-up. Compared with those without recurrence, the recurrence group had a shorter initial presentation time after OLT, higher serum alanine aminotransferase, aspartate aminotransferase and \u03b3-glutamyltransferase levels, higher numbers of ERCP treatments and stents used and a longer duration of treatment (P<0.01 for all). Multivariate analysis showed that the treatment duration was a risk factor for recurrence (OR 2.33, 95% CI 1.34-4.05, P<0.01). Conclusions: Endoscopic treatment is a safe and effective modality for biliary stricture after OLT. The number of ERCP treatments per patient is negatively related with treatment success and long treatment duration was a risk factor for stricture recurrence. \u00a9 2012 The Authors. Journal of Digestive Diseases \u00a9 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.",
        "keywords": [
            "Biliary stricture",
            "Endoscopy",
            "Liver transplantation",
            "Recurrence",
            "Treatment"
        ],
        "venue": "Journal of Digestive Diseases",
        "year": 2012,
        "id": "Uxe9rr1g"
    },
    "KVl4iPgj": {
        "authors": [
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Burns"
            },
            {
                "name": "Shao-Gen Wang",
                "org": ""
            },
            {
                "name": "Zhong-Hua Fu",
                "org": ""
            },
            {
                "name": "Ming Yang",
                "org": ""
            },
            {
                "name": "Xing-Heng Wu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            }
        ],
        "title": "Comparing the effect of high frequency oscillatory ventilation and conventional mandatory ventilation on the myocardial function of rabbit with inhalation injury",
        "abstract": "Objective: To compare the effect of high frequency oscillatory ventilation (HFOV) and conventional mandatory ventilation (CMV) on the myocardial function of rabbits with inhalation injury. Methods: Steam inhalation injury model was reproduced in 16 New Zealand albino rabbits. They were randomly divided into CMV group (n=8) and HFOV group (n=8) by drawing lots, and they received ventilation in metered volume and HFOV treatment respectively. Heart blood was drawn from rabbits before they were sacrificed 4 hours after treatment to determine the plasma activity of lactate dehydrogenase 1 (LDH1) and creatine phosphorylated kinase (CPK-MB). Myocardial tissue from left ventricle was harvested and homogenized to determine the concentration of TNF-\u03b1 and 1L-8, the activity of caspase-1, and the activity of myosin-light-chain kinase (MLCK) and the ATPase of myosin light chain (MLC-ATPase) by enzyme-linked immunosorbent assay, spectrophotometry, and the nuclide liquid scintillation technique respectively. Part of the myocardial tissue sample was examined pathologically. Data were processed with analysis of variance. Results: (1) The activities of LDH1 and CPK-MB in plasma were obviously higher in CMV group than in HFOV group [(643\u00b1108), (342\u00b148) U vs. (233\u00b192), (186\u00b136) U, with F value respectively 10.326 and 9.846, P values all below 0.01]. (2) The contents of TNF-\u03b1, IL-8 and the activity of caspase-1 in myocardial tissue homogenate were obviously higher in CMV group than in HFOV group [(181\u00b135), (89\u00b119) pg/g, and (0.56\u00b10.27) g/g protein vs. (94\u00b121), (43\u00b111) pg/g, and (0.24\u00b10.12) g/g protein, with F value respectively 8.239, 7.826, 5.716, P values all below 0.01]. (3) The activities of MLC-ATPase and MLCK were lower in CMV group than in HFOV group [(0.24\u00b10.12) \u03bcmol\u00b7mg",
        "keywords": [
            "Burns",
            "Caspase 1",
            "Conventional mandatory ventilation",
            "High-frequency ventilation",
            "Inhalation",
            "Myocardium",
            "Myosin light chains",
            "Myosin-light-chain kinase"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2010,
        "id": "KVl4iPgj"
    },
    "GGoaiYho": {
        "authors": [
            {
                "name": "Chunli Wang",
                "org": "Department of Nephrology"
            },
            {
                "name": "Yang Wang",
                "org": "Department of Emergency"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Cardiology"
            },
            {
                "name": "Jing Xiong",
                "org": "Department of Nephrology"
            }
        ],
        "title": "A missense mutation of the \u03b1-galactosidase a gene in a chinese family of fabry disease with renal failure",
        "abstract": "Background: Fabry disease (FD) is a rare disease due to an X-linked recessive inborn error of glycosphingolipid metabolism resulting from the mutations of the \u03b1-galactosidase A (\u03b1-gal A) gene. FD is rare in Chinese and the data on clinic and genetic features of FD is still limited. Methods: In this study, the \u03b1-gal A gene of a Chinese family diagnosed with FD was analyzed for mutations and the genetic features of FD in this family were presented. Results: The \u03b1-gal A activity of the proband in this family was 0.03 nmol/ml/h in the whole blood. By PCR amplification and sequencing of the \u03b1-gal A gene exons, a single C-to-T transition was identified in codon 112 of exon 2. This C-to-T transition, mapping to position 334 in the cDNA of the \u03b1-gal A gene, was a missense mutation predicting a substitution of arginine to cysteine (p.R112C), which disrupts the normal activity of \u03b1-gal A enzyme. No further mutations were found in other exons of the \u03b1-gal A gene. In contrast to previous reports, in this family, all of the five male patients developed end-stage renal failure due to this missense mutation. Conclusions: These findings suggest that the missense mutation, p.R112C, in \u03b1-gal A gene ablates its activity and results in the development of FD with the renal damage. Copyright \u00a9 2013 S. Karger AG, Basel.",
        "keywords": [
            "Fabry disease",
            "Missense mutation",
            "Renal failure"
        ],
        "venue": "Kidney and Blood Pressure Research",
        "year": 2013,
        "id": "GGoaiYho"
    },
    "84Dyi04f": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Wen Chen",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Yan Peng",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Juan-Juan Xing",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Nian-Yun Wang",
                "org": "Department of Critical Care Medicine"
            }
        ],
        "title": "Effect of bone marrow-derived mesenchymal stem cells transplantation on the inflammatory response and lung injury in rabbit with inhalation injury",
        "abstract": "Objective: To study the effect of bone marrow-derived mesenchymal stem cells (MSC) transplantation on the major inflammatory cytokines content in peripheral blood, lung water mass fraction, and lung tissue injury in rabbits with smoke inhalation injury. Methods: Sixteen adult New Zealand big ear rabbits were subjected to smoke inhalation injury and then were divided into pure injury group (PI, n = 8) and MSC transplantation group (MT, n = 8) according to the random number table. Via ear marginal vein, rabbits in PI group were injected with 10 mL phosphate buffered saline (PBS) ; rabbits in MT group were injected with 10 mL PBS containing the third passage MSC (1 \u00d7 10 ",
        "keywords": [
            "Bone marrow-derived mesenchymal stem cells",
            "Burns",
            "Inflammatory cytokines",
            "Inhalation",
            "Lung injury",
            "Lung water mass fraction"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2010,
        "id": "84Dyi04f"
    },
    "ZHDcP0cK": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Guang-Hua Guo",
                "org": ""
            },
            {
                "name": "Song Huang",
                "org": ""
            },
            {
                "name": "Ren-Sheng Chen",
                "org": ""
            },
            {
                "name": "Wen Chen",
                "org": ""
            },
            {
                "name": "Jian-Hua Zhan",
                "org": ""
            }
        ],
        "title": "The effect of bone marrow mesenchymal stem cells engraftment on lung tissue at early stage of smoke inhalation injury in rabbits",
        "abstract": "Objective: To explore the effect of bone marrow mesenchymal stem cells (MSCs) engraftment on lung tissue at early stage of smoke inhalation injury in rabbits. Methods: MSCs were proliferated by the method of whole marrow culture and identified by flow cytometry. Forty-eight rabbits were randomly divided into smoke inhalation group (S group) and MSCs group (M group) after reproduction of rabbit smoke inhalation injury model. 10 ml of phosphate buffer saline (PBS) containing 1 \u00d7 10 ",
        "keywords": [
            "Bone marrow mesenchymal stem cell",
            "Lung injury",
            "Rabbit",
            "Smoke inhalation injury"
        ],
        "venue": "Chinese Critical Care Medicine",
        "year": 2011,
        "id": "ZHDcP0cK"
    },
    "bM4Cpf6L": {
        "authors": [
            {
                "name": "William Wei Jun Wang",
                "org": ""
            },
            {
                "name": "Cai Wei Xia",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Ze Zhang Zhu",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Shou Feng Wang",
                "org": ""
            },
            {
                "name": "Benson Hiu Yan Yeung",
                "org": ""
            },
            {
                "name": "Simon Kwong Man Lee",
                "org": ""
            },
            {
                "name": "Jack Chun Yiu Cheng",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Correlation of risser sign, radiographs of hand and wrist with the histological grade of iliac crest apophysis in girls with adolescent idiopathic scoliosis",
        "abstract": "Study Design.: A correlation analysis between histologic grade (HG) of iliac crest apophysis and skeletal age assessments. Objective.: To study the correlation between HGs of iliac crest apophysis and the skeletal age of hand and wrist, digital skeletal age (DSA), and Risser sign in the girls with adolescent idiopathic scoliosis (AIS). Summary of Background Data.: The evaluation of the remaining growth of the patients clinically and radiologically is highly significant in predicting the curve progression and thus influencing the treatment strategy in AIS. Methods.: Fifty-three AIS girls with a mean age of 14.0 years undergoing corrective posterior spinal surgery and instrumentation with autogenous bone graft were recruited. Menarche status was recorded while the skeletal age of hand and wrist, DSA, and Risser grade were evaluated radiologically. Using a standardized HG of proliferative chondrocyte zone of the iliac crest apophysis, correlation between the HGs and the radiologic and clinical skeletal maturity parameters was analyzed. Results.: The HGs were negatively correlated with the radiologic parameters with the highest correlation coefficient between HGs and skeletal age of hand and wrist. The negative correlation between HGs and the 2 clinical parameters was significant and could be enhanced by combining with the radiologic parameters. No proliferative chondrocyte zone of the apophysis was detected when patients were either over 16 years of skeletal age or Risser grade 5, as well as 2-year postmenarche or over 15 years of chronological age in patients with DSA stage III and Risser grade 4. Conclusion.: Radiologic skeletal age of the wrist and digits can provide important information for maturity assessment in girls with AIS. It can also enhance the sensitivity of clinical parameters in determining the remaining growth potential. \u00a9 2009 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Histology",
            "Idiopathic scoliosis",
            "Maturity",
            "Skeletal age measurement",
            "Wrist"
        ],
        "venue": "Spine",
        "year": 2009,
        "id": "bM4Cpf6L"
    },
    "iFeC9RmZ": {
        "authors": [
            {
                "name": "Jun Qiao",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Leilei Xu",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Zhen Liu",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery, Drum Tower Hospital, Nanjing University Medical School"
            }
        ],
        "title": "Inter- and intraobserver reliability assessment of the axial trunk rotation: Manual versus smartphone-aided measurement tools",
        "abstract": "Background: Scoliogauge, has been developed for the measurement of ATR on iPhone smartphones. This study was to evaluate the reliability for the smartphone-aided ATR measurement method and to compare its reliability with that of the manual method.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Axial trunk rotation",
            "Reliability",
            "Smartphone-aided measurement"
        ],
        "venue": "BMC Musculoskeletal Disorders",
        "year": 2014,
        "id": "iFeC9RmZ"
    },
    "ny3YX1KA": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Guang-Hua Guo",
                "org": ""
            },
            {
                "name": "Jian-hua Zhan",
                "org": ""
            },
            {
                "name": "An Xie",
                "org": ""
            }
        ],
        "title": "Screening of optimal labeling time and labeling concentration of rabbit bone marrow mesenchymal stem cells by 5-bromodeoxyuridine in vitro",
        "abstract": "BACKGROUND: Currently, bone marrow mesenchymal stem cells (BMSCs) are potential cells and host cells for gene therapy.Labeling in vitro is a premise to track their survival, \"homing\", growth, differentiation and so on. OBJECTIVE: To explore the optimal 5-bromodeoxyuridine (BrdU) concentration and time of labeling for rabbit BMSCs in vitro. METHODS: Rabbit BMSCs were harvested from bone marrow of purebred healthy New Zealand white rabbits. BMSCs were identified by flow cytometry and morphology. Rabbit BMSCs-labeling positive rates using BrdU at different concentrations and different incubation time were observed. RESULTS AND CONCLUSION: Flow cytometry finally confirmed that the cells we cultured were BMSCs combined with morphological observation; the growth curve of rabbit MSCs was \"S\" shape. The positive rate of BMSCs labeled by BrdU increased with incubation time and BrdU concentration, and more than 85%-95% BMSCs were labeled after at optimal 40 \u03bcmol/Land 72 hours. Above-mentioned results have suggested that application of BrdU labeling for BMSCs in vitro is safe and reliable.The optimal time and concentration for labeling BMSCs are 72 hours and 40 \u03bcmol/L.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2010,
        "id": "ny3YX1KA"
    },
    "DpHtc3hD": {
        "authors": [
            {
                "name": "Min Wang",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Feng Peng",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Rui Tian",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Chengjian Shi",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Meng Xu",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Xu Li",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Xin Wang",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Ming Shen",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            },
            {
                "name": "Renyi Qin",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Huazhong University of Science and Technology"
            }
        ],
        "title": "Greater omentum binding: A simple technique to cover the pancreatic remnant after distal pancreatectomy",
        "abstract": "",
        "keywords": [
            "Abbreviations and Acronyms",
            "distal pancreatectomy",
            "DP",
            "GO",
            "greater omentum",
            "International Study Group on Pancreatic Fistula",
            "ISGPF",
            "pancreatic fistula",
            "PF",
            "POPF",
            "postoperative pancreatic fistula"
        ],
        "venue": "Journal of the American College of Surgeons",
        "year": 2014,
        "id": "DpHtc3hD"
    },
    "DhFxn0zy": {
        "authors": [
            {
                "name": "Jian Cheng",
                "org": ""
            },
            {
                "name": "Shu Yuan",
                "org": ""
            },
            {
                "name": "Zhong-Wei Zhang",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "He Tang",
                "org": ""
            },
            {
                "name": "Fei Xu",
                "org": ""
            },
            {
                "name": "Hong Feng",
                "org": ""
            },
            {
                "name": "Huang-Fan Xie",
                "org": ""
            },
            {
                "name": "Wei-Lin Xu",
                "org": ""
            },
            {
                "name": "Hong-Hui Lin",
                "org": ""
            }
        ],
        "title": "Plastid-signalling-mediated anthocyanin accumulation in mature Arabidopsis rosettes",
        "abstract": "Genetic and physiological studies have revealed evidences for multiple signaling pathways by which the plastid exerts retrograde control over photosynthesis-associated-nuclear-genes (PhANGs). Recently, more and more studies showed that plastid signals affected more cellular processes other than PhANGs repression. Previous reports indicated that the herbicide norflurazon (NF)-derived signals, sugar signals and plastid gene expression (PGE)-derived signals all regulated anthocyanin accumulation and early anthocyanin biosynthesis gene expression in newly-germinated seedlings. In the research, we found that these signals also work as well for anthocyanin biosynthesis genes in mature Arabidopsis seedlings. Sugar/PGE signals doubled leaf total anthocyanins within 48 h (accumulated at the base of petiole), while NF signals induced a little anthocyanin accumulation (about 30 % and invisible to the naked eye). The plastid hexokinase (pHXK) participates in sugar/PGE signalling, while the plastid Genomes uncoupled protein 1 (GUN1) and the nuclear ABA-insensitive transcription factor 4 (ABI4) are involved in both sugar/PGE signalling and NF-derived signalling. \u00a9 2012 Springer Science+Business Media B.V.",
        "keywords": [
            "ABA-insensitive transcription factor 4 (ABI4)",
            "Anthocyanin",
            "Genomes uncoupled protein 1 (GUN1)",
            "Plastid hexokinase",
            "Plastid signalling"
        ],
        "venue": "Plant Growth Regulation",
        "year": 2012,
        "id": "DhFxn0zy"
    },
    "GDE1NLAD": {
        "authors": [
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            }
        ],
        "title": "Variations of the position of the cerebellar tonsil in idiopathic scoliotic adolescents with a cobb angle >40\u00b0: A magnetic resonance imaging study",
        "abstract": "STUDY DESIGN. A retrospective study was performed through measurements on MRI images in adolescent idiopathic scoliosis (AIS) patients and age-matched adolescents. OBJECTIVES. To investigate the position of the cerebellar tonsil in AIS patients with a Cobb angle >40\u00b0 in comparison with age-matched healthy adolescents and to determine the relationships of the tonsil position with age, sex, curve severity, and curve patterns. SUMMARY OF BACKGROUND DATA. There have been increasing evidences implying that AIS patients may present with subtle or subclinical neurologic dysfunction and a higher incidence of tonsillar ectopia was documented in AIS patients. However, the tonsil position has not been clearly addressed in AIS patients with a severe curve. METHODS. According to the method described by Aboulezz et al, measurements of the tonsil position relative to the magnum foramen on magnetic resonance images were performed in 203 AIS patients with a Cobb angle >40\u00b0 and 86 age-matched healthy adolescents. The inferior displacement of the cerebellar tonsil with an extent within 5 mm was defined as tonsillar ectopia when it located below the magnum foramen. On the basis of measurement results, the incidence of tonsillar ectopia was determined in both AIS and control groups. The associations of tonsillar ectopia with curve severity and curve patterns for AIS patients and the relationships of the tonsil positions with age and gender in all subjects were analyzed. RESULTS. In AIS patients and healthy controls, the median position of the cerebellar tonsil was 0.8 and 2.9 mm above the magnum foramen, respectively. The incidence of tonsillar ectopia (0-4.8 mm below the magnum foramen) in AIS was found to be significantly higher than healthy adolescents (range 0-1.8 mm vs. 0-4.8 mm below the magnum foramen; ratio 34.5% vs. 5.8%; P < 0.01). No significant correlations were found between the position of the cerebellar tonsil with age or gender in AIS and control subjects. It was shown the position of the cerebellar tonsil was not significantly different among AIS patients with different curve severity. However, it was noted that there was a highest incidence (62.5%) of tonsillar ectopia in atypical scoliotic cases with a double thoracic curve. Additionally, a significantly higher incidence of tonsillar ectopia was found in patients with thoracic or thoracolumbar curves when compared with those with lumbar curves (37.4% vs. 21.6%, P = 0.049). CONCLUSION. Tonsillar ectopia with the extent >2 mm in AIS patients should be regarded as abnormal. AIS patients had a lower tonsil position and a higher prevalence of tonsillar ectopia than controls, and tonsillar ectopia was found to be associated with curve patterns. It is suggested that a lower position of the cerebellar tonsil might be associated with the etiopathogenesis of AIS and might contribute to subclinical neurologic dysfunction in AIS patients. \u00a9 2007 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Adolescent",
            "Cerebellar tonsil",
            "Etiopathogenesis",
            "Idiopathic scoliosis",
            "MRI",
            "Tonsillar herniation"
        ],
        "venue": "Spine",
        "year": 2007,
        "id": "GDE1NLAD"
    },
    "lOZ9YGQM": {
        "authors": [
            {
                "name": "Yongxiong He",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Quantitative analysis of types i and II collagen in the disc annulus in adolescent idiopathic scoliosis",
        "abstract": "Objective: To find the possible roles of collagen in the pathogenesis of AIS through studies of the distribution of the collagen I and II in the disc annulus fibrous in adolescent idiopathic scoliosis (AIS). Methods: The disc annulus fibrous of apex curve were harvested during anterior surgery and divided into concave and convex samples. 25 AIS cases were covered in this study including 6 males and 19 females, with an average age of 14.6 years (range 12-18years). 11 specimens were intervertebral disc from the thoracic region (from T8 to T11) and 14 sample were from lumbar discs (from L1 to L2). RT-PCR was employed to investigate the distribution and content of collagen I (220bp) and collagen II (359bp) in the intervertebral disc specimens. 1% agarose gel electrophoresis and the Gelwork image analysis system was used in the semi-quantitative analysis of the product. Results: For the AIS group, type I collagen and type II collagen significantly increased on convex side compared with that of the concave side (p<0.01). The same trend was observed in both thoracic and lumber disc annulus fibrosis, but there was no statistical difference expect for the expression of type II collagen in convex side of disc annulus fibrous (p<0.05). Conclusion: The asymmetric expression of collagen I and II collagen showing that there was degeneration in the intervertebral disc of AIS. The abnormal collagen metabolism may be one of reasons in the development of AIS and probably an important factor in the progression of AIS. \u00a9 2006 The authors. All rights reserved.",
        "keywords": [
            "Intervertebral Disc",
            "Scoliosis",
            "Type I Collage",
            "Type II Collagen"
        ],
        "venue": "Studies in Health Technology and Informatics",
        "year": 2006,
        "id": "lOZ9YGQM"
    },
    "eeMQqeyC": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Wen Chen",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Nian-Yun Wang",
                "org": "Department of Critical Care Medicine"
            }
        ],
        "title": "Effects of bone marrow-derived mesenchymal stem cells engraftment on VEGF in lung tissue and in plasma of rabbits at early stage of smog inhalation injury",
        "abstract": "Objective To discuss the effects of bone marrow-derived mesenchymal stem cells (MSCs) on vascular endothelial growth factor (VEGF) in lung tissue and in plasma,and extra-vascular lung water at the early stage of smog inhalation injury. Method The rabbit model of smog inhalation injury was established by using home-made smog generator, and the rabbit models were randomly ( random number) divided into control group (group S, n = 32) and MSCs treatment group (group M, n = 32). Ten mL phosphate-buffered saline (PBS) was injected into ear marginal vein immediately after injury in rabbits of group S. The third generation of MSCs 1/10/ 10 mL PBS was injected into ear marginal vein immediately after injury in rabbits of group M. The levels of VEGF in peripheral blood and lung tissue were measured 0 h,2 h,4 h and 6 hours after injection respectively, and analyzed . The right lung of rabbits was taken out to measure and calculate lung water mass fraction after experiment. Results In lung tissue, the levels of VEGF decreased gradually in group S(P < 0.05), and though the levels of VEGF in lung tissue appeared with significant decreasing trend in group M(P < 0.05), they were still higher than those of group S at corresponding intervals (P < 0.05). In peripheral blood, the levels of VEGF increased gradually in group S (P < 0.05), and the levels of VEGF in group M appeared with markedly increasing trend (P < 0.05), but they were lower significantly than those in group S at corresponding intervals ( P < 0.05). Conclusions MSCs engraftment to the rabbits with smog inhalation injury could increase VEGF in lung tissue, decrease VEGF in plasma and reduce extra-vascular lung water, showing protective effect on smog inhalation injury to a certain extent.",
        "keywords": [
            "Extravascular lung water",
            "Mesenchymal stem cells",
            "Rabbit",
            "Smoke inhalation injury",
            "Vascular endothelial cell growth factor"
        ],
        "venue": "Chinese Journal of Emergency Medicine",
        "year": 2010,
        "id": "eeMQqeyC"
    },
    "vZwyRPn7": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "De-Hui Xi",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Xing-Guang Deng",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Xing-Ji Peng",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "He Tang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Ying-Juan Chen",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Wei Jian",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Hong Feng",
                "org": "Chengdu Normal College"
            },
            {
                "name": "Hong-Hui Lin",
                "org": "State Key Laboratory of Hydraulics and Mountain River Engineering"
            }
        ],
        "title": "The Chilli Veinal Mottle Virus Regulates Expression of the Tobacco Mosaic Virus Resistance Gene N and Jasmonic Acid/Ethylene Signaling Is Essential for Systemic Resistance Against Chilli Veinal Mottle Virus in Tobacco",
        "abstract": "Genetic, physiological, and molecular analyses have revealed that the stress-related phytohormones salicylic acid (SA), jasmonic acid (JA), and ethylene (ET) are known to participate in defense responses to mitigate biotic stress in plants. Recent evidence suggests that N-gene (a typical resistance gene) transcription is upregulated by Tobacco mosaic virus (TMV) infection, which is specifically a TMV-related phenomenon. In this study, we investigated N-gene transcription in tobacco",
        "keywords": [
            "Chilli veinal mottle virus (ChiVMV)",
            "Ethylene (ET)",
            "Jasmonic acid (JA)",
            "N gene",
            "Salicylic acid (SA)",
            "Virus-induced gene-silencing (VIGS)"
        ],
        "venue": "Plant Molecular Biology Reporter",
        "year": 2014,
        "id": "vZwyRPn7"
    },
    "dW7xCoLn": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Xiong He",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Wei Jun Wang",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "The anatomical relationship between the aorta and the thoracic vertebral bodies and its importance in the placement of the screw in thoracoscopic correction of Scoliosis",
        "abstract": "Thoracoscopically-assisted anterior spinal instrumentation is being used widely to treat adolescent idiopathic scoliosis (AIS). Recent studies have showed that screws placed thoracoscopically could counter the aorta or entrance into the spinal canal. There are a few studies defining the anatomic landmarks to identify the relationship between the aorta and the thoracic vertebral body using quantitative measurement for the sake of safe placement of thoracoscopic vertebral screw in anterior correction for AIS. The CT scanning from T4 to T12 in 64 control subjects and 30 AIS patients from mainland China were analyzed manually. Parameters to be measured included the angle for safety screw placement (\u03b1), the angle of the aorta relative to the vertebral body (\u03b2), the distance from the line between the left and the right rib heads to the anterior wall of the vertebral canal (a), the distance from the left rib head to posterior wall of the aorta (b), the vertebral body transverse diameter (c) and vertebral rotation (\u03b3). No significant differences were found between the groups with respect to age or sex. Compared with the control group, \u03b1 angle from T7 to T10, \u03b2 angle from T5 to T10 and b value at T9, T10 were significantly lower in the scoliotic group. The a value was significantly lower in the scoliotic group. The c value showed no significant difference between the two groups. In conclusion, to place the thoracoscopic vertebral screw safely, at the cephalad thoracic spine (T4-T6), the maximum ventral excursion angle should decrease gradually from 20\u00b0 to 5\u00b0, the entry-point of the screw should be close to the rib head. For apical vertebrae (T7-T9), the maximum ventral excursion angle increased gradually from 5\u00b0 to 12\u00b0. At the caudal thoracic spine (T10-T12), the maximum ventral excursion angle increased, the entry-point should shift 3-5 mm ventrally. \u00a9 2007 Springer-Verlag.",
        "keywords": [
            "Anatomy",
            "Aorta",
            "Scoliosis",
            "Thoracic vertebrae",
            "Thoracoscopy"
        ],
        "venue": "European Spine Journal",
        "year": 2007,
        "id": "dW7xCoLn"
    },
    "JRzNGYiC": {
        "authors": [
            {
                "name": "Rongrong Nie",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Feng Zhu",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Liru Shen",
                "org": "Southwestern Institute of Physics"
            },
            {
                "name": "Zhiqing Chen",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Xiaoyu Li",
                "org": "Key Lab. of Oral Biomedical Engineering"
            },
            {
                "name": "Xia Deng",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Gang He",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Yong Zhao",
                "org": "West China College of Stomatology"
            },
            {
                "name": "Zhihong Liang",
                "org": "West China College of Stomatology"
            }
        ],
        "title": "Structure and in vitro bioactivity of Si enriched hydroxyapatite/ TiO 2 coatings on pure titanium by micro-arc oxidation",
        "abstract": "The effect of Si doping on the bioactivity and characteristics of hydroxyapatite/TiO",
        "keywords": [
            "Cytocompatibility",
            "Micro-arc oxidation",
            "Silicon",
            "Simulated body fluid"
        ],
        "venue": "Key Engineering Materials",
        "year": 2007,
        "id": "JRzNGYiC"
    },
    "oQQ2rrL1": {
        "authors": [
            {
                "name": "Tao Wu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            },
            {
                "name": "Huang Yan",
                "org": "Spine Surgery"
            },
            {
                "name": "Xin Zheng",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Winnie Chu",
                "org": "Department of Diagnostic Radiology and Organ Imaging"
            },
            {
                "name": "Jack C.Y. Cheng",
                "org": "Nanjing University"
            },
            {
                "name": "Yong Qiu",
                "org": "Nanjing University"
            }
        ],
        "title": "Is curve direction correlated with the side of dominant displacement of cerebellar tonsil and syrinx deviation in thoracic scoliosis secondary to Chiari malformation type I and syringomyelia?",
        "abstract": "The patho-mechanism of scoliosis in patients with syringomyelia (SM) secondary to Chiari malformation type I (CMI) remains unknown up till now. In small sample studies published recently, there was an observation that curve direction tended to be on the same side as the dominant side of tonsillar displacement or the deviated side of syrinx location. Herein, a large-sample study of patients with single thoracic scoliosis secondary to CMI and SM was performed to validate these findings. The clinical and radiographic data of patients with scoliosis secondary to SM and CMI were reviewed. And patients who met the inclusion criteria were included. Based on the imaging presentation, the asymmetry of tonsillar displacement, syrinx location and scoliosis were judged by quantitative method. Then the imaging association among asymmetrically displaced tonsil, eccentrically located syrinx and curve direction were further analyzed. Thirty-nine patients with single thoracic scoliosis secondary to CMI and SM were included. 80% subjects showed concordance between the deviated side of eccentrically located syrinx and the dominant side of asymmetrically displaced tonsil. In 86% patients with asymmetrically displaced tonsil, thoracic curve was convex to the dominant side of tonsillar displacement. In 68% of patients with eccentrically located syrinx, the convex side of thoracic curve was on the same side as the deviated side of syrinx location. Asymmetrically displaced tonsils and eccentrically located syrinx are common imaging presentations in patients with SM secondary to CMI. The thoracic scoliosis in these patients was usually convex not only to the dominant side of asymmetrically displaced tonsils, but also to the side of eccentrically located syrinx, indicating that the asymmetry of tonsillar displacement and syrinx location might be involved in the regulation of curve direction. \u00a9 2012 The authors and IOS Press. All rights reserved.",
        "keywords": [
            "Asymmetry",
            "Chiari malformation Type I (CMI)",
            "Scoliosis",
            "Syrinx"
        ],
        "venue": "Studies in Health Technology and Informatics",
        "year": 2012,
        "id": "oQQ2rrL1"
    },
    "uwHTGdsP": {
        "authors": [
            {
                "name": "Zhihua Qiu",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Xiao Chen",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yanzhao Zhou",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Jibin Lin",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Dan Ding",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Shijun Yang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Fen Chen",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Min Wang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Feng Zhu",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Xian Yu",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Zihua Zhou",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yuhua Liao",
                "org": "Laboratory of Cardiovascular Immunology"
            }
        ],
        "title": "Therapeutic Vaccines against Human and Rat Renin in Spontaneously Hypertensive Rats",
        "abstract": "Vaccination provides a promising approach for treatment of hypertension and improvement in compliance. As the initiation factor of renin-angiotensin system, renin plays a critical role in hypertension. In this study, we selected six peptides (rR32, rR72, rR215, hR32, hR72, and hR215) belonging to potential epitopes of rat and human renin. The main criteria were as follows: (1) include one of renin catalytic sites or the flap sequence; (2) low/no-similarity when matched with the host proteome; (3) ideal antigenicity and hydrophilicity. The peptides were coupled to keyhole limpet hemocyanin and injected into SpragueDawley (SD) rats, spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats. The antisera titers and the binding capacity with renin were detected. The effects of the anti-peptides antibodies on plasma renin activity (PRA) and blood pressure were also determined. All peptides elicited strong antibody responses. The antisera titers ranged from 1:32,000 to 1:80,000 in SD rats on day 63. All antisera could bind to renin in vitro. Compared with the control antibody, the antibodies against the rR32, hR32, rR72 and hR72 peptides inhibited PRA level by up to about 50%. Complete cross-reactivity of the anti-rR32 antibody and the anti-hR32 antibody was confirmed. The epitopes rR32 and hR32 vaccines significantly decreased systolic blood pressure (SBP) of SHRs up to 15mmHg (175\u00b12 vesus 190\u00b13 mmHg, P = 0.035; 180\u00b12 vesus 195\u00b13 mmHg, P = 0.039), while no obvious effect on SD rats. Additionally, no significant immune-mediated damage was detected in the vaccinated animals. In conclusion, the antigenic peptide hR32 vaccine mimicking the ",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2013,
        "id": "uwHTGdsP"
    },
    "hhKNxVVn": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "School of Biomedical Engineering"
            },
            {
                "name": "Binjie Qin",
                "org": "School of Biomedical Engineering"
            },
            {
                "name": "Weiyue Feng",
                "org": "CAS Key Laboratory of Nuclear Analytical Techniques"
            },
            {
                "name": "Huajian Wang",
                "org": "CAS Key Laboratory of Nuclear Analytical Techniques"
            },
            {
                "name": "Shaosen Huang",
                "org": "School of Biomedical Engineering"
            },
            {
                "name": "Yisong Lv",
                "org": "Department of Mathematics"
            },
            {
                "name": "Yong Chen",
                "org": "School of Mechanical Engineering"
            }
        ],
        "title": "Reducing Poisson noise and baseline drift in x-ray spectral images with bootstrap Poisson regression and robust nonparametric regression",
        "abstract": "X-ray spectral imaging provides quantitative imaging of trace elements in a biological sample with high sensitivity. We propose a novel algorithm to promote the signal-to-noise ratio (SNR) of x-ray spectral images that have low photon counts. Firstly, we estimate the image data area that belongs to the homogeneous parts through confidence interval testing. Then, we apply the Poisson regression through its maximum likelihood estimation on this area to estimate the true photon counts from the Poisson noise corrupted data. Unlike other denoising methods based on regression analysis, we use the bootstrap resampling method to ensure the accuracy of regression estimation. Finally, we use a robust local nonparametric regression method to estimate the baseline and subsequently subtract it from the x-ray spectral data to further improve the SNR of the data. Experiments on several real samples show that the proposed method performs better than some state-of-the-art approaches to ensure accuracy and precision for quantitative analysis of the different trace elements in a standard reference biological sample. \u00a9 2013 Institute of Physics and Engineering in Medicine.",
        "keywords": [
            ""
        ],
        "venue": "Physics in Medicine and Biology",
        "year": 2013,
        "id": "hhKNxVVn"
    },
    "jCrxsvRB": {
        "authors": [
            {
                "name": "Jin Zhou",
                "org": "Department of Neurology"
            },
            {
                "name": "Guoping Tian",
                "org": "Department of Neurology"
            },
            {
                "name": "Jing'e Wang",
                "org": "Department of Neurology"
            },
            {
                "name": "Xuefeng Cong",
                "org": "Department of Neurology"
            },
            {
                "name": "Xingkai Wu",
                "org": "Department of Neurology"
            },
            {
                "name": "Siyang Zhang",
                "org": "China Medical University"
            },
            {
                "name": "Li Li",
                "org": "Department of Neurology"
            },
            {
                "name": "Bing Xu",
                "org": "Department of Neurology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Neurology"
            },
            {
                "name": "Xuedan Luo",
                "org": "Department of Neurology"
            },
            {
                "name": "Jian Han",
                "org": "Department of Neurology"
            },
            {
                "name": "Fengjie Hu",
                "org": "Department of Neurology"
            }
        ],
        "title": "In vitro differentiation of adipose-derived stem cells and bone marrow-derived stromal stem cells into neuronal-like cells",
        "abstract": "Adipose-derived stem cells and bone marrow-derived stromal stem cells were co-cultured with untreated or A\u03b2",
        "keywords": [
            "Adipose-derived stem cells",
            "Bone marrow-derived stromal stem cells",
            "Differentiation",
            "Mir-125a-3p",
            "Neural regeneration",
            "Neuron"
        ],
        "venue": "Neural Regeneration Research",
        "year": 2011,
        "id": "jCrxsvRB"
    },
    "T1qVWkeW": {
        "authors": [
            {
                "name": "Yan-Xiang Sun",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Hai-Yan Zhang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yu-Miao Wei",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Feng Zhu",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Min Wang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Yu-Hua Liao",
                "org": "Laboratory of Cardiovascular Immunology"
            }
        ],
        "title": "The mechanism of signal transduction during vascular smooth muscle cell proliferation induced by autoantibodies against angiotensin AT1 receptor from hypertension",
        "abstract": "Background: Autoantibodies against angiotensin AT1 receptor have been discovered in patients with preeclampsia or malignant hypertension. Some studies have demonstrated that the autoantibodies are involved in the immunopathogenesis of hypertension and have an agonist effect similar to angiotensin II. Methods: Autoantibodies against AT1 receptor were purified from sera of patients with primary hypertension by affinity chromatography. Proliferation of cultured rat vascular smooth muscle cells was detected by bromodeoxyuridine incorporation and activation of signalling molecules detected by Western-blotting and electrophoretic mobility shift assay. Results: The AT1-RAb caused a significant proliferation similar to the Ang 11 during first 24 hours. The levels of nuclear factor-\u03baB (NF-\u03baB), phosphorylated JAK2, phosphorylated STAT1 (pSTAT1) and phosphorylated STAT3 (pSTAT3) molecules were increased in response to the autoantibodies. In contrast, the activations of NF-\u03baB and JAK-STAT were blocked by losartan, pyrrolidinedithiocarbamate (a specific inhibitor of NF-\u03baB) and AG490 (a specific inhibitor of the JAK2 tyrosine kinase). The expressions of NF-\u03baB, pSTAT1 and pSTAT3 reached peak levels at different times. Moreover, the relative densities of electrophoretic bands showed that activation of pSTAT3 was more significant than STAT1 induced by AT1-RAb. Conclusions: These results suggest that the autoantibodies against AT1 receptor have an agonist effect similar to Ang II in proliferatlon of VSMCs and the NF-\u03baB and JAK-STAT proteins play essential roles. The effect is different from Angll in that STAT3 is the main downstream activating molecule in JAK-STAT signalling pathway.",
        "keywords": [
            "Activation of transcription",
            "Angiotensin AT1 receptor",
            "Autoantibody",
            "Janus kinase-signal transduction",
            "nuclear factor-\u03baB",
            "Proliferation"
        ],
        "venue": "Chinese Medical Journal",
        "year": 2008,
        "id": "T1qVWkeW"
    },
    "RD0GoDT1": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Jun Qiao",
                "org": ""
            },
            {
                "name": "Xusheng Qiu",
                "org": ""
            },
            {
                "name": "Leilei Xu",
                "org": ""
            },
            {
                "name": "Zhen Liu",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Bangping Qian",
                "org": ""
            },
            {
                "name": "Xu Sun",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Lack of association between suppressor of cytokine signaling-3 gene polymorphism and susceptibility and curve severity of adolescent idiopathic scoliosis",
        "abstract": "Purpose To explore whether the suppressor of cytokine signaling-3 (SOCS3) gene polymorphisms are associated with the susceptibility and abnormal growth pattern of adolescent idiopathic scoliosis (AIS). Methods Three hundred and ninety eight AIS girls aged 10-18 years old were enrolled, and 367 age-matched healthy girls were recruited as controls. Only patients who had Cobb angles larger than 20",
        "keywords": [
            "Abnormal growth pattern",
            "Adolescent idiopathic scoliosis",
            "Suppressor of cytokine signaling-3",
            "Susceptibility"
        ],
        "venue": "European Spine Journal",
        "year": 2014,
        "id": "RD0GoDT1"
    },
    "PqZcom2p": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Moyun Xu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Shaodong Wang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Shudan Jia",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Ping Zhang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Honghui Lin",
                "org": "State Key Laboratory of Hydraulics and Mountain River Engineering"
            },
            {
                "name": "Dehui Xi",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            }
        ],
        "title": "Prokaryotic expression of pathogenesis related protein 1 gene from Nicotiana benthamiana: Antifungal activity and preparation of its polyclonal antibody",
        "abstract": "The nucleotide sequence of the pathogenesis-related protein 1(PR-1) gene was obtained from Nicotiana benthamiana using RT-PCR. Restriction enzyme cutting sites of EcoRI and NotI were introduced to the ORF fragments of PR-1, they were then linked together with pET-30a (+) and transformed into E. coli BL21 (DE3). The target protein was induced by 1. 5 mM IPTG, at 37\u00b0C for 4 h. The expressed protein was purified by Ni-NTA and an anti-NbPR-1 polyclonal antibody was prepared using rabbits. The antibody could detect the expression of PR-1 in N. benthamiana and other Nicotiana plants. NbPR-1 protein has four \u03b1-helices and two \u03b2-sheets by homology modeling. Furthermore, the purified NbPR-1 protein exhibited a broad-spectrum antifungal activity. \u00a9 2012 Springer Science+Business Media B.V.",
        "keywords": [
            "Antifungal activity",
            "Nicotiana benthamiana",
            "Pathogenesis-related protein 1",
            "Polyclonal antibody",
            "Prokaryotic expression",
            "Protein structure"
        ],
        "venue": "Biotechnology Letters",
        "year": 2012,
        "id": "PqZcom2p"
    },
    "S16qyBXN": {
        "authors": [
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Tao Wu",
                "org": "Department of Orthopedics"
            },
            {
                "name": "Shifu Sha",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Is curve direction correlated with the dominant side of tonsillar ectopia and side of syrinx deviation in patients with single thoracic scoliosis secondary to chiari malformation and syringomyelia?",
        "abstract": "STUDY DESIGN.: A retrospective imaging study. OBJECTIVE.: To conduct an assessment of the correlation of the coronal asymmetries between tonsillar ectopia, syrinx, and scoliosis. SUMMARY OF BACKGROUND DATA.: A few reports have shown that the convex side of scoliosis was on the same side as the dominant tonsillar ectopia or syrinx deviation in a majority of patients. However, this issue remains controversial. METHODS.: A retrospective study was conducted on young patients with a single thoracic scoliosis secondary to Chiari malformation type I and syringomyelia. The curve direction, side of the dominant tonsillar ectopia and side of the syrinx deviation were recorded and assessed quantitatively. The correlations between the asymmetrically displaced tonsils, eccentrically located syrinx, and curve convexity were investigated. RESULTS.: A total of 39 patients were included. The concordance between the deviated side of the eccentrically located syrinx and dominant side of the asymmetrically displaced tonsils was 87.0%. In 88.5% of the patients with an asymmetrically displaced tonsil, the convex side of the scoliosis was concordant with the dominant side of the tonsillar ectopia, and in 86.2% of patients with an eccentrically located syrinx, the convex side of the scoliosis was on the same side as the deviated side of the syrinx. In addition, the dominant tonsillar ectopia, syrinx deviation, and curve direction were all on the same side in 82.6% patients with asymmetrically displaced tonsils and eccentrically located syrinx. CONCLUSION.: Asymmetrically displaced tonsils and eccentrically located syrinxes were common imaging features in these patients. The thoracic spine tended to be convex to not only the dominant side of the asymmetrically displaced tonsil, but also the deviated side of the eccentrically located syrinx. The effect of syrinx deviation on curve convexity is similar to that of dominant tonsillar ectopia in the majority of patients. \u00a9 2013, Lippincott Williams & Wilkins.",
        "keywords": [
            "asymmetry",
            "Chiari malformation type I (CMI)",
            "scoliosis",
            "syrinx"
        ],
        "venue": "Spine",
        "year": 2013,
        "id": "S16qyBXN"
    },
    "t8mhp9IR": {
        "authors": [
            {
                "name": "Xu-Sheng Qiu",
                "org": "Medical School"
            },
            {
                "name": "Wei-Wei Ma",
                "org": "Medical School"
            },
            {
                "name": "Wei-Guo Li",
                "org": "Medical School"
            },
            {
                "name": "Bin Wang",
                "org": "Medical School"
            },
            {
                "name": "Yang Yu",
                "org": "Medical School"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Medical School"
            },
            {
                "name": "Bang-Ping Qian",
                "org": "Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Medical School"
            },
            {
                "name": "Xu Sun",
                "org": "Medical School"
            },
            {
                "name": "Bobby K. W. Ng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Jack C. Y. Cheng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Yong Qiu",
                "org": "Joint Scoliosis Research Center"
            }
        ],
        "title": "Discrepancy between radiographic shoulder balance and cosmetic shoulder balance in adolescent idiopathic scoliosis patients with double thoracic curve",
        "abstract": "Shoulder balance is one of the key components to the body deformity in adolescent idiopathic scoliosis (AIS) patients with double thoracic curve and shoulder cosmesis plays an important role in patients' satisfaction of surgical outcomes. Up to now, only radiographic parameters were used to evaluate the shoulder balance in literatures; no corresponding cosmetic parameters have been developed to evaluate the cosmetic shoulder balance. Meanwhile, we often confronted that perfect radiographic shoulder balance was achieved, but the patients complained about the residual cosmetic deformity. This phenomenon implied that discrepancy may exist between radiographic shoulder balance and cosmetic shoulder balance. The present study was carried out to investigate the correlation between radiographic and clinical cosmetic shoulder balance in AIS patients with double thoracic curve. Thirty-four AIS patients were recruited for this study. All the patients had a double thoracic curve. Six cosmetic parameters - inner shoulder height (SHi), outer shoulder height (SHo), shoulder area index 1 (SAI1), shoulder area index 2 (SAI2), shoulder angle (\u03b11) and axilla angle (\u03b12) were developed and measured on the standing photographs. Also, seven radiographic parameters - T1 tilting (T1), first rib angle (FRA), clavicle angle (CA), coracoid process height (CPH), clavicle-rib cage intersection (CRCI), first rib-clavicle height (FRCH), trapezius length (TL) were measured on the standing posterior-anterior radiographs. Correlation analysis was made between cosmetic parameters and radiographic parameters. SHi was found to be significantly correlated with T1, FRA, CA, CPH, CRCI (P < 0.05), among which FRA had the highest correlation coefficient. SHo was found to be significantly correlated with T1, FRA, CA, CPH, CRCI, FRCH (P < 0.05), among which CRCI had the highest correlation coefficient. However, none of the correlation coefficient was greater than 0.8. The correlation coefficients between radiographic parameters and SAI1, SAI2, \u03b11, \u03b12 were also below 0.8 that were similar with SH. The results indicated that radiographic parameters could only partially reflect the shoulder cosmetic appearances. However, none of the existing parameters can accurately reflect the shoulder cosmetic appearance. As cosmesis is critical important to patients' satisfaction, spine surgeons should pay more attention to the cosmetic shoulder balance rather than radiographic shoulder balance. \u00a9 2008 Springer-Verlag.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Cosmesis",
            "Double thoracic curve",
            "Radiographic"
        ],
        "venue": "European Spine Journal",
        "year": 2009,
        "id": "t8mhp9IR"
    },
    "B38uJydb": {
        "authors": [
            {
                "name": "Shoufeng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhaolong Ma",
                "org": "Spine Surgery"
            },
            {
                "name": "Caiwei Xia",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Expression of Runx2 and type X collagen in vertebral growth plate of patients with adolescent idiopathic scoliosis",
        "abstract": "The different expression of type X collagen and Runx2 between the convex and concave side of vertebral growth plate in scoliosis may help to improve our understanding of the role that growth plate tissue play in the development or progression of idiopathic scoliosis. In this investigation, there were significant differences of the total expression of type X collagen, Runx2 protein, and Runx2 mRNA between convex side and concave side growth plates of the apex vertebrae (p < 0.05). The total expression of type X collagen in the concave side growth plates of the lower end vertebrae was higher than that in the same side growth plates of apex (p < 0.05). The total expression of Runx2 in the concave side growth plates in the upper and lower end vertebrae were higher than that in the concave side growth plates of apex (p < 0.05). The expression of type X collagen, Runx2, and Runx2 mRNA, the cell density of type X collagen and Runx2 positive chondrocytes, and histological changes between convex side and concave side of the vertebral growth plate indicated that the vertebral growth plate was affected by mechanical forces, which was a secondary change and could contribute to progression of adolescent idiopathic scoliosis. \u00a9 2010 Informa UK Ltd.",
        "keywords": [
            "Condrocytes",
            "Growth Plate",
            "Idiopathic Scoliosis",
            "Runx2",
            "Type X Collagen"
        ],
        "venue": "Connective Tissue Research",
        "year": 2010,
        "id": "B38uJydb"
    },
    "JhgbdyRt": {
        "authors": [
            {
                "name": "Tingzhe Sun",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University"
            },
            {
                "name": "Ruoshi Yuan",
                "org": "Laboratory for Biocomputing and Bioinformatics, Department of Computer Science and Engineering, Shanghai Jiao Tong University"
            },
            {
                "name": "Wei Xu",
                "org": "Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Jiao Tong University"
            },
            {
                "name": "Feng Zhu",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University"
            },
            {
                "name": "Pingping Shen",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University"
            }
        ],
        "title": "Exploring a minimal two-component p53 model",
        "abstract": "The tumor suppressor p53 coordinates many attributes of cellular processes via interlocked feedback loops. To understand the biological implications of feedback loops in a p53 system, a two-component model which encompasses essential feedback loops was constructed and further explored. Diverse bifurcation properties, such as bistability and oscillation, emerge by manipulating the feedback strength. The p53-mediated MDM2 induction dictates the bifurcation patterns. We first identified irradiation dichotomy in p53 models and further proposed that bistability and oscillation can behave in a coordinated manner. Further sensitivity analysis revealed that p53 basal production and MDM2-mediated p53 degradation, which are central to cellular control, are most sensitive processes. Also, we identified that the much more significant variations in amplitude of p53 pulses observed in experiments can be derived from overall amplitude parameter sensitivity. The combined approach with bifurcation analysis, stochastic simulation and sampling-based sensitivity analysis not only gives crucial insights into the dynamics of the p53 system, but also creates a fertile ground for understanding the regulatory patterns of other biological networks. \u00a9 2010 IOP Publishing Ltd.",
        "keywords": [
            ""
        ],
        "venue": "Physical Biology",
        "year": 2010,
        "id": "JhgbdyRt"
    },
    "Idh8n8so": {
        "authors": [
            {
                "name": "Wen Chen",
                "org": "Department of Burn"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Burn"
            },
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Burn"
            },
            {
                "name": "Jian-Hua Zhan",
                "org": "Department of Burn"
            }
        ],
        "title": "Effect of bone marrow mesenchymal stem cells engraftment on secretion of inflammatory cytokine in the early stages of smoke inhalation injury in rabbits",
        "abstract": "Objective: To explore the effect of bone marrow mesenchymal stem cells (MSCs) engraftment on secretion of tumor necrosis factor-\u03b1 (TNF-\u03b1), interleukins (IL-1\u03b2, IL-6, IL-10) in peripheral blood and lung homogenates in the early stages of smoke inhalation injury. Methods: MSCs were proliferated by the method of whole marrow culture and identified by flow cytometry. Fifty-six healthy New Zealand rabbits were randomly divided into control group (C group, n=8), smoke inhalation injury group (S group, n=24) and smoke inhalation injury+MSCs engraftment group (M group, n=24). The latter two groups were subdivided into 2, 4, 6 hours after injury subgroups, with 8 rabbits in each group. The levels of TNF-\u03b1, IL-1\u03b2, IL-6 and IL-10 in peripheral blood and lung homogenates were measured by enzyme-linked immunosorbent assay (ELISA). Results: Compared with C group, concent of pro-inflammatory and anti-inflammatory cytokines in peripheral blood at each time point in S group were increased significantly. The concent of pro-inflammatory cytokines in lung homogenate at each time point in S group was significantly higher than those in C group, and that of anti-inflammatory cytokines showed no significant changes. Compared with the S group, concent of pro-inflammatory cytokines in peripheral blood in M group was decreased significantly, and that of anti-inflammatory cytokines was increased significantly (6 hours TNF-\u03b1 (\u03bcg/L); 1.7\u00b11.7 vs. 4.1\u00b11.6, IL-1\u03b2 (ng/L), 9.9\u00b11.7 vs. 21.2 \u00b1 2.6, IL-6 (\u03bcg/L); 1.0\u00b10.3 vs. 1.3\u00b10.2, IL-10 (ng/L); 15.2\u00b14.4 vs. 7.9\u00b13.5, all P<0.053. Concent of pro-inflammatory cytokines at each time point in M group was decreased significantly when compared with S group in lung homogenate, while only anti-inflammatory cytokine at 4 hours and 6 hours was increased significantly (6 hours TNF-\u03b1 (ng/L); 503.0\u00b1156.4 vs. 587.7\u00b1171-2, IL-1\u03b2 (ng/L); 0.4\u00b10.2 vs. 0.6\u00b10.2, IL-6 (ng/L), 155.2\u00b1 13.7 vs. 350.2\u00b120.3, IL-10 (ng/L), 23.3\u00b15.4 vs. 11.0\u00b15.6, all P<0.05). Conclusion: MSCs engraftment could decrease pro-inflammatory cytokines and increase anti-inflammatory cytokines in the early stages of smoke inhalation injury, thus ameliorates inflammatory response, which confers protective effect on smoke inhalation injury.",
        "keywords": [
            "Bone marrow mesenchymal stem cell",
            "Engraftment",
            "Immunomodulation",
            "Inflammatory cytokine",
            "Lung injury"
        ],
        "venue": "Chinese Critical Care Medicine",
        "year": 2011,
        "id": "Idh8n8so"
    },
    "dlEMxWTF": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Shu Yuan",
                "org": ""
            },
            {
                "name": "Shao-Dong Wang",
                "org": ""
            },
            {
                "name": "De-Hui Xi",
                "org": ""
            },
            {
                "name": "Hong-Hui Lin",
                "org": ""
            }
        ],
        "title": "The higher expression levels of dehydroascorbate reductase and glutathione reductase in salicylic acid-deficient plants may contribute to their alleviated symptom infected with RNA viruses",
        "abstract": "Salicylic acid (SA) is a critical signal for activation of both local and systemic resistance responses. However, SA-deficient plants adapt to RNA virus infections better, which show a lesssevere symptom and less reactive oxygen species (ROS) accumulation. The higher levels of reduced glutathione (GSH) and reduced ascorbic acid (AsA) in SA-deficient plants may contribute to their alleviated symptoms, which are consistent with their higher expression levels of dehydroascorbate reductase gene (DHAR) and glutathione reductase gene (GR). High-dose AsA or GSH treatment could alleviate the symptom and inhibit virus replication after 20 days, but ROS eliminators could not imitate the effect of AsA or GSH. The data show a new link between SA and AsA/GSH-mediated redox homeostasis. \u00a9 2011 Landes Bioscience.",
        "keywords": [
            "Ascorbic acid",
            "Glutathione",
            "Reactive oxygen species",
            "Salicylic acid",
            "Symptom alleviation"
        ],
        "venue": "Plant Signaling and Behavior",
        "year": 2011,
        "id": "dlEMxWTF"
    },
    "rZczgd3q": {
        "authors": [
            {
                "name": "Shou-Feng Wang",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Zhao-Long Ma",
                "org": ""
            },
            {
                "name": "Cai-Wei Xia",
                "org": ""
            }
        ],
        "title": "Assessment of the residual spine growth potential in idiopathic scoliosis by Risser sign and histological grading",
        "abstract": "Objective: To investigate the correlation between histological grade (HG) of vertebral growth plates and Risser grade in the female idiopathic scoliosis (IS) patients; and to identify whether Risser grading is a reliable indicator for accurate evaluation of the spinal residual growth potential. Methods: Thirty-nine samples of vertebral growth plates obtained during operation from 15 females IS patients, all female, aged 15.1 (12.4 - 18.0), underwent HE staining and light microscopy to determine the values of HG. X-ray photography of pelvis was conducted before operation to identify the Risser sign. The correlation of Risser grade with pubertal status was analyzed. Results: All the vertebral growth plates of the IS patients with the Risser grade of 0 showed growth activity. The vertebral growth plates showed HG II activity in 6 of the 16 IS patients with the Risser grade of 4. All the vertebral growth plates showed no growth activity in the 3 IS patients with the Risser grade of 5. There was a negative correlation between the HG and Risser grade in all 39 patients (r = -0.645, P = 0.000). The HG of the patients with the Risser grade of 4 was negatively correlated with the menarchal status (time between menarche and operation) (r = -0.710, P = 0.002). The residual growth potential of spinal growth plates of the patients with the Risser grades of 2 - 5 was significantly lower than of the patients with the Risser grades of 0 - 1 (P = 0.020). Conclusion: Risser sign may be a reliable indicator for predicting the spinal residual growth potential in IS patients, but it should be correlated with menarchal status and chronological ages.",
        "keywords": [
            "Histology, comparative",
            "Risser sign",
            "Scoliosis"
        ],
        "venue": "National Medical Journal of China",
        "year": 2008,
        "id": "rZczgd3q"
    },
    "qzcUDLr3": {
        "authors": [
            {
                "name": "Xin-Cheng Liao",
                "org": "Department of Burns"
            },
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Burns"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Burns"
            },
            {
                "name": "Zhong-Hua Fu",
                "org": "Department of Burns"
            },
            {
                "name": "Nian-Yun Wang",
                "org": "Department of Burns"
            },
            {
                "name": "Ming-Zhuo Liu",
                "org": "Department of Burns"
            },
            {
                "name": "Jie Luo",
                "org": "Department of Burns"
            }
        ],
        "title": "Effects of high frequency oscillatory ventilation combined with incremental positive end-expiratory pressure on respiratory and circulatory functions of dogs with inhalation injury",
        "abstract": "Objective: To study the effects of high frequency oscillatory ventilation (HFOV) combined with incremental positive end-expiratory pressure (IP) on respiratory and circulatory functions, and lung histopathology of dogs with smoke inhalation injury. Methods: After being treated with conventional mechanical ventilation, 12 dogs were inflicted with severe smoke inhalation injury and divided into group HFOV and group HFOV + IP according to the random number table, with 6 dogs in each group. Then they received corresponding ventilation for 8 hours respectively. Blood gas analysis results (pH value, PaO",
        "keywords": [
            "Blood gas analysis",
            "Burns, inhalation",
            "Hemodynamics",
            "High-frequency ventilation",
            "Positive-pressure respiration"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2013,
        "id": "qzcUDLr3"
    },
    "TG6T4nja": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": ""
            },
            {
                "name": "Xu-Sheng Qiu",
                "org": ""
            },
            {
                "name": "Wei-Wei Ma",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Yang Yu",
                "org": ""
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": ""
            },
            {
                "name": "Bang-Ping Qian",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Xu Sun",
                "org": ""
            },
            {
                "name": "Bobby K. W. Ng",
                "org": ""
            },
            {
                "name": "Jack C. Y. Cheng",
                "org": ""
            }
        ],
        "title": "How well does radiological measurements correlate with cosmetic indices in adolescent idiopathic scoliosis with lenke 5, 6 curve types?",
        "abstract": "Study Design: An association study between radiologic measurements and cosmetic appearance in adolescent idiopathic scoliosis (AIS) patients with Lenke 5 and 6 curve types. Objective: The present study aimed at investigating the correlation between radiologic measurements and clinical cosmetic assessment indices in AIS with Lenke 5 and 6 curve types. Summary of background data: Cosmetic truncal and pelvic distortions are of important concern to patients with AIS. In the clinical assessment of AIS, over reliance on radiologic evaluations without corresponding objective assessment of the external physical appearance is commonly practiced. Patients having the same radiologic findings could be quite different in their physical appearance and the reverse could also happen. These observations imply that discrepancies could well exist in the cosmetic versus radiologic evaluation in AIS. Methods: A total of 52 AIS patients with dominant lumbar/thoracolumbar curve including 36 Lenke type 5 and 16 Lenke type 6 were recruited. Cobb angles, coronal balance, thoracic containment, apical vertebral translation (AVT), pelvic oblique, apical vertebral rotation were measured in the standard long-standing posteroanterior radiographs. Waistline Height Index, Waistline Depth Index, Waistline Area Index, Waist Area Index, and hump index (\u03b1) were measured clinically and the 5 parameters combined into a composite cosmetic Index (CCI). Pearson rank correlation coefficient was used to assess measurement reliability for the cosmetic indices; correlation analysis and multiple linear regression analysis were made between the radiologic measurements and CCI. Results: The correlation coefficients between radiologic measurements and CCI ranged from -0.29 to 0.57, among which AVT was found to have the highest correlation coefficient, but not the Cobb angle. AVT, Cobb angle, coronal balance, thoracic containment were found to be significantly correlated with CCI (P < 0.05) with all correlation coefficients below 0.6. From linear regression analysis, CCI could be predicted by the equation (CCI = 98.0-1.18 \u00d7 AVT-0.29 \u00d7 Cobb angle) with adjusted R of 0.33 (implying that 33% of CCI variation could be accounted for by Cobb angle and AVT). Conclusion: The present study showed that a number of radiologic indices could only partially reflect the objective cosmetic appearances in Lenke type 5 and 6 curves in AIS. Spine surgeons should put more emphasis in the clinical cosmetic evaluations and not relying solely on the radiologic assessment in AIS. \u00a9 2010, Lippincott Williams & Wilkins.",
        "keywords": [
            "cosmesis",
            "idiopathic scoliosis",
            "radiology"
        ],
        "venue": "Spine",
        "year": 2010,
        "id": "TG6T4nja"
    },
    "DyoCN4Zq": {
        "authors": [
            {
                "name": "Guanghua Guo",
                "org": "Department of Burns"
            },
            {
                "name": "Xiangjun Bai",
                "org": "Department of Traumatic Surgery"
            },
            {
                "name": "Chen Cai",
                "org": "Department of Burns"
            },
            {
                "name": "Jun Zhang",
                "org": "Department of Physiology"
            },
            {
                "name": "Xin Li",
                "org": "Department of Physiology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Traumatic Surgery"
            },
            {
                "name": "Shangdong Liang",
                "org": "Department of Physiology"
            }
        ],
        "title": "The protective effect of different enteral nutrition combined with growth hormone on intestinal mucosal damage of scalded rats",
        "abstract": "Objective: To investigate the protective effect of standard enteral nutrition (EN) and enteral immunonutrition (EIN) combined with recombinant human growth hormone rhGH on intestinal mucosa damage in scalded rats. Methods: Rats subjected to 30% total body surface area (TBSA III\u00b0), and they were divided randomly into five groups referred to as EN, EIN, EN + rhGH, EIN + rhGH and control groups. After injury on days 1, 4, 7 and 10, venous blood and intestinal mucus were collected to monitor the level of serum endotoxin, tumor necrosis factor-\u03b1 (TNF-\u03b1) and the concentration of intestinal mucus s-IgA. The number of IgA plasma cells in intestinal tissue and proliferating cell nuclear antigen (PCNA) in intestinal mucosa were detected using the method of immunohistochemistry. Results: After injury on days 4, 7 and 10, PCNA value of the intestinal mucosa, the number of IgA plasma cells in intestinal lamina and the concentration of intestinal mucus s-IgA in EIN and EN + rhGH groups are significantly increased compared with those in EN group (P < 0.05 or P < 0.01), but serum endotoxin and TNF-\u03b1 levels are reduced than those in EN group. After injury on days 4, 7 and 10, PCNA values, propria IgA plasma cell number and s-IgA concentration in EIN + rhGH group have no significant difference compared with those in EIN group (P > 0.05), while the serum endotoxin and TNF-\u03b1 levels are lower than those in EIN group. Conclusions: EN or EIN combined with rhGH has the additional effect on treatment to reduce intestinal mucosa damage of scalded rats and strengthen the protection of intestinal mucosa damage. Copyright \u00a9 2010 Published by Elsevier Ltd and ISBI. All rights reserved.",
        "keywords": [
            "Burn",
            "Enteral immune nutrition",
            "Enteral nutrition",
            "Growth hormone",
            "Recombinant human"
        ],
        "venue": "Burns",
        "year": 2010,
        "id": "DyoCN4Zq"
    },
    "hfZCgYV2": {
        "authors": [
            {
                "name": "Ying-Ying Lu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Da-Dao Jing",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Xie-Ning Wu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Lun-Gen Lu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Gen-Quan Zhou",
                "org": "Department of Radiology"
            },
            {
                "name": "Xing-Peng Wang",
                "org": "Department of Gastroenterology"
            }
        ],
        "title": "Multiple endocrine neoplasia type 1 with upper gastrointestinal hemorrhage and perforation: A case report and review",
        "abstract": "Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary syndrome known to predispose subjects to endocrine neoplasms in a variety of tissues such as the parathyroid glands, pituitary gland, pancreas and gastrointestinal tract. We herein report a patient with a past history of pituitary adenoma, presenting with symptoms of chronic diarrhea for nearly one year and a sudden upper gastrointestinal hemorrhage as well as perforation without signs. Nodules in the duodenum and in the uncinate process and tail of pancreas and enlargement of the parathyroid glands were detected on preoperative imaging. Gastroscopy revealed significant ulceration and esophageal reflux diseases. The patient underwent subtotal parathyroidectomy and autotransplantation, pylorus-preserving pancreaticoduodenectomy and pancreatic tail resection and recovered well. The results observed in our patient suggest that perforation and bleeding of intestine might be symptoms of Zollinger- Ellison Syndrome in patients with MEN1. \u00a9 2013 Baishideng. All rights reserved.",
        "keywords": [
            "Gastrinoma",
            "Gastrointestinal hemorrhage",
            "Hyperparathyroidism",
            "Perforation",
            "Pituitary adenoma"
        ],
        "venue": "World Journal of Gastroenterology",
        "year": 2013,
        "id": "hfZCgYV2"
    },
    "ZDqH0eK8": {
        "authors": [
            {
                "name": "Feng Peng",
                "org": ""
            },
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Rui Tian",
                "org": ""
            },
            {
                "name": "Cheng-Jian Shi",
                "org": ""
            },
            {
                "name": "Meng Xu",
                "org": ""
            },
            {
                "name": "Xin Wang",
                "org": ""
            },
            {
                "name": "Ming Shen",
                "org": ""
            },
            {
                "name": "Jun Hu",
                "org": ""
            },
            {
                "name": "Shu-You Peng",
                "org": ""
            },
            {
                "name": "Ren-Yi Qin",
                "org": ""
            }
        ],
        "title": "\"total arterial devascularization first\" technique for resection of pancreatic head cancer during pancreaticoduodenectomy",
        "abstract": "Summary: Integrated resection of the pancreatic head is the most difficult step in radical pancreaticoduodenectomy (RPD) in patients with the portal vein (PV) and superior mesenteric vein (SMV) invasion or oppression by the tumor. This study introduced a new idea and skill named the \"total arterial devascularization first\" (TADF) technique and its applications in RPD. Three arterial blood supplies of pancreatic head were obstructed before dissection of veins. The critical steps included exposure of the anterior surface of the abdominal aorta (AA) by completely transecting neural and connective tissue between superior mesenteric artery (SMA) and pancreatic mesounsinate, and transection of the mesounsinate from the origin of SMA to the root of the celiac trunk. From January 2012 through May 2013, a total of 58 patients with PV/SMV invasion or oppression underwent RPD using this technique. The median operative time was 5.1 h (ranging 4.5-8.1 h). The median intraoperative blood loss was 450 mL (ranging 200-900 mL). No intraoperative and postoperative bleeding of pancreatic head region occurred. Among the 58 patients, 21 were subjected to vessel lateral wall angiectomy or angiorrhaphy, and 10 to angiectomy and end-to-end anastomosis. The incidence of postoperative bleeding, postoperative pancreatic fistula and biliary fistula was 5.2%, 6.8%, and 1.7%, respectively. No patients died 3 months after operation. The TADF technique is a new method for intricate RPD and could improve the security of surgery and reduce intraoperative bleeding, which is expected to become standardized surgical approach for RPD. \u00a9 2013 Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "pancreatic head tumor",
            "pancreaticoduodenectomy"
        ],
        "venue": "Journal of Huazhong University of Science and Technology - Medical Science",
        "year": 2013,
        "id": "ZDqH0eK8"
    },
    "FJbyQEP6": {
        "authors": [
            {
                "name": "Hui Chen",
                "org": "Nanjing BenQ Hospital"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Leilei Chen",
                "org": "Central Laboratory"
            },
            {
                "name": "Lei Li",
                "org": "Central Laboratory"
            },
            {
                "name": "Junhao Chen",
                "org": "Central Laboratory"
            },
            {
                "name": "Chaoying Zhang",
                "org": "Department of Biology"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery Department"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery Department"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery Department"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery Department"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery Department"
            },
            {
                "name": "Weiwei Ma",
                "org": "Spine Surgery Department"
            }
        ],
        "title": "The expression of neurofibromin in human osteoblasts and chondrocytes",
        "abstract": "The goal of this study was to determine if neurofibromin is expressed in cultured human osteoblasts and chondrocytes that were isolated from ilia and ilial growth plate. Purity of the osteoblast and chondrocyte cultures was confirmed by alkaline phosphatase and toluidine blue staining, respectively. The reverse transcription-polymerase chain reaction (RT-PCR) was performed to detect neurofibromin mRNA. Indirect immunofluorescence and Western blot studies were done to delineate the cellular distribution and expression levels of neurofibromin. These experiments show that neurofibromin is expressed at low levels in human osteoblasts and chondrocytes and is located mainly in the cytoplasm. Only the type II isoform of neurofibromin is detected in these cells. These findings suggest that the type II isoform of neurofibromin plays a physiological role in human osteoblasts and chondrocytes. Whether functional deficiency of neurofibromin is responsible for skeletal abnormalities remains to be established. \u00a9 2008 by the Association of Clinical Scientists, Inc.",
        "keywords": [
            "Chondrocyte",
            "Neurofibromatosis-1",
            "Neurofibromin",
            "Osteoblast",
            "Von Recklinghausen disease"
        ],
        "venue": "Annals of Clinical and Laboratory Science",
        "year": 2008,
        "id": "FJbyQEP6"
    },
    "EQQ4DqkL": {
        "authors": [
            {
                "name": "Hongda Bao",
                "org": "Spine Surgery"
            },
            {
                "name": "Peng Yan",
                "org": "Spine Surgery"
            },
            {
                "name": "Weiguo Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Mike Bao",
                "org": "Geisel School of Medicine"
            },
            {
                "name": "Yang Li",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhen Zhang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Validation and reliability analysis of the Spinal Deformity Study Group classification for L5-S1 lumbar spondylolisthesis",
        "abstract": "Study Design. An intra- and interobserver reliability study. Objective. To assess the intra- and interobserver reliability of the Spinal Deformity Study Group (SDSG) system for classifying adolescent and adult L5-S1 spondylolisthesis. Summary of Background Data. Reliability of the SDSG classification has only been previously validated in adolescent patients as performed by the SDSG study group investigators. Methods. A total of 80 patients with L5-S1 spondylolisthesis were included in this study. Only dysplastic and isthmic spondylolisthesis were included in this study. Long-cassette standing lateral radiographs of the spine and pelvis were obtained. All 80 cases were classified according to the SDSG classification by four observers. After a 2-week interval, the same classification was independently repeated by each observer with the cases in a different randomly assigned order. The Fleiss' \u03ba coefficient was calculated to test the intra- and interobserver reliabilities of the SDSG classification. Results. The present study included all six types of SDSG classification. Overall intra- and interobserver agreements were 86.6% (\u03ba: 0.830) and 73.3% (\u03ba: 0.648), respectively. The intraand interobserver agreements and repeatability associated with slip grade were 89.7% (\u03ba: 0.824) and 87.7% (\u03ba: 0.721), respectively. Regarding sacropelvic and spinal balance, intraand interobserver agreements and repeatability were 83.7% (\u03ba: 0.735) and 77.5% (\u03ba: 0.602) for low-grade slips, and 90.75% (\u03ba: 0.883) and 90.4% (\u03ba: 0.851) for high-grade slips, respectively. Conclusion. Substantial intra- and interobserver reliability was found for the SDSG classification in L5-S1 lumbar spondylolisthesis. SDSG classification system is a simple and clear classification scheme incorporating spinopelvic parameters, which provides significant clinical utility.",
        "keywords": [
            "Adult",
            "Classification",
            "Reliability",
            "Sagittal alignment",
            "Spondylolisthesis"
        ],
        "venue": "Spine",
        "year": 2015,
        "id": "EQQ4DqkL"
    },
    "c747cm7j": {
        "authors": [
            {
                "name": "Dong Chen",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Rui Tian",
                "org": ""
            },
            {
                "name": "Wen-Liang Lu",
                "org": ""
            },
            {
                "name": "Ren-Yi Qin",
                "org": ""
            }
        ],
        "title": "Pancreatoduodenectomy for tumors of the neck of the pancreas",
        "abstract": "AIM: To summarize the clinical features of tumors of the neck of the pancreas and investigate the application of selective arteriovenous priority processing and total pancreatic blood occlusion in pancreatoduodenectomy for tumors of the neck of the pancreas. METHODS: Clinical and pathological data for 25 patients with tumors of the neck of the pancreas who underwent pancreatoduodenectomy at our hospital from January 2011 to June 2013 were retrospectively analyzed. Selective arteriovenous priority processing and total pancreatic blood occlusion were performed depending on the patient' s features. RESULTS: This group of patients had no jaundice but suffered from back pain, and 21 of them had severe back pain. During the operation, hard pancreatic texture, dilatation of the pancreatic duct, and various degree of inflammation were visible. All the tumors invaded either arteries or veins. No morbidity was observed. The operative time was 7-8 h, and the blood loss was 600-900 mL. Among all the postoperative mortalities, there were 2 cases of gastrointestinal bleeding, 4 cases of delayed gastric emptying and 3 cases of diarrhea after, and all were treated by conservative management without reoperation. The symptoms of back pain was totally relieved in 10 cases, substantially relived in 13 and partially relieved in 2. CONCLUSION: Tumors of the neck of the pancreas have no specific symptoms in early stages. The symptom of jaundice appears late. In the late stages of the disease, back pain occurs in all cases, with the dilation of the distal pancreatic duct, a hard texture of the pancreas and severe inflammation. The tumor boundary is not clear, and there is a tendency to involve adjacent vessels. Selective arteriovenous priority processing and total pancreatic blood occlusion can guarantee the safety of the operation and reduce the incidence of postoperative complications. \u00a9 2014 Baishideng Publishing Group Co., Limited. All rights reserved.",
        "keywords": [
            "Pancreatoduodenectomy",
            "Tumor of the neck of the pancreas"
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2014,
        "id": "c747cm7j"
    },
    "nojeVDFI": {
        "authors": [
            {
                "name": "Hongda Bao",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            },
            {
                "name": "Fei Wang",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            },
            {
                "name": "Mark Bentley",
                "org": "Orthopaedics Surgery, Sir Charles Gairdner Hospital"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Town Hospital of Nanjing University Medical School"
            }
        ],
        "title": "Is the sacro-femoral-pubic angle predictive for pelvic tilt in adolescent idiopathic scoliosis patients?",
        "abstract": "Study Design: This was a retrospective radiographic study. Objective: The aim of this study was to evaluate the correlation between pelvic tilt (PT) and the sacro-femoral-pubic angle (SFP angle) in AIS patients and to clarify whether the predictability of PT is affected by different curve patterns. Summary of Background Data: Pelvic retroversion is one of the compensatory mechanisms to maintain upright position and is also tied to health-related quality of life in patients with adolescent idiopathic scoliosis (AIS). However, measurement of spino-pelvic parameters including PT may not be accurate because of difficulty in visualizing femoral heads on lateral radiographs in some patients. MATERIALS AND Methods: In this study, 101 female AIS patients were recruited. The subjects were divided into 2 groups: thoracic scoliosis (TS) and lumbar scoliosis (LS) group. Long-cassette standing upright radiographs were obtained; PT and SFP angles were measured through digital analysis software (Surgimap Spine Software, New York, NY). The relations between PT and SFP angle were determined by the Pearson correlation coefficient (r). Linear regressions between PT and SFP angle were also performed. Results: The SFP angle was strongly correlated with PT in both groups, and PT could be estimated by the formulas: PT=74.052-0. 991\u00d7SFP angle in the TS group and PT=65.345-0.881\u00d7SFP angle in the LS group. In the TS group, the SFP angle correlated with PT strongly with a Pearson coefficient of 0.65. Whereas in the LS group, the coefficient was weaker than that in the TS group (0.48 vs. 0.65); however, it still showed that PT was significantly associated with SFP. Conclusions: Given the high correlation between PT and SFP angle, the SFP angle should be considered a reliable alternative option to PT, which has routinely excellent visibility in coronal films in AIS patients. The predictability was more accurate for AIS patients with thoracic curves than with lumbar curves. \u00a9 2014 by Lippincott Williams & Wilkins.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "pelvic tilt",
            "sacro-femoral-pubic angle",
            "sagittal alignment"
        ],
        "venue": "Journal of Spinal Disorders and Techniques",
        "year": 2014,
        "id": "nojeVDFI"
    },
    "e8jIdXa2": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Zhen-Zhen Hu",
                "org": "Department of Pathophysiology"
            },
            {
                "name": "Guang-Hua Guo",
                "org": "Burn Institute"
            }
        ],
        "title": "Ex-pulmonary adult stem cell engraftment in treatment of acute lung injury: Recent progress",
        "abstract": "Engraftment with ex-pulmonary adult stem cells has great potential for treatment of acute lung injury (ALI). The engrafted adult ex-pulmonary stem cells can migrate to the injured lung tissue guided by a series of signal factors released by injured pulmonary tissue cells. Stem cells localized in the injured lung tissue and inflammatory area can differentiate into lung tissue cells (including lung epithelial cells and pulmonary vascular endothelial cells) and exert their functions. The engrafted expulmonary adult stem cells are not only capable of differentiation, but also have anti-inflammatory effect and immunomodulatory effect, making the related area a focus of study.",
        "keywords": [
            "Acute lung injuries",
            "Adult stem cell",
            "Biological effect",
            "Stem cell transplantation"
        ],
        "venue": "Academic Journal of Second Military Medical University",
        "year": 2009,
        "id": "e8jIdXa2"
    },
    "d3T2vmfJ": {
        "authors": [
            {
                "name": "Hongli Sun",
                "org": "Biointerfaces Institute"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Qingang Hu",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Paul H. Krebsbach",
                "org": "Biointerfaces Institute"
            }
        ],
        "title": "Controlling stem cell-mediated bone regeneration through tailored mechanical properties of collagen scaffolds",
        "abstract": "Mechanical properties of the extracellular matrix (ECM) play an essential role in cell fate determination. To study the role of mechanical properties of ECM in stem cell-mediated bone regeneration, we used a 3D invivo ossicle model that recapitulates endochondral bone formation. Three-dimensional gelatin scaffolds with distinct stiffness were developed using 1-Ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDC) mediated zero-length crosslinking. The mechanical strength of the scaffolds was significantly increased by EDC treatment, while the microstructure of the scaffold was preserved. Cell behavior on the scaffolds with different mechanical properties was evaluated invitro and invivo. EDC-treated scaffolds promoted early chondrogenic differentiation, while it promoted both chondrogenic and osteogenic differentiation at later time points. Both micro-computed tomography and histologic data demonstrated that EDC-treatment significantly increased trabecular bone formation by transplanted cells transduced with AdBMP. Moreover, significantly increased chondrogenesis was observed in the EDC-treated scaffolds. Based on both invitro and invivo data, we conclude that the high mechanical strength of 3D scaffolds promoted stem cell mediated bone regeneration by promoting endochondral ossification. These data suggest a new method for harnessing stem cells for bone regeneration invivo by tailoring the mechanical properties of 3D scaffolds. \u00a9 2013 Elsevier Ltd.",
        "keywords": [
            "BMP2",
            "Bone regeneration",
            "Endochondral ossification",
            "Mesenchymal stem cells",
            "Scaffold stiffness"
        ],
        "venue": "Biomaterials",
        "year": 2014,
        "id": "d3T2vmfJ"
    },
    "eAzC2Fpr": {
        "authors": [
            {
                "name": "Jun Qiao",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Tao Wu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Leiei Xu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Indication for preoperative MRI of neural axis abnormalities in patients with presumed thoracolumbar/lumbar idiopathic scoliosis",
        "abstract": "Purpose: The purpose of this study was to investigate the incidence of neural axis abnormalities in patients with presumed \"idiopathic\" thoracolumbar or lumbar scoliosis by magnetic resonance imaging (MRI) and try to determine which clinical and radiographic characteristics correlate with neural axis abnormalities on MRI in these patients. Methods: The database of a single spinal deformity center was retrospectively reviewed to identify all patients with a primary diagnosis of idiopathic scoliosis (IS) between January 2003 and August 2011. A total of 446 patients with main thoracolumbar or lumbar curves were identified. Radiographic parameters including main curve Cobb angles, location of curve apex, span of main curve, thoracic kyphosis (T5-T12), thoracolumbar junction kyphosis (T10-L2), lumbar lordosis (L1-S1), and sagittal and coronal balance were measured. Results: Neural axis abnormalities were detected in 35 (7.8 %) patients. For patients with neural axis abnormalities, a higher proportion of male gender and long thoracolumbar curves were presented. In these patients, the mean age was smaller and the mean Cobb angle of main curve was larger. Greater thoracic kyphosis (\u226530) was more frequently found in those with neural axis abnormalities. The incidences of thoracolumbar junction hyperkyphosis were similar between two groups (P > 0.05). There was no difference between two groups as to lumbar lordosis and coronal and sagittal balance. Conclusion: We recommend the routine use of MRI in the patients with one or more of the following characteristics: right curves, long curve span, apex at thoracolumbar spine and hyperthoracic kyphosis. \u00a9 2012 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "MRI",
            "Neural axis abnormalities",
            "Thoracolumbar/lumbar idiopathic scoliosis"
        ],
        "venue": "European Spine Journal",
        "year": 2013,
        "id": "eAzC2Fpr"
    },
    "QFrxECsy": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Comparison of the curative effects of video assisted thoracoscopic anterior correction and small incision, thoracotomic anterior correction for idiopathic thoracic scoliosis",
        "abstract": "Background: The advantages of video assisted thoracoscopic anterior correction for scoliosis are minimal invasion and relatively short-time instrumentation; however the relatively steep learning curve cannot be ignored. Small incision, thoracotomic anterior correction for idiopathic thoracic scoliosis could be another choice because of less demanding technique. We compared the outcomes of these two techniques. Methods: Forty-nine patients with idiopathic right thoracic scoliesis were randomly divided into two groups. Group A was 12 girls with mean age 14.9 years, mean Cobb angle 52\u00b0 and Risser signs \"+++\" to \"++++\". Ten patients received video assisted thoracoscopic anterior correction with Eclipse rectification and two with Frontier instrumentation. Group B was 4 boys and 33 girls with mean age 14.1 years, mean Cobb angle of 56\u00b0 and Risser signs \"++\" to \"++++\". These patients underwent small incision, thoracotomic anterior instrumentation. The operation time, blood loss, postoperative drainage, instrumented levels, curve correction and early loss of correction of both groups were analyzed. Results: Group A had average operation time of (390\u00b182) minutes, intraoperative blood loss of (600\u00b1155) ml, instrumented level of 7.4\u00b11.3, postoperative drainage of (500\u00b1160) ml, correction rate of (65\u00b116)% and loss of correction during the 18-36 month followup of (8.6\u00b12.9)%. Group B had average operative time of (220\u00b180) minutes, intraoperative blood loss of (320\u00b1120) ml, instrumented level of 7.8\u00b10.9, postoperative drainage of (210\u00b190) ml, curve correction rate of (70\u00b112)% and loss of correction during the 18-36-month followup of (4.6\u00b13.9)%. The curve correction rates of the two groups were not statistically significant (P >0.05). However, the operative time, blood loss, postoperative drainage, and early loss of correction showed statistical significance (P <0.05). Conclusion: Both video assisted thoracoscopic anterior correction and small incision thoracatomic anterior correction are sale and effective in correcting the idiopathic thoracic scoliosis.",
        "keywords": [
            "Correction",
            "Minimal invasion",
            "Scoliosis",
            "Thoracoscopy"
        ],
        "venue": "Chinese Medical Journal",
        "year": 2008,
        "id": "QFrxECsy"
    },
    "v3X7aeMx": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Radiological presentations in relation to curve severity in scoliosis associated with syringomyelia",
        "abstract": "BACKGROUND: Few radiographic guidelines are available to assist clinicians in deciding when to order magnetic resonance imaging in patients with a normal history and physical examination. Most of the recent reports on the radiographic characteristics of scoliosis are limited by a small number of patients and a shortage of large curves. The association between radiological features and the severity of scoliosis has little been elaborated. The purpose of this study is to further explore the radiological presentations in relation to curve severity in scoliosis associated with Chiari malformation and syringomyelia. METHODS: A total of 87 children and adolescents were divided into 3 groups: group 1 (10 degrees \u2264 Cobb angle \u2264 30 degrees), group 2 (30 degrees < Cobb angle \u2264 60 degrees), and group 3 (Cobb angle > 60 degrees). Curves were classified into typical and atypical patterns in the coronal plane, and the sagittal profile was measured. Cerebellar tonsillar descent or syrinx patterns in relation to curve severity and the frequency of atypical curves were also investigated. RESULTS: The frequency of atypical curve patterns from groups 1 to 3 was 46.2%, 45.2%, and 40.7%, respectively. A total of 65.3% of patients with typical curve patterns had atypical features in all of the 3 groups. There was a significant difference of kyphotic angle among the 3 groups showing that the larger curves tended to have greater thoracic kyphosis. Both the degree of cerebellar tonsillar descent and syrinx patterns had no correlation with the curve severity or the frequency of atypical curves. CONCLUSIONS: These results show that radiographic presentations including atypical curve patterns, atypical features in typical curve patterns, and a normal to hyperkyphotic thoracic spine may suggest the need for a preoperative magnetic resonance imaging. Kyphosis may be indicative of progressive scoliosis. There is no evidence to suggest that the degree of cerebellar tonsillar descent and syrinx patterns have an effect on the progress of scoliosis and the frequency of atypical curves. LEVEL OF EVIDENCE: Systematic review 2 of Level III studies. \u00a9 2008 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Chiari malformation",
            "Pattern",
            "Scoliosis",
            "Severity",
            "Syringomyelia"
        ],
        "venue": "Journal of Pediatric Orthopaedics",
        "year": 2008,
        "id": "v3X7aeMx"
    },
    "Jbykb7ej": {
        "authors": [
            {
                "name": "Cheng Nie",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Ke-Jian Qian",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Lian-Qun Wang",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Fen Liu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Zhen-Guo Zeng",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Feng Zhu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Liang Xia",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Yi-An Zhan",
                "org": "Intensive Care Unit"
            }
        ],
        "title": "A clinical study on organ protective effect of early high-volume hemofiltration (HVHF) in patients with multiple organ dysfunction syndrome (MODS) complicated by acute kidney injury (AKI)",
        "abstract": "Objective: To investigate the organ protective effect of early continuous HVHF in patients with MODS complicated by AKI. Methods: 117 patients requested HVHF in ICU due to MODS/AKI were enrolled from June 2006 to June 2011 for clinical data collection. The patients were categorized, by RIFLE scale (R-risk of renal dysfunction, I-injury to the kidney, F-failure of kidney, L-loss of kidney function, E-end stage kidney disease), into three groups: RIFLE-R (n=15), RIFLE-I (n=23) and RIFLE-F (n=79). The values of their serum creatinine (SCr), oxygenation index (PaO ",
        "keywords": [
            "Acute kidney injury",
            "High-volume hemofiltration",
            "Multiple organ dysfunction syndrome",
            "Organ protection"
        ],
        "venue": "Chinese Critical Care Medicine",
        "year": 2011,
        "id": "Jbykb7ej"
    },
    "6jSG6pYy": {
        "authors": [
            {
                "name": "Xing-Guang Deng",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "Feng Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "Ying-Juan Chen",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "Jian Liu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "Tong Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "Jing-Yi Li",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "De-Hui Xi",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            },
            {
                "name": "Hong-Hui Lin",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            }
        ],
        "title": "A more sensitive and rapid multiplex RT-PCR assay combining with magnetic nanobeads for simultaneous detection of viruses in sweet potato",
        "abstract": "An improved multiplex RT-PCR assay combined with magnetic nanobeads (MNB-RT-PCR) was developed for simultaneous detection of four sweet potato viruses, Sweet potato virus G (SPVG), Sweet potato feathery mottle virus (SPFMV), Sweet potato virus C (SPVC) and Sweet potato chlorotic fleck virus (SPCFV). Four primer pairs specific for each virus were designed and the corresponding PCR products were 169, 357, 516 and 900 bp in length for SPVG, SPFMV, SPVC and SPCFV, respectively. The specificity of the method was tested using different combinations of virus templates, and the identities of the amplification products were confirmed by sequencing. The limits of detection for all four viruses by single and multiplex MNB-RT-PCR assays were comparable. The assay was further evaluated using laboratory and field samples compared with a conventional CTAB-RT-PCR assay, and the comparative results showed that the MNB-RT-PCR assay was more rapid and sensitive. These results suggest that the multiplex MNB-RT-PCR assay is an effective and preferable method for virus detection in sweet potato. \u00a9 2014 Koninklijke Nederlandse Planteziektenkundige Vereniging.",
        "keywords": [
            "Detection",
            "Magnetic nanobeads",
            "Multiplex RT-PCR",
            "Sweet potato virus"
        ],
        "venue": "European Journal of Plant Pathology",
        "year": 2014,
        "id": "6jSG6pYy"
    },
    "BSvdmam3": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Rong-Rong Nie",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Ling Wu",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Lei Liu",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Wei Tang",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Wei-Dong Tlan",
                "org": "State Key Laboratory of Oral Diseases"
            }
        ],
        "title": "Spontaneous odontogenic differentiation and critical gene expression of mouse dental papilla mesenchymal cell in vitro",
        "abstract": "Objective To observe the spontaneous odontogenic differentiation of mouse dental papilla mesenchymal cells in blood serum medium. And to detect the critical gene expression of correlated transcription factors what are specific to odontogenic and osteogenic differentiation. Methods The primary dental papilla mesenchymal cells what had been obtained from E16. 5 d murine embryo were serially subcultivated in the simple serum medium and the serum medium supplemented with LIF(leukocyte inhibitory factor) respectively. It was observed whether the dental papilla mesenchymal cells differentiated into odontoblast phenotype or kept the undifferentiation phenotype. The mRNA expression of specific transcription factors were detected in cells with or without odontogenic differentiation. Results The fourth generation and behind of mouse dental papilla mesenchymal cells what were cultured in simple serum medium could spontaneously differentiate to odontoblast, while the undifferentiation phenotype of dental papilla mesenchymal cells could be lasting to ninth generation when they cultured in medium supplemented with 10",
        "keywords": [
            "Gene expression",
            "Leukocyte inhibitory factor",
            "Mouse dental papilla mesenchymal cells",
            "Odontogenic differentiation"
        ],
        "venue": "Journal of Sichuan University (Medical Science Edition)",
        "year": 2008,
        "id": "BSvdmam3"
    },
    "pB640XH8": {
        "authors": [
            {
                "name": "Shoufeng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhaolong Ma",
                "org": "Spine Surgery"
            },
            {
                "name": "Caiwei Xia",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Histomorphological study of the spinal growth plates from the convex side and the concave side in adolescent idiopathic scoliosis",
        "abstract": "Asymmetrical growth of the vertebrae has been implicated as one possible etiologic factor in the pathogenesis of adolescent idiopathic scoliosis. The longitudinal vertebral growth derives from the endochondral ossification of the vertebral growth plate. In the present study, the growth plates from the convex and concave side of the vertebrae were characterized by the method of histology and immunohistochemistry to evaluate the growth activity, cell proliferation, and apoptosis. Normal zoned architectures were observed in the convex side of the growth plate and disorganized architectures in the concave side. The histological grades were significantly different between the convex and the concave side of the growth plate in the apex vertebrae (P < 0.05). The histological difference was also found significant statistically between end vertebrae and apex vertebrae in the concave side of vertebral growth plates (P < 0.05). The proliferative potential indexes and apoptosis indexes of chondrocytes in the proliferative and hypertrophic zone in the convex side were significantly higher than that in the concave side in the apex vertebral growth plate (P < 0.05). There was a significant difference of the proliferative potential index (proliferating cell nuclear antigen, PCNA index) between convex side and concave side at the upper end vertebra (P < 0.05). The difference of the proliferative potential index and apoptosis index were found significant statistically in the concave side of the vertebral growth plate between end vertebrae and apex vertebrae (P < 0.05). The same result was also found for the apoptosis index (terminal deoxynucleotidyl transferase mediated deoxyuridine triphosphate biotin nick end labeling assay, TUNEL index) in the convex side of vertebral growth plate between end vertebrae and apex vertebrae (P < 0.05). Some correlation were found between radiographic measurements and proliferation and apoptosis indexes. The difference in histological grades and cellular activity between the convex and concave side indicated that the bilateral growth plate of the vertebrae in AIS patients have different growth kinetics which may affect the curve progression. \u00a9 2007 Wang et al; licensee BioMed Central Ltd.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Orthopaedic Surgery and Research",
        "year": 2007,
        "id": "pB640XH8"
    },
    "ISEHrc3S": {
        "authors": [
            {
                "name": "Jun Jiang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Saihu Mao",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Qinghua Zhao",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Different proximal thoracic curve patterns have different relative positions of esophagus to spine in adolescent idiopathic scoliosis: A computed tomography study",
        "abstract": "Study Design.: A computed tomography (CT) study. Objective.: To evaluate the changed relative positions of esophagus in proximal thoracic (PT) curves of adolescent idiopathic scoliosis (AIS) patients and analyze the potential risks of esophageal injuries from thoracic pedicle screw (TPS) insertion. Summary of Background Data.: Translation and rotation of the vertebrae could lead to altered relative positions of surrounding vital structures in AIS patients. The changed positions of aorta and spinal cord in main thoracic (MT) curve have been comprehensively investigated; however, no studies have analyzed the relative position of esophagus in PT curve. Methods.: Twenty patients with complete proximal thoracic (CPT group) curve, 22 patients with fractional proximal thoracic (FPT group) curve, and 14 normal patients with a straight spine (normal group) were included. Axial CT images from T2 to T5 at the midvertebral body level were obtained to evaluate esophagus-vertebral angle (EVA, defined as 0\u00b0 when the esophagus was located directly lateral to the left, 90\u00b0 when strictly anterior, and 180\u00b0 when directly lateral to the right). The percentages of esophagus in the direction of screw passage were calculated to analyze potential risks of esophageal injuries during TPS insertion. Results.: EVA in the FPT group was significantly smaller than that in the normal group (P < 0.05), whereas EVA in the CPT group was significantly greater than that in the normal group (P < 0.05) at each level. The esophagus was located approximately anterior to the vertebral body in the normal group but shifted anterolaterally to the right in the CPT group and anterolaterally to the left in the FPT group. The esophagus was at a high risk of injury with right anterior penetrated TPS in the CPT group and was at a high risk of injury with left anterior penetrated TPS in the FPT group. Conclusion.: Different anatomic patterns of PT curves could cause different altered positions of esophagus relative to spine and result in different potential risks of esophageal injuries during TPS insertion. Spine surgeons should choose appropriate pedicle screw length to avoid anterior cortical perforation in the PT region of AIS patients. \u00a9 2012, Lippincott Williams & Wilkins.",
        "keywords": [
            "computed tomography",
            "esophagus",
            "pedicle screw",
            "proximal thoracic curve",
            "scoliosis"
        ],
        "venue": "Spine",
        "year": 2012,
        "id": "ISEHrc3S"
    },
    "358RWEpR": {
        "authors": [
            {
                "name": "Ling Wu",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Yao Wu",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Yunfeng Lin",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Xin Nie",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Wei Jing",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Ju Qiao",
                "org": "Department of Orthodontics"
            },
            {
                "name": "Lei Liu",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Wei Tang",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Xiaohui Zheng",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Weidong Tian",
                "org": "Department of Oral and Maxillofacial Surgery"
            }
        ],
        "title": "Dentin sialophosphoprotein-promoted mineralization and expression of odontogenic genes in adipose-derived stromal cells",
        "abstract": "Dentin sialophosphoprotein (DSPP) is an extracellular matrix, typically dentin- and bone-specific gene, which plays an important role in dentin mineralization and tooth development. Adipose-derived stromal cells (ADSCs) are considered to contain a group of pluripotent mesenchymal stem cells which are capable of mineralization either in vitro or in vivo. In the present study, we hypothesized that overexpression of DSPP would promote mineralization in ADSCs. Our results showed that infection of DSPP-expressing adenovirus (Ad-DSPP) enhanced expression of genes related to mineralization, such as Cbfa1,Osx,BSP, OCN and DMP1 in ADSCs. Alkaline phosphatase activity was also confirmed in Ad-DSPP-infected ADSCs by cytochemistry and alkaline phosphatase activity assay. Mineralization assay indicated that Ad-DSPP-infected ADSCs were able to form mineralized nodules. Another finding in this study is that early odontogenic marker genes such as Msx1, Msx2, Lhx7 and Pax9 were expressed in DSPP-overexpressed ADSCs. Thus, our results suggested that overexpression of DSPP promoted mineralization of ADSCs, and together with the expression of early odontogenic marker genes, implied that these cells may differentiate into functional odontoblast-like cells. Copyright \u00a9 2007 S. Karger AG.",
        "keywords": [
            "Adipose-derived stromal cells",
            "Dentin sialophosphoprotein",
            "Mineralization",
            "Mouse",
            "Odontoblast-like cells",
            "Odontogenic genes"
        ],
        "venue": "Cells Tissues Organs",
        "year": 2008,
        "id": "358RWEpR"
    },
    "jLzuULgT": {
        "authors": [
            {
                "name": "Hui Zhou",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Lei Li",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Sheng-Zheng Luo",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Xiao-Bo Cai",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Xin-Jian Wan",
                "org": "Department of Gastroenterology"
            }
        ],
        "title": "Endoscopic sphincterotomy associated cholangitis in patients receiving proximal biliary self-expanding metal stents",
        "abstract": "BACKGROUND: Endoscopic biliary stent placement during the procedure of endoscopic retrograde cholangiopancreatography (ERCP) is preferred to provide biliary drainage for unresectable malignant biliary obstruction. There is considerable controversy over the use of endoscopic sphincterotomy (ES) prior to stent placement. This study aimed to determine whether ES before intraductal self-expanding metal stent (SEMS) placement affects the clinical outcome and complications in patients with proximal malignant obstructive biliary diseases. METHODS: In a prospective randomized controlled trial, 82 patients with inoperable malignant biliary strictures were randomly assigned to biliary stenting groups with or without ES. Resolution of jaundice and the incidence of complications including acute cholangitis, pancreatitis and stent occlusion within 6 months were evaluated. RESULTS: SEMSs were successfully deployed in all patients, resulting in clinical and biochemical improvement of obstructive symptoms in both groups. The incidence of cholangitis was higher in the ES group than in the non-ES group (58.5% vs 31.7%, P=0.015). The interval between stent placement and the first acute cholangitis was much shorter in the ES group than in the non-ES group (P=0.024). The use of ES increased the incidence of cholangitis (P=0.004, risk ratio, 8.196). The rate of post-ERCP pancreatitis after stent placement was greater in the non-ES group than in the ES group (31.7% vs 9.8%, P=0.014). No significant differences were found in the rate of restenosis and the mortality rate between the two groups. CONCLUSIONS: ES prior to intraductal SEMS placement was associated with an increased incidence of acute cholangitis. ES should be carefully evaluated prior to its use in patients with proximal malignant obstructive biliary diseases. \u00a9 2012, Hepatobiliary Pancreat Dis Int.",
        "keywords": [
            "Biliary obstructions",
            "Cholangitis",
            "Endoscopic retrograde cholangiopancreatography",
            "Pancreatitis",
            "Sphincterotomy"
        ],
        "venue": "Hepatobiliary and Pancreatic Diseases International",
        "year": 2012,
        "id": "jLzuULgT"
    },
    "877HBegw": {
        "authors": [
            {
                "name": "Tao Wu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Jian Jiang",
                "org": "Department of Neurosurgery"
            },
            {
                "name": "Xin Zheng",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Syrinx resolution after posterior fossa decompression in patients with scoliosis secondary to Chiari malformation type I",
        "abstract": "Introduction: Description of syrinx resolution after posterior fossa decompression (PFD) in patients with scoliosis secondary to Chiari malformation type I (CMI) and syringomyelia (SM) has been rarely reported in the literature. This study was performed to investigate the outcome of PFD in patients with scoliosis secondary to CMI and to identify potential predictive factors for better outcome after PFD. Material and methods: Patients with scoliosis secondary to CMI and SM, who had undergone PFD during the period 2000 through 2009, were recruited. Inclusion criteria were (1) age \u2264 18 years, (2) diagnosis of SM associated with CMI, (3) scoliosis as the first complaint, (4) having undergone preoperative and follow-up magnetic resonance imaging (MRI). Patients with acquired CMI anomalies or who had received syringosubarachnoid shunting were excluded. The maximal S/C ratio and syrinx length were measured to evaluate syrinx resolution after PFD. A 20% decrease in S/C ratio or length at the latest follow-up was defined as a significant radiographic improvement and complete resolution was used to describe the syrinx disappearing after PFD. Results: 44 patients were recruited. Follow-up MRI was conducted for all 44 patients at 6 \u00b1 3 months postoperatively, for 37 patients at 2 years \u00b1 3 months, for 26 patients at 4 years \u00b1 3 months, and for 15 patients at 6 years \u00b1 3 months. 97.7% (43 of 44) of patients showed significant radiographic improvement by MRI. The distance of tonsillar descent (mm) was correlated significantly with the surgical outcome (r = 0.116, P = 0.013). Significant improvement was observed within 6 months postoperatively, with continued slow improvement after that. Conclusion: Syringes showed significant improvement after PFD in most patients with scoliosis secondary to CMI. Resolution generally occurred within 6 months follow-up and continued at a slow rate for several years. In addition, the severity of tonsillar descent is a potential predictor for better improvement after standard PFD. \u00a9 Springer-Verlag 2011.",
        "keywords": [
            "Chiari malformation type I",
            "Posterior fossa decompression",
            "Resolution",
            "Scoliosis",
            "Syringomyelia",
            "Syrinx"
        ],
        "venue": "European Spine Journal",
        "year": 2012,
        "id": "877HBegw"
    },
    "HBsCpp5q": {
        "authors": [
            {
                "name": "Yong Liu",
                "org": "School of Medicine"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bang-Ping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yitao Ding",
                "org": "Institute of Hepatobiliary Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Validation and reliability analysis of the new SRS-schwab classification for adult spinal deformity",
        "abstract": "Objective. To determine the inter- and intra-observer reliabilities of the new SRS-Schwab system for classifying adult spinal deformity (ASD) using nonpremarked cases. Summary of Background Data. Schwab et al reported excellent inter- and intra-observer reliability and interobserver agreement for classification based on curve type and 3 modifiers. Methods. A total of 102 patients with ASD were included in this study, which was conducted from February 2009 to January 2012. Long-cassette standing posterior-anterior and lateral radiographs of the spine and the pelvis were obtained from patients with ASD in the fist-on-clavicle position. All 102 cases were classified according to the new SRS-Schwab classification by 4 observers. After a 2-week interval, the same classification was independently repeated by each observer with the cases in a different randomly assigned order. The Fless \u03ba coefficient was calculated to test the inter- and intra-observer reliabilities of the new SRS-Schwab classification. Results. With the new SRS-Schwab classification system, 12 patients were classified as having a type T curve, 30 cases as having a type L, 45 cases as having a type D, and 15 cases as having a type S. For overall classification, the mean \u03ba value was 0.73 for interobserver reliability and 0.83 for intraobserver reliability. Disagreements occurred most often when differentiating type T curves from type L curves and when determining the pelvic incidence minus lumbar lordosis modifier. Conclusion. With the nonpremarked cases, this new SRS-Schwab system for patients with ASD could achieve good to excellent intraand inter-observer reliability, but the definition of thoracic or lumbar curves was still predisposed to confusion. Overall, the SRS-Schwab system is a simple and clear classification system with incorporated spinopelvic parameters, which significantly increase its value for practical usage. Copyright \u00a9 2013 Lippincott Williams & Wilkins.",
        "keywords": [
            "Adult deformity",
            "Inter- and intra-observer reliability",
            "Scoliosis",
            "SRS-Schwab classification system"
        ],
        "venue": "Spine",
        "year": 2013,
        "id": "HBsCpp5q"
    },
    "Qr6GPiGS": {
        "authors": [
            {
                "name": "Yun-fei Duan",
                "org": "Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Yan Tan",
                "org": "Department of Pathology, The Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Bo Yuan",
                "org": "Department of Hepatobiliary Surgery, Changzhou TCM Hospital"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Soochow University"
            }
        ],
        "title": "Spontaneous rupture of hepatic metastasis from small cell neuroendocrine carcinoma of maxillary sinus",
        "abstract": "Background: Small cell neuroendocrine carcinoma of the maxillary sinus, a rare malignant tumor, has a poor prognosis because of its high incidence of metastasis. Moreover, metastatic cancer-induced hepatic rupture, characterized by hemoperitoneum, is infrequent, although several lines of evidences have reported that a wide variety of other neoplasms can cause this usually fatal manifestation.Case presentation: We now present the first case of a 49-year-old man with spontaneous rupture of hepatic metastasis from small cell neuroendocrine carcinoma of the maxillary sinus and ultimately resulted in massive intraperitoneal bleeding, which was successfully controlled by subsequent surgery (partial hepatectomy). The postoperative clinical manifestation of the patient was uneventful. He was discharged on the 16th day after operation and without any complication.Conclusions: Small cell neuroendocrine carcinoma of the maxillary sinus is very scarce and unfortunately has a poor prognosis. It has potential to cause spontaneous metastatic rupture which can elicit fatal hemorrhage. Emergency surgery is effective, although the long-term outcome is still unsatisfactory. \u00a9 2014 Duan et al.; licensee BioMed Central Ltd.",
        "keywords": [
            "Hemoperitoneum",
            "Hepatectomy",
            "Hepatic metastases",
            "Maxillary sinus",
            "Small cell neuroendocrine carcinoma"
        ],
        "venue": "World Journal of Surgical Oncology",
        "year": 2014,
        "id": "Qr6GPiGS"
    },
    "GF3H15lP": {
        "authors": [
            {
                "name": "Bang-Ping Qian",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Sai-Hu Mao",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Feng Zhu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Zhen Liu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Lei-Lei Xu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Bing Wang",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yang Yu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yong Qiu",
                "org": "Affiliated Drum Tower Hospital"
            }
        ],
        "title": "Antagonistic role of vertebral translation against vertebral rotation in the spontaneous postoperative modulation of the anterior chest wall contour in thoracic idiopathic scoliosis",
        "abstract": "Study Design. A computed tomography study. Objective. To identify the best scoliotic deformity components that show impact upon the spontaneous postoperative modulation of the deformed anterior chest wall contour in right convex thoracic adolescent idiopathic scoliosis. Summary of Background Data. Spontaneous postoperative aggravation of the anterior concave costal projection was a common occurrence in adolescent idiopathic scoliosis, yet the risk factors that effectively bridged the gap between what the surgeons did in the interior and how the rib cages reacted on the exterior were still open to debate. Methods. Pre- And postoperative computed to mographic scans of 77 patients with right convex thoracic adolescent idiopathic scoliosis were retrieved and analyzed. According to the postoperative variation of anterior chest wall angle (CWA), the patients were divided into 2 groups with either aggravated or improved CWA. Multiple scoliotic deformity parameters and their surgical correction rates were evaluated, correlated, and then compared between the 2 groups. Moreover, patients with apex located at T9 were isolated and evaluated independently. A logistic regression analysis was used to determine the independent predictors of the spontaneous postoperative modulation of the anterior chest wall contour. Results. The surgical correction rate of Cobb angle (supine), the rotational angle with respect to the sagittal plane (RAsag angle), the rotational angle with respect to the anterior midline of the body (RAml angle), the angle of lateral deviation of the apical vertebrae from the midline (MLdev angle), the posterior hemithorax ratio, the vertebral translation (VT), and the thoracic rotation averaged 64.6%, 19.5%, 30.8%, 39.2%, 15.0%, 41.2%, and 28.7%, respectively. Ratio of aggravated anterior chest wall contour was the highest at the T7 apex group (84.6%) as compared with T8 apex group (47.1%), T9 apex group (19.5%), and T10 apex group (0.0%). The preoperative CWA was significantly lower in the aggravated CWA group when compared with the improved group (2.1 \u00b1 1.8 \u00b0 vs . 6.6 \u00b1 2.4 \u00b0 , P < 0.001). Besides, in the aggravated CWA group, significantly greater surgical correction of VT and lesser correction of RAsag angle were demonstrated when compared with the improved CWA group (VT: 53.0% vs . 34.8%, P = 0.001; RAsag: 2.5% vs . 28.7%, P = 0.000). In the T9 subgroup, remarkably different correction rate of VT and RAsag were similarly observed (VT: 54.9% vs . 35.3%, P = 0.046; RAsag: 4.9% vs . 23.5%, P = 0.034). In terms of other deformity parameters, no significantly different correction rate was consistently detected. In the logistic regression analysis, apex location, CWA, and correction rate of RAsag were demonstrated to be independent factors predictive of the alteration of chest wall contour. Conclusion. In addition to the smaller preoperative CWA and higher apex location, lesser correction of vertebral rotation, if accompanied by great surgical correction of apical VT, could also largely result in a poor postoperative anterior chest wall contour. Copyright \u00a9 2013 Lippincott Williams & Wilkins.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Anterior chest wall deformity",
            "Apex location",
            "Vertebral rotation",
            "Vertebral translation"
        ],
        "venue": "Spine",
        "year": 2013,
        "id": "GF3H15lP"
    },
    "F5JJy1nR": {
        "authors": [
            {
                "name": "Xu Sun",
                "org": "Spine Surgery, the Affiliated Drum Tower Hospital"
            },
            {
                "name": "Winnie C.W. Chu",
                "org": "Department of Orthopaedics and Traumatology"
            },
            {
                "name": "Jack C.Y. Cheng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery, the Affiliated Drum Tower Hospital"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery, the Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery, the Affiliated Drum Tower Hospital"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery, the Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery, the Affiliated Drum Tower Hospital"
            }
        ],
        "title": "Do adolescents with a severe idiopathic scoliosis have higher locations of the conus medullaris than healthy adolescents?",
        "abstract": "BACKGROUND:: Based on the \"uncoupled neuro-osseous growth\" theory, the hypothesized etiology of adolescent idiopathic scoliosis (AIS), a shorter spinal cord or a higher conus location, could be found in AIS patients. However, there are no case-control studies with large samples regarding the conus position in AIS patients. This study is performed to determine the positions of the conus medullaris in AIS patients with a large curve magnitude when compared with healthy adolescents and to investigate the relationships of the conus locations with patients' age, sex, curve magnitude, and curve pattern. METHODS:: Two hundred forty AIS patients with a Cobb angle greater than 40 degree were included in this study, and 120 age-matched healthy adolescents were recruited to serve as controls. Both AIS patients and healthy controls displayed normal on neurological examinations. On sagittal magnetic resonance images of the spine in both groups, the position on the conus medullaris relative to lumbar vertebrae and intervertebral disk space was measured according to a standard method. RESULTS:: There was no significant difference in the distributions of the positions of the conus medullaris in AIS patients and healthy controls (P = 0.448). In both groups, the mean position of the conus medullaris was located at the same level, which was the lower 1/3 of L1 (range: the middle third of T12 to L2-3 disk space). The conus positions were neither significantly different among adolescents of different ages (P = 0.662 in AIS and P = 0.897 in controls) nor between boys and girls (P = 0.875 in AIS and P = 0.675 in controls). It was shown that the conus position was not significantly different among AIS patients with different curve severity (F = 0.314, P = 0.731) and curve patterns (F = 0.097, P = 0.756). CONCLUSIONS:: The mean and the distribution of the conus locations were similar for AIS patients and the controls. No significant associations of the conus position with curve severity and with curve patterns were found, indicating that the conus location might not be involved in the pathogenesis and curve progression of AIS. LEVEL OF EVIDENCE:: Level III. \u00a9 2008 by Lippincott Williams and Wilkins.",
        "keywords": [
            "Adolescent",
            "Conus medullaris",
            "Idiopathic scoliosis",
            "Magnetic resonance imaging",
            "Measurement"
        ],
        "venue": "Journal of Pediatric Orthopaedics",
        "year": 2008,
        "id": "F5JJy1nR"
    },
    "BahKdZHL": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Antai College of Economic and Management"
            }
        ],
        "title": "Generation unit maintenance market design during economy transition period in China",
        "abstract": "This paper focuses on unit maintenance market design in the transition period of power market. The maintenance market design scheme is easy to transit from the unit maintenance approval mechanism by planning mode into market mechanism. Every unit owns maintenance right and the first step of maintenance market mechanism is to transform the maintenance right for unit into fictitious money. Then the maintenance right market is established in some special period for a year. Generators bid in the right market with the fictitious money allocated. The bidding result decides the maintenance plan in a year for every unit. This paper also proposes a monthly adjustment mechanism for maintenance plan decided by market, and suggests a premium and punishment scheme for maintenance behavior of unit in the end of year. Finally, a simple example is given to demonstrate the introduced maintenance market mechanism.",
        "keywords": [
            "Maintenance plan",
            "Maintenance right",
            "Power market",
            "Transition economy"
        ],
        "venue": "Dianli Xitong Zidonghua/Automation of Electric Power Systems",
        "year": 2007,
        "id": "BahKdZHL"
    },
    "sm0xur6a": {
        "authors": [
            {
                "name": "Meihong Cai",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Pingping Shen",
                "org": ""
            }
        ],
        "title": "Expression and purification of chicken beta interferon and its antivirus immunological activity",
        "abstract": "Interferon beta (IFN-\u03b2) belongs to a class of natural proteins that can inhibit virus replication. In this paper, nucleic acid sequence encoding chicken interferon beta (chIFN-\u03b2) mature protein was cloned and highly expressed in Escherichia coli (E. coli) by 1 mM IPTG induction. The expressed chIFN-\u03b2 was about 20% of total bacterial protein. The recombinant protein in form of inclusion body was then solubilised, refolded and purified to a purity of greater than 95% by immobilized metal ion affinity chromatography (IMAC). This recombinant chIFN-\u03b2 could inhibit vesicular stomatitis Indiana virus (VSV) and infectious bursal disease virus (IBDV) replication in vitro. Animal experiments showed that the recombinant chIFN-\u03b2 could decrease pathological lesions caused by the IBDV in bursa of Fabricius. These results will provide useful information for further investigations on veterinary clinical applications and fundamental research. \u00a9 2012 Elsevier Inc. All rights reserved.",
        "keywords": [
            "Expression",
            "IBDV",
            "Interferon beta",
            "Pathological lesion",
            "VSV"
        ],
        "venue": "Protein Expression and Purification",
        "year": 2012,
        "id": "sm0xur6a"
    },
    "L8LbUymm": {
        "authors": [
            {
                "name": "Ru-Ling Zhang",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Li Cheng",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Xiao-Bo Cai",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Hang Zhao",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Xin-Jian Wan",
                "org": "Department of Gastroenterology"
            }
        ],
        "title": "Comparison of the safety and effectiveness of endoscopic biliary decompression by nasobiliary catheter and plastic stent placement in acute obstructive cholangitis",
        "abstract": "BACKGROUND: Endoscopic retrograde biliary drainage (ERBD) using a plastic stent is suggested to be as effective as endoscopic nasobiliary drainage (ENBD) with a nasobiliary catheter for temporary biliary drainage in acute obstructive cholangitis. However, there are few studies that have compared the two methods. We therefore compared the safety and effectiveness of endoscopic biliary decompression by nasobiliary catheter versus plastic stent placement in these patients. METHODS: A total of 94 screened patients with acute obstructive cholangitis were randomised to undergo emergency endoscopic biliary drainage with ENBD (n = 47) or ERBD (n = 47). Clinical outcomes and adverse events were compared. RESULTS: Patient backgrounds were similar in the two groups. Endoscopic biliary drainage was successfully achieved in all patients. Eleven patients underwent unscheduled endoscopic retrograde cholangiopancreatography (ERCP) to replace the nasobiliary catheter, 10 due to a catheter (1 in the ENBD group) or stent (9 in the ERBD group) blockage and 1 due to catheter migration. Clinical manifestations were similar, however, there was a significantly lower patient discomfort score in the ERBD group (p <0.05). The mean serum gamma-glutamyltransferase and total bilirubin concentrations after ERCP were significantly higher in the ERBD than ENBD group (p <0.001). Complication rates were similar in the ENBD and ERBD groups. However, the incidence rate of blockage in ERBD was statistically higher than ENBD (p = 0.015). CONCLUSIONS: Endoscopic biliary decompression is an effective treatment for patients with acute obstructive cholangitis. In contrast to other studies, we found an increased rate of blockage in the ERBD group and a greater decrease in liver enzyme levels in the ENBD group.",
        "keywords": [
            "Acute obstructive cholangitis",
            "Endoscopic biliary decompression",
            "Nasobiliary catheter",
            "Plastic stent placement"
        ],
        "venue": "Swiss Medical Weekly",
        "year": 2013,
        "id": "L8LbUymm"
    },
    "iG4smJzc": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangpin Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            },
            {
                "name": "Weiwei Ma",
                "org": "Spine Surgery"
            }
        ],
        "title": "Comparison of surgical outcomes of lenke type 1 idiopathic scoliosis: Vertebral coplanar alignment versus derotation technique",
        "abstract": "STUDY DESIGN: Prospective clinical study. OBJECTIVE: To compare the surgical outcomes of vertebral coplanar alignment (VCA) technique against the derotation maneuver with segmental pedicle screw instrumentation in patients with Lenke type 1 idiopathic scoliosis. SUMMARY OF BACKGROUND DATA: Nowadays the majority of scoliosis correction begins with rod rotation and translation from the concave side, which bears potential neurovascular risks. The technique of VCA was introduced by Vallespir with the intention of correcting rotation and translation and restoring the normal sagittal profile of thoracic scoliosis simultaneously. METHODS: The fusion levels were decided according to the Lenke criteria. In group A (24 cases), the VCA technique was used. The pedicle screws were inserted at each vertebral level on the convex side and at every other level on the concave side, an extended coplanar tube was secured in line with screw axis to each pedicle screw. Two rigid bars were inserted through the top of the slotted tube. The first rod was kept in this position, whereas the second bar was gently driven down through the slotted tube toward the bottom end. This causes the pedicle screws to align in the sagittal plane, and hence, correct both translation and rotation. The thoracic kyphosis was restored with spacers, which separate the coplanar tubes apart. The derotation maneuver was applied in group B (24 cases). Multiple clinical and radiographic parameters were evaluated and compared. RESULTS: The preoperative data were similar between the 2 groups in terms of age, sex, Risser sign, and curve magnitude. In group A, the coronal Cobb angle was corrected from an average of 58 to 16 degrees with a correction rate of 71.8%, and the thoracic kyphosis was restored from an average of 18 to 28 degrees. In group B, the coronal Cobb angle was reduced from 55 to 17 degrees with a correction rate of 68.4%, and the thoracic kyphosis was increased from an average of 15 to 18 degrees. Patients were followed for an average of 17 months (14 to 20 mo) with both groups showing no significant loss of correction. There were no vascular or neurological complications related to pedicle screw insertion or scoliosis correction. Two screws pullout occurred on the concave side in group B. There was 1 case of hemothorax related to a thoracoplasty procedure in group B. No pseudarthrosis occurred during follow-up in both the groups. CONCLUSIONS: In treating thoracic scoliosis, the VCA technique could achieve as good correction and clinical outcome as the derotation technique. The advantage lies in its superior renormalization effect of thoracic kyphosis compared with the derotation technique from the concave side. Copyright \u00a9 2011 by Lippincott Williams & Wilkins.",
        "keywords": [
            "Idiopathic scoliosis",
            "Internal fixation",
            "Pedicle screw",
            "Spinal fusion"
        ],
        "venue": "Journal of Spinal Disorders and Techniques",
        "year": 2011,
        "id": "iG4smJzc"
    },
    "wAW6SiJW": {
        "authors": [
            {
                "name": "Sai-Hu Mao",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bing Wang",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Clinical evaluation of the anterior chest wall deformity in thoracic adolescent idiopathic scoliosis",
        "abstract": "Study Design. A retrospective radiographical study of pre-and postoperative anterior chest wall shape in thoracic adolescent idiopathic scoliosis. Objective. To assess the anterior chest wall deformity and define its relationship with other deformed components in adolescent idiopathic scoliosis. The surgical influence on the deformed chest wall contour was also evaluated to improve the clinical recognition of the risk factors associated with aggravated chest wall shape postoperatively. Summary of Background Data. Anterior chest wall deformity is one of the major cosmetic concerns that may be attributable to rotational coupling in adolescent idiopathic scoliosis. Patients could be quite different in their anterior chest wall appearance with similar spinal angulation. The surgical improvement of this deformed chest wall shape is also quite elusive and the reverse could also happen despite excellent correction in Cobb angle. We investigated whether or not the anterior chest wall deformity was independent in the severity from the codevelopment of spinal curvature, translation, and vertebral rotation. Methods. In this retrospective study, 110 sets of computed tomographic scans, 70 of which had both pre-and postoperative images, were retrieved and analyzed. The ImageJ software (National Institutes of Health, Bethesda, MD) was used to manipulate formatted computed tomographic scans into 3-dimensional anterior chest wall reconstructions. Multiple anterior and posterior deformity parameters were evaluated, correlated, and compared. Results. The preoperative Cobb angle of major thoracic curve, chest wall angle (CWA), rib hump (RH), angle of the sternum relative to the apical vertebral body (\u03b1), sternum-rib ratio (S-R ratio), apical vertebral rotation (AVR), and angle of trunk rotation (ATR) averaged 54.4\u00b0\u00b1 15.2\u00b0, 5.4\u00b0\u00b1 3.9\u00b0, 14.7\u00b0\u00b1 5.4\u00b0, 80.5\u00b0\u00b1 7.8\u00b0, 1.3\u00b0\u00b1 0.2, 12.3\u00b0\u00b1 6.5\u00b0, and 8.8\u00b0\u00b1 4.6\u00b0, respectively. The thoracic Cobb angle demonstrated moderate correlation with CWA, RH, \u03b1, S-R ratio, AVR, and ATR (r = 0.377, 0.604,-0.401, 0.514, 0.530, and 0.517, respectively, P < 0.001). The RH demonstrated moderate correlation with AVR (r = 0.546, P < 0.001). No statistically significant relationships between CWA and RH, AVR, and ATR were detected (r = 0.129, 0.043,-0.039, P > 0.05). The AVR demonstrated significant correlation with \u03b1 and S-R ratio (r =-0.757, P < 0.001; r = 0.213, P < 0.05). Averaged CWA with different curve apex showed a normal distribution shape, with the highest at T9 level. The postoperative thoracic Cobb angle, S-R ratio, AVR, and ATR improved significantly (P < 0.05), with the exception of the postoperative CWA and \u03b1 (P > 0.05). Postoperative |CWA| aggravated in 52.8% of the patients, with 38.6% beyond 5\u00b0, which showed a significantly lower average preoperative CWA (3.0\u00b0\u00b1 2.8\u00b0) compared with the rest of patients with decreased CWA (7.9 \u00b1 3.1\u00b0) (P < 0.001). Conclusion. Idiopathic scoliosis is associated with distinctive anterior chest wall deformity, with its variations partially attributable to Cobb angle and apex location, but not directly correlated with AVR. Incidence of aggravated postoperative anterior chest wall shape is notable in our study, and patients should be informed of this risk beforehand. Small preoperative CWA and apical vertebra located above T9 were associated with relatively higher risk of postoperative chest wall shape aggravation. \u00a9 2012 Lippincott Williams & Wilkins.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "Anterior chest wall deformity",
            "apical vertebral rotation",
            "rib hump"
        ],
        "venue": "Spine",
        "year": 2012,
        "id": "wAW6SiJW"
    },
    "DVeKtS6G": {
        "authors": [
            {
                "name": "Xu-Sheng Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhi-Wei Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Wei-Jun Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Sai-Hu Mao",
                "org": "Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bang-Ping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Shou-Feng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Jun Qiao",
                "org": "Spine Surgery"
            }
        ],
        "title": "Preoperative pelvic axial rotation: A possible predictor for postoperative coronal decompensation in thoracolumbar/lumbar adolescent idiopathic scoliosis",
        "abstract": "Background: The pelvis as the biomechanical foundation of spine, plays an important role in the balance of the stance and gait through the multi-link spinal-pelvic system. If the pelvic axial rotation (PAR) exists in adolescent idiopathic scoliosis (AIS) patients, it should theoretically have some effects on the body balance. Purpose: To explore the probable effects of preoperative PAR on the spinal balance in coronal plane in AIS patients with main thoracolumbar/lumbar (TL/L) curve after posterior spinal instrumentation. Methods: Thirty-eight AIS patients (age: 15 \u00b1 1.5 years) with main TL/L curve (51 \u00b1 6.2) were recruited retrospectively into this study. The mean follow-up period was 27 months (24-36 months). Standing full spine posteroanterior radiographs were taken preoperatively, 3 month and 1 year postoperatively, and at last follow-up. The convex/concave ratio (CV/CC ratio) of the anterior superior iliac spine laterally and the inferior ilium at the sacroiliac joint medially was measured on posteroanterior radiographs. According to the preoperative CV/CC ratios, the patients were divided into two groups: normal group (N-group: 0.95 \u2264 CV/CC \u2264 1.05); and the asymmetrical group (A-group: CV/CC < 0.95, or >1.05). Results: In all the patients, the 3-month-postoperative CV/CC ratio (1.026 \u00b1 0.087) was significantly different from the preoperative CV/CC ratio (0.969 \u00b1 0.095, P < 0.001), indicating that the pelvis had rotated in the opposite direction of the corrective derotation load applied to the TL/L spine after surgery. No significant change was found in the CV/CC ratio from 3-month-postoperative to the last follow-up (1.013 \u00b1 0.103, P > 0.05). There was no significant difference in the demographic, phenotypic, and treatment variables between the N- (n = 16) and A-groups (n = 22) (P > 0.05). However, more coronal decompensation occurred in the A-group after surgery (36.4 vs. 0.0 %, P = 0.013): two patients having trunk translation, three having lower instrumented vertebra (LIV) translation, and one having LIV tilt; meanwhile, one patient having both LIV translation and LIV tilt, and one having both trunk translation and LIV tilt. Conclusions: The present study confirmed the existence of PAR in AIS patients, and indicated that the pelvis would experience an active rebalancing in the transverse plane within 3 months after spinal correction, and since then, its position would remain stable. Moreover, TL/L-AIS patients with preoperative asymmetrical PAR probably had greater risk of coronal decompensation postoperatively. \u00a9 2013 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "Decompensation",
            "Idiopathic scoliosis",
            "Pelvis",
            "Rotation",
            "Transverse plane"
        ],
        "venue": "European Spine Journal",
        "year": 2013,
        "id": "DVeKtS6G"
    },
    "7Byb9tf6": {
        "authors": [
            {
                "name": "Yun-Fei Duan",
                "org": ""
            },
            {
                "name": "Bo Yang",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            }
        ],
        "title": "Traumatic rupture of a type IVa choledochal cyst in an adult male",
        "abstract": "Choledochal cyst (CC) is a rare, congenital anomaly of the bile ducts. We describe a 26-year-old male patient who was transferred to our hospital with a reported traumatic rupture of cystic liver lesions following a fall. At the time of injury, the patient experienced severe abdominal pain. He was found to have peritonitis and abdominal hemorrhage, which is quite rare. Laparot-omy revealed 3000 mL fuid consisting of a mixture of blood, bile and infammatory effusion in the peritoneal cavity. The liver, gallbladder, spleen, stomach, duodenum, small intestine, and colon appeared normal. A large cystic mass was discovered near the porta hepatis. This mass, which connected to the hepatic bifurcation and gallbladder had a 5 cm rupture in the right wall with active arterial bleeding. Abdominal computed tomography (CT) and emergency laparotomy revealed rupture of a huge type IVa CC. The patient was successfully managed by primary cyst excision, cholecystectomy, and Roux-en-Y end-to-side hepatico-jejunostomy reconstruction. The postoperative course was uneventful and the patient was discharged on the 12",
        "keywords": [
            "Biliary tract",
            "Choledochal cyst",
            "Hemorrhage",
            "Peritonitis",
            "Rupture",
            "Trauma"
        ],
        "venue": "World Journal of Gastroenterology",
        "year": 2013,
        "id": "7Byb9tf6"
    },
    "DDtyrKZn": {
        "authors": [
            {
                "name": "Leilei Xu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Xu Sun",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Shushu Huang",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Jun Qiao",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Feng Zhu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Saihu Mao",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yitao Ding",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yong Qiu",
                "org": "Affiliated Drum Tower Hospital"
            }
        ],
        "title": "Degenerative lumbar scoliosis in Chinese Han population: Prevalence and relationship to age, gender, bone mineral density, and body mass index",
        "abstract": "Purpose: To investigate the prevalence of degenerative lumbar scoliosis (DLS) in Chinese Han population, as well as its correlation with age, gender, bone mineral density (BMD), and body mass index (BMI); and to determine factors that might affect the curve severity. Methods: A prospective study was performed on adults visiting the dual-energy X-ray absorption clinics for physical examination from January 2011 to March 2012. 2,395 subjects aged older than 40 years and having no history of previous spinal trauma, surgeries or scoliosis, were enrolled in this study. A logistic regression analysis was performed to determine the independent variables related to the presence of scoliosis. Besides, the relationship between curve severity and these variables was also analyzed with partial linear correlation analysis. Results: The prevalence of DLS was approximately 13.3 %. The logistic regression analysis showed that age, T score, and gender all had remarkable correlation with the occurrence of DLS, with the odd ratios being 4.2, 1.5, and 1.6, respectively. According to the receiver operating characteristics curve, the best dividing point for age and T score of female subjects was 65 and -2.0, respectively. Partial linear correlation analysis indicated that there existed no obvious correlation between the above variables and the severity of scoliosis. Conclusion: The prevalence of DLS in Chinese Han population aged older than 40 years was approximately 13.3 %, which had a significant correlation with age, gender, and BMD. Osteopenia, gender of female, and aged older than 65 years could contribute to the presence of DLS. The curve severity was not associated with age, gender, BMI, or BMD. \u00a9 2013 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "Curve severity",
            "Degenerative lumbar scoliosis",
            "Osteopenia",
            "Prevalence"
        ],
        "venue": "European Spine Journal",
        "year": 2013,
        "id": "DDtyrKZn"
    },
    "DrEfx3i9": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Yanxiang Sun",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Min Wang",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Shihui Ma",
                "org": "Zhongshan Hospital"
            },
            {
                "name": "Xiao Chen",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Ailin Cao",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Fen Chen",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Yan Qiu",
                "org": "Department of Cardilogy"
            },
            {
                "name": "Yuhua Liao",
                "org": "Department of Cardilogy"
            }
        ],
        "title": "Correlation between HLA-DRB1, HLA-DQB1 Polymorphism and Autoantibodies Against Angiotensin AT",
        "abstract": "Background: The autoantibodies (AAs) against angiotensin AT",
        "keywords": [
            ""
        ],
        "venue": "Clinical Cardiology",
        "year": 2011,
        "id": "DrEfx3i9"
    },
    "m3Bu0wLP": {
        "authors": [
            {
                "name": "Mei-hong Cai",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University"
            },
            {
                "name": "Feng Zhu",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University"
            },
            {
                "name": "Hao-chen Wu",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University"
            },
            {
                "name": "Ping-ping Shen",
                "org": "State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University"
            }
        ],
        "title": "A new recombinant hybrid polypeptide and its immunologic adjuvant activity for inactivated infectious bursal disease vaccine",
        "abstract": "Both bursin (Lys-His-Gly-NH",
        "keywords": [
            "Bursin",
            "Expression",
            "Gagnon's peptide",
            "Immune adjuvant",
            "Infectious bursal disease virus vaccine",
            "Recombinant hybrid polypeptide"
        ],
        "venue": "Biotechnology Letters",
        "year": 2014,
        "id": "m3Bu0wLP"
    },
    "focDu9dt": {
        "authors": [
            {
                "name": "Zhong-Wei Zhang",
                "org": ""
            },
            {
                "name": "Jian Cheng",
                "org": ""
            },
            {
                "name": "Fei Xu",
                "org": ""
            },
            {
                "name": "Yang-Er Chen",
                "org": ""
            },
            {
                "name": "Jun-Bo Du",
                "org": ""
            },
            {
                "name": "Ming Yuan",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Xiao-Chao Xu",
                "org": ""
            },
            {
                "name": "Shu Yuan",
                "org": ""
            }
        ],
        "title": "Red blood cell extrudes nucleus and mitochondria against oxidative stress",
        "abstract": "Mammal red blood cells (erythrocytes) contain neither nucleus nor mitochondria. Traditional theory suggests that the presence of a nucleus would prevent big nucleated erythrocytes to squeeze through these small capillaries. However, nucleus is too small to hinder erythrocyte deformation. And, there is no sound reason to abandon mitochondria for the living cells. Here, we found that mammal erythrocyte reactive oxygen species (ROS) levels kept stable under diabetes, ischemia reperfusion, and malaria conditions or in vitro sugar/heme treatments, whereas bird erythrocyte ROS levels increased dramatically in these circumstances. Nuclear and mitochondrial extrusion may help mammal erythrocytes to better adapt to high-sugar and high-heme conditions by limiting ROS generation. \u00a9 2011 IUBMB.",
        "keywords": [
            "erythrocytes",
            "mitochondria",
            "nucleus",
            "reactive oxygen species"
        ],
        "venue": "IUBMB Life",
        "year": 2011,
        "id": "focDu9dt"
    },
    "nNPvHSu2": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Xiaochen Qiu",
                "org": ""
            },
            {
                "name": "Junjie Wang",
                "org": ""
            },
            {
                "name": "Yichao Jin",
                "org": ""
            },
            {
                "name": "Yu Sun",
                "org": ""
            },
            {
                "name": "Tao Lv",
                "org": ""
            },
            {
                "name": "Zhaofan Xia",
                "org": ""
            }
        ],
        "title": "A rat model of smoke inhalation injury",
        "abstract": "Context: Smoke inhalation injury is the leading cause of acute respiratory failure in critical burn victims. Advances in the treatment of smoke inhalation injury have been limited in the past years. To further explore the pathogenesis, stable and practical animal models are necessary. Objective: To develop a rat model of smoke inhalation injury. Materials and methods: The smoke composition including the particulate matters, irritant gases, chemical carcinogens was measured. The blood gas values, pro-inflammatory and protein concentration in bronchoalveolar lavage fluid and lung wet to dry weight ratio were assayed. Pathological evaluations of pulmonary were performed at 24 h, 96 h, 7 days and 28 days post-injury. MassonGoldner trichrome staining was performed on day 7 and 28 post-injury, along with the measurement of hydroxyproline and collagen I and III. Results: In our present animal model, smoke inhalation caused a significant hypoxemia and CO poisoning. A surge of pro-inflammatory response and microvascular hyperpermeability with neutrophils accumulations were also found in our animal model. At 24 h post-smoke inhalation, the hematoxylin and eosin results exhibited that there were inflammatory exudates and diffuse hemorrhage in the lung tissue with significant edema. With the time going, the lung injuries appeared at alveolar collapse and alveolar septum thickening, which indicated that smoke inhalation further induced damage to lung parenchyma. Specially, the markedly collagen deposition appeared at 28 days post-injury indicated that pulmonary fibrosis happened. Discussion and conclusion: In conclusion, this rat smoke inhalation injury model induced by our novel self-made smoke generator could be used for acute and chronic lung injury experiments. \u00a9 2012 Informa Healthcare USA, Inc.",
        "keywords": [
            "Animal model",
            "Rat",
            "Smoke inhalation injury"
        ],
        "venue": "Inhalation Toxicology",
        "year": 2012,
        "id": "nNPvHSu2"
    },
    "1YZlUtxa": {
        "authors": [
            {
                "name": "Xiao Wang",
                "org": "Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science"
            },
            {
                "name": "Zhong-Wei Zhang",
                "org": "College of Resources and Environmental Sciences"
            },
            {
                "name": "Shi-Hua Tu",
                "org": "Soil and Fertilizer Institute"
            },
            {
                "name": "Wen-Qiang Feng",
                "org": "Soil and Fertilizer Institute"
            },
            {
                "name": "Fei Xu",
                "org": "Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science"
            },
            {
                "name": "Feng Zhu",
                "org": "Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science"
            },
            {
                "name": "Da-Wei Zhang",
                "org": "Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science"
            },
            {
                "name": "Jun-Bo Du",
                "org": "Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Science"
            },
            {
                "name": "Shu Yuan",
                "org": "College of Resources and Environmental Sciences"
            },
            {
                "name": "Hong-Hui Lin",
                "org": "State Key Laboratory of Hydraulics and Mountain River Engineering"
            }
        ],
        "title": "Comparative study of four rice cultivars with different levels of cadmium tolerance",
        "abstract": "Cadmium (Cd) has been identified as a significant pollutant due to its high solubility in water and soil and high toxicity to plants and animals. Rice, as one of the most important food crops, is grown in soils with variable levels of Cd and therefore, is important to discriminate the Cd tolerance of different rice cultivars to determine their suitability for cultivation in Cd-contaminated soils. This study investigates the primary mechanisms employed by four rice cultivars in attaining Cd tolerance. HA63 cultivar reduces Cd uptake by increasing Fe absorption through activation of phytosiderophores. T3028 cultivar accumulates the highest level of Cd in leaves while also activating its reactive oxygen species (ROS) scavenging system, including antioxidant enzymes and phytochelatins. In some rice cultivars (such as HA63), a cyanide-resistant respiration mechanism, important in Cd detoxification, was also promoted under the Cd stress. In conclusion, different rice cultivars may adopt different biochemical strategies and respond with different efficiency to Cd stress. \u00a9 2013 Versita Warsaw and Springer-Verlag Wien.",
        "keywords": [
            "antioxidant enzymes",
            "cadmium tolerance",
            "cyanide-resistant respiration",
            "phytochelatin",
            "phytosiderophore"
        ],
        "venue": "Biologia (Poland)",
        "year": 2013,
        "id": "1YZlUtxa"
    },
    "ExmIsJgY": {
        "authors": [
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Juan Xiao",
                "org": ""
            },
            {
                "name": "Min Shen",
                "org": ""
            },
            {
                "name": "Yu Yahong",
                "org": ""
            },
            {
                "name": "Rui Tian",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Jianxin Jiang",
                "org": ""
            },
            {
                "name": "Zhiyong Du",
                "org": ""
            },
            {
                "name": "Jun Hu",
                "org": ""
            },
            {
                "name": "Wensong Liu",
                "org": ""
            },
            {
                "name": "Renyi Qin",
                "org": ""
            }
        ],
        "title": "Isolation and characterization of tumorigenic extrahepatic cholangiocarcinoma cells with stem cell-like properties",
        "abstract": "Recent studies suggest that the ability to form and grow tumors specifically resides in a small cell population called cancer stem cells (CSCs). These studies were conducted mainly on various human cancers; however, isolation and characterization of stem cells from cholangiocarcinoma have not been attempted. The molecular markers CD24, CD44, CD34, and epithelial cell adhesion molecule (EpCAM) are widely used, individually or in combination, to characterize some types of CSCs. In this study, we used these markers to identify a subpopulation of cells in extrahepatic cholangiocarcinoma (ECC) with cancer stem/progenitor cell-like properties. We found that CD24 ",
        "keywords": [
            "Bile ducts",
            "Cancer stem cell",
            "CD24",
            "CD34",
            "CD44",
            "Cholangiocarcinoma",
            "EpCAM"
        ],
        "venue": "International Journal of Cancer",
        "year": 2011,
        "id": "ExmIsJgY"
    },
    "fKgRTsOZ": {
        "authors": [
            {
                "name": "Bo Wen",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Zhen Li",
                "org": ""
            },
            {
                "name": "Peng Zhang",
                "org": ""
            },
            {
                "name": "Xingnan Lin",
                "org": ""
            },
            {
                "name": "Michel Dard",
                "org": ""
            }
        ],
        "title": "The osseointegration behavior of titanium-zirconium implants in ovariectomized rabbits",
        "abstract": "Objective: The aim of this study is to compare the osseointegration behavior of titanium (Ti) and titanium-zirconium (TiZr) implants in ovariectomized (OVX) rabbits. Materials and methods: Twelve ovariectomized New Zealand rabbits submitted to a hypocalcic diet and 12 sham-aged rabbits were used. After the bone mass loss induction period, TiZr or Ti implants both benefiting from a SLActive surface treatment were randomly inserted in the tibia and femur of each animal. The total of 24 rabbits were divided in four groups (n = 6): SHAM + Ti, OVX + Ti, SHAM + TiZr,OVX + TiZr. The animals were respectively sacrificed 3 and 6 weeks after dental implant placement. Six implants in each group at each time point were subjected to removal torque testing, and the remaining implants were prepared for histomorphometric analysis. Results: At the end of the healing period, all implants were osseointegrated. The removal torque value of the SHAM-TiZr group was significantly higher than those of the SHAM-Ti group (P < 0.001). The removal torque of the OVX-Ti group was significantly lower than those of the OVX-TiZr group. All groups demonstrated an increase in the peak torque value after 6 weeks: 46.0 and 50.8 Ncm for the OVX and the SHAM animals, respectively, in the case where Ti implants were used. When TiZr implants were inserted, the values reached 60.7 and 76.2 Ncm with a similar group configuration. The BIC and the BA/TA analysis showed an increase between week 3 and 6 in the case of nonovariectomized animals. From week 3 to 6, the BIC went from 37.1 \u00b1 14.3 to 47.7 \u00b1 8.7 for the SHAM + Ti group and from 37.6 \u00b1 10.9 to 50.4 \u00b1 11 for the SHAM + TiZr group. The BIC values were not significantly different between groups. Conclusion: The parameters intended to be representative of the bone morphology (BIC & BATA) did not help to discriminate between Ti and TiZr which appeared to behave similarly in this experimental model. However, the removal torque values for the TiZr group were statistically higher than those of the Ti group in both the SHAM and the ovariectomized animals. That likely reflected an increased quality of bone around the TiZr implants. \u00a9 2013 John Wiley & Sons A/S.",
        "keywords": [
            "Osseointegration",
            "Osteoporosis",
            "Ovariectomized rabbits",
            "SLActive implants",
            "Titanium-zirconium implants"
        ],
        "venue": "Clinical Oral Implants Research",
        "year": 2014,
        "id": "fKgRTsOZ"
    },
    "7i7Asa8b": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Shanghai Jiaotong University"
            }
        ],
        "title": "Impacts of transition of economy on electricity market construction in China",
        "abstract": "Some impacts on electricity market construction in China during transition of economy are analyzed, and the competitive transition mode and relative risk prevention measures are proposed. It indicates that, since Chinese electricity market owns some specific realities such as market power of state-owned enterprises, government macroscopically economy regulating, electricity industry being in the fast period of expansion, energy saving and environmental protection and so on. During the transition period of economy, electricity market construction in china should have some predominant characteristics compared with other countries. At the same time, the transitional competition mode is proposed, and a risk prevention framework has been advanced includes three aspects: power system security, market power and market participants' management risk. Furthermore, this paper proposes that hedging can be an effective means for electricity market in transition period of economy.",
        "keywords": [
            "Competition model",
            "Electricity market",
            "Hedging",
            "Risk prevention",
            "Transition of economy"
        ],
        "venue": "Dianli Xitong Zidonghua/Automation of Electric Power Systems",
        "year": 2007,
        "id": "7i7Asa8b"
    },
    "4nbyZUGL": {
        "authors": [
            {
                "name": "Shouyu He",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Hongda Bao",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Hengcai Zhou",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Bin Wang",
                "org": "Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School"
            }
        ],
        "title": "Vertebral coplanar alignment technique: a surgical option for correction of adult thoracic idiopathic scoliosis",
        "abstract": "Purpose: Previous studies have demonstrated vertebral coplanar alignment (VCA) as an effective surgical option for adolescent idiopathic scoliosis (AIS). The purpose of this study is to analyze the outcome of VCA for the surgical correction of adult idiopathic scoliosis (AdIS). Methods: 35 AdIS patients (mean age: 24.2 years) undergoing VCA-instrumentation were reviewed. The main thoracic curve and thoracic kyphosis (TK, T5-T12) were evaluated preoperatively, immediate postoperatively, and at the final follow-up (>1 year). All patients were stratified by the TK modifier before surgery: \u201c+\u201d (TK, >40\u00b0), \u201c\u2212\u201d (TK, <10\u00b0), and \u201cN\u201d (TK, 10\u00b0\u201340\u00b0) for normal. The apical vertebral body-to-rib ratio (AVB-R), rib hump (RH), and rotational angle to sacrum (RAsac) were measured to assess the correction of rotational deformity. Quality of life was evaluated with SRS-20 questionnaires. Results: The main thoracic curve (59.1\u00b0 vs. 19.3\u00b0, P < 0.001) and rotational deformity (AVB-R: 2.4 vs. 1.7 %, P < 0.001, RH: 34.9 vs. 19.1 mm, P < 0.001, RAsac: 19.6\u00b0 vs. 11.9\u00b0, P < 0.001) were significantly reduced with surgery. Sagittal deformity improved significantly in group \u201c+\u201d (51.4\u00b0 vs. 31.6\u00b0, P < 0.001) and group \u201c\u2212\u201d (6.2\u00b0 vs. 20.1\u00b0, P < 0.001), while no significant postoperative change in TK was observed in group \u201cN\u201d (23.5\u00b0 vs. 26.3\u00b0, P = 0.270). Patients were followed for an average of 18.7 months with no significant loss of correction. SRS scores improved greatly from 57.7 preoperatively to 71.6 at the final follow-up. Conclusions: VCA can be effectively used for the correction of the coronal and rotational deformity, with better sagittal profile restoration in adult thoracic idiopathic scoliosis with sagittal malalignment.",
        "keywords": [
            "Idiopathic scoliosis",
            "Thoracic kyphosis",
            "Vertebral coplanar alignment"
        ],
        "venue": "European Spine Journal",
        "year": 2015,
        "id": "4nbyZUGL"
    },
    "cSkryyyk": {
        "authors": [
            {
                "name": "Khay-Guan Yeoh",
                "org": "Department of Medicine"
            },
            {
                "name": "Khek-Yu Ho",
                "org": "Department of Medicine"
            },
            {
                "name": "Han-Mo Chiu",
                "org": "Department of Internal Medicine"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Medicine"
            },
            {
                "name": "Jessica Y. L. Ching",
                "org": "Department of Medicine and Therapeutics"
            },
            {
                "name": "Deng-Chyang Wu",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Takahisa Matsuda",
                "org": "Endoscopy Division"
            },
            {
                "name": "Jeong-Sik Byeon",
                "org": "Department of Internal Medicine"
            },
            {
                "name": "Sang-Kil Lee",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Khean-Lee Goh",
                "org": "Department of Gastroenterology and Hepatology"
            },
            {
                "name": "Jose Sollano",
                "org": "Department of Gastroenterology"
            },
            {
                "name": "Rungsun Rerknimitr",
                "org": "Department of Internal Medicine"
            },
            {
                "name": "Rupert Leong",
                "org": "Department of Medicine"
            },
            {
                "name": "Kelvin Tsoi",
                "org": "Department of Medicine and Therapeutics"
            },
            {
                "name": "Jaw-Town Lin",
                "org": "Department of Internal Medicine"
            },
            {
                "name": "Joseph J. Y. Sung",
                "org": "Department of Medicine and Therapeutics"
            }
        ],
        "title": "The Asia-Pacific Colorectal Screening score: A validated tool that stratifies risk for colorectal advanced neoplasia in asymptomatic Asian subjects",
        "abstract": "Objective: To develop and validate a clinical risk score predictive of risk for colorectal advanced neoplasia for Asia. Methods: A prospective, cross-sectional and multicentre study was carried out in tertiary hospitals in 11 Asian cities. The subjects comprise 2752 asymptomatic patients undergoing screening colonoscopy. From a development set of 860 asymptomatic subjects undergoing screening colonoscopy, multiple logistic regression was applied to identify significant risk factors for advanced colorectal neoplasia defined as invasive carcinoma or advanced adenoma. The ORs for significant risk factors were utilised to develop a risk score ranging from 0 to 7 (Asia-Pacific Colorectal Screening (APCS) score). Three tiers of risk were arbitrarily defined: 0-1 'average risk' (AR); 2-3 'moderate risk' (MR); and 4-7 'high risk' (HR). Subjects undergoing screening colonoscopy between July 2006 and December 2007 were prospectively enrolled to form an independent validation group. Each subject had a personal APCS score calculated by summing the points attributed from the presence of risk factors in the individuals. The performance of the APCS score in predicting risk of advanced neoplasia was evaluated. Results: There were 860 subjects in the derivation set and 1892 subjects in the validation set, with a baseline prevalence of advanced neoplasia of 4.5% and 3%, respectively. Applying the APCS stratification in the validation set, 559 subjects (29.5%) were in the AR tier, 966 subjects (51.1%) in the MR tier and 367 (19.4%) subjects in the HR tier. The prevalence of advanced neoplasia in the AR, MR and HR groups was 1.3, 3.2 and 5.2%, respectively. The subjects in the MR and HR tiers had 2.6-fold (95% CI 1.1 to 6.0) and 4.3-fold (95% CI 1.8 to 10.3) increased prevalence of advanced neoplasia, respectively, than those in the AR tier. Conclusions: The APCS score based on age, gender, family history and smoking is useful in selecting asymptomatic Asian subjects for priority of colorectal screening.",
        "keywords": [
            ""
        ],
        "venue": "Gut",
        "year": 2011,
        "id": "cSkryyyk"
    },
    "n18zCIjr": {
        "authors": [
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bang-Ping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Wei-Wei Ma",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Factors affecting the preoperative pulmonary function test in patients with scoliosis: A retrospective evaluation of 108 cases",
        "abstract": "Objectives: To evaluate factors affecting the preoperative pulmonary function in patients with scoliosis. Methods: Preoperative pulmonary function texts (PFTs) were performed on 108 patients with spinal deformities, 17 males and 91 females, aged (15.2 \u00b1 5.36) (7 - 27), 70 being with idiopathic scoliosis (IS) and 38 with congenital scoliosis (CS). The parameters affecting the preoperative pulmonary function were analyzed. Results: The Cobb angle of scoliosis was negatively correlated with vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), forced expiratory flow between 25% to 75% of forced vital capacity (FEF25-75), maxima mid-expiratory flow (MMEF), and maximal ventilatory volume (MVV), and not correlated with minute ventilation (MV) and ratio of forced expiratory volume in one second to forced vital capacity (FEV1/FVC%). The impairment of lung functions was more severe in the CS patients than in the IS patients. The degrees of impairment of lung functions in the groups of the Cobb angle \u226590\u00b0, with the number of vertebrae involved \u22657, with the age of onset <10, and of cephalad location of the curve were more severe than those of the groups with different corresponding parameters. Conclusion: The deterioration of pulmonary function mainly depends upon the age of onset, Cobb angle, location of the apex vertebra and the number of involved vertebrae.",
        "keywords": [
            "Respiratory function tests",
            "Scoliosis"
        ],
        "venue": "National Medical Journal of China",
        "year": 2008,
        "id": "n18zCIjr"
    },
    "fw2jr7sd": {
        "authors": [
            {
                "name": "Min Wang",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Xin Wang",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Rui Tian",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Chengjian Shi",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Ming Shen",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Meng Xu",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Juan Han",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Niannian Luo",
                "org": "Department of Biliary-Pancreatic Surgery"
            },
            {
                "name": "Renyi Qin",
                "org": "Department of Biliary-Pancreatic Surgery"
            }
        ],
        "title": "A modified technique of end-to-end pancreaticojejunostomy with transpancreatic interlocking mattress sutures",
        "abstract": "Background Postoperative pancreatic fistula (POPF) represents the most important cause of morbidity after pancreaticoduodenectomy (PD) and contributes to prolonged hospitalization and increased mortality rates. This study presents a new technique, which involves end-to-end pancreaticojejunostomy with transpancreatic interlocking mattress sutures, and evaluates its safety and reliability. Methods From January 2011 to May 2012, 79 patients with periampullary malignancies underwent PD by using this modified technique, and the morbidity and mortality rates were calculated. Results In this study, all cases recovered well from PD. Four transpancreatic interlocking mattress sutures were performed in 79 patients. The median duration of surgery was 3.9 hr (range 3.1-6.8), and the median time to perform pancreaticojejunostomy was 15.3 min (range 9-24). Overall, morbidity occurred in 16 patients (22.3%), and the causes included upper gastrointestinal bleeding (n = 2), biliary fistula (n = 1), pulmonary infection (n = 1), delayed gastric emptying (n = 1), abdominal abscess (n = 1, caused by PF), wound infection (n = 3), arrhythmia or myocardial infarction (n = 3), urinary tract infection (n = 2), and POPF (n = 2, 2.53%). One patient had grade A POPF, one had grade B POPF, and none of them had grade C POPF. No death occurred during surgery. Conclusion The end-to-end pancreaticojejunostomy with transpancreatic interlocking mattress sutures is a simple, rapid, safe, and reliable technique with low POPF rate and low delayed massive hemorrhage rate. \u00a9 2013 Wiley Periodicals, Inc.",
        "keywords": [
            "end-to-end pancreaticojejunostomy",
            "pancreatic fistula",
            "periampullary malignant tumor",
            "transpancreatic interlocking mattress sutures"
        ],
        "venue": "Journal of Surgical Oncology",
        "year": 2013,
        "id": "fw2jr7sd"
    },
    "hUzJEOm2": {
        "authors": [
            {
                "name": "Huiming Lai",
                "org": "Key Laboratory of Drug Targeting"
            },
            {
                "name": "Feng Zhu",
                "org": "Key Laboratory of Drug Targeting"
            },
            {
                "name": "Wenmin Yuan",
                "org": "Key Laboratory of Drug Targeting"
            },
            {
                "name": "Na He",
                "org": "Key Laboratory of Drug Targeting"
            },
            {
                "name": "Zhirong Zhang",
                "org": "Key Laboratory of Drug Targeting"
            },
            {
                "name": "Xiaoning Zhang",
                "org": "School of Medicine"
            },
            {
                "name": "Qin He",
                "org": "Key Laboratory of Drug Targeting"
            }
        ],
        "title": "Development of multiple-unit colon-targeted drug delivery system by using alginate: in vitro and in vivo evaluation",
        "abstract": "Drug delivery systems to the colon are being actively investigated. However, it is difficult to ensure that an oral preparation disintegrates specifically in the human colon. In this study, a pH- and enzyme-controlled, colon-targeted tablets (PECCTT) was established by using outer pH-coated layer and inner alginate-coated compression layer. The influence of the amount of alginate and enteric coat thickness on drug release had been investigated and the formulation that contained 30% alginate in compression layer and 13% weight gain in pH-coated layer was proved to protect the drug release from stomach and small intestine, the lag time was 7.04\u00b10.17h, and 84.45\u00b11.3% of prednisone was released at 12h. The results of drug release behaviors and SEM study indicated that drug release mechanism of PECCTT was corrosion. Hybrid scanner combining SPECT and CT was employed to monitor ",
        "keywords": [
            "\u03b2-mannanase medium",
            "Alginate",
            "Colon targeting",
            "PH-coated",
            "SPECT/CT"
        ],
        "venue": "Drug Development and Industrial Pharmacy",
        "year": 2011,
        "id": "hUzJEOm2"
    },
    "1wJZLlRc": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": ""
            },
            {
                "name": "Xu Sun",
                "org": ""
            },
            {
                "name": "Jack C. Y. Cheng",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Weiguo Li",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Yang Yu",
                "org": ""
            }
        ],
        "title": "Bone mineral accrual in osteopenic and nonosteopenic girls with idiopathic scoliosis during bracing treatment",
        "abstract": "Study Design. A prospective longitudinal follow-up study. ObjectiveS. To assess the effect of standardized bracing treatment on bone mineral density (BMD) accumulation in girls with adolescent idiopathic scoliosis (AIS) and to analyze the possible influencing factors of BMD accumulation during bracing treatment. Summary of Background Data. The association between osteopenia and AIS has been reported in numerous studies. Although a very recent study argued that bracing did not appear to affect BMD accumulation, the impact of initial bone mineral status on the BMD accrual during the bracing treatment has not been analyzed before. Methods. Using a dual energy radiograph absorptiometer, BMD and BMC measurements were taken initially and with a follow-up after 1 year in the lumbar spine (L2-L4, LS) and femoral neck (FN) of the nondominant side on AIS girls who were treated with braces. Differences in bone mineral accrual in initially osteopenic and nonosteopenic AIS girls were analyzed. The BMD accumulation rates were correlated with maturity status at entry, the anthropometric data, and the duration of bracing. Results. Forty-nine patients with AIS were included. At entry, osteopenia was found in 16 and 14 girls at the site of LS and FN, respectively. After an average duration of 1.1 years brace treatment, more than 94% of AIS girls had a positive bone mineral accrual. The annual accumulation rates of LS-BMD and FN-BMD were 0.054 g/(cm\u2022yr) and 0.076 g/(cm\u2022yr) respectively, and both were similar initially in osteopenic and nonosteopenic patients. Neither the total nor the daily bracing time correlated significantly with the accumulation rates at either site. The annualaccumulation rate of LS-BMD was found to be inversely correlated with maturity at entry whereas positively correlated with changes in height and weight. Conclusion. It is concluded that nearly all of AIS girls had positive bone mineral accrual at LS and FN during over-1-year brace treatment. Brace treatment and the initial bone mineral status may not play important roles in the BMD accumulation. Growth potential of AIS patients is one of the key factors influencing bone mineral accrual during brace treatment. \u00a9 2008 Lippincott Williams & Wilkins.",
        "keywords": [
            "Bone mineral density",
            "Brace treatment",
            "Girl",
            "Idiopathic scoliosis",
            "Osteopenia"
        ],
        "venue": "Spine",
        "year": 2008,
        "id": "1wJZLlRc"
    },
    "dG7fCQGk": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Shoufeng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Adolescent thoracolumbar scoliosis secondary to ganglioneuroma: A two case report",
        "abstract": "STUDY DESIGN. Case report with review of literature. OBJECTIVE. To report 2 cases of adolescent thoracic scoliosis secondary to paraspinal ganglioneuroma. SUMMARY OF BACKGROUND DATA. There are many types of scoliosis caused by known etiological factors. However, to our knowledge, adolescent thoracic scoliosis caused by paraspinal ganglioneuroma is seldom reported. METHODS. Case report. RESULTS. The deformity of these 2 patients was well corrected, and the tumor mass of ganglioneuroma was resected intact. Minor loss of correction was recorded in the 2 patients at 6-month and 2.5-year follow-up, respectively. No recurrence of tumor was found. CONCLUSION. Combination of scoliosis correction and tumor mass resection was a successful treatment for this kind of clinicopathological entity. \u00a9 2007 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Adolescent thoracic scoliosis",
            "Correction",
            "Ganglioneuroma",
            "Tumor resection"
        ],
        "venue": "Spine",
        "year": 2007,
        "id": "dG7fCQGk"
    },
    "W45Rl9Zs": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Min Wang",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Xin Wang",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Rui Tian",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Chengjian Shi",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Meng Xu",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Ming Shen",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Juan Han",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Ninanian Luo",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            },
            {
                "name": "Renyi Qin",
                "org": "Department of Biliary-Pancreatic Surgery, Affiliated Tongji Hospital, Tongji Medical College"
            }
        ],
        "title": "Modified Technique of Pancreaticogastrostomy for Soft Pancreas with Two Continuous Hemstitch Sutures: A Single-Center Prospective Study",
        "abstract": "Postoperative pancreatic fistula (POPF) remains a persistent problem after pancreaticoduodenectomy (PD), especially in the presence of a soft, nonfibrotic pancreas. To reduce the risk of POPF, pancreaticogastrostomy (PG) is an optional reconstruction technique for surgeons after PD. This study presents a new technique of PG for a soft, nonfibrotic pancreas with double-binding continuous hemstitch sutures and evaluates its safety and reliability. From January 2011 to June 2012, 92 cases of patients with periampullary malignancy with a soft pancreas underwent this technique. A modified technique of PG was performed with two continuous hemstitch sutures placed in the mucosal and seromuscular layers of the posterior gastric wall, respectively. Then the morbidity and mortality was calculated. This technique was applied in 92 patients after PD all with soft pancreas. The median time for the anastomosis was 12 min (range, 8-24). Operative mortality was zero, and morbidity was 16.3 % (n = 15), including hemorrhage (n = 2), biliary fistula (n = 2), pulmonary infection (n = 1), delayed gastric emptying (DGE; n = 5, 5.4 %), abdominal abscess (n = 3, one caused by PF), and POPF (n = 2, 2.2 %). Two patients developed a pancreatic fistula (one type A and one type B) classified according to the International Study Group on Pancreatic Fistula. The described technique is a simple and safe reconstruction procedure after PD, especially for patients with a soft and fragile pancreas. \u00a9 2013 The Author(s).",
        "keywords": [
            "Continuous hemstitch sutures",
            "Pancreaticoduodenectomy",
            "Pancreaticogastrostomy",
            "Periampullary carcinoma",
            "Postoperative pancreatic fistula"
        ],
        "venue": "Journal of Gastrointestinal Surgery",
        "year": 2013,
        "id": "W45Rl9Zs"
    },
    "fvdK6amC": {
        "authors": [
            {
                "name": "Jun Qiao",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Leilei Xu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Comparison of the aorta impingement risks between thoracolumbar/lumbar curves with different convexities in adolescent idiopathic scoliosis: A computed tomography study",
        "abstract": "Purpose To compare the positions of the aorta relative to vertebral bodies and the potential risk of the aorta impingement for pedicle screw (PS) placement between right-sided and left-sided thoracolumbar/lumbar curves of adolescent idiopathic scoliosis (AIS). Methods Thirty-nine AIS patients with a main thoracolumbar or lumbar curve were recruited. The Lenke's classification was type 5C in all patients. According to the convexity of the thoracolumbar or lumbar curves, the patients were divided into either group R or Group L. The patients in Group R had a main right-sided thoracolumbar/ lumbar curve, and the patients in Group L had a main left-sided thoracolumbar/lumbar curve. Axial CT images from T12 to L4 at the midvertebral body level were obtained to evaluate Aorta-vertebra angle (\u03b1), Vertebral rotation angle (\u03b2), Lefty safety distance (LSD), and Right safety distance (RSD). The risks of the aorta impingement from T12 to L4 were calculated and then compared between the two groups. Results The \u03b1 increased from T12 through L4 in Group R, increased from T12 through L1, and then decreased from L1 through L4 in Group L. The b decreased from T12 through L4 in both groups. The LSD constantly increased from T12 through L4 in Group R, increased from T12 through L3, and then decreased from L3 through L4 in Group L. The RSD increased from T12 through L3 and then decreased from L3 through L4 in both groups. With the increment of the lengths of the simulated screws, the aorta impingement risks were constantly elevated at all levels in both groups. The aorta was at a high risk of impingement from left PS regardless of the diameters of the simulated screws in Group R (80-100 % at T12 and 53.3-100 % at L1). In Group L, the aorta was completely safe when using 35 mm (0 at all levels) PS and at high risks of the aorta impingement on the right side from 45 mm PSs (31.8-72.7 %). In all, the risks of the aorta impingement were mainly from left PS in Group R and from right PS in Group L, and the risk of the aorta impingement from PS placement was generally higher in right thoracolumbar or lumbar curves when compared with that of the left. Conclusions The present study illustrated different changed positions of the aorta relative to vertebrae between thoracolumbar/lumbar curves with different convexities. In right-sided curve, the risks of the aorta impingement were mainly from left PS while in left-sided curves, from right PS. The aorta was more proximal to entry points in rightsided lumbar curve when compared with left-sided curve; thus placing PS carries more risks in right-sided thoracolumbar/ lumbar curve. Surgeons should be more cautious when placing PSs on the concave sides of T12 and L1 vertebrae of right-sided thoracolumbar/lumbar curves. \u00a9 Springer-Verlag 2012.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Aorta impingement",
            "Convexity",
            "Thoracolumbar/lumbar curve"
        ],
        "venue": "European Spine Journal",
        "year": 2012,
        "id": "fvdK6amC"
    },
    "UqszXfRp": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Winnie Chiu-Wing Chu",
                "org": ""
            },
            {
                "name": "Guangquan Sun",
                "org": ""
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": ""
            },
            {
                "name": "Wei-Jun Wang",
                "org": ""
            },
            {
                "name": "Jack C.Y. Cheng",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Rib length asymmetry in thoracic adolescent idiopathic scoliosis: Is it primary or secondary?",
        "abstract": "The development of scoliosis in animal models after inducing asymmetric rib growth suggests the possible role of asymmetric rib growth in the etiopathogenesis of adolescent idiopathic scoliosis (AIS). Asymmetric rib length is well recognized in idiopathic scoliosis; however, whether this rib asymmetry is primary or secondary has not been clearly documented. The objectives of this study were to investigate any rib length asymmetry in patients with AIS and compare those with scoliosis with syringomyelia (SS) with the intention of elucidating any relationship between rib growth and pathogenesis of AIS. Forty-eight AIS and 29 SS with apical vertebrae located between T7 and T9 were recruited. The average age was 13.5 \u00b1 2.3 versus 12.5 \u00b1 3.4 years, and the average Cobb angle of thoracic curve was 43.3\u00b0 \u00b1 16.4\u00b0 versus 45.6\u00b0 \u00b1 22.6\u00b0 in patients with AIS or SS, respectively. The length of all ribs was measured from the tip of costal head to the end of the same rib by built-in software on spiral computed tomography. At the levels of the apical vertebrae, the vertebrae above and below the apex, the mean discrepancy in rib length (concave minus convex rib) was 7, 4 and 7 mm, respectively, in AIS group (p < 0.01), and 6, 5 and 7 mm in SS group, respectively (p < 0.01). The rib length discrepancy between concave and convex sides was significantly correlated with the magnitude of the Cobb angle of thoracic curve in both AIS and SS groups (p < 0.01). Similar findings of the asymmetry of rib length in both AIS and SS patients pointed strongly to the fact that the rib length asymmetry in apical region is most likely secondary to the scoliosis deformity rather than playing a primary role in the etiopathogenesis. \u00a9 Springer-Verlag 2010.",
        "keywords": [
            "Asymmetry",
            "Idiopathic scoliosis",
            "Rib length"
        ],
        "venue": "European Spine Journal",
        "year": 2011,
        "id": "UqszXfRp"
    },
    "SjIbVX9U": {
        "authors": [
            {
                "name": "Yun-Fei Duan",
                "org": "Department of Hepatobiliary Surgery, Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Xiao-Dong Li",
                "org": "Department of Oncology, Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Dong-Lin Sun",
                "org": "Department of Hepatobiliary Surgery, Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Xue-Min Chen",
                "org": "Department of Hepatobiliary Surgery, Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Yong An",
                "org": "Department of Hepatobiliary Surgery, Third Affiliated Hospital of Soochow University"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Hepatobiliary Surgery, Third Affiliated Hospital of Soochow University"
            }
        ],
        "title": "A preliminary study on surgery for hepatocellular carcinoma patients with portal hypertension",
        "abstract": "Background To assess the effects of various operations for hepatocellular carcinoma with portal hypertension (PH). Methods Data regarding 78 patients with resectable liver cancer with PH were analyzed. Patients were divided into 3 groups: A (splenic artery ligation), B (in situ splenectomy), and C (in situ splenectomy + pericardial devascularization). Results White blood cell and platelet counts in the 3 groups increased significantly after surgery. Postoperative portal pressure was not significantly lower than preoperative portal pressure in Group A, while it was significantly lower in B. In Group C, the portal pressure after splenectomy was significantly lower than that before the operation, but not again after pericardial devascularization. The 1-, 2-, and 3-year survival rates of all the patients were 89.7%, 64.1%, and 46.1%, respectively. Conclusions PH is not an absolute contraindication to liver resection in Child-Pugh class B cirrhotic patients. The combined surgery for hepatocellular carcinoma patients with PH is a safe choice.",
        "keywords": [
            "Cirrhosis",
            "Hepatocellular carcinoma",
            "Portal hypertension",
            "Surgery"
        ],
        "venue": "American Journal of Surgery",
        "year": 2015,
        "id": "SjIbVX9U"
    },
    "6Gi884Yy": {
        "authors": [
            {
                "name": "Weijun Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Xin Zhen",
                "org": "Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "T.P. Lam",
                "org": "Department of Orthopaedics and Traumatology"
            },
            {
                "name": "Jack C.Y. Cheng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Yong Qiu",
                "org": "Joint Scoliosis Research Center"
            }
        ],
        "title": "The value of different Risser grading systems in determining growth maturity of girls with adolescent idiopathic scoliosis",
        "abstract": "A grading system for ossification of the iliac apophysis (Risser sign) was developed for skeletal maturity assessment in the United States (US) then adopted with modifications in France (Fr) and other countries. Despite the same name, these systems have important differences. With the aim to analyzing the difference between US and Fr Risser grading systems in determining the growth maturity of girls with adolescent idiopathic scoliosis (AIS), Fifty-three AIS girls undergoing posterior spinal correction with autogenous bone graft were recruited. The Risser grades were recorded for the non-dominant side iliac crest apophysis according to the US and Fr grading systems. Growth activity was determined by standard histologic grades (HGs) on iliac crest cartilage. As a result, Kappa statistics showed poor agreement between two grading systems. The US system showed higher correlation with HGs compared to Fr system by Spearman correlation analysis. It was also found that growth cessation could be determined by Risser grade 5 of US system or Risser grade 4 of Fr system. Furthermore, by employing Receiver Operating Characteristic (ROC) curve analysis, it was found that the Risser grade 4-5 of US system with two years after menarche could be used in determining growth cessation with the highest sensitivity, specificity and accuracy. Hence it was concluded that the US Risser grading system was better in determining maturity of girls with AIS than Fr Risser grading system. By combining years since menarche, the accuracy of Risser grades in determining growth cessation could be enhanced, and the time of weaning from a brace could be advanced. \u00a9 2012 The authors and IOS Press. All rights reserved.",
        "keywords": [
            "Adolescent",
            "Growth potential",
            "Histology",
            "Risser grades",
            "Scoliosis"
        ],
        "venue": "Studies in Health Technology and Informatics",
        "year": 2012,
        "id": "6Gi884Yy"
    },
    "FNBIjw8M": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Wei-Jun Wang",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Bin Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bobby Kin Wah Ng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Jack Chun Yiu Cheng",
                "org": "Joint Scoliosis Research Center"
            }
        ],
        "title": "Accuracy of thoracic vertebral screw insertion in adolescent idiopathic scoliosis: A comparison between thoracoscopic and mini-open thoracotomy approaches",
        "abstract": "STUDY DESIGN.: A cross-sectional study with axial computed tomography (CT) to compare the accuracy of vertebral screw insertion in the thoracic spine for adolescent idiopathic scoliosis (AIS) between the thoracoscopic and the mini-open thoracotomy approach. OBJECTIVE.: To evaluate the safety of vertebral screw placement in anterior instrumentation for thoracic AIS. SUMMARY OF BACKGROUND DATA.: Thoracoscopic anterior instrumentation has been used with good results for AIS. It is technically demanding especially for the insertion of vertebral screws. The important issue of whether the screws inserted thoracoscopically is as accurate and safe as those inserted through thoracotomy approach has not been well studied. METHODS.: Thirty-one patients with thoracic AIS receiving thoracoscopic or mini-open thoracotomy anterior instrumentation were included in this study. They were divided into Group A and B, respectively. Postoperative sequential CT scanning on the thoracic vertebral screws was carried out. The relative position between screws and the spinal canal, the aorta, and the bicortical purchase were analyzed with CT images. The percentage of screws in good position was defined and further analyzed. RESULTS.: Seventy-three and 162 thoracic vertebral screws were inserted in 10 patients in Group A and 21 patients in Group B, respectively. Eighty-nine percent of screw tips in Group A and 80.2% in Group B were distant from the aorta, 89.0% and 87.0% of screws achieved bicortical purchase in Group A and B, respectively. No significant difference was found in all thoracic levels including the upper thoracic, periapical, or lower thoracic vertebrae. Seventy-four percent and 66.7% of screws were in good positions in Group A and B, respectively and there was no statistically significant difference between the 2 groups. CONCLUSION.: The vertebral screws inserted through thoracoscopic approach were as accurate as those inserted through a mini-open thoracotomy approach. The accuracy could be enhanced by using screws with smaller increments, with special attention to the possible migration of aorta with anterior spinal instrumentation. \u00a9 2008 Lippincott Williams & Wilkins.",
        "keywords": [
            "Aorta",
            "Scoliosis",
            "Spinal canal",
            "Thoracoscopy",
            "Vertebral screw"
        ],
        "venue": "Spine",
        "year": 2008,
        "id": "FNBIjw8M"
    },
    "BBy62aWu": {
        "authors": [
            {
                "name": "Hui Peng",
                "org": "Shanghai Jiaotong Univ."
            },
            {
                "name": "Yan Zhang",
                "org": "Shanghai Jiaotong Univ."
            },
            {
                "name": "Yan-Kui Zhang",
                "org": "Shanghai Jiaotong Univ."
            },
            {
                "name": "Yong Zhang",
                "org": "East China Elec. Power Group Corp."
            },
            {
                "name": "Feng Zhu",
                "org": "East China Elec. Power Group Corp."
            }
        ],
        "title": "Research on the optimized planned-maintenance period of turbo-generator",
        "abstract": "The equivalent aging model of turbo-generators is established based on the analysis of the relation between the maintenance and the life of turbo-generators. Then, an optimum mathematic model of planned-maintenance period is established based on reliability and cost-benefit analysis to optimize the economic benefit of turbo-generators long-term operation. The Monte Carlo simulation is used to simulate the process of failure and to calculate the optimized planned-maintenance period. Some meaningful conclusions are obtained by the application of the method to a domestic power plant. The result of the research can be used as the foundation for decision-making of turbo-generators planned maintenance.",
        "keywords": [
            "Maintenance period",
            "Monte Carlo simulation",
            "Turbo-generator"
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2003,
        "id": "BBy62aWu"
    },
    "EjIX2GIc": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Burn Center"
            },
            {
                "name": "Zhao-Fan Xia",
                "org": "Burn Center"
            }
        ],
        "title": "Paracrine activity of stem cells in therapy for acute lung injury and adult respiratory distress syndrome",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Journal of Trauma and Acute Care Surgery",
        "year": 2013,
        "id": "EjIX2GIc"
    },
    "njZIarhg": {
        "authors": [
            {
                "name": "Zhen-Guo Zeng",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Fen Liu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Jiang Rong",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Feng Zhu",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Cheng Nie",
                "org": "Intensive Care Unit"
            },
            {
                "name": "Ke-Jian Qian",
                "org": "Intensive Care Unit"
            }
        ],
        "title": "Effect of high volume hemofiltration on pulmonary surfactant protein in endotoxin induced acute lung injury in dog",
        "abstract": "Objective: To explore the effect of high volume hemofiltration (HVHF) on pulmonary surfactant protein (SP) in endotoxin induced acute lung injury (ALI) in dogs. Methods: Sixteen healthy male mongrel dogs were given lipopolysaccharide (LPS 650 \u03bcg/kg) via central vein within 30 minutes. After the reproduction of the model, they were divided into two groups randomly (n = 8). One group received the treatment of HVHF and mechanical ventilation (MV, treatment group), while another received only MV (model group). Parameters of arterial blood gas and respiratory mechanics were recorded at basic values, after reproduction of the experimental model, and 1, 2 and 4 hours after HVHF. Content of SP - B in lung tissue homogenate was measured by protein Western blot. Results: After injection of LPS, partial pressure of oxygen in artery (PaO",
        "keywords": [
            "Acute lung injury",
            "Endotoxin",
            "High volume hemofiltration",
            "Pulmonary surfactant protein"
        ],
        "venue": "Chinese Critical Care Medicine",
        "year": 2006,
        "id": "njZIarhg"
    },
    "MpIp42IO": {
        "authors": [
            {
                "name": "Fei Chen",
                "org": "Department of Neurology"
            },
            {
                "name": "Xin Zhang",
                "org": "Department of Radiology"
            },
            {
                "name": "Ming Li",
                "org": "Department of Radiology"
            },
            {
                "name": "Rong Wang",
                "org": "Department of Neurosurgery and Spinal Surgery"
            },
            {
                "name": "Hui-Ting Wang",
                "org": "Nanjing Wei-sheng School"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Neurosurgery and Spinal Surgery"
            },
            {
                "name": "De-Ji Lu",
                "org": "Medical Electronics Laboratory"
            },
            {
                "name": "Hui Zhao",
                "org": "Department of Neurology"
            },
            {
                "name": "Jing-Wei Li",
                "org": "Department of Neurology"
            },
            {
                "name": "Yun Xu",
                "org": "Department of Neurology"
            },
            {
                "name": "Bin Zhu",
                "org": "Department of Radiology"
            },
            {
                "name": "Bing Zhang",
                "org": "Department of Radiology"
            }
        ],
        "title": "Axial diffusivity and tensor shape as early markers to assess cerebral white matter damage caused by brain tumors using quantitative diffusion tensor tractography",
        "abstract": "Aims: We investigated the usefulness of diffusion tensor tractography (DTT) for differentiating between histological pathologies and evaluating white matter (WM) damage resulting from brain tumors. We also sought to categorize the appearance of brain tumor-related WM tract changes. Methods: A total of 18 inpatients with intracranial neoplasms were enrolled. MRI examinations were performed at 3 T using an 8-channel phased array coil. DTT was reconstruction from the raw data of diffusion tensor imaging. WM tract-based analysis of the mean diffusivity (MD), eigenvalues (\u03bb",
        "keywords": [
            "Axial diffusivity",
            "Brain tumor",
            "Diffusion tensor tractography",
            "Eigenvalue",
            "Tensor shape",
            "White matter damage"
        ],
        "venue": "CNS Neuroscience and Therapeutics",
        "year": 2012,
        "id": "MpIp42IO"
    },
    "tXq8yPoi": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Rong-Rong Nie",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Ling Wu",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Lei Liu",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Wei Tang",
                "org": "State Key Laboratory of Oral Diseases"
            },
            {
                "name": "Wei-Dong Tian",
                "org": "State Key Laboratory of Oral Diseases"
            }
        ],
        "title": "Expression of odontogenic and osteogenic genes in bone marrow mesenchymal stem cells with overexpression of mouse dentin sialophosphoprotein",
        "abstract": "Objective To observe the overexpression of dentin sialophosphoprotein (DSPP) in mouse bone marrow mesenchymal stem cells (BM-MSC) and the expression of specific gene involved in odontogenic and osteogenic differentiation in transfected cells. Methods Mouse bone marrow mesenchymal stem cells (BM-MSC) were cultured and then transfected with DSPP gene by adenovirus-mediated way in vitro. The transfection efficiency of DSPP gene was assessed by the marker gene green fluorescent protein (GFP). With having observed the morphological transformation of transfected BM-MSC, we studied whether the transfected BM-MSC would express odontogenic and osteogenic genes by RT-PCR. Results The mouse BM-MSC were obtained and the adenovirus mediated DSPP gene used to transfect BM-MSC successfully. The transfected efficiency was 42. 7%. The transfected BM-MSC were induced to differentiate into odontoblast-like cells and meanwhile expressed specific odontogenic and osteogenic differentiation genes such as DSPP, DMP1, Msx1/2, Pax9, Lhx6/7, Sox9, Cbfa1, Osx, Col I. Conclusion The bone marrow mesenchymal stern cells can make differentiation with the overexpression of dentin sialophosphoprotein and express specific odontogenic and osteogenic differentiation genes.",
        "keywords": [
            "Adenovirus odontogenic differentiation",
            "Bone marrow mesenchymal stem cells",
            "Dentin sialophosphoprotein"
        ],
        "venue": "Journal of Sichuan University (Medical Science Edition)",
        "year": 2008,
        "id": "tXq8yPoi"
    },
    "MNUsbzgq": {
        "authors": [
            {
                "name": "Zhi-Fa Zhang",
                "org": "Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Ren-Yi Qin",
                "org": "Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Min Wang",
                "org": "Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Xu Li",
                "org": "Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Cheng-Jian Shi",
                "org": "Department of Biliary and Pancreatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology"
            }
        ],
        "title": "TGF-\u03b21-induced epithelialmesenchymal transition increases the abundance of side population cells in human gallbladder cancer cell line GBC-SD",
        "abstract": "AIM: To investigate the impact of transforming growth factor-\u03b21 (TGF-\u03b21)-induced epithelialmesenchymal transition (EMT) on side population cells in human gallbladder cancer cell line GBC-SD. METHODS: GBC-SD cells were allowed to adhere and then incubated with human recombinant TGF-\u03b21 to induce EMT in vitro. Morphological alterations were examined by phasecontrast microscopy, and the expression of EMT-related proteins was detected by Western blot. The percentage of SP cells in GBC-SD cells with and without TGF-\u03b21 was analyzed by flow cytometry. After the removal of TGF-\u03b21, cellular morphological alterations, the expression of EMT-related proteins, and the percentage of SP cells were detected again. RESULTS: SP cells accounted for approximately 0.87% of GBC-SD cells. TGF-\u03b21 induced morphological transition from epithelial to mesenchymal cells. After treatment with TGF-\u03b21, the expression of epithelial cell marker E-cadherin was decreased, that of mesenchymal cell marker vimentin was increased, and the percentage of SP cells was increased to 2.3%. After removal of TGF-\u03b21, transitioned GBC-SD cells regained the epithelial phenotypes and restored the SP abundance. CONCLUSION: TGF-\u03b21-induced reversible EMT increases the percentage of SD cells in human gallbladder cancer cell line GBC-SD, suggesting that EMT may promote tumor progression by augmenting the abundance of SP cells.",
        "keywords": [
            "Epithelial-mesenchymal transition",
            "Human gallbladder cancer",
            "Side population cells",
            "Transforming growth factor-\u03b21"
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2011,
        "id": "MNUsbzgq"
    },
    "5cu13gFG": {
        "authors": [
            {
                "name": "Yanxiang Sun",
                "org": "Zhongshan Hospital"
            },
            {
                "name": "Feng Zhu",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Min Wang",
                "org": "Laboratory of Cardiovascular Immunology"
            },
            {
                "name": "Shihui Ma",
                "org": "Zhongshan Hospital"
            },
            {
                "name": "Yuhua Liao",
                "org": "Laboratory of Cardiovascular Immunology"
            }
        ],
        "title": "Association analysis about HLA-DRB1, -DQB1 polymorphism and auto-antibodies against \u03b11-adrenergic receptors in Chinese patients with essential hypertension",
        "abstract": "The auto-antibodies against \u03b1",
        "keywords": [
            "auto-antibody",
            "HLA-DQB1",
            "HLA-DRB1",
            "hypertension",
            "polymorphism"
        ],
        "venue": "Clinical and Experimental Hypertension",
        "year": 2010,
        "id": "5cu13gFG"
    },
    "2J7KCwv4": {
        "authors": [
            {
                "name": "Jin Zhou",
                "org": "Department of Neurology"
            },
            {
                "name": "Guo-Ping Tian",
                "org": "Department of Neurology"
            },
            {
                "name": "Li-Hua Wu",
                "org": "Department of Neurology"
            },
            {
                "name": "Chun-Yan Zhu",
                "org": "Department of Neurology"
            },
            {
                "name": "Jing-E. Wang",
                "org": "Department of Neurology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Neurology"
            },
            {
                "name": "Feng-Jie Hu",
                "org": "Department of Neurology"
            }
        ],
        "title": "Capability and feasibility of human adipose tissue derived stromal cells differentiating into neuron-like cells",
        "abstract": "Aim: It is reported that adipose tissue derived stromal cells can differentiate into neuron-like cells and express neuron signal. The study aimed to explore the feasibility of inducing the differentiation of human adipose tissue derived stromal cells into neuron-like cells in vitro. Methods: Experiments were performed at the Experimental Center of Shenyang Brain Hospital from September 2003 to June 2005. Abdominal fat was provided by Department of General Surgery of Shenyang First Hospital. Patients signed informed constents. Experimental procedures were approved by Hospital Ethics Committee. Human adipose tissue derived stromal cells were isolated, cultured and proliferated in vitro, then identified by immunofluorescent staining for CD44, CD114, CD34. Second and third generations cells were incubated with culture medium containing butylated hydroxyani sole, KCL, valproic acid, desamethasone and insulin after washing with PBS, and induced differentiating into neural cells. Neuro-specific enolase was identified by immsunofluorescent staining. Results: Primarily cultured adipose tissue derived stromal cells were fusiform, scattered and fused about 7 days later. 96.7% cells were positive for CD44, and negative for CD114 antibody and CD34 antibody under fluorescent invert microscope. Neuro-specific enolase immunofluorescence showed that adipose tissue derived stromal cells appeared axis-cylinder and dendrite-like structure, and differentiate into neuron-like cells. Conclusion: Human adipose tissue derived stromal cells can amplify in vitro, and differentiate into neuron-like cells under a certain condition.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Clinical Rehabilitative Tissue Engineering Research",
        "year": 2008,
        "id": "2J7KCwv4"
    },
    "hQhySGOA": {
        "authors": [
            {
                "name": "Cai-Wei Xia",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu-Sheng Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Shou-Feng Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Vitamin D receptor gene polymorphisms in female adolescent idiopathic scoliosis patients",
        "abstract": "Objective: To investigate the association of vitamin D receptor (VDR) gene polymorphisms with abnormal growth pattern and low bone mass in adolescent idiopathic scoliosis (AIS) patients. Methods: Peripheral blood samples were obtained from 164 female patients with AIS, aged 14.4 \u00b1 2 (9-20), and 122 age-matched healthy girls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect the VDR gene distributions. Results: The frequency of Bb genotype was significantly higher in the AIS patients than in the controls (P < 0.01). The frequency of B alleles of the AIS patients was significantly higher than that of the controls (P < 0.01). In AIS patients, the expression rate of Aa genotype of the AIS patients with the body mass index (BMI) \u226518 kg/m",
        "keywords": [
            "Genotype",
            "Receptor, calcitriol",
            "Scoliosis"
        ],
        "venue": "National Medical Journal of China",
        "year": 2007,
        "id": "hQhySGOA"
    },
    "jDTTrDN2": {
        "authors": [
            {
                "name": "Jun Qiao",
                "org": "Medical School"
            },
            {
                "name": "Zhen Liu",
                "org": "Medical School"
            },
            {
                "name": "Leilei Xu",
                "org": "Medical School"
            },
            {
                "name": "Tao Wu",
                "org": "Medical School"
            },
            {
                "name": "Xin Zheng",
                "org": "Medical School"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Medical School"
            },
            {
                "name": "Bangpin Qian",
                "org": "Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Medical School"
            }
        ],
        "title": "Reliability analysis of a smartphone-aided measurement method for the cobb angle of scoliosis",
        "abstract": "Study Design: A comparison between the smartphone-aided measurement method and the manual measurement method for the Cobb angle in adolescent idiopathic scoliosis. Objective: To evaluate the reliability and measurement error for the smartphone-aided Cobb angle measurement method and compare its reliability and measurement error with those of the manual method. Summary of Background Data: The development of smartphones has provided new opportunities that integrate mobile technology into daily clinical practice. Smartphone applications can provide quick assistance in the diagnosis and treatment of disease. Cobbmeter is a smartphone application designed for the measurement of Cobb angle on Apple iPhone smartphones. There is no study on the reliability and measurement error of this smartphone-aided measurement method. Methods: Fifty-three posteroanterior radiographs of adolescent idiopathic scoliosis patients with thoracic scoliosis were used for the standard Cobb method of measurement (manual set) and the smartphone-aided Cobb method of measurement (smartphone set). Five spinal surgeons measured the Cobb angle with the use of both the manual method and the smartphone-aided method. The measurement time was recorded for every measurement. The frequency and the cumulative percent distribution for intraobserver differences were tabulated, both for the individual examiners and for the overall results for the 5 examiners. The intraclass correlation coefficient (ICC) 2-way mixed model on absolute agreement was used to analyze measurement reliability. Summary statistics from analyses of variance calculations were used to provide 95% prediction limits for the error in measurements. A paired t test was used to compare the time consumed for the measurement between both sets. Results: The intraobserver and interobserver ICCs were excellent in the smartphone set and in the manual set. Both the intraobserver ICC and the interobserver ICC were better in the smartphone set than in the manual set. The mean Cobb angle of all measured x-rays was 29.3 degrees (range, 17-58 degrees) in the manual set and 29.1 degrees (range, 18-56 degrees) in the smartphone set. The mean time consumed was 13.7 seconds (range, 8.6-18.5 s) for the smartphone set, whereas it was 37.9 seconds (range, 30.1-46.9 s) for the manual set, and the mean time consumed for the smartphone set was significantly shorter than that of the manual set (P<0.05). Conclusions: Smartphone-aided measurement for Cobb angle showed excellent reliability and efficiency. It is suggested to popularize the use of this method in clinical practice. Copyright \u00a9 2012 by Lippincott Williams & Wilkins.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "manual measurement",
            "reliability",
            "smartphone-aided measurement"
        ],
        "venue": "Journal of Spinal Disorders and Techniques",
        "year": 2012,
        "id": "jDTTrDN2"
    },
    "quD8yK7d": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medicine, Nanchang University"
            },
            {
                "name": "Nengchu Zeng",
                "org": "Department of Critical Care Medicine, Nanchang University"
            },
            {
                "name": "Yuanli Luo",
                "org": "Department of Critical Care Medicine, Nanchang University"
            },
            {
                "name": "Hede Feng",
                "org": "Department of Critical Care Medicine, Nanchang University"
            },
            {
                "name": "Xincheng Liao",
                "org": "Department of Critical Care Medicine, Nanchang University"
            },
            {
                "name": "Mingzhuo Liu",
                "org": "Department of Critical Care Medicine, Nanchang University"
            },
            {
                "name": "Guanghua Guo",
                "org": "Department of Critical Care Medicine, Nanchang University"
            }
        ],
        "title": "Effects of different position during high frequency oscillatory ventilation on oxygenation and hemodynamics of dogs with severe smoke inhalation injury",
        "abstract": "Objective: To study the effects of high frequency oscillatory ventilation (HFOV) with different position on oxygenation and hemodynamics of dogs with severe smoke inhalation injury. Methods: After being treated with conventional mechanical ventilation, 12 dogs were inflicted with severe smoke inhalation injury and treated by HFOV for 30 min. They were divided into HFOV + prone positioning (PP) group and HFOV + supine positioning (SP) group according to the random number table, with 6 dogs in each group. They received HFOV with corresponding position for 8 hours respectively. Results of blood gas analysis (pH, PaO",
        "keywords": [
            "Burns, inhalation",
            "Hemodynamics",
            "High-frequency ventilation",
            "Oxygenation",
            "Prone position"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2014,
        "id": "quD8yK7d"
    },
    "lvafMxoN": {
        "authors": [
            {
                "name": "Tao Wu",
                "org": "Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Xin Zheng",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Jack C.Y. Cheng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Yong Qiu",
                "org": "Joint Scoliosis Research Center"
            }
        ],
        "title": "Role of high central leptin activity in a scoliosis model created in bipedal amputated mice",
        "abstract": "Significantly lower circulating leptin level has been reported in adolescent idiopathic scoliosis (AIS) compared to healthy adolescents. It was hypothesized that leptin dysfunction might be involved in the etiopathogenesis of AIS. In this study, a scoliosis model of bipedal amputated mice with high central leptin activity was established to validate this hypothesis. Three days after bipedal amputation, the mice were randomly divided into two groups: then 8 mice were injected in the hypothalamus with lentivirus vectors which expressed leptin, whereas the remaining 8 were injected with lentivirus vectors expressing GFP (control vector). X-rays were obtained at 20th week to determine the development of spinal deformity. After that all mice were sacrificed, and blood samples were collected. Then peripheral leptin levels were measured by an ELISA kit. Comparisons for the incidence of scoliosis and the severity of the curves were performed between groups. The body weight was found to be slightly lower in the leptin-vector-treated C3H/HeJ mice when compared with control mice. Significantly higher peripheral serum leptin level was found in leptin-vectortreated mice than control mice. Scoliosis was observed in all leptin-vector-treated mice with an average Cobb angle of 28.2\u00b0, and in 4/8 of control with an average Cobb angle of 23.5\u00b0. The incidence of scoliosis was significantly higher in leptinvector- treated mice than in control group, although no significant difference was found in terms of curve severity. The results of this study indicated that the high central leptin activity might not only increase the risk of developing a scoliosis in bipedal mice but also contribute to the progression of scoliosis. The high central leptin activity might play an important role in the etiopathogenesis of scoliosis. \u00a9 2012 The authors and IOS Press. All rights reserved.",
        "keywords": [
            "Bipedal amputated mice",
            "Dysfunction",
            "Leptin",
            "Scoliosis"
        ],
        "venue": "Studies in Health Technology and Informatics",
        "year": 2012,
        "id": "lvafMxoN"
    },
    "kwxqMi3Y": {
        "authors": [
            {
                "name": "Song Zhou",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Weijun Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Gang Yin",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Increased expression of receptor activator of nuclear factor-\u03baB ligand in osteoblasts from adolescent idiopathic scoliosis patients with low bone mineral density",
        "abstract": "Persistent generalized low bone mineral density (BMD) has been reported in patients with adolescent idiopathic scoliosis (AIS). However, the exact mechanisms and causes of the low BMD in AIS patients are largely unknown. The purpose of this study was to examine the relationship between the receptor activator of NF-\u03baB ligand (RANKL)/osteoprotegerin (OPG) levels in osteoblasts (OBs) from AIS patients with low BMD and with comparison made between the patients and controls. Twenty AIS patients and eight age-matched controls were included in the present study. The BMD of lumbar spine and proximal femur was measured in all subjects. OBs from the cancellous bone of each subject was harvested and primarily cultured. The mRNA and protein expression of RANKL and OPG in OBs was detected by RT-PCR and Western blotting. The results showed BMD was lower in AIS patients than in controls. A significantly higher mRNA and protein expression of RANKL was observed in OBs from AIS patients, while no significant difference was found in the expression of OPG between AIS patients and controls. As a result, RANKL/OPG ratio in patients with AIS was remarkably higher than controls. Our study preliminarily demonstrated expression of RANKL was higher in OBs from AIS patients with low BMD as compared with controls, suggesting the unbalanced RANKL/OPG ratio caused by an over-expression of RANKL in OBs may be responsible for the low BMD in AIS patients. \u00a9 Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2012.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Bone mineral density",
            "Osteoblast",
            "Osteoprotegerin",
            "Receptor activator of NF-\u03baB ligand"
        ],
        "venue": "Journal of Huazhong University of Science and Technology - Medical Science",
        "year": 2012,
        "id": "kwxqMi3Y"
    },
    "I1eeXtZY": {
        "authors": [
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Abnormal spreading and subunit expression of junctional acetylcholine receptors of paraspinal muscles in scoliosis associated with syringomyelia",
        "abstract": "STUDY DESIGN. A comparative study was performed among 2 groups of patients: Group A with scoliosis and syringomyelia and Group B with idiopathic scoliosis. OBJECTIVE. To investigate the denervation of paraspinal muscles and analyze its association with scoliosis in patients with syringomyelia. SUMMARY OF BACKGROUND DATA. The mechanism by which scoliosis develops secondary to syringomyelia remains unclear. Some authors hypothesize that scoliosis may be caused by an alteration in the innervation of the trunk musculature. Few studies, however, have been reported to testify the presence of denervation of the paraspinal muscles in scoliotic patients with syringomyelia. METHODS. Forty-one children were enrolled in the study and were divided into 2 groups. Group A consisted of 25 patients with scoliosis associated with syringomyelia. Group B included 16 adolescents with idiopathic scoliosis. Bilateral biopsy of paraspinal muscles was performed during scheduled spinal surgery. Distribution of acetylcholine receptors (AChRs) and acetylcholinesterase was investigated by immunofluorescence staining. RT-PCR was performed to determine the AChRs subunit mRNA expression. RESULTS. Immunostaining showed that 56% patients in Group A were scored positive for the loss of localization of AChRs to neuromuscular junction, while all Group B patients were negative. \u03b3-AChR subunit expression was detected in 65% patients in Group A while absent in all samples in Group B. There was no statistical significance of both the positive rate of abnormal spreading and that of \u03b3 subunit expression of AChRs between the convex and concave side in Group A. CONCLUSION. The denervation of paraspinal muscles is present in some patients with scoliosis associated with syringomyelia. The size of the syrinx and the degree of cerebellar tonsillar descent might seem to have no relation to the denervation of paraspinal muscles. \u00a9 2007 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Acetylcholine receptor",
            "Immunofluorescence",
            "Paraspinal muscles",
            "Pathogenesis",
            "Scoliosis",
            "Syringomyelia"
        ],
        "venue": "Spine",
        "year": 2007,
        "id": "I1eeXtZY"
    },
    "VpPmNbbU": {
        "authors": [
            {
                "name": "Liu-Dong Li",
                "org": ""
            },
            {
                "name": "Miao Tian",
                "org": ""
            },
            {
                "name": "Yu-Hua Liao",
                "org": ""
            },
            {
                "name": "Zi-Hua Zhou",
                "org": ""
            },
            {
                "name": "Fen Wei",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Yu-Miao Wei",
                "org": ""
            }
        ],
        "title": "Effect of active immunization against angiotensin II type 1 (AT1) receptor on hypertension & arterial remodelling in spontaneously hypertensive rats (SHR)",
        "abstract": "Background & objectives: Angiotensin II receptor type 1 (ATI) is known to be involved in the pathogenesis of hypertension. This study was undertaken to explore the effect of active immunization against AT1 receptor on blood pressure and small artery remodelling in spontaneously hypertensive rat (SHR). Methods: Male SHR and Wistar rats aged two months were actively immunized with different peptides (ATR12185 ATR10014 and ATR12181) corresponding to particular sequences of rat AT1 receptor, while another SHR group was given losartan (10 mg/kg/day) orally once a day. Anti-AT1 receptor antibodies were detected by ELISA and blood pressure was measured. The effect of the antibodies on the artery and vascular smooth muscle cells (VSMCs) proliferation was studied. Results: All immunized animals produced antibodies against the particular peptides. The systolic blood pressure was decreased in the SHR immunized with peptide-ATR12181 compared with the control. However, no changes were observed in the SHR immunized with other two peptides. The Wistar rats immunized with the three peptides did not show any changes in blood pressure. The media/lumen area ratio of the mesenteric artery was reduced in SHR immunized with ATR12181 and similar to that of the SHR treated with losartan. The antibody from SHR immunized with ATR12181 had no effect on the proliferation of VSMC. But it could inhibit the proliferation caused by angiotensin II and its effect at the titre of 1:40 was similar to that of 1u,mol/l losartan. Interpretation & conclusions: Our findings demonstrated that the antibody from SHR immunized with ATR12181 had the effect of reducing blood pressure and target organ protection similar to losartan. Active immunization against AT1 receptor may be a promising strategy in future for the treatment of hypertension.",
        "keywords": [
            "Antibody",
            "AT1 receptor",
            "Proliferation",
            "SHR",
            "Vascular smooth muscle cell"
        ],
        "venue": "Indian Journal of Medical Research",
        "year": 2014,
        "id": "VpPmNbbU"
    },
    "fPtp5eDz": {
        "authors": [
            {
                "name": "Hongda Bao",
                "org": "Spine Surgery"
            },
            {
                "name": "Peng Yan",
                "org": "Spine Surgery"
            },
            {
                "name": "Baron Lonner",
                "org": "Department of Orthopaedic Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Yuan Ren",
                "org": "Department of Orthopaedic Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhen Liu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Validation of the simplified Chinese version of the body image disturbance questionnaire-scoliosis",
        "abstract": "Study Design. Cross-cultural adaptation and validation of the Body Image Disturbance Questionnaire-Scoliosis (BIDQ-S). Objective. The aim of this study was to validate the Chinese version of BIDQ-S (C-BIDQ-S) in adolescent idiopathic scoliosis (AIS) patients in Mainland China. Summary of Background Data. A modified version of the Body Image Disturbance Questionnaire instrument has been validated in AIS patients (BIDQ-S) to assess the perception of spinal appearance and psychological disturbance. However, there is no culturally adapted, reliable, and validated BIDQ-S for the Chinese population. Method. The BIDQ-S was translated into simplified Chinese, and the cross-cultural adaptation of the original BIDQ-S was performed according to international guidelines. A total of 100 AIS patients were recruited into this study. Validation including reliability, internal consistency, and convergent validity was evaluated by comparing the C-BIDQ-S with Scoliosis Research Society (SRS)-22 and Spinal Appearance Questionnaire (SAQ) instruments. The relationship between C-BIDQ-S score and patient characteristics was also assessed. Results. Internal consistency for the C-BIDQ-S was satisfactory with a Cronbach alpha value of 0.877. The construct validity test demonstrated significant correlations between the C-BIDQ-S score and all SRS-22 domains as well as between the C-BIDQ-S score and most of SAQ domains. Although the C-BIDQ-S score was not correlated with age or BMI, patients with Cobb angle >40\u00b0 presented a significantly higher (poorer) C-BIDQ-S score. Conclusion. The Simplified Chinese version of BIDQ-S showed good internal consistency, strong psychometric properties, and satisfactory reliability. This concise questionnaire is suitable for widespread use in Mainland China.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Body image disturbance questionnaire-scoliosis",
            "Psychological disturbance",
            "Validation"
        ],
        "venue": "Spine",
        "year": 2015,
        "id": "fPtp5eDz"
    },
    "4s8T6prQ": {
        "authors": [
            {
                "name": "Ming-Zhuo Liu",
                "org": "Department of Burns, The First Affiliated Hospital of Nanchang University"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medcine, The First Affiliated Hospital of Nanchang University"
            }
        ],
        "title": "Advances in non-muscle myosin II (NMII) research",
        "abstract": "Non-muscle myosin II (NMII) acts as key roles in the broad ranges of basic biological functions, such as mitosis, migration, cytokinesis, vesicle metastasis repair and secretion etc., and conserved from unicellular organisms to humans. Its expression is closely related with functions of cells and therefore there has great significance. In this paper, the latest advances of NMII in physiological and pathological functions are reviewed.",
        "keywords": [
            "Apoptosis",
            "Cell repair",
            "Cell sectetion",
            "Cytokinesis",
            "Migration and adhesion",
            "Non-muscle myosin II (NMII)",
            "Organ development"
        ],
        "venue": "Fudan University Journal of Medical Sciences",
        "year": 2014,
        "id": "4s8T6prQ"
    },
    "8wieUbFc": {
        "authors": [
            {
                "name": "Zhifa Zhang",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Ling Xiao",
                "org": ""
            },
            {
                "name": "Min Wang",
                "org": ""
            },
            {
                "name": "Rui Tian",
                "org": ""
            },
            {
                "name": "Chengjian Shi",
                "org": ""
            },
            {
                "name": "Renyi Qin",
                "org": ""
            }
        ],
        "title": "Side population cells in human gallbladder cancer cell line GBC-SD regulated by TGF-\u00df-induced epithelial-mesenchymal transition",
        "abstract": "Mounting evidence has shown that side population (SP) cells are enriched for cancer stem cells (CSCs) responsible for cancer malignancy. In this study, SP technology was used to isolate a small subpopulation of SP cells in human gallbladder cancer cell line GBC-SD, and SP cells which had superior potential for proliferation in vitro and tumorigenesis in vivo were identified. Importantly, the abundance of GBC-SD SP cells was increased by a transforming growth factor-\u03b2 (TGF-\u03b2)-induced epithelial- mesenchymal transition (EMT), and this effect was accompanied with a strong up-regulation of ABCG2 mRNA expression, and a decreased sensitivity to mitoxantrone. SP cells were restored upon the removal of TGF-\u03b2 and the reversion of the cells to an epithelial phenotype, and smad3-specific siRNA reduced SP abundance in response to TGF-\u03b2. In conclusion, TGF-\u03b2-induced EMT by smad-dependent signaling pathway promotes cancer development and anti-cancer drug resistant phenotype by augmenting the abundance of GBC-SD SP cells, and a better understanding of mechanisms involved in TGF-\u03b2-induced EMT may provide a novel strategy for preventing cancer progression. \u00a9 Huazhong University of Science and Technology and Springer-Verlag Berlin Heidelberg 2011.",
        "keywords": [
            "Epithelial-mesenchymal transition",
            "Side population cells",
            "Transforming growth factor-\u03b2"
        ],
        "venue": "Journal of Huazhong University of Science and Technology - Medical Science",
        "year": 2011,
        "id": "8wieUbFc"
    },
    "wvKI8xei": {
        "authors": [
            {
                "name": "Wei-Jun Wang",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Ai-Bing Huang",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Xu Sun",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital, Nanjing University Medical School"
            }
        ],
        "title": "Does curve convexity affect the surgical outcomes of thoracic adolescent idiopathic scoliosis?",
        "abstract": "Background: Major left thoracic (LT) curve is an atypical type in adolescent idiopathic scoliosis (AIS) and showed independent clinical characteristics and natural history compared to major right thoracic (RT) curve. However, it's unclear whether the convexity of major thoracic curve would affect the surgical outcomes and risk of complications. A retrospective follow-up study was conducted to investigate whether the convexity of major thoracic curve would affect the surgical outcomes of patients with main thoracic AIS. Methods: Twelve LT-AIS patients underwent corrective spinal instrumentation and fusion were retrieved, and twelve patients with main RT-AIS matched for gender, chronological age, curve type, magnitude and surgical strategy were selected as control. All patients underwent at least 2-year follow-up. The pre- and post-operative radiographic parameters, intraoperative data and functional outcome assessed by Scoliosis Research Society questionnaire 22 (SRS-22) were analyzed and compared between two groups. Results: Patients with LT- and RT-AIS presented with similar magnitudes of thoracic curves, flexibility, fusion level and correction rate. Compared with RT-AIS, patients with LT-AIS showed longer operation time (average, 364 vs. 348 min) and larger amount intraoperative estimated blood loss (2,060 vs. 1,720 ml) although the differences were not statistically significant (p > 0.05). With at least 2-year follow-up, patients in two groups showed comparable loss of correction, coronal and sagittal balance, and the sagittal profiles. With regard to functional outcome, the scores of five categories of SRS-22 questionnaire were similar between two groups. No neurological or vascular complication was observed in these patients. Conclusions: The radiographic and functional outcomes of LT-AIS patients underwent operation were comparable to those with RT-AIS. Longer operation time and more intraoperative blood loss may be expected in instrumentation and fusion for patients with LT-AIS, which might be because of the inconvenience on the surgical procedure. \u00a9 2014 Springer-Verlag France.",
        "keywords": [
            "Adolescent",
            "Correction",
            "Direction",
            "Idiopathic scoliosis",
            "Thoracic"
        ],
        "venue": "European Journal of Orthopaedic Surgery and Traumatology",
        "year": 2014,
        "id": "wvKI8xei"
    },
    "OGhLtupd": {
        "authors": [
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Leilei Xu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Long Jiang",
                "org": ""
            },
            {
                "name": "Zhou Wang",
                "org": ""
            },
            {
                "name": "Zhen Liu",
                "org": ""
            },
            {
                "name": "Bang-Ping Qian",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Sagittal alignment of spine and pelvis in asymptomatic adults: Norms in Chinese populations",
        "abstract": "STUDY DESIGN.: A prospective, cross-sectional study. OBJECTIVE.: To investigate the normal values of sagittal spinal and pelvic parameters in Chinese populations and to determine the influence of age, sex, weight, and ethnicity on variations of these parameters. SUMMARY OF BACKGROUND DATA.: A few studies have been conducted to evaluate the morphology and orientation of pelvis in asymptomatic adults of Caucasian populations. However, there is still a lack of investigation concerning the normal range of spinal and pelvic alignment in Asian populations. METHODS.: A cohort of 260 asymptomatic adult volunteers from Chinese Han populations was prospectively recruited. The following 6 radiological parameters on lateral radiograph were evaluated for each subject, including sacral slope (SS), pelvic tilt, pelvic incidence, thoracic kyphosis, lumbar lordosis, and C7 tilt. Comparisons of these parameters between the male and the female and between Chinese Han populations and Caucasian populations were carried out with Student t tests. The relationships between all parameters and age and weight were assessed using the Pearson correlation analysis. RESULTS.: The mean values of spinopelvic parameters of the cohort were 44.6 \u00b1 11.2 for pelvic incidence, 11.2 \u00b1 7.8 for pelvic tilt, and 32.5 \u00b1 6.5 for SS, respectively. With the age matched, subjects from Chinese populations were found to have significantly smaller pelvic incidence and SS than those from Caucasian populations. The females were found to have significantly higher lumbar lordosis than the males. Presenting significant but small correlations with age of both male and female adults, thoracic kyphosis and pelvic tilt tended to increase with age, whereas SS had a tendency to decrease with age. Weight was significantly correlated with thoracic kyphosis, SS, and lumbar lordosis. CONCLUSION.: The normal values of sagittal spinal and pelvic parameters in Chinese populations could be significantly influenced by age, weight, and sex. Moreover, obvious variations of spinopelvic parameters were found between populations with different ethnicity background. \u00a9 2013, Lippincott Williams & Wilkins.",
        "keywords": [
            "Chinese populations",
            "Normal value",
            "Sagittal spinal alignment"
        ],
        "venue": "Spine",
        "year": 2014,
        "id": "OGhLtupd"
    },
    "i6UcdvIJ": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Hongda Bao",
                "org": ""
            },
            {
                "name": "Zhen Liu",
                "org": ""
            },
            {
                "name": "Saihu Mao",
                "org": ""
            },
            {
                "name": "Shouyu He",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Analysis of L5 incidence in normal population use of L5 incidence as a guide in reconstruction of lumbosacral alignment",
        "abstract": "Study Design. Cross-sectional study. Objective. To establish a statistic model defining the relationship between L5 incidence (L5I) and pelvic incidence (PI) in normal population and to illustrate the importance of L5I in maintaining the normal sagittal profile of spine. Summary of Background Data. L5I was proposed for the evaluation of postoperative improvements in high-grade isthmic spondylolisthesis. It has been proven that a postoperative improvement in L5I was correlated with a better surgical outcome, indicating that the restoration of L5I is important in restoring normal sagittal balance and spinal morphology. Methods. This retrospective study recruited 138 healthy volunteers, who were stratified into 2 groups according to age: adolescent group (13-18 yr) and adult group (19-35 yr). Parameters including PI, pelvic tilt, sacral slope, lumbar lordosis (LL), upper arc of the LL, lower arc of the LL, L5I, lumbosacral angle, and height of L5-S1 disc were measured on the long-cassette standing upright lateral radiographs of the spine and pelvis. The relations between all parameters were determined via the Pearson correlation coefficient (r). Linear regression was applied to model the relationship between PI and L5I. Results. This study demonstrated significant correlation between L5I and PI with a coefficient of 0.818, and a formula based on linear regression was established to estimate the ideal L5I from PI as follows: L5I = 0.725 PI - 12.757. Pelvic tilt, sacral slope, lumbosacral angle, LL, lower arc of the LL, and height of L5-S1 disc were also found strongly correlated with L5I, whereas no correlation was found between upper arc of the LL and L5I. Conclusion. Strong correlations were found between L5I and spinopelvic parameters in healthy subjects, indicating that L5I was an important parameter in local lumbosacral alignment. Ideal postoperative L5I could be mathematically calculated by PI according to the formula as follows: L5I = 0.725 PI - 12.757, suggesting that calculated ideal L5I could be regarded as a guide in surgical decision making. Copyright \u00a9 2014 Lippincott Williams & Wilkins.",
        "keywords": [
            "L5 incidence",
            "Pelvic incidence",
            "Spondylolisthesis",
            "Surgical planning"
        ],
        "venue": "Spine",
        "year": 2014,
        "id": "i6UcdvIJ"
    },
    "p4xuhL7Y": {
        "authors": [
            {
                "name": "Fen Wei",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Xiu-Jie Jia",
                "org": "Hospital of Hua Zhong Normal University"
            },
            {
                "name": "Su-Qin Yu",
                "org": "Wuhan Puai Hospital"
            },
            {
                "name": "Ye Gu",
                "org": "Wuhan Puai Hospital"
            },
            {
                "name": "Li Wang",
                "org": "Hospital of Huazhong University of Science and Technology"
            },
            {
                "name": "Xiao-Mei Guo",
                "org": "Tongji Hospital"
            },
            {
                "name": "Min Wang",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Feng Zhu",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Xiang Cheng",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Yu-Miao Wei",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Zi-Hua Zhou",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Micheal Fu",
                "org": "Department of Medicine"
            },
            {
                "name": "Yu-Hua Liao",
                "org": "Institute of Cardiology"
            }
        ],
        "title": "Candesartan versus imidapril in hypertension: A randomised study to assess effects of anti-AT1 receptor autoantibodies",
        "abstract": "Background: Anti-angiotensin II receptor subtype 1 (AT1 receptor) autoantibodies have previously been shown in sera of hypertensive patients. This study assessed whether anti-AT1-receptor autoantibody in serum is correlated with the efficacy of an AT1-receptor blocker (ARB; candesartan)-based regimen in hypertensive patients after 8 weeks of treatment. Design: The Study of Optimal Treatment in Hypertensive Patients with Anti-AT1-Receptor Autoantibodies is a multicentre, randomised, blinded endpoint, open-label, parallel-group comparison clinical trial conducted in five centres in Wuhan, China. Treatment is designed as stepwise added-on therapy to reduce blood pressure (BP) <140/90 mm Hg. 512 patients with moderate to severe primary hypertension were randomly assigned to an 8-week treatment with either ARB (candesartan)-based regimen (n=257) or ACE inhibitor (imidapril)-based regimen (n=255). Results: Systolic and diastolic BP was reduced significantly in both treatment groups. The candesartan-based regimen achieved a significantly greater systolic BP reduction than imdapril (30.8\u00b110.3 vs 28.8\u00b110.3 mm Hg, p=0.023). In those anti-AT1 receptor autoantibody-positive hypertensive patients, the mean systolic BP at baseline was higher than in the anti-AT1 receptor autoantibody-negative group (160.5\u00b116.5 vs 156.2\u00b117.7 mm Hg; p=0.006). The mean BP reduction was greater in the candesartan-based regimen than the imidapril-based regimen (-35.4\u00b19.8/16.9\u00b16.9 vs -29.4\u00b19.8/14.2\u00b16.9 mm Hg; p=0.000 and 0.002, respectively), and more patients on imidapril required add-on medications to achieve BP control (94% vs 86%; p=0.03). No correlation was observed between the titre of anti-AT1 receptor autoantibody and the efficacy of candesartan-based therapy. In those anti-AT1 receptor autoantibody-negative patients similar BP lowering was reached in the candesartan and the imidapril-based regimens. Conclusions: An ARB-based regimen is more effective in BP lowering than an ACE inhibitor-based regimen in the presence of anti-AT1 receptor autoantibodies. Trial registration number: This trial has been registered at http://www.register.clinicaltrials.gov/ (identifier: NCT00360763).",
        "keywords": [
            ""
        ],
        "venue": "Heart",
        "year": 2011,
        "id": "p4xuhL7Y"
    },
    "L4uWtjHg": {
        "authors": [
            {
                "name": "Xu Sun",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Tao Wu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Zhen Liu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Bangping Qian",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Feng Zhu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Weiwei Ma",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yang Yu",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Bin Wang",
                "org": "Affiliated Drum Tower Hospital"
            },
            {
                "name": "Yong Qiu",
                "org": "Affiliated Drum Tower Hospital"
            }
        ],
        "title": "Osteopenia predicts curve progression of adolescent idiopathic scoliosis in girls treated with brace treatment",
        "abstract": "Background: Previous studies have shown a significant association between osteopenia and adolescent idiopathic scoliosis (AIS). And initial bone mineral density (BMD) was proposed to serve as a new prognostic factor of curve progression in AIS. However, it remains unknown whether there is a link between the initial bone mineral status and the outcome of brace treatment. This study aimed to investigate whether the initial bone mineral status could influence the final outcome of brace treatment in AIS. Methods: Girls with AIS treated with brace treatment were recruited. These patients either completed brace treatment, or were indicated for correction surgery with a curve magnitude of >45 degrees. Patients with a progressed scoliosis (group A) and those with a nonprogressed scoliosis (group B) were identified. The associations between the bracing outcome and the indices before bracing, including growth status, anthropometric measurements, BMD status, curve magnitude, and curve pattern were evaluated using univariate analysis and regression analysis. Results: Sixty-eight patients were included. There were 17 girls (25%) in group A and 51 girls (75%) in group B, respectively. The girls in group A had a significantly larger initial Cobb angle (32.3\u00b16.6 vs. 29.1\u00b15.3 degrees), a significantly lower BMD of lumbar spine from L2 to L4 value (0.80\u00b10.11 vs. 0.88\u00b10.12 g/ cm2), and a marginally significantly lower Risser grade (1.4\u00b11.5 vs. 2.2\u00b11.4), than in group B. In comparison with group B, more girls in group A were found to be premenarche (P=0.008), osteopenic (P=0.003), with a lower Risser grade (P=0.079), a greater curve magnitude (P=0.159), and a main thoracic pattern (P=0.122) before the initiation of bracing treatment. As revealed by the multiple logistic regression analysis, osteopenia (P=0.002) was identified as an independent risk factor in curve progression in AIS girls, during the total duration of bracing treatment. Conclusions: Osteopenia is identified to serve as a new independent risk factor in the curve progression during the duration of bracing treatment. The evaluation of initial BMD status before bracing may help to predict the outcome of brace treatment. Copyright \u00a9 2013 by Lippincott Williams & Wilkins.",
        "keywords": [
            "Bone mineral density",
            "Brace treatment",
            "Idiopathic scoliosis",
            "Predictor",
            "Progression"
        ],
        "venue": "Journal of Pediatric Orthopaedics",
        "year": 2013,
        "id": "L4uWtjHg"
    },
    "6eqKUM2A": {
        "authors": [
            {
                "name": "Yun-Fei Duan",
                "org": "Department of General Surgery, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Wei Xue",
                "org": "Department of General Surgery, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of General Surgery, Third Affiliated Hospital, Soochow University"
            },
            {
                "name": "Dong-Lin Sun",
                "org": "Department of General Surgery, Third Affiliated Hospital, Soochow University"
            }
        ],
        "title": "FOCUS harmonic scalpel compared to conventional hemostasis in open total thyroidectomy - A prospective randomized study",
        "abstract": "Background: Hemostasis in thyroid surgery is of utmost importance for a successful surgery and an uneventful postoperative course. Our aim was to evaluate the effectiveness of the FOCUS Harmonic Scalpel in patients undergoing open total thyroidectomy. Methods: In this study, 778 patients were randomized into 2 groups based on the surgical technique used: group I comprised the conventional clamp-and-tie technique, group II comprised patients in whom the FOCUS Harmonic Scalpel was used exclusively. The groups were compared in regard to surgical time, complications, and hospital stay. Results: Surgical time was significantly lower in group II compared with group I (79 \u00b1 21.5 min vs.125 \u00b1 30.4, respectively, P < 0.001). Twenty-seven patients (6.94%) in group I experienced symptomatic hypocalcemia requiring calcium and/or vitamin D therapy versus 14 patients (3.6%) in group II, with statistically significant difference (P < 0.05). Mean post-operative hospital stay was significantly lower in group II compared with group I (2.6 \u00b1 0.9 vs. 2.9 \u00b1 1.0; P < 0.001). Conclusions: The FOCUS Harmonic Scalpel can shorten operative time and hospital stay, reduce incidence of symptomatic hypocalcemia but not transient hypoparathyroidism, and show no significance on recurrent nerve injury. FOCUS Harmonic Scalpel is supposed to be a more reliable and safe instrument that can take place of the clamp-and-tie technique in total thyroidectomy. \u00a9 2013 Duan et al.; licensee BioMed Central Ltd.",
        "keywords": [
            "Harmonic Scalpel",
            "Hemostasis",
            "Hypocalcemia",
            "Hypoparathyroidism",
            "Thyroid surgery",
            "Total thyroidectomy"
        ],
        "venue": "Journal of Otolaryngology - Head and Neck Surgery",
        "year": 2013,
        "id": "6eqKUM2A"
    },
    "WokWXv8c": {
        "authors": [
            {
                "name": "Wenyuan Lu",
                "org": "Shanghai Jiaotong Univ."
            },
            {
                "name": "Yan Zhang",
                "org": "Shanghai Jiaotong Univ."
            },
            {
                "name": "Yong Zhang",
                "org": "Shanghai Jiaotong Univ."
            },
            {
                "name": "Feng Zhu",
                "org": "Shanghai Jiaotong Univ."
            }
        ],
        "title": "Research on the optimum equivalent availability factor of a large scale turbo generator",
        "abstract": "The main factors affecting equivalent availability factor (EAF) of a turbo generator are analyzed, and the proportional age setback (PAS) model of the turbo generator considering the planned maintenance is presented. Based on this model, the optimum EAF model of a large-scale turbo generator is deduced by using cost-effectiveness analysis. Moreover, the optimum EAF of a large-scale thermal plant in East China is calculated. The calculation results show that it exits an optimum planned maintenance interval of a turbo generator, and correspondingly, the EAF also has an optimum value in order to achieve the maximum long-term economical operation benefits. So it's not good to sacrifice the essential planned maintenance hours for the high short-term EAF value and economical benefit.",
        "keywords": [
            "Equivalent age",
            "Equivalent availability factor",
            "Maintenance effectiveness",
            "Reliability",
            "Turbo generator"
        ],
        "venue": "Dianli Xitong Zidonghue/Automation of Electric Power Systems",
        "year": 2002,
        "id": "WokWXv8c"
    },
    "ZFx3IyvQ": {
        "authors": [
            {
                "name": "Wensong Liu",
                "org": "Departments of Hepatobiliary Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Departments of Hepatobiliary Surgery"
            },
            {
                "name": "Yong Jiang",
                "org": "Departments of Hepatobiliary Surgery"
            },
            {
                "name": "Donglin Sun",
                "org": "Departments of Hepatobiliary Surgery"
            },
            {
                "name": "Bo Yang",
                "org": "Departments of Hepatobiliary Surgery"
            },
            {
                "name": "Haijiao Yan",
                "org": "Department of Oncology"
            }
        ],
        "title": "siRNA targeting survivin inhibits the growth and enhances the chemosensitivity of hepatocellular carcinoma cells",
        "abstract": "Survivin has become an attractive anticancer therapeutic target due to its important role in tumor cell viability and its selective expression in tumor cells. In the present study, we constructed a recombinant siRNA plasmid vector against survivin and stably transfected it into HepG2 and SMMC-7721 hepatocellular carcinoma cells in vitro. Semi-quantitative RT-PCR and western blotting were used to determine the expression of survivin mRNA and protein, respectively. Tumor cell proliferation was assessed by trypan blue exclusion. We evaluated the change in caspase-3 activity, and the rate of cell apoptosis and the cell cycle distribution were analyzed by flow cytometry. Assessment of chemosensi-tivity was carried out by MTT assay. The results showed that transfection of survivin siRNA caused a significant inhibition of survivin mRNA and protein expression which was associated with cell growth inhibition, specific G0/G1 phase arrest, increased caspase-3 activity and enhanced chemosensitivity to cisplatin in both HCC cell lines. We suggest that suppression of survivin expression by RNAi attenuates the malignant phenotype of hepatocellular carcinoma cells, and may provide a novel approach for anticancer gene therapy.",
        "keywords": [
            "Chemosensitivity",
            "Hepatocellular carcinoma",
            "RNA interference",
            "Survivin"
        ],
        "venue": "Oncology Reports",
        "year": 2013,
        "id": "ZFx3IyvQ"
    },
    "bqgbvqab": {
        "authors": [
            {
                "name": "Zhen Liu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Jing Guo",
                "org": "Spine Surgery"
            },
            {
                "name": "Saihu Mao",
                "org": "Spine Surgery"
            },
            {
                "name": "Weijun Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Bangping Qian",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Winnie Chu",
                "org": "Department of Diagnostic Radiology and Organ Imaging"
            },
            {
                "name": "Jack C.Y. Cheng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Yong Qiu",
                "org": "Joint Scoliosis Research Center"
            }
        ],
        "title": "Analysis of body growth parameters in girls with adolescent idiopathic scoliosis: Single thoracic idiopathic scoliosis versus single lumbar idiopathic scoliosis",
        "abstract": "Abnormal pattern of growth has been reported in adolescent idiopathic scoliosis (AIS) patients. However, the sequential changes of growth in different curve types of AIS have not been properly studied. The present study aimed to investigate the body growth characteristics of girls with single thoracic idiopathic scoliosis and lumbar idiopathic scoliosis in China. 339 AIS girls and 3914 healthy girls, aged 10\u223c17yr, were included. All AIS girls had a mean Cobb angle of 32\u00b110\u00b0 (range 15\u223c63\u00b0). According to the locations of curves end vertebrae, AIS girls were divided into 2 subgroups: a single thoracic curve and a single lumbar curve. Body weight and standing height was measured, and body mass index (BMI) and leg length was calculated of each subject in three groups, and corrected height was computed in AIS group according to Bjure's formula. One-way ANOVA was used to determine the differences in weight, height, corrected height and BMI between AIS and healthy girls. Standing height and sitting height showed no significant difference between thoracic scoliosis and lumbar scoliosis girls. Compared to healthy girls at the same age, thoracic and lumbar AIS girls had a significantly higher corrected standing and sitting height, arm span and leg length. Thoracic AIS girls had a significantly lower body weight than healthy girls at the age of 15yr. Yet, body weight showed no significant difference between lumbar AIS and healthy girls. The standing and sitting height between thoracic and lumbar AIS girls were similar during the pubertal period. Compared to healthy girls at the same age, thoracic and lumbar AIS girls had a significantly higher corrected standing, sitting height and leg length. In addition, thoracic AIS girls are leaner than healthy girls. \u00a9 2012 The authors and IOS Press. All rights reserved.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Body growth pattern",
            "Single lumbar idiopathic scoliosis",
            "Single thoracic idiopathic scoliosis"
        ],
        "venue": "Studies in Health Technology and Informatics",
        "year": 2012,
        "id": "bqgbvqab"
    },
    "rXLFz6bc": {
        "authors": [
            {
                "name": "Xu-Sheng Qiu",
                "org": "Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Hua Jiang",
                "org": "Department of Spine Surgery, First Affiliated Hospital of Guangxi Medical University"
            },
            {
                "name": "Bang-Ping Qian",
                "org": "Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Wei-Jun Wang",
                "org": "Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            }
        ],
        "title": "Influence of prone positioning on potential risk of aorta injury from pedicle screw misplacement in adolescent idiopathic scoliosis patients",
        "abstract": "Study Design: A prospective magnetic resonance imaging (MRI) study. Objective: The aim of this study was to quantitatively analyze the potential risks of aorta injury from thoracic pedicle screw (TPS) misplacement in right thoracic adolescent idiopathic scoliosis (RT-AIS) patients who are in the prone position. Summary of Background Data: The aorta injuries are rare during posterior spinal surgery, but they can result in catastrophic complications when they do occur. However, we are aware of no prior studies that have used MRI images obtained with patients in the prone position for the Purpose of systematically evaluating the potential risks of aorta injury due to TPS misplacement. MATERIALS AND Methods: This prospective study included 38 RT-AIS patients who underwent MRI scans in the prone position. We evaluated on the MRI images the aorta position relative to the scoliotic spine, and simulated placement of a left TPS with a lateral deviation different from the medium trajectory using Surgimap Spine imaging software. The maximum error of lateral direction was set to 10, 20, or 30 degrees (3 scenarios), and the length of the TPS was set at 30, 35, or 40 mm (3 scenarios). Sensitivity analysis was performed by variable direction errors and TPS lengths. The potential risk of aorta impingement was defined as the virtual TPS crossing the aorta. The percentages of potential risk of aorta impingement were calculated at each level in 9 scenarios. Results: In the RT-AIS patients, the aorta shifted gradually from the left side of the vertebrae at midthoracic levels to a more anterior position at the lower thoracic levels, and was close to the vertebral body at T5-T6 and far away from the left cortex of vertebrae at T12. In 9 scenarios, with the increment of the lengths or/and direction errors of the simulated TPS, the risks of aorta impingement were consistently elevated at all the levels. The simulated 40 mm TPS at T5, T6, and T11 posed a higher potential risk of aorta injury (66%-74%) with a 30-degree lateral direction error. Conclusions: Prone positioning may increase the potential risk of aorta injury in RT-AIS patients, particularly at T5-T6 and T11 even if a left TPS just barely touches the anteriolateral or lateral cortex of the vertebrae. Laterally misplaced TPSs should be removed at these high aorta-at-risk levels. \u00a9 2014 by Lippincott Williams & Wilkins.",
        "keywords": [
            "adolescent idiopathic scoliosis",
            "aorta impingement",
            "MRI",
            "prone"
        ],
        "venue": "Journal of Spinal Disorders and Techniques",
        "year": 2014,
        "id": "rXLFz6bc"
    },
    "8Q0XA55X": {
        "authors": [
            {
                "name": "Weijun Wang",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Winnie C. W. Chu",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Jack C. Y. Cheng",
                "org": "Joint Scoliosis Research Center"
            },
            {
                "name": "Yong Qiu",
                "org": "Joint Scoliosis Research Center"
            }
        ],
        "title": "The changes of relative position of the thoracic aorta after anterior or posterior instrumentation of type I Lenke curve in adolescent idiopathic thoracic scoliosis",
        "abstract": "The risk of impingement of the aorta associated with thoracic vertebral screw or pedicle screw instrumentation in the treatment of thoracic scoliosis has been an important concern. To understand this phenomenon more systematically, the relative position of the aorta with reference to the thoracic vertebrae in right thoracic adolescent idiopathic scoliosis (AIS) following anterior and posterior spinal instrumentation was analyzed in detail quantitatively; 34 patients underwent anterior (n = 14) or posterior (n = 20) spinal instrumentation were recruited in the present study. The relative position of the thoracic aorta, vertebral rotation, apical vertebral translation and thoracic kyphosis were measured from pre- and post-operative CT images from T5 to T12. The aorta was found to shift antero-medially in the anterior instrumentation group but not in the posterior spinal instrumentation group. It is likely that the disc removal, soft tissue release and spontaneous vertebral derotation of the scoliosis could account for the antero-medial shifting of the aorta. By the shifting, the space for contralateral screw penetration was reduced. \u00a9 2008 Springer-Verlag.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Anterior instrumentation",
            "Computed tomography",
            "Shift",
            "Thoracic aorta"
        ],
        "venue": "European Spine Journal",
        "year": 2008,
        "id": "8Q0XA55X"
    },
    "PTbuL7hI": {
        "authors": [
            {
                "name": "Hang Zhao",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            },
            {
                "name": "Jie Sun",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            },
            {
                "name": "Xiangjun Meng",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            }
        ],
        "title": "Meta-analysis of the association between NQO1 Pro187Ser polymorphism and colorectal cancer in Asians",
        "abstract": "There were a number of studies performed to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians, but no consensus was available up to now. We conducted a meta-analysis to assess the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians. Case-control studies investigating the association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians were searched in Pubmed and Wanfang databases. Pooled odds ratio (OR) and 95 % confidence interval (95 % CI) was calculated. Finally, seven studies involving a total of 2,051 cases and 2,798 controls met the inclusion criteria and were included into the meta-analysis. Overall, there was an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians (Ser versus Pro: OR = 1.42, 95 % CI 1.08-1.87, P = 0.013; SerSer versus ProPro: OR = 1.86, 95 % CI 1.08-3.19, P = 0.024; SerSer/ProSer versus ProPro: OR = 1.61, 95 % CI 1.10-2.35, P = 0.014; SerSer versus ProPro/ProSer: OR = 1.46, 95 % CI 1.02-2.10, P = 0.041). There was low risk of publication bias in the meta-analysis. This meta-analysis suggests that there is an obvious association between NQO1 Pro187Ser polymorphism and colorectal cancer risk in Asians. \u00a9 2013 International Society of Oncology and BioMarkers (ISOBM).",
        "keywords": [
            "Asians",
            "Colorectal cancer",
            "Meta-analysis",
            "NQO1"
        ],
        "venue": "Tumor Biology",
        "year": 2014,
        "id": "PTbuL7hI"
    },
    "CFM2q97p": {
        "authors": [
            {
                "name": "Weijun Wang",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Chao Sun",
                "org": ""
            },
            {
                "name": "Zhiwei Wang",
                "org": ""
            },
            {
                "name": "Xu Sun",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            }
        ],
        "title": "Different curve pattern and other radiographical characteristics in male and female patients with adolescent idiopathic scoliosis",
        "abstract": "STUDY DESIGN.: Retrospective radiographical study. OBJECTIVE.: To compare the sex differences in curve patterns and radiographical characteristics in patients who have adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA.: Sex differences in AIS have been documented in the incidence of curve progression, response to bracing, and outcomes of surgical treatment. However, limited information is available about the relation between sex and scoliosis curve patterns and radiographical presentations. METHODS.: A total of 359 male and 999 female patients with AIS with major curve of 20\u00b0 or more were recruited. Standard posteroanterior and lateral radiographs of spine were reviewed to classify scoliosis curve patterns as typical or atypical and to measure curve severity and thoracic kyphosis. In 351 surgically treated patients, side-bending films were used to assess curve flexibility. Comparisons between male and female patients were made by subgrouping patients according to curve patterns and severity. RESULTS.: Atypical curves were more frequently observed in male (19.8%) than in female patients (8.9%) (P < 0.01). Sex differences were also found in the distribution of curve types. Main thoracic curve was the most common curve type in both sexes. Furthermore, significantly higher incidence of main thoracic curve in patients with severe AIS than in patients with moderate AIS was found in male (P < 0.001) but not in female patients. In patients with severe AIS who had typical curve patterns that included a major thoracic curve, male patients had larger magnitude of thoracic curve, more severe thoracic kyphosis, and more rigid thoracic and lumbar curves than female patients. CONCLUSION.: Atypical curve patterns were more predominant in male than in female patients with AIS. The thoracic curve in male patients with AIS might have higher incidence of progression than that in female patients. The higher rigidity of both thoracic and lumbar curves in male patients with AIS with severe curves might contribute to the lower curve correction rate and poor response to brace than in female cases. Copyright \u00a9 2012 Lippincott Williams & Wilkins.",
        "keywords": [
            "adolescent",
            "curve patterns",
            "flexibility",
            "idiopathic scoliosis",
            "neural axis",
            "sex",
            "thoracic kyphosis"
        ],
        "venue": "Spine",
        "year": 2012,
        "id": "CFM2q97p"
    },
    "YVgu6bLO": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            },
            {
                "name": "Hang Zhao",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            },
            {
                "name": "Xiaohui Tian",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            },
            {
                "name": "Xiangjun Meng",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University"
            }
        ],
        "title": "Association between tumor necrosis factor-\u03b1 rs1800629 polymorphism and risk of gastric cancer: A meta-analysis",
        "abstract": "Gastric cancer is mainly initiated by inflammation and chronic superficial gastritis, and tumor necrosis factor-\u03b1 (TNF-\u03b1) is an inflammatory cytokine which plays an important role in the inflammation. TNF-\u03b1 rs1800629 G/A polymorphism was proposed to be associated with gastric cancer risk, but previous studies on Caucasians reported conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-\u03b1 rs1800629 polymorphism and gastric cancer risk in Caucasians. The pooled odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to assess the association. Eleven case-control studies with 7,427 subjects were finally included into the meta-analysis. Overall, TNF-\u03b1 rs1800629 polymorphism was significantly associated with the increased risk of gastric cancer under four genetic comparison models (A versus G: OR = 1.32, 95 % CI 1.12-1.56, P = 0.001; AA versus GG: OR = 1.76, 95 % CI 1.37-2.26, P < 0.001; AA versus GG/GA: OR = 1.62, 95 % CI 1.27-2.07, P < 0.001; AA/GA versus GG: OR = 1.35, 95 % CI 1.14-1.60, P = 0.001). Meta-analysis of those studies with high quality showed that TNF-\u03b1 rs1800629 polymorphism was still significantly associated with the increased risk of gastric cancer under four genetic comparison models. There was no risk of publication bias in the meta-analysis. The meta-analysis suggests that TNF-\u03b1 rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians. \u00a9 2013 International Society of Oncology and BioMarkers (ISOBM).",
        "keywords": [
            "Gastric cancer",
            "Meta-analysis",
            "Polymorphism",
            "Tumor necrosis factor-\u03b1"
        ],
        "venue": "Tumor Biology",
        "year": 2014,
        "id": "YVgu6bLO"
    },
    "nVRoO6Nl": {
        "authors": [
            {
                "name": "Yun-Fei Duan",
                "org": "Department of Hepatobiliary Surgery"
            },
            {
                "name": "Yong Jiang",
                "org": "Department of Hepatobiliary Surgery"
            },
            {
                "name": "Chuan-Xing Wu",
                "org": "Department of Hepatobiliary Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Hepatobiliary Surgery"
            }
        ],
        "title": "Spontaneous rupture of primary splenic angiosarcoma: A case report and literature review",
        "abstract": "Background: Primary angiosarcoma of the spleen is a rare mesenchymal malignant tumor of vascular origin often with a poor prognosis, due to its high metastatic potential. This disease often presents with atraumatic rupture and lethal hemorrhage.Case presentation: We report a case of a 65-year-old man who presented with abdominal pain, anemia, thrombocytopenia, and palpable abdominal mass with unstable blood pressure. Laparotomy revealed a huge actively bleeding spleen, thus splenectomy was performed. Some liver metastasis foci were also found during the procedure. Histopathology diagnosis of the removed spleen was primary splenic angiosarcoma. The patient was discharged on the 10th day post operation with no complication.Conclusions: Splenic angiosarcoma should be considered one of the differential diagnoses in patients with spleen parenchymal lesions. Definitive diagnosis requires laparotomy followed by splenectomy. In the majority of the patients with spleen angiosarcoma, metastatic diseases have already occurred at the time of laparotomy, so splenectomy is an approach more for diagnostic purpose rather than curative purpose. \u00a9 2013 Duan et al; licensee BioMed Central Ltd.",
        "keywords": [
            "Neoplasm metastasis",
            "Sarcoma",
            "Spleen"
        ],
        "venue": "World Journal of Surgical Oncology",
        "year": 2013,
        "id": "nVRoO6Nl"
    },
    "vpKVbJie": {
        "authors": [
            {
                "name": "Xuehao Wei",
                "org": "School of Electronics, Information and Electrical Engineering"
            },
            {
                "name": "Feng Zhu",
                "org": "School of Electronics, Information and Electrical Engineering"
            },
            {
                "name": "Chuanwen Jiang",
                "org": "School of Electronics, Information and Electrical Engineering"
            },
            {
                "name": "Zhijian Hou",
                "org": "School of Electronics, Information and Electrical Engineering"
            }
        ],
        "title": "The blueprint and exploring of East China electricity market",
        "abstract": "The monthly market of East China Power Market (ECPM) started trial operation on May 18, 2004. This paper outlines the profile of the East China Power Grid and summarizes the development of ECPM. In particular, the paper describes the market structure that ECPM has selected, and analyzes the results of ECPM trial operation. The underlining rationale that determines the market behavior is explored, and recommendations for further improvement are provided.",
        "keywords": [
            "Empirical analysis",
            "Monthly market",
            "Power market",
            "Simulation"
        ],
        "venue": "WSEAS Transactions on Systems",
        "year": 2005,
        "id": "vpKVbJie"
    },
    "Y2DBQGpx": {
        "authors": [
            {
                "name": "Li Yuan",
                "org": "Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Mingxing Xie",
                "org": "Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Tsung O. Cheng",
                "org": "Department of Medicine, George Washington University Medical Center"
            },
            {
                "name": "Xinfang Wang",
                "org": "Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Cardiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Xiangquan Kong",
                "org": "Department of Radiology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology"
            },
            {
                "name": "Devina Ghoorah",
                "org": "Radiology Department, Flacq Hospital, Ministry of Life and Quality of Life"
            }
        ],
        "title": "Left ventricular noncompaction associated with hypertrophic cardiomyopathy: Echocardiographic diagnosis and genetic analysis of a new pedigree in China",
        "abstract": "Background Hypertrophic cardiomyopathy (HCM) and left ventricular noncompaction (LVNC) are both genetically determined and familial diseases that possess variable but overlapping genetic defects. Previous literature has mostly reported their occurrences as either separate disorders in different members of a family or coexisting entities in sporadic cases rather than familial cases. This study explored the echocardiographic diagnostic values and familial features in a family with coexistence of HCM and LVNC. Methods A four-generation family comprised of 30 members was studied; 28 members underwent familial screening by routine transthoracic echocardiography (TTE), contrast echocardiography (CE), and/or cardiac magnetic resonance imaging (cMRI). Echocardiographic and cMRI findings were then compared. Results Four members (13.3%) died of sudden death or heart failure. Eleven members (39%) suffered from HCM, LVNC or both. There were 13 left ventricular hypertrophic segments among the echocardiographic images of 9 locally archived patients, including septal, inferior and anterior wall segments (8, 3, 2 respectively) as well as 20 noncompaction segments, including lateral, apical, anterior, antero-septal and inferior wall segments (8, 5, 4, 2, 1 respectively). Left atrial dilatation and diastolic dysfunction were significant in these subjects. Findings from TTE and CE were in accordance with those from cMRI in lesion locations. CE provided more information about noncompaction segments located in the antero-septum and near field than TTE. Conclusions HCM and LVNC coexist in one Chinese family, with overlapping phenotypes and different ages, clinical manifestations and multimodality imaging findings. TTE is an excellent tool to diagnose HCM and LVNC with supplementation by CE. \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.",
        "keywords": [
            "Contrast echocardiography",
            "Familial screening",
            "Genetics",
            "Hypertrophic cardiomyopathy",
            "Left ventricular noncompaction"
        ],
        "venue": "International Journal of Cardiology",
        "year": 2014,
        "id": "Y2DBQGpx"
    },
    "ny0FhMyb": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Libing Yang",
                "org": ""
            },
            {
                "name": "Bin Fan",
                "org": ""
            },
            {
                "name": "Xuehao Wei",
                "org": ""
            },
            {
                "name": "Deqiang Gan",
                "org": ""
            }
        ],
        "title": "East China power market development and trial operation",
        "abstract": "The monthly market of East China Power Market (ECPM) started trial operation on May 18, 2004. This paper outlines the profile of the East China Power Grid and summarizes the development of ECPM. In particular, the paper describes the market structure that ECPM has selected, and analyzes the results of ECPM trial operation. The underlining rationale that determines the market behavior is explored, and recommendations for further improvement are provided. \u00a9 2005 IEEE.",
        "keywords": [
            "Empirical analysis",
            "Monthly market",
            "Power market",
            "Simulation"
        ],
        "venue": "2005 IEEE Power Engineering Society General Meeting",
        "year": 2005,
        "id": "ny0FhMyb"
    },
    "hLKtSFKv": {
        "authors": [
            {
                "name": "Xu Sun",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Xu-Sheng Qiu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Spine Surgery"
            },
            {
                "name": "Cai-Wei Xia",
                "org": "Department of Spine Surgery"
            }
        ],
        "title": "Association between circulating leptin level and anthropometric parameters in girls with adolescent idiopathic scoliosis",
        "abstract": "Objective: To investigate thee correlation between the circulating leptin level and the anthropometric parameters and parameters related to pubertal growth, and to explore the role of leptin in the abnormal growth pattern in girls with adolescent idiopathic scoliosis (AIS). Methods: One hundred and twenty AIS girls selected randomly from the out-patient and in-patient departments, divided into 2 groups: Group A1 (n=73, aged 10 - 13) and Group A2 (n=47, aged 14 - 7), and 80 14 - 17 year-old healthy girl students receiving physical examination underwent measurement of body height and weight. Body mass index (BMI) was calculated. Peripheral fasting blood samples were collected to detect the level of leptin. The anthropometric data, pubertal status, and circulating leptin level were compared between the AIS girls and the controls. The relationships between leptin and age, menstrual status, body weight, height, BMI and Risser sign were analyzed in the AIS girls. Results: Eighty-eight AIS girls (73%) and 14 healthy girls (18%) had a BMI score less than 18.0. The mean leptin level of Group A1 was 6.2 \u03bcg/L, significantly lower than of Group A2 (8.6 \u03bcg/L, P=0.024). Compared with the healthy controls, the AIS girls had significantly greater corrected height (162.7 cm vs. 160.2 cm, P=0.026), lower weight (44.3 kg vs. 53.6 kg, P=0.01), lower BMI (17.5 kg/m",
        "keywords": [
            "Bodyweight",
            "Child development",
            "Female, growth",
            "Leptin",
            "Scoliosis"
        ],
        "venue": "National Medical Journal of China",
        "year": 2007,
        "id": "hLKtSFKv"
    },
    "GN1mgqpr": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Spinal Service"
            },
            {
                "name": "Yong Qiu",
                "org": "Spinal Service"
            },
            {
                "name": "Hiu Yan Yeung",
                "org": "Department of Orthopaedics and Traumatology"
            },
            {
                "name": "Kwong Man Lee",
                "org": "Lee Hysan Clinical Research Laboratories"
            },
            {
                "name": "Jack Chun-Yiu Cheng",
                "org": "Department of Orthopaedics and Traumatology"
            }
        ],
        "title": "Histomorphometric study of the spinal growth plates in idiopathic scoliosis and congenital scoliosis",
        "abstract": "Background: Previous studies have suggested that the relative anterior spinal overgrowth may play an important role in the etiopathogenesis of spinal deformity in adolescent idiopathic scoliosis (AIS). Little is known about the histomorphometry of the anterior and posterior spinal growth plates. Methods: In the present study, the growth plates from the anterior and posterior column of the spine of the AIS (n = 9) and the congenital scoliosis (CS; n = 9) were harvested intraoperatively. The growth plates were harvested from apical area in AIS patients and from normal region in CS patients. The biopsies were prepared with routine histological methods for quantitative histomorphometric analysis. Apoptosis and cell proliferation of the growth plate chondrocytes were examined by triphosphate-biotin nick end labeling assay and immunohistochemistry of proliferating cell nuclear antigen antibody. Results: The growth plates of AIS and CS were shown to have normal architectures as the normal growth plate. However, it is shown that the proliferative and hypertrophic chondrocytes in the anterior column of AIS patients was more active in terms of the zonal area and height, proliferative chondrocytes, and apoptotic chondrocytes than that of the posterior column (P < 0.05). The difference found in AIS patients was not observed in CS patients. Conclusion: The difference in histomorphometry and cellular activity between the anterior and posterior column in AIS and CS patients indicated that these two groups of patients have different growth kinetics which may affect the curve development. \u00a9 2006 Blackwell Publishing Asia.",
        "keywords": [
            "Adolescent idiopathic scoliosis",
            "Chondrocytes",
            "Growth plate",
            "Pathogenesis",
            "Spine column"
        ],
        "venue": "Pediatrics International",
        "year": 2006,
        "id": "GN1mgqpr"
    },
    "VksN2PjV": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Ren-Sheng Chen",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Ke-Han Yu",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Song Huang",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Nian-Yun Wang",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Juan-Juan Xing",
                "org": "Department of Critical Care Medicine"
            }
        ],
        "title": "Observation on marrow-derived mesenchymal stem cells differentiating into functional cells in rabbit with smoke inhalation injury",
        "abstract": "Objective: To observe the homing and differentiation of marrow-derived mesenchymal stem cells (MSC) transplanted intravenously in smoke inhalation injured rabbits. Methods: Thirty-two New Zealand big ear rabbits were divided into normal control group (NC), inhalation injury group (II), normal control+ MSC treatment group (NM), and MSC treatment group (MT) according to the random number table, with 8 rabbits in each group. Rabbits in NC group were injected with 10 mL phosphate buffered saline (PBS) via ear marginal vein. Rabbits in NM group were injected with 10 mL PBS containing the third generation MSC labeled by BrdU (1 \u00d7 10 ",
        "keywords": [
            "Alveolar epithelial cell",
            "Burns, inhalation",
            "Cell differentiation",
            "Mesenchymal stem cells",
            "Pulmonary vascular endothelial cells"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2011,
        "id": "VksN2PjV"
    },
    "3WhrX9AF": {
        "authors": [
            {
                "name": "Guo-Xiang Yao",
                "org": ""
            },
            {
                "name": "Xin-Bo Xue",
                "org": ""
            },
            {
                "name": "Xing-Pei Lu",
                "org": ""
            },
            {
                "name": "Jian-Ming Wang",
                "org": ""
            },
            {
                "name": "Xin Wang",
                "org": ""
            },
            {
                "name": "Ya-Hong Yu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Ming Shen",
                "org": ""
            },
            {
                "name": "Zhi-Qiang Ding",
                "org": ""
            },
            {
                "name": "Ren-Ri Qin",
                "org": ""
            },
            {
                "name": "Sheng-Quan Zou",
                "org": ""
            },
            {
                "name": "Jia-Qin Qian",
                "org": ""
            }
        ],
        "title": "Effects of postoperative enteral immune-enhancing nutrients on plasma endotoxin level, plasma endotoxin inactivation capacity and clinical prognosis",
        "abstract": "AIM: To investigate the effects of immune-enhancing nutrients such as glutamine, arginine and \u03c9-3-fatty acid on the plasma endotoxin, plasma sCD14, plasma endotoxin inactivation capacity and clinical prognosis of patients received gastrointestinal operations. METHODS: Forty patients received gastrointestinal operations were randomly divided into two groups (20 for each). One group received standard enteral nutrition and the other was fed the standard formulation supplemented with glutamine, arginine and \u03c9-3-fatty acid. One day after the operation, the patients were administered with the above nutrients that contained equal energy and equal amount of nitrogen for 7 days. Blood samples were collected 1 day before the operation and 1, 4 and 7 days after the operation for the detection of plasma endotoxin level and endotoxin inactivation capacity (EIC). The infection-associated complications and the prognosis were also evaluated. RESULTS: There were no significant differences between the two groups in plasma endotoxin levels and the infection-associated complications. After the operation, a rapid reduction in plasma endotoxin inactivation capacity was observed in both groups, but a significant restoration the plasma endotoxin inactivation capacity was observed 4 days after the operation in the study group (0.12 \u00b1 0.02 kEU/L and 0.078 \u00b1 0.022 kEU/L for the control and study group, respectively, P<0.01). Shortened hospital stay was observed in the study group (11.7 \u00b1 2.0 and 10.6 \u00b1 1.2 days in the control study group, respectively, P<0.05). CONCLUSION: Perioperative parenteral nutrition supplemented with immune-enhancing nutrients can ameliorate the postoperative immunodepression, but it has no significant effect on endotoxemia.",
        "keywords": [
            "Endotoxin",
            "Endotoxin inactivation",
            "Gastrointestinal operation",
            "Immune-enhancing nutrients",
            "Prognosis"
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2005,
        "id": "3WhrX9AF"
    },
    "HotdEeGx": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Ping Zhang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Yan-Fa Meng",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Fei Xu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Da-Wei Zhang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Jian Cheng",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Hong-Hui Lin",
                "org": "State Key Laboratory of Hydraulics and Mountain River Engineering"
            },
            {
                "name": "De-Hui Xi",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            }
        ],
        "title": "Alpha-momorcharin, a RIP produced by bitter melon, enhances defense response in tobacco plants against diverse plant viruses and shows antifungal activity in vitro",
        "abstract": "Alpha-momorcharin (\u03b1-MMC) is type-1 ribosome inactivating proteins (RIPs) with molecular weight of 29 kDa and has lots of biological activity. Our recent study indicated that the \u03b1-MMC purified from seeds of Momordica charantia exhibited distinct antiviral and antifungal activity. Tobacco plants pre-treated with 0. 5 mg/mL \u03b1-MMC 3 days before inoculation with various viruses showed less-severe symptom and less reactive oxygen species (ROS) accumulation compared to that inoculated with viruses only. Quantitative real-time PCR analysis revealed that the replication levels of viruses were lower in the plants treated with the \u03b1-MMC than control plants at 15 days post inoculation. Moreover, the coat protein expression of viruses was almost completely inhibited in plants which were treated with the \u03b1-MMC compared with control plants. Furthermore, the SA-responsive defense-related genes including non-expressor of pathogenesis-related genes 1 (NPR1), PR1, PR2 were up-regulated and activities of some antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) were increased after the \u03b1-MMC treatment. In addition, the \u03b1-MMC (500 \u03bcg/mL) revealed remarkable antifungal effect against phytopathogenic fungi, in the growth inhibition range 50. 35-67. 21 %, along with their MIC values ranging from 100 to 500 \u03bcg/mL. The \u03b1-MMC had also a strong detrimental effect on spore germination of all the tested plant pathogens along with concentration as well as time-dependent kinetic inhibition of Sclerotinia sclerotiorum. The \u03b1-MMC showed a remarkable antiviral and antifungal effect and hence could possibly be exploited in crop protection for controlling certain important plant diseases. \u00a9 2012 Springer-Verlag.",
        "keywords": [
            "\u03b1-Momorcharin",
            "Antifungal activity",
            "Antiviral",
            "Reactive oxygen species (ROS)",
            "Ribosome inactivating proteins (RIPs)",
            "Virus replication"
        ],
        "venue": "Planta",
        "year": 2013,
        "id": "HotdEeGx"
    },
    "7ZHsjymx": {
        "authors": [
            {
                "name": "Shao-Dong Wang",
                "org": "Plant Pathology Laboratory, College of Life Science"
            },
            {
                "name": "Feng Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Shu Yuan",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Hui Yang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Fei Xu",
                "org": "Plant Pathology Laboratory, College of Life Science"
            },
            {
                "name": "Jing Shang",
                "org": "Plant Pathology Laboratory, College of Life Science"
            },
            {
                "name": "Mo-Yun Xu",
                "org": "Plant Pathology Laboratory, College of Life Science"
            },
            {
                "name": "Shu-Dan Jia",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Zhong-Wei Zhang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Jian-Hui Wang",
                "org": "Horticulture Institute"
            },
            {
                "name": "De-Hui Xi",
                "org": "Plant Pathology Laboratory, College of Life Science"
            },
            {
                "name": "Hong-Hui Lin",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            }
        ],
        "title": "The roles of ascorbic acid and glutathione in symptom alleviation to SA-deficient plants infected with RNA viruses",
        "abstract": "Salicylic acid (SA) is required for plant systemic acquired resistance (SAR) to viruses. However, SA-deficient plants adapt to RNA virus infections better, which show a lighter symptom and have less reactive oxygen species (ROS) accumulation. The virus replication levels are higher in the SA-deficient plants during the first 10 days, but lower than the wild-type seedlings after 20 dpi. The higher level of glutathione and ascorbic acid (AsA) in SA-deficient plants may contribute to their alleviated symptoms. Solo virus-control method for mortal viruses results in necrosis and chlorosis, no matter what level of virus RNAs would accumulate. Contrastingly, early and high-dose AsA treatment alleviates the symptom, and eventually inhibits virus replication after 20 days. ROS eliminators could not imitate the effect of AsA, and could neither alleviate symptom nor inhibit virus replication. It suggests that both symptom alleviation and virus replication control should be considered for plant virus cures. \u00a9 2011 Springer-Verlag.",
        "keywords": [
            "Ascorbic acid",
            "Cell death",
            "Salicylic acid",
            "Symptom alleviation",
            "Virus replication"
        ],
        "venue": "Planta",
        "year": 2011,
        "id": "7ZHsjymx"
    },
    "O9wPLVca": {
        "authors": [
            {
                "name": "Zhong-Wei Zhang",
                "org": ""
            },
            {
                "name": "Ling-Yang Feng",
                "org": ""
            },
            {
                "name": "Jian Cheng",
                "org": ""
            },
            {
                "name": "He Tang",
                "org": ""
            },
            {
                "name": "Fei Xu",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Zhong-Yi Zhao",
                "org": ""
            },
            {
                "name": "Ming Yuan",
                "org": ""
            },
            {
                "name": "Yang-Er Chen",
                "org": ""
            },
            {
                "name": "Jian-Hui Wang",
                "org": ""
            },
            {
                "name": "Shu Yuan",
                "org": ""
            },
            {
                "name": "Hong-Hui Lin",
                "org": ""
            }
        ],
        "title": "The roles of two transcription factors, ABI4 and CBFA, in ABA and plastid signalling and stress responses",
        "abstract": "Genetic and physiological studies have revealed evidences for multiple signaling pathways by which the plastid exerts retrograde control over photosynthesis-associated-nuclear-genes. In this study we have examined the mechanisms of control of transcription by plastid signals, focusing on transcription factors. We have also further addressed the physical nature of plastid signals and the physiological role, in stress acclimation of this regulatory pathway. ABI4, a master Apetala 2 (AP2)-type transcription factor (TF), is targeted by multiple signalling pathways in plant cells, such as abscisic acid (ABA) signals, sugar signals and plastid signals derived from reactive oxygen species (ROS) and chlorophyll intermediates. ABI4 binds the promoter of target genes to prevent their transcription by competing with other competitive TFs. However, we found that once ABI4 bound the element (CCACGT), it may not be bound by other TFs, therefore making the signalling long-lasting. Downstream of ABI4, CBFA (CCAAT binding factor A) is a subunit of the HAP2/HAP3/HAP5 (Heme activator protein) trimeric transcription complex. CBFA however is a redundant HAP3 subunit. When emergency occurs (such as herbicide treatments or environmental stresses followed by ABA and ROS accumulation), the master transcription factor ABI4 down-regulates some TFs, like CBFA, and then some other TF subunits enter the transcription complex and transcriptional efficiency of stress-responsive genes (including the transcription co-factor CBP) is improved instantaneously. abi4, cbfA and cbp mutants showed weaker drought-tolerance after a herbicide norflurazon treatment, which indicated the physiological role of these key transcription factors. \u00a9 2013 Springer Science+Business Media Dordrecht.",
        "keywords": [
            "ABI4",
            "CBFA",
            "GUN1",
            "Plastid signaling",
            "Tetrapyrroles",
            "Transcription factor"
        ],
        "venue": "Plant Molecular Biology",
        "year": 2013,
        "id": "O9wPLVca"
    },
    "aQj7HgKB": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Institute of Cardiology"
            },
            {
                "name": "Yu-Hua Liao",
                "org": "Institute of Cardiology"
            }
        ],
        "title": "Therapeutic renin-angiotensin vaccines for the treatment of hypertension",
        "abstract": "Hypertension is a pathophysiological state of persistently high bldod pressure and is a major risk factor for stroke, coronary heart disease, heart failure, renal failure and arterial aneurysm. Despite recent success in the use of traditional chemical drugs for the management of hypertension, the incidence of this condition is on the rise and has reached epidemic proportions by all estimates. A new class of therapies targeting the renin-angiotensin system (RAS) based on vaccine approaches are now in clinical trials and hold promise for the long-term control of hypertension. ln this review, we discuss the role of the RAS in hypertension, the different RAS components as targets for vaccination, the efficient and safe immune response to self-antigens in the RAS vaccine, and the future of RAS vaccines. Copyright 2008 Prous Science S.A.U. or its licensors. All right reserved.",
        "keywords": [
            ""
        ],
        "venue": "Drugs of the Future",
        "year": 2008,
        "id": "aQj7HgKB"
    },
    "Zq8ksr5I": {
        "authors": [
            {
                "name": "Shoufeng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zhaolong Ma",
                "org": "Spine Surgery"
            },
            {
                "name": "Caiwei Xia",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Histologic, risser sign, and digital skeletal age evaluation for residual spine growth potential in Chinese female idiopathic scoliosis",
        "abstract": "STUDY DESIGN. A prospective study. OBJECTIVE. To ascertain the correlation between histologic grades (HGs) of vertebral growth plates and Risser grades as well as DSA stages in the Chinese female idiopathic scoliosis (IS) patients; to identify whether digital skeletal age (DSA) is a reliable indicator for accurate evaluation of the spinal residual growth potential. SUMMARY OF BACKGROUND DATA. DSA is considered one of the more important indicators for representing the peak height velocity (PHV) typically and predicting spinal growth potential. The correlation between HGs of growth plates and DSA stages in IS patients is unclear. METHODS. Thirty-nine Chinese female patients were available for this study. Superior and inferior growth plates were obtained at each level when anterior approach surgeries were performed. Histologic examinations were conducted after the specimens were processed. Of these patients, 28 cases were evaluated by DSA stages in this study. Correlations between histologic grades, Risser grades, menarchal status, and chronologic age were analyzed in 39 patients. Correlations between histologic grades, DSA, menarchal status, and chronologic age were analyzed in 28 patients. RESULTS. There was a negative correlation between the following: HGs and Risser grades in 39 patients (r = -0.645, P = 0.000-0.05), HGs and menarchal status in patients in Risser 4 (r = -0.710, P = 0.002-0.05), HGs and DSA stages in 28 cases (r = -0.541, P = 0.003-0.05), and HGs and menarchal status in patients in DSA Stage III (r = -0.591, P = 0.006-0.05). Statistical significance of growth activity of growth plates was found between patients in Risser Grades 0 to 1 and those in Risser Grades 2 to 5 (P = 0.020-0.05) and patients in DSA Stage II and those in DSA Stage III (P = 0.014-0.05). CONCLUSION. DSA may be a reliable indicator for predicting the spinal residual growth potential in IS patients, but it should be correlated with menarchal status and chronologic ages. \u00a9 2007 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Digital skeletal age",
            "Histology",
            "Idiopathic scoliosis",
            "Risser sign"
        ],
        "venue": "Spine",
        "year": 2007,
        "id": "Zq8ksr5I"
    },
    "lyPsTLe4": {
        "authors": [
            {
                "name": "Guang-Hua Guo",
                "org": "Department of Critical Care Medicine"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Critical Care Medicine"
            }
        ],
        "title": "Establishment and management of a burn ICU",
        "abstract": "This paper elaborates systemically the establishment and management of a burn ICU, and also the theory and technology related to shock resuscitation, respiratory support, infection, blood purification, nutritional support, cardiopulmonary resuscitation, sedation and analgesia, etc. from the perspective of critical care medicine. The relevant guidelines and recommendations are introduced in order to provide some guidance and help for the establishment of a burn ICU.",
        "keywords": [
            "Burns",
            "Critical care medicine",
            "Intensive care units"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2013,
        "id": "lyPsTLe4"
    },
    "709Zz1MQ": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "De-Hui Xi",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Shu Yuan",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Fei Xu",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Da-Wei Zhang",
                "org": "Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science"
            },
            {
                "name": "Hong-Hui Lin",
                "org": "State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University"
            }
        ],
        "title": "Salicylic acid and jasmonic acid are essential for systemic resistance against tobacco mosaic virus in nicotiana benthamiana",
        "abstract": "Systemic resistance is induced by pathogens and confers protection against a broad range of pathogens. Recent studies have indicated that salicylic acid (SA) derivative methyl salicylate (MeSA) serves as a long-distance phloemmobile systemic resistance signal in tobacco, Arabidopsis, and potato. However, other experiments indicate that jasmonic acid (JA) is a critical mobile signal. Here, we present evidence suggesting both MeSA and methyl jasmonate (MeJA) are essential for systemic resistance against Tobacco mosaic virus (TMV), possibly acting as the initiating signals for systemic resistance. Foliar application of JA followed by SA triggered the strongest systemic resistance against TMV. Furthermore, we use a virus-induced gene-silencing- based genetics approach to investigate the function of JA and SA biosynthesis or signaling genes in systemic response against TMV infection. Silencing of SA or JA biosynthetic and signaling genes in Nicotiana benthamiana plants increased susceptibility to TMV. Genetic experiments also proved the irreplaceable roles of MeSA and MeJA in systemic resistance response. Systemic resistance was compromised when SA methyl transferase or JA carboxyl methyltransferase, which are required for MeSA and MeJA formation, respectively, were silenced. Moreover, high-performance liquid chromatography-mass spectrometry analysis indicated that JA and MeJA accumulated in phloem exudates of leaves at early stages and SA and MeSA accumulated at later stages, after TMV infection. Our data also indicated that JA and MeJA could regulate MeSA and SA production. Taken together, our results demonstrate that (Me)JA and (Me)SA are required for systemic resistance response against TMV. \u00a9 2014 The American Phytopathological Society.",
        "keywords": [
            ""
        ],
        "venue": "Molecular Plant-Microbe Interactions",
        "year": 2014,
        "id": "709Zz1MQ"
    },
    "67fq2CXA": {
        "authors": [
            {
                "name": "Zhi-Wei Wang",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Wei-Jun Wang",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Ming-Hui Sun",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Zhen Liu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Ze-Zhang Zhu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Xu-Sheng Qiu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Bang-Ping Qian",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Shou-Feng Wang",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            },
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School"
            }
        ],
        "title": "Characteristics of the pelvic axial rotation in adolescent idiopathic scoliosis: A comparison between major thoracic curve and major thoracolumbar/lumbar curve",
        "abstract": "Background context As the biomechanical foundation of the spine, the pelvis was found to display rotation in the transverse plane in adolescent idiopathic scoliosis (AIS). However, the possible factors influencing the pelvic axial rotation (PAR) and its mechanism in patients with AIS remain unclear. Purpose To characterize the PAR in AIS patients with right major thoracic (MT) or major left thoracolumbar/lumbar (TL/L) curve and to explore the associated influencing factors and probable mechanism of compensation by analyzing the association between PAR and other spinal radiographic parameters. Study design Retrospective study. Patient sample All patients with the primary diagnosis of AIS from January 2008 to November 2009 were retrieved from our scoliosis database. Outcome measures Age, Cobb angle, and apex rotation of the main curve and the compensatory curve, curve flexibility, and PAR. Methods One-hundred thirty-two patients with right MT (14.7\u00b11.8 years, 48\u00b16.9\u00b0) and 83 patients with left major TL/L (14.7\u00b11.5 years, 46\u00b16.6\u00b0) were retrospectively reviewed. On standing full-spine posteroanterior radiographs, the PAR was quantified by the left/right hemi-pelvis width ratio (L/R ratio); then the subjects in both MT and major TL/L groups were divided into two subgroups: L/R ratio \u22641 (pelvis rotated to the right, R-PAR group); and L/R ratio >1 (pelvis rotated to the left, L-PAR group). Comparisons of all variables were performed between the L- and R-PAR subgroups; correlation and regression analysis were carried out to identify the influencing factors of PAR. Results The majority of the MT and major TL/L patients (75.8% vs. 60.2%) displayed right pelvic rotation, which was in the same direction as the thoracic curve. The incidence of R-PAR was greater in the MT patients than the major TL/L ones (p=.016). Lumbar flexibility in MT patients with R-PAR was greater than in MT patients with L-PAR (0.96\u00b10.27 vs. 0.81\u00b10.33, p=.038), which was contrary to the findings in the major TL/L patients (L-PAR>R-PAR, 0.79\u00b10.15 vs. 0.70 \u00b10.22, p=.024). In the MT patients with R-PAR, the L/R ratio showed significant positive correlations with the lumbar Cobb angle (r=0.424) as well as with the apex rotation (r=0.488), which was further identified as an influencing factor (R=0.418) of the PAR. Significant positive correlations between L/R ratio and thoracic apex rotation (r=0.361) also were detected. Conclusion The majority of AIS patients with right MT or left major TL/L curves were found to have PAR to the right, in the same direction as the thoracic curve. The lumbar flexibility and apex rotation significantly influenced the PAR direction and magnitude. Moreover, the pelvis might be involved in compensation for the MT deformity through its connection with the lumbar spine. \u00a9 2014 Elsevier Inc. All rights reserved.",
        "keywords": [
            "Adolescent",
            "Idiopathic scoliosis",
            "Influencing factor",
            "Lumbar flexibility",
            "Pelvic rotation",
            "Pelvis",
            "Transverse plane"
        ],
        "venue": "Spine Journal",
        "year": 2014,
        "id": "67fq2CXA"
    },
    "OrvO3Aug": {
        "authors": [
            {
                "name": "Qianyu Zhang",
                "org": ""
            },
            {
                "name": "Na He",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Qiuxia Chen",
                "org": ""
            },
            {
                "name": "Yao Qin",
                "org": ""
            },
            {
                "name": "Zhirong Zhang",
                "org": ""
            },
            {
                "name": "Qiang Zhang",
                "org": ""
            },
            {
                "name": "Shuang Wang",
                "org": ""
            },
            {
                "name": "Qin He",
                "org": ""
            }
        ],
        "title": "The in vitro and in vivo study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) based on insulin-phospholipid complex",
        "abstract": "Self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of insulin after oral administration, where insulin was complexed with phospholipid to achieve a better liposolubility in the form of insulin-phospholipid complex (IPC). IPC was formulated into the oil phase of SNEDDS by solvent-evaporation method. The formula of IPC-SNEDDS was optimized and characterized. Data showed that SNEDDS as a drug vehicle did not exhibit an obvious inhibition over MDCK cells, and it can facilitate the transport of IPC across MDCK cell monolayer. IPCSNEDDS could enhance the absorption of insulin after oral administration and yielded a pronounced hypoglycemic effect on diabetic Wistar rats. All these suggested that IPC-SNEDDS has a great potential for oral delivery of insulin. Copyright \u00a9 2012 American Scientific Publishers All rights reserved.",
        "keywords": [
            "Diabetic models",
            "Enhanced oral absorption",
            "Insulin-Phospholipid Complex (IPC)",
            "MDCK monolayer",
            "Self-Nanoemulsifying Drug Delivery Systems (SNEDDS)"
        ],
        "venue": "Journal of Biomedical Nanotechnology",
        "year": 2012,
        "id": "OrvO3Aug"
    },
    "rveGYfxj": {
        "authors": [
            {
                "name": "Zhan-Jun Lu",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Lun-Gen Lu",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Kai-Zhong Tao",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Da-Fan Chen",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Qing Xia",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Jian Jun Weng",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Feng Zhu",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Xing-Peng Wang",
                "org": "Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine"
            },
            {
                "name": "Ping Zheng",
                "org": "Department of Gastroenterology, Shanghai East Hospital Affiliated to Tongji University"
            }
        ],
        "title": "MicroRNA-185 suppresses growth and invasion of colon cancer cells through inhibition of the hypoxiainducible factor-2\u03b1 pathway in vitro and in vivo",
        "abstract": "MicroRNAs (miRs) are small noncoding RNAs with regulatory roles, which are involved in a broad spectrum of physiological and pathological processes, including cancer development and progression. However, the function of miR185 in the development of human colon cancer has not yet been investigated. In this study, the association between miR185 expression and the clinicopathological characteristics of patients with colon cancer was analyzed using quantitative polymerase chain reaction (qPCR). Using a gainoffunction approach, the effects of miR185 overexpression on the expression of hypoxiainducible factor2\u03b1 (HIF2\u03b1), proliferating cell nuclear antigen (PCNA) and matrix metallopeptidase2 (MMP2) were investigated in SW620 colon cancer cells using qPCR and western blotting. Functional analysis of cellular proliferative activities, by MTT assay, and invasive potential, by Transwell assay, was conducted on SW620 cells expressing low levels of miR185. miR185 was found to be significantly downregulated in cancer tissues compared with adjacent noncancerous tissues, and was negatively correlated with lymph node metastasis of colon cancer (P<0.001). miR185 overexpression in vitro impeded cellular proliferation and invasive potential with reduced expression of HIF2\u03b1, PCNA and MMP2 in SW620 cells transfected with an miR185 mimic. In addition, the tumor volumes in SW620 subcutaneous nude mouse models treated with miR185 were significantly smaller than those of the control group. In conclusion, these findings indicate that miR185 as a tumor suppressor may affect the development of colon cancer cells via inhibition of HIF2\u03b1 signaling, suggesting that miR185 may serve as a potential therapeutic target in cancer treatment.",
        "keywords": [
            "Colon cancer",
            "Hypoxiainducible factor-2\u03b1",
            "Invasion",
            "Microrna-185",
            "Proliferation"
        ],
        "venue": "Molecular Medicine Reports",
        "year": 2014,
        "id": "rveGYfxj"
    },
    "9DGZO2cM": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Medical School"
            },
            {
                "name": "Feng Zhu",
                "org": "Medical School"
            },
            {
                "name": "Bin Wang",
                "org": "Medical School"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Medical School"
            },
            {
                "name": "Yang Yu",
                "org": "Medical School"
            },
            {
                "name": "Xu Sun",
                "org": "Medical School"
            },
            {
                "name": "Weiwei Ma",
                "org": "Medical School"
            }
        ],
        "title": "Mini-open anterior instrumentation with diaphragm sparing for thoracolumbar idiopathic scoliosis: Its technique and clinical results",
        "abstract": "The traditional method of thoracoabdominal retroperitoneal approach requires dissection of diaphragm which bears potential complications such as postoperatively weakened abdominal breathing and dysfunction of diaphragm. Mini-open anterior instrumentation with diaphragm sparing is designed to minimize the damage to diaphragm and improve cosmesis. This study compared the traditional anterior instrumentation and mini-open anterior instrumentation under the hypothesis that both results in similar surgical outcomes in treating thoracolumbar scoliosis. In Group A, 38 patients with an average age of 16.5 years underwent mini-open anterior instrumentation with diaphragm sparing. The average standing coronal Cobb angle was 56.4\u00b0 in Group A. Thirty-eight patients with average age of 16.7 years in Group B received traditional open approach. The preoperative average Cobb angle was 55.8\u00b0 in Group B. The average correction rate of coronal curve was 78% in group A while 75% in group B. No statistical difference between the two groups in terms of coronal curve correction, sagittal profile restoration and estimated blood loss was observed. The operation time was significantly higher in Group A than that in Group B. All patients in the two groups had good healing of incisions without neurological and instrumental complications during minimal 2 year follow-up. In Groups A and B, two patients suffered from pleural effusion, respectively. The wedging of the vertebral discs distal to the lowest fused level occurred in three and four patients in Group A and B, respectively. One case in group B was found to be suspicious pseudoarthrosis without loss of correction. Mini-open anterior instrumentation with diaphragm sparing could minimize the surgical invasion as well as achieve similar clinical outcomes compared with classical anterior approach. \u00a9 Springer-Verlag 2010.",
        "keywords": [
            "Anterior instrumentation",
            "Diaphragm",
            "Minimal invasive",
            "Scoliosis",
            "Thoracolumbar"
        ],
        "venue": "European Spine Journal",
        "year": 2011,
        "id": "9DGZO2cM"
    },
    "oGWrTEZh": {
        "authors": [
            {
                "name": "Yong Qiu",
                "org": "Spine Surgery"
            },
            {
                "name": "Shoufeng Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Bin Wang",
                "org": "Spine Surgery"
            },
            {
                "name": "Yang Yu",
                "org": "Spine Surgery"
            },
            {
                "name": "Feng Zhu",
                "org": "Spine Surgery"
            },
            {
                "name": "Zezhang Zhu",
                "org": "Spine Surgery"
            }
        ],
        "title": "Incidence and risk factors of neurological deficits of surgical correction for scoliosis: Analysis of 1373 cases at one Chinese institution",
        "abstract": "STUDY DESIGN. A retrospective study. OBJECTIVE. To investigate the incidence of neurologic deficits after scoliosis correction at 1 institution and identify the risk factors for such deficits in scoliosis correction. SUMMARY OF BACKGROUND DATA. Neurologic deficit is one of the risks of surgical correction of scoliosis. Reports of the incidence of the neurologic deficits involving a large number of cases at 1 institution are rare. METHODS. Statistical analysis of the neurologic deficits was performed in 1373 scoliosis cases treated at 1 institution by etiologies in light of the patients' sex, age, sagittal profile, surgical approach, Cobb's angle, and the type of surgery. RESULTS. The total incidence of neurologic deficits was 1.89% and that of serious and mild ones was 0.51% and 1.38%, respectively. The total incidence of neurologic deficits were 1.06% in adolescent idiopathic scoliosis patients and 2.89% in congenital scoliosis (CS) patients, 3.32% in scoliosis patients with hyperkyphosis (>40\u00b0) and 1.38% in those without hyperkyphosis, 3.43% for combined procedures and 1.24% for single posterior procedures, 3.69% in patients with Cobb's angle more than 90\u00b0 and 1.45% in those with an angle less than 90\u00b0, 1.68% with primary surgery and 5.97% with revision surgery, the difference between them was significant (P < 0.05). In adolescent idiopathic scoliosis patients, the incidence were 3.85% for combined procedures and 0.64% for posterior procedure, 0.82% with primary surgery and 8.33% with revision surgery, 4.17% with hyperkyphosis and 0.61% without hyperkyphosis, the difference between them was significant (P < 0.05). The incidence of CS patients with Cobb's angle more or less than 90\u00b0 were 7.23% and 1.68% and the difference was significant (P < 0.05). CONCLUSION. In surgical correction of scoliosis, the risk factors for neurologic deficits include CS, scoliosis with hyperkyphosis, scoliosis correction by combined procedures, scoliosis with a Cobb's angle more than 90\u00b0, and a revision surgery. \u00a9 2008 Lippincott Williams & Wilkins, Inc.",
        "keywords": [
            "Incidence",
            "Neurologic deficits",
            "Risk factors",
            "Scoliosis"
        ],
        "venue": "Spine",
        "year": 2008,
        "id": "oGWrTEZh"
    },
    "uGfGNoXC": {
        "authors": [
            {
                "name": "Shoufeng Wang",
                "org": ""
            },
            {
                "name": "Yong Qiu",
                "org": ""
            },
            {
                "name": "Wenjun Liu",
                "org": ""
            },
            {
                "name": "Benlong Shi",
                "org": ""
            },
            {
                "name": "Bin Wang",
                "org": ""
            },
            {
                "name": "Yang Yu",
                "org": ""
            },
            {
                "name": "Zezhang Zhu",
                "org": ""
            },
            {
                "name": "Bangping Qian",
                "org": ""
            },
            {
                "name": "Feng Zhu",
                "org": ""
            },
            {
                "name": "Xu Sun",
                "org": ""
            }
        ],
        "title": "The potential risk of spinal cord injury from pedicle screw at the apex of adolescent idiopathic thoracic scoliosis: magnetic resonance imaging evaluation Orthopedics and biomechanics",
        "abstract": "Background: The pedicle screw placement in scoliosis correction at the apex underlies potential risk for neurological injury. This research is to investigate the relative position of spinal cord at the apex in idiopathic thoracic scoliosis and to explore the risk of spinal cord injury from pedicle screw at the apex. Methods: Thirty-three adolescents with thoracic scoliosis were recruited in this study. The relative position of the spinal cord in the spinal canal was calculated by measuring the distance between the spinal cord and the medial wall of the pedicle on the convex and concave side through the axial plane of the apex in T2 weighted MR image. The distance from the spinal cord to the medial wall of pedicle between concave and convex side was compared respectively. The percentage of patients was calculated according to hypothesized different space (0 mm, less than 1 mm and less than 2 mm) between medial wall of pedicle and spinal cord at the apex. Results: The average distance from the spinal cord to the medial wall of pedicle at the concave side was significantly less than that at the convex side (p = 0.000) of the apex in the major thoracic curves before operation. In the concave side of the apex, the percentage of patients was 39.4, 66.7, 84. 5 % in hypothesized space (0 mm, less than 1 mm and less than 2 mm) between medial wall of pedicle and spinal cord. However, in the convex side of apex, the percentage of cases was 0, 0, 3.0 % in the same hypothesized space respectively. Conclusions: The screw placement is at a higher risk of spinal cord injury on the concave side than that on the convex side of apex in thoracic curve in MRI images. The screw placement in the concave side of apex should be evaluated carefully with MRI before operation.",
        "keywords": [
            "Apex",
            "Pedicle screw",
            "Risk",
            "Scoliosis correction",
            "Spinal cord injury"
        ],
        "venue": "BMC Musculoskeletal Disorders",
        "year": 2015,
        "id": "uGfGNoXC"
    },
    "8TFHq7dq": {
        "authors": [
            {
                "name": "Can Li",
                "org": "EastChina Power Info. Tech. Eng. Co."
            },
            {
                "name": "Feng Zhu",
                "org": "East China Grid Co."
            },
            {
                "name": "Libing Yang",
                "org": "East China Grid Co."
            },
            {
                "name": "Bin Fan",
                "org": "North China Elec. Power Univ."
            },
            {
                "name": "Lei He",
                "org": "EastChina Power Info. Tech. Eng. Co."
            },
            {
                "name": "Zhongwei Wu",
                "org": "EastChina Power Info. Tech. Eng. Co."
            }
        ],
        "title": "Monthly ahead two-way bidding mode for the East China Electricity Market",
        "abstract": "This paper describes the monthly ahead two-way bidding mode for the East China Electricity Market. A relevant mathematical model is established. Based on the results of actual cases of the East China Electricity Market, the characteristics of this mode are analyzed. The transaction in the market reveal that monthly ahead two-way bidding mode is easy to implement and effective to utilize the power of market to allocate resources. The significance and the rationality of the mode, including the background from which the mode is originated, are discussed. And it is pointed out that under the situation of power supply deficient, the long period and large-scale transaction is in favor of keeping the electricity market stable. Moreover, some solutions to the issues in the design process of the mode, such as the way of bidding, the corresponding contract of the bidding or offering results, are also provided.",
        "keywords": [
            "Electricity market",
            "Linear programming",
            "Monthly ahead bidding"
        ],
        "venue": "Dianli Xitong Zidonghua/Automation of Electric Power Systems",
        "year": 2004,
        "id": "8TFHq7dq"
    },
    "jLn4nkSL": {
        "authors": [
            {
                "name": "Lixia Li",
                "org": "School of Resources and Civil Engineering"
            },
            {
                "name": "Xiao Liu",
                "org": "Sinosteel Maanshan Institute of Mining Research Co., Ltd."
            },
            {
                "name": "Yuexin Han",
                "org": "School of Resources and Civil Engineering"
            },
            {
                "name": "Qidong Yuan",
                "org": "Sinosteel Maanshan Institute of Mining Research Co., Ltd."
            },
            {
                "name": "Ningbo Song",
                "org": "MCC Capital Engineering and Research Incorporation Qinhuangdao Co, Ltd."
            }
        ],
        "title": "Research on desulphurization and skimming slag tailing used as building materials",
        "abstract": "With the purpose that the desulphurization and skimming slag tailings from Ansteel can be used as building materials, the slag tailings were ground to powders with specific surface area 560m",
        "keywords": [
            "Cement",
            "Compressive strength",
            "Concrete",
            "Desulphurization and skimming slag tailing"
        ],
        "venue": "Advanced Materials Research",
        "year": 2011,
        "id": "jLn4nkSL"
    },
    "HkedlRqa": {
        "id": "HkedlRqa",
        "title": "Analysis of Effects of Separation of Revenue and Expenditure Budgets Implemented in Community Health Service Institutions",
        "authors": [
            {
                "name": "ZHANG Tong",
                "org": " National center for women and Children\u2019s Health, China CDC, , China"
            },
            {
                "name": "HUANG Ying-chun",
                "org": " National center for women and Children\u2019s Health, China CDC, , China"
            }
        ],
        "venue": "chinese health economics",
        "keywords": [
            "CHS institutions",
            "effects",
            "SREB"
        ],
        "year": 2009
    },
    "vN27fN0i": {
        "id": "vN27fN0i",
        "title": "Condom use among reproductive aged population and its influence factors",
        "authors": [
            {
                "name": "GUO Sufang",
                "org": "Beijing ,China"
            },
            {
                "name": "ZHAO Fengmin",
                "org": "Beijing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Beijing ,China"
            }
        ],
        "venue": "chinese journal of public health",
        "keywords": [
            "reproductive aged population",
            "condom",
            "influence factor"
        ],
        "year": 2006
    },
    "CPMrCQS2": {
        "id": "CPMrCQS2",
        "title": "Analysis on influence factors of antenatal care in reproductive aged women of various period",
        "authors": [
            {
                "name": "ZHAO Fengmin",
                "org": "Beijing ,China"
            },
            {
                "name": "GUO Sufang",
                "org": "Beijing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Beijing ,China"
            }
        ],
        "venue": "chinese journal of public health",
        "keywords": [
            "trend",
            "antenatal care",
            "influence factor"
        ],
        "year": 2006
    },
    "xhERMRVN": {
        "id": "xhERMRVN",
        "title": "Survey on condom use and persistence among currently married men",
        "authors": [
            {
                "name": "ZHAO Fengmin",
                "org": "Beijing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": "Beijing ,China"
            },
            {
                "name": "GUO Sufang",
                "org": "Beijing ,China"
            }
        ],
        "venue": "chinese journal of public health",
        "keywords": [
            "persistence",
            "condom",
            "currently married men"
        ],
        "year": 2006
    },
    "0ipPUSmw": {
        "id": "0ipPUSmw",
        "title": "Survey on contraception and persistence among currently married women",
        "authors": [
            {
                "name": "ZHAO Feng-Min",
                "org": ",et al.National Center for Women and Children Health,Chinese Center for Disease Control and Prevention,Beijing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": ",et al.National Center for Women and Children Health,Chinese Center for Disease Control and Prevention,Beijing ,China"
            },
            {
                "name": "WU Jiu-Ling",
                "org": ",et al.National Center for Women and Children Health,Chinese Center for Disease Control and Prevention,Beijing ,China"
            }
        ],
        "venue": "maternal and child health care of china",
        "keywords": [
            "Persistence",
            "Satisfaction",
            "Married women",
            "Current contraceptive method"
        ],
        "year": 2007
    },
    "CG34Bwlo": {
        "id": "CG34Bwlo",
        "title": "Modeling for information statistics management system of women's and children's health based on Unified Modeling Language",
        "authors": [
            {
                "name": "WEI Tong",
                "org": ". National Center for Women and Children's Health,China CDC,Beijing ,China"
            },
            {
                "name": "PAN Xiao-ping",
                "org": ". National Center for Women and Children's Health,China CDC,Beijing ,China"
            },
            {
                "name": "TANG Xue-jun",
                "org": ". National Center for Women and Children's Health,China CDC,Beijing ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": ". National Center for Women and Children's Health,China CDC,Beijing ,China"
            }
        ],
        "venue": "chinese journal of women and children health",
        "keywords": [
            "Use case",
            "System of women's and children's health",
            "Unified Modeling Language (UML)",
            "Modeling"
        ],
        "year": 2010
    },
    "40q4Yw8s": {
        "id": "40q4Yw8s",
        "title": "Study on the perception of gender role and decision-making regarding family affairs among married women and its impact on the utilization of perinatal care]",
        "authors": [
            {
                "name": "ZHAO Feng-min",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            },
            {
                "name": "GUO Su-fang",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            },
            {
                "name": "WANG Lin-hong",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            },
            {
                "name": "ZHANG Tong",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            },
            {
                "name": "WU Jiu-ling",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            },
            {
                "name": "DU Yu-kai",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            },
            {
                "name": "FANG Wei-min",
                "org": " . National Centre for Women and Children ' s Health , Chinese Centre for Disease Control and Prevention , Beijing  ,China"
            }
        ],
        "venue": "zhonghua liu xing bing xue za zhi = zhonghua liuxingbingxue zazhi",
        "keywords": [
            "perinatal care utilization",
            "decision-making about family affairs",
            "perception of gender role"
        ],
        "year": 2006
    },
    "t1X5MsPq": {
        "id": "t1X5MsPq",
        "title": "Experimental study of burning rates of cardboard box fires near sea level and at high altitude",
        "abstract": "To study the difference of solid fuel fire characteristics at different altitudes, two series of fire experiments of cardboard boxes filled with shredded office paper were conducted separately in Lhasa (altitude: 3650 m; air pressure: 65 kPa) and Hefei (altitude: 24 m, air pressure: 100.8 kPa), using a specially designed igniter. The measured parameters in the experiments include mass loss and flame axis temperature. Fuel load quantity and configuration were varied in the experiments. The results of the study indicate a likelihood that an ignition will result in smoldering fire at the high altitude. There is also likelihood that incipient phase may occur before the onset of full flaming combustion regardless of the altitude. The fuel mass loss fraction of flaming fires was found to follow a simple form of correlation with time when normalized over the half fuel consumption time, which was found to be inversely proportional to four-third power of the ambient pressure. \u00a9 2012 The Combustion Institute. Published by Elsevier Inc. All rights reserved.",
        "keywords": [
            "Flaming",
            "Half fuel consumption time",
            "Incipient",
            "Low air pressure",
            "Oxygen density"
        ],
        "authors": [
            {
                "name": "Yi Niu",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Yaping He",
                "org": "University of Western Sydney(University of Western Sydney),,Australia"
            },
            {
                "name": "Xiaokang Hu",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Dechuang Zhou",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Chaohsin Lin",
                "org": "Boeing Corporation(Boeing Company ^),Chicago,United States"
            },
            {
                "name": "Joe Yin",
                "org": "Boeing (China) Co. Ltd.(Boeing (China) Co. Ltd.),Beijing,China"
            },
            {
                "name": "Wei Yao",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "Proceedings of the Combustion Institute",
        "year": 2013
    },
    "CRJPzCwX": {
        "id": "CRJPzCwX",
        "title": "Numerical modeling of liquid n-heptane pool fires based on heat feedback equilibrium",
        "abstract": "Liquid free burning pool fires usually could maintain at a steady burning rate under a certain environment. Due to that the burning rate and the heat feedback could reach a steady self-equilibrium state. Based on mathematical analysis of the equilibrium process, a new modeling approach of liquid pool fires was developed and validated by liquid n-heptane pool fire experimental data. The difference between actual heat feedback and sustainable heat feedback clearly reveal the positive feedback process towards the equilibrium mass burning rate, which is given when the difference is zero. From the modeling results, the heat feedback difference increases from zero at zero burning rate in the positive direction, then drops in the negative direction above a certain burning rate. The equilibrium mass burning rates were close to the experimentally measured values for the n-heptane pool fires under two different environmental pressures. Other flame characteristics, such as axial temperature, absorption coefficient and radiative heat flux were generally in good agreement with the available experimental measurements. The mathematical analysis and numerical modeling of the n-heptane pool fires improve the understanding of the interaction mechanism between liquid fuel evaporation and burning behaviors for free burning pool fires. \u00a9 2013 International Association for Fire Safety Science.",
        "keywords": [
            "heat feedback",
            "mass burning rate",
            "numerical modeling",
            "pool fire",
            "tibet"
        ],
        "authors": [
            {
                "name": "Wei Yao",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Jiusheng Yin",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Xiaokang Hu",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Hui Zhang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Procedia Engineering",
        "year": 2013
    },
    "A4q0L0tp": {
        "id": "A4q0L0tp",
        "title": "Numerical Simulation Study of Smoke Exhaust Efficiency in an Atrium",
        "abstract": "",
        "keywords": [
            "entrainment",
            "exhaust efficiency",
            "fire plume",
            "large eddy simulation",
            "smoke interface",
            "injury prevention",
            "suicide prevention",
            "ergonomics",
            "human factors",
            "numerical simulation",
            "occupational safety"
        ],
        "authors": [
            {
                "name": "Dechuang Zhou",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Yaping He",
                "org": ""
            }
        ],
        "venue": "Journal of Fire Protection Engineering",
        "year": 2010
    },
    "wx4jtpAK": {
        "id": "wx4jtpAK",
        "title": "Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro.",
        "abstract": "This study was conducted to observe the in vivo effect of 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) on embryo implantation in rats and its in vitro effect on cell adhesion.The anti-implantation efficacy of AEBSF in rats was determined by counting the number of visible implanted embryos on day 8 of pregnancy following intrauterine (5 mg and 10 mg AEBSF per horn) or tail vein (10 mg AEBSF per rat) administration on day 3 of pregnancy. The effects of AEBSF on cell adhesion were detected, respectively, by using the mouse blastocysts-endometrial cells or the human umbilical vein endothelial cells (HUVECs)-HeLa cells co-culture model. The alteration in protein secretion pattern of HUVECs and HeLa cells was detected by the proteome analysis.4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride showed an in vivo inhibitory effect on embryo implantation in rat. In vitro, AEBSF could disturb the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs. The treatment of AEBSF could alter the protein secretion pattern of co-cultured HUVEC-HeLa cells.4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride might be a potential leading compound for novel contraceptives, and its inhibitory effect on implantation might result from the interference in extracellular matrix remodeling process.",
        "keywords": [
            "aebsf",
            "embryo",
            "rat",
            "serine protease inhibitor",
            "implantation",
            "cell adhesion",
            "embryos"
        ],
        "authors": [
            {
                "name": "Ya-hong Jiang",
                "org": ""
            },
            {
                "name": "Yan Shi",
                "org": ""
            },
            {
                "name": "Ya-ping He",
                "org": ""
            },
            {
                "name": "Jing Du",
                "org": ""
            },
            {
                "name": "Run-sheng Li",
                "org": ""
            },
            {
                "name": "Hui-juan Shi",
                "org": ""
            },
            {
                "name": "Zhao-gui Sun",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "Contraception",
        "year": 2011
    },
    "OFUXATRs": {
        "id": "OFUXATRs",
        "title": "A moving object detection algorithm based on Learning Vector Quantization",
        "abstract": "A moving object detection algorithm based on Learning Vector Quantization (LVQ) is presented. By training samples, the threshold vector of extracting the moving objects has the self-adaptive ability. The input vector includes components of YCbCr color space and direction feature of Gray Level Co-occurrence Matrix (GLCM). These two features are integrated to the algorithm, which has the efficiency of inhibiting the disturbance of background brightness variation. Experiment results indicate that the moving objects can be extracted correctly by using the algorithm, even if the complex background has an acute brightness variation.",
        "keywords": [
            "Gray level c-occurrence matrix",
            "Learning vector quantization",
            "Moving object detection",
            "YCbCr"
        ],
        "authors": [
            {
                "name": "Shidong Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Dechuang Zhou",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "Guangdian Gongcheng/Opto-Electronic Engineering",
        "year": 2012
    },
    "vJ0YFpP5": {
        "id": "vJ0YFpP5",
        "title": "Three types of power-law distribution of forest fires in Japan",
        "abstract": "Study on the forest-fire distribution is not only a phenomenological insight of forest ecological dynamics, but also essential for developing forest-fire danger rating method and system. In this paper, three types of power-law characteristics of forest fires are investigated. The first one is the distribution of fire areas. The frequency\u2013area distribution is found obeying good power-law relation that is invariant with time. The second one is the distribution of fire intervals. It is indicated that the frequency\u2013interval distribution of forest fires in Japan is also accord with power law. What is the most interesting is that the frequency\u2013interval distribution is a power law with periodic change, different to that of frequency\u2013size distribution. The third one is the distribution of fire probability against population density. There is positive-exponent power-law relation between fire probability and population density. The results discussed in this paper are expected to promote the forest-fire danger rating method and are helpful to understand the ecological action of forest fires.",
        "keywords": [
            "fire danger rating",
            "forest-fire model",
            "power law",
            "forest fire",
            "self-organized criticality",
            "self organized criticality",
            "forest fire model",
            "population density",
            "power law distribution"
        ],
        "authors": [
            {
                "name": "Weiguo Song",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, Anhui 230026, PR China"
            },
            {
                "name": "Kohyu Satoh",
                "org": "National Research Institute of Fire and Disaster, Tokyo, Japan"
            },
            {
                "name": "Weicheng Fan",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, Anhui 230026, PR China"
            }
        ],
        "venue": "Ecological Modelling",
        "year": 2006
    },
    "7xMPKqpP": {
        "id": "7xMPKqpP",
        "title": "A swaying object detection algorithm",
        "abstract": "Moving object detection is a most important preliminary step in video analysis. Some moving objects such as spitting steam, fire and smoke have unique motion feature whose lower position keep basically unchanged and the upper position move back and forth. Based on this unique motion feature, a swaying object detection algorithm is presented in this paper. Firstly, fuzzy integral was adopted to integrate color features for extracting moving objects from video frames. Secondly, a swaying identification algorithm based on centroid calculation was used to distinguish the swaying object from other moving objects. Experiments show that the proposed method is effective to detect swaying object. \u00a9 2013 SPIE.",
        "keywords": [
            "centroid",
            "fuzzy integral",
            "moving object detection",
            "swaying object",
            "video"
        ],
        "authors": [
            {
                "name": "Shidong Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jianzhong Rong",
                "org": "Sichuan Fire Research Institute of Ministry of Public Security(Sichuan Fire Research Institute of Ministry of Pubic Security,Sichuan Fire Research Institute of Ministry of Public Security,Sichuan fire research institute of Ministry of Public Security),Chengdu,China"
            },
            {
                "name": "Dechuang Zhou",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "ICDIP",
        "year": 2013
    },
    "WVY4671l": {
        "id": "WVY4671l",
        "title": "Experimental study on the thermal behaviors of lithium-ion batteries under discharge and overcharge conditions",
        "abstract": "To have a better understanding of the thermal behaviors of lithium-ion batteries (LIBs) under discharge and overcharge conditions, some tests were conducted by a cone calorimeter. Several parameters were measured such as the battery surface temperature, voltage, the time to thermal runaway, the time to maximum temperature, heat release rate and total heat released. The results indicate that the lithium-ion battery will have obvious warming up during discharge owing to the reversible heat and irreversible heat. It was observed that the current treatment (discharge) has a significant influence on the thermal behaviors of LIBs. It can accelerate the warming up, result in earlier thermal runaway, and reduce the heat released. In addition, overcharge will make LIBs more unstable and easier to attain the thermal runaway.",
        "keywords": [
            "Lithium-ion battery",
            "Thermal runaway",
            "Discharging",
            "Overcharge",
            "Calorimeter"
        ],
        "authors": [
            {
                "name": "Dongxu\u00a0Ouyang",
                "org": "State Key Laboratory of Fire Science,University of Science and Technology of China,Hefei,China"
            },
            {
                "name": "Yaping\u00a0He",
                "org": "School of Engineering,University of Western Sydney,Sydney,Australia"
            },
            {
                "name": "Mingyi\u00a0Chen",
                "org": "School of Environment and Safety Engineering,University of Jiangsu,Zhenjiang,China"
            },
            {
                "name": "Jiahao\u00a0Liu",
                "org": "School of Marine Science and Engineering,University of Shanghai Maritime,Shanghai,China"
            },
            {
                "name": "Jian\u00a0Wang",
                "org": "State Key Laboratory of Fire Science,University of Science and Technology of China,Hefei,China"
            }
        ],
        "venue": "Journal of Thermal Analysis and Calorimetry",
        "year": 2018
    },
    "SLeOxA6g": {
        "id": "SLeOxA6g",
        "title": "Early smoke detection in video using swaying and diffusion feature",
        "abstract": "A method of early smoke detection in video using swaying and diffusion feature is presented in this paper. Firstly, in view of early smoke's swaying feature, choquet fuzzy integral was adopted to extract dynamic regions from video frames, and then, a swaying identification algorithm based on centroid calculation was used to distinguish candidate smoke region from other dynamic regions. Secondly, smoke diffusion makes different textures between the bottom region and the top region of smoke. This unique feature was used to differentiate smoke from other candidate smoke regions by Gray Level Co-occurrence Matrix. Experiments show that the proposed method is effective, robust, and has a performance of earlier smoke alarm. The processing rate of the smoke detection method achieves 25 frames per second with an image size of 320 \u00d7 240 pixels.",
        "keywords": [
            "bottom region",
            "dynamic region",
            "smoke diffusion",
            "earlier smoke alarm",
            "early smoke detection",
            "diffusion feature",
            "smoke detection method",
            "early smoke",
            "candidate smoke region",
            "proposed method"
        ],
        "authors": [
            {
                "name": "Shidong Wang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, PR China and Information Network Center, Anhui University of Architecture, Hefei, PR China"
            },
            {
                "name": "Yaping He",
                "org": "School of Computing Engineering and Mathematics, University of Western Sydney, Australia"
            },
            {
                "name": "Ju Jia Zou",
                "org": "School of Computing Engineering and Mathematics, University of Western Sydney, Australia"
            },
            {
                "name": "Dechuang Zhou",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, PR China"
            },
            {
                "name": "Jian Wang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, PR China"
            }
        ],
        "venue": "Journal of Intelligent and Fuzzy Systems",
        "year": 2014
    },
    "eKFnLF1y": {
        "id": "eKFnLF1y",
        "title": "Combustion of laminar non-premixed acetylene jet at two different altitudes",
        "abstract": "In this article, the influence of pressure variation due to altitude change on flames is studied. A series of largely buoyancy-driven acetylene jet fire experiments was conducted at two places in China, namely Lhasa and Hefei, with altitudes of 3658m and 50m, respectively. A range of parameters, including flame height, flame and plume centerline temperatures, transmittance through smoke, and irradiance were measured and compared. The flame height at low altitude is higher than that at high altitude. The centerline temperatures of the flame and plume regions exhibit opposite variations with pressure. The soot mass concentration resolved by transmittance measurement follows a weaker power-law dependence on pressure under substandard atmospheric pressure than under pressure greater than standard atmospheric pressure. The radiation heat flux produced from flames of the same burning rate displays a positive proportionality to pressure. \u00a9 2012 Copyright Taylor and Francis Group, LLC.",
        "keywords": [
            "burning rate",
            "diffusion jet",
            "emissivity",
            "flame height",
            "radiation",
            "temperature",
            "high altitude",
            "atmospheric pressure",
            "power law",
            "heat flux"
        ],
        "authors": [
            {
                "name": "Manjiang Yang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Yaping He",
                "org": "University of Western Sydney(University of Western Sydney),,Australia"
            },
            {
                "name": "Haihang Li",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Xiaocui Zhang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Zhenhua Li",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "Combustion Science and Technology",
        "year": 2012
    },
    "xgsj7UJv": {
        "id": "xgsj7UJv",
        "title": "Experimental study of large-scale fire behavior under low pressure at high altitude",
        "abstract": "To investigate the fire behavior under low pressure, four configurations of cardboard box fires were comparatively tested in a sea-level city, Hefei, and a high-altitude city, Lhasa. During each test, mass burning rate, total heat release rate, multipoint flame temperature, and radiative heat flux were measured. From the experimental data, some specific fire behavior was observed that (1) the mass burning rate divided by fire base dimension can be correlated against the production of pressure-squared times length-cubed (P2L3) to the power of 0.31, (2) the heat of combustion is lower in Lhasa probably due to the incomplete solid pyrolysis limited by oxygen, (3) the dimensionless plume temperature is correlated against the dimensionless flame height with a pressure term to the power of -2.0, and (4) the relative flame temperature estimated from the radiative heat flux indicated that the overall flame temperature is higher in Lhasa. \u00a9 The Author(s) 2013.",
        "keywords": [
            "fire behavior",
            "high altitude",
            "large-scale fire",
            "low pressure",
            "tibet plateau",
            "ergonomics",
            "human factors",
            "injury prevention",
            "occupational safety",
            "suicide prevention"
        ],
        "authors": [
            {
                "name": "Wei Yao",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Xiaokang Hu",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jianzhong Rong",
                "org": "Sichuan Fire Research Institute of Ministry of Public Security(Sichuan Fire Research Institute of Ministry of Pubic Security,Sichuan Fire Research Institute of Ministry of Public Security,Sichuan fire research institute of Ministry of Public Security),Chengdu,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Hui Zhang",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            }
        ],
        "venue": "Journal of Fire Sciences",
        "year": 2013
    },
    "x9c0reV9": {
        "id": "x9c0reV9",
        "title": "Selection of computational domain in numerical simulation of building fires",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jian wang",
                "org": ""
            },
            {
                "name": "zhenkum wu",
                "org": ""
            },
            {
                "name": "x xiao",
                "org": ""
            },
            {
                "name": "yaping he",
                "org": ""
            }
        ],
        "venue": "Fire Safety Science",
        "year": 2015
    },
    "1KykDs81": {
        "id": "1KykDs81",
        "title": "Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice.",
        "abstract": "",
        "keywords": [
            "cancer",
            "cell death",
            "apoptosis",
            "transforming growth factor beta",
            "cell growth",
            "micrornas",
            "cr",
            "immunology",
            "differentiation"
        ],
        "authors": [
            {
                "name": "jian wang",
                "org": ""
            },
            {
                "name": "yao song",
                "org": ""
            },
            {
                "name": "yan zhang",
                "org": ""
            },
            {
                "name": "h xiao",
                "org": ""
            },
            {
                "name": "qiang sun",
                "org": ""
            },
            {
                "name": "ning hou",
                "org": ""
            },
            {
                "name": "shuilong guo",
                "org": ""
            },
            {
                "name": "youliang wang",
                "org": ""
            },
            {
                "name": "kaiji fan",
                "org": ""
            },
            {
                "name": "dawei zhan",
                "org": ""
            },
            {
                "name": "lagabaiyila zha",
                "org": ""
            },
            {
                "name": "yang cao",
                "org": ""
            },
            {
                "name": "zhenhua li",
                "org": ""
            },
            {
                "name": "xuan cheng",
                "org": ""
            },
            {
                "name": "xiao yang",
                "org": ""
            }
        ],
        "venue": "Cell Research",
        "year": 2012
    },
    "MeDtI1YL": {
        "id": "MeDtI1YL",
        "title": "Fire flame detection based on GICA and target tracking",
        "abstract": "To improve the video fire detection rate, a robust fire detection algorithm based on the color, motion and pattern characteristics of fire targets was proposed, which proved a satisfactory fire detection rate for different fire scenes. In this fire detection algorithm: (a) a rule-based generic color model was developed based on analysis on a large quantity of flame pixels; (b) from the traditional GICA (Geometrical Independent Component Analysis) model, a Cumulative Geometrical Independent Component Analysis (C-GICA) model was developed for motion detection without static background and (c) a BP neural network fire recognition model based on multi-features of the fire pattern was developed. Fire detection tests on benchmark fire video clips of different scenes have shown the robustness, accuracy and fast-response of the algorithm. \u00a9 2012 Elsevier Ltd.",
        "keywords": [
            "cumulative geometrical independent component analysis",
            "generic color model",
            "video fire detection"
        ],
        "authors": [
            {
                "name": "Jianzhong Rong",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Dechuang Zhou",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Wei Yao",
                "org": "Tsinghua University(Tsinghua University,Tsinghua Univ,Tsinghua Univ.),Beijing,China"
            },
            {
                "name": "Wei Gao",
                "org": "University of Tokyo(University of Tokyo),Tokyo,Japan"
            },
            {
                "name": "Juan Chen",
                "org": "Zhejiang Institute of Safety Science and Technology(Zhejiang Academy of Safety Science and Technology,Zhejiang Institute of Safety Science and Technology),Hangzhou,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "Optics and Laser Technology",
        "year": 2013
    },
    "x9DMWXf6": {
        "id": "x9DMWXf6",
        "title": "Multi-feature fusion based fast video flame detection",
        "abstract": "A video flame detection method based on the multi-feature fusion is presented in this paper. The temporal and spatial characteristics of flames, such as ordinary flame movement and color clues, a flame flickering detection algorithm is incorporated into the scheme to detect fires in color video sequences. An improved Gaussian mixture model method is firstly adopted to extract moving foreground objects from the still background of detection scenes; secondly, detected moving objects are then categorized into candidate and non-candidate flame regions by using a flame color filtering algorithm; finally, a flame flicker identification algorithm based on statistical frequency counting is used to distinguish true flames from fire-like objects in video images. Testing results show that the proposed algorithms are effective, robust and efficient. The processing rate of the flame detection method can achieve 24 fps with image size of 320 \u00d7 240 pixels on a PC with an AMD 2.04 GHz processor.",
        "keywords": [
            "gaussian mixture model",
            "flickering analysis",
            "color mapping",
            "motion detection"
        ],
        "authors": [
            {
                "name": "Juan Chen",
                "org": "Zhejiang Key Laboratory of Safety Engineering and Technology Research, Zhejiang Institute of Safety Science and Technology, Hangzhou 310012, PR China"
            },
            {
                "name": "Yaping He",
                "org": "School of Engineering, University of Western Sydney, Australia"
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "Building and Environment",
        "year": 2010
    },
    "psdSwmYf": {
        "id": "psdSwmYf",
        "title": "Smoke venting and fire safety in an industrial warehouse",
        "abstract": "The intention of this paper is to demonstrate the feasibility of a performance-based solution for providing adequate life safety levels for the occupants of an industrial warehouse. Focus was given to the evaluation of the performance of a smoke venting system and the exit distribution in an industrial warehouse. Quantitative analyses of the available safe egress time and the required safe egress time were carried out using both a simple calculation and a computer modelling technique. The study included a sensitivity analysis to investigate multiple fire scenarios involving variations in design fires, ventilation conditions and number of exits. Computer simulations of fire growth and smoke spread in a large warehouse with a proportionally large ridge vent revealed somewhat interesting smoke movement patterns. The procedure for determining tenability in a well-ventilated high ceiling space is discussed. The result of the study demonstrated the acceptability of the alternative design solution against the established criterion. The limitations of the modelling technique and future research topics are also discussed.",
        "keywords": [
            "assessment",
            "tenability",
            "performance",
            "chimney effect",
            "sensitivity analysis",
            "injury prevention",
            "human factors",
            "computer simulation",
            "suicide prevention",
            "occupational safety",
            "ergonomics"
        ],
        "authors": [
            {
                "name": "Yaping He",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, People's Republic of China"
            },
            {
                "name": "Zhenkum Wu",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, People's Republic of China"
            },
            {
                "name": "Lu Hu",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, People's Republic of China"
            },
            {
                "name": "Yi Xiong",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, People's Republic of China"
            },
            {
                "name": "Weicheng Fan",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei 230026, People's Republic of China"
            }
        ],
        "venue": "Fire Safety Journal",
        "year": 2002
    },
    "As4xPZfb": {
        "id": "As4xPZfb",
        "title": "Temporal scaling behavior of human-caused fires and their connection to relative humidity of the atmosphere",
        "abstract": "It has been found that many natural systems are characterized by scaling behavior. In such systems natural factors dominate the event dynamics. But in countries with high population density such as China and Japan, more than 95% of the forest fire disasters are caused by human activities. Furthermore, with the development of society, the wildland\u2013urban interface (WUI) area is becoming more and more populated, and the forest fire is much connected with urban fire. Therefore exploring the scaling behavior of fires dominated by human-related factors is very challenging. The present paper explores the temporal scaling behavior of forest fires and urban fires in Japan. Our findings point out that although the human factors are the main cause, both the forest fires and urban fires exhibit time-scaling behavior. Similar distribution law characterizes the relative humidity.",
        "keywords": [
            "fano factor",
            "allan factor",
            "scaling behavior",
            "fire pattern",
            "weather parameter",
            "distributive law",
            "population density",
            "human factors",
            "relative humidity"
        ],
        "authors": [
            {
                "name": "Jian Wang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, 230026, PR China"
            },
            {
                "name": "Weiguo Song",
                "org": ""
            },
            {
                "name": "Hongyang Zheng",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, 230026, PR China"
            },
            {
                "name": "Luciano Telesca",
                "org": "Institute of Methodologies for Environmental Analysis, National Research Council, Tito (PZ), Italy"
            }
        ],
        "venue": "Ecological Modelling",
        "year": 2010
    },
    "NbvHOWOd": {
        "id": "NbvHOWOd",
        "title": "GP1-2: Autocrine human growth hormone suppression of E-CADHERIN via p44/42 MAPK promotes epithelial-tomesenchymal transition (EMT) of colorectal carcinoma cells",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "peter e lobie",
                "org": ""
            },
            {
                "name": "tao zhu",
                "org": ""
            },
            {
                "name": "y chen",
                "org": ""
            },
            {
                "name": "vijay pandey",
                "org": ""
            },
            {
                "name": "zhenkum wu",
                "org": ""
            },
            {
                "name": "jian wang",
                "org": ""
            }
        ],
        "venue": "Growth Hormone & Igf Research",
        "year": 2014
    },
    "W18IKYfO": {
        "id": "W18IKYfO",
        "title": "Combustion characteristics of n-heptane and wood crib fires at different altitudes",
        "abstract": "This paper contains descriptions of a preliminary experimental investigation of the fire combustion characteristics at different altitudes. Fire experiments were conducted in two laboratories located at different altitudes. Two n -heptane tanks and two wood cribs were used in the fire experiments conducted in two combustion chambers of the same size. Several parameters, including flame temperature, thermal radiation flux and fuel mass loss, were measured. Significant differences in the combustion characteristics at two difference latitudes were revealed. The experimental data show that for the same burning surface area, the burning rate, radiation heat flux and flame temperature at the high altitude was lower than those at the low altitude. For the same burning rate, the measured radiation heat flux at high altitude was lower than that at low altitude, though the average flame temperature was higher.",
        "keywords": [
            "emissivity",
            "burning rate",
            "temperature",
            "radiation heat flux",
            "heat flux",
            "high altitude",
            "surface area",
            "thermal radiation"
        ],
        "authors": [
            {
                "name": "Zhen-hua Li",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, 96 JingZai Road, Hefei, Anhui 230026, PR China"
            },
            {
                "name": "Yaping He",
                "org": "School of Engineering, University of Western Sydney, Australia"
            },
            {
                "name": "Hui Zhang",
                "org": "Department of Engineering Physics, Tsinghua University, Beijing 100084, PR China"
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "Proceedings of the Combustion Institute",
        "year": 2009
    },
    "62oLU2Cj": {
        "id": "62oLU2Cj",
        "title": "Combustion and smoke characteristics of circle-pan fire under low pressure and low oxygen concentration",
        "abstract": "To study and compare the combustion and smoke characteristics at different altitudes, a set of n-heptane pool fire experiments were conducted in Lhasa and Hefei. The combustion and smoke parameters, such as fuel mass loss, flame temperature, irradiance, transmittance through smoke, flame height and smoke concentration, were measured. The experimental results show that, with the increase of altitude, burning rate per unit area, average flame axis temperature, radiation heat flux, smoke emissivity, carbon monoxide and carbon dioxide concentrations decrease.",
        "keywords": [
            "Combustion characteristic",
            "Radiation heat flux",
            "Smoke characteristic",
            "Smoke concentration",
            "Temperature"
        ],
        "authors": [
            {
                "name": "Xiaokang Hu",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Yaping He",
                "org": "University of Western Sydney(University of Western Sydney),,Australia"
            },
            {
                "name": "Zhenhua Li",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Juan Chen",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            }
        ],
        "venue": "Ranshao Kexue Yu Jishu/Journal of Combustion Science and Technology",
        "year": 2011
    },
    "Qm2AbdD5": {
        "id": "Qm2AbdD5",
        "title": "An Improved and Practical Synthesis of Tranexamic Acid",
        "abstract": "Tranexamic acid 1, a synthetic antifibrinolytic drug with the treatment being considered highly cost-effective in many countries, has been included in the WHO list of essential medicines. In this paper, we designed the synthesis of 1 via a novel seven-step route from the readily available starting material dimethyl terephthalate, performing with 99.6% purity in 59.2% overall yield. During the process, we successfully developed a direct and efficient method for the preparation of key intermediate methyl 4-(acetamidomethyl)benzoate by one-pot hydrogenation and acylation in acetic anhydride using Ni/Al2O3 as a catalyst. More importantly, it should be a straightforward and practical way to circumvent the usage of toxic reagents (CrO3, Cl2), solvent (CCl4), and expensive catalyst (PtO2), etc., that plagued the previous methodologies.",
        "keywords": [],
        "authors": [
            {
                "name": "yuanyuan xie",
                "org": ""
            },
            {
                "name": "yanna guo",
                "org": ""
            },
            {
                "name": "liuhong dong",
                "org": ""
            },
            {
                "name": "jian wang",
                "org": ""
            },
            {
                "name": "li fang",
                "org": ""
            },
            {
                "name": "zhenhua li",
                "org": ""
            }
        ],
        "venue": "Organic Process Research & Development",
        "year": 2015
    },
    "qMCRfDIl": {
        "id": "qMCRfDIl",
        "title": "Combustion characteristics of n-heptane at high altitudes",
        "abstract": "Presented in this paper is part of an experimental series conducted at different altitudes to investigate the influence of ambient pressure on buoyancy driven diffusion combustion of a liquid fuel. A set of n -heptane pool fire experiments were conducted at two geographic locations on the Tibetan plateau with altitudes greater than 3600 m. In addition to the measurements of fuel mass loss, flame temperature and irradiance, transmittance through smoke and flame height were also measured. The experimental results confirm the findings of previous studies at relatively lower altitudes and show that the burning rate per unit area, radiation heat flux and average flame axis temperature decrease when the altitude is increased. Direct evidence was also obtained to show that the radial average extinction coefficient at a given height above the fuel surface is inversely proportional to the altitude. A preliminary discussion is made on the mechanism of pressure influence on buoyancy driven fire behavior.",
        "keywords": [
            "extinction coefficient",
            "burning rate",
            "temperature",
            "radiant heat flux",
            "buoyancy",
            "heat flux",
            "high altitude"
        ],
        "authors": [
            {
                "name": "Xiaokang Hu",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, Anhui 230026, PR China"
            },
            {
                "name": "Yaping He",
                "org": "School of Engineering, University of Western Sydney, Locked Bag 1797, Penrith South DC, NSW 1797, Australia"
            },
            {
                "name": "Zhenhua Li",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, Anhui 230026, PR China"
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "Proceedings of the Combustion Institute",
        "year": 2011
    },
    "a5wZyF2M": {
        "id": "a5wZyF2M",
        "title": "Downregulation of SPARC expression inhibits the invasion of human trophoblast cells in vitro.",
        "abstract": "Successful pregnancy depends on the precise regulation of extravilloustrophoblast (EVT) invasion into the uterine decidua. SPARC (secreted protein acidic and rich in cysteine) is a matricellular glycoprotein that plays critical roles in the pathologies associated with obesity and diabetes, as well as tumorigenesis. The objective of this study was to investigate the role of SPARC in the process of trophoblast invasion which shares many similarities with tumor cell invasion. By Western blot, higher expression of SPARC was observed in mouse brain, ovary and uterus compared to other mouse tissues. Immunohistochemistry analysis revealed a spatio-temporal expression of SPARC in mouse uterus in the periimplantation period. At the implantation site of d8 pregnancy, SPARC mainly accumulated in the secondary decidua zone (SDZ), trophoblast cells and blastocyst. The expression of SPARC was also detected in human placental villi and trophoblast cell lines. In a Matrigel invasion assay, we found SPARC-specific RNA interference significantly reduced the invasion of human extravilloustrophoblast HTR8/SVneo cells. Microarray analysis revealed that SPARC depletion upregulated the expression of interleukin 11 (IL11), KISS1, insulin-like growth factor binding protein 4 (IGFBP4), collagen type I alpha 1 (COLIA1), matrix metallopeptidase 9 (MMP9), and downregulated the expression of the alpha polypeptide of chorionic gonadotropin (CGA), MMP1, gap junction protein alpha 1 (GJA1), et al. The gene array result was further validated by qRT-PCR and Western blot. The present data indicate that SPARC may play an important role in the regulation of normal placentation by promoting the invasion of trophoblast cells into the uterine decidua.",
        "keywords": [
            "gene expression",
            "gene expression profiling",
            "cell line",
            "up regulation",
            "immunohistochemistry",
            "microarrays",
            "medicine",
            "engineering",
            "chemistry",
            "biology",
            "rna interference",
            "protein structure",
            "down regulation",
            "physics"
        ],
        "authors": [
            {
                "name": "Yahong Jiang",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            },
            {
                "name": "Yan Zhu",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            },
            {
                "name": "Yan Shi",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            },
            {
                "name": "Yaping He",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            },
            {
                "name": "Zhichao Kuang",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            },
            {
                "name": "Zhaogui Sun",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            },
            {
                "name": "Jian Wang",
                "org": "Shanghai Institute of Planned Parenthood Research(Shanghai Institute of Planned Parenthood Research,Shanghai Inst. Planned Parenthood R.),Shanghai,China"
            }
        ],
        "venue": "PloS one",
        "year": 2013
    },
    "Onmr2HL0": {
        "id": "Onmr2HL0",
        "title": "Detrended fluctuation analysis of forest fires and related weather parameters",
        "abstract": "Power-law scaling behaviors of the real forest fires and weather parameters are analyzed by means of the detrended fluctuation analysis (DFA) method. It is found that the fire area series behave persistent long-range power-law correlations, with the scaling exponent 0.67, in the timescale larger than 3.9 days. In the smaller timescale it has similar characteristics like that of the white noise. The weather parameters are investigated then to reveal their connection to the forest fire. It is found that the temperature, relative humidity and rainfall records all exhibit long-range power-law correlations in large timescales. The scaling exponents are 0.89, 0.72, and 0.69, corresponding to timescales larger than 5.2 days, 4.67 days and 5.2 days respectively. The results imply that the scaling behaviors, such as the power law and the crossover, of the forest fire and the weather parameters have similar characteristics. The results seem to be helpful to quantify the underlying dynamics of the forest fire and the weather parameters, and to understand the underlying relationship between them.",
        "keywords": [
            "detrended fluctuation analysis",
            "weather",
            "power law",
            "forest fire",
            "relative humidity",
            "white noise"
        ],
        "authors": [
            {
                "name": "Hongyang Zheng",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, 230026, PR China"
            },
            {
                "name": "Weiguo Song",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": "State Key Laboratory of Fire Science, University of Science and Technology of China, Hefei, 230026, PR China"
            }
        ],
        "venue": "Physica A: Statistical Mechanics and its Applications",
        "year": 2008
    },
    "yWCaXS1J": {
        "id": "yWCaXS1J",
        "title": "Weather-driven model indicative of spatiotemporal power laws.",
        "abstract": "In the traditional Drossel-Schwabl forest fire model (DS model), the frequency distributions of fire size and fire interval follow a power law and an exponential law, respectively. However, it is found that the frequency-interval distribution of actual forest fires is not exponential, but a power law with periodical fluctuations which may be caused by the daily cycle of weather parameters. Therefore, a weather driven forest fire model (WD model) is built considering actual hourly weather records, with which the fire igniting probability is calculated. The simulation results indicate that the frequency-interval distribution of the WD model agrees with that of actual forest fire data and, at the same time, the frequency-size distributions of the WD and the DS models are in accordance with each other. In the further analysis of the temporal property of weather data, it is found that the change of weather data also exhibits a power-law relation with periodic fluctuations, implying that the external driving from weather parameters is the essential reason for the power-law distribution of fire intervals. The results suggest that natural systems may be coupled with each other and that the decoupling of systems is important to identifying system characteristics.",
        "keywords": [],
        "authors": [
            {
                "name": "Weiguo Song",
                "org": ""
            },
            {
                "name": "Hongyang Zheng",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Jian Ma",
                "org": ""
            },
            {
                "name": "Kohyu Satoh",
                "org": ""
            }
        ],
        "venue": "Physical review. E, Statistical, nonlinear, and soft matter physics",
        "year": 2007
    },
    "BwEHiVti": {
        "id": "BwEHiVti",
        "title": "A Flame Detection Synthesis Algorithm",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jian wang",
                "org": "anhui university"
            },
            {
                "name": "shidong wang",
                "org": "university of western sydney"
            },
            {
                "name": "yaping he",
                "org": "university of western sydney"
            },
            {
                "name": "ju jia zou",
                "org": "hefei university"
            },
            {
                "name": "baobin duan",
                "org": "university of science and technology of china"
            }
        ],
        "venue": "Fire Technology",
        "year": 2015
    },
    "rebHB6bp": {
        "authors": [
            {
                "name": "Zhongmin Qiu",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Weili Wei",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Li Yu",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Yu Wang",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Xin Li",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Zhihong Qiu",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Lan Wang",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Bo Liu",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Siwei Liang",
                "org": "Department of Respiratory Medicine"
            },
            {
                "name": "Hanjing L\u00fc",
                "org": "Department of Respiratory Medicine"
            }
        ],
        "title": "Efficacy and safety of modified sequential three-step empirical therapy for chronic cough",
        "abstract": "Background and objective: Sequential three-step empirical therapy is useful for the management of chronic cough. The purpose of this study was to evaluate the efficacy and safety of modified sequential three-step empirical therapy. Methods: Consecutive patients (n = 240) with chronic cough were recruited and randomly assigned to receive modified (modified group) or primary (primary group) sequential three-step empirical therapy. The primary end-point was the overall rate of control of chronic cough. Secondary end-points were the rate of control of chronic cough at each step of therapy, the duration of treatment required, changes in cough symptom score, health-related quality of life and possible adverse effects. Results: The study was completed by 106 patients in the modified group and 108 patients in the primary group. The overall rate of control of chronic cough was 88.7% in the modified group and 91.7% in the primary group ( ",
        "keywords": [
            "antihistamine",
            "bronchodilator",
            "chronic cough",
            "corticosteroid",
            "empirical therapy"
        ],
        "venue": "Respirology",
        "year": 2010,
        "id": "rebHB6bp"
    },
    "CzZ8zver": {
        "authors": [
            {
                "name": "Lele Kang",
                "org": "School of Information Management, Nanjing University"
            },
            {
                "name": "Xiang Wang",
                "org": "Department of Marketing and E-Business, Nanjing University"
            },
            {
                "name": "Chuan-Hoo Tan",
                "org": "Department of Information Systems, City University of Hong Kong"
            },
            {
                "name": "J. Leon Zhao",
                "org": "Department of Information Systems, City University of Hong Kong"
            }
        ],
        "title": "Understanding the Antecedents and Consequences of Live Chat Use in Electronic Markets",
        "abstract": "Online shopping has progressed from having consumers passively browse through the webpages of online stores to having them proactively engage in communication dialogues with the sellers themselves via live chat. Modern-day consumers can now directly contact online sellers and inquire about the products they intend to purchase through the live chat medium available in the webpages of online stores, such as Taobao.com. In this study, the conceptual framework of motivation, opportunity, and ability was extended to understand the antecedents of using live chat and to lengthen such an understanding on one\u2019s eventual intention to transact on the website from the trust-oriented perspective. A total of 222 online consumers of Taobao.com were surveyed, and their responses validated the proposed conceptual model and confirmed the research hypotheses. Results of the investigation indicated that perceived information asymmetry and fears of seller opportunism, encapsulated under motivation dimension, and perceived personal expertise, which manifests ability dimension, significantly influence the use of live chat by consumers. The results further demonstrated that live chat use positively affects the perceived interactivity of consumers, thereby increasing their intention to transact. The influence of live chat use on the perceived interactivity of consumers and its effect on one\u2019s intention to transact online are negatively moderated by the trust of consumers in a seller. The findings contribute to our understanding communication services for e-commerce in general and to the realization of real-time communication technology in particular.",
        "keywords": [
            "e-commerce",
            "intention to transact",
            "live chat",
            "MOA framework",
            "trust"
        ],
        "venue": "Journal of Organizational Computing and Electronic Commerce",
        "year": 2015,
        "id": "CzZ8zver"
    },
    "zpyPbao1": {
        "authors": [
            {
                "name": "Lele Kang",
                "org": "Department of Information Systems, City University of Hong Kong"
            },
            {
                "name": "Xiang Wang",
                "org": "Department of Electronic Business, Nanjing University"
            },
            {
                "name": "Chuan-Hoo Tan",
                "org": "Department of Information Systems, City University of Hong Kong"
            },
            {
                "name": "J. Leon Zhao",
                "org": "Department of Information Systems, City University of Hong Kong"
            }
        ],
        "title": "Understanding the antecedents and consequences of live-chat use in e-commerce context",
        "abstract": "Online shopping has progressed from having consumers passively browse through web pages of products to having them proactively engage in communication dialogs with product sellers via Live-Chat. Through Live-Chat, consumers can directly contact the sellers and inquire about their products of interest. This study extends the conceptual framework of motivation, opportunity, and ability (MOA) to understand the antecedents and consequences of Live-Chat usage in consumers' online shopping process. Our survey involving 222 online consumers validated the proposed conceptual model and confirmed most of our assumptions. For antecedents, we found that MOA factors generally influence the Live-Chat usage of consumers in their shopping process. Specifically, perceived information asymmetry, fears of seller opportunism and perceived personal expertise have strong positive effects on Live-Chat usage. For consequences, Live-Chat usage positively affects consumers' perceived interactivity, thereby reducing their uncertainty in transaction. Our findings contribute to the understanding of real-time communication technology in specific and digital service for e-commerce in general. \u00a9 2014 Springer International Publishing.",
        "keywords": [
            "E-Commerce",
            "Live-Chat",
            "Motivation-Opportunity-Ability Framework"
        ],
        "venue": "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
        "year": 2014,
        "id": "zpyPbao1"
    },
    "T5pz4Ezo": {
        "authors": [
            {
                "name": "Xiang Wang",
                "org": "School of Business, Nanjing University"
            },
            {
                "name": "Shuyan Ding",
                "org": "School of Business, Nanjing University"
            }
        ],
        "title": "Constructing autonomy oriented network learning mechanism of generation y",
        "abstract": "Autonomy Oriented Education (AOE) is a common focus of academia and business community. In this paper, based on the successful experience in the promotion of Autonomy Oriented Education, we present the background, concept, empowerment mechanisms, psychological support, as well as practical applications of AOE in Europe, and conclude relevant recommendations of constructing autonomy oriented network learning mechanism of domestic Generation Y.",
        "keywords": [
            "Autonomous learning",
            "Autonomy oriented education",
            "Generation Y"
        ],
        "venue": "Proceedings - Pacific Asia Conference on Information Systems, PACIS 2013",
        "year": 2013,
        "id": "T5pz4Ezo"
    },
    "dqMdfCFs": {
        "authors": [
            {
                "name": "Zhi-Gang Chen",
                "org": ""
            },
            {
                "name": "Xiao-Li Tang",
                "org": ""
            },
            {
                "name": "Jing Su",
                "org": ""
            },
            {
                "name": "Xi Liu",
                "org": ""
            }
        ],
        "title": "Influences of volume content of WC on wear resistance of sprayed coating",
        "abstract": "Flame spray was carried out by mixing different content of WC into self-fusing F102 metal powders. The influences of WC content upon wear resistance of sprayed coating were studied through testing of macroscopic hardness, low-stress abrasive particle wear resistance and analyse of microstracture of sprayed coating. The results show that when the volume content of WC is 1%, the quality of the coating is the best. With the volume content of WC increasing, the wear resistance and hardness decrease.",
        "keywords": [
            "Abrasive particle wear",
            "Flame spray",
            "Superfine WC",
            "Volume content",
            "Wear resistance"
        ],
        "venue": "Jiangsu Daxue Xuebao (Ziran Kexue Ban) / Journal of Jiangsu University (Natural Science Edition)",
        "year": 2006,
        "id": "dqMdfCFs"
    },
    "EcDy9LFz": {
        "authors": [
            {
                "name": "Hong-Yu Wang",
                "org": "Institute of Advanced Forming Technology"
            },
            {
                "name": "Xue-Feng Zhang",
                "org": "Institute of Advanced Forming Technology"
            },
            {
                "name": "Xiao-Jing Xu",
                "org": "Institute of Advanced Forming Technology"
            },
            {
                "name": "Xi Liu",
                "org": "Institute of Advanced Forming Technology"
            },
            {
                "name": "Kang-Min Chen",
                "org": "Institute of Advanced Forming Technology"
            },
            {
                "name": "Li Pan",
                "org": "Institute of Advanced Forming Technology"
            }
        ],
        "title": "Influence of spray-welding technology on microstructures and properties of Ni-based coating on titanium substrate",
        "abstract": "The Ni based wear resistance coatings on the Ti-6Al-4V alloy substrate by common flames spray-welding technique and flames spray-welding improved technique were prepared. The microstructures and the elements distributions of coating were analyzed, and the microhardness and adhesion properties were studied. The results show that the microstructures and properties of coating prepared by the improved technique have been improved obviously, the uniformity of coating microstructure is improved and its grains become smaller, the adhesion of the substrate and the coating is metallurgical bonding. The change of microhardness for coating are continuous and gradual along depth direction, and the microhardness of spray-welding surface is HV933.2. It indicates that adopting improved spray-welding technique is able to prepare excellent wear resistance coating on the titanium alloys substrate.",
        "keywords": [
            "Flames spray-welding",
            "Microstructure",
            "Ni-based coating",
            "Property",
            "Titanium alloy"
        ],
        "venue": "Zhongguo Youse Jinshu Xuebao/Chinese Journal of Nonferrous Metals",
        "year": 2005,
        "id": "EcDy9LFz"
    },
    "x25ZiSuk": {
        "authors": [
            {
                "name": "Xiaojing Xu",
                "org": "Jiangsu University"
            },
            {
                "name": "Hongyu Wang",
                "org": "Jiangsu University"
            },
            {
                "name": "Kangmin Chen",
                "org": "Jiangsu University"
            },
            {
                "name": "Xi Liu",
                "org": "Jiangsu University"
            },
            {
                "name": "Wenwei Xu",
                "org": "Jiangsu University"
            }
        ],
        "title": "Microstructure and properties of flames spray-welding Ni-based wear resistance coating on titanium alloys substrate",
        "abstract": "The Ni-based wear resistance coating on titanium alloys substrate made by flames spray-welding technique has been prepared, and the microstructure, the element distribution and the microhardness of the coating and its tribological properties under dry sliding against steel were determined. The results show that the microstructure of spray-welding layer is characterized by a wear resistant microstructure composed by tough substrate and hard particles, the microstructure, the microhardness and the element distribution in the cross section change continuously and gradually along the depth direction, and a metallurgical bonding has been formed between coating and substrate, the microhardness of its surface is 933. 2 HV, which is 3 times higher than that of titanium alloy substrate, the wear loss of the coating is little in all experimental conditions, so the wear resistance has been improved considerably, moreover, it is found that speed and temperature have obvious influence to its wear resistance.",
        "keywords": [
            "Flames spray-welding",
            "Microstructure",
            "Ni-based coating",
            "Titanium alloys",
            "Tribological properties"
        ],
        "venue": "Nongye Jixie Xuebao/Transactions of the Chinese Society of Agricultural Machinery",
        "year": 2006,
        "id": "x25ZiSuk"
    },
    "3j03lUTR": {
        "id": "3j03lUTR",
        "title": "Analysis of Anomalous Characters of the Time-Latitude Residuals of Yunnan Observatory Before Major Earthquakes",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiaoming li",
                "org": ""
            },
            {
                "name": "jun tian",
                "org": ""
            },
            {
                "name": "hui hu",
                "org": ""
            },
            {
                "name": "rongu kan",
                "org": ""
            }
        ],
        "venue": "",
        "year": 1996
    },
    "dmN2b82V": {
        "id": "dmN2b82V",
        "title": "OBSERVATIONS OF RADIO STRAS FROM ASTROLABE OF YUNNAN OBSERVATORY",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hui hu",
                "org": ""
            },
            {
                "name": "dongming li",
                "org": ""
            },
            {
                "name": "xiaoming li",
                "org": ""
            },
            {
                "name": "rui wang",
                "org": ""
            }
        ],
        "venue": "Journal of the Korean Astronomical Society",
        "year": 1996
    },
    "W1sv5ioD": {
        "id": "W1sv5ioD",
        "title": "The photoelectric astrolabe catalogue of Yunnan Observatory (YPAC)",
        "abstract": "The positions of 53 FK5, 70 FK5 Extension and 486 GC stars are given for the equator and equinox J2000.0 and for the mean observation epoch of each star. They are determined with the photoelectric astrolabe of Yunnan Observatory. The internal mean errors in right ascension and declination are \ufffd\ufffd0\ufffd\ufffd.046 and \ufffd\ufffd0\ufffd\ufffd.059, respectively. The mean observation epoch is 1989.51.",
        "keywords": [
            "astrometry",
            "catalogue",
            "mean error"
        ],
        "authors": [
            {
                "name": "hui hu",
                "org": ""
            },
            {
                "name": "dongming li",
                "org": ""
            },
            {
                "name": "yongsheng li",
                "org": ""
            },
            {
                "name": "rui wang",
                "org": ""
            },
            {
                "name": "xiaoming li",
                "org": ""
            }
        ],
        "venue": "Astronomy and Astrophysics Supplement Series",
        "year": 1996
    },
    "asrIb6FZ": {
        "id": "asrIb6FZ",
        "title": "Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production.",
        "abstract": "Exposure to ionizing radiation (IR) induces various types of DNA damage, of which DNA double-strand breaks are the most severe, leading to genomic instability, tumorigenesis, and cell death. Hence, cells have developed DNA damage responses and repair mechanisms. IR also causes the accumulation of endogenous reactive oxidative species (ROS) in the irradiated cells. Upon exposure to low-dose irradiation, the IR-induced biological effects mediated by ROS were relatively more significant than those mediated by DNA damage. Accumulating evidence suggests that such increase in endogenous ROS is related with mitochondria change in irradiated cells. Thus, in this review we focused on the mechanism of mitochondrial ROS production and its relationship to the biological effects of IR. Exposure of mammalian cells to IR stimulates an increase in the production of endogenous ROS by mitochondria, which potentially leads to mitochondrial dysfunction. Since the remains of damaged mitochondria could generate or leak more ROS inside the cell, the damaged mitochondria are removed by mitophagy. The disruption of this pathway, involved in maintaining mitochondrial integrity, could lead to several disorders (such as neurodegeneration) and aging. Thus, further investigation needs to be performed in order to understand the relationship between the biological effects of low-dose IR and mitochondrial integrity.",
        "keywords": [
            "ROS",
            "low-dose irradiation",
            "mitochondria",
            "mitophagy",
            "oxidative damage"
        ],
        "authors": [
            {
                "name": "Kasumi Kawamura",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Fei Qi",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Junya Kobayashi",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            }
        ],
        "venue": "Journal of radiation research",
        "year": 2018
    },
    "ahqUsEDM": {
        "id": "ahqUsEDM",
        "title": "Regulation of replication stress-induced responses by nucleolin",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Kasumi Kawamura",
                "org": "Dept. of Interdisciplinary Environment"
            },
            {
                "name": "Hui Zhou",
                "org": ""
            },
            {
                "name": "Fei Qi",
                "org": "Dept. of Interdisciplinary Environment"
            },
            {
                "name": "Ikue Hayashi",
                "org": ""
            },
            {
                "name": "Junya Kobayashi",
                "org": "Dept. of Interdisciplinary Environment"
            }
        ],
        "venue": "The Molecular Biology Society of Japan",
        "year": 2016
    },
    "H6bSjQXV": {
        "id": "H6bSjQXV",
        "title": "Nucleolar protein nucleolin functions in replication stress-induced DNA damage responses.",
        "abstract": "The nucleolus contains multiple copies of ribosomal (r)DNA, which indicate sites of frequent replication stress and suggest the existence of a mechanism to prevent replication stress-related rDNA instability and the possibility that such a mechanism contributes to the whole genomic stability against replication stress. We have previously reported that nucleolin, a major nucleolar protein, is involved in ionizing radiation-induced DNA damage responses (DDRs) such as ataxia telangiectasia mutated (ATM)-dependent cell cycle checkpoints and homologous recombination (HR) repair. Here, we investigated the role of nucleolin in DDR due to replication stress. The results indicate that following replication stress, nucleolin interacted with the histone \u03b3H2AX, proliferating cell nuclear antigen (PCNA), and replication protein A (RPA)32, suggesting that it may be recruited to DNA damage sites on the replication fork. Furthermore, the knockdown of nucleolin by siRNA reduced the activation of ATM and RAD3-related (ATR) kinase and the formation of RAD51 and RPA32 foci after replication stress due to UV or camptothecin exposure, whereas nucleolin overexpression augmented ATR-dependent phosphorylation and RAD51 and RPA accumulation on chromatin. Moreover, these overexpressing cells seemed to increase repair activity and resistance to replication stress. Our results indicate that nucleolin plays an important role in replication stress-induced DDRs such as ATR activation and HR repair. Given that nucleolin overexpression is often observed in many types of cancer cells, our findings suggest that nucleolin is involved in the regulation of resistance to replication stress that may otherwise lead to tumorigenesis and it could be a possible target for chemotherapy and radiotherapy.",
        "keywords": [
            "ATR",
            "DNA damage",
            "nucleolin",
            "nucleolus",
            "replication stress"
        ],
        "authors": [
            {
                "name": "Kasumi Kawamura",
                "org": "Department of Interdisciplinary Environment, Graduate School of Human and Environmental Sciences, Kyoto University, Yoshidanihonmatsucho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Fei Qi",
                "org": "Department of Interdisciplinary Environment, Graduate School of Human and Environmental Sciences, Kyoto University, Yoshidanihonmatsucho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Qingmei Meng",
                "org": "Department of Interdisciplinary Environment, Graduate School of Human and Environmental Sciences, Kyoto University, Yoshidanihonmatsucho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Ikue Hayashi",
                "org": "Graduate School of Biomedical Sciences, Hiroshima University, Kasumi1-2-3, Minamiku, Hiroshima 734-8553, Japan."
            },
            {
                "name": "Junya Kobayashi",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Graduate School of Biostudies, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            }
        ],
        "venue": "Journal of radiation research",
        "year": 2019
    },
    "zrW4YQQZ": {
        "id": "zrW4YQQZ",
        "title": "Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production.",
        "abstract": "Exposure to ionizing radiation (IR) induces various types of DNA damage, of which DNA double-strand breaks are the most severe, leading to genomic instability, tumorigenesis, and cell death. Hence, cells have developed DNA damage responses and repair mechanisms. IR also causes the accumulation of endogenous reactive oxidative species (ROS) in the irradiated cells. Upon exposure to low-dose irradiation, the IR-induced biological effects mediated by ROS were relatively more significant than those mediated by DNA damage. Accumulating evidence suggests that such increase in endogenous ROS is related with mitochondria change in irradiated cells. Thus, in this review we focused on the mechanism of mitochondrial ROS production and its relationship to the biological effects of IR. Exposure of mammalian cells to IR stimulates an increase in the production of endogenous ROS by mitochondria, which potentially leads to mitochondrial dysfunction. Since the remains of damaged mitochondria could generate or leak more ROS inside the cell, the damaged mitochondria are removed by mitophagy. The disruption of this pathway, involved in maintaining mitochondrial integrity, could lead to several disorders (such as neurodegeneration) and aging. Thus, further investigation needs to be performed in order to understand the relationship between the biological effects of low-dose IR and mitochondrial integrity.",
        "keywords": [
            "ROS",
            "low-dose irradiation",
            "mitochondria",
            "mitophagy",
            "oxidative damage"
        ],
        "authors": [
            {
                "name": "Kasumi Kawamura",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Fei Qi",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            },
            {
                "name": "Junya Kobayashi",
                "org": "Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Yoshidakonoecho, Sakyo-ku, Kyoto 606-8501, Japan."
            }
        ],
        "venue": "Journal of radiation research",
        "year": 2018
    },
    "wwUePFEP": {
        "authors": [
            {
                "name": "Lan Luo",
                "org": "Institute for Mathematics and Information Sciences"
            },
            {
                "name": "Yong-Ye Zhao",
                "org": "School of Mathematics and Computional Science"
            },
            {
                "name": "Qing Yang",
                "org": "School of Mathematics and Computional Science"
            }
        ],
        "title": "Regularity criteria for the three-dimensional MHD equations",
        "abstract": "In this paper, we consider regularity criteria for solutions to the 3D MHD equations with incompressible conditions. By using some classical inequalities, we obtain the regularity of strong solutions to the three-dimensional MHD equations under certain sufficient conditions in terms of one component of the velocity field and the magnetic field respectively. \u00a9 2011 Institute of Applied Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "MHD equations",
            "regularity",
            "strong solution"
        ],
        "venue": "Acta Mathematicae Applicatae Sinica",
        "year": 2011,
        "id": "wwUePFEP"
    },
    "nBhRswVh": {
        "authors": [
            {
                "name": "Chen Fan",
                "org": ""
            },
            {
                "name": "Wei Xu",
                "org": ""
            },
            {
                "name": "Tao Zhang",
                "org": ""
            },
            {
                "name": "Leon Zhou",
                "org": ""
            },
            {
                "name": "Bo Jiang",
                "org": ""
            },
            {
                "name": "Wanmeng Mu",
                "org": ""
            }
        ],
        "title": "Engineering of Alicyclobacillus hesperidum l-Arabinose Isomerase for Improved Catalytic Activity and Reduced pH Optimum Using Random and Site-Directed Mutagenesis",
        "abstract": "A mutation, D478N, was obtained by an error-prone polymerase chain reaction using the l-arabinose isomerase (l-AI) gene from Alicyclobacillus hesperidum URH17-3-68 as the template. The mutated isomerase showed higher activity for d-galactose isomerization. The mutation site obtained from random mutagenesis was then introduced as a single-site mutation using site-directed mutagenesis. Single-site variants, D478N, D478Q, D478A, D478K, and D478R, were constructed. The optimum temperatures were all higher than 60\u00a0\u00b0C. D478A, D478N, and D478Q retained more than 80\u00a0% of the maximum relative activity of the wild-type l-AI at 75\u00a0\u00b0C. With the exception of the D478A variant, all variants showed decreased optimum pH values in the acidic range (6.0\u20136.5). All of the variant l-AIs could be significantly activated by the addition of Co",
        "keywords": [
            "d-tagatose",
            "Error-prone PCR",
            "l-Arabinose isomerase",
            "Random mutagenesis",
            "Site-directed mutagenesis"
        ],
        "venue": "Applied Biochemistry and Biotechnology",
        "year": 2015,
        "id": "nBhRswVh"
    },
    "VSEIC00X": {
        "authors": [
            {
                "name": "Ming Miao",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Yajun Ma",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Chao Huang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Bo Jiang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Steve W. Cui",
                "org": "Guelph Food Research Centre, Agriculture and Agri-Food Canada"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            }
        ],
        "title": "Physicochemical properties of a water soluble extracellular homopolysaccharide from Lactobacillus reuteri SK24.003",
        "abstract": "Abstract A water soluble exopolysaccharide was obtained from Lactobacillus reuteri SK24.003 and its rheological and structural properties were investigated. The polysaccharide yield reached around 40.8 g/L for 48 h of fermentation. The purified exopolysaccharide was an \u03b1-d-glucan with the molecular weight of 2.50 \u00d7 10<sup>7</sup> g/mol. Thermal analysis showed the exopolysaccharide broke down above 200 \u00b0C, the weight dramatically lost (around 53.0%) from 230 to 340 \u00b0C and the melting point was 147.7 \u00b0C with the enthalpy value of 78.4 J/g. The glucan solution (3.0-9.0%, v/w) has an opalescent, milky-white color and the concentration affected the depth of color. The viscosity increased rapidly with concentration in the range of 3.0-20% (w/v) with relatively high viscosity as well as poor solubility at a concentration higher than 20% (w/v). The solution also exhibited the non-Newtonian pseudoplastic behavior with increasing shear rate from 0.01 to 100 l/s. This glucan had a high viscosity in solution and this could make it suitable for usage as gum substitute in some processing food.",
        "keywords": [
            "Homopolysaccharide",
            "Lactobacillus reuteri SK24.003",
            "Rheological characteristic",
            "Thermal property",
            "Three-dimensional molecular model"
        ],
        "venue": "Carbohydrate Polymers",
        "year": 2015,
        "id": "VSEIC00X"
    },
    "MJLwRZbK": {
        "authors": [
            {
                "name": "Binlin Dou",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Bo Jiang",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Yongchen Song",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Chuan Zhang",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Chao Wang",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Haisheng Chen",
                "org": "Institute of Engineering Thermophysics"
            },
            {
                "name": "Baoguo Du",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Yujie Xu",
                "org": "Institute of Engineering Thermophysics"
            }
        ],
        "title": "Enhanced hydrogen production by sorption-enhanced steam reforming from glycerol with in-situ CO",
        "abstract": "For the fixed-bed reactor configuration in the sorption-enhanced steam reforming process (SERP), solid mixture of catalyst and sorbent is stationary and alternatively exposed to reaction and regeneration conditions for multi-cycles by periodically switching the feed gases for enhanced hydrogen production with in-situ CO",
        "keywords": [
            "CaO based sorbent",
            "Glycerol",
            "Ni-based catalyst",
            "Sorption-enhanced steam reforming process (SERP)"
        ],
        "venue": "Fuel",
        "year": 2016,
        "id": "MJLwRZbK"
    },
    "YruQJs65": {
        "authors": [
            {
                "name": "Shuhuai Yu",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University"
            },
            {
                "name": "Xiao Wang",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University"
            },
            {
                "name": "Bo Jiang",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Wanmeng Mu",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            }
        ],
        "title": "Characterization of a thermostable inulin fructotransferase from Clostridium clostridioforme AGR2157 that produces difructose dianhydride i from inulin",
        "abstract": "A gene encoding a difructose dianhydride I (DFA I)-forming inulin fructotransferase (IFTase) from Clostridium clostridioforme AGR2157 was cloned and extracellularly expressed in Escherichia coli. SDS-PAGE and gel filtration analysis of the purified enzyme showed molecular mass of 43 and 128 kDa, respectively, indicating that the recombinant enzyme was a trimer with three identical subunits. The enzyme displayed the highest activity at pH 5.5 and 50 \u00b0C with the specific activity of 2.076 U mg<sup>-1</sup>, and it was stable under heat treatment of up to 80 \u00b0C for 4 h. In comparison with other reported IFTases (DFA I-forming), the recombinant IFTase from C. clostridioforme demonstrated the best thermostability. K<inf>m</inf> and V<inf>max</inf> were calculated to be 0.42 mM and 2.69 mM min<sup>-1</sup>, respectively. The main product of the hydrolysis of inulin by purified enzyme was identified as DFA I according to nuclear magnetic resonance analysis, and the minor products were suggested to be sucrose (GF), 1-kestose (GF<inf>2</inf>), nystose (GF<inf>3</inf>), and fructofuranosyl nystose (GF<inf>4</inf>). The smallest fructo-oligosaccharide substrate was determined to be GF<inf>3</inf>. When 10, 50, and 100 g L<sup>-1</sup> of inulin were catalyzed by the purified enzyme, the maximal yields of DFA I were approximately 85%, 73%, and 71%, respectively.",
        "keywords": [
            "Clostridium clostridioforme",
            "Difructose dianhydride I",
            "Inulin fructotransferase",
            "Thermostability"
        ],
        "venue": "Journal of Molecular Catalysis B: Enzymatic",
        "year": 2015,
        "id": "YruQJs65"
    },
    "wQhy4W8c": {
        "authors": [
            {
                "name": "Ming Miao",
                "org": ""
            },
            {
                "name": "Xue Jia",
                "org": ""
            },
            {
                "name": "Bo Jiang",
                "org": ""
            },
            {
                "name": "Shengfang Wu",
                "org": ""
            },
            {
                "name": "Steve W. Cui",
                "org": ""
            },
            {
                "name": "Xingfeng Li",
                "org": ""
            }
        ],
        "title": "Elucidating molecular structure and prebiotics properties of bioengineered \u03b1-D-glucan from Leuconostoc citreum SK24.002",
        "abstract": "The objective of this work was to produce the bioengineered \u03b1-D-glucan from Leuconostoc citreum SK24.002 and study its molecular structure and prebiotics properties. The connectivities and substitutions of \u03b1-D-glucan were measured using 2D NMR and the chain structure of the repeating unit was deduced. During in vitro fecal fermentation, a strong increase in bacterial population was observed and the largest changes took place during the first 24 h of incubation. A decrease pH (approximately 2.0) was also observed for the fermentation from 0 h to 48 h compared to the blank (pH 6.8-6.6). Total short-chain fatty acid (SCFA) increased during batch fecal fermentation in the presence of \u03b1-D-glucan and it reached the maximum level of 30.01 mM after 48 h of fermentation. The lowest gas production and highest butyric acid production at 48 h of incubation was recorded with \u03b1-D-glucan as compared with dextran or pullulan. Moreover, human fecal microbiota on \u03b1-D-glucan produced more butyric acid between 24 and 48 h than other test carbohydrates. These results suggest that \u03b1-D-glucan would be a good candidate slowly fermentable fiber and may have a positive effect for the gut microbiota homeostasis.",
        "keywords": [
            "Chain structure",
            "In vitro fecal fermentation",
            "Leuconostoc citreum SK24.002",
            "Prebiotics property",
            "\u03b1-D-glucan"
        ],
        "venue": "Food Hydrocolloids",
        "year": 2016,
        "id": "wQhy4W8c"
    },
    "SgY7TsOc": {
        "authors": [
            {
                "name": "Wenli Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University"
            },
            {
                "name": "Hao Li",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University"
            },
            {
                "name": "Bo Jiang",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Leon Zhou",
                "org": "Roquette America"
            },
            {
                "name": "Wanmeng Mu",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            }
        ],
        "title": "Characterization of a D-psicose 3-epimerase from Dorea sp. CAG317 with an acidic pH optimum and a high specific activity",
        "abstract": "Ketose 3-epimerase displayed an important role in not only the cyclic monosaccharides bioconversion strategy, named Izumoring, but also in the industrial biological production of D-psicose, a novel low-calorie rare sugar widely used in food and medical industries. Since the non-enzymatic side reactions could be reduced in acid conditions, slightly acidic pH optimum is one of the main issues for biological production of D-psicose. In this study, we first characterized an acidic ketose 3-epimerase, the recombinant D-psicose 3-epimerase (DPEase) from Dorea sp. CAG317. The protein exhibited high amino acid sequence identity with other reported DPEases, and was determined as a homotetramer with subunit molecular weight approximately 33 kDa, which was the same as other reported findings. The recombinant DPEase was a metal-dependent enzyme with the optimum metal cofactor as Co<sup>2+</sup>. In presence of 1 mM of Co<sup>2+</sup>, the enzyme displayed the maximal activity as 803 U/mg at pH 6.0 and 70 \u00b0C. The catalytic efficiency (k<inf>cat</inf>/K<inf>m</inf>) was measured to be 412 and 199 mM<sup>-1</sup> min<sup>-1</sup> toward D-psicose and D-fructose, respectively. The equilibrium ratio between D-fructose and D-psicose was approximately 30:70, and the elevated temperature did not significantly shift the equilibrium toward D-psicose. Compared to other reported DPEases, the recombinant Dorea sp. DPEase displayed significantly higher specific activity at acidic pHs and remarkably higher productivity of D-psicose at pH 6.0, indicating that it was appropriate for use as a new source of D-psicose producing enzyme.",
        "keywords": [
            "Acidic pH optimum",
            "D-Psicose",
            "D-Psicose 3-epimerase",
            "Dorea sp. CAG317",
            "Rare sugar"
        ],
        "venue": "Journal of Molecular Catalysis B: Enzymatic",
        "year": 2015,
        "id": "SgY7TsOc"
    },
    "oEE3OInw": {
        "authors": [
            {
                "name": "Shaohua Zuo",
                "org": ""
            },
            {
                "name": "Tao Zhang",
                "org": ""
            },
            {
                "name": "Bo Jiang",
                "org": ""
            },
            {
                "name": "Wanmeng Mu",
                "org": ""
            }
        ],
        "title": "Reduction of acrylamide level through blanching with treatment by an extremely thermostable l-asparaginase during French fries processing",
        "abstract": "Bacterial l-asparaginase catalyzes the hydrolysis of l-asparagine to l-aspartic acid. It is normally used as an antineoplastic drug applied in lymphoblastic leukemia chemotherapy and as a food processing aid in baked or fried food industry to inhibit the formation of acrylamide. The present study demonstrates cloning, expression, and characterization of a thermostable l-asparaginase from Thermococcus zilligii AN1 TziAN1_1 and also evaluates the potential for enzymatic acrylamide mitigation in French fries using this enzyme. The recombinant l-asparaginase was purified to homogeneity by nickel-affinity chromatography. The purified enzyme displayed the maximum activity at pH 8.5 and 90\u00a0\u00b0C, and the optimum temperature was the highest ever reported. The K<inf>m</inf>, k<inf>cat</inf>, and k<inf>cat</inf>/K<inf>m</inf> values toward l-asparagine were measured to be 6.08\u00a0mM, 3267\u00a0s<sup>\u22121</sup>, and 537.3\u00a0mM<sup>\u22121</sup>\u00a0s<sup>\u22121</sup>, respectively. The enzyme retained 70\u00a0% of its original activity after 2\u00a0h of incubation at 85\u00a0\u00b0C. When potato samples were treated with 10\u00a0U/mL of l-asparaginase at 80\u00a0\u00b0C for only 4\u00a0min, the acrylamide content in final French fries was reduced by 80.5\u00a0% compared with the untreated control. Results of this study revealed that the enzyme was highly active at elevated temperatures, reflecting the potential of the T. zilligiil-asparaginase in the food processing industry.",
        "keywords": [
            "Acrylamide",
            "Blanching",
            "French fries",
            "l-Asparaginase",
            "Thermococcus zilligii"
        ],
        "venue": "Extremophiles",
        "year": 2015,
        "id": "oEE3OInw"
    },
    "GPFqRfpi": {
        "authors": [
            {
                "name": "Wanmeng Mu",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Lina Yu",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University"
            },
            {
                "name": "Wenli Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Ministry of Education, Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University"
            },
            {
                "name": "Bo Jiang",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            }
        ],
        "title": "Isomerases for biotransformation of D-hexoses",
        "abstract": "Monosaccharides are polyhydroxyl compounds containing several chiral carbons, giving rise to tens of isomeric forms. Only minority of them are natural carbohydrates existing in nature abundantly, and most of them are rarely in nature, called rare sugars. These rare sugars attract increasing attention because of their low-calorie property and promising beneficial effects. Izumoring strategy has been established for linking all monosaccharides by three types of enzymes including ketose 3-epimerases, polyol dehydrogenases, and aldose isomerases. Recently, more attention has been paid on the Izumoring of hexoses, especially the D-zone hexoses. So far, at least ten isomerases have been used for the isomerization reactions between D-aldohexoses and D-ketohexoses. In this article, the interconnections and potential physiological effects of D-ketohexoses and D-aldohexoses are summarized, the D-zone hexose Izumoring is shown by giving the exact biocatalysts, and importantly, the isomerases for D-hexose biotransformation are reviewed in detail.",
        "keywords": [
            "Aldose isomerase",
            "Biotransformation",
            "Hexose",
            "Monosaccharide",
            "Rare sugar"
        ],
        "venue": "Applied Microbiology and Biotechnology",
        "year": 2015,
        "id": "GPFqRfpi"
    },
    "E9jmSDlm": {
        "authors": [
            {
                "name": "Qing Meng",
                "org": "State Key Laboratory of Food Science and Technology, Jiangnan University"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Jiangnan University"
            },
            {
                "name": "Bo Jiang",
                "org": "State Key Laboratory of Food Science and Technology, Jiangnan University"
            },
            {
                "name": "Wanmeng Mu",
                "org": "State Key Laboratory of Food Science and Technology, Jiangnan University"
            },
            {
                "name": "Ming Miao",
                "org": "State Key Laboratory of Food Science and Technology, Jiangnan University"
            }
        ],
        "title": "Advances in applications, metabolism, and biotechnological production of L-xylulose",
        "abstract": "L-Xylulose is an intermediate in certain metabolic pathways and is classified as a rare sugar. It shows important physiological effects such as acting as an inhibitor of \u03b1-glucosidase and decreasing blood glucose, and it can be employed to produce other significant rare sugars, such as L-ribose and L-xylose which contribute to the production of antiviral drugs. Chemical synthesis of L-xylulose was performed, but it is difficult and low yielding. The biotransformation from xylitol to L-xylulose by xylitol 4-dehydrogenase was studied intensively. This review describes the occurrence of L-xylulose in certain metabolic pathways, its bioproduction, and application potential.",
        "keywords": [
            "Application potential",
            "Bioproduction",
            "L-Xylulose",
            "Metabolic pathways",
            "Rare sugar"
        ],
        "venue": "Applied Microbiology and Biotechnology",
        "year": 2015,
        "id": "E9jmSDlm"
    },
    "oRDACyEH": {
        "authors": [
            {
                "name": "Chao Huang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Ming Miao",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Srinivas Janaswamy",
                "org": "Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University"
            },
            {
                "name": "Bruce R. Hamaker",
                "org": "Whistler Center for Carbohydrate Research, Department of Food Science, Purdue University"
            },
            {
                "name": "Xingfeng Li",
                "org": "College of Bioscience and Bioengineering, Hebei University of Science and Technology"
            },
            {
                "name": "Bo Jiang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            }
        ],
        "title": "Polysaccharide Modification through Green Technology: Role of Endodextranase in Improving the Physicochemical Properties of (1\u21923)(1\u21926)-\u03b1-D-Glucan",
        "abstract": "The structure and properties of bioengineered (1\u21923)(1\u21926)-\u03b1-D-glucan subjected to endodextranase treatment were investigated. Upon enzyme treatment, OD<inf>220</inf> and M<inf>w</inf> decreased substantially during the first 60 min and thereafter slowed as the modification progressed. Compared to the native glucan, the modified sample solution had a lighter opalescent, bluish-white color. The morphological analysis revealed that bioengineered glucan produced quite a few small particles after hydrolysis. The molecular weight distribution curve gradually shifted to the low M<inf>w</inf> region with a significant broadening distribution, and the chain hydrolysis reaction followed a combination of zeroth- and first-order processes. The NMR results showed some specific \u03b1-1,6 linkages of glucan chains were cleaved with enzyme treatment. The viscosity of modified glucan solution was markedly reduced, and the Newtonian plateaus were also observed at high shear rates (10-100 1/s). The above results suggested that the modified (1\u21923)(1\u21926)-\u03b1-D-glucan showed a tailor-made solution character similar to that of arabic gum and would be used as a novel food gum substitute in the design of artificial carbohydrate-based foods.",
        "keywords": [
            "branched structure",
            "enzymatic hydrolysis",
            "kinetic model",
            "molecular weight",
            "rheology",
            "\u03b1-D-glucan"
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2015,
        "id": "oRDACyEH"
    },
    "B3V5cnC7": {
        "authors": [
            {
                "name": "Ming Miao",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Yajun Ma",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Bo Jiang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Steve W. Cui",
                "org": "Guelph Food Research Centre, Agriculture and Agri-Food Canada"
            },
            {
                "name": "Shengfang Wu",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University"
            }
        ],
        "title": "Structural elucidation and in vitro fermentation of extracellular \u03b1-d-glucan from Lactobacillus reuteri SK24.003",
        "abstract": "The molecular structure and its relationship to in vitro fermentation properties of \u03b1-d-glucan from Lactobacillus reuteri SK24.003 were investigated in this study. The chain structure was elucidated by 2D NMR spectroscopy and a possible repeating unit was deduced. During in vitro fecal fermentation, the relatively low initial bacterial population was observed during first 6 h incubation and small increase for \u03b1-d-glucan for 12-48 h incubation. A significant decrease in pH (approximately 2.0) was observed for fecal microbiota exposed to \u03b1-d-glucan. Acetic acid, propionic acid, n-butyric acid along with total short-chain fatty acid (SCFA) increased upon incubation, and d-glucan was initially fermented well resulting in the higher production of SCFA at 12 h. The n-butyric acid value at 48 h fermentation (1.29 mM) was higher than that of some commercial prebiotic oilosaccharides. These results suggested that \u03b1-d-glucan might be efficiently utilized by gut bacteria and may have a positive effect for gastrointestinal health.",
        "keywords": [
            "In vitro fecal fermentation",
            "Lactobacillus reuteri SK24.003",
            "Molecular fine structure",
            "Short-chain fatty acid",
            "\u03b1-d-glucan"
        ],
        "venue": "Bioactive Carbohydrates and Dietary Fibre",
        "year": 2015,
        "id": "B3V5cnC7"
    },
    "gmDsManJ": {
        "authors": [
            {
                "name": "Wenjing Li",
                "org": "State Key Laboratory of Food Science and Technology"
            },
            {
                "name": "Shuhuai Yu",
                "org": "State Key Laboratory of Food Science and Technology"
            },
            {
                "name": "Tao Zhang",
                "org": "State Key Laboratory of Food Science and Technology"
            },
            {
                "name": "Bo Jiang",
                "org": "Synergetic Innovation Center of Food Safety and Nutrition"
            },
            {
                "name": "Timo Stressler",
                "org": "University of Hohenheim"
            },
            {
                "name": "Lutz Fischer",
                "org": "University of Hohenheim"
            },
            {
                "name": "Wanmeng Mu",
                "org": "University of Hohenheim"
            }
        ],
        "title": "Efficient Biosynthesis of Lactosucrose from Sucrose and Lactose by the Purified Recombinant Levansucrase from Leuconostoc mesenteroides B-512 FMC",
        "abstract": "Lactosucrose, a rare trisaccharide formed from sucrose and lactose by enzymatic transglycosylation, is a type of indigestible carbohydrate with a good prebiotic effect. In this study, lactosucrose biosynthesis was efficiently carried out by a purified levansucrase from Leuconostoc mesenteroides B-512. The target gene was cloned and expressed in Escherichia coli, and the recombinant enzyme was purified to homogeneity by nickel affinity and gel filtration chromatography. The effects of pH, temperature, substrate concentration, substrate ratio, and enzyme amount on lactosucrose biosynthesis were studied in detail, and the optimized conditions were determined to be pH 6.5, 50 \u00b0C, 27% (W/V) sucrose, 27% (W/V) lactose, and 5 U mL",
        "keywords": [
            "lactosucrose",
            "Leuconostoc mesenteroides",
            "levansucrase",
            "prebiotic",
            "transfructosylation"
        ],
        "venue": "Journal of Agricultural and Food Chemistry",
        "year": 2015,
        "id": "gmDsManJ"
    },
    "plLuJNGK": {
        "authors": [
            {
                "name": "Kebiao Mao",
                "org": "State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences and Beijing Normal University"
            },
            {
                "name": "Ying Ma",
                "org": "International Agricultural Big Data and Nutrition Research Institute in China"
            },
            {
                "name": "Xinyi Shen",
                "org": "Hydrometeorology and Remote Sensing Laboratory, The University of Oklahoma"
            },
            {
                "name": "Lang Xia",
                "org": "National Hulunber Grassland Ecosystem Observation and Research Station, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Shiying Tian",
                "org": "National Hulunber Grassland Ecosystem Observation and Research Station, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Jiaqi Han",
                "org": "National Hulunber Grassland Ecosystem Observation and Research Station, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences"
            },
            {
                "name": "Qing Liu",
                "org": "National Hulunber Grassland Ecosystem Observation and Research Station, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences"
            }
        ],
        "title": "A method for retrieving soil moisture from GNSS-R by using experiment data",
        "abstract": "Soil moisture is a key parameter in agricultural irrigation. The L band (1.58 GHz) on board global position system (GPS) satellite is well suited for monitoring the change of soil moisture. In order to investigate the potential of retrieving soil moisture using the L-band GPS bistatic radar, this paper analyzed a retrieval method by using field experiment data. In order to investigate the relationship between the soil moisture (corresponding roughly to the 0~5 cm top soil layer) and the signal-to-noise ratio (P<inf>r-SNR</inf>) to the direct GPS signal-to-noise ratio (P<inf>d-SNR</inf>), an experiment was conducted in Hulunber grassland of China in 2009 and 2011. Six field sites in the soil moisture experiment were utilized to analyze the relationship between soil moisture and the ratio of P<inf>r-SNR</inf> to P<inf>d-SNR</inf> and the square of correlation coefficient was about 0.9 when the surface type was known and the elevation angle of the satellite ranged from 65 to 85 degrees approximately. The analysis shows that ratio of P<inf>r-SNR</inf> to P<inf>d-SNR</inf> can be used to monitor the soil moisture, because the ratio of P<inf>r-SNR</inf> to P<inf>d-SNR</inf> maximized the elimination of the influence of different signals from different GPS satellites. The estimation accuracy could be improved if we make full use of the empirical knowledge on elevation angles of GPS satellites and ground roughness of different surface types.",
        "keywords": [
            "Global navigation satellite system-reflection (GNSS-R)",
            "Global position system (GPS)",
            "Soil moisture"
        ],
        "venue": "High Technology Letters",
        "year": 2015,
        "id": "plLuJNGK"
    },
    "fRFmyisV": {
        "id": "fRFmyisV",
        "title": "Short-term Optimized Scheduling Combined of Cascade Hydropower Group",
        "abstract": "The genetic algorithm is a kind of simple and applicable search method which is used for solving nonlinear complicated problem.The optimal scheduling problem of reservoirs group is a kind of simplified general mathematical model used the search algorithm.According to the condition of inlet and outlet water and comprehensive utilization of reservoir group,the hydropower station is seen as a system,each element of the system and input/output parameters are simplified and assumptions,establishing the mathematical model later,search algorithm is used to optimize the mathematical model for simulation,and the optimal solution is obtained.",
        "keywords": [
            "genetic algorithms",
            "cascade reservoirs group",
            "optimal scheduling",
            "Matlab toolbox"
        ],
        "authors": [
            {
                "name": "WANG Peng-fei",
                "org": "Hebei University of Engineering,Handan ,China"
            },
            {
                "name": "WANG Yu-qing",
                "org": "Hebei University of Engineering,Handan ,China"
            },
            {
                "name": "LIU Feng",
                "org": "Air Force 94287 Troops,Weihai ,China"
            }
        ],
        "venue": "Water Sciences and Engineering Technology",
        "year": 2011
    },
    "xQopOWAk": {
        "id": "xQopOWAk",
        "title": "Research on temperature fields of governing stage for steam turbine based on finite element analysis",
        "abstract": "Aiming at the characteristics of steam turbine start-up and shut-down and varying load condition course,the biggish temperature grads of main components will be produced and the unit's life loss will be also increased.The theory of finite element was used in this paper to simulate the temperature fields of governing stage for steam turbine,so that both the theoretical basis for modeling on each unit of the steam turbine and rotor's temperature field were provided,the thermal stress analysis was carried out and the reference for optimization of turbine start-up was also provided.",
        "keywords": [
            "steam turbine",
            "governing stage",
            "ANSYS",
            "temperature fields"
        ],
        "authors": [
            {
                "name": "WANG Yu-qing",
                "org": "College of Hydraulics and Electric Power,Hebei University of Engineering,Handan ,China"
            },
            {
                "name": "WANG Peng-fei",
                "org": "College of Hydraulics and Electric Power,Hebei University of Engineering,Handan ,China"
            },
            {
                "name": "LIU Feng",
                "org": "College of Hydraulics and Electric Power,Hebei University of Engineering,Handan ,China"
            }
        ],
        "venue": "Energy Conservation",
        "year": 2011
    },
    "2KIZ7Tvl": {
        "authors": [
            {
                "name": "Qingfeng Liu",
                "org": ""
            },
            {
                "name": "Huamiao Song",
                "org": ""
            },
            {
                "name": "Yi Du",
                "org": ""
            },
            {
                "name": "Zhengtao Cao",
                "org": ""
            },
            {
                "name": "Yubin Zhou",
                "org": ""
            },
            {
                "name": "Fei Peng",
                "org": ""
            },
            {
                "name": "Liu Yang",
                "org": ""
            },
            {
                "name": "Lei Yang",
                "org": ""
            },
            {
                "name": "Yongchang Luo",
                "org": ""
            }
        ],
        "title": "Effect of deep-breath biofeedback on heart rate variability and blood pressure at high altitude",
        "abstract": "The objective of this study is to study the effect of deep respiration on heart rate variability and blood pressure at high altitude. Methods: Experiments were conducted in 74 male military operators who have been deployed to 3,780-m-high altitude for 60 days. Heart rate variability and blood pressure were monitored at rest state and deep-breath biofeedback state. Result: Heart rate of deep-breath biofeedback was significantly lower than that of the rest (t = 2.01, P = 0.043). SDNN and LF were significantly higher (t = 3.70, 5.40, P < 0.001). There was no difference in HF (P > 0.05).Both systolic pressure and diastolic pressure of biofeedback state were significantly lower (t = 4.06, 7.63, P < 0.001). Conclusion: Deep-breath biofeedback can increase heart rate variability and reduce heart rate and blood pressure in high altitude. It is an important assistant method used to acclimatize high altitude which can bring positive psychophysiological change to military operators. \u00a9 2014 Springer-Verlag.",
        "keywords": [
            "Biofeedback",
            "Blood pressure",
            "Deep-breath",
            "Heart rate variability",
            "Hypoxia",
            "Military"
        ],
        "venue": "Lecture Notes in Electrical Engineering",
        "year": 2014,
        "id": "2KIZ7Tvl"
    },
    "HIhV8uzf": {
        "id": "HIhV8uzf",
        "title": "Defeating Untrustworthy Testing Parties: A Novel Hybrid Clustering Ensemble Based Golden Models-Free Hardware Trojan Detection Method.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Mingfu Xue",
                "org": ""
            },
            {
                "name": "Rongzhen Bian",
                "org": ""
            },
            {
                "name": "Weiqiang Liu",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "IEEE Access",
        "year": 2019
    },
    "dmB3z0og": {
        "id": "dmB3z0og",
        "title": "A Co-training Based Hardware Trojan Detection Technique by Exploiting Unlabeled ICs and Inaccurate Simulation Models.",
        "abstract": "Integrated circuits (ICs) are becoming vulnerable to hardware Trojans. Most of existing works require golden chips to provide references for hardware Trojan detection. However, a golden chip is extremely difficult to obtain. In previous work, we have proposed a classification-based golden chips-free hardware Trojan detection technique. However, the algorithm in the previous work are trained by simulated ICs without considering that there may be a shift which occurs between the simulation and the silicon fabrication. It is necessary to learn from actual silicon fabrication in order to obtain an accurate and effective classification model. We propose a co-training based hardware Trojan detection technique exploiting unlabeled fabricated ICs and inaccurate simulation models, to provide reliable detection capability when facing fabricated ICs, while eliminating the need of fabricated golden chips. First, we train two classification algorithms using simulated ICs. During test-time, the two algorithms can identify different patterns in the unlabeled ICs, and thus be able to label some of these ICs for the further training of the another algorithm. Moreover, we use a statistical examination to choose ICs labeling for the another algorithm in order to help prevent a degradation in performance due to the increased noise in the labeled ICs. We also use a statistical technique for combining the hypotheses from the two classification algorithms to obtain the final decision. The theoretical basis of why the co-training method can work is also described. Experiment results on benchmark circuits show that the proposed technique can detect unknown Trojans with high accuracy (92%~97%) and recall (88%~95%).",
        "keywords": "",
        "authors": [
            {
                "name": "Mingfu Xue",
                "org": "Nanjing University of Aeronautics and Astronautics"
            },
            {
                "name": "Rongzhen Bian",
                "org": "Nanjing University of Aeronautics and Astronautics"
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Weiqiang Liu",
                "org": "Nanjing University of Aeronautics and Astronautics"
            }
        ],
        "venue": "TrustCom/BigDataSE",
        "year": 2018
    },
    "SMgymAs5": {
        "id": "SMgymAs5",
        "title": "Building Trusted Golden Models-Free Hardware Trojan Detection Framework Against Untrustworthy Testing Parties Using a Novel Clustering Ensemble Technique.",
        "abstract": "As a result of the globalization of integrated circuits (ICs) design and fabrication process, ICs are becoming vulnerable to hardware Trojans. Most of the existing hardware Trojan detection works suppose that the testing stage is trustworthy. However, testing parties may conspire with malicious attackers to modify the results of hardware Trojan detection. In this paper, we propose a trusted and robust hardware Trojan detection framework against untrustworthy testing parties exploiting a novel clustering ensemble method. The proposed technique can expose the malicious modifications on Trojan detection results introduced by untrustworthy testing parties. Compared with the state-of-the-art detection methods, the proposed technique does not require fabricated golden chips or simulated golden models. The experiment results on ISCAS89 benchmark circuits show that the proposed technique can resist modifications robustly and detect hardware Trojans with decent accuracy (up to 91%).",
        "keywords": "",
        "authors": [
            {
                "name": "Rongzhen Bian",
                "org": "Nanjing University of Aeronautics and Astronautics"
            },
            {
                "name": "Mingfu Xue",
                "org": "Nanjing University of Aeronautics and Astronautics"
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "TrustCom/BigDataSE",
        "year": 2018
    },
    "mlaZ0WnE": {
        "id": "mlaZ0WnE",
        "title": "An enhanced classification-based golden chips-free hardware Trojan detection technique.",
        "abstract": "Recently, integrated circuits (ICs) are becoming increasing vulnerable to hardware Trojans. Most of existing works require golden chips to provide references for hardware Trojan detection. However, obtaining a golden chip is extremely difficult or even not exists. This paper presents a novel automated hardware Trojan detection technique based on enhanced two-class classification while eliminating the need of golden chips after fabrication. We formulate the Trojan detection problem into a classification problem, and train the algorithms using simulated ICs during IC design flow. The algorithm will form a classifier which can automatically identify Trojan-free and Trojan-inserted ICs during test-time. Moreover, we propose several optional optimized methods to enhance the technique: 1) we propose adaptive iterative optimization of one algorithm by focusing on errors, in which the weight-adjusting are based on how successful the algorithm was in the previous iteration; 2) we analyze the misclassified ICsu0027 numbers of certain algorithms and present the matched algorithm-pairs; 3) we alter the algorithms to take into account of the costs of making different detection decisions, called cost-sensitive detection; 4) we present the suitable algorithm settings against high level of process variations. Experiment results on benchmark circuits show that the proposed technique can detect both known Trojans and various unknown Trojans with high accuracy and recall (90%\u223c100%). Since we didnu0027t add any extra circuit to the design, there is no overhead of this approach.",
        "keywords": "",
        "authors": [
            {
                "name": "Mingfu Xue",
                "org": "College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, 210016, China"
            },
            {
                "name": "Jian Wang",
                "org": "College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, 210016, China"
            },
            {
                "name": "Aiqun Hu",
                "org": "School of Information Science and Engineering, Southeast University, Nanjing, 210096, China"
            }
        ],
        "venue": "AsianHOST",
        "year": 2016
    },
    "B6yLFfEA": {
        "id": "B6yLFfEA",
        "title": "Building an Accurate Hardware Trojan Detection Technique from Inaccurate Simulation Models and Unlabeled ICs",
        "abstract": "Most of prior hardware Trojan detection approaches require golden chips for references. A classification-based golden chips-free hardware Trojan detection technique has been proposed in the authors\u2019 previous work. However, the algorithm in that work is trained by simulated ICs without considering a shift between the simulation and silicon fabrication. In this study, a co-training based hardware Trojan detection method by exploiting inaccurate simulation models and unlabeled fabricated ICs is proposed to provide reliable detection capability when facing fabricated ICs, which eliminates the need of golden chips. Two classification algorithms are trained using simulated ICs. These two algorithms can identify different patterns in the unlabelled ICs during test-time, and thus can label some of these ICs for the further training of the other algorithm. Moreover, a statistical examination is used to choose ICs labelling for the other algorithm. A statistical confidence interval based technique is also used to combine the hypotheses of the two classification algorithms. Furthermore, the partial least squares method is used to preprocess the raw data of ICs for feature selection. Both EDA experiment results and field programmable gate array (FPGA) experiment results show that the proposed technique can detect unknown Trojans with high accuracy and recall.",
        "keywords": [
            "embedded systems",
            "invasive software",
            "field programmable gate arrays",
            "pattern classification",
            "electronic design automation"
        ],
        "authors": [
            {
                "name": "Mingfu Xue",
                "org": ""
            },
            {
                "name": "Rongzhen Bian",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Weiqiang Liu",
                "org": ""
            }
        ],
        "venue": "Iet Computers and Digital Techniques",
        "year": 2019
    },
    "mqMfjeZ6": {
        "id": "mqMfjeZ6",
        "title": "Security Against Hardware Trojan Attacks Through a Novel Chaos FSM and Delay Chains Array PUF Based Design Obfuscation Scheme.",
        "abstract": "Hardware Trojan has emerged as a major security concern for integrated circuits. This paper presents a novel design obfuscation scheme against hardware Trojan attacks based on chaos finite state machine (FSM) and delay chains array physical unclonable function (PUF). We exploits the pseudo-random characteristics of the M-sequences to propose a chaos FSM design method which can generate exponentially many random states and transitions to obfuscate the chip\u2019s functional states with low overhead. The chip\u2019s functionalities are locked and obfuscated and would not be functional without a unique key that can only be computed by the designer. We also propose a new PUF construction method, named delay chains array PUF (DAPUF), to extract the unique power-up state for each chip which is corresponding to a unique key sequence. We introduce confusions between delay chains to achieve avalanche effects of the PUF outputs. Thus the proposed DAPUF approach can provide large number of PUF instances with high accuracy and reverse-engineering resistant. Through the proposed obfuscation scheme, the designer can control the IC\u2019s operation modes (chaos mode and normal mode) and functionalities, and can also remotely disable the chips when hardware Trojan insertion is revealed. The functional obfuscation prevents the adversary from understanding the real functionalities of the circuit as well as the real rare events in the internal nodes, thus making it difficult for the adversary to insert hard-to-detect Trojans. It also makes the inserted Trojans become invalid since the Trojans are most likely inserted in the chaos mode and will be activated only in the chaos mode. Both simulation experiments on benchmark circuits and hardware evaluations on FPGA show the security, low overhead and practicality of the proposed method.",
        "keywords": [],
        "authors": [
            {
                "name": "Mingfu Xue",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Youdong Wang",
                "org": ""
            },
            {
                "name": "Aiqun Hu",
                "org": ""
            }
        ],
        "venue": "ICCCS",
        "year": 2015
    },
    "d2IsaCRr": {
        "id": "d2IsaCRr",
        "title": "Automated Vulnerability Modeling and Verification for Penetration Testing Using Petri Nets.",
        "abstract": "With the increase of network size, there are more and more potential vulnerabilities, which makes it difficult to conduct penetration testing in multihost networks. Attack graph is a useful tool for penetration testing to analyze the relevance of vulnerabilities between hosts and provides a visual view for attack path planning. However, previous works on attack graph generation are inefficient and not applicable to practical penetration testing process. In this paper, we propose an automated vulnerability modeling and verification approach for penetration testing, which generates attack graph efficiently and can be applied to attack process. Petri net is adopted for vulnerability modeling and attack graph synthesis. We implement a prototype system named Automatic Penetration Testing System to verify our method. The system is tested in real networks and the experiment results show the efficiency of our approach.",
        "keywords": "",
        "authors": [
            {
                "name": "Junchao Luan",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Mingfu Xue",
                "org": ""
            }
        ],
        "venue": "ICCCS",
        "year": 2016
    },
    "saQFx5bU": {
        "id": "saQFx5bU",
        "title": "A Novel Golden Models-Free Hardware Trojan Detection Technique Using Unsupervised Clustering Analysis.",
        "abstract": "Recently, hardware Trojan has become a major threat for integrated circuits. Most of the existing hardware Trojan detection works require golden chips or golden models for reference. However, a golden chip is extremely difficult to obtain or even does not exist. In this paper, we propose a novel hardware Trojan detection technique using unsupervised clustering techniques. The unsupervised clustering technique can obtain the structure information of the set of unlabeled ICs, and then distinguishes the suspicious ICs from the ICs under test. We formulate the unsupervised hardware Trojan detection problem into two types of detection models: partitioning-based and density-based detection model. We also propose a novel metric to determine the labels of the clusters. Compared with the state-of-the-art detection methods, the proposed technique can work in an unsupervised scenario with no need of ICs\u2019 prior information. It does not require fabricated golden chips or golden models. We perform simulation evaluation on ISCAS89 benchmarks and FPGA evaluation on Trust-HUB benchmarks. Both evaluation results show that the proposed technique can detect infected ICs in the unsupervised scenario with a good accuracy.",
        "keywords": "",
        "authors": [
            {
                "name": "Rongzhen Bian",
                "org": ""
            },
            {
                "name": "Mingfu Xue",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            }
        ],
        "venue": "ICCCS",
        "year": 2018
    },
    "WOUxDE1g": {
        "id": "WOUxDE1g",
        "title": "A systems biology strategy on differential gene expression data discloses some biological features of atrial fibrillation.",
        "abstract": "Atrial fibrillation (AF), the most common cardiac arrhythmia, is associated with extensive structural, contractile, and electrophysiological remodeling. In this manuscript we re-analyzed gene expression data from a microarray experiment on AF patients and control tissues, using a new paradigm based on a posteriori unsupervised strategy in which the discrimination of patients comes out from purely syntactical premises. This paradigm, more adherent to biological reality where genes work in highly connected networks, allowed us to get both a very precise patients/control discrimination and the discovery of cell adhesion/tissue modeling and inflammation processes as the main dimensions of AF.",
        "keywords": [],
        "authors": [
            {
                "name": "Censi Federica",
                "org": "Department of Technologies and Health, Istituto Superiore di Sanit\u00e0, Rome, Italy. federica.censi@iss.it"
            },
            {
                "name": "Calcagnini Giovanni",
                "org": ""
            },
            {
                "name": "Bartolini Pietro",
                "org": ""
            },
            {
                "name": "Giuliani Alessandro",
                "org": ""
            }
        ],
        "venue": "PloS one",
        "year": 2010
    },
    "By5DtAMd": {
        "id": "By5DtAMd",
        "title": "System Biology Approach: Gene Network Analysis for Muscular Dystrophy.",
        "abstract": "Phenotypic changes at different organization levels from cell to entire organism are associated to changes in the pattern of gene expression. These changes involve the entire genome expression pattern and heavily rely upon correlation patterns among genes. The classical approach used to analyze gene expression data builds upon the application of supervised statistical techniques to detect genes differentially expressed among two or more phenotypes (e.g., normal vs. disease). The use of an a posteriori, unsupervised approach based on principal component analysis (PCA) and the subsequent construction of gene correlation networks can shed a light on unexpected behaviour of gene regulation system while maintaining a more naturalistic view on the studied system.In this chapter we applied an unsupervised method to discriminate DMD patient and controls. The genes having the highest absolute scores in the discrimination between the groups were then analyzed in terms of gene expression networks, on the basis of their mutual correlation in the two groups. The correlation network structures suggest two different modes of gene regulation in the two groups, reminiscent of important aspects of DMD pathogenesis.",
        "keywords": [
            "Gene expression",
            "Gene networks",
            "Muscular dystrophy",
            "Principal component analysis"
        ],
        "authors": [
            {
                "name": "Censi Federica",
                "org": "Department of Cardiovascular, Dysmetabolic and Aging-associated Diseases, Italian National Institute of Health, Viale Regina Elena 299, 00161, Rome, Italy. federica.censi@iss.it."
            },
            {
                "name": "Calcagnini Giovanni",
                "org": "Department of Cardiovascular, Dysmetabolic and Aging-associated Diseases, Italian National Institute of Health, Viale Regina Elena 299, 00161, Rome, Italy."
            },
            {
                "name": "Mattei Eugenio",
                "org": "Department of Cardiovascular, Dysmetabolic and Aging-associated Diseases, Italian National Institute of Health, Viale Regina Elena 299, 00161, Rome, Italy."
            },
            {
                "name": "Giuliani Alessandro",
                "org": "Department of Environment and Health, Italian National Institute of Health, Viale Regina Elena 299, 00161, Rome, Italy."
            }
        ],
        "venue": "Methods in molecular biology (Clifton, N.J.)",
        "year": 2018
    },
    "lOKlmBSm": {
        "id": "lOKlmBSm",
        "title": "Hybrids based on transition metal phosphide (Mn2P, Co2P, Ni2P) nanoparticles and heteroatom-doped carbon nanotubes for efficient oxygen reduction reaction",
        "abstract": "Hybrids based on transition metal phosphide (Mn2P, Co2P, Ni2P) nanoparticles and heteroatom-doped carbon nanotubes were facilely synthesized, and used as efficient oxygen reduction reaction (ORR) catalysts in alkaline solution. Transition metal phosphide nanoparticles formed core/shell structures with graphitic carbon, and the nanoparticles (core) can significantly influence the ORR catalytic activity of the carbon shell. Hybrids based on Co2P and Mn2P decorated heteroatom-doped carbon exhibit excellent ORR catalytic activity with regards to dominant 4e\u2212 process, low over potential, excellent methanol tolerance and durability. In contrast, Ni2P decorated heteroatom-doped carbon shows inferior ORR catalytic activity. The variation of ORR performance mainly derives from the collective effect of the electronegativity and binding energy shift of the transition metals, which would result in a different surface electronic structure of the heteroatom-doped carbon. Low electronegativity and low binding energy shift of the transition metals would lead to strong electron-donating ability of the transition metal phosphide nanoparticles, resulting in the enhanced ORR catalytic activity of the hybrid materials. This work is significant for development of advanced ORR catalysts based on heteroatom-doped carbon via rational design of the structure of hybrid materials.",
        "keywords": [],
        "authors": [
            {
                "name": "kuiyong chen",
                "org": "shanghai jiao tong university"
            },
            {
                "name": "xiaobin huang",
                "org": "shanghai jiao tong university"
            },
            {
                "name": "chaoying wan",
                "org": "international institute of minnesota"
            },
            {
                "name": "hong liu",
                "org": "shanghai jiao tong university"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "HAJ8BYJr": {
        "id": "HAJ8BYJr",
        "title": "Convenient one-pot approach for the preparation of novel atomically thin two-dimensional polymeric nanosheets, and its evolution in aqueous solution",
        "abstract": "",
        "keywords": [
            "polymers",
            "thin films",
            "hydrogen bond",
            "nanostructure"
        ],
        "authors": [
            {
                "name": "kuiyong chen",
                "org": ""
            },
            {
                "name": "chaoying wan",
                "org": ""
            },
            {
                "name": "wei wei",
                "org": ""
            },
            {
                "name": "xiaobin huang",
                "org": ""
            },
            {
                "name": "hong liu",
                "org": ""
            }
        ],
        "venue": "Materials Letters",
        "year": 2015
    },
    "Je6oH4is": {
        "id": "Je6oH4is",
        "title": "A Facile Approach to Generate Cross-Linked Poly(cyclotriphosphazene-co-oxyresveratrol) Nanoparticle with Intrinsically Fluorescence",
        "abstract": "Highly cross-linked and monodisperse polyphosphazene nanoparticles exhibiting strong fluorescence with oxyresvertrol structure was facilely generated via a one-pot prediction polycondensation of hexachlorocyclotriphosphazene and oxyresveratrol. The results reveal that the diameter of the microspheres can be well adjusted (typically in a range from 200 to 400\u00a0nm). Attractively, the as-prepared nanoparticle with oxyresveratrol structure possess outstanding disperse ability in both aqueous and organic media. Moreover, it exhibits significantly enhanced fluorescent intensity and outstanding photobleaching stability under ultraviolet\u2013visible irradiation, owing to the highly cross-linked and organic\u2013inorganic hybrid structure. Due to these superior properties and novelty of our synthesized material, it has shown great potential in application as fluorescent labels, carriers and potent biomaterials in drug delivery.",
        "keywords": [
            "Facile",
            " Oxyresveratrol",
            " Nanoparticle",
            " Fluorescent",
            " Cross-linked",
            " Drug delivery"
        ],
        "authors": [
            {
                "name": "Shiquan Hong",
                "org": "Shanghai Jiao Tong University"
            },
            {
                "name": "Jing Li",
                "org": "Huadong Hospital Affiliated to Fudan University"
            },
            {
                "name": "Xiaobin Huang",
                "org": ""
            },
            {
                "name": "Hong Liu",
                "org": "Shanghai Jiao Tong University"
            }
        ],
        "venue": "Journal of Inorganic and Organometallic Polymers and Materials",
        "year": 2018
    },
    "RtCQSZZ2": {
        "id": "RtCQSZZ2",
        "title": "Hybrids based on transition metal phosphide (Mn2P, Co2P, Ni2P) nanoparticles and heteroatom-doped carbon nanotubes for efficient oxygen reduction reaction",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kuiyong chen",
                "org": "shanghai jiao tong university"
            },
            {
                "name": "xiaobin huang",
                "org": "shanghai jiao tong university"
            },
            {
                "name": "chaoying wan",
                "org": "international institute of minnesota"
            },
            {
                "name": "hong liu",
                "org": "shanghai jiao tong university"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "TbXIEss4": {
        "id": "TbXIEss4",
        "title": "Heteroatom-doped hollow carbon microspheres based on amphiphilic supramolecular vesicles and highly crosslinked polyphosphazene for high performance supercapacitor electrode materials",
        "abstract": "Abstract   Hybrid hollow polymeric microspheres (HPMSs) are synthesized by encapsulating the supramolecular vesicles with polyphosphazene through a rapid one-step polycondensation reaction. Subsequent carbonization treatments of the HPMSs lead to corresponding hollow carbon microspheres (HCMSs) with well-preserved geometry. The sizes of HPMSs and HCMSs are controlled by the vesicles, which is directly determined by the feeding ratio of the assembly units. Electrodes based on HCMSs showed a specific capacitance of 314.6\u00a0F/g at a current density of 0.2\u00a0A/g in 6\u00a0M KOH electrolyte, 180.0\u00a0F/g at a current density of 30\u00a0A/g, and high stability of 98.2% of capacity retention after 2000 cycles. Both the high surface area and high heteroatoms level of HCMSs contribute to the excellent capacitive performance. Meanwhile, the hollow carbon structure ensured the satisfactory capacitive performance by increasing utilization efficiency of the surface area as well as achieving short diffusion paths for electrolyte ions.",
        "keywords": "",
        "authors": [
            {
                "name": "Kuiyong Chen",
                "org": "School of Aeronautics and Astronautics, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China"
            },
            {
                "name": "Xiaobin Huang",
                "org": ""
            },
            {
                "name": "Chaoying Wan",
                "org": "International Institute for Nanocomposites Manufacturing (IINM), WMG, University of Warwick, Coventry CV4 7AL, UK"
            },
            {
                "name": "Hong Liu",
                "org": "School of Aeronautics and Astronautics, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, PR China"
            }
        ],
        "venue": "Electrochimica Acta",
        "year": 2016
    },
    "CE2WNHz7": {
        "id": "CE2WNHz7",
        "title": "Heteroatom-enhanced the formation of mesoporous carbon microspheres with high surface area as supercapacitor electrode materials",
        "abstract": "A novel supercapacitor electrode material based on heteroatom (N, O, P) doped mesoporous carbon microspheres (HMCMSs) was produced via a carbonization of highly cross-linked polyphosphazene microspheres (PMSs), with N, O, P acting as high efficient pore-forming agent. PMSs were synthesized through the polymerization reaction between melamine (MA) and hexachlorocyclotriphosphazene (HCCP). The high level of heteroatom atom of PMSs effectively afforde HMCMSs with high specific surface area (1854.1m2 /g), united mesopore structure (pore width ~3nm), as well as high supercapacitor performance. HMCMSs based electrodes exhibited highest specific capacitance of 274 F/g in 6 M KOH aqueous electrolyte at a current density of 0.2 A/g, and excellent cycling durability which had 98.4% capacitance retained even after 2000 cycles. These animative consequences of HMCMSs based electrodes show them great potential in developing highperformance supercapacitors for actual application.",
        "keywords": "",
        "authors": [
            {
                "name": "Z. Gao",
                "org": ""
            },
            {
                "name": "Xiaobin Huang",
                "org": ""
            },
            {
                "name": "Kuiyong Chen",
                "org": ""
            },
            {
                "name": "Chaoying Wan",
                "org": ""
            },
            {
                "name": "Hong Liu",
                "org": ""
            }
        ],
        "venue": "International Journal of Electrochemical Science",
        "year": 2017
    },
    "2fkNlwTh": {
        "id": "2fkNlwTh",
        "title": "Heteroatom-doped mesoporous carbon nanofibers based on highly cross-linked hybrid polymeric nanofibers: Facile synthesis and application in an electrochemical supercapacitor",
        "abstract": "",
        "keywords": [
            "nanostructures",
            "carbides",
            "polymers"
        ],
        "authors": [
            {
                "name": "kuiyong chen",
                "org": ""
            },
            {
                "name": "xiaobin huang",
                "org": ""
            },
            {
                "name": "chaoying wan",
                "org": ""
            },
            {
                "name": "hong liu",
                "org": ""
            }
        ],
        "venue": "Materials Chemistry and Physics",
        "year": 2015
    },
    "qcWX2agU": {
        "id": "qcWX2agU",
        "title": "Study on Fermentation Conditions and Degradation Ability of Degrading Fungi F31 of Chlorimuron-ethyl",
        "authors": [
            {
                "name": "REN Hong-lei"
            },
            {
                "name": "TAO Bo"
            },
            {
                "name": "LI Chun-xia"
            }
        ],
        "venue": "heilongjiang agricultural sciences",
        "keywords": [
            "degradation ability",
            "shake flask",
            "chlorimuron-ethyl",
            "degrading fungi F31"
        ],
        "year": 2013
    },
    "yKqhdQcY": {
        "id": "yKqhdQcY",
        "title": "Correlation Analysis of Dry-down and Grain Filling Rate in Maize",
        "abstract": "Nine inbred lines were used to mating crosses by Griffing's design \u2161,the correlation with yield were analyzed.The main results were as follows: it showed that grain filling rate,dry-down rate had high correlation with main agronomy traits.Grain filling rate had positive correlation with plant yield.The correlative coefficients was higher at stage \u2162 than that of at stage \u2161and stage\u2160.Grain filling rate was positive correlated with kernels on each ear,kernels per row,ear length,100-grain weight,volume weight,ear diameter and rows in each ear in sequence.Plant yield had positive direct path coefficient to kernels per ear,grain filling rate at stage III,days to silk,grain filling rate at stage I,100-grain weight,grain filling rate at stage II,durable time of grain filling in sequence.Kernel natural dry-down rate was positively correlative with ear stalk dry-down rate,husk dry-down rate and significant negative correlation with the ear traits.The biggest positive path coefficient to natural dry-down rate Husk dry down rate had,the biggest negative path coefficient was husk water content followed by 100-grain weight.",
        "keywords": [
            "dry-down rate",
            "filling rate",
            "maize",
            "path analysis",
            "correlation analysis"
        ],
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "SONG Xi-zhang",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "LI Guo-liang",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "HU Guang-hui",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "WANG Ming-quan",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "BEN Li",
                "org": "Sciences Information Bureau of Jixian County in Heilongjiang Province,Jixian "
            }
        ],
        "venue": "Heilongjiang Agricultural Sciences",
        "year": 2007
    },
    "mqblYbc7": {
        "id": "mqblYbc7",
        "title": "Preliminary Result of 'Cuoho Inducer No.1' Effect Haploid Induced Rate in Different Maize Germplasm",
        "abstract": "Studied Cuoho inducer 1 effect induced rate in different maize germplase,the resulted showed,the average haploid induction rate of different germplasm was 3.2%,there were significant differences between different groups.The Lancaster groups has the highest induced rate(4.6%) than the other groups at 5% significant level.The thermal conductivity of local germplasm had the lowest induced rate(1.8%) than the other groups at 1% significant level.Therefore, the optimal induction haploid groups were the Lancaster groups.All the five germplasms which induced haploid plant had higher ear natural fertility restoration,ear had average setting rate of 92.9%.Tassel low natural fertility restoration.There was a big difference in haploid tassel fertility restoration of different genotypes.Five germplasm groups had average shedding rate of 7.4%.Lvda Red Cob and Lancaster groups had the highest shedding rate than others.The agronomic characteristics including plant height,shedding period and ear characteristics of 13 Strain DH lines performed uniform,and 13 Strain DH lines had participated field test.",
        "keywords": [
            "induced rate",
            "maize",
            "haploid"
        ],
        "authors": [
            {
                "name": "LI Guo-liang",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "GONG Shi-chen",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "SONG Xi-zhang",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "HU Guang-hui",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            },
            {
                "name": "WANG Ming-quan",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang ,China"
            }
        ],
        "venue": "Rain Fed Crops",
        "year": 2008
    },
    "sJlkuW05": {
        "id": "sJlkuW05",
        "title": "Studies on Selection of Maize Inbred Lines and Its Hybrid Introduced in Tropical and Subtropical Germplasm",
        "abstract": "8 maize inbred lines which were introduced in tropical and subtropical germplasm were selected,and 2 test varieties were selected for each inbred line.The experiment was designed for comparative method.The results showed: After introduced Zhongdianerhuangma/EVT5,Mohuang 9 train and the hybrid of Mo17\u00d7Ji63 in Xi14,the yield was positive value to control,among that the introduction of Mohuang9 had comparison heterosis of 15.8% and 14.5%,respectively.After introduced 5-56,Fusu1 train and the hybrid of Mo17\u00d7Lv9 in Zi330,the yield was negative value to control.After introduced 5-56,fusu1 train and the hybrid of Mo17\u00d7Huangzao4 in B73,the yield was positive value to control.After introduced 5-50,4-6 train and the hybrid of Mo17\u00d7E28 in 5003,except the introduction of 5-50 train\u00d7E28 was positive value,the other 3 was negative value to control.",
        "keywords": [
            "heterosis",
            "inbred line",
            "hybrid",
            "tropical and subtropical maize germplasm"
        ],
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "GONG Shi-chen",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "SONG Xi-zhang",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "LI Guo-liang",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "HU Guang-hui",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "WANG Ming-quan",
                "org": "Maize Research Institute,Heilongjiang Academy of Agriculture Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "ZHANG Chang-sheng",
                "org": "The Xilian Agriculture Technology Service of Keshan Country,Keshan,Heilongjiang ,China"
            },
            {
                "name": "LI Xu-yuan",
                "org": "The Xilian Agriculture Technology Service of Keshan Country,Keshan,Heilongjiang ,China"
            }
        ],
        "venue": "Rain Fed Crops",
        "year": 2006
    },
    "RhLXT9B5": {
        "id": "RhLXT9B5",
        "title": "Study on North Early-matured Spring Maize Germplasm Enhancement and Utilization",
        "authors": [
            {
                "name": "SU Jun"
            },
            {
                "name": "LI Chun-xia"
            },
            {
                "name": "GONG Shi-chen"
            },
            {
                "name": "SONG Xi-zhang"
            },
            {
                "name": "YAN Shu-qin"
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Germplasm resources",
            "Inbred lines",
            "Hybrid",
            "Maize"
        ],
        "year": 2008
    },
    "wjUqM5wo": {
        "id": "wjUqM5wo",
        "title": "Combining Ability and Cluster Analysis on the Different types of Cold-resistant Maize Germplasm",
        "authors": [
            {
                "name": "HU Guang-hui",
                "org": " Institute of Maize Research, Heilongjiang Academy of Agricultural Sciences, Harbin ; Institute of Crop Science"
            },
            {
                "name": "WANG Tian-yu",
                "org": " Institute of Crop Science"
            },
            {
                "name": "SU Jun",
                "org": " Institute of Maize Research, Heilongjiang Academy of Agricultural Sciences, Harbin "
            },
            {
                "name": "LI Chun-xia",
                "org": " Institute of Maize Research, Heilongjiang Academy of Agricultural Sciences, Harbin "
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Combining ability",
            "Cold resistance",
            "Cluster analysis",
            "Maize",
            "Agronomy characters"
        ],
        "year": 2009
    },
    "Gd1WzCLQ": {
        "id": "Gd1WzCLQ",
        "title": "Research on Haploids Frequency of Different Germplasm and Generations in Maize by Cauho Inducer 1",
        "abstract": "Study on inducement haploids frequency of different germplasm and generations in maize by Cauho Inducer 1.The result showed that the average induction rate of Tang 4,Luda,Lancaster,Reid groups and thermal conductivity local germplasm five groups induced by Cauho Inducer 1 was 3.9%,but there were significant differences between different groups.Lancaster and Reid groups which haploid induced rate was 4.85% had the highest haploid induced rate than the other group,Inducement haploids frequency of Tang 4 and Luda group was 3.95%,thermal conductivity local germplasm group has 2.04% inducement haploids frequency.The rate of induction by Cauho Inducer 1 induced the same groups of different inter-generational survey results showed,the high generations S4,S5 had high haploid induced rate,but lower grains per plant.S1 had the lower induction rate,but had bigger corn ear,actually receive the largest number of haploid,so the best induction haploid generation is early generation S1.",
        "keywords": [
            "Hybrid inducement",
            "Haploid",
            "Maize"
        ],
        "authors": [
            {
                "name": "LI Guo-liang",
                "org": "Heilongjiang Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "SU Jun",
                "org": "Heilongjiang Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Heilongjiang Academy of Agricultural Sciences,Harbin ,China"
            }
        ],
        "venue": "Journal of Maize Sciences",
        "year": 2008
    },
    "ELfdJVzI": {
        "id": "ELfdJVzI",
        "title": "Genetic Analysis of Cold Tolerance Trait in Maize Germplasm Seedling Stage",
        "abstract": "The low temperature in early spring maize area is one of important natural disaster of Heilongjiang province and has become the important factor that elevated the corn yield level in this district.8 inbred lines that come from different cold tolerate and origins in this research and made by Griffing\u2161 design,gain the genetic regularity in emergence period and seedling period with low temperature adverse circumstances.Correlation analysis indicates that correlations exist between relative germination index,relative seedling ratio,relative plant dry weight,relative root dry weight each other.Relative seedling ratio has correlation with relative root total length.These traits can be used as seedling indexes for cool-tolerance identification.There are significant differences in the traits among GCA variance in different parents,SCA variance in relative seedling rate,relative seedling index,relative height of seedling,relative dry weight of seedling,relative dry weight of root,relative number of side root and relative length of the entire root.Additive gene effect is important in relative emergence ratio,relative germination index,relative plant dry weight,relative root dry weight,relative total root length,and narrow-sense heritability are generally lower than 50%,the sequence from high to low are relative germination index,relative seedling ratio,relative root dry weight,relative plant dry weight,relative root total length.These traits should be selected in higher generations.",
        "keywords": [
            "genetic analysis",
            "cool-tolerance trait",
            "maize",
            "seedling period"
        ],
        "authors": [
            {
                "name": "Hu Guanghui",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin ; Institute of Crop Science,Chinese Academy of Agricultural Sciences,Beijing "
            },
            {
                "name": "Wang Tianyu",
                "org": " Institute of Crop Science,Chinese Academy of Agricultural Sciences,Beijing "
            },
            {
                "name": "Su Jun",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Li Chunxia",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Gong Shichen",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Yan Shuqin",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Li Guoliang",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Wang Mingquan",
                "org": " Institute of Maize Research,Heilongjiang Academy of Agricultural Sciences,Harbin "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2009
    },
    "C4Ho09K8": {
        "id": "C4Ho09K8",
        "title": "Genetic Diversity Analysis of Portion Maize Inbred Lines from North China",
        "authors": [
            {
                "name": "WANG Ming-quan",
                "org": " Maize Research Institute, Heilongjing Academy of Agricultural Sciences, Harbin "
            },
            {
                "name": "SU Jun",
                "org": " Maize Research Institute, Heilongjing Academy of Agricultural Sciences, Harbin "
            },
            {
                "name": "LI Chun-xia",
                "org": " Maize Research Institute, Heilongjing Academy of Agricultural Sciences, Harbin "
            },
            {
                "name": "GONG Shi-chen",
                "org": " Maize Research Institute, Heilongjing Academy of Agricultural Sciences, Harbin "
            },
            {
                "name": "ZHANG Rui-ying",
                "org": " Cereal Quality Research Center, Heilongjiang Academy of Agricultural Sciences, Harbin , China"
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Maize inbred lines",
            "Genetic diversity",
            "SSR marker"
        ],
        "year": 2010
    },
    "T7iKiSzj": {
        "id": "T7iKiSzj",
        "title": "Combining Ability of Grain Filling Rate in Maize",
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Sciences, Harbin , China"
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Sciences, Harbin , China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Sciences, Harbin , China"
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Combining ability",
            "Filling rate",
            "Grain",
            "Maize"
        ],
        "year": 2007
    },
    "iRhW8el5": {
        "id": "iRhW8el5",
        "title": "Combining Ability of Kernel Dry-down in Maize",
        "abstract": "Nine inbred lines were used to mating crosses by Griffing's design 2,the combining ability of dry-down rate,he main results are dicussed in the following:The combining ability of dry down rate: dry down rate of kernel,ear cob and husk were measured.The combining ability values of inbred line HR705,HR304 and HR112 were lower and negative in all of these characters.The combining ability of inbred line 2,HR11,Huangzaosi and HR106 were higher and positive in all of these characters.The combining ability effects of inbred line Dan340 and K10 were negative in some characters and positive in the others.The special combining ability had more differences.in 9 inbreds.The physiological and natural dry down rate were highest in the hybrid HR112\u00d7HR106.The dry down rate of husk was highest in the hybrid Huangzaosi\u00d7HR106.",
        "keywords": [
            "maize",
            "combining ability",
            "inbred line",
            "dry down rate"
        ],
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "GONG Shi-Chen",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "SONG Xi-zhang",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "LI Guo-liang",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "HU Guang-hui",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "WANG Ming-quan",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "BEN Li",
                "org": "Jixian Scientech Information Bureau,Jixian,Heilongjiang ,China"
            }
        ],
        "venue": "Rain Fed Crops",
        "year": 2007
    },
    "VJOyj0T7": {
        "id": "VJOyj0T7",
        "title": "The Genetic Diversity of Parents Inbred Lines from Parts of Released Corn Hybrids in Heilongjiang Province",
        "abstract": "The climate condition of Heilongjiang province is different from others.The relationship of maize family tree is too miscellaneous to identify easily.The problem of gerplasm deficiency is becoming more and more serious.The genetic diversity of 18 parents inbred lines from parts of new released varieties in Heilongjiang province and 5 standard tester were analyzed by SSR marker technology,43 pairs of primers were selected from 79 tested core SSR primer,174 polymorphic loci were detected and 2 to 8 alleles for each primer,4.35 alleles for each loci in average and mean PIC value was 0.586.4 genetic groups were divided for the 23 inbred lines by UPGMA clustering analyses.The result showed that the parental lines of released variety in Heilongjiang were centralized among Lancaster and Reid heterosis groups.",
        "keywords": [
            "Heilongjiang province",
            "genetic diversity",
            "maize inbred lines",
            "SSR marker"
        ],
        "authors": [
            {
                "name": "Wang Mingquan",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Su Jun",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Li Chunxia",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Gong Shichen",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Zhang Ruiying",
                "org": "Cereal Quality Research Center of Heilongjiang Academy of Agricultural Sciences"
            },
            {
                "name": "Song Xizhang",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Yan Shuqin",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Li Guoliang",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Hu Guanghui",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Guan Haitao",
                "org": "Cereal Quality Research Center of Heilongjiang Academy of Agricultural Sciences"
            },
            {
                "name": "Wang Weiwei",
                "org": "Cereal Quality Research Center of Heilongjiang Academy of Agricultural Sciences"
            },
            {
                "name": "Cao Shiliang",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "Cao Juanhua",
                "org": "Junchuan Farm of Heilongjiang Province,Luobei Heilongjiang "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2009
    },
    "AihYPb3s": {
        "id": "AihYPb3s",
        "title": "Study on Utilization of Tropic and Sub-tropic Maize Germplasm in Northern Early-Mature Spring Maize Breeding",
        "authors": [
            {
                "name": "SU Jun",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences.Harbin ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences.Harbin ,China"
            },
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Institute,Heilongjiang Academy of Agricultural Sciences.Harbin ,China"
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Comparison heterosis",
            "Hybrids",
            "Maize germplasm",
            "Inbred line"
        ],
        "year": 2010
    },
    "IaAhdSho": {
        "id": "IaAhdSho",
        "title": "Evaluation on Selection of Inbred Lines Introduced with Suwan1 Maize Germplasm",
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Sciences,Harbin ,China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Sciences,Harbin ,China"
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Improved inbred lines",
            "Contrast heterosis",
            "Suwan1 germplasm",
            "Improved crossbreed"
        ],
        "year": 2007
    },
    "jhxGxq9m": {
        "id": "jhxGxq9m",
        "title": "Analysis and Estimate on Combining Ability of Inbred lines from Three Populations",
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Science, Harbin , China"
            },
            {
                "name": "SU Jun",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Science, Harbin , China"
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Department of Heilongjiang Academy of Agricultural Science, Harbin , China"
            }
        ],
        "venue": "journal of maize sciences",
        "keywords": [
            "Heterosis",
            "Combining ability",
            "Inbred line"
        ],
        "year": 2007
    },
    "YjLr4AiC": {
        "id": "YjLr4AiC",
        "title": "Studies on the Heterosis of Introducing Self-bred from Tropical and Subtropical Corns for the Variety Development by Selection",
        "abstract": "8 self-breds from tropical and subtropical corns introduced for the variety development were selected,and 2 test varieties were selected for each self-bred.The experiment was designed for contras.The results showed: After the introduction of Suwanl and 5-56 strain,the yield of Diangu11A(a1\u00d7 red corn and a2\u00d7red corn) were 18.9% and 9.4% higher than control respectively.The comparison heterosis in yield for a1\u00d7Zaodahuang and a2\u00d7Zaodahuang were both negative values.After the introduction of Suwanl,EVT5 strain to red corn,b1\u00d7Diangu11A and b2\u00d7Diangu11A had the comparison heterosis of 14.0% and 9.4% respectively.b1\u00d7C500 and b2\u00d7C500 had the comparison heterosis of 4.8% and 12.5%,respectively.After the introduction of Suwan1,Mohuang 9 strain to Chang3,c1\u00d7Hai014 and c2\u00d7Hai014 had the comparison heterosis of 15.8% and 9.4%,respectively.c1\u00d7Longkang11 and c2\u00d7Longkang11 had the heterosis of(-4.0%) and 6.6%,respectively.After the introduction of Suwan1,5-50 strain to Mo17,d1\u00d7B73 and d2\u00d7B73 had the comparison heterosis of 2.0% and-4.6%;d1\u00d7444 and d2\u00d7444 had the comparison heterosis of 3.8% and 12.2%,respectively.",
        "keywords": [
            "comparison heterosis",
            "maize germplasm",
            "hybrid"
        ],
        "authors": [
            {
                "name": "YAN Shu-qin",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "SU Jun",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "LI Chun-xia",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "GONG Shi-chen",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "SONG Xi-zhang",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "LI Guo-liang",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "HU Guang-hui",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            },
            {
                "name": "WANG Ming-quan",
                "org": "Corn Research Institute,Heilongjiang Academy of Agricultural Sciences,Harbin "
            }
        ],
        "venue": "Heilongjiang Agricultural Sciences",
        "year": 2006
    },
    "9XjxFpW3": {
        "id": "9XjxFpW3",
        "title": "Analysis of the Combining Ability of Maize Grain Filling and Dehydration Rate",
        "abstract": "For the purpose of exploring the differences between inbred lines,realizing high yield and super quality selection through screening filling and dehydration rate,taking nine kinds of inbred lines as materials,according to Griffing's Diallel-Cross for Method II,the combining ability of eight traits was studied.The results showed that the combining ability of grain filling rate of Huangzao4,Dan 340and HR112were higher,followed by Mo17,HR11,the lowest were HR705and HR 106.The grain filling rate of HR 304was faster and then slower,while K 10was the opposite.The combining ability of dehydration rate of Mo17,HR11,Huangzao4and HR106was higher,followed by HR 705,HR 304and HR 112.GCA positive effect values of Mo17,HR 11,Huangzao4,and Dan 340were more than negative values,which was worth researching and utilizing.",
        "keywords": [
            "dehydration rate",
            "maize",
            "grain filling rate",
            "combining ability"
        ],
        "authors": [
            {
                "name": "SU Jun",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "LI Chun-xia",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "GONG Shi-chen",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "YAN Shu-qin",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "LI Guo-liang",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "HU Guang-hui",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            },
            {
                "name": "WANG Ming-quan",
                "org": "Maize Research Institute of Heilongjiang Academy of Agricultural Sciences,Harbin,Heilongjiang "
            }
        ],
        "venue": "Heilongjiang Agricultural Sciences",
        "year": 2013
    },
    "UnP9cs5K": {
        "authors": [
            {
                "name": "Zhi-Gang Zhang",
                "org": "Institute of Photoelectric Technology and Solar Energy"
            },
            {
                "name": "Hong-Cai Wu",
                "org": "Institute of Photoelectric Technology and Solar Energy"
            },
            {
                "name": "Wen-Hui Yi",
                "org": "Institute of Photoelectric Technology and Solar Energy"
            }
        ],
        "title": "Third-order nonlinear optical properties of two novel poly (3-butyrylpyrrole methines)",
        "abstract": "Two novel soluble poly (pyrrole methines), poly[(3-butyrylpyrrole-2,5-diyl) p-nitrobenzylidene](PBPNBE) and poly[(3-butyrylpyrrole-2,5-diyl) (3-hydroxy-4-methoxy)benzylidene] (PBPHMBE), were synthesized firstly by condensation of 3-butyrylpyrrole with p-nitrobenzaldehyde and vanillin, respectively. The chemical structures of monomer, PBPNBE and PBPHMBE were proved by FT-IR, ",
        "keywords": [
            "Degenerate four-wave mixing",
            "Poly [(3-butyrylpyrrole-2,5-diyl) (3-hydroxy-4-methoxy)benzylidene]",
            "Poly [(3-butyrylpyrrole-2,5-diyl) p-nitrobenzylidene]",
            "Synthesis and characterization optical forbidden band gap",
            "Third-order nonlinear susceptibility"
        ],
        "venue": "Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering",
        "year": 2005,
        "id": "UnP9cs5K"
    },
    "9EcRGG4f": {
        "authors": [
            {
                "name": "Jialiang Li",
                "org": "Department of Urban and Environment"
            },
            {
                "name": "Lijuan Wu",
                "org": "College of Earth Science and Environmental Engineering"
            },
            {
                "name": "Changqing Shan",
                "org": "Department of Urban and Environment"
            },
            {
                "name": "Xue Wang",
                "org": "Department of Urban and Environment"
            }
        ],
        "title": "Decoloration of dyeing wastewater by Mg2+ salts and slag",
        "abstract": "Under the conditions of different pH, temperatures, Mg",
        "keywords": [
            "Dyeing wastewater",
            "Mg2+salt",
            "Slag",
            "Synergistic decoloration"
        ],
        "venue": "Chinese Journal of Environmental Engineering",
        "year": 2014,
        "id": "9EcRGG4f"
    },
    "pSceVT5E": {
        "authors": [
            {
                "name": "Lining Zhang",
                "org": "Research Center of Micro- and Nano-Device and Technology"
            },
            {
                "name": "Yan Guan",
                "org": "TSRC"
            },
            {
                "name": "Wang Zhou",
                "org": "TSRC"
            },
            {
                "name": "Lin Chen",
                "org": "TSRC"
            },
            {
                "name": "Yiwen Xu",
                "org": "TSRC"
            },
            {
                "name": "Jin He",
                "org": "Research Center of Micro- and Nano-Device and Technology"
            }
        ],
        "title": "A carrier-based analytic drain current model incorporating velocity saturation for undoped surrounding-gate MOSFETs",
        "abstract": "A carrier-based analytic drain current model including the velocity saturation effect for the undoped surrounding-gate (SRG) MOSFETs is developed in this paper. Based on the previously ideal carrier-based drain current model, the Caughey-Thomas mobility model with an exponent factor n = 2 is applied and integrated into the analytic drain current model development. The validity of the presented model is confirmed by comparisons with three-dimensional (3D) TCAD device simulations for good agreements between the model prediction and numerical simulation on transfer/output characteristics and trans/output- conductance of the SRG MOSFETs are obtained in the whole operation regions from subthreshold to strong inversion and from linear to saturation regions. The symmetry property of the developed drain current model is guaranteed by the exponent factor n = 2 in the Caughey-Thomas model and also further tested, promoting the analog circuit design function of the proposed model. \u00a9 2009 IOP Publishing Ltd.",
        "keywords": [
            ""
        ],
        "venue": "Semiconductor Science and Technology",
        "year": 2009,
        "id": "pSceVT5E"
    },
    "GNjmD8WJ": {
        "id": "GNjmD8WJ",
        "title": "The Preparation of Chlorophyll Iron Salt",
        "abstract": "The sodium iron chlorophyllin by the chlorophyl form Sonchus oleraceus L was obtained through the following successive steps: saponificatioan,acidification,replacement of sodium by iron,and neutalization.Its quality was evaluated by UV-spectrophotometer.Single factor experiment and response surface method in optimization of process test conditions: Firstly,chlorophyl is saponifieated for 90min at 59\u2103 in the system with pH\u224812;Secondly,the saponificated production is acidificated for 60min at 65\u2103 in the system with pH\u22482~3;And afterword replaces sodium with 42mL 10%FeSO_4 for 97min.Finally,the sodium iron chlorophyllin is obtained by neutralizing at pH\u224812 with 10%NaOH-ethanol.",
        "keywords": [
            "sodium iron chlorophyllin",
            "Sonchus oleraceus L",
            "chlorophyl",
            "tenchology"
        ],
        "authors": [
            {
                "name": "Li Xiang",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and technology, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,ShaanXi,China"
            },
            {
                "name": "Wen Xing",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and technology, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,ShaanXi,China"
            },
            {
                "name": "Fang Yuan",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and technology, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,ShaanXi,China"
            },
            {
                "name": "Li Jin",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and technology, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,ShaanXi,China"
            },
            {
                "name": "Wu Hao",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and technology, Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,ShaanXi,China"
            }
        ],
        "venue": "Food and Fermentation Industries",
        "year": 2012
    },
    "C2OZEyHt": {
        "id": "C2OZEyHt",
        "title": "Optimization of enzyme-assisted extraction of tea saponin by orthogonal design",
        "abstract": "The cellulase-assisted extraction of tea saponin from tea seed meal was studied.The extraction was optimized by single factor experiment and orthogonal design with the yield of tea saponin as an indicator.The optimal extraction parameters were as follows: pH 5.1,enzymolysis temperature 47 \u2103,enzymolysis time 130 min,dosage of cellulase 1.125 mg/mL.Under the optimal conditions,the yield of tea saponin achieved 20.23%.The SEM of the defatted tea seed meal before and after enzymolysis showed that the surface of the tea seed meal after enzymolysis turned to be rough and adhered to each other,which demonstrated that the cell wall of tea seed was destroyed by cellulase.",
        "keywords": [
            "orthogonal design",
            "extraction",
            "tea saponin",
            "cellulase"
        ],
        "authors": [
            {
                "name": "LI Xiang",
                "org": "College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology, Xi'an ,China"
            },
            {
                "name": "LI Jin",
                "org": "College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology, Xi'an ,China"
            },
            {
                "name": "CAO Wanxin",
                "org": "Xi'an Oils & Fats Research & Design Institute,State Administration of Grain Reserve of P.R.C.,Xi'an ,China"
            },
            {
                "name": "WEN Xing",
                "org": "College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology, Xi'an ,China"
            },
            {
                "name": "WU Hao",
                "org": "College of Chemistry and Chemical Engineering,Shaanxi University of Science and Technology, Xi'an ,China"
            },
            {
                "name": "SHI Yundong",
                "org": "College of Resource and Environment, Yuxi Normal University,Yuxi ,Yunnan,China"
            }
        ],
        "venue": "China Oils and Fats",
        "year": 2012
    },
    "BCdo6KKU": {
        "id": "BCdo6KKU",
        "title": "Study on the optimization research of potato starch oxidation",
        "abstract": "With Fenton reagent as oxidant to oxidize potato starch,the effect of pH,oxidized temperature,oxidized time,30% H2O2dosage,FeSO4dosage on carboxyl content in oxidized starch were studied.Based on single factors experiments,the oxidation technology of potato starch was optimized through Box-Behnken,built and analyzed a mathematical model of the relationship between factors and content.Results showed that with the condition of 30% H2O2dosage of 25mL,pH 10 and oxidation temperature of 50\u2103,oxidized starch had 1.4590% carboxyl content,which was close to theoretical value of 1.4699%.It explained that regression model could precast carboxyl content of oxidized starch better.There were some holes on the surface of starch granule after oxidation through SEM.And carboxyl characteristic absorption peak was proved to exist by IR.",
        "keywords": [
            "carboxyl content",
            "potato starch",
            "response surface methodology",
            "Fenton reagent"
        ],
        "authors": [
            {
                "name": "LI Xiang",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and Technology,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,China"
            },
            {
                "name": "FANG Yuan",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and Technology,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,China"
            },
            {
                "name": "WEN Xing",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and Technology,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,China"
            },
            {
                "name": "LI Jin",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and Technology,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,China"
            },
            {
                "name": "WU Hao",
                "org": "College of Chemistry and Chemical Engineering,ShaanXi University of Science and Technology,Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry,Ministry of Education,Xi'an ,China"
            }
        ],
        "venue": "Science and Technology of Food Industry",
        "year": 2012
    },
    "egz9vuTi": {
        "id": "egz9vuTi",
        "title": "A rhodamine-based fluorescent probe for colorimetric and fluorescence lighting-up determination of toxic thiophenols in environmental water and living cells.",
        "abstract": "Thiophenols are a class of highly toxic environmental pollutant, hence it is very necessary to monitor thiophenols in environment and living cells with an efficient and reliable method. Herein, a novel fluorescent probe for thiophenols has been developed, which exhibited a colorimetric and fluorescence turn-on dual response towards thiophenols with good selectivity and fast response. The sensing mechanism for thiophenols was attributed to nucleophilic substitution reaction, which was confirmed by HPLC. The probe exhibited good recovery (from 90% to 107%) and low limit of detection for thiophenols (37nM) in industrial wastewater. Moreover, the probe has been successfully employed to visualize thiophenol in living cells. Therefore, the fluorescent probe has good capability for monitoring thiophenols in environmental samples and biological systems.",
        "keywords": [
            "Fluorescent probe",
            "Imaging",
            "Lighting-up",
            "Rhodamine",
            "Thiophenol",
            "Wastewater"
        ],
        "authors": [
            {
                "name": "Juanjuan Wu",
                "org": "Institute of Veterinary Drug/Jiangxi Provincial Key Laboratory for Animal Health, Jiangxi Agricultural University, Nanchang 330045, PR China; Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China."
            },
            {
                "name": "Zhuo Ye",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China."
            },
            {
                "name": "Feng Wu",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China."
            },
            {
                "name": "Hongying Wang",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China."
            },
            {
                "name": "Lintao Zeng",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address: zlt1981@126.com."
            },
            {
                "name": "Guang-Ming Bao",
                "org": "Institute of Veterinary Drug/Jiangxi Provincial Key Laboratory for Animal Health, Jiangxi Agricultural University, Nanchang 330045, PR China. Electronic address: bycb2005@gmail.com."
            }
        ],
        "venue": "Talanta",
        "year": 2018
    },
    "BdysNdSP": {
        "id": "BdysNdSP",
        "title": "A fluorescence-enhanced probe for rapid detection of formaldehyde and its application for cell imaging",
        "abstract": "A simple anthracene carboxyimide-based fluorescent probe has been readily developed for the detection of toxic formaldehyde (FA). The probe displays a remarkable fluorescence turn-on response towards FA based on the aldimine condensation reaction, which was confirmed by the HR-MS spectrum. The probe can quantitatively determine the level of FA with high selectivity and fast response (within 3 min). Furthermore, cell staining experiments indicate that the probe was cell membrane permeable and could be used for imaging FA in living cells with good performance. Therefore, this probe has promising applications for the detection of FA in living cells.",
        "keywords": "",
        "authors": [
            {
                "name": "Feng Wu",
                "org": "Clinical Medical College of Tianjin Medical University,Tianjin 300270,P. R. China"
            },
            {
                "name": "Feng Wu",
                "org": "Clinical Medical College of Tianjin Medical University,Tianjin 300270,P. R. China"
            },
            {
                "name": "Yue Zhang",
                "org": "School of Chemistry and Chemical Engineering, Tianjin University of Technology,Tianjin 300384,P. R. China"
            },
            {
                "name": "Lei Huang",
                "org": "School of Chemistry and Chemical Engineering, Tianjin University of Technology,Tianjin 300384,P. R. China"
            },
            {
                "name": "Dan Xu",
                "org": "Clinical Medical College of Tianjin Medical University,Tianjin 300270,P. R. China"
            },
            {
                "name": "Hongying Wang",
                "org": "School of Chemistry and Chemical Engineering, Tianjin University of Technology,Tianjin 300384,P. R. China"
            }
        ],
        "venue": "Analytical Methods",
        "year": 2017
    },
    "ZQdq7Rmq": {
        "id": "ZQdq7Rmq",
        "title": "Lysosome-targetable polythiophene nanoparticles for two-photon excitation photodynamic therapy and deep tissue imaging",
        "abstract": "Two-photon excitation (TPE) photodynamic therapy (PDT) has attracted great interest due to its distinctive properties, e.g., good penetration ability of biological tissues and less damage to healthy tissues. However, the conventional photosensitizers (PSs) for PDT have poor subcellular location capability and low two-photon absorption (TPA) cross section in the phototherapeutic window. Herein, we report a fascinating multi-functional TPE PS, polythiophene nanoparticles (PT NPs), for simultaneous lysosome-targetable fluorescence imaging and PDT. PT NPs show bright yellow fluorescence, good water solubility as well as excellent photo- and pH-stability. Moreover, PT NPs exhibit high singlet oxygen generation quantum yield (\u223c42%) and large TPA cross section (\u223c3420 GM). A fluorescence imaging penetration depth of 1800 \u03bcm could be reached in the tissue phantom under the TPE mode. Due to these outstanding merits and their unique clathrin- and caveola-independent intracellular uptake pathway, PT NPs have great potential for application in TPE fluorescence imaging and photodynamic therapy.",
        "keywords": "",
        "authors": [
            {
                "name": "Shaojing Zhao",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology,Tianjin,China"
            },
            {
                "name": "Shaojing Zhao",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology,Tianjin,China"
            },
            {
                "name": "Guangle Niu",
                "org": "Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS),Beijing,China"
            },
            {
                "name": "Guangle Niu",
                "org": "Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS),Beijing,China"
            },
            {
                "name": "Feng Wu",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology,Tianjin,China"
            },
            {
                "name": "L. Yan",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology,Tianjin,China"
            },
            {
                "name": "Hongyan Zhang",
                "org": "Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS),Beijing,China"
            },
            {
                "name": "J. X. Zhao",
                "org": "Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry (TIPC), Chinese Academy of Sciences (CAS),Beijing,China"
            },
            {
                "name": "Lintao Zeng",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology,Tianjin,China"
            },
            {
                "name": "Minhuan Lan",
                "org": "Center of Super-Diamond and Advanced Films (COSDAF) & Department of Physics and Materials Science, City University of Hong Kong,,China"
            }
        ],
        "venue": "Journal of Materials Chemistry B",
        "year": 2017
    },
    "MhtYUkyz": {
        "id": "MhtYUkyz",
        "title": "A new fluorescent chemodosimeter for ultra-sensitive determination of toxic thiophenols in environmental water samples and cancer cells",
        "abstract": "Abstract   A novel fluorescent chemodosimeter for thiophenols has been readily developed from a red emitting  Indole-BODIPY . The chemodosimeter displays a significant fluorescence turn-on response towards thiophenols based on nucleophilic substitution reaction. A linear relationship was obtained between the fluorescence intensity and the concentrations of thiophenols ranging from 0 to 1.8\u00a0\u03bcM. The chemodosimeter can determine thiophenols (4-fluorothiophenol, 4-methoxybenzenethiol,  p -toluenethiol) with high selectivity, fast response (within 8\u00a0min) and extremely low limit of detection (9.8\u00a0nM). The chemodosimeter was successfully used to determine the level of thiophenol (PhSH) in industrial wastewater and Bohai Sea water with good recoveries. Furthermore, the chemodosimeter was employed to image thiophenols in cancer cells with good performance and low cytotoxicity. Therefore, this chemodosimeter has great potential application in environment.",
        "keywords": "",
        "authors": [
            {
                "name": "Feng Wu",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China"
            },
            {
                "name": "Hongying Wang",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China"
            },
            {
                "name": "Junchao Xu",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China"
            },
            {
                "name": "Houqun Yuan",
                "org": "School of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, PR China"
            },
            {
                "name": "Lintao Zeng",
                "org": "Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China"
            },
            {
                "name": "Guang-Ming Bao",
                "org": "School of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, PR China"
            }
        ],
        "venue": "Sensors and Actuators B-chemical",
        "year": 2018
    },
    "O440tpOE": {
        "authors": [
            {
                "name": "Bin Zhao",
                "org": "College of Electrical and Electronic Engineering"
            },
            {
                "name": "Wen You",
                "org": "College of Electrical and Electronic Engineering"
            },
            {
                "name": "Jing Jin",
                "org": "College of Electrical and Electronic Engineering"
            }
        ],
        "title": "Study on tiltable system of AOD furnace on the feed forward vector control basis",
        "abstract": "For sake to ensure accuracy requirements of tilting of time and position for the tilting system of AOD furnace, it aims at characteristics of low-speed, overload, frequent startup and brake, and strong impacting Loads for the AOD furnace. In this paper, the scheme of rotary speed double-closed loop control based on vector control was put forward, with a feed-forward position. Location and rotary speed regulators was used PID to achieve, in the scheme, at the same time, a mathematical modeling was carried out for AOD location controller, on that basis, and a software simulation was conducted for the control system. The results show that, within 8 s regulating time, location steady-state error was 0, and the system steady-state and transient condition index have fully met the technical requirements. \u00a9 2010 IEEE.",
        "keywords": [
            "Feed forward control",
            "Position controller",
            "Vector control"
        ],
        "venue": "2010 International Conference on Computer, Mechatronics, Control and Electronic Engineering, CMCE 2010",
        "year": 2010,
        "id": "O440tpOE"
    },
    "j67a9QBC": {
        "authors": [
            {
                "name": "M. Wu",
                "org": ""
            },
            {
                "name": "L. Yang",
                "org": ""
            },
            {
                "name": "S. Liu",
                "org": ""
            },
            {
                "name": "H. Li",
                "org": ""
            },
            {
                "name": "N. Hui",
                "org": ""
            },
            {
                "name": "F. Wang",
                "org": ""
            },
            {
                "name": "H. Liu",
                "org": ""
            }
        ],
        "title": "Differentiation potential of human embryonic mesenchymal stem cells for skin-related tissue",
        "abstract": "Background: Mesenchymal stem cells (MSC) have the capacity to differentiate into cells of connective tissue lineages, including bone, fat, cartilage and muscle, but the differentiation of embryonic MSC into epidermal cells by mesenchymal-epithelial transition has not been confirmed. Objectives: To determine the biological characteristics of human embryonic MSC (hMSC) and their potential for differentiation into epithelial cells. Methods: hMSC were derived from 4-7-week-old embryos; they were localized and isolated, then primary culture was done. The biological characteristics of hMSC were detected by immunohistochemical methods and flow cytometry. Their differentiation potential was determined by coculture with conditioning medium and in vivo injection. Results: hMSC express the relative specific antigens of MSC, such as SH2, \u03b1-smooth actin, CD29, CD44, CD90 and S100. After stimulation and in vivo transplantation, hMSC possess the potential to differentiate into epidermal cells with the production of keratin 19 and E-cadherin. Conclusions: hMSC derived from the early human embryo have the ability to transform into epidermal cells in vivo and in vitro. \u00a9 2006 British Association of Dermatologists.",
        "keywords": [
            "Differentiation",
            "Epidermal cell",
            "Human embryonic mesenchymal stem cells"
        ],
        "venue": "British Journal of Dermatology",
        "year": 2006,
        "id": "j67a9QBC"
    },
    "1dJcE7ZV": {
        "id": "1dJcE7ZV",
        "title": "Analysis on the Modeling Method of Conditional Recovery Rate:Based on the Maximum Entropy Principle",
        "authors": [
            {
                "name": "LIN Jie",
                "org": "Department,School of Economics,Xiamen University,Xiamen ,China"
            }
        ],
        "venue": "statistics & information forum",
        "keywords": [
            "maximum entropy principle",
            "loss given default",
            "conditional recovery rate"
        ],
        "year": 2008
    },
    "Kj5ZUFXv": {
        "id": "Kj5ZUFXv",
        "title": "Achromatic flat focusing lens based on dispersion engineering of spoof surface plasmon polaritons",
        "abstract": "In this letter, we first analyze the dispersion relation for achromatic focusing and obtain the achromatic focusing conditions for discretized unit cells of flat lenses. Then, we propose to engineer the dispersion of spoof surface plasmon polaritons (SSPPs) to satisfy the achromatic focusing conditions. Metallic blades structures are utilized to achieve the linear dispersion response by tailoring the weak dispersion region of SSPPs. A broadband achromatic flat focusing lens (AFFL) is implemented with delicate combinations of the blade structures. A prototype was designed, fabricated, and measured. Both the simulated and experimental results demonstrate that the proposed AFFL can achieve achromatic focusing from 7.5 to 9.0\u2009GHz under the normal incidence.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Yang",
                "org": "College of Science, Air Force Engineering University, Xi'an 710051, Shaanxi, China"
            },
            {
                "name": "Jiafu Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an 710051, Shaanxi, China"
            },
            {
                "name": "Mingde Feng",
                "org": "College of Science, Air Force Engineering University, Xi'an 710051, Shaanxi, China"
            },
            {
                "name": "Yongfeng Li",
                "org": "College of Science, Air Force Engineering University, Xi'an 710051, Shaanxi, China"
            },
            {
                "name": "Xinhua Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an 710051, Shaanxi, China"
            },
            {
                "name": "Xiaoyang Zhou",
                "org": "State Key Laboratory of Millimeter Waves, Southeast University, Nanjing 210096, Jiangsu, China"
            },
            {
                "name": "Tie Jun Cui",
                "org": "State Key Laboratory of Millimeter Waves, Southeast University, Nanjing 210096, Jiangsu, China"
            },
            {
                "name": "Shaobo Qu",
                "org": "College of Science, Air Force Engineering University, Xi'an 710051, Shaanxi, China"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2017
    },
    "eAvx482u": {
        "id": "eAvx482u",
        "title": "Wideband planar retro-reflective metasurfaces for backscattering enhancement under oblique incidence",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuxiang Jia",
                "org": ""
            },
            {
                "name": "Jiafu Wang",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Yongfeng Li",
                "org": ""
            },
            {
                "name": "Yongqiang Pang",
                "org": ""
            },
            {
                "name": "Ya Fan",
                "org": ""
            },
            {
                "name": "Sai Sui",
                "org": ""
            },
            {
                "name": "Shaobo Qu",
                "org": ""
            }
        ],
        "venue": "Journal of Physics D",
        "year": 2018
    },
    "PLmJ7lqc": {
        "id": "PLmJ7lqc",
        "title": "Metamaterial anti-reflection lining for enhancing transmission of high-permittivity plate",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongzhi Li",
                "org": ""
            },
            {
                "name": "Jiafu Wang",
                "org": ""
            },
            {
                "name": "Jie Yang",
                "org": ""
            },
            {
                "name": "Jun Wang",
                "org": ""
            },
            {
                "name": "Mingde Feng",
                "org": ""
            },
            {
                "name": "Yongfeng Li",
                "org": ""
            },
            {
                "name": "Jieqiu Zhang",
                "org": ""
            },
            {
                "name": "Shaobo Qu",
                "org": ""
            }
        ],
        "venue": "Journal of Physics D",
        "year": 2018
    },
    "lQX5prum": {
        "id": "lQX5prum",
        "title": "Broadband planar achromatic anomalous reflector based on dispersion engineering of spoof surface plasmon polariton",
        "abstract": "Planar reflectors are generally composed of non-uniform inclusions positioned on conducting sheet. Restricted by strong dispersion of the inclusions, the reflection of planar reflectors is usually chromatic. In this letter, we first obtain the dispersion relation for planar achromatic anomalous reflector (PAAR). Then, we propose to realize the dispersion relation based on dispersion engineering of spoof surface plasmon polariton (SSPP). Metallic blades structure is proposed to achieve the linear dispersion response by tailoring the weak dispersion region of SSPP. 6 metallic blade structures are designed to compose the super cell of the PAAR. A prototype was fabricated and measured. Both the simulation and experiment results show that the PAAR can achieve an achromatic reflected angle of 49.3\u00b0 in 10.7\u201311.7\u2009GHz under normal incidence.",
        "keywords": "",
        "authors": [
            {
                "name": "Jie Yang",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            },
            {
                "name": "Jiafu Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            },
            {
                "name": "Yongfeng Li",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            },
            {
                "name": "Zhuoluo Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            },
            {
                "name": "Hongya Chen",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            },
            {
                "name": "Xinhua Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            },
            {
                "name": "Shaobo Qu",
                "org": "College of Science, Air Force Engineering University, Xi'an, 710051 Shaanxi, China"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2016
    },
    "RXwBG7Wt": {
        "id": "RXwBG7Wt",
        "title": "Retro-reflective metasurfaces for backscattering enhancement under oblique incidence",
        "abstract": "In this letter, we propose the design of retro-reflective metasurfaces for enhancing backscattering under oblique incidence. Through reflective phase profile design along the surface, an equivalent wave-vector can be generated, with double magnitude but opposite direction to the parallel component k|| of the wave-vector k0 of incident waves. Due to this artificial parallel wave-vector, the main lobe of reflective waves can be reoriented backwards. As an example, we demonstrate an X-band retro-reflective metasurface that can operate effectively under oblique incidence \u03b8=20\u00b0. A modified metallic square loop structure is used to achieve the required phase profile under oblique incidence. Through the phase gradient design, the metasurface can reflect incident waves backwards at 9.8GHz under transverse electric (TE) polarizations. A prototype was fabricated and measured. Both the simulation and experiment results verify the good retro-reflection performance of the metasurface.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuxiang Jia",
                "org": "College of Science, Air Force Engineering University, Xi\u2019an 710051, Shaanxi, China"
            },
            {
                "name": "Jiafu Wang",
                "org": ""
            },
            {
                "name": "Yongfeng Li",
                "org": "College of Science, Air Force Engineering University, Xi\u2019an 710051, Shaanxi, China"
            },
            {
                "name": "Yongqiang Pang",
                "org": "College of Science, Air Force Engineering University, Xi\u2019an 710051, Shaanxi, China"
            },
            {
                "name": "Jie Yang",
                "org": "College of Science, Air Force Engineering University, Xi\u2019an 710051, Shaanxi, China"
            },
            {
                "name": "Ya Fan",
                "org": "College of Science, Air Force Engineering University, Xi\u2019an 710051, Shaanxi, China"
            },
            {
                "name": "Shaobo Qu",
                "org": "College of Science, Air Force Engineering University, Xi\u2019an 710051, Shaanxi, China"
            }
        ],
        "venue": "AIP Advances",
        "year": 2017
    },
    "R6MHqWkz": {
        "id": "R6MHqWkz",
        "title": "Enhancing Backward Scattering Using Metasurfaces",
        "abstract": "In this letter, we propose the design of metasurfaces for enhancing backscattering under oblique incidence. Through reflective phase profile design along the surface, an equivalent wave-vector can be generated, with double magnitude but opposite direction to the parallel component  $mathbf{k}_{Vert}$  of the wave-vector  $mathbf{k}_{0}$  of incident waves. A modified metallic square loop structure is used to achieve the required phase profile under oblique incidence. Through the phase gradient design, the metasurface can reflect incident waves backwards at 9.8GHz and the optimized frequency band can reach to 2.5GHz under transverse electric (TE) polarizations. Two prototypes were fabricated and measured. Both the simulation and experiment results verify the good backscattering enhancement performance of he metasurface.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuxiang Jia",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Jiafu Wang",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Yongfeng Li",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Yongqiang Pang",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Jie Yang",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Ya Fan",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Maochang Feng",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            },
            {
                "name": "Shaobo Qu",
                "org": "Air Force Engineering University, Xi'an, Shaanxi, 710051, China"
            }
        ],
        "venue": "international conference on microwave and millimeter wave technology",
        "year": 2018
    },
    "KYTBZmyn": {
        "id": "KYTBZmyn",
        "title": "Real-time waveform modulator based on dispersion engineering of magnetic surface plasmons",
        "abstract": "With the aim to further reduce insertion loss, we propose the design of a real-time waveform modulator by engineering the dispersion of magnetic surface plasmons (MSPs). The magnetic fields of MSPs are strongly localized, which is different from conventional electric surface plasmons (ESPs). Since there are no magnetic media in the design, the transmission loss of MSPs resulting from dielectric loss is lower than that of ESPs. Therefore, a waveform modulator with lower insertion loss can be realized. As an example, we demonstrate a real-time waveform modulator operating in the X band. Both the simulation and experiment prove that the waveform modulator is broadband and high-efficiency. The design method can also be applied to the design of a true-time delayer, a real-time Fourier transformer, a true-time compressor, and so on.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhuoluo Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an, Shaanxi 710051, People's Republic of China"
            },
            {
                "name": "Jiafu Wang",
                "org": "College of Science, Air Force Engineering University, Xi'an, Shaanxi 710051, People's Republic of China"
            },
            {
                "name": "Xin Wang",
                "org": "College of Missile, Air Force Engineering University, Xi'an, Shaanxi 710051, People's Republic of China"
            },
            {
                "name": "Jie Yang",
                "org": "College of Science, Air Force Engineering University, Xi'an, Shaanxi 710051, People's Republic of China"
            },
            {
                "name": "Yaodong Zhao",
                "org": "Science and Technology on Electronic Information Control Laboratory, Chengdu, Sichuan 610036, China"
            },
            {
                "name": "Jieqiu Zhang",
                "org": "College of Science, Air Force Engineering University, Xi'an, Shaanxi 710051, People's Republic of China"
            },
            {
                "name": "Hua Ma",
                "org": ""
            },
            {
                "name": "Shaobo Qu",
                "org": "College of Science, Air Force Engineering University, Xi'an, Shaanxi 710051, People's Republic of China"
            }
        ],
        "venue": "Journal of Applied Physics",
        "year": 2018
    },
    "GynC6UEP": {
        "id": "GynC6UEP",
        "title": "X-ray-activated long persistent phosphors featuring strong UVC afterglow emissions.",
        "abstract": "Phosphors emitting visible and near-infrared persistent luminescence have been explored extensively owing to their unusual properties and commercial interest in their applications such as glow-in-the-dark paints, optical information storage, and in vivo bioimaging. However, no persistent phosphor that features emissions in the ultraviolet C range (200-280\u2009nm) has been known to exist so far. Here, we demonstrate a strategy for creating a new generation of persistent phosphor that exhibits strong ultraviolet C emission with an initial power density over 10 milliwatts per square meter and an afterglow of more than 2\u2009h. Experimental characterizations coupled with first-principles calculations have revealed that structural defects associated with oxygen introduction-induced anion vacancies in fluoride elpasolite can function as electron traps, which capture and store a large number of electrons triggered by X-ray irradiation. Notably, we show that the ultraviolet C afterglow intensity of the yielded phosphor is sufficiently strong for sterilization. Our discovery of this ultraviolet C afterglow opens up new avenues for research on persistent phosphors, and it offers new perspectives on their applications in terms of sterilization, disinfection, drug release, cancer treatment, anti-counterfeiting, and beyond.",
        "keywords": "",
        "authors": [
            {
                "name": "Yan-Min Yang",
                "org": "1College of Physics Science and Technology, Hebei University, 071002 Baoding, China."
            },
            {
                "name": "Zhi-Yong Li",
                "org": "2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Jiangsu, China."
            },
            {
                "name": "Jun-Ying Zhang",
                "org": "3Department of Physics, Beihang University, 100191 Beijing, China."
            },
            {
                "name": "Yue Lu",
                "org": "3Department of Physics, Beihang University, 100191 Beijing, China."
            },
            {
                "name": "Shao-Qiang Guo",
                "org": "3Department of Physics, Beihang University, 100191 Beijing, China."
            },
            {
                "name": "Qing Zhao",
                "org": "4Department of Physical Science, Hiroshima University, Higashihiroshima, Hiroshima, 739-8526 Japan."
            },
            {
                "name": "Xin Wang",
                "org": "1College of Physics Science and Technology, Hebei University, 071002 Baoding, China."
            },
            {
                "name": "Zi-Jun Yong",
                "org": "2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Jiangsu, China."
            },
            {
                "name": "Hong Li",
                "org": "2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Jiangsu, China."
            },
            {
                "name": "Ju-Ping Ma",
                "org": "2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Jiangsu, China."
            },
            {
                "name": "Yoshihiro Kuroiwa",
                "org": "4Department of Physical Science, Hiroshima University, Higashihiroshima, Hiroshima, 739-8526 Japan."
            },
            {
                "name": "Chikako Moriyoshi",
                "org": "4Department of Physical Science, Hiroshima University, Higashihiroshima, Hiroshima, 739-8526 Japan."
            },
            {
                "name": "Li-Li Hu",
                "org": "5Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, 201800 Shanghai, China."
            },
            {
                "name": "Li-Yan Zhang",
                "org": "5Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, 201800 Shanghai, China."
            },
            {
                "name": "Li-Rong Zheng",
                "org": "6Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, 100049 Beijing, China."
            },
            {
                "name": "Hong-Tao Sun",
                "org": "2College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Jiangsu, China."
            }
        ],
        "venue": "Light, science & applications",
        "year": 2018
    },
    "JY2pA0mT": {
        "id": "JY2pA0mT",
        "title": "Insights into the local structure of dopants, doping efficiency, and luminescence properties of lanthanide-doped CsPbCl3 perovskite nanocrystals",
        "abstract": "Doping has been established as a powerful approach for endowing lead halide perovskite nanocrystals (NCs) with novel properties. However, our fundamental understanding of the local structure of dopants, doping efficiency and luminescence properties of these NCs is still very sparse. Here, we provide the first experimental evidence regarding the local structure of rare earth ions in CsPbCl3 NCs, based on the analysis of extended X-ray absorption fine structure spectroscopy. Our result suggests that Yb3+ occupies the Pb2+ crystallographic sites in CsPbCl3 NCs. We further demonstrate a strategy to examine the determinant of the doping efficiency in lanthanide-doped lead halide perovskite NCs, which enables us to uncover the important role of structural defects in affecting the doping efficiency. A broad range of experimental characterization techniques including steady-state and time-resolved luminescence spectra, X-ray absorption spectra, and positron annihilation lifetime spectra, coupled with first-principles calculations, help us identify that the doping efficiency is associated with structural defects in NCs and that the formation of a higher-concentration of defects favors incorporation of a higher-concentration of dopants into the lattice. Importantly, we demonstrate that the concept of defect-assisted doping is not limited to the model system of Yb3+-doped CsPbCl3 NCs, but can be used as a guideline to rationally tune the doping efficiency of lanthanide-doped halide perovskite NCs. We also show that lanthanide-doped CsPbCl3 NCs demonstrate anomalous decay of the band-edge emission, which we propose is due to the existence of shallow trapping states near the conduction band. Our results greatly deepen the understanding of the structural and photophysical properties of lanthanide-doped lead halide perovskite NCs, and highlight the possibility to use the chemistry of defects to tailor the doping efficiency of halide perovskite NCs.",
        "keywords": "",
        "authors": [
            {
                "name": "Ju-Ping Ma",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Ya-Meng Chen",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Lu-Min Zhang",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Shao-Qiang Guo",
                "org": "Department of Physics, Beihang University,Beijing 100191,China"
            },
            {
                "name": "Jian-Dang Liu",
                "org": "State Key Laboratory of Particle Detection and Electronics, Department of Modern Physics, University of Science and Technology of China,Hefei,P. R. China"
            },
            {
                "name": "Hong Li",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Bang-Jiao Ye",
                "org": "State Key Laboratory of Particle Detection and Electronics, Department of Modern Physics, University of Science and Technology of China,Hefei,P. R. China"
            },
            {
                "name": "Zhi-Yong Li",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Yang Zhou",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Yang Zhou",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Bin-Bin Zhang",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Osman M. Bakr",
                "org": "Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology (KAUST),Thuwal 23955-6900,Saudi Arabia"
            },
            {
                "name": "Jun-Ying Zhang",
                "org": "Department of Physics, Beihang University,Beijing 100191,China"
            },
            {
                "name": "Hong-Tao Sun",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            },
            {
                "name": "Hong-Tao Sun",
                "org": "College of Chemistry, Chemical Engineering and Materials Science, Soochow University,Suzhou 215123,China"
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2019
    },
    "G3XI8Tor": {
        "id": "G3XI8Tor",
        "title": "Transformation of Perovskite BaBiO 3 into Layered BaBiO 2.5 Crystals Featuring Unusual Chemical Bonding and Luminescence.",
        "abstract": "Engineering oxygen coordination environments of cations in oxides has received intense interest thanks to the opportunities for the discovery of novel oxides with unusual properties. Here we present the successful synthesis of stoichiometric layered BaBiO2.5 enabled by a non-topotactic phase transformation of perovskite BaBiO3. By analysing the synchrotron X-ray diffraction data using the maximum entropy method/Rietveld technique, we find that Bi forms unusual chemical bondings with four oxygen atoms, featuring one ionic bonding and three covalent bondings that results in an asymmetric coordination geometry. A broad range of photophysical characterizations reveal that this peculiar structure shows near-infrared luminescence differing from conventional Bi-bearing systems. Experimental and theoretical results lead us to propose the excitonic nature of luminescence. Our work highlights that synthesizing materials with uncommon Bi-O bonding and Bi coordination geometry provides a pathway to the discovery of systems with new functionalities. We envisage that this work could inspire interest for the exploration of a range of materials containing heavier p-block elements, offering prospects for the finding of systems with unusual properties.",
        "keywords": [
            "Bismuth",
            "Luminescence",
            "maximum entropy method",
            "phase transition",
            "structure"
        ],
        "authors": [
            {
                "name": "Hong Li",
                "org": "CHINA."
            },
            {
                "name": "Qing Zhao",
                "org": "JAPAN."
            },
            {
                "name": "Bo-Mei Liu",
                "org": "CHINA."
            },
            {
                "name": "Jun-Ying Zhang",
                "org": "CHINA."
            },
            {
                "name": "Zhi-Yong Li",
                "org": "CHINA."
            },
            {
                "name": "Shao-Qiang Guo",
                "org": "CHINA."
            },
            {
                "name": "Ju-Ping Ma",
                "org": "CHINA."
            },
            {
                "name": "Yoshihiro Kuroiwa",
                "org": "JAPAN."
            },
            {
                "name": "Chikako Moriyoshi",
                "org": "JAPAN."
            },
            {
                "name": "Li-Rong Zheng",
                "org": "CHINA."
            },
            {
                "name": "Hong-Tao Sun",
                "org": "Soochow University, College of Chemistry, Chemical Engineering and Materials Science, 199 Ren-Ai Road, Suzhou Industrial Park, 215123, Suzhou, CHINA."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2018
    },
    "ihh8vBEg": {
        "id": "ihh8vBEg",
        "title": "Defective [Bi 2 O 2 ] 2+ Layers Exhibiting Ultrabroad Near-Infrared Luminescence.",
        "abstract": "The Aurivillius phases have been routinely known as excellent ferroelectrics and have rarely been deemed as materials luminescing in the near-infrared region. Here we show that the Aurivillius phases can demonstrate broadband near-infrared luminescence covering the telecommunication and biological optical windows. Experimental characterizations of the model system of Bi2.14Sr0.75Ta2O9-x, combined with theoretical calculations, help us establish that the near-infrared luminescence originates from defective [Bi2O2]2+ layers. Importantly, we validate the generality of our finding based on the observations of a rich bank of near-infrared luminescence characteristics in other Aurivillius phases. Our work highlights that incorporating defects into infinitely repeating [Bi2O2]2+ layers can be used as a powerful tool to space-selectively impart unusual luminescence emitters to the Aurivillius-phase ferroelectrics, which not only offers an optical probe for the examination of defect states in ferroelectrics, but also provides possibilities for coupling of the ferroelectric property with near-infrared luminescence.",
        "keywords": [
            "Aurivillius phases",
            "bismuth",
            "luminescence",
            "perovskite phases"
        ],
        "authors": [
            {
                "name": "Hong Li",
                "org": "CHINA."
            },
            {
                "name": "Xiao-Fang Jia",
                "org": "CHINA."
            },
            {
                "name": "Qing Zhao",
                "org": "JAPAN."
            },
            {
                "name": "Ju-Ping Ma",
                "org": "CHINA."
            },
            {
                "name": "Jian-Dang Liu",
                "org": "CHINA."
            },
            {
                "name": "Bang-Jiao Ye",
                "org": "CHINA."
            },
            {
                "name": "Yoshihiro Kuroiwa",
                "org": "JAPAN."
            },
            {
                "name": "Chikako Moriyoshi",
                "org": "JAPAN."
            },
            {
                "name": "Zhi-Yong Li",
                "org": "CHINA."
            },
            {
                "name": "Qi Liu",
                "org": "CHINA."
            },
            {
                "name": "Jun-Ying Zhang",
                "org": "CHINA."
            },
            {
                "name": "Hong-Tao Sun",
                "org": "Soochow University, College of Chemistry, Chemical Engineering and Materials Science, 199 Ren-Ai Road, Suzhou Industrial Park, 215123, Suzhou, CHINA."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2019
    },
    "SmDJKukt": {
        "id": "SmDJKukt",
        "title": "Transformation of Perovskite BaBiO3 into Layered BaBiO2.5 Crystals Featuring Unusual Chemical Bonding and Luminescence",
        "abstract": "Coordination environment engineering : Layered stoichiometric BaBiO 2.5 , synthesized by nontopotactic transformation of perovskite BaBiO 3 , features an unusual electron\u2010density distribution and Bi\u2212O bonding situation featuring one ionic and three covalent bonds, which give rise to peculiar near\u2010infrared luminescence never seen before in any Bi\u2010containing system (see figure).",
        "keywords": "",
        "authors": [
            {
                "name": "Hong Li",
                "org": "College of Chemistry, Chemical Engineering and Materials Science; Soochow University; Suzhou 215123 P.R. China"
            },
            {
                "name": "Qing Zhao",
                "org": "Department of Physical Science; Hiroshima University; Higashihiroshima Hiroshima 739-8526 Japan"
            },
            {
                "name": "Bo-Mei Liu",
                "org": "College of Chemistry, Chemical Engineering and Materials Science; Soochow University; Suzhou 215123 P.R. China"
            },
            {
                "name": "Jun-Ying Zhang",
                "org": "Department of Physics; Beihang University; Beijing 100191 P.R. China"
            },
            {
                "name": "Zhi\u2010Yong Li",
                "org": "College of Chemistry, Chemical Engineering and Materials Science; Soochow University; Suzhou 215123 P.R. China"
            },
            {
                "name": "Shao-Qiang Guo",
                "org": "Department of Physics; Beihang University; Beijing 100191 P.R. China"
            },
            {
                "name": "Ju-Ping Ma",
                "org": "College of Chemistry, Chemical Engineering and Materials Science; Soochow University; Suzhou 215123 P.R. China"
            },
            {
                "name": "Yoshihiro Kuroiwa",
                "org": "Department of Physical Science; Hiroshima University; Higashihiroshima Hiroshima 739-8526 Japan"
            },
            {
                "name": "Chikako Moriyoshi",
                "org": "Department of Physical Science; Hiroshima University; Higashihiroshima Hiroshima 739-8526 Japan"
            },
            {
                "name": "Lirong Zheng",
                "org": "Beijing Synchrotron Radiation Facility; Institute of High Energy Physics; Chinese Academy of Sciences; Beijing 100049 P.R. China"
            },
            {
                "name": "Hong-Tao Sun",
                "org": ""
            }
        ],
        "venue": "Chemistry: A European Journal",
        "year": 2018
    },
    "uuQpQTpv": {
        "id": "uuQpQTpv",
        "title": "Towards energy-efficient code dissemination in wireless sensor networks",
        "authors": [
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            },
            {
                "name": "Weijia Li"
            }
        ],
        "venue": "ipdps",
        "keywords": [
            "update-conscious compilation technique",
            "wireless sensor network",
            "wireless sensor networks",
            "update-conscious register allocation",
            "energy-efficient code dissemination",
            "energy efficient",
            "computer networks",
            "energy efficiency",
            "register allocation",
            "binary codes",
            "data acquisition",
            "user generated content",
            "remote sensing"
        ],
        "year": 2008
    },
    "0iiuOtaY": {
        "id": "0iiuOtaY",
        "title": "FPB: Fine-grained Power Budgeting to Improve Write Throughput of Multi-level Cell Phase Change Memory",
        "abstract": "As a promising nonvolatile memory technology, Phase Change Memory (PCM) has many advantages over traditional DRAM. Multi-level Cell PCM (MLC) has the benefit of increased memory capacity with low fabrication cost. Due to high per-cell write power and long write latency, MLC PCM requires careful power management to ensure write reliability. Unfortunately, existing power management schemes applied to MLC PCM result in low write throughput and large performance degradation. In this paper, we propose Fine-grained write Power Budgeting (FPB) for MLC PCM. We first identify two major problems for MLC write operations: (i) managing write power without consideration of the iterative write process used by MLC is overly pessimistic, (ii) a heavily written (hot) chip may block the memory from accepting further writes due to chip power restrictions, although most chips may be available. To address these problems, we propose two FPB schemes. First, FPB-IPM observes a global power budget and regulates power across write iterations according to the step-down power demand of each iteration. Second, FPB-GCP integrates a global charge pump on a DIMM to boost power for hot PCM chips while staying within the global power budget. Our experimental results show that these techniques achieve significant improvement on write throughput and system performance. Our schemes also interact positively with PCM effective read latency reduction techniques, such as write cancellation, write pausing and write truncation.",
        "keywords": [
            "global power budget",
            "power budget",
            "power management",
            "integrated circuit reliability",
            "write throughput",
            "multilevel cell pcm",
            "mlc pcm",
            "nonvolatile memory technology",
            "write truncation",
            "careful power management",
            "low fabrication cost",
            "phase change memories",
            "chip power restriction",
            "multiple level cell",
            "multi-level cell pcm",
            "fpb schemes",
            "power management schemes",
            "multilevel cell phase change memory",
            "fine-grained write power budgeting",
            "long write latency",
            "dram chips",
            "write cancellation",
            "high per-cell write power",
            "fine-grained power budgeting",
            "dram",
            "write pausing",
            "improve write throughput",
            "pcm effective read latency",
            "mlc pcm result",
            "phase change memory",
            "step-down power demand",
            "multi-level cell phase",
            "pcm effective read latency reduction techniques",
            "hot pcm chip",
            "memory capacity",
            "existing power management scheme",
            "change memory",
            "write reliability"
        ],
        "authors": [
            {
                "name": "Lei Jiang",
                "org": ""
            },
            {
                "name": "Youtao Zhang",
                "org": ""
            },
            {
                "name": "Bruce R. Childers",
                "org": ""
            },
            {
                "name": "Jun Yang",
                "org": ""
            }
        ],
        "venue": "MICRO",
        "year": 2012
    },
    "IojLtqYD": {
        "id": "IojLtqYD",
        "title": "MRAC: A Memristor-based Reconfigurable Framework for Adaptive Cache Replacement",
        "authors": [
            {
                "name": "Ping Zhou"
            },
            {
                "name": "Bo Zhao"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            },
            {
                "name": "Yiran Chen"
            }
        ],
        "venue": "pact",
        "keywords": [
            "non-volatile memory technology",
            "memristor-based reconfigurable framework",
            "non-conventional use",
            "cache replacement policy",
            "adaptive cache replacement",
            "robust performance improvement",
            "memory cell",
            "better performance",
            "memristor-based saturation counter",
            "counter design",
            "cache replacement framework",
            "cache access history",
            "radiation detector",
            "radiation detectors",
            "base saturation",
            "memristor",
            "computer architecture",
            "memristors",
            "robustness",
            "history",
            "non volatile memory",
            "resistance"
        ],
        "year": 2011
    },
    "lahyA09D": {
        "id": "lahyA09D",
        "title": "Proactive recovery for BTI in high-k SRAM cells.",
        "authors": [
            {
                "name": "Lin Li"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "date",
        "keywords": [
            "reliability",
            "transistors",
            "sram",
            "failure analysis",
            "logic gates",
            "high k",
            "stress",
            "nbti",
            "recovery",
            "logic gate",
            "nmos",
            "pmos",
            "degradation",
            "l2 cache"
        ],
        "year": 2011
    },
    "OVPucmm9": {
        "id": "OVPucmm9",
        "title": "Adaptive Buffer Management for Efficient Code Dissemination in Multi-Application Wireless Sensor Networks",
        "authors": [
            {
                "name": "Weijia Li"
            },
            {
                "name": "Yu Du"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Bruce Childers"
            },
            {
                "name": "Ping Zhou"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "euc (1)",
        "keywords": [
            "multi-application wireless sensor networks",
            "adaptive buffer management",
            "pervasive computing system",
            "human intervention",
            "efficient code dissemination",
            "wireless communication",
            "sensors",
            "protocols",
            "energy efficient",
            "wireless sensor networks",
            "wireless sensor network",
            "energy efficiency"
        ],
        "year": 2008
    },
    "qJTBjpDo": {
        "id": "qJTBjpDo",
        "title": "InfoShield: a security architecture for protecting information usage in memory",
        "authors": [
            {
                "name": "Weidong Shi"
            },
            {
                "name": "Joshua B. Fryman"
            },
            {
                "name": "Guofei Gu"
            },
            {
                "name": "Hsien-hsin S. Lee"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "hpca",
        "keywords": [
            "e commerce",
            "security architecture",
            "data privacy",
            "client server",
            "non volatile memory",
            "internet security"
        ],
        "year": 2006
    },
    "yIsjmAxD": {
        "id": "yIsjmAxD",
        "title": "A speculative arbiter design to enable high-frequency many-VC router in NoCs",
        "authors": [
            {
                "name": "Bo Zhao"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "nocs",
        "keywords": [
            "network throughput",
            "arbitration latency",
            "high vc occupancy",
            "network on chip routers",
            "reduced router clock frequency",
            "speculative arbiter design",
            "zero load latency",
            "high frequency many virtual channel router",
            "speculation opportunity",
            "many vc routers",
            "high frequency many input arbiter design",
            "noc",
            "network-on-chip",
            "arbitration complexity",
            "throughput",
            "routing",
            "network on chip",
            "organizations"
        ],
        "year": 2013
    },
    "IcnB9CFF": {
        "id": "IcnB9CFF",
        "title": "Frequent value locality and value-centric data cache design",
        "authors": [
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            },
            {
                "name": "Rajiv Gupta"
            }
        ],
        "venue": "asplos",
        "keywords": [
            "random access"
        ],
        "year": 2000
    },
    "7vdiZV6A": {
        "id": "7vdiZV6A",
        "title": "UCC: update-conscious compilation for energy efficiency in wireless sensor networks",
        "authors": [
            {
                "name": "Weijia Li",
                "org": "Computer Science Department|University of Pittsburgh"
            },
            {
                "name": "Youtao Zhang",
                "org": "Computer Science Department|University of Pittsburgh"
            },
            {
                "name": "Jun Yang",
                "org": "Computer Science Department|University of Pittsburgh"
            },
            {
                "name": "Jiang Zheng",
                "org": "Computer Science Department|University of Pittsburgh"
            }
        ],
        "venue": "sigplan notices",
        "keywords": [
            "register allocation",
            "sensor networks",
            "code dissemina- tion"
        ],
        "year": 2007
    },
    "AK0DQQbz": {
        "id": "AK0DQQbz",
        "title": "Dynamic Authentication-Key Re-assignment for Reliable Report Delivery",
        "authors": [
            {
                "name": "Weijia Li"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "mass",
        "keywords": [
            "multipath routing",
            "sensor network",
            "telecommunication network reliability",
            "annulus based authentication-key reassignment scheme",
            "reliable report delivery",
            "packet dropping",
            "wireless sensor networks",
            "telecommunication security",
            "telecommunication network routing",
            "message authentication",
            "hostile environment"
        ],
        "year": 2006
    },
    "eaqIGaK2": {
        "id": "eaqIGaK2",
        "title": "Thermal Management for 3D Processors via Task Scheduling",
        "authors": [
            {
                "name": "Xiuyi Zhou"
            },
            {
                "name": "Yi Xu"
            },
            {
                "name": "Yu Du"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "icpp",
        "keywords": [
            "task scheduling",
            "device density",
            "chip performance",
            "chip temperature low",
            "increased power density",
            "thermal management",
            "inherent thermal variation",
            "hardware dtms",
            "proposed algorithm",
            "chip fabrication",
            "high temperature",
            "os-level scheduling algorithm",
            "task analysis",
            "heating",
            "stacking",
            "switches",
            "scheduling",
            "chip",
            "scheduling algorithm",
            "power density",
            "hardware"
        ],
        "year": 2008
    },
    "gVSNNtRm": {
        "id": "gVSNNtRm",
        "title": "Throughput Enhancement for Phase Change Memories",
        "authors": [
            {
                "name": "Ping Zhou"
            },
            {
                "name": "Bo Zhao"
            },
            {
                "name": "Jun Yang"
            },
            {
                "name": "Youtao Zhang"
            }
        ],
        "venue": "ieee trans. computers",
        "keywords": [
            "memory scheduling",
            "phase change memories",
            "zero cell leakage",
            "serial operations",
            "pcm",
            "multiprocessing systems",
            "intrabank parallelism",
            "deep submicron technologies",
            "limited endurance",
            "low power",
            "nonblocking hardware",
            "high cell density",
            "phase change memory",
            "memory request scheduling algorithms",
            "throughput enhancement"
        ],
        "year": 2013
    },
    "XWK70SDQ": {
        "id": "XWK70SDQ",
        "title": "WoM-SET: low power proactive-SET-based PCM write using WoM code",
        "authors": [
            {
                "name": "XianWei Zhang"
            },
            {
                "name": "Le Jang"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Chuanjun Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "islped",
        "keywords": [
            "low power proactive-set",
            "design",
            "phase change memory",
            "performance analysis and design aids",
            "experimentation",
            "reset bit reduction",
            "asymmetric write characteristic",
            "energy-delay-product improvement",
            "phase change memories",
            "write-once memory",
            "low-power electronics",
            "pcm write",
            "measurement",
            "write-intensive pages",
            "electronics",
            "write power demand",
            "wom code",
            "preset scheme",
            "wom-set",
            "performance",
            "write-once storage",
            "low power electronics"
        ],
        "year": 2013
    },
    "wKhl4CiT": {
        "id": "wKhl4CiT",
        "title": "A low-radix and low-diameter 3D interconnection network design",
        "authors": [
            {
                "name": "Yi Xu"
            },
            {
                "name": "Yu Du"
            },
            {
                "name": "Bo Zhao"
            },
            {
                "name": "Xiuyi Zhou"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "hpca",
        "keywords": [
            "network routing",
            "topology",
            "logic design",
            "mesh network",
            "routing",
            "network on chip",
            "network topology",
            "chip"
        ],
        "year": 2009
    },
    "TWGuYwAf": {
        "id": "TWGuYwAf",
        "title": "Fine-grained QoS scheduling for PCM-based main memory systems",
        "authors": [
            {
                "name": "Ping Zhou"
            },
            {
                "name": "Yu Du"
            },
            {
                "name": "Youtao Zhang"
            },
            {
                "name": "Jun Yang"
            }
        ],
        "venue": "ipdps",
        "keywords": [
            "phase change memory",
            "scheduling",
            "fine-grained qos scheduling",
            "large capacity main memory systems",
            "quality-of-service",
            "quality of service",
            "memory scheduling",
            "storage management",
            "pcm bank service time",
            "row buffer partition",
            "request preemption",
            "concurrent applications",
            "chip multiprocessors",
            "request queuing time",
            "pcm-based main memory systems",
            "application software",
            "memory management",
            "interference",
            "bandwidth"
        ],
        "year": 2010
    },
    "OtIqJMJb": {
        "id": "OtIqJMJb",
        "title": "Performance-aware thermal management via task scheduling",
        "authors": [
            {
                "name": "Xiuyi Zhou",
                "org": "University of Pittsburgh, Pittsburgh, PA"
            },
            {
                "name": "Jun Yang"
            },
            {
                "name": "Marek Chrobak",
                "org": "University of California, Riverside, CA"
            },
            {
                "name": "Youtao Zhang",
                "org": "University of Pittsburgh, Pittsburgh, PA"
            }
        ],
        "venue": "taco",
        "keywords": [
            "os-level technique",
            "real-system implementation",
            "hardware dtms",
            "high on-chip temperature",
            "hardware-level dynamic thermal management",
            "performance-aware thermal management",
            "task scheduling",
            "thermal management",
            "cpu throughput",
            "severe thermal environment",
            "chip temperature",
            "medium thermal environment",
            "cool job",
            "chip",
            "job scheduling"
        ],
        "year": 2010
    },
    "y0rGLde0": {
        "id": "y0rGLde0",
        "title": "A durable and energy efficient main memory using phase change memory technology",
        "authors": [
            {
                "name": "Ping Zhou",
                "org": "University of Pittsburgh, Pittsburgh, PA, USA"
            },
            {
                "name": "Bo Zhao",
                "org": "University of Pittsburgh, Pittsburgh, PA, USA"
            },
            {
                "name": "Jun Yang",
                "org": "University of Pittsburgh, Pittsburgh, PA, USA"
            },
            {
                "name": "Youtao Zhang",
                "org": "University of Pittsburgh, Pittsburgh, PA, USA"
            }
        ],
        "venue": "proceedings of the 40th annual international symposium on computer architecture",
        "keywords": [
            "non volatile memory",
            "energy efficient",
            "chip",
            "nonvolatile memory",
            "phase change memory"
        ],
        "year": 2009
    },
    "AG2sYAiL": {
        "id": "AG2sYAiL",
        "title": "Reduce Register Files Leakage Through Discharging Cells",
        "authors": [
            {
                "name": "Lingling Jin"
            },
            {
                "name": "Wei Wu"
            },
            {
                "name": "Jun Yang"
            },
            {
                "name": "Chuanjun Zhang"
            },
            {
                "name": "Youtao Zhang"
            }
        ],
        "venue": "iccd",
        "keywords": [
            "electrical faults",
            "superscalar processor",
            "reduce register files leakage",
            "discharging cells",
            "fault diagnosis",
            "life cycles",
            "secondary cells",
            "leakage current",
            "register file",
            "life cycle"
        ],
        "year": 2007
    },
    "k5Rh7weH": {
        "authors": [
            {
                "name": "Qingke Bai",
                "org": "Department of Neurology"
            },
            {
                "name": "Zhenguo Zhao",
                "org": "Department of Radiology"
            },
            {
                "name": "Paul Fu",
                "org": "Department of Neurological Surgery"
            },
            {
                "name": "Haijing Sui",
                "org": "Department of Radiology"
            },
            {
                "name": "Xiuhai Xie",
                "org": "Department of Radiology"
            },
            {
                "name": "Juan Chen",
                "org": "Department of Neurology"
            },
            {
                "name": "Juan Yang",
                "org": "Department of Neurology"
            }
        ],
        "title": "Clinical outcomes of fast MRI-based trombolysis in wake-up strokes compared to superacute ischemic strokes within 12 hours",
        "keywords": [
            "Acute ischemic stroke",
            "Magnetic resonance imaging",
            "Thrombolysis",
            "Wake-Up Ischemic Strokes"
        ],
        "venue": "Neurological Research",
        "year": 2013,
        "id": "k5Rh7weH"
    },
    "sClQLFvk": {
        "authors": [
            {
                "name": "Qingke Bai",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Zhenguo Zhao",
                "org": "Department of Radiology, Pudong People's Hospital"
            },
            {
                "name": "Haijing Sui",
                "org": "Department of Radiology, Pudong People's Hospital"
            },
            {
                "name": "Xiuhai Xie",
                "org": "Department of Radiology, Pudong People's Hospital"
            },
            {
                "name": "Juan Chen",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Juan Yang",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Yuan Zhou",
                "org": "Department of Neurology, Pudong People's Hospital"
            }
        ],
        "title": "Comparison of fast MRI-based individual thrombolysis therapy for patients with superacute infarction",
        "keywords": [
            "Magnetic resonance imaging",
            "recombinant tissue plasminogen activator",
            "stroke",
            "thrombolysis"
        ],
        "venue": "Journal of Stroke and Cerebrovascular Diseases",
        "year": 2014,
        "id": "sClQLFvk"
    },
    "LtRp5dFF": {
        "authors": [
            {
                "name": "Juan Yang",
                "org": "Department of Neurology"
            },
            {
                "name": "Xiao-Hui Zhao",
                "org": "Department of Neurology"
            },
            {
                "name": "Yu-Ping Zhu",
                "org": "Department of Neurology"
            },
            {
                "name": "Qing-Ke Bai",
                "org": "Department of Neurology"
            },
            {
                "name": "Juan Chen",
                "org": "Department of Neurology"
            },
            {
                "name": "Wei-Ying Xia",
                "org": "Department of Neurology"
            },
            {
                "name": "Lian-Jun Chen",
                "org": "Department of Neurology"
            },
            {
                "name": "Tong-Shun Lin",
                "org": "Department of Neurology"
            }
        ],
        "title": "Therapeutic effect of paroxetine on patients with early poststroke depression and the serum interleukins",
        "keywords": [
            "Depression",
            "Interleukin-1 beta",
            "Interleukin-6",
            "Paroxetine",
            "Stroke",
            "Treatment outcome"
        ],
        "venue": "Chinese Journal of Cerebrovascular Diseases",
        "year": 2011,
        "id": "LtRp5dFF"
    },
    "yLH90z7D": {
        "authors": [
            {
                "name": "Qingke Bai",
                "org": ""
            },
            {
                "name": "Zhenguo Zhao",
                "org": ""
            },
            {
                "name": "Haijing Sui",
                "org": ""
            },
            {
                "name": "Xiuhai Xie",
                "org": ""
            },
            {
                "name": "Juan Chen",
                "org": ""
            },
            {
                "name": "Juan Yang",
                "org": ""
            },
            {
                "name": "Li Zhang",
                "org": ""
            }
        ],
        "title": "Susceptibility-weighted imaging for cerebral microbleed detection in super-acute ischemic stroke patients treated with intravenous thrombolysis",
        "keywords": [
            "Cerebral microbleeds",
            "Ischemic stroke",
            "Magnetic resonance imaging",
            "Susceptibility-weighted imaging",
            "Thrombolysis"
        ],
        "venue": "Neurological Research",
        "year": 2013,
        "id": "yLH90z7D"
    },
    "Q95Aedwl": {
        "authors": [
            {
                "name": "Qingke Bai",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Zhenguo Zhao",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Haijing Sui",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Xiuhai Xie",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Juan Chen",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Juan Yang",
                "org": "Department of Neurology, Pudong People's Hospital"
            },
            {
                "name": "Yuan Zhou",
                "org": "Department of Neurology, Pudong People's Hospital"
            }
        ],
        "title": "Fast magnetic resonance imaging-based thrombolysis in patients with wake-up ischemic strokes",
        "keywords": [
            "Brain ischemia",
            "Magnetic resonance imaging",
            "Stroke",
            "Thrombolytic therapy",
            "Tissue plasminogen activator"
        ],
        "venue": "Chinese Journal of Neurology",
        "year": 2014,
        "id": "Q95Aedwl"
    },
    "GeFPbHFB": {
        "authors": [
            {
                "name": "Chunfang Tang",
                "org": ""
            },
            {
                "name": "Lindan Wang",
                "org": ""
            },
            {
                "name": "Qian Chen",
                "org": ""
            },
            {
                "name": "Xiaojuan Zhu",
                "org": ""
            }
        ],
        "title": "Study of adsorption characteristics of activated carbon to chromium from aquatic solution",
        "abstract": "Cr(VI) has posed great threat on environmental safety and human health, thus the remediation of Cr(VI) pollution is of considerable importance. The adsorption of Cr(VI) from aquatic solution using activated carbon was studied in this paper. The Cr(VI) sorption was relative to pH, contact time, initial content of solution, adsorbent dose and temperature. The maximum removal efficiencies of Cr(VI) were 97.67%. The maximum adsorption capacity was found to be 4.75 mg/kg. Thermodynamic indexes indicate that the adsorption process was endothermic and spontaneous. Freundlich adsorption isotherm model was fitted well the equilibrium data for the adsorption. The Cr(VI) uptake was best described by pseudo second-order rate model. \u00a9 2011 IEEE.",
        "keywords": [
            "Activated carbon",
            "Adsorption characteristica",
            "Isotherm",
            "Kinetics",
            "Thermodynamics"
        ],
        "venue": "Proceedings - International Conference on Computer Distributed Control and Intelligent Environmental Monitoring, CDCIEM 2011",
        "year": 2011,
        "id": "GeFPbHFB"
    },
    "sUPFhY89": {
        "authors": [
            {
                "name": "Qian Chen",
                "org": "College of civil engineering"
            },
            {
                "name": "Lingyong Liu",
                "org": "College of civil construction and mechanics"
            },
            {
                "name": "Yangjun Meng",
                "org": "College of civil engineering"
            }
        ],
        "title": "Experimental study on reinforcement of failure reinforced concrete beams",
        "abstract": "Through repair and reinforcement of breaking reinforced concrete beams by epoxy resin and carbon cloth, and its experiment, the crack and deformation and bearing capacity as well as ductility of such beams are obtained. Experimental results show that the ultimate bearing capacity of beams after reinforcement increased by 210%, the structure ductility fell by 170%, structural failure form is similar to failure in normal cross section. \u00a9 (2013) Trans Tech Publications, Switzerland.",
        "keywords": [
            "Carbon cloth",
            "Experiment",
            "Failure",
            "Reinforced concrete beam",
            "Reinforcement"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2013,
        "id": "sUPFhY89"
    },
    "UxZGOAOO": {
        "authors": [
            {
                "name": "Jin He",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Tao Guo",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Xue-Hui Sun",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Cui-Chen Zhou",
                "org": "Department of Pharmacy"
            }
        ],
        "title": "Studies on the tissue distribution of intravenous emulsion of garlic oil in rats",
        "abstract": "OBJECTIVE: To study the tissue distribution of intravenous emulsion of garlic oil(GO-E) in rats. METHODS A single dose of GO-E or Co-INJ was administered to 36 healthy rats via the jugular vein. The tissues of heart , liver, spleen, lung, kidney and brain were acquired at 5, 30 or 60 min after administration. GC-ECD was used to determine the concentration of DADS or DATS in the tissues of rats. Controlled by garlic oil injection(GO-INJ), the comparative stadies on the distributions of the tissues in the heart, liver, spleen, lung, kidney, brain were performed. RESULTS: The distribution of DADS had an advangtage in rat tissues after the administration of two formulations. DADS and DATS of two formulations were distributed in lung, kidney, brain and heart at 5min after administration. The distribution of two components of GO-E in liver was more than that of GO-INJ. The total concentration of DADS and DATS of two formulations were gradually reduced in tissues at 30 min after administration. The total concentration of DADS and DATS of GO-E had an advangtage over that of GO-INJ at 60 min after administration. CONCLUSION: Compared with GO-INJ, the residence time of GO-E was longer in tissues. GO-E possess an effect of sustained release to some extent. The effect of passive target is not obvious.",
        "keywords": [
            "DADS",
            "DATS",
            "GC-ECD",
            "Tissue distribution"
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2010,
        "id": "UxZGOAOO"
    },
    "PzyYm1Kf": {
        "authors": [
            {
                "name": "Zhi-Yuan Wang",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Tao Guo",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Hong-Tao Song",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Jin He",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Ming Yan",
                "org": "Department of Pharmacy"
            }
        ],
        "title": "Study on the GC fingerprint of inclusion complexes of garlic oil with hydroxypropyl-\u03b2-cyclodextrin for injection",
        "abstract": "Objective: To establish the GC fingerprint of inclusion complexes of garlic oil with hydroxypropyl-\u03b2-cyclodextrin (HP-\u03b2-CD) for injection. Methods: GC was performed on HP-5 capillary column (30 m \u00d7 320 \u03bcm, 0.25 \u03bcm). The column temperature was 60-170 \u00b0C and rose by program at the rate of 8 \u00b0C/min. N",
        "keywords": [
            "Beta-cyclodextrins",
            "Chromatography, gas",
            "Fingerprint",
            "Garlic oil",
            "Inclusion complexes",
            "Injections",
            "Intravenous"
        ],
        "venue": "Pharmaceutical Care and Research",
        "year": 2007,
        "id": "PzyYm1Kf"
    },
    "zR2RmNk2": {
        "authors": [
            {
                "name": "Xuehui Sun",
                "org": "Shenyang Pharmaceutical University"
            },
            {
                "name": "Tao Guo",
                "org": "General Hospital of Shenyang Military Region"
            },
            {
                "name": "Jin He",
                "org": "General Hospital of Shenyang Military Region"
            },
            {
                "name": "Minghong Zhao",
                "org": "General Hospital of Shenyang Military Region"
            },
            {
                "name": "Ming Yan",
                "org": "General Hospital of Shenyang Military Region"
            },
            {
                "name": "Fude Cui",
                "org": "Shenyang Pharmaceutical University"
            },
            {
                "name": "Yihui Deng",
                "org": "Shenyang Pharmaceutical University"
            }
        ],
        "title": "Determination of the concentration of diallyl trisulfide in rat whole blood using gas chromatography with electron-capture detection and identification of its major metabolite with gas chromatography mass spectrometry",
        "abstract": "A simple, rapid, and sensitive procedure has been developed using gas chromatography with electron-capture detection to measure diallyl trisulfide levels in rat blood. Blood samples were acidified, and the analyte was extracted with hexane, and then degradation was stopped with acetonitrile before gas chromatographic separation. Two calibration curves were linear over the range of 10-500 ng/ml and 0.2-20 \u03bcg/ml, with typical r values of 0.9986 and 0.9993, respectively. The structure of its major metabolite was confirmed using combined gas chromatography-mass spectrometry. The limit of detection was less than 10 ng/ml, and the assay was highly reproducible, giving peaks with excellent chromatographic properties. The method is suitable for pharmacokinetic and therapeutic purposes. \u00a9 2006 The Pharmaceutical Society of Japan.",
        "keywords": [
            "Diallyl disulfide",
            "Diallyl trisulfide",
            "Electron-capture gas chromatography",
            "Gas chromatography-mass spectrometry"
        ],
        "venue": "Yakugaku Zasshi",
        "year": 2006,
        "id": "zR2RmNk2"
    },
    "krdXLdo8": {
        "authors": [
            {
                "name": "Xue-Hui Sun",
                "org": "Shenyang Pharmaceutical University"
            },
            {
                "name": "Tao Guo",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Jin He",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Ming-Hong Zhao",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Shu-Fang Nie",
                "org": "Shenyang Pharmaceutical University"
            },
            {
                "name": "Xin-Xin Liu",
                "org": "Dalian Medical University"
            }
        ],
        "title": "Pharmacokinetics of solid lipid nanoparticles containing garlic oil in rats",
        "abstract": "OBJECTIVE: To establish a GC-ECD method for simultaneously measuring the DATS and DADS levels in rat blood and to study the pharmacokinetics of solid lipid nanoparticles and injection containing garlic oil in rats. METHODS: A single dose of GO-SLN and GO injection (containing 10 mg garlic oil) was administered to 12 healthy rats via the jugular vein. The concentrations of DATS and DADS in blood were simultaneously measured by GC-ECD. The pharmacokinetic parameters of solid lipid nanoparticle and injection containing garlic oil were calculated by program DAS2. 0. RESULTS: DATS in garlic oil was first transformed into DADS and then degraded continuously after administration of two formulations via the jugular vein. The MRTs of DATS and DADS in GO-SLN were 7.3 and 16.9 min while the \u03c1",
        "keywords": [
            "Diallyl disulfide",
            "Diallyl trisulfide",
            "Electron-capture gas chromatography",
            "Garlic oil",
            "Pharmacokinetics",
            "Solid lipid nanoparticles"
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2007,
        "id": "krdXLdo8"
    },
    "UBAUxbfb": {
        "authors": [
            {
                "name": "Tao Guo",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Xiao-Qin Chu",
                "org": "Shenyang Pharmaceutical University"
            },
            {
                "name": "Hong-Tao Song",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Yi-Hui Deng",
                "org": "Shenyang Pharmaceutical University"
            },
            {
                "name": "Jin He",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Xue-Hui Sun",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Ming Yan",
                "org": "Department of Pharmacy"
            }
        ],
        "title": "Preparation of garlic oil submicron emulsion for intravenous administration",
        "abstract": "OBJECTIVE: To prepare garlic oil submicron emulsion for intravenous administration. METHODS: The garlic oil submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer. The physical and chemical stability of emulsions were evaluated with the stability parameters of centrifugation, content of garlicin and appearance of emulsion. The optimized formulation was established by orthogonal experimental design, and processing factors were studied based on the optimized formulation. RESULTS: The garlic oil submicron emulsion with good and stable quality was prepared by controlling various processing factors. The intensity-weighted particle size distribution of garlic oil submicron emulsion was( 150.4 \u00b1 14.6)nm. CONCLUSION: The garlic oil submicron emulsion made by this optimum formulation and preparative technique was fitted to be used for intravenous administration.",
        "keywords": [
            "Garlic oil",
            "High pressure homogenization",
            "Submicron emulsion"
        ],
        "venue": "Chinese Pharmaceutical Journal",
        "year": 2005,
        "id": "UBAUxbfb"
    },
    "saSZEGjw": {
        "authors": [
            {
                "name": "Hong-Tao Song",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Tao Guo",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Yue-Xin Zhang",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Wei Han",
                "org": "School of Pharmacy"
            },
            {
                "name": "Zhi-Yuan Wang",
                "org": "School of Pharmacy"
            },
            {
                "name": "Jin He",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Zhong-Gui He",
                "org": "School of Pharmacy"
            }
        ],
        "title": "Effect of 2-hydroxypropyl-\u03b2-cyclodextrin on solubility and stability of garlic oil",
        "abstract": "Objective: To investigate the effects of 2-hydroxypropyl-\u03b2-cyclodextrin (HP-\u03b2-CD) on the solubility and stability of garlic oil. Methods: The solubility of allicin of garlic oil in various concentration of HP-\u03b2-CD water solution was determined by GC. The content of allicin was used as an index to compare the stability of garlic oil HP-\u03b2-CD water solution with garlic oil Tween-80 water solution under the conditions of 40 \u00b0C, 60 \u00b0C, and light (4 500 lx). The effects of pH value, antioxidants, nitrogen gas, and sterilizing on the stability of allicin of garlic oil in 5% HP-\u03b2-CD water solution were investigated. Results: The solubility of allicin of garlic oil in water could be improved remarkably by HP-\u03b2-CD and increased linearly along with the increasing of HP-\u03b2-CD concentration. The allicin of garlic oil was more stable in HP-\u03b2-CD water solution than in Tween-80 water solution while in pH value 5.0 and with nitrogen gas. The stablity of allicin of garlic oil was decreased under the conditions of heating, lighting, or adding antioxidants. Conclusion: HP-\u03b2-CD could evidently increase the solubility of allicin of garlic oil in water and improve its stability.",
        "keywords": [
            "2-hydroxypropyl-\u03b2-cyclodextrin (HP-\u03b2-CD)",
            "Allicin",
            "Garlic oil",
            "Solubility",
            "Stability"
        ],
        "venue": "Chinese Traditional and Herbal Drugs",
        "year": 2006,
        "id": "saSZEGjw"
    },
    "fDK0Enrq": {
        "authors": [
            {
                "name": "Xue-Hui Sun",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Tao Guo",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Jin He",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Ming-Hong Zhao",
                "org": "Department of Pharmacy"
            },
            {
                "name": "Shu-Fang Nie",
                "org": "Shenyang Pharmaceutical University"
            }
        ],
        "title": "Tissue distribution of solid lipid nanoparticles loaded garlic oil in rats",
        "abstract": "Objective: To investigate the tissue distribution of the diallyl disulfide (DADS) and diallyl trisulfide (DATS) in solid lipid nanoparticles loaded garlic oil (GO-SLN) in rats. Method; The gas chromatography-electron capture detection (GC-ECD) method was established to determined the DADS and DATS simultaneously in the biological samples of rats after administration of 0. 5 mL garlic oil injection or GO-SLN (containing about 10 mg garlic oil) via jugular vein cannula. The conditions for gas chromatographic separation were as follows. The oven temperature was set at 110 \u00b0C and maintained for 15 min. Temperatures at the injection port and detector were 180 \u00b0 C and 300 \u00b0C, respectively. Ultra-pure nitrogen (purity > 99. 999%, Shenyang Kerui Special Gases Co. Ltd.,China) was used as a carrier gas and made-up gas at flow-rates of 1 mL \u00b7 min",
        "keywords": [
            "Diallyl disulfide",
            "Diallyl trisulfide",
            "Electron-capture gas chromatography",
            "Garlic oil",
            "Solid lipid nanoparticles",
            "Tissue distribution"
        ],
        "venue": "Zhongguo Zhongyao Zazhi",
        "year": 2008,
        "id": "fDK0Enrq"
    },
    "9Z2AhUM0": {
        "authors": [
            {
                "name": "Qianga Liu",
                "org": "Municipal and Environment Engineering Institute"
            },
            {
                "name": "Yulan Tang",
                "org": "Municipal and Environment Engineering Institute"
            },
            {
                "name": "Jinxing Fu",
                "org": "Municipal and Environment Engineering Institute"
            },
            {
                "name": "Yuhua Zhao",
                "org": "Municipal and Environment Engineering Institute"
            },
            {
                "name": "Zhi Wang",
                "org": "Municipal and Environment Engineering Institute"
            }
        ],
        "title": "Pilot study on removal and recovery of nitrogen and phosphorus in human urine by crystallization of magnesium ammonium phosphate",
        "abstract": "Laboratory-scale tests for removal and recovery of nitrogen and phosphorus in human urine were conducted by magnesium ammonium phosphate precipitation (MAP) method. Proper Na",
        "keywords": [
            "Magnesium ammonium phosphate precipitation method (MAP)",
            "Nitrogen and phosphorus recovery",
            "Urine removal"
        ],
        "venue": "Advanced Materials Research",
        "year": 2010,
        "id": "9Z2AhUM0"
    },
    "yRcQNZaK": {
        "authors": [
            {
                "name": "Jinxiang Fu",
                "org": "School of Municipal and Environmental Engineering"
            },
            {
                "name": "Pengfei Yu",
                "org": "School of Municipal and Environmental Engineering"
            },
            {
                "name": "Ming Qu",
                "org": "Fushun Water Company"
            },
            {
                "name": "Zhi Wang",
                "org": "School of Municipal and Environmental Engineering"
            },
            {
                "name": "Tianren Wu",
                "org": "School of Municipal and Environmental Engineering"
            }
        ],
        "title": "Research on affecting of pH in nitrogen-phosphorus removal and recovery from human urine with MAP crystallization",
        "abstract": "Fresh urine used to be handling object in this experiment, the effect that pH for the recovery and removal nitrogen and phosphorus of urine and reaction process was researched in MAP sedimentation process after pretreatment. Adopting MgCl",
        "keywords": [
            "Ammonia nitrogen ammonium phosphate",
            "Magnesium ammonium phosphate crystallization",
            "pH"
        ],
        "venue": "Shenyang Jianzhu Daxue Xuebao (Ziran Kexue Ban)/Journal of Shenyang Jianzhu University (Natural Science)",
        "year": 2012,
        "id": "yRcQNZaK"
    },
    "PIqMUsky": {
        "authors": [
            {
                "name": "Jinxiang Fu",
                "org": "Shenyang Ecological Environment Research Institute"
            },
            {
                "name": "Lu Zhao",
                "org": "School of Municipal and Environmental Engineering"
            },
            {
                "name": "Fuqiang Chi",
                "org": "School of Municipal and Environmental Engineering"
            },
            {
                "name": "Zhi Wang",
                "org": "School of Municipal and Environmental Engineering"
            },
            {
                "name": "Haibiao Wang",
                "org": "School of Municipal and Environmental Engineering"
            }
        ],
        "title": "Research on the affecting factors of denitrifying phosphorus removal with nitrite",
        "abstract": "This paper is to study the operation parameter and affecting factors in the process of denitrifying phosphorus removal with nitrite as electronic receptor. Under the anaerobic/anoxic condition, with SBR, the static contrast test of denitrifying phosphorus removal with nitrite as electronic receptor is carried out, finding out the optimum operating condition through changing the temperature, carbon fountain, concentration of electronic receptor, age of mud and so on. The experiment shows that, in the process of denitrifying phosphorus removal, NaCH\n                        ",
        "keywords": [
            "Affecting factors",
            "Denitrifying phosphorus removal",
            "Electronic receptor",
            "Nitrite"
        ],
        "venue": "Shenyang Jianzhu Daxue Xuebao (Ziran Kexue Ban)/Journal of Shenyang Jianzhu University (Natural Science)",
        "year": 2009,
        "id": "PIqMUsky"
    },
    "yZG95qIm": {
        "id": "yZG95qIm",
        "title": "Blind Forensic of JPEG Forgeries Based on Local Blocking Artifacts",
        "abstract": "The blocking artifact in the JPEG images is becoming a more and more important clue in detecting image forgeries. This paper presents a new block artifact measure of the images local area and an effective method of blind forensic of JPEG forgeries on the basis of analyzing the overall block artifact of the JPEG images.Firstly,we calculate the horizontal and vertical differences maps of the JPEG image,and then divide the two maps into many sub-blocks with a specific size.Secondly,we measure the block artifact of each sub-block on the local area using the new method.Finally,respectively from the horizontal and vertical direction,the detection and location of doctored region is realized via checking significant differences of block artifact in different local areas.The experimental results validate the proposed approach in blind detecting the tampered area of the double JPEG compressed images.The slider blocks of varied sizes and different evaluation formulas are further used to detect the image forgeries.At the end of the paper,we give the pros and cons of different algorithms on the analysis of counter-interference and algorithm efficiency,which lays the foundation for further research in the area of JPEG forgeries blind forensic.",
        "keywords": [
            "block artifact",
            "blind forensic",
            "double JPEG compression",
            "image forgery"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "Science & Technology Division of Guilin Electronic Science and Technology,Guilin  China"
            },
            {
                "name": "LIU Xiao-teng",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing  China"
            },
            {
                "name": "JING Tao",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing  China"
            },
            {
                "name": "LI Xing-hua",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing  China"
            },
            {
                "name": "HUO Yan",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing  China;Electronic Engineering of Shanghai Jiaotong University,Shanghai  China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2010
    },
    "9O6iIyTR": {
        "id": "9O6iIyTR",
        "title": "Blind Detection of Digital Forgeries Using Detection Trace of Eclosion",
        "abstract": "A novel method is presented for blinding detection of digital forgeries based on employing the eclosion when someone forges the digital image.The basic idea of the presented method in this article is that analyzing the texture of the image.In other words, at the first place,we decompose the image and then reconstruct the profile.In order to remove a small amount of noise in the texture image, we employ the dual tree complex wavelet transform,and then reconstruct the profile.The experimental results show that the algorithm can locate the edge eclosion exactly without any embedded information such as digital watermark and digital signature.",
        "keywords": [
            "edge eclosion",
            "dual tree complex wavelet transform",
            "soft threshold",
            "image decomposition"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "Science & Technology Division of Guilin Electronic Science and Technology"
            },
            {
                "name": "LI Xing-hua",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing "
            },
            {
                "name": "PENG Yue-feng",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing "
            },
            {
                "name": "HUO Yan",
                "org": "School of Electronics and Information Engineering,Beijing Jiaotong University,Beijing ;Electronic Engineering of Shanghai Jiaotong University"
            }
        ],
        "venue": "Signal Processing",
        "year": 2009
    },
    "1AS6oZZA": {
        "id": "1AS6oZZA",
        "title": "An Update on Hydrogen Sulfide and Nitric Oxide Interactions in the Cardiovascular System",
        "abstract": "Hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as important regulators in the cardiovascular system, although they were historically considered as toxic gases. As gaseous transmitters, H2S and NO share a wide range of physical properties and physiological functions: they penetrate into the membrane freely; they are endogenously produced by special enzymes, they stimulate endothelial cell angiogenesis, they regulate vascular tone, they protect against heart injury, and they regulate target protein activity via posttranslational modification. Growing evidence has determined that these two gases are not independent regulators but have substantial overlapping pathophysiological functions and signaling transduction pathways. H2S and NO not only affect each other\u2019s biosynthesis but also produce novel species through chemical interaction. They play a regulatory role in the cardiovascular system involving similar signaling mechanisms or molecular targets. However, the natural precise mechanism of the interactions between H2S and NO remains unclear. In this review, we discuss the current understanding of individual and interactive regulatory functions of H2S and NO in biosynthesis, angiogenesis, vascular one, cardioprotection, and posttranslational modification, indicating the importance of their cross-talk in the cardiovascular system.",
        "keywords": "",
        "authors": [
            {
                "name": "Dan Wu",
                "org": "Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China"
            },
            {
                "name": "Qingxun Hu",
                "org": "Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, USA"
            },
            {
                "name": "Deqiu Zhu",
                "org": "Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China"
            }
        ],
        "venue": "Oxidative Medicine and Cellular Longevity",
        "year": 2018
    },
    "8daVeLWi": {
        "id": "8daVeLWi",
        "title": "Novel HS-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure.",
        "abstract": "Therapeutic strategies that increase hydrogen sulfide (HS) or nitric oxide (NO) are cytoprotective in various models of cardiovascular injury. However, the nature of interaction between HS and NO in heart failure and the underlying mechanisms for the protective effects remain undefined. The present study tested the cardioprotective effect of ZYZ-803, a novel synthetic HS-NO hybrid molecule that decomposed to release HS and NO. ZYZ-803 dose dependently improved left ventricular remodeling and preserved left ventricular function in the setting of isoprenaline-induced heart failure. The cardioprotective effect of ZYZ-803 is significantly more potent than that of HS and/or NO donor alone. ZYZ-803 stimulated the expression of cystathionine \u03b3-lyase (CSE) for HS generation and the activity of endothelial NO synthase (eNOS) for NO production. Blocking CSE and/or eNOS suppressed ZYZ-803-induced HS and NO production and cardioprotection. ZYZ-803 increased vascular endothelial growth factor (VEGF) concentration and cyclic guanosine 5'-monophosphate (cGMP) level. Moreover, ZYZ-803 upregulated the endogenous antioxidants, glutathione peroxidase (GPx) and heme oxygenase 1 (HO-1). These findings indicate that HS and NO cooperatively attenuates left ventricular remodeling and dysfunction during the development of heart failure through VEGF/cGMP pathway and ZYZ-803 provide expanding insight into strategies for treatment of heart failure.",
        "keywords": [
            "Heart failure",
            "Hydrogen sulfide",
            "Nitric oxide"
        ],
        "authors": [
            {
                "name": "Dan Wu",
                "org": "Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China; School of Pharmacy, Macau University of Science and Technology, Macau, China."
            },
            {
                "name": "Qingxun Hu",
                "org": "Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China; Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, USA."
            },
            {
                "name": "Ying Xiong",
                "org": "Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China."
            },
            {
                "name": "Deqiu Zhu",
                "org": "Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China."
            },
            {
                "name": "Yicheng Mao",
                "org": "Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China. Electronic address: maoyc@fudan.edu.cn."
            },
            {
                "name": "Yi Zhun Zhu",
                "org": "School of Pharmacy, Macau University of Science and Technology, Macau, China. Electronic address: yzzhu@must.edu.mo."
            }
        ],
        "venue": "Redox biology",
        "year": 2017
    },
    "FZ7lQy0z": {
        "id": "FZ7lQy0z",
        "title": "Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca/calmodulin-dependent protein kinase II.",
        "abstract": "A novel mechanism depicting a role of S-sulfhydration in the regulation of CaMKII is presented. SPRC mediated S-sulfhydration of CaMKII was found to inhibit CAMKII activity and to preserve cardiovascular homeostasis.",
        "keywords": [
            "Ca(2+)/calmodulin-dependent protein kinase II",
            "Heart Failure",
            "Hydrogen Sulfide",
            "Mitochondria",
            "S-sulfhydration"
        ],
        "authors": [
            {
                "name": "Dan Wu",
                "org": "Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China."
            },
            {
                "name": "Qingxun Hu",
                "org": "Mitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, USA."
            },
            {
                "name": "Bo Tan",
                "org": "School of Pharmacy, Fudan University, Shanghai, China."
            },
            {
                "name": "Peter Rose",
                "org": "School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom."
            },
            {
                "name": "Deqiu Zhu",
                "org": "Department of Pharmacy, Tongji Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address: zdq_0726@163.com."
            },
            {
                "name": "Yi Zhun Zhu",
                "org": "School of Pharmacy, Macau University of Science and Technology, Macau, China; School of Pharmacy, Fudan University, Shanghai, China. Electronic address: yzzhu@must.edu.mo."
            }
        ],
        "venue": "Redox biology",
        "year": 2018
    },
    "5oYUBKdo": {
        "id": "5oYUBKdo",
        "title": "The Shipbuilding Supply Chain Coordination of Cooperation Schedule",
        "abstract": "The shipbuilding supply chain is the system required coordination.The cooperation schedule is a key part of the supply chain coordination.The shippuilding supply chain coordination of cooperation schedule directly helps reduce the shipbuilding stock,cost and cycle,enhance shipbuilding efficiency and competitive ability.In order to guarantee the effective implementation of the shipbuilding supply chain coordination of cooperation schedule,we should introduce cooperation culture,information sharing,business process reorganization,innovation of production plan,JIT purchase system and cooperation coordination mechanism.",
        "keywords": [
            "shipbuilding supply chain",
            "coordination",
            "cooperation"
        ],
        "authors": [
            {
                "name": "ZHANG Guangming",
                "org": "School of Economics and Management,Jiangsu University of Science and Technology,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "WANG Yaping",
                "org": "School of Economics and Management,Jiangsu University of Science and Technology,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "WANG Hui",
                "org": "School of Economics and Management,Jiangsu University of Science and Technology,Zhenjiang Jiangsu ,China"
            },
            {
                "name": "XIE Pingshun",
                "org": "School of Economics and Management,Jiangsu University of Science and Technology,Zhenjiang Jiangsu ,China"
            }
        ],
        "venue": "Journal of Jiangsu University of Science and Technology(Social Science Edition)",
        "year": 2006
    },
    "bcYpLNDF": {
        "id": "bcYpLNDF",
        "title": "Comparative Study of Supply Chain with Industrial Cluster",
        "abstract": "Supply chain and industrial cluster are the results of competition economy. The distinguish and relation of them were discussed in order to put forward that supply chain and industrial cluster could be introjected and that two paths to realize This is the theory base for application of the supply chain management methods in the industrial cluster construction and obtaining the competition advantage of industrial cluster based on global supply chains.",
        "keywords": [
            "supply chain",
            "introjections",
            "industrial cluster"
        ],
        "authors": [
            {
                "name": "Wang Hui",
                "org": "School of Economics,Jiangsu University of Sciences and Technology,Zhenjiang ,China"
            },
            {
                "name": "Zhang Guangming",
                "org": "School of Economics,Jiangsu University of Sciences and Technology,Zhenjiang ,China"
            },
            {
                "name": "Wang Yaping",
                "org": "School of Economics,Jiangsu University of Sciences and Technology,Zhenjiang ,China"
            }
        ],
        "venue": "Value Engineering",
        "year": 2006
    },
    "RvWHBdT7": {
        "id": "RvWHBdT7",
        "title": "Building of Manufacture SCM Information Platform Based on J2EE",
        "abstract": "In the paper,according to the framework and the function requirement of SCM,the critical technology and its connotation of building SCM information interactive platform are addressed.The specific function modules of SCM information platform are addressed detailed.The idea for designing SCM information interactive platform and the method of building based on J2EE are described.The platform solves the problems of traditional SC MIS(management information system),such as low agility,weak rebuilding and so on.",
        "keywords": [
            "platform",
            "EJB",
            "supply-chain",
            "J2EE"
        ],
        "authors": [
            {
                "name": "XIE Ping-shun",
                "org": "Jiangsu University of Science and Technology,Zhenjiang ,China"
            },
            {
                "name": "ZHANG Guang-ming",
                "org": "Jiangsu University of Science and Technology,Zhenjiang ,China"
            },
            {
                "name": "WANG Hui",
                "org": "Jiangsu University of Science and Technology,Zhenjiang ,China"
            },
            {
                "name": "WANG Ya-ping",
                "org": "Jiangsu University of Science and Technology,Zhenjiang ,China"
            }
        ],
        "venue": "Group Technology & Production Modernization",
        "year": 2006
    },
    "9IBnxGOz": {
        "id": "9IBnxGOz",
        "title": "Experimental test of the trade-off relation for quantum coherence",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Wei-Min Lv",
                "org": ""
            },
            {
                "name": "Chao Zhang",
                "org": ""
            },
            {
                "name": "Xiao-Min Hu",
                "org": ""
            },
            {
                "name": "Huan Cao",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Yun-Feng Huang",
                "org": ""
            },
            {
                "name": "Bi-Heng Liu",
                "org": ""
            },
            {
                "name": "Chuan-Feng Li",
                "org": ""
            },
            {
                "name": "Guang-Can Guo",
                "org": ""
            }
        ],
        "venue": "Physical Review A",
        "year": 2018
    },
    "Jph3aozB": {
        "id": "Jph3aozB",
        "title": "A photonic quantum interface for hybrid quantum network",
        "abstract": "The hybrid quantum network, a universal form of quantum network which is aimed for quantum communication and distributed quantum computation, is that the quantum nodes in it are realized with different physical systems. This universal form of quantum network can combine the advantages and avoid the inherent defects of the different physical system. However, one obstacle standing in the way is the compatible photonic quantum interface. One possible solution is using non-degenerate, narrow-band, entangled photon pairs as the photonic interface. Here, for the first time, we generate nondegenrate narrow-band polarization-entangled photon pairs in cavity-enhanced spontaneous parametric down-conversion process. The bandwidths and central wavelengths of the signal and idler photons are 9 MHz at 935 nm and 9.5 MHz at 880 nm, which are compatible with trapped ion system and solid-state quantum memory system. The entanglement of the photon source is certified by quantum state tomography, showing a fidelity of 89.6% between the generated quantum state with a Bell state. Besides, a strong violation against Bell inequality with 2.36+/-0.03 further confirms the entanglement property of the photon pairs. Our method is suitable for the hybrid quantum network and will take a big step in this field.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Yun-Feng Huang",
                "org": ""
            },
            {
                "name": "Chao Zhang",
                "org": ""
            },
            {
                "name": "Jin-Ming Cui",
                "org": ""
            },
            {
                "name": "Zong-Quan Zhou",
                "org": ""
            },
            {
                "name": "Zhi-Yuan Zhou",
                "org": ""
            },
            {
                "name": "Jian-Shun Tang",
                "org": ""
            },
            {
                "name": "Bi-Heng Liu",
                "org": ""
            },
            {
                "name": "Chuan-Feng Li",
                "org": ""
            },
            {
                "name": "Guang-Can Guo",
                "org": ""
            }
        ],
        "venue": "arXiv: Quantum Physics",
        "year": 2017
    },
    "KgelLKpv": {
        "id": "KgelLKpv",
        "title": "Experimental Trapped-ion Quantum Simulation of the Kibble-Zurek dynamics in momentum space",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Jin-Ming Cui",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Yun-Feng Huang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Zhao Wang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Dong-Yang Cao",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Jian Wang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Wei-Min Lv",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Yong-Jian Han",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Chuan-Feng Li",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Guang-Can Guo",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Jin-Ming Cui",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Yun-Feng Huang",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Zhao Wang",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Dong-Yang Cao",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Jian Wang",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Wei-Min Lv",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Yong-Jian Han",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Chuan-Feng Li",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Guang-Can Guo",
                "org": "Synergetic Innovation Center of Quantum Information and Quantum Physics,University of Science and Technology of China, Hefei, 230026, People\u2019s Republic of China"
            },
            {
                "name": "Le Luo",
                "org": "Trapped Atoms and Ions Laboratory, Department of Physics,Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202-3273, USA"
            },
            {
                "name": "Adolfo del Campo",
                "org": "Department of Physics, University of Massachusetts Boston,100 Morrissey Boulevard, Boston, MA 02125, USA"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "wRpsmYLl": {
        "id": "wRpsmYLl",
        "title": "Experimental Demonstration of Higher Precision Weak-Value-Based Metrology Using Power Recycling.",
        "abstract": "The weak-value-based metrology is very promising and has attracted a lot of attention in recent years because of its remarkable ability in signal amplification. However, it is suggested that the upper limit of the precision of this metrology cannot exceed that of classical metrology because of the low sample size caused by the probe loss during postselection. Nevertheless, a recent proposal shows that this probe loss can be reduced by the power-recycling technique, and thus enhance the precision of weak-value-based metrology. Here we experimentally realize the power-recycled interferometric weak-value-based beam-deflection measurement and obtain the amplitude of the detected signal and white noise by discrete Fourier transform. Our results show that the detected signal can be strengthened by power recycling, and the power-recycled weak-value-based signal-to-noise ratio can surpass the upper limit of the classical scheme, corresponding to the shot-noise limit. This work sheds light on higher precision metrology and explores the real advantage of the weak-value-based metrology over classical metrology.",
        "keywords": "",
        "authors": [
            {
                "name": "Yi-Tao Wang",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Jian-Shun Tang",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Gang Hu",
                "org": "Department of Physics, Central China Normal University, Wuhan 430079, People's Republic of China."
            },
            {
                "name": "Jian Wang",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Shang Yu",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Zong-Quan Zhou",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Ze-Di Cheng",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Jin-Shi Xu",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Sen-Zhi Fang",
                "org": "Department of Physics, Central China Normal University, Wuhan 430079, People's Republic of China."
            },
            {
                "name": "Qing-Lin Wu",
                "org": "Department of Physics, Central China Normal University, Wuhan 430079, People's Republic of China."
            },
            {
                "name": "Chuan-Feng Li",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            },
            {
                "name": "Guang-Can Guo",
                "org": "Synergetic Innovation Center of Quantum Information Quantum Physics, University of Science and Technology of China, Hefei 230026, People's Republic of China."
            }
        ],
        "venue": "Physical review letters",
        "year": 2016
    },
    "ctsR3fpK": {
        "id": "ctsR3fpK",
        "title": "Generation and applications of an ultrahigh-fidelity four-photon Greenberger-Horne-Zeilinger state.",
        "abstract": "High-quality entangled photon pairs generated via spontaneous parametric down-conversion have made great contributions to the modern quantum information science and the fundamental tests of quantum mechanics. However, the quality of the entangled states decreases sharply when moving from biphoton to multiphoton experiments, mainly due to the lack of interactions between photons. Here, for the first time, we generate a four-photon Greenberger-Horne-Zeilinger state with a fidelity of 98%, which is even comparable to the best fidelity of biphoton entangled states. Thus, it enables us to demonstrate an ultrahigh-fidelity entanglement swapping-the key ingredient in various quantum information tasks. Our results push the fidelity of multiphoton entanglement generation to a new level and would be useful in some demanding tasks, e.g., we successfully demonstrate the genuine multipartite nonlocality of the observed state in the nonsignaling scenario by violating a novel Hardy-like inequality, which requires very high state-fidelity.",
        "keywords": "",
        "authors": [
            {
                "name": "Chao Zhang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei 230026, China"
            },
            {
                "name": "Yun-Feng Huang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei 230026, China"
            },
            {
                "name": "Cheng-Jie Zhang",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei 230026, China"
            },
            {
                "name": "Bi-Heng Liu",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei 230026, China"
            },
            {
                "name": "Chuan-Feng Li",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei 230026, China"
            },
            {
                "name": "Guang-Can Guo",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, CAS, Hefei 230026, China"
            }
        ],
        "venue": "Optics express",
        "year": 2016
    },
    "3SvuMDpr": {
        "id": "3SvuMDpr",
        "title": "Experimental test of fine-grained entropic uncertainty relation in the presence of quantum memory.",
        "abstract": "The uncertainty principle, which gives the constraints on obtaining precise outcomes for incompatible measurements, provides a new vision of the real world that we are not able to realize from the classical knowledge. In recent years, numerous theoretical and experimental developments about the new forms of the uncertainty principle have been achieved. Among these efforts, one attractive goal is to find tighter bounds of the uncertainty relation. Here, using an all optical setup, we experimentally investigate a most recently proposed form of uncertainty principle-the fine-grained uncertainty relation assisted by a quantum memory. The experimental results on the case of two-qubit state with maximally mixed marginal demonstrate that the fine-graining method can help to get a tighter bound of the uncertainty relation. Our results might contribute to further understanding and utilizing of the uncertainty principle.",
        "keywords": "",
        "authors": [
            {
                "name": "Wei-Min Lv",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            },
            {
                "name": "Chao Zhang",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China. zhc1989@ustc.edu.cn."
            },
            {
                "name": "Xiao-Min Hu",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            },
            {
                "name": "Yun-Feng Huang",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China. hyf@ustc.edu.cn."
            },
            {
                "name": "Huan Cao",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            },
            {
                "name": "Jian Wang",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            },
            {
                "name": "Zhi-Bo Hou",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            },
            {
                "name": "Bi-Heng Liu",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            },
            {
                "name": "Chuan-Feng Li",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China. cfli@ustc.edu.cn."
            },
            {
                "name": "Guang-Can Guo",
                "org": "CAS Center For Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, 230026, People's Republic of China."
            }
        ],
        "venue": "Scientific reports",
        "year": 2019
    },
    "MnsTAlYV": {
        "id": "MnsTAlYV",
        "title": "Degenerate cavity supporting more than 31 Laguerre-Gaussian modes.",
        "abstract": "Photons propagating in Laguerre-Gaussian modes have characteristic orbital angular momenta, which are fundamental optical degrees of freedom. The orbital angular momentum of light has potential application in high-capacity optical communication and even in quantum information processing. In this work, we experimentally construct a ring cavity with four lenses and four mirrors that is completely degenerate for Laguerre-Gaussian modes. By measuring the transmitted peaks and patterns of different modes, the ring cavity is shown to support more than 31 Laguerre-Gaussian modes. The constructed degenerate cavity opens a new way for using the unlimited resource of available angular momentum states simultaneously.",
        "keywords": "",
        "authors": [
            {
                "name": "Ze-Di Cheng",
                "org": ""
            },
            {
                "name": "Zhao-Di Liu",
                "org": ""
            },
            {
                "name": "Xi-Wang Luo",
                "org": ""
            },
            {
                "name": "Zheng-Wei Zhou",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Qiang Li",
                "org": ""
            },
            {
                "name": "Yi-Tao Wang",
                "org": ""
            },
            {
                "name": "Jian-Shun Tang",
                "org": ""
            },
            {
                "name": "Jin-Shi Xu",
                "org": ""
            },
            {
                "name": "Chuan-Feng Li",
                "org": ""
            },
            {
                "name": "Guang-Can Guo",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2017
    },
    "j5gXn0zz": {
        "id": "j5gXn0zz",
        "title": "Generation of nondegenerate narrow-band photon pairs for hybrid quantum network",
        "abstract": "In a hybrid quantum network, linking two kinds of quantum nodes through photonic channels requires excellent matching of central frequency and bandwidth between both nodes and their interfacing photons. However, pre-existing photon sources can not fulfill this requirement. Using a novel conjoined double-cavity strategy, we report the generation of nondegenerate narrow-band photon pairs by cavity-enhanced spontaneous parametric down-conversion. The central frequencies and bandwidths of the signal and idler photons are independently set to match with trapped ions and solid-state quantum memories. With this source we achieve the bandwidths and central frequencies of 4 MHz at 935 nm and 5 MHz at 880 nm for the signal and idler photons respectively, with a normalized spectrum brightness of 4.9/s/MHz/mW. Due to the ability of being independently locked to two different wavelenghts, the conjoined double-cavity is universally suitable for hybrid quantum network consisting of various quantum nodes.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Wang",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Peng-YinJie Lv",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Jin-Ming Cui",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Bi-Heng Liu",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Jian-Shun Tang",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Yun-Feng Huang",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Chuan-Feng Li",
                "org": "University of Science and Technology of China"
            },
            {
                "name": "Guang-Can Guo",
                "org": "University of Science and Technology of China"
            }
        ],
        "venue": "Bulletin of the American Physical Society",
        "year": 2016
    },
    "MpzR6nux": {
        "id": "MpzR6nux",
        "title": "Universal Photonic Quantum Interface for a Quantum Network",
        "abstract": "A quantum network consisting of more than one physical system can combine the advantages and avoid the inherent drawbacks of those different systems. However, a compatible quantum interface is needed to connect them and form a larger quantum network. The authors use nondegenerate narrow-band polarization-entangled photon pairs to entangle different nodes, creating a universal photonic quantum interface that will significantly aid in the development of more complex networks, for quantum communication or distributed quantum computing.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Wang",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Yun-Feng Huang",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Chao Zhang",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Jin-Ming Cui",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Zhi-Yuan Zhou",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Bi-Heng Liu",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Zong-Quan Zhou",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Jian-Shun Tang",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Chuan-Feng Li",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            },
            {
                "name": "Guang-Can Guo",
                "org": "CAS Key Laboratory of Quantum Information, University of Science and Technology of China, Hefei 230026, P.R. China"
            }
        ],
        "venue": "Physical review applied",
        "year": 2018
    },
    "RxGqMw2f": {
        "id": "RxGqMw2f",
        "title": "An Ultraviolet Fiber Fabry\u2013P\u00e9rot Cavity for Florescence Collection of Trapped Ions",
        "abstract": "We demonstrate a fiber Fabry\u2013Perot cavity in the ultraviolet range, which covers the florescence wavelength for the 2P1/2 to 2S1/2 transition of Yb+ and is designed in the bad cavity limit for florescence collection. Benefiting from both the small cavity mode volume and the large atom dipole, a cavity with moderate finesse and high transmission still supports a good cooperativity, which is made and tested in experiment. Based on the measured experimental parameters, simulation performed on the cavity and ion shows a Purcell factor better than 2.5 and a single-mode fiber collection efficiency over 10%. This technology can support ultra-bright single photon sources based on trapped ions and can provide the possibility to link remote atoms as a quantum network.",
        "keywords": "",
        "authors": [
            {
                "name": "Kun Zhou",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Jin-Ming Cui",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Yun-Feng Huang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Zhao Wang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Zhong-Hua Qian",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Qi-Ming Wu",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Jian Wang",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Ran He",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Wei-Min Lv",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Chang-Kang Hu",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Yong-Jian Han",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Chuan-Feng Li",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            },
            {
                "name": "Guang-Can Guo",
                "org": "Key Laboratory of Quantum Information, University of Science and Technology of China, Chinese Academy of Sciences, Hefei 230026"
            }
        ],
        "venue": "Chinese Physics Letters",
        "year": 2017
    },
    "HFDTwKJV": {
        "id": "HFDTwKJV",
        "title": "Assembling of stimuli-responsive tumor targeting polypyrrole nanotubes drug carrier system for controlled release.",
        "abstract": "A stimuli-responsive polypyrrole (PPy) nanotubes drug carrier system has been designed to deliver anticancer drugs to tumor cells in a targeted and controlled manner. The PPy nanotubes drug carrier was fabricated by a template method. The nanotubes surface was functionalized with cleavable acylhydrazone and disulfide bonds by attaching thiolated \u03b2-cyclodextrin (\u03b2-CD). The solubilizing poly(ethylene glycol) polymer (PEG), attached with an adamantane (Ad) entity at one end and a folate (FA) entity at the other end, was introduced onto the nanotubes surface via \u03b2-cyclodextrin-adamantane interaction. The synthesized FA-PEG-Ad-\u03b2-CD-PPy showed excellent biocompatibility and low cytotoxicity for two cell lines. Doxorubicin (Dox) loaded FA-PEG-Ad-\u03b2-CD-PPy nanotubes showed a triggered in vitro drug release behavior in the presence of acidic media and reducing agents. The folate-mediated endocytosis and intracellular release of Dox-loaded nanoparticles were confirmed by fluorescence microscopy and cell viability evaluations. In the in vitro study, Dox loaded within the nanoparticles showed enhanced selectivity for cancerous cells and reduced cytotoxicity for normal cells compared to free Dox. The PPy based targeted drug vehicle shows excellent promise for drug delivery.",
        "keywords": [
            "Folate",
            "Polypyrrole nanotube",
            "Stimuli-responsive",
            "Targeting"
        ],
        "authors": [
            {
                "name": "Jian Chen",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Xiufang Li",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Jiawen Li",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Jianbing Li",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Ling Huang",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Tao Ren",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Xiao Yang",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China."
            },
            {
                "name": "Shian Zhong",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, PR China. Electronic address: zhongshian@aliyun.com."
            }
        ],
        "venue": "Materials science & engineering. C, Materials for biological applications",
        "year": 2018
    },
    "5pAvfkYG": {
        "id": "5pAvfkYG",
        "title": "Synthesis of Size-Tunable Hollow Polypyrrole Nanostructures and Their Assembly into Folate-Targeting and pH-Responsive Anticancer Drug-Delivery Agents.",
        "abstract": "Chemotherapeutic drugs currently used in clinical settings have high toxicity, low specificity, and short half-lives. Herein, polypyrrole-based anticancer drug nanocapsules were prepared by tailoring the size of the nanoparticles with a template method, controlling drug release by means of an aromatic imine, increasing nanoparticle stability through PEGylation, and improving tumor-cell selectivity by folate mediation. The nanoparticles were characterized by TEM and dynamic light scattering. \u03b1-Folate receptor expression levelsof tumor cells and normal cells were investigated by western blot and quantitative polymerase chain reaction analyses. Flow cytometry and fluorescence imaging were used to verify the cell uptake of the different-sized nanoparticles. From the different-sized polypyrrole nanoparticles, the optimally functionalized nanoparticles of 180\u2005nm hydrodynamic diameter were chosen and further usedfor in\u2005vitroandin\u2005vivotests. The nanoparticles showed excellent biocompatibility and the drug-loaded nanoparticles exhibited effective inhibition of tumor cell growth in\u2005vitro. Moreover, the drug-loaded nanoparticles showed substantially enhanced accumulation in tumor regions and effectively inhibitedin\u2005vivotumor growth. Furthermore, the nanoparticles showed reduced doxorubicin-induced toxicity andno significant side effects in normal organs of tumor-bearing mice, as measured by body-weight shifts and evaluationof drug distribution. Overall, the functionalized nanoparticles are promising nanocarriers for tumor-targeting drug delivery.",
        "keywords": [
            "cancer",
            "drug delivery",
            "nanotubes",
            "polymers",
            "template synthesis"
        ],
        "authors": [
            {
                "name": "Jian Chen",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            },
            {
                "name": "Xiufang Li",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            },
            {
                "name": "Yanhua Sun",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            },
            {
                "name": "Yuwei Hu",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            },
            {
                "name": "Yulong Peng",
                "org": "School of Basic Medical Science, Central South University, Changsha, Hunan, 410083, P.R. China."
            },
            {
                "name": "Yimin Li",
                "org": "School of Basic Medical Science, Central South University, Changsha, Hunan, 410083, P.R. China."
            },
            {
                "name": "Gang Yin",
                "org": "School of Basic Medical Science, Central South University, Changsha, Hunan, 410083, P.R. China."
            },
            {
                "name": "Hui Liu",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            },
            {
                "name": "Jiangfeng Xu",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            },
            {
                "name": "Shian Zhong",
                "org": "College of Chemistry and Chemical Engineering, Central South University, Changsha Hunan, 410083, P.R. China."
            }
        ],
        "venue": "Chemistry (Weinheim an der Bergstrasse, Germany)",
        "year": 2017
    },
    "zrUmDMuj": {
        "id": "zrUmDMuj",
        "title": "Multifunctional halloysite nanotubes for targeted delivery and controlled release of doxorubicin in-vitro and in-vivo studies.",
        "abstract": "Abstract The current state of cancer therapy encourages researchers to develop novel efficient nanocarriers. Halloysite nanotubes (HNTs) are good nanocarrier candidates due to their unique nanoscale (40-80 nm in diamter and 200-500 nm in length) and hollow lumen, as well as good biocompatibility and low cost. In our study, we prepared a type of folate-mediated targeting and redox-triggered anticancer drug delivery system, so that Doxorubicin (DOX) can be specifically transported to tumor sites due to the over-expressed folate-receptors on the surface of cancer cells. Furthermore, it can then be released by the reductive agent glutathione (GSH) in cancer cells where the content of GSH is nearly 10(3)-fold higher than in the extracellular matrix. A series of methods have demonstrated that per-thiol-\u03b2-cyclodextrin (\u03b2-CD-(SH)7) was successfully combined with HNTs via a redox-responsive disulfide bond, and folic acid-polyethylene glycol-adamantane (FA-PEG-Ad) was immobilized on the HNTs through the strong complexation between \u03b2-CD/Ad. In vitro studies indicated that the release rate of DOX raised sharply in dithiothreitol (DTT) reducing environment and the amount of released DOX reached 70% in 10 mM DTT within the first 10 h, while only 40% of DOX was released in phosphate buffer solution (PBS) even after 79 h. Furthermore, the targeted HNTs could be specifically endocytosed by over-expressed folate-receptor cancer cells and significantly accelerate the apoptosis of cancer cells compared to non-targeted HNTs. In vivo studies further verified that the targeted HNTs had the best therapeutic efficacy and no obvious side effects for tumor-bearing nude mice, while free DOX showed damaging effects on normal tissues. In summary, this novel nanocarrier system shows excellent potential for targeted delivery and controlled release of anticancer drugs and provides a potential platform for tumor therapy.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuwei Hu",
                "org": ""
            },
            {
                "name": "Jian Chen",
                "org": ""
            },
            {
                "name": "Xiufang Li",
                "org": ""
            },
            {
                "name": "Yanhua Sun",
                "org": ""
            },
            {
                "name": "Shen Huang",
                "org": ""
            },
            {
                "name": "Yuqing Li",
                "org": ""
            },
            {
                "name": "Hui Liu",
                "org": ""
            },
            {
                "name": "Jiangfeng Xu",
                "org": ""
            },
            {
                "name": "Shian Zhong",
                "org": ""
            }
        ],
        "venue": "Nanotechnology",
        "year": 2017
    },
    "ju03HkcD": {
        "id": "ju03HkcD",
        "title": "Bio-inspired magnetic molecularly imprinted polymers based on Pickering emulsions for selective protein recognition",
        "abstract": "Novel magnetic molecularly imprinted polymers (MMIPs) based on halloysite nanotube stabilized Pickering emulsion polymerization were successfully prepared using a facile approach for the high recognition and separation of proteins in aqueous solutions. The MMIPs were synthesized based on the self-polymerization of dopamine in weak alkaline solution in the presence of template protein. During the self-polymerization of dopamine in the water phase, the template proteins were embedded in polydopamine (PDA), and after the removal of the embedded template proteins, magnetic bovine hemoglobin (BHb) imprinted PDA@MHNTs (MHNTs, magnetic halloysite nanotubes) with complementary cavities were eventually obtained. The resulting samples were analyzed by Fourier transmission infrared (FT-IR) spectrometry, scanning electron microscopy (SEM), vibrating sample magnetometry (VSM) and thermogravimetric analysis (TGA). The prepared MMIPs showed high adsorption capacity, good selectivity, rapid kinetic binding (70 min), stability (only 9% decrease after four cycles) and magnetic separability (3 min), which would endow the MMIPs with great potential in the field of protein separation and purification, biosensing, proteomics and biotherapy.",
        "keywords": "",
        "authors": [
            {
                "name": "Yanhua Sun",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Jian Chen",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Yuqing Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Hui Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Xiaohong Zhu",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Yuwei Hu",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Shen Huang",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Jianbing Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Shian Zhong",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            }
        ],
        "venue": "New Journal of Chemistry",
        "year": 2016
    },
    "k7IoXR7x": {
        "id": "k7IoXR7x",
        "title": "Novel application of amphiphilic block copolymers in Pickering emulsions and selective recognition of proteins",
        "abstract": "Pickering high internal phase emulsions (HIPEs) stabilized by the amphiphilic block copolymer polystyrene\u2013polymethacrylic acid (PS\u2013PMAA) were prepared, and porous materials with specific imprinting sites for the template protein were fabricated after the polymerization of dopamine in the water phase. To the best of our knowledge, PS\u2013PMAA was used for the first time in Pickering emulsion polymerization and removed for the purpose of improving the mass-transfer efficiency. SEM was employed to observe the porous structure. Additionally, FT-IR spectroscopy proved that PS\u2013PMAA was completely removed from the imprinted porous materials. The results indicated that the polydopamine imprinted materials (PDA-MIPs) exhibited an excellent recognition capacity. A high maximum absorption capacity of 472 mg g\u22121 was obtained, which was 3.07 times higher than that of the non-imprinted polymers (PDA-NIPs). Selective analysis indicated that PDA-MIPs showed a higher selectivity to the template protein when compared to control proteins. The regeneration measurement revealed that the PDA-MIPs could be recycled and remained stable during their reuse.",
        "keywords": "",
        "authors": [
            {
                "name": "Jiangfeng Xu",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha,China"
            },
            {
                "name": "Yanhua Sun",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha,China"
            },
            {
                "name": "Jian Chen",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha,China"
            },
            {
                "name": "Shian Zhong",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha,China"
            }
        ],
        "venue": "New Journal of Chemistry",
        "year": 2018
    },
    "tpEgdZHg": {
        "id": "tpEgdZHg",
        "title": "An effective and convenient synthesis of cordycepin from adenosine",
        "abstract": "Cordycepin is a purine nucleoside analog with potent and diverse biological activities. Herein, we designed two methods to synthesize cordycepin. One method mainly converted the 3\u2032-OH group into an iodide group and further dehalogenation to yield the final product. Although this method presented a short synthetic procedure, the synthesis had a low overall yield, resulting in only 13.5% overall yield. To improve the overall yield of cordycepin, another synthetic route was studied, which consisted of four individual steps: (1) 5\u2032-OH protection (2) esterification (3) -O-tosyl (-OTs) group removal (4) deprotection. The key step in the synthetic method involved the conversion of 5\u2032-O-triphenylmethyladenosine to 3\u2032-O-tosyl-5\u2032-O-triphenylmethyladenosine, using LiAlH4 as reducing agent. The main advantages of this route were an acceptable total product yield and the commercial availability of all starting materials. The optimal reaction conditions for each step of the route were identified. The overall yield of cordycepin obtained from adenosine as the starting material was 36%.",
        "keywords": [
            "Adenosine",
            " Deoxyadenosine",
            " Cordycepin",
            " Synthesis"
        ],
        "authors": [
            {
                "name": "Shen Huang",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Hui Liu",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Yanhua Sun",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Jian Chen",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Xiufang Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Jiangfeng Xu",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Yuwei Hu",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Yuqing Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Zhiwei Deng",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            },
            {
                "name": "Shian Zhong",
                "org": "School of Chemistry and Chemical Engineering, Central South University, Changsha, China"
            }
        ],
        "venue": "Chemical Papers",
        "year": 2018
    },
    "4wgfqZrE": {
        "id": "4wgfqZrE",
        "title": "Graphene oxide as a sacrificial material for fabricating molecularly imprinted polymers via Pickering emulsion polymerization",
        "abstract": "Graphene oxide (GO) was introduced as a sacrificial material, for the first time, to fabricate a hollow molecularly imprinted polymer (HMIP) via Pickering emulsion polymerization. A stable oil-in-water Pickering emulsion was obtained, and the optimum pH values affecting the stability of the emulsion were investigated. After polymerization, GO was peeled off using ammonia solution (pH = 11) via ultrasonication, and substantial specific binding sites were exposed. The physical and chemical properties of the material were characterized and analyzed by scanning electron microscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The equilibrium adsorption could be reached rapidly within 5 min, showing excellent adsorption efficiency, and the equilibrium adsorption capacity was 40.76 mg g\u22121 at 25 \u00b0C. The imprinting factor was about 2.62. The selective analysis indicated a high affinity and selectivity of HMIP toward template diclofenac over mefenamic acid and carbamazepine.",
        "keywords": "",
        "authors": [
            {
                "name": "Yuqing Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Yanhua Sun",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Jian Chen",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Xiaohong Zhu",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Hui Li",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Shen Huang",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Yuwei Hu",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Qi Chen",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            },
            {
                "name": "Shian Zhong",
                "org": "School of Chemistry and Chemical Engineering, Central South University,Changsha 410083,China"
            }
        ],
        "venue": "RSC Advances",
        "year": 2016
    },
    "b9E9M2JF": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": "College of Computer Science and Technology"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "Inertial iteration for split common fixed-point problem for quasi-nonexpansive operators",
        "abstract": "Inspired by the note on split common fixed-point problem for quasi-nonexpansive operators presented by Moudafi (2011), based on the very recent work by Dang et al. (2012), in this paper, we propose an inertial iterative algorithm for solving the split common fixed-point problem for quasi-nonexpansive operators in the Hilbert space. We also prove the asymptotical convergence of the algorithm under some suitable conditions. The results improve and develop previously discussed feasibility problems and related algorithms. \u00a9 2013 Yazheng Dang and Yan Gao.",
        "keywords": [
            ""
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2013,
        "id": "b9E9M2JF"
    },
    "abO7jIWV": {
        "authors": [
            {
                "name": "Xue Mei Hou",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Yan Gao",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Shi Qian Xu",
                "org": "Consulting Institute Corp. Ltd."
            }
        ],
        "title": "Numerical study of the serpentine finned tube used in air cooled condenser",
        "abstract": "the large-diameter flat serpentine finned tube is often used in direct air-cooled condensers. The distribution of the air velocities and the temperatures in the serpentine finned tube were analyzed by using three-dimensional numerical simulation methods. The heat transfer coefficients in finned tubes were obtained, which were subsequently used to fit the relational formulas of the heat transfer coefficients with the changing of air flow velocities in different directions. The results offer great help for operation optimization of air-cooled system under different environmental conditions. \u00a9 2011 IEEE.",
        "keywords": [
            "Air-cooled condenser",
            "Heat transfer coefficient",
            "Numerical simulation",
            "Serpentine finned tube"
        ],
        "venue": "Asia-Pacific Power and Energy Engineering Conference, APPEEC",
        "year": 2011,
        "id": "abO7jIWV"
    },
    "TPtMQOcM": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Ying Liu",
                "org": "Department of Stomatology, Nanfang Hospital, and College of Stomatology"
            },
            {
                "name": "Lei Zhou",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Zehong Guo",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Mingdeng Rong",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Xiangning Liu",
                "org": "Department of Prosthodontics"
            },
            {
                "name": "Chunhua Lai",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Xianglong Ding",
                "org": "Center of Oral Implantology"
            }
        ],
        "title": "The Effects of Different Wavelength UV Photofunctionalization on Micro-Arc Oxidized Titanium",
        "abstract": "Many challenges exist in improving early osseointegration, one of the most critical factors in the long-term clinical success of dental implants. Recently, ultraviolet (UV) light-mediated photofunctionalization of titanium as a new potential surface treatment has aroused great interest. This study examines the bioactivity of titanium surfaces treated with UV light of different wavelengths and the underlying associated mechanism. Micro-arc oxidation (MAO) titanium samples were pretreated with UVA light (peak wavelength of 360 nm) or UVC light (peak wavelength of 250 nm) for up to 24 h. UVC treatment promoted the attachment, spread, proliferation and differentiation of MG-63 osteoblast-like cells on the titanium surface, as well as the capacity for apatite formation in simulated body fluid (SBF). These biological influences were not observed after UVA treatment, apart from a weaker effect on apatite formation. The enhanced bioactivity was substantially correlated with the amount of Ti-OH groups, which play an important role in improving the hydrophilicity, along with the removal of hydrocarbons on the titanium surface. Our results showed that both UVA and UVC irradiation altered the chemical properties of the titanium surface without sacrificing its excellent physical characteristics, suggesting that this technology has extensive potential applications and merits further investigation. \u00a9 2013 Gao et al.",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2013,
        "id": "TPtMQOcM"
    },
    "ZyogHGWW": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "De-Qun Zhou",
                "org": "College of Economics and Management"
            },
            {
                "name": "Chen-Chen Liu",
                "org": "College of Information and Engineering"
            },
            {
                "name": "Ling Zhang",
                "org": "College of Economics and Management"
            }
        ],
        "title": "Triangular fuzzy number intuitionistic fuzzy aggregation operators and their application base on interaction",
        "abstract": "Under triangular fuzzy number intuitionistic information, interaction exists among the decision-making attributes which makes the aggregation operators to lose effectiveness. For these problems, the definition of fuzzy measure is introduced and some operational laws of triangular fuzzy number intuitionistic fuzzy numbers are defined, based on which some new aggregation operators with interaction are developed, such as triangular fuzzy number intuitionistic fuzzy ordered weighted average operation with interaction (R-TPIOWA), triangular fuzzy number intuitionistic fuzzy weighted geometric average operation with interaction (R-TPIWGA) and triangular fuzzy number intuitionistic fuzzy ordered weighted geometric average operation with interaction (R-TPIOWGA). Finally, an approach for decision making with triangular fuzzy number intuitionistic fuzzy information is developed, and a practical example is provided to illustrate the developed approach and to verify its effectiveness.",
        "keywords": [
            "Group decision making",
            "Interaction",
            "Operational laws",
            "Three-point interval number intuitionistic fuzzy set"
        ],
        "venue": "Xitong Gongcheng Lilun yu Shijian/System Engineering Theory and Practice",
        "year": 2012,
        "id": "ZyogHGWW"
    },
    "Ie4RRElj": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Mechanical Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Jiwei Peng",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Hongming Xu",
                "org": "School of Mechanical Engineering"
            }
        ],
        "title": "Performance of V2O5-WO3 -MoO3/TiO2 catalyst for diesel engine NH3-SCR system",
        "abstract": "A catalyst of V",
        "keywords": [
            "Diesel engine",
            "NH3",
            "NOx",
            "SCR",
            "V2O5 -WO3-MoO3/TiO2"
        ],
        "venue": "Huagong Xuebao/CIESC Journal",
        "year": 2013,
        "id": "Ie4RRElj"
    },
    "Ct0xiwVL": {
        "authors": [
            {
                "name": "Hui Zhang",
                "org": "Engineering Research Center for Transportation Safety"
            },
            {
                "name": "Xinping Yan",
                "org": "Engineering Research Center for Transportation Safety"
            },
            {
                "name": "Yan Gao",
                "org": "Traffic Management Research Institute"
            },
            {
                "name": "Chaozhong Wu",
                "org": "Engineering Research Center for Transportation Safety"
            },
            {
                "name": "Pingfan Li",
                "org": "Traffic Management Research Institute"
            }
        ],
        "title": "Relationship between driver safety cognition and vehicle speed based on fuzzy comprehensive evaluation",
        "abstract": "To evaluate the effect of driver subjective cognition of highway safety level on vehicle speed, the real vehicle experiment was designed. Fifty drivers were invited to determine the weight of the highway parameters which is related to driving safety. Based on the subjective evaluation of 719 drivers on highway safety level of horizontal, vertical alignments and sight distance, the fuzzy comprehensive model of safety level was established, and the driving speeds at different section of evaluated highway were collected. The results show that the vehicle speed on each road section is closely related with the subjective cognition of road safety level which is based on the fuzzy comprehensive evaluation model. Considering the insecurity of next approach road section, the driver will decrease the speed to ensure safety. The evaluation model is effective for simulating the process that driver chooses safe speed based on safety degree of highway.",
        "keywords": [
            "Driving speed",
            "Fuzzy comprehensive evaluation",
            "Real vehicle experiment",
            "Subjective cognition",
            "Traffic safety"
        ],
        "venue": "Jiangsu Daxue Xuebao (Ziran Kexue Ban)/Journal of Jiangsu University (Natural Science Edition)",
        "year": 2011,
        "id": "Ct0xiwVL"
    },
    "azNX0mMN": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Xuewen Li",
                "org": "Department of Applied Mathematics"
            }
        ],
        "title": "Nonsmooth equations approach to a constrained minimax problem",
        "abstract": "An equivalent model of nonsmooth equations for a constrained minimax problem is derived by using a KKT optimality condition. The Newton method is applied to solving this system of nonsmooth equations. To perform the Newton method, the computation of an element of the b-differential for the corresponding function is developed. \u00a9 2005 Springer Science+Business Media, Inc.",
        "keywords": [
            "KKT systems",
            "minimax problems",
            "Newton methods",
            "nonsmooth equations",
            "nonsmooth optimization",
            "quasidifferential calculus"
        ],
        "venue": "Applications of Mathematics",
        "year": 2005,
        "id": "azNX0mMN"
    },
    "shfx2dZt": {
        "authors": [
            {
                "name": "Zheng Chen",
                "org": "School of Sciences"
            },
            {
                "name": "Yan Gao",
                "org": "Business School"
            }
        ],
        "title": "Computation of approximate viable sets for linear systems",
        "abstract": "We investigate the approximate viability conditions for linear control systems and the method of constructing approximate viable sets for control systems. Based on the proximal normal cone, a surplus viable set for a convex compact set is given, which can approximate the real viable set if the number of sample points on the boundary of the convex compact set is large enough. For continuous-time linear systems and discrete-time linear systems, the method to verify the viability of approximate viable set is given. Furthermore, the problem of viable controller design is formulated as a linear inequalities problem. Finally, we illustrate the effectiveness of the main results of this paper with a pendulum model with a movable suspension point and the other model of two types of bacteria.",
        "keywords": [
            "Linear control systems",
            "Normal cone",
            "Polytope",
            "Viability"
        ],
        "venue": "Kongzhi Lilun Yu Yingyong/Control Theory and Applications",
        "year": 2013,
        "id": "shfx2dZt"
    },
    "zxgWkajO": {
        "authors": [
            {
                "name": "Pengjun Zhang",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            },
            {
                "name": "Ping Lan",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            },
            {
                "name": "Yuening Ma",
                "org": "Marine College"
            },
            {
                "name": "Yan Gao",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            },
            {
                "name": "Hao Chen",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            },
            {
                "name": "Qian Fang",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            },
            {
                "name": "Wansong Zong",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            },
            {
                "name": "Rutao Liu",
                "org": "Shandong Key Laboratory of Water Pollution Control and Resource Reuse"
            }
        ],
        "title": "Spectroscopic investigation on the interaction of Cr(VI) with bovine serum albumin",
        "abstract": "The interaction of potassium dichromate (Cr(VI)) with bovine serum albumin (BSA) was investigated by fluorescence, synchronous fluorescence, resonance light scattering (RLS), ultraviolet-visible absorption, and circular dichroism (CD) spectroscopies under simulated physiological conditions. The experimental results showed that Cr(VI) could quench the intrinsic fluorescence of BSA following a static quenching process, which indicates the formation of a Cr(VI)-BSA complex. The binding constant (K ",
        "keywords": [
            "Bovine Serum Albumin",
            "Cr(VI)",
            "Interaction",
            "Spectroscopic Techniques"
        ],
        "venue": "Journal of Biochemical and Molecular Toxicology",
        "year": 2012,
        "id": "zxgWkajO"
    },
    "Go6iZTya": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": "Henan Polytechnic University"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "Weak and strong convergence of an algorithm for the split common fixed-point of asymptotically quasi-nonexpansive operators",
        "abstract": "Inspired by the Moudafi (2010), we propose an algorithm for solving the split common fixed-point problem for a wide class of asymptotically quasi-nonexpansive operators and the weak and strong convergence of the algorithm are shown under some suitable conditions in Hilbert spaces. The algorithm and its convergence results improve and develop previous results for split feasibility problems. \u00a9 2013 Yazheng Dang and Yan Gao.",
        "keywords": [
            ""
        ],
        "venue": "Mathematical Problems in Engineering",
        "year": 2013,
        "id": "Go6iZTya"
    },
    "xhrjVBu3": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Jiwei Peng",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao L\u00fc",
                "org": "School of Energy and Power Engineering"
            }
        ],
        "title": "DeNOx performance of SCR catalyst for exhaust gas from coal-fired power plant",
        "abstract": "A honeycomb SCR catalyst of V",
        "keywords": [
            "Coal-fired power plant",
            "NH3",
            "NOx",
            "SCR",
            "SO2"
        ],
        "venue": "Huagong Xuebao/CIESC Journal",
        "year": 2013,
        "id": "xhrjVBu3"
    },
    "zYbWAWf9": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "School of Mathematics and Statistics"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Zun-Quan Xia",
                "org": "School of Mathematical Sciences"
            }
        ],
        "title": "Advances on stability for switched linear systems",
        "abstract": "The study of the stability analysis and the switching stabilization for switched linear systems is a hot topic in recent years. The lately main results about this problem are reviewed in this paper. Firstly, the primary conclusions of the stability analysis are given for switched linear systems under two cases such that the arbitrary switching and the restricted switching. Then the main methods for switching stabilization are presented. Finally, the current results of the practical stability and the finite-time stability problems for switched systems are outlined, and the development of this research field is forecasted.",
        "keywords": [
            "Hybrid systems",
            "Multiple Lyapunov function",
            "Nonsmooth Lyapunov function",
            "Slow switching",
            "Stability",
            "Switched systems"
        ],
        "venue": "Kongzhi yu Juece/Control and Decision",
        "year": 2010,
        "id": "zYbWAWf9"
    },
    "xLC6SBNV": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": "School of Management"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "The strong convergence of a KM-CQ-like algorithm for a split feasibility problem",
        "abstract": "It is well known that the Krasnosel'skii-Mann algorithm and the CQ algorithm for a split feasibility problem are not strongly convergent. In this paper, we present a KM-CQ-like algorithm with strong convergence, which combines the KM algorithm with the CQ algorithm by introducing two parameter sequences for solving the split feasibility problem. Under some parametric controlling conditions, the strong convergence of the algorithm is shown. Finally, we propose amodified KM-CQ-like algorithm and establish its strong convergence theorem. \u00a9 2011 IOP Publishing Ltd.",
        "keywords": [
            ""
        ],
        "venue": "Inverse Problems",
        "year": 2011,
        "id": "xLC6SBNV"
    },
    "Dtbmu4iF": {
        "authors": [
            {
                "name": "Xiangning Liu",
                "org": "The First Affiliated Hospital of Jinan University"
            },
            {
                "name": "Xiaoran Li",
                "org": "Suzhou Institute of Nano-tech and Nano-bionics"
            },
            {
                "name": "Lei Zhou",
                "org": "The Affiliated Stomatological Hospital of Southern Medical Univ."
            },
            {
                "name": "Shaobing Li",
                "org": "The Affiliated Stomatological Hospital of Southern Medical Univ."
            },
            {
                "name": "Jie Sun",
                "org": "Suzhou Institute of Nano-tech and Nano-bionics"
            },
            {
                "name": "Zhonglei Wang",
                "org": "Southern Medical University"
            },
            {
                "name": "Yan Gao",
                "org": "Southern Medical University"
            },
            {
                "name": "Ying Jiang",
                "org": "Southern Medical University"
            },
            {
                "name": "Haibin Lu",
                "org": "Southern Medical University"
            },
            {
                "name": "Qiangbin Wang",
                "org": "Suzhou Institute of Nano-tech and Nano-bionics"
            },
            {
                "name": "Jianwu Dai",
                "org": "Key Laboratory of Molecular Developmental Biology"
            }
        ],
        "title": "Effects of simvastatin-loaded polymeric micelles on human osteoblast-like MG-63 cells",
        "abstract": "To develop an optimized simvastatin (SV) delivery device for bone regeneration, SV-loaded poly(ethylene glycol)-poly(e{open}-caprolactone) (PECL) micelles were constructed. The micelles had an average size of 80nm. The in vitro release behavior of SV from the micelles showed prolonged release compared to the free SV. The following four groups were tested in a cytologic experiment: a free SV group, a SV-loaded micelle group with SV concentrations ranging from 2.5\u00d710",
        "keywords": [
            "Bone regeneration",
            "Delivery system",
            "Micelle",
            "Osteoblast",
            "Simvastatin"
        ],
        "venue": "Colloids and Surfaces B: Biointerfaces",
        "year": 2013,
        "id": "Dtbmu4iF"
    },
    "M1lnqXLU": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "Piecewise smooth lyapunov function for a nonlinear dynamical system",
        "abstract": "In this paper, stability and attraction for a nonlinear dynamical system with nonsmooth Lyapunov functions are studied. The previous results on stability and attraction with a max-type Lyapunov function are extended to the case where Lyapunov function is piecewise smooth. A condition, under which stability and attraction are guaranteed with a piecewise smooth Lyapunov function, is proposed. Taking two certain classes of piecewise smooth functions as Lyapunov functions, related conditions for stability and attraction are developed. \u00a9 Heldermann Verlag.",
        "keywords": [
            "Lyapnov functions",
            "Nonlinear dynamical system",
            "Nonsmooth analysis",
            "Piecewise smooth function",
            "Region of attraction",
            "Stability"
        ],
        "venue": "Journal of Convex Analysis",
        "year": 2012,
        "id": "M1lnqXLU"
    },
    "Mp5aPd9W": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": ""
            },
            {
                "name": "Tao Luan",
                "org": ""
            },
            {
                "name": "Tao L\u00fc",
                "org": ""
            },
            {
                "name": "Kai Cheng",
                "org": ""
            },
            {
                "name": "Hongming Xu",
                "org": ""
            }
        ],
        "title": "Performance of V2O5-WO3-MoO 3/TiO2 catalyst for selective catalytic reduction of NOx by NH3",
        "abstract": "The V",
        "keywords": [
            "flue gas",
            "life time",
            "physico-chemical property",
            "selective catalytic reduction",
            "V2O5-WO 3-MoO3/TiO2 catalyst"
        ],
        "venue": "Chinese Journal of Chemical Engineering",
        "year": 2013,
        "id": "Mp5aPd9W"
    },
    "08m38uBC": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Mechanical Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Lv",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Hongming Xu",
                "org": "School of Mechanical Engineering"
            }
        ],
        "title": "The mo loading effect on thermo stability and SO2 oxidation of SCR catalyst",
        "abstract": "The SCR catalysts were produced with V",
        "keywords": [
            "MoO3",
            "NO",
            "SCR",
            "SO2",
            "TG"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "08m38uBC"
    },
    "1ZyeThCv": {
        "authors": [
            {
                "name": "Yuanyuan Chen",
                "org": ""
            },
            {
                "name": "Yan Gao",
                "org": ""
            }
        ],
        "title": "Global convergence of a nonlinear extended hybrid conjugate gradient method with wolfe type line search",
        "abstract": "The nonlinear FR conjugate gradient method, nonlinear PRP conjugate gradient method, nonlinear DY conjugate gradient method etc. for large scale unconstrained optimization problems were described. The nonlinear extended hybrid conjugate gradient method, which is more efficient for solving unconstrained optimization problems, was stressed and a new nonlinear extended hybrid conjugate gradient method with Wolfe type line search was proposed. The direction generated by the new method produces sufficiently descentding search direction. Under some conditions, the global convergence of the new method was investigated. Some numerical results show its efficiency.",
        "keywords": [
            "Global convergence",
            "Line search",
            "Nonlinear extended hybrid conjugate gradient method",
            "Unconstrained optimization"
        ],
        "venue": "Shanghai Ligong Daxue Xuebao/Journal of University of Shanghai for Science and Technology",
        "year": 2013,
        "id": "1ZyeThCv"
    },
    "q3Qclgw2": {
        "authors": [
            {
                "name": "Zheng Chen",
                "org": ""
            },
            {
                "name": "Yan Gao",
                "org": ""
            }
        ],
        "title": "Two classes of common Lyapunov functions for switched systems",
        "abstract": "The existence of common Lyapunov functions for switched systems is studied. For a special positive switched systems, a sufficient condition for the existence of common Lyapunov functions is given. While the system matrices are a compact set of second order matrices, a method of determining the existence of common Lyapunov functions is obtained, and an algorithm of common Lyapunov function is presented. Finally, some examples are given to verify the effectiveness of the proposed method.",
        "keywords": [
            "Common Lyapunov functions",
            "Stability",
            "Switched systems"
        ],
        "venue": "Kongzhi yu Juece/Control and Decision",
        "year": 2013,
        "id": "q3Qclgw2"
    },
    "CDx5qbOw": {
        "authors": [
            {
                "name": "Chun-Hua Lai",
                "org": "Guangdong Provincial Stomatological Hospital"
            },
            {
                "name": "Lei Zhou",
                "org": "Guangdong Provincial Stomatological Hospital"
            },
            {
                "name": "Zhong-Lei Wang",
                "org": "Department of Dental Implants"
            },
            {
                "name": "Hai-Bin Lu",
                "org": "Guangdong Provincial Stomatological Hospital"
            },
            {
                "name": "Yan Gao",
                "org": "Guangdong Provincial Stomatological Hospital"
            }
        ],
        "title": "Use of a collagen membrane loaded with recombinant human bone morphogenetic protein-2 with collagen-binding domain for vertical guided bone regeneration",
        "abstract": "Background: Vertical bone regeneration of severe atrophic alveolar ridges remains a challenging procedure in implant dentistry. Methods: The aim of this study, accordingly, is to use a rabbit vertical guided bone regeneration model to evaluate whether using a collagen membrane (CM) loaded with small doses of recombinant human bone morphogenetic protein-2 with collagen-binding domain (rhBMP-2/CBD) would enhance two-way vertical bone regeneration. In each of eight rabbits, four titanium cylinders were screwed in perforated slits made into the external cortical bones of the calvaria. The following four treatment modalities were randomly allocated: 1) cylinders filled with mineralized bone matrix and covered with CM/rhBMP-2/CBD; 2) cylinders filled with mineralized bone matrix and covered with CM/rhBMP-2; 3) cylinders filled with mineralized bone matrix and covered with CM alone; or 4) cylinders filled with mineralized bone matrix without a membrane cover. Results: After 6 weeks, the new bones were examined by histologic analysis. Slender new bone trabeculae were observed in the superficial layer of the titanium cylinders covered with CM/rhBMP-2/CBD, and higher degrees of bone were observed in this group compared with the other three groups. The average area fraction of newly formed bone was significantly more in the CM/rhBMP-2/CBD group compared with the CM/rhBMP-2, CM, or the no membrane control groups (all P<0.01). Conclusions: The present study demonstrates that CMs loaded with small doses of rhBMP-2/CBD induce new bone formation not only from the surface of the native bone, but also from the superficial structures. The augmented new bone, therefore, is improved in both quantity and quality.",
        "keywords": [
            "Alveolar ridge augmentation",
            "Animal experimentation",
            "Bone morphogenetic protein 2",
            "Bone regeneration",
            "Collagen",
            "Dental implants"
        ],
        "venue": "Journal of Periodontology",
        "year": 2013,
        "id": "CDx5qbOw"
    },
    "4MSjvEWt": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "School of Information"
            },
            {
                "name": "Zun-Quan Xia",
                "org": "School of Mathematical Sciences"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "Exponential stabilizability of switched systems with polytopic uncertainties",
        "abstract": "The exponential stabilizability of switched nonlinear systems with polytopic uncertainties is explored by employing the methods of nonsmooth analysis and the minimum quadratic Lyapunov function. The switchings among subsystems are dependent on the directional derivative along the vertex directions of subsystems. In particular, a sufficient condition for exponential stabilizability of the switched nonlinear systems is established considering the sliding modes and the directional derivatives along sliding modes. Furthermore, the matrix conditions of exponential stabilizability are derived for the case of switched linear system and the numerical example is given to show the validity of the synthesis results. \u00a9 2012 Xia Zhang et al.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Applied Mathematics",
        "year": 2012,
        "id": "4MSjvEWt"
    },
    "KBWOS8ED": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "Business Administration Post Doctor Research Station"
            },
            {
                "name": "De-Qun Zhou",
                "org": "College of Economics and Management"
            },
            {
                "name": "Chen-Chen Liu",
                "org": "College of Information and Engineering"
            },
            {
                "name": "Ling Zhang",
                "org": "College of Economics and Management"
            }
        ],
        "title": "Constructing methods of new buffer operators with variable weights and their inner link",
        "abstract": "Traditional buffer operators can not realize fine tuning of effect intensity, which leads to problems that the effectiveness of buffer action may be too strong or too weak. Considering this situation, several kinds of new buffer operators with variable weights are constructed in this paper, and the inner link among these operators is proposed. At the same time, the corresponding relationship between the strengthening buffer with variable weights and the weakening buffer with variable weights is revealed. The relationship between the regulation degree of buffer operator and their variable weights is defined. The results show that, the regulation degree and variable weights change as the same (opposite) direction, and have nothing to do with \u03b3. The arithmetic buffer operators with variable weights and the geometry buffer operators with variable weights are all special cases of these constructed buffer operators with variable weights.",
        "keywords": [
            "Buffer operator with variable weights",
            "Effect strength",
            "Forecasting",
            "Grey system"
        ],
        "venue": "Xitong Gongcheng Lilun yu Shijian/System Engineering Theory and Practice",
        "year": 2013,
        "id": "KBWOS8ED"
    },
    "9qykMB40": {
        "authors": [
            {
                "name": "Zheng Xing",
                "org": "School of Management"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Jin Dong",
                "org": "IBM China Research Laboratory"
            }
        ],
        "title": "SD model in electric vehicle charging system",
        "abstract": "Using electric vehicle can effectively alleviate the energy crisis and environmental pollution and the researches on electricity-related problem are very necessary and urgent. First, this paper analyzes the new power industry chain structure of EV charging system and establishes the related system dynamics model taking into account the economy of the industry chain. Then, it collects the basic data from a specific scale of EV charging system, uses the Vensim software to operate the system simulation through changing values of profit rate, profit adjustment rate, electricity price sensitivity, and so on. It quantifies the electricity consumption and charging price, and gets equilibrium values and curves related to both investment recovery period and electric charging models to search for the optimal decision reference, which has a realistic significance. Finally, the paper summarizes the advantages and disadvantages of the model and gives some suggestions for model improvement.",
        "keywords": [
            "Balance of interests",
            "Electric vehicle charging system",
            "System dynamics",
            "Systems engineering"
        ],
        "venue": "Jiaotong Yunshu Xitong Gongcheng Yu Xinxi/Journal of Transportation Systems Engineering and Information Technology",
        "year": 2012,
        "id": "9qykMB40"
    },
    "nPmQIZED": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": ""
            },
            {
                "name": "Yan Gao",
                "org": ""
            }
        ],
        "title": "The strong convergence of a three-step algorithm for the split feasibility problem",
        "abstract": "Based on the very recent work by Dang and Gao (Invers Probl 27:1-9, 2011) and Wang and Xu (J Inequal Appl, doi:10.1155/2010/102085, 2010), and inspired by Yao (Appl Math Comput 186:1551-1558, 2007), Noor (J Math Anal Appl 251:217-229, 2000), and Xu (Invers Probl 22:2021-2034, 2006), we suggest a three-step KM-CQ-like method for solving the split common fixed-point problems in Hilbert spaces. Our results improve and develop previously discussed feasibility problem and related algorithms. \u00a9 2012 Springer-Verlag.",
        "keywords": [
            "KM-CQ-like algorithm",
            "Noor three-step method",
            "Split feasibility problem",
            "Strong convergence"
        ],
        "venue": "Optimization Letters",
        "year": 2013,
        "id": "nPmQIZED"
    },
    "2omC5hpZ": {
        "authors": [
            {
                "name": "Dan Tian",
                "org": "School of Management"
            },
            {
                "name": "Wenhui Zhao",
                "org": "School of Economics and Management"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "Validity of emission trading market based on multilevel grey evaluation method",
        "abstract": "Evaluating emission trading market is a complex and important process and it is significant for the development of emission trading market. The paper designed an evaluation index system of emission trading market based on past work. In addition, we presented an evaluation method that combined Analytic Hierarchy Process (AHP) and grey evaluation method. This method improves the objectiveness and reasonableness of the evaluation process, as well as it is utilitarian and comprehensive. In order to verify the rationality of the evaluation index system and the effectiveness of the evaluation methods, the emission trading market of sulfur dioxide in the Yangtze River was evaluated. \u00a9 2010 IEEE.",
        "keywords": [
            "AHP",
            "Emission trading market",
            "Evaluation index system",
            "Grey evaluation method component"
        ],
        "venue": "Proceedings - 2010 2nd International Conference on Intelligent Human-Machine Systems and Cybernetics, IHMSC 2010",
        "year": 2010,
        "id": "2omC5hpZ"
    },
    "4sLp6wFh": {
        "authors": [
            {
                "name": "Wen-Hui Zhao",
                "org": "School of Management"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "A minimax model and arithmetic for initial emission permits",
        "abstract": "To carry the traffic of emission permits into execution, the main problem is how to allocate the initial emission permits. In the condition that the auction and pricing selling of the initial tradable emission permits have obstacle in practice, it is deemed that free allocation of initial tradable emission permits has operation in academia and practice. In this paper, based on economy efficiency and fair principle, we propose a minimax model of initial emission permits. Furthermore, a Karush-KuhnTucker optimality condition and a Newton method to solve the model are given. We consider the case when the correlative functions are nondifferentiable as well as we can make a tradeoff between the economy benefit and fairness according to the model. \u00a9 2006 Korean Society for Computational & Applied Mathematics and Korean SIGCAM.",
        "keywords": [
            "Economic efficiency",
            "fair principles",
            "initial emission permits",
            "minimax model",
            "Newton methods",
            "optimization"
        ],
        "venue": "Journal of Applied Mathematics and Computing",
        "year": 2006,
        "id": "4sLp6wFh"
    },
    "OVM9EAjr": {
        "authors": [
            {
                "name": "Ying Li",
                "org": "College of Mathematics Science"
            },
            {
                "name": "Yan Gao",
                "org": "Business School"
            }
        ],
        "title": "Mixed absorption laws of the sum of two matrices on {1, 2}-inverse and {1, 3}-inverse",
        "abstract": "The concepts of the mixed first absorption laws and the mixed second absorption laws on generalized inverse were given. Using the matrix rank method, the generalized Schur complement and singular value decomposition (SVD), necessary and sufficient conditions about the mixed first absorption laws and the mixed second absorption laws on {1, 2}-inverse and {1, 3}-inverse were established.",
        "keywords": [
            "Generalized Schur complement",
            "M-P inverse",
            "Matrix rank method",
            "Mixed absorption laws",
            "Singular value decomposition",
            "{i, j, k}-inverse"
        ],
        "venue": "Shanghai Ligong Daxue Xuebao/Journal of University of Shanghai for Science and Technology",
        "year": 2011,
        "id": "OVM9EAjr"
    },
    "bOEL0xr3": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Ji-Wei Peng",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Lv",
                "org": "School of Energy and Power Engineering"
            }
        ],
        "title": "DeNOx performance of quaternary SCR V2O5-WO3 -MoO3/TiO2 catalyst",
        "abstract": "The quaternary SCR catalyst was prepared with anatase TiO",
        "keywords": [
            "Catalyst",
            "DeNOx",
            "NO",
            "SCR",
            "SO2"
        ],
        "venue": "Gongneng Cailiao/Journal of Functional Materials",
        "year": 2013,
        "id": "bOEL0xr3"
    },
    "5ziu1SvZ": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": "School of Management"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "A new simultaneous subgradient projection algorithm for solving a multiple-sets split feasibility problem",
        "abstract": "In this paper, we present a simultaneous subgradient algorithm for solving the multiple-sets split feasibility problem. The algorithm employs two extrapolated factors in each iteration, which not only improves feasibility by eliminating the need to compute the Lipschitz constant, but also enhances flexibility due to applying variable step size. The convergence of the algorithm is proved under suitable conditions. Numerical results illustrate that the new algorithm has better convergence than the existing one. \u00a9 2014 Institute of Mathematics of the Academy of Sciences of the Czech Republic, Praha, Czech Republic.",
        "keywords": [
            "extrapolated technique",
            "multiple-sets split feasibility problem",
            "subgradient"
        ],
        "venue": "Applications of Mathematics",
        "year": 2014,
        "id": "5ziu1SvZ"
    },
    "2MWU3eDR": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": "School of Mathematics and Information Science"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "An extrapolated iterative algorithm for multiple-set split feasibility problem",
        "abstract": "The multiple-set split feasibility problem (MSSFP), as a generalization of the split feasibility problem, is to find a point in the intersection of a family of closed convex sets in one space such that its image under a linear transformation will be in the intersection of another family of closed convex sets in the image space. Censor et al. (2005) proposed a method for solving the multiple-set split feasibility problem (MSSFP), whose efficiency depends heavily on the step size, a fixed constant related to the Lipschitz constant of p(x) which may be slow. In this paper, we present an accelerated algorithm by introducing an extrapolated factor to solve the multiple-set split feasibility problem. The framework encompasses the algorithm presented by Censor et al. (2005). The convergence of the method is investigated, and numerical experiments are provided to illustrate the benefits of the extrapolation. Copyright \u00a9 2012 Yazheng Dang and Yan Gao.",
        "keywords": [
            ""
        ],
        "venue": "Abstract and Applied Analysis",
        "year": 2012,
        "id": "2MWU3eDR"
    },
    "WtLWlmhi": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Mechanical Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Lv",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Hongming Xu",
                "org": "School of Mechanical Engineering"
            }
        ],
        "title": "The Mo loading effect on SCR deNOx performance for V-W-Mo/TiO2 catalyst",
        "abstract": "The V(1)-W(4.5)-Mo(x)/TiO2 catalysts was prepared by the incipient dry impregnationmethod. The catalyst samples were ground and sieved for 0.3~0.6 mm. The NO catalytic efficiency, selectivity against N2O of the catalysts were investigated on a fixed bed reactor under simulated exhaust gas with a typical gas composition. The addition of Mo enhanced the catalytic efficiency of V(1)-W(4.5)-Mo(x)/TiO2 catalysts at low temperature region, while lessened that at high temperature, especially at the temperature above 400 \u00b0C. Increasing the loading of Mo from 1.5% w/w to 4.5% w/w advanced the maximum catalytic efficiency from 78% to 99% and enlarged the temperature window of the catalyst. The acceptable NO conversion (>60%) was attained at temperature as low as 240 \u00b0C for V(1)-W(4.5)-Mo(7.5)/TiO2 catalyst. The presence of Mo promoted the N2O generation. The V(1)-W(4.5)-Mo(0)/",
        "keywords": [
            "MO",
            "N2O",
            "NH3",
            "NO",
            "SCR"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2012,
        "id": "WtLWlmhi"
    },
    "WBFYk2s7": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "College of Economics and Management"
            },
            {
                "name": "Zhijie Leng",
                "org": "College of Economics and Management"
            }
        ],
        "title": "Constructing evaluation index system of agricultural products supply chain develop circular economic microeconomic organization in process stage",
        "abstract": "Through comprehensive analysis of the factors about the supply chain of agricultural products in process stage to develop agricultural cycle of economic, we established an evaluation index system, which includes 5 level indicators and 16 secondary indicators. The level indicators are the production efficiency, resource recycling degree, environmental protection performance, client report, Innovation and development ability. Based on the evaluation indexes for establishing principles and the analysis of the affecting factors, and established the process stages of developing circular economy microstructure evaluation index system, which the key members develop circular economy, and we used this method to evaluate the agricultural products supply chain in process stage developing circular economy, evaluation results can help for the Government to find suitable investors, it can also provide evidence and guidance for the government investment or to promote circular economy project. \u00a9 2013 IEEE.",
        "keywords": [
            "Agricultural products supply chain",
            "Cycle of economic",
            "Evaluation index system",
            "microstructure",
            "process stage"
        ],
        "venue": "Proceedings of 2013 6th International Conference on Information Management, Innovation Management and Industrial Engineering, ICIII 2013",
        "year": 2013,
        "id": "WBFYk2s7"
    },
    "7BJuOGvW": {
        "authors": [
            {
                "name": "Yazheng Dang",
                "org": "Department of Mathematics and Information Science"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Yanli Han",
                "org": "Department of Mathematics and Information Science"
            }
        ],
        "title": "A perturbed projection algorithm with inertial technique for split feasibility problem",
        "abstract": "This paper deals with the split feasibility problem that requires to find a point closest to a closed convex set in one space such that its image under a linear transformation will be closest to another closed convex set in the image space. By combining perturbed strategy with inertial technique, we construct an inertial perturbed projection algorithm for solving the split feasibility problem. Under some suitable conditions, we show the asymptotic convergence. The results improve and extend the algorithms presented in Byrne (2002) and in Zhao and Yang (2005) and the related convergence theorem. \u00a9 Copyright 2012 Yazheng Dang et al.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Applied Mathematics",
        "year": 2012,
        "id": "7BJuOGvW"
    },
    "lSf4CDPZ": {
        "authors": [
            {
                "name": "Lei Liu",
                "org": "School of Management, University of Shanghai for Science and Technology"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management, University of Shanghai for Science and Technology"
            },
            {
                "name": "Yue-Peng Wu",
                "org": "Optical-electrical School, University of Shanghai for Science and Technology"
            }
        ],
        "title": "High speed navigation control of nonholonomic wheeled robot based on viability theory",
        "abstract": "Since the wheeled robot is nonholonomic, the driving of such system is complex. The current autonomous navigation control of the wheeled robot seems to be conservative. Most control methods are difficult to achieve high-speed navigation in an obstacle environ- ment, because the robot driving, obstacle avoidance and goal guidance can not be integrated systematically under the current theoretical framework. In this paper, viability theory is first time introduced in the navigation control of nonholonomic robot with three steps. Firstly, the viability boundary is constructed by environmental feature extraction. Secondly, the viability boundary is applied to build the viability condition constraints. Thirdly, the optimized high speed navigation control can be obtained in numerical way with viability condition constraints. The simulation shows that, the viability control can overcome the driving problem of the non- holonomic robot, and meanwhile realize the radical high-speed navigation.",
        "keywords": [
            "High speed navigation",
            "Non-holonomic constraint",
            "Obstacle avoidance",
            "Viability control",
            "Wheeled robot"
        ],
        "venue": "OPT-i 2014 - 1st International Conference on Engineering and Applied Sciences Optimization, Proceedings",
        "year": 2014,
        "id": "lSf4CDPZ"
    },
    "W0pGBngc": {
        "authors": [
            {
                "name": "Ying Li",
                "org": ""
            },
            {
                "name": "Yan Gao",
                "org": ""
            },
            {
                "name": "Wen-Bin Guo",
                "org": ""
            }
        ],
        "title": "Commutative law and generalized commutative law of matrix multiplication on generalized inverse",
        "abstract": "The concepts of the commutative laws and generalized commutative laws of matrix multiplication on generalized inverse were defined. Using the matrix rank method and SVD, necessary and sufficient conditions about the commutative laws and generalized commutative laws of matrix multiplication on {1}inverse,{1,2}inverse,{1,3}inverse and {1,4}inverse were established respectively, and these conditions were compared between themselves.",
        "keywords": [
            "Commutative laws",
            "Generalized Schur complement",
            "Group inverse",
            "Matrix rank method",
            "Singular value decomposition",
            "{i,j,k}inverse"
        ],
        "venue": "Shanghai Ligong Daxue Xuebao/Journal of University of Shanghai for Science and Technology",
        "year": 2011,
        "id": "W0pGBngc"
    },
    "FzTMzDLv": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": ""
            },
            {
                "name": "Ling Zhang",
                "org": ""
            },
            {
                "name": "Dequn Zhou",
                "org": ""
            }
        ],
        "title": "Performance evaluation of coal enterprises energy conservation and reduction of pollutant emissions base on GRD-TOPSIS",
        "abstract": "For the performance evaluation of coal enterprises energy conservation and reduction of pollutant emission, a new GRD-TOPSIS method is proposed. By analyzing the background of performance evaluation of energy conservation and reduction of pollutant emission, the performance evaluation system of coal enterprises is established. Three coal enterprises of Yanzhou City are selected as evaluation objects, and use the new method to evaluate their performance of energy conservation and reduction of pollutant emission. The practical example shows the feasibility and effectiveness of the proposed method. \u00a9 2011 Published by Elsevier Ltd.",
        "keywords": [
            "Energy conservation and reduction of pollutant emission",
            "GRD-TOPSIS",
            "MADM"
        ],
        "venue": "Energy Procedia",
        "year": 2011,
        "id": "FzTMzDLv"
    },
    "9bpVfvr8": {
        "authors": [
            {
                "name": "Ji Wei Peng",
                "org": ""
            },
            {
                "name": "Tao Luan",
                "org": ""
            },
            {
                "name": "Yan Gao",
                "org": ""
            }
        ],
        "title": "The W loading effect on SCR deNOx performance for V-W-Mo/TiO2catalyst",
        "abstract": "The SCR catalysts were produced with V",
        "keywords": [
            "N2O",
            "NH3",
            "NO",
            "SCR",
            "W"
        ],
        "venue": "Advanced Materials Research",
        "year": 2013,
        "id": "9bpVfvr8"
    },
    "njrp2YLd": {
        "authors": [
            {
                "name": "Yaxin Yi",
                "org": "Center for the Studies of Information Resources"
            },
            {
                "name": "Yan Gao",
                "org": "School of Economics and Management"
            }
        ],
        "title": "Research on enterprise competitive strategy based on value-net",
        "abstract": "The value-net is the product of the rapid development of information economy. It is a new business design that uses digital supply chain concepts to achieve both superior customer satisfaction and company profitability, and coordinates member firms within the value-net, and extracts the core capabilities of the value creation. This paper introduces the concept and model of value-net, and constructs a enterprise competitive strategy based on value-net by analyzing Porter's traditional competitive strategy, and also presents the implementation of enterprise competitive strategy based on value-net. Furthermore, the author attempts to shed light on application methods for practitioners on their business initiatives. \u00a9 2010 IEEE.",
        "keywords": [
            "Competitive strategy",
            "Cooperative competition",
            "Value-chain",
            "Value-net",
            "Value-net model"
        ],
        "venue": "Proceedings of the International Conference on E-Business and E-Government, ICEE 2010",
        "year": 2010,
        "id": "njrp2YLd"
    },
    "ZswDiEFU": {
        "authors": [
            {
                "name": "Zhi-E Lou",
                "org": "Department of Mathematics and Physics"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "The exponential stability for a class of hybrid systems",
        "abstract": "The exponential stability with a nonsmooth Lyapunov function for a class of hybrid systems is studied in this paper. First, a sufficient condition is derived that has to be satisfied by the feedback control for the hybrid systems. Then, for the special case where the Lyapunov function involved is a kind of nonsmooth function, the maximum of finitely many smooth functions (for short, max-type function), the stability of a hybrid system is considered, and a convenient criterion to determine the stability of the system is established. Finally, a numerical method of determining the control input value is developed. \u00a9 2012 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society.",
        "keywords": [
            "exponential stability",
            "Hybrid systems",
            "nonsmooth analysis",
            "viability"
        ],
        "venue": "Asian Journal of Control",
        "year": 2013,
        "id": "ZswDiEFU"
    },
    "YacIfUbG": {
        "authors": [
            {
                "name": "Xianglong Ding",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Xiaoqin Yang",
                "org": "Department of Oral and Maxillofacial Surgery"
            },
            {
                "name": "Lei Zhou",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Haibin Lu",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Shaobing Li",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Yan Gao",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Chunhua Lai",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Ying Jiang",
                "org": "Center of Oral Implantology"
            }
        ],
        "title": "Titanate nanowire scaffolds decorated with anatase nanocrystals show good protein adsorption and low cell adhesion capacity",
        "abstract": "Background and methods: In this report, layered microporous titanate nanowire scaffolds (TiNWs) were constructed via a hydrothermal route and then decorated with anatase nanocrystals (ANs@TiNWs) by immersion in TiCl",
        "keywords": [
            "Antiadhesion",
            "Drug delivery",
            "Nanotopography",
            "Protein adsorption"
        ],
        "venue": "International Journal of Nanomedicine",
        "year": 2013,
        "id": "YacIfUbG"
    },
    "mIz59gHA": {
        "authors": [
            {
                "name": "Hao Zheng",
                "org": "Business School"
            },
            {
                "name": "Yan Gao",
                "org": "Business School"
            }
        ],
        "title": "Dispatching model and algorithm for multi-resource emergency systems",
        "abstract": "Considering the multi-objective, dynamic, uncertain and time-sensitive features of emergency resource scheduling, the fast reaction time was focused as an important research subject. According to the characteristic of emergency system, the multi-resource emergency systems model with comsumption rates of nonnegative and integrable functions was introduced. A new model was built based on the object of earliest emergency-start-time, and the corresponding algorithm was provided. The results of empirical research illustrate that the model and the algorithm are both effective and play an active role in emergency resource scheduling. They also provide a theoretical support to emergency scheduling decision.",
        "keywords": [
            "Continuous consumption",
            "Dispatching model",
            "Emergency source dispatching",
            "Multi-resource"
        ],
        "venue": "Shanghai Ligong Daxue Xuebao/Journal of University of Shanghai for Science and Technology",
        "year": 2013,
        "id": "mIz59gHA"
    },
    "PtKDBRLn": {
        "authors": [
            {
                "name": "Shou-Qiang Du",
                "org": "College of Mathematics"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            }
        ],
        "title": "A parametrized newton method for nonsmooth equations with finitely many maximum functions",
        "abstract": "In this paper we propose a parametrized Newton method for nonsmooth equations with finitely many maximum functions. The convergence result of this method is proved and numerical experiments are listed. \u00a9 2009 Mathematical Institute, Academy of Sciences of Czech Republic.",
        "keywords": [
            "convergence",
            "Newton method",
            "nonsmooth equations"
        ],
        "venue": "Applications of Mathematics",
        "year": 2009,
        "id": "PtKDBRLn"
    },
    "mGApZ7XZ": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Hongming Xu",
                "org": "School of Mechanical Engineering"
            },
            {
                "name": "Tao L\u00fc",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Xiaolong Li",
                "org": "School of Energy and Power Engineering"
            }
        ],
        "title": "Sintering temperature effects on SCR catalyst characterization and catalytic efficiency",
        "abstract": "The selective catalytic reduction (SCR) catalyst samples were prepared with different sintering temperatures and subsection sintering programs. Mercury porosimetry and X-ray diffractometer (XRD) diffraction were used to analyze the effects of different sintering temperatures and subsection sintering programs on microstructures of the catalyst, such as specific surface area, pore volume, average pore size, phase transformation and degree of crystallization. The catalytic efficiencies of the catalysts, which were prepared with various methods, were tested and compared by a fixed test bed and simulated flue gas. Sintering temperature had important influences on the microstructures and catalytic efficiencies of the catalysts. The catalyst for sintering at 450\u00b0C had complete crystallization and stable microstructure, the catalytic efficiency of which reached 89%. And the active substances were well dispersed into the anatase phase TiO",
        "keywords": [
            "Catalytic efficiency",
            "Mercury porosimetry",
            "NOx",
            "Selective catalytic reduction",
            "X-ray diffractometer"
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2012,
        "id": "mGApZ7XZ"
    },
    "gwc3eZsn": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "Bussiness administration post doctor research station, Shandong University"
            },
            {
                "name": "Chenchen Liu",
                "org": "Information and Engineer College, Jining Medical University"
            }
        ],
        "title": "Attitude index group decision-making method of performance evaluation for coal enterprises energy conservation and reduction of pollutant emissions",
        "abstract": "For the performance evaluation of coal enterprises energy conservation and reduction of pollutant emission, a new attitude index group decision-making method is proposed based on trapezoidal fuzzy numbers. Under the condition in which the information of attributes weights and decision maker weights is entirely, the attitude index is introduced firstly. By solving the fuzzy object programming for the entirely information, the weights of the attitude and decision making matrix are determined. Secondly, the value of group risk attitude is got by integrating the attitude index of the decision makers, and the group comprehensive attribute values of each alternative and the priorities are achieved. At last, the practical example of performance evaluation for coal enterprises energy conservation and reduction of pollutant emission shows the feasibility and effectiveness of the proposed method. \u00a9 2005 - 2012 JATIT & LLS. All rights reserved.",
        "keywords": [
            "Attitude index",
            "Energy conservation and reduction of pollutant emission",
            "Trapezoidal fuzzy number"
        ],
        "venue": "Journal of Theoretical and Applied Information Technology",
        "year": 2012,
        "id": "gwc3eZsn"
    },
    "5lc7qYkh": {
        "authors": [
            {
                "name": "Chenchen Liu",
                "org": ""
            },
            {
                "name": "Yan Gao",
                "org": ""
            },
            {
                "name": "Zhuyan Shao",
                "org": ""
            }
        ],
        "title": "Energy demand forecast based on the new weakening buffer operators with exponential type",
        "abstract": "Under the axiomatic system of buffer operator in grey system theory , a new class of weakening buffer operators with exponential type are established, which have the universality and practicability. The problem that there are some contradictions between quantitative analysis and qualitative analysis in pretreatment for vibration data sequences is resolved effectively. Finally, this paper gives the forecast of China energy demand in a short period by using the new weakening buffer operators. The conclusion shows the new weakening buffer operators increase the forecast precision of the data forecast model remarkable. \u00a9 2011 Published by Elsevier Ltd.",
        "keywords": [
            "Buffer operation",
            "Energy demand",
            "Weakening buffer operation"
        ],
        "venue": "Energy Procedia",
        "year": 2011,
        "id": "5lc7qYkh"
    },
    "76JFSQAC": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "School of Information"
            },
            {
                "name": "Yan Gao",
                "org": "Business School"
            },
            {
                "name": "Zun-Quan Xia",
                "org": "School of Mathematical Sciences"
            }
        ],
        "title": "Determining the discriminating domain of pursuit-evasion games",
        "abstract": "The pursuit-evasion games with two players and one target for an affine nonlinear control system were investigated. The problem of determining the discriminating domain in the region with inequality constraints for this class of control system was solved and a necessary and sufficient condition was given out. Based on viability theory and nonsmooth analysis method, a theorem of determining the discriminating domain for the nonlinear system was obtained, so that the problem can be transformed into the problem of determining the consistency of convex inequalities. Then a projection algorithm for solving the problem was provided based on the algorithm of convex feasible problem. The convergence theorem of the algorithm was received and finally the alternative theorem for pursuit-evasion games with two players was achieved.",
        "keywords": [
            "Affine nonlinear system",
            "Differential games",
            "Nonsmooth analysis",
            "Projection algorithm",
            "Pursuit-evasion games"
        ],
        "venue": "Shanghai Ligong Daxue Xuebao/Journal of University of Shanghai for Science and Technology",
        "year": 2012,
        "id": "76JFSQAC"
    },
    "O4cRPDgx": {
        "authors": [
            {
                "name": "Lihua Li",
                "org": "School of Mathematics and Physics"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Gexia Wang",
                "org": "School of Mathematics and Physics"
            }
        ],
        "title": "Necessary optimality conditions for a class of impulsive and switching systems",
        "abstract": "An optimal control problem for a class of hybrid impulsive and switching systems is considered. By defining switching times as part of extended state, we get the necessary optimality conditions for this problem. It is shown that the adjoint variables satisfy certain jump conditions and the Hamiltonian are continuous at switching instants. In addition, necessary optimality conditions of Fr\u00e9chet subdifferential form are presented in this paper. \u00a9 2012 Lihua Li et al.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Applied Mathematics",
        "year": 2012,
        "id": "O4cRPDgx"
    },
    "PWcpe3dY": {
        "authors": [
            {
                "name": "Li-Hua Li",
                "org": "School of Mathematics and Physics"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Jian-Fang Yang",
                "org": "School of Management"
            }
        ],
        "title": "Optimal control of a class of hybrid systems",
        "abstract": "An optimal control problem is investigated for a class of hybrid systems, where the impulsive instants are state-dependent. Instead of relying on the usual technique of variational approach, necessary optimality conditions of this hybrid system are obtained by parameterizing the impulsive instants. Then, the optimal control problem is transformed to a boundary value problem, which can be solved by numerical method or analytic method. Moreover, taking advantage of the theory of generalized differential, necessary optimality conditions are extended to Frechet differential form. It is shown that, at the continuous part of this hybrid dynamic system, the necessary optimality conditions have the same form as traditional continuous system. At the impulsive points of this system, the Hamiltonian function is continuous and the adjoint variable satisfies certain condition. Finally, two examples are presented to illustrate validity of the methods.",
        "keywords": [
            "Frechet differential",
            "Hybrid system",
            "Necessary optimality condition",
            "Optimal control"
        ],
        "venue": "Kongzhi Lilun Yu Yingyong/Control Theory and Applications",
        "year": 2013,
        "id": "PWcpe3dY"
    },
    "hYfPyvEG": {
        "authors": [
            {
                "name": "Chenchen Liu",
                "org": "Information and Engineer College"
            },
            {
                "name": "Li Li",
                "org": "Information and Engineer College"
            },
            {
                "name": "Yan Gao",
                "org": "College of Economics and Management"
            }
        ],
        "title": "Analysis of the relationship between the influential factors of regional FEEEP coordinated growth based on the DEMATEL method",
        "abstract": "According to the characteristics of regional FEEEP coordinated growth, the influential factors index system of regional FEEEP coordinated growth is constructed. Using the DEMATEL method, the interactions among factors are analyzed, and the most important factors of regional FEEEP coordinated growth are found. \u00a9 (2011) Trans Tech Publications.",
        "keywords": [
            "DEMATEL method",
            "FEEEP system",
            "Influential factors"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2011,
        "id": "hYfPyvEG"
    },
    "yU2Wnoc6": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "John Lygeros",
                "org": "Department of Electrical and Computer Engineering"
            }
        ],
        "title": "On the computation of viable polytopes for linear systems",
        "abstract": "We develop a procedure for computing viable (also known as controlled invariant) polytopes of a given subset of the state space under linear dynamics. The advantage of the proposed algorithm is that at every step it maintains a polytope that is itself viable. Therefore, even if the algorithm is stopped before termination it will still return a viable polytope, that can be subsequently used for controller design.",
        "keywords": [
            "Invariance",
            "Linear system",
            "Optimization",
            "Polytope"
        ],
        "venue": "European Control Conference, ECC 2003",
        "year": 2003,
        "id": "yU2Wnoc6"
    },
    "gaa8MxWG": {
        "authors": [
            {
                "name": "Yan Gao",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao Luan",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Kai Cheng",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Tao L\u00fc",
                "org": "School of Energy and Power Engineering"
            },
            {
                "name": "Yanjuan Zheng",
                "org": "School of Energy and Power Engineering"
            }
        ],
        "title": "Industrial experiment on selective catalytic reduction honeycomb catalyst",
        "abstract": "The selective catalytic reduction selective catalytic reduction (SCR) honeycomb catalysts were prepared with industrial grade chemicals. The NO ",
        "keywords": [
            "Honeycomb catalysts",
            "Industrial flue gas",
            "Influencing factor",
            "Selective catalytic reduction (SCR)",
            "V 2O 5-WO 3- MoO 3/TiO 2"
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2011,
        "id": "gaa8MxWG"
    },
    "4r7p5FRF": {
        "authors": [
            {
                "name": "Ying Liu",
                "org": "Department of Stomatology"
            },
            {
                "name": "Jie Gao",
                "org": "Department of Stomatology"
            },
            {
                "name": "Yan Gao",
                "org": "Center of Oral Implantology"
            },
            {
                "name": "Shuaimei Xu",
                "org": "Department of Stomatology"
            },
            {
                "name": "Xueling Zhan",
                "org": "Department of Stomatology"
            },
            {
                "name": "Buling Wu",
                "org": "Department of Stomatology"
            }
        ],
        "title": "In vitro study of dentin hypersensitivity treated by 980-nm diode laser",
        "abstract": "Introduction: To investigate the ultrastructural changes of dentin irradiated with 980-nm diode laser under different parameters and to observe the morphological alterations of odontoblasts and pulp tissue to determine the safety parameters of 980-nm diode laser in the treatment of dentin hypersensitivity (DH). Methods: Twenty extracted human third molars were selected to prepare dentin discs. Each dentin disc was divided into four areas and was irradiated by 980-nm diode laser under different parameters: Group A: control group, 0 J/cm!",
        "keywords": [
            "Dentin sensitivity",
            "Lasers",
            "Scanning electron microscopy"
        ],
        "venue": "Journal of Lasers in Medical Sciences",
        "year": 2013,
        "id": "4r7p5FRF"
    },
    "TPqHhOWr": {
        "authors": [
            {
                "name": "Ya-Zheng Dang",
                "org": "School of Mathematics and Information Science"
            },
            {
                "name": "Yan Gao",
                "org": "Business School"
            }
        ],
        "title": "Incomplete projection algorithm for solving a system of convex inequalities in a product space",
        "abstract": "A parallel incomplete projection method with variable weights and under relaxation coefficient was proposed for the system of convex inequalities. Then, the parallel incomplete projection method was transformed in a given Euclidean space into a semi-sequential incomplete projection method in a product space by constructing a new space. Convergent results for the parallel incomplete projection methods may be obtained from the semi-sequential ones, which can simplify the proof of the convergence.",
        "keywords": [
            "Convergence analysis",
            "Convex inequalities system",
            "Incomplete projection algorithm",
            "Product space"
        ],
        "venue": "Shanghai Ligong Daxue Xuebao/Journal of University of Shanghai for Science and Technology",
        "year": 2012,
        "id": "TPqHhOWr"
    },
    "0zNJmeDn": {
        "authors": [
            {
                "name": "Ying Li",
                "org": "School of Mathematics Science"
            },
            {
                "name": "Yan Gao",
                "org": "School of Management"
            },
            {
                "name": "Wenbin Guo",
                "org": "School of Mathematics Science"
            }
        ],
        "title": "A Hermitian least squares solution of the matrix equation AXB = C subject to inequality restrictions",
        "abstract": "This paper gives some closed-form formulas for computing the maximal and minimal ranks and inertias of P-X with respect to X, where P\u2208CHn is given, and X is a Hermitian least squares solution to the matrix equation AXB=C. We derive, as applications, necessary and sufficient conditions for X(,>,<)P in the L\u00f6wner partial ordering. In addition, we give necessary and sufficient conditions for the existence of a Hermitian positive (negative, nonpositive, nonnegative) definite least squares solution to AXB=C. \u00a9 2012 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "Generalized inverse",
            "Hermitian solution",
            "Inertia",
            "Least squares solution",
            "Matrix equation",
            "Rank"
        ],
        "venue": "Computers and Mathematics with Applications",
        "year": 2012,
        "id": "0zNJmeDn"
    },
    "LoxlNUnm": {
        "authors": [
            {
                "name": "Li Li",
                "org": "Business School"
            },
            {
                "name": "Yan Gao",
                "org": "Business School"
            }
        ],
        "title": "Approximate subgradient projection algorithm for convex feasibility problem",
        "abstract": "An \u03b5-subgradient projection algorithm for solving a convex feasibility problem is presented. Based on the iterative projection methods and the notion of \u03b5-subgradient, a series of special projection hyperplanes is established. Moreover, compared with the existing projection hyperplanes methods with subgradient, the proposed hyperplanes are interactive with \u03b5, and their ranges are more larger. The convergence of the proposed algorithm is given under some mild conditions, and the validity of the algorithm is proved by the numerical test.",
        "keywords": [
            "\u03b5-Subgradient",
            "Convex feasibility problem",
            "Projection algorithm"
        ],
        "venue": "Journal of Systems Engineering and Electronics",
        "year": 2010,
        "id": "LoxlNUnm"
    },
    "HcmJjsP1": {
        "authors": [
            {
                "name": "F. Liu",
                "org": "Harbin Institute of Technology"
            },
            {
                "name": "F. He",
                "org": "Harbin Institute of Technology"
            },
            {
                "name": "Y. Yao",
                "org": "Harbin Institute of Technology"
            }
        ],
        "title": "Linear matrix inequality-based robust H\u221e control of sampled-data systems with parametric uncertainties",
        "abstract": "The problem of robust H",
        "keywords": [
            ""
        ],
        "venue": "IET Control Theory and Applications",
        "year": 2008,
        "id": "HcmJjsP1"
    },
    "TVgkDetn": {
        "id": "TVgkDetn",
        "title": "Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca2+ leak by reducing oxidative modification of ryanodine receptors.",
        "abstract": "Our recent studies demonstrate that burn trauma induces leaky sarcoplasmic reticulum (SR) in heart due to excessively active ryanodine receptor (RyR) function. SR Ca(2+) leak causes partial depletion of SR Ca(2+) content and disturbances in intracellular Ca(2+) homeostasis, resulting in the pathogenesis of burn-generated cardiac dysfunction. This study investigated the role of polydatin, a resveratrol glucoside, in preventing SR leak and its therapeutic effect against burn-generated cardiac dysfunction. We found that polydatin treatment improved cardiac function impaired by burn injury of 30% of total body surface area. Parallel to the alterations in cardiac function, polydatin significantly increased the defective systolic Ca(2+) transient and contractility in burn-traumatized cardiomyocytes. Burn injury increased the occurrence of Ca(2+) sparks. The enhancement of Ca(2+) spark-mediated SR leak caused partial depletion of SR Ca(2+) content in burn-traumatized cardiomyocytes. Furthermore, we found that the content of free thiols (the number of reduced cysteines) in RyR2 in cardiomyocytes determined by the monobromobimane fluorescence of RyR2 was decreased markedly in burn-traumatized hearts. Polydatin treatment decreased intracellular reactive oxygen species levels and restored the amount of free thiols in RyR2 in burns. Concomitantly, polydatin corrected Ca(2+) spark-mediated SR leak and restored SR Ca(2+) load. The systolic Ca(2+) transient and cellular contractility were significantly increased by polydatin treatment. Taken together, the present findings provide the first evidence demonstrating that polydatin prevents enhanced Ca(2+) spark-mediated SR leak by reducing oxidative stress in RyR2 in burn-traumatized heart, leading to protection of cardiac function against burn injury.",
        "keywords": [
            "RAT VENTRICULAR MYOCYTES",
            "HEART-FAILURE",
            "THERMAL-INJURY",
            "CALCIUM-RELEASE",
            "TRAUMA",
            "CHANNEL",
            "DYSFUNCTION",
            "MECHANISM",
            "RABBITS",
            "SPARKS"
        ],
        "authors": [
            {
                "name": "Xin Jiang",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Wenjuan Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Jianxin Deng",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Liqin Lan",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Xiang Xue",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Cuicui Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Gaorui Cai",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Xinping Luo",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Jie Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Free radical biology & medicine",
        "year": 2013
    },
    "bC55l9Bg": {
        "id": "bC55l9Bg",
        "title": "Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca 2+ leak by reducing oxidative modification of ryanodine receptors",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xin jiang",
                "org": ""
            },
            {
                "name": "wenjuan liu",
                "org": ""
            },
            {
                "name": "jianxin deng",
                "org": ""
            },
            {
                "name": "liqin lan",
                "org": ""
            },
            {
                "name": "xiang xue",
                "org": ""
            },
            {
                "name": "cuicui zhang",
                "org": ""
            },
            {
                "name": "gaorui cai",
                "org": ""
            },
            {
                "name": "xinping luo",
                "org": ""
            },
            {
                "name": "jie liu",
                "org": ""
            }
        ],
        "venue": "Free Radical Biology and Medicine",
        "year": 2013
    },
    "t8KYnU7x": {
        "id": "t8KYnU7x",
        "title": "Functional role of TRPV4-KCa2.3 signaling in vascular endothelial cells in normal and streptozotocin-induced diabetic rats.",
        "abstract": "The small conductance and intermediate conductance Ca(2+)-activated K(+) channels are known to be involved in the endothelium-dependent hyperpolarization. Ca(2+) entry into endothelial cells stimulates these channels, causing membrane hyperpolarization in endothelial cells and underlying smooth muscle cells. In the present study, with the use of coimmunoprecipitation and double immunolabeling methods, we demonstrated a physical interaction of transient receptor potential vanilloid 4 (TRPV4) with K(Ca)2.3 in rat mesenteric artery endothelial cells. Acetylcholine and 4\u03b1-PDD mainly acted through TRPV4-K(Ca)2.3 pathway to induce smooth muscle hyperpolarization and vascular relaxation. K(Ca)3.1 was also involved in the process but at a much lesser degree than that of K(Ca)2.3. Stimulating TRPV4-K(Ca)2.3 signaling pathway also increased local blood flow in mesenteric beds and reduced systemic blood pressure in anesthetized rats. In streptozotocin-induced diabetic rats, the expression levels of TRPV4 and K(Ca)2.3 were reduced, which could be an underlying reason for the dysfunction of endothelium-dependent hyperpolarization in these animals. These results demonstrated an important physiological and pathological role of TRPV4-K(Ca)2.3 signaling pathway in vascular endothelial cells.",
        "keywords": [
            "endothelial cells",
            "trpv4-k ca2.3 association",
            "endothelium-derived hyperpolarizing factor",
            "vascular relaxation",
            "trpv4-kca2.3 association"
        ],
        "authors": [
            {
                "name": "Xin Ma",
                "org": "Jiangnan University(Jiangnan University),Wuxi,China"
            },
            {
                "name": "Juan Du",
                "org": "School of Biomedical Sciences(School of Biomedical Sciences),,China"
            },
            {
                "name": "Peng Zhang",
                "org": "School of Biomedical Sciences(School of Biomedical Sciences),,China"
            },
            {
                "name": "Jianxin Deng",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jie Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Francis Fu Yuen Lam",
                "org": "School of Biomedical Sciences(School of Biomedical Sciences),,China"
            },
            {
                "name": "Ronald A. Li",
                "org": "The University of Hong Kong(University of Hong Kong,The University of Hong Kong),Pokfulam,Hong Kong"
            },
            {
                "name": "Yu Huang",
                "org": "School of Biomedical Sciences(School of Biomedical Sciences),,China"
            },
            {
                "name": "Jian Jin",
                "org": "Jiangnan University(Jiangnan University),Wuxi,China"
            },
            {
                "name": "Xiaoqiang Yao",
                "org": "Jiangnan University(Jiangnan University),Wuxi,China"
            }
        ],
        "venue": "Hypertension",
        "year": 2013
    },
    "mZ4EUDX1": {
        "id": "mZ4EUDX1",
        "title": "Polydatin modulates Ca2+ handling, excitation-contraction coupling and \u03b2-adrenergic signaling in rat ventricular myocytes",
        "abstract": "Polydatin (PD), a resveratrol glucoside, has recently been suggested to have cardioprotective effects against heart diseases, including ischemia-reperfusion injury and pressure-overload induced ventricular remodeling. However, the mechanisms are poorly understood. This study aims to investigate the direct effects of PD on cardiac Ca2+ handling and excitation-contraction (EC) coupling to explore the potential role of which in PD-mediated cardioprotection. We found that micromolar PD decreased action potential-elicited Ca2+ transient, but slightly increased cell shortening. The contradictory response could be attributed to PD increasing myofilament Ca2+ sensitivity. Exploring the activities of the two types of Ca2+ channels, L-type Ca2+ channels (LCCs) and ryanodine receptors (RyRs), reveals that PD dose-dependently decreased LCC current (ICa), but increased frequency of spontaneous Ca2+ sparks, the elementary Ca2+ releasing events reflecting RyR activity in intact cells. PD dose-dependently increased the gain of EC coupling. In contrast, PD dose-dependently decreased SR Ca2+ content. Furthermore, PD remarkably negated \u03b2-adrenergic receptor (AR) stimulation-induced enhancement of ICa and Ca2+ transients, but did not inhibit \u03b2-AR-mediated inotropic effect. Inhibition of nitric oxide synthase (NOS) with L-NAME abolished PD regulation of ICa and Ca2+ spark rate, and significantly inhibited the alteration of Ca2+ transient and myocyte contractility stimulated by PD. These results collectively indicate that PD modulated cardiac EC coupling mainly by inversely regulating LCC and RyR activity and increasing myofilament Ca2+ sensitivity through increasing intracrine NO, resulting in suppression of Ca2+ transient without compromising cardiac contractility. The unique regulation of PD on cardiac EC coupling and responsiveness to \u03b2-AR signaling implicates that PD has potential cardioprotective effects against Ca2+ mishandling related heart diseases. \u00a9 2012 Elsevier Ltd.",
        "keywords": [
            "\u03b2-Adrenergic signaling",
            "Ca2+ signaling",
            "Cardiac myocyte",
            "Excitation-contraction coupling",
            "NO",
            "PD",
            "Polydatin"
        ],
        "authors": [
            {
                "name": "Jianxin Deng",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Wenjuan Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Yanru Wang",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Ming Dong",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Ming Zheng",
                "org": "Peking University(Peking University),Beijing,China"
            },
            {
                "name": "Jie Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Journal of Molecular and Cellular Cardiology",
        "year": 2012
    },
    "OlioeKKN": {
        "id": "OlioeKKN",
        "title": "Cellular mechanism underlying burn serumygenerated bidirectional regulation of excitation-contraction coupling in isolated rat cardiomyocytes",
        "abstract": "Myocardial depressant factors have long been recognized to be present in burn serum (BS) and contribute to burn-generated cardiac contractile dysfunction. However, much of the cellular and molecular mechanism for its role in the development of the cardiac deficiency remains unknown. In this study, we investigated the effect of BS on myocardial contractility and Ca2+ handling in single rat cardiomyocytes. The results revealed that BS (5% by volume) bidirectionally regulated cardiac excitation-contraction (EC) coupling. The action potential-elicited Ca2+ transient and cell shortening were increased by 28.0% \u00b1 9.7% and 34.7% \u00b1 12.5% within 20 min after BS stimulation (the upregulation phase), but decreased by 20.5% \u00b1 6.8% and 32.3% \u00b1 5.1% at 60 min after BS stimulation (the downregulation phase). There was a 32.0% \u00b1 5.8% reduction in sarcoplasmic reticulum (SR) Ca2+ content at the downregulation phase, whereas no alteration was detected at the upregulation phase. The incidences of spontaneous Ca 2+ sparks and Ca2+ waves were significantly increased after BS stimulation, no matter at the upregulation or downregulation phase. The hyperactive Ca2+ sparks and Ca2+ waves could be completely abolished by antioxidative treatment (vitamin A, 0.2 mM; and vitamin E, 1 mM) and partially reversed by NOS inhibitor L-NAME (100 \u03bcM), but not by blocking Ca2+ influx with nifedipine (1 \u03bcM). With the normalization of Ca2+ sparks, BS-induced alterations of action potential-elicited Ca2+ transient and contractility were prevented by antioxidative therapy. Taken together, we propose that BS-associated bidirectional regulation of EC coupling is attributed largely to oxidative stress-induced hyperactivity of ryanodine receptors, increasing EC coupling through enhancing intracellular Ca2+ release initially, but subsequently decreasing EC coupling by partially depleting SR Ca2+ content through enhancement of Ca2+ spark-mediated SR leak. Copyright \u00a9 2011 by the Shock Society.",
        "keywords": [
            "Burn injury",
            "Ca 2+ waves",
            "Ca2+ sparks",
            "Cardiomyocytes",
            "Excitation-contraction coupling",
            "Intracellular Ca2+ transient",
            "Reactive oxygen species",
            "Sarcoplasmic reticulum"
        ],
        "authors": [
            {
                "name": "Xinping Luo",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            },
            {
                "name": "Jianxin Deng",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Na Liu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Cuicui Zhang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Qiaobing Huang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jie Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Shock",
        "year": 2011
    },
    "pAjFniCk": {
        "id": "pAjFniCk",
        "title": "High-mobility group box 1 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins.",
        "abstract": "Transient outward potassium currents (I(to)) are major early repolarization currents in shaping cardiac action potential (AP). Downregulation of I(to) contributes to AP configuration alteration in myocardial infarction (MI) and numerous other heart diseases. High-mobility group box 1 (HMGB1), a proinflammatory cytokine, has been reported to increase dramatically in the serum of patients with MI, participating in ischemia-reperfusion injury and recovery of post-infarction failing heart. This study investigated the possible role of HMGB1 in regulating cardiac I(to) and electrical stability. HMGB1 treatment for 24h significantly inhibited the current densities of heterologously expressed Kv4.3 and Kv4.2 in COS-7 cells and native I(to) in neonatal rat ventricular myocytes (NRVMs) in a dose-dependent manner. HMGB1 decreased the mRNA and protein levels of the I(to) alpha subunits Kv4.2 and Kv4.3 channels, but not the beta subunit KChIP2 and KCNE2 in NRVMs. The receptor binding domain (150-186 amino acid residues) responsible for receptor of advanced glycation end product (RAGE) binding similarly inhibited I(to)(,) while treatment with soluble RAGE that blocks binding of ligands to cell-surface RAGE partially restored I(to) current density and Kv4 protein expressions. Box A which possesses no proinflammatory activity of HMGB1 still remained part of the I(to) suppression effect. In addition to downregulating I(to), HMGB1 modestly inhibited L-type Ca(2+) current, but not I(K1). The AP duration (APD) was slightly prolonged by HMGB1 treatment. These results collectively establish HMGB1 as a novel pathological factor downregulating I(to) partially through HMGB1-RAGE interaction, providing new insights into the potential molecular mechanisms underlying the electrical remodeling in MI.",
        "keywords": [
            "transient outward current",
            "high-mobility group box 1",
            "receptor of advanced glycation end product",
            "kv4",
            "action potential",
            "proinflammatory cytokine",
            "current density",
            "heterologous expression",
            "protein expression",
            "amino acid",
            "myocardial infarct",
            "molecular mechanics"
        ],
        "authors": [
            {
                "name": "Wenjuan Liu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jianxin Deng",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jia Xu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "HaiTang Wang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Meichun Yuan",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Na Liu",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Yong Jiang",
                "org": "Southern Medical University(^ Southern Medical University),TongHe,China"
            },
            {
                "name": "Jie Liu",
                "org": "Shenzhen University(Shenzhen University),Qingshuihe, Shenzhen,China"
            }
        ],
        "venue": "Journal of molecular and cellular cardiology",
        "year": 2010
    },
    "wVqvlGzI": {
        "id": "wVqvlGzI",
        "title": "High-mobility group box\u00a01 (HMGB1) downregulates cardiac transient outward potassium current (Ito) through downregulation of Kv4.2 and Kv4.3 channel transcripts and proteins",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Wenjuan Liu",
                "org": ""
            },
            {
                "name": "Jianxin Deng",
                "org": ""
            },
            {
                "name": "Jia Xu",
                "org": "Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China"
            },
            {
                "name": "Haitang Wang",
                "org": "Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China"
            },
            {
                "name": "Meichun Yuan",
                "org": "Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China"
            },
            {
                "name": "Na Liu",
                "org": "Department of Pathophysiology, Southern Medical University, Guangzhou 510515, China"
            },
            {
                "name": "Yong Jiang",
                "org": ""
            },
            {
                "name": "Jie Liu",
                "org": ""
            }
        ],
        "venue": "Journal of Molecular and Cellular Cardiology",
        "year": 2010
    },
    "Mp9UmgDK": {
        "authors": [
            {
                "name": "Wei Guo",
                "org": ""
            },
            {
                "name": "Hong Xu",
                "org": ""
            },
            {
                "name": "Wen-Yan Huang",
                "org": ""
            },
            {
                "name": "Jing Chen",
                "org": ""
            },
            {
                "name": "Yong Yang",
                "org": ""
            },
            {
                "name": "Rui Fu",
                "org": ""
            },
            {
                "name": "Hai-Mei Liu",
                "org": ""
            },
            {
                "name": "Xi-Liang Zha",
                "org": ""
            },
            {
                "name": "Zhi-Gang Zhang",
                "org": ""
            }
        ],
        "title": "Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-\u03b21",
        "abstract": "Objective: To illuminate the possible role of Prohibitin (PHB) in tubulointerstitial fibrosis. Methods: (1) Forty-eight renal biopsy specimens were obtained from the patients with various primary glomerulonephritis, 26 male and 22 female, aged 7.5 \u00b1 5.5 (2.5-13 years), and nine kidney tissue specimens were obtained form the tissues far away from the tumor tissues and confirmed by pathological examination as normal tissues in the kidney dissected during operation as normal control. Immunohistochemistry was used to detect the protein expression of PHB and \u03b1-smooth muscle actin (\u03b1-SMA). The correlation between PHB and degree of tubulointerstitial lesion was compared. (2) Rat kidney fibroblastoma cells of the line NRK-49F were cultured, and laser scanning confocal microscopy was used to observe the subcellular location of PHB protein. The changes of PHB protein and mRNA expression in the NRK-49F cells upon TGF-\u03b21 stimulation were detected by Western blotting and RT-PCR analysis. (3) PHB expression plasmid was constructed and transfected into the NRK-49F cells. Then, cell cycle analysis was performed by flow cytometry, and Western blotting and RT-PCR were performed to detect the PHB and \u03b1-SMA protein and mRNA expression in the NRK-49F cells treated with or without TGF-\u03b21. Results: (1) PHB protein expression was found in the normal renal tissues by immunohistochemistry, with a positive distribution in the interstitial cells and tubular epithelial cells. PHB was strongly down-regulated in the damaged interstitial and tubular epithelial cells, the higher the grade of damage, the lower the expression of PHB (all P < 0.01), and the PHB expression amount was negatively correlated with the degree of tubulointerstitial lesions (r = -0.802, P < 0.01). (2) Confocal microscopy showed that PHB was mainly located in the cytoplasm and weakly expressed in the nucleus of the NRK-49F cells. Treated with TGF-\u03b21, the PHB protein expression and mRNA expression in the NRK-49F cells were decreased both time-dependently and dose-dependently (all P <0. 01). (3) A recombinant pcDNA3. 1 (-)/PHB plasmid was successfully constructed. PHB protein expression in the transfected NRK-49F cells was 2.54 times higher compared with the non-transfected cells. (4) The proportions of the cells in the S and G",
        "keywords": [
            "Fibroblasts",
            "Phenotypic",
            "Prohibitin",
            "Transforming growth factor beta"
        ],
        "venue": "National Medical Journal of China",
        "year": 2007,
        "id": "Mp9UmgDK"
    },
    "aW6LZCEi": {
        "authors": [
            {
                "name": "Jian Chen",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Libo Yang",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Ju Gu",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Xiaoya Bai",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Yongbin Ren",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Tingting Fan",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Yi Han",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Li Jiang",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Fangming Xiao",
                "org": "Department of Plant, Soil, and Entomological Sciences, University of Idaho"
            },
            {
                "name": "Yongsheng Liu",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            },
            {
                "name": "Shuqing Cao",
                "org": "School of Biotechnology and Food Engineering, Hefei University of Technology"
            }
        ],
        "title": "MAN3 gene regulates cadmium tolerance through the glutathione-dependent pathway in Arabidopsis thaliana",
        "abstract": "Summary: Pollution of soil by the heavy metal cadmium (Cd) is a global environmental problem. The glutathione (GSH)-dependent phytochelatin (PC) synthesis pathway is one of the most important mechanisms contributing to Cd accumulation and tolerance. However, the regulation of this pathway is poorly understood. Here, we identified an Arabidopsis thaliana cadmium-tolerant dominant mutant xcd1-D (XVE system-induced cadmium-tolerance 1) and cloned XCD1 gene (previously called MAN3), which encodes an endo-\u03b2-mannanase. Overexpression of MAN3 led to enhanced Cd accumulation and tolerance, whereas loss-of-function of MAN3 resulted in decreased Cd accumulation and tolerance. In the presence of estradiol, enhanced Cd accumulation and tolerance in xcd1-D was associated with GSH-dependent, Cd-activated synthesis of PCs, which was correlated with coordinated activation of gene expression. Cd stress-induced expression of MAN3 and the consequently increased mannanase activity, led to increased mannose content in cell walls. Moreover, mannose treatment not only rescued the Cd-sensitive phenotype of the xcd1-2 mutant, but also improved the Cd tolerance of wild-type plants. Significantly, this mannose-mediated Cd accumulation and tolerance is dependent on GSH-dependent PC concentrations via coordinated control of expression of genes involved in PC synthesis. Our results suggest that MAN3 regulates the GSH-dependent PC synthesis pathway that contributes to Cd accumulation and tolerance in A. thaliana by coordinated control of gene expression.",
        "keywords": [
            "Arabidopsis thaliana",
            "Cadmium (Cd) tolerance",
            "Glutathione",
            "MAN3",
            "Mannose",
            "Phytochelatins"
        ],
        "venue": "New Phytologist",
        "year": 2015,
        "id": "aW6LZCEi"
    },
    "uUxPYng1": {
        "authors": [
            {
                "name": "Jinli Pei",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            },
            {
                "name": "Huijun Wang",
                "org": "Qiongzhou University"
            },
            {
                "name": "Zhiqiang Xia",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            },
            {
                "name": "Chen Liu",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            },
            {
                "name": "Xin Chen",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            },
            {
                "name": "Pingan Ma",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            },
            {
                "name": "Cheng Lu",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            },
            {
                "name": "Wenquan Wang",
                "org": "The Institute of Tropical Bioscience and Biotechnology"
            }
        ],
        "title": "Phylogeny and expression pattern of starch branching enzyme family genes in cassava (Manihot esculenta Crantz) under diverse environments",
        "abstract": "Starch branching enzyme (SBE) is one of the key enzymes involved in starch biosynthetic metabolism. In this study, six SBE family genes were identified from the cassava genome. Phylogenetic analysis divided the MeSBE family genes into dicot family A, B, C, and the new group. Tissue-specific analysis showed that MeSBE2.2 was strongly expressed in leaves, stems cortex, and root stele, and MeSBE3 had high expression levels in stem cortex and root stele of plants in the rapid growth stage under field condition, whereas the expression levels of MeSBE2.1, MeSBE4, and MeSBE5 were low except for in stems cortex. The transcriptional activity of MeSBE2.2 and MeSBE3 was higher compared with other members and gradually increased in the storage roots during root growth process, while the other MeSBE members normally remained low expression levels. Expression of MeSBE2.2 could be induced by salt, drought, exogenous abscisic acid, jasmonic acid, and salicylic acid signals, while MeSBE3 had positive response to drought, salt, exogenous abscisic acid, and salicylic acid in leaves but not in storage root, indicating that they might be more important in starch biosynthesis pathway under diverse environments.",
        "keywords": [
            "Abiotic stress treatment",
            "Cassava",
            "Differential expression analysis",
            "Phylogenetic analysis",
            "Promoter analysis",
            "Starch branching enzyme"
        ],
        "venue": "Molecular and Cellular Biochemistry",
        "year": 2015,
        "id": "uUxPYng1"
    },
    "yNJRuscq": {
        "authors": [
            {
                "name": "Jinli Pei",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            },
            {
                "name": "Huijun Wang",
                "org": "Qiongzhou University"
            },
            {
                "name": "Zhiqiang Xia",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            },
            {
                "name": "Chen Liu",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            },
            {
                "name": "Xin Chen",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            },
            {
                "name": "Pingan Ma",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            },
            {
                "name": "Cheng Lu",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            },
            {
                "name": "Wenquan Wang",
                "org": "The Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture"
            }
        ],
        "title": "Phylogeny and expression pattern of starch branching enzyme family genes in cassava (Manihot esculenta Crantz) under diverse environments",
        "abstract": "Starch branching enzyme (SBE) is one of the key enzymes involved in starch biosynthetic metabolism. In this study, six SBE family genes were identified from the cassava genome. Phylogenetic analysis divided the MeSBE family genes into dicot family A, B, C, and the new group. Tissue-specific analysis showed that MeSBE2.2 was strongly expressed in leaves, stems cortex, and root stele, and MeSBE3 had high expression levels in stem cortex and root stele of plants in the rapid growth stage under field condition, whereas the expression levels of MeSBE2.1, MeSBE4, and MeSBE5 were low except for in stems cortex. The transcriptional activity of MeSBE2.2 and MeSBE3 was higher compared with other members and gradually increased in the storage roots during root growth process, while the other MeSBE members normally remained low expression levels. Expression of MeSBE2.2 could be induced by salt, drought, exogenous abscisic acid, jasmonic acid, and salicylic acid signals, while MeSBE3 had positive response to drought, salt, exogenous abscisic acid, and salicylic acid in leaves but not in storage root, indicating that they might be more important in starch biosynthesis pathway under diverse environments.",
        "keywords": [
            "Abiotic stress treatment",
            "Cassava",
            "Differential expression analysis",
            "Phylogenetic analysis",
            "Promoter analysis",
            "Starch branching enzyme"
        ],
        "venue": "Molecular and Cellular Biochemistry",
        "year": 2015,
        "id": "yNJRuscq"
    },
    "3oS1MMUx": {
        "id": "3oS1MMUx",
        "title": "The Application Research Of Sondex Corrosion Logging Technology In The ChangQing Oilfield",
        "authors": [
            {
                "name": "Xie Ping",
                "org": ",Chag Yi"
            },
            {
                "name": "Chen Lei",
                "org": ",Chag Yi"
            }
        ],
        "venue": "instrumentation analysis monitoring",
        "keywords": [],
        "year": 2009
    },
    "4QFHs4WY": {
        "id": "4QFHs4WY",
        "title": "Discuss on Shortage of Conducting Build-up Pressure Testing by Testing Track",
        "authors": [
            {
                "name": "Chen Lei",
                "org": "Downhole Technical Operation Company, Changqing Petroleum Exploration Bureau"
            }
        ],
        "venue": "well testing",
        "keywords": [
            "buildup pressure curve",
            "low permeability reservoir",
            "evaluation"
        ],
        "year": 2008
    },
    "ERBoYmxA": {
        "id": "ERBoYmxA",
        "title": "Changing valve through fishable pipe bridge plug without killing well",
        "authors": [
            {
                "name": "Tian Yuchen",
                "org": "Changqing Downhole Technology and Operation Company, Sichuan-Changqing Drilling Company, CNPC, Xianyang , China"
            },
            {
                "name": "Xie Ping",
                "org": "Changqing Downhole Technology and Operation Company, Sichuan-Changqing Drilling Company, CNPC, Xianyang , China"
            },
            {
                "name": "Chen Lei",
                "org": "Changqing Downhole Technology and Operation Company, Sichuan-Changqing Drilling Company, CNPC, Xianyang , China"
            },
            {
                "name": "Lei Yongli",
                "org": "Changqing Downhole Technology and Operation Company, Sichuan-Changqing Drilling Company, CNPC, Xianyang , China"
            },
            {
                "name": "Gao Hongping",
                "org": "Changqing Downhole Technology and Operation Company, Sichuan-Changqing Drilling Company, CNPC, Xianyang , China"
            }
        ],
        "venue": "fault-block oil & gas field",
        "keywords": [
            "fishable pipe bridge plug",
            "valve",
            "changing valve without killing the well",
            "field test"
        ],
        "year": 2009
    },
    "RiPqfoqc": {
        "id": "RiPqfoqc",
        "title": "Discuss on Well Test Technology for Shallow Gas of Changqing Oilfield",
        "authors": [
            {
                "name": "Chen Lei",
                "org": "Down Hole Operation Company,Chuanqing Drilling & Exploration Co.,Ltd"
            },
            {
                "name": "Gao Jinhong",
                "org": "Down Hole Operation Company,Chuanqing Drilling & Exploration Co.,Ltd"
            },
            {
                "name": "Ji Dongdong",
                "org": "Down Hole Operation Company,Chuanqing Drilling & Exploration Co.,Ltd"
            }
        ],
        "venue": "well testing",
        "keywords": [
            "conventional formation test",
            "test tech expand",
            "shallow gas"
        ],
        "year": 2012
    },
    "eujkMnqJ": {
        "id": "eujkMnqJ",
        "title": "A Brief Analysis for Application of Technology about Stuck Freeing and Fishing by Blanking Hammer in Yu43-9 Well",
        "authors": [
            {
                "name": "Chen Lei",
                "org": "Down-Hole Technical Operation Department,Chuanqing Drilling and Exploration Engineering Co.,Ltd"
            },
            {
                "name": "Tian Yuchen",
                "org": "Down-Hole Technical Operation Department,Chuanqing Drilling and Exploration Engineering Co.,Ltd"
            },
            {
                "name": "Cai Gaoxian",
                "org": "Down-Hole Technical Operation Department,Chuanqing Drilling and Exploration Engineering Co.,Ltd"
            }
        ],
        "venue": "well testing",
        "keywords": [
            "risk",
            "application",
            "safety",
            "fishing",
            "analysis",
            "blanking hammer"
        ],
        "year": 2008
    },
    "nrKi31LJ": {
        "id": "nrKi31LJ",
        "title": "APPLICATION AND STUDY ON SONDEX CORROSION LOGGING TECHNOLOGY IN CHANGQING OIL FIELD",
        "authors": [
            {
                "name": "CHEN Lei",
                "org": "CCDC Downhole Service Company"
            }
        ],
        "venue": "drilling & production technology",
        "keywords": [
            "corrosion well logging",
            "application",
            "problems",
            "data interpretation",
            "imaging"
        ],
        "year": 2010
    },
    "TOZd5VEL": {
        "id": "TOZd5VEL",
        "title": "Application of Compound Fracture Technology in Changqing Oilfield with Three Being Low",
        "authors": [
            {
                "name": "Chen Lei",
                "org": "Downhole Technical Operation Team,Changqing Petroleum Exploration Bureau"
            },
            {
                "name": "Chang Yi",
                "org": "Downhole Technical Operation Team,Changqing Petroleum Exploration Bureau"
            },
            {
                "name": "Gao Jinhong",
                "org": "Downhole Technical Operation Team,Changqing Petroleum Exploration Bureau"
            }
        ],
        "venue": "well testing",
        "keywords": [
            "stimulating effect",
            "reservoir with \"three being low\"",
            "compound fracture",
            "Changqing oilfield"
        ],
        "year": 2008
    },
    "Uhjy1vCZ": {
        "id": "Uhjy1vCZ",
        "title": "Application of compound fracturing technology in oil reservoir with low porosity, permeability and productivity of Changqing Oilfield",
        "authors": [
            {
                "name": "Chen Lei",
                "org": "."
            },
            {
                "name": "Chang Yi",
                "org": "."
            },
            {
                "name": "Gao Jinhong",
                "org": "."
            }
        ],
        "venue": "fault-block oil & gas field",
        "keywords": [
            "compound fracturing",
            "oil reservoir with low porosity",
            "Changqing Oilfield",
            "permeability and productivity.",
            "effect of increasing production"
        ],
        "year": 2008
    },
    "hkSBl0pU": {
        "id": "hkSBl0pU",
        "title": "The Design Of Tube Structure In Bias Manometer And Retrievable Technology",
        "authors": [
            {
                "name": "Xie Ping",
                "org": ",et al"
            },
            {
                "name": "Chen Lei",
                "org": ",et al"
            }
        ],
        "venue": "instrumentation analysis monitoring",
        "keywords": [],
        "year": 2009
    },
    "Y4Qg2Nm1": {
        "authors": [
            {
                "name": "Rui Ma",
                "org": "Hunan Key Laboratory of Smart Grids Operation and Control"
            },
            {
                "name": "Ren Kang",
                "org": "Tianshui Power Supply Company of Gansu Power Supply Company"
            },
            {
                "name": "Bin Luo",
                "org": "Hunan Key Laboratory of Smart Grids Operation and Control"
            },
            {
                "name": "Huiming Xu",
                "org": "State Grid Information and Telecommunication Co., Ltd."
            },
            {
                "name": "Jin He",
                "org": "China Resources Power (Changshu) Co., Ltd."
            }
        ],
        "title": "An improved principal component analysis based recognition method for energy consumption characteristics of thermal generation unit",
        "abstract": "The energy consumption characteristics of thermal generation unit, namely the characteristic relation among coal consumption rate for power generation and energy consumption parameters, reflects energy consumption feature of the unit, so it is an important part in the research on energy-saving of generation unit. Important information such as the energy consumption characteristics of generation unit is implied in operational data, thus theoretically the energy consumption characteristics of the unit can be attained by regression in data mining (DM) technique. However, various energy consumption indices of a unit and the multiple collinearities among them make the regression analysis difficult. A method to solve this problem is proposed: firstly, utilizing the functions of feature extraction and dimension reduction in principal component analysis (PCA) and at the cost of losing bits of information, the difficulty in the regression of energy consumption characteristic equation due to too high dimension of energy consumption variables and multiple correlativity among them is solved; then based on the energy consumption characteristic equation, sensitivity coefficients of important energy consumption indices are recognized; finally, the effectiveness of the proposed method is verified by analysis on energy consumption characteristics of an actual 600 MW unit of a certain thermal power plant in China.",
        "keywords": [
            "Energy consumption characteristics",
            "Feature extraction",
            "Improved principal component analysis",
            "Low-carbon electricity",
            "Sensitivity analysis"
        ],
        "venue": "Dianwang Jishu/Power System Technology",
        "year": 2013,
        "id": "Y4Qg2Nm1"
    },
    "4Ec0SWJ1": {
        "authors": [
            {
                "name": "Q. Wu",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Y. Liu",
                "org": "Beijing Institute of Hydrogeology and Engineering Geology"
            },
            {
                "name": "W. Zhou",
                "org": "ERT"
            },
            {
                "name": "X. Wu",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "S. Liu",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "W. Sun",
                "org": "China University of Mining and Technology"
            },
            {
                "name": "Y. Zeng",
                "org": "China University of Mining and Technology"
            }
        ],
        "title": "Assessment of water inrush vulnerability from overlying aquifer using GIS-AHP-based 'three maps-two predictions' method: A case study in Hulusu coal mine, China",
        "abstract": "The vulnerability of coal seams C2, C3 and C6 to water inrush from their overlying aquifers is evaluated in the first mining area of Hulusu coal mine. Detailed geological and hydrogeological data are collected for a hydrogeological conceptual model of water inrush. An index model of water abundance of the overlying aquifers is constructed using a geographic information system and the analytic hierarchy process, resulting in a zoning map of water abundance. Comparison of the numerically calculated height of the induced fracture zone above mining areas with the thickness of the overlying strata between the coal seam and the overlying aquifer leads to a connectivity map, which indicates whether the fracture zone is connected to the overlying aquifers. Superimposition of the two zoning maps leads to a comprehensive vulnerability zoning map of overlying aquifer water inrush. Visual Modflow is used to predict the mine discharges from the overlying aquifers under both natural and mining conditions. Appropriate prevention and control measures against overlying aquifer water inrush are proposed on the basis of the comprehensive vulnerability map.",
        "keywords": [
            ""
        ],
        "venue": "Quarterly Journal of Engineering Geology and Hydrogeology",
        "year": 2015,
        "id": "4Ec0SWJ1"
    },
    "8J7mLSr7": {
        "authors": [
            {
                "name": "Min Zhong",
                "org": "Key Laboratory of Dynamic Geodesy"
            },
            {
                "name": "Haoming Yan",
                "org": "Key Laboratory of Dynamic Geodesy"
            },
            {
                "name": "Xiaoping Wu",
                "org": "Jet Propulsion Laboratory"
            },
            {
                "name": "Jianbin Duan",
                "org": "Key Laboratory of Dynamic Geodesy"
            },
            {
                "name": "Yaozhong Zhu",
                "org": "Key Laboratory of Dynamic Geodesy"
            }
        ],
        "title": "Non-tidal oceanic contribution to polar wobble estimated from two oceanic assimilation data sets",
        "abstract": "Contributions of ocean bottom pressure and oceanic current to polar wobble are evaluated by using two oceanic data assimilation products. One product comes from Scripps Institution of Oceanography (ECCO), and the other is the Simple Ocean Data Assimilation (SODA) developed at University of Maryland. The results show that seasonal fluctuations in these two assimilated ocean angular momentum (OAM) time series agree better with each other along the Greenwich meridian than along the 90\u00b0E meridian. Furthermore, annual OAM change for ECCO is much closer to non-atmospheric residual, than that for SODA. However, annual OAM change for SODA along the Greenwich meridian compares better than that for ECCO to non-atmospheric-hydrologic residual, in which annual and semi-annual signals of land hydrologic angular momentum (LHAM) of a climate model are considered. At the meantime, annual LHAM signals along the 90\u00b0E meridian derived from the climate model and from the GRACE data are also compatible with each other. It is likely that ECCO overestimates the annual change along the 90\u00b0E meridian according to the angular momentum conservation law in the Earth system. Consequently, the oceanic role in polar wobble should be further examined. \u00a9 2005 Elsevier Ltd. All rights reserved.",
        "keywords": [
            "Earth rotation",
            "Oceanic angular momentum (OAM)",
            "Polar wobble"
        ],
        "venue": "Journal of Geodynamics",
        "year": 2006,
        "id": "8J7mLSr7"
    },
    "zNek4U4V": {
        "id": "zNek4U4V",
        "title": "ChemInform Abstract: A New Strategy for Facile Synthesis of Tetrasubstituted Pyridine Derivatives.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jun chen",
                "org": "zhejiang university"
            },
            {
                "name": "hangcheng ni",
                "org": "zhejiang university"
            },
            {
                "name": "wenteng chen",
                "org": "zhejiang university"
            },
            {
                "name": "guolin zhang",
                "org": "zhejiang university"
            },
            {
                "name": "yongping yu",
                "org": "zhejiang university"
            }
        ],
        "venue": "Cheminform",
        "year": 2014
    },
    "XSSwzrav": {
        "id": "XSSwzrav",
        "title": "ChemInform Abstract: Synthesis of Polysubstituted 5\u2010Aminopyrimidine\u20102(1H)\u2010thiones from Vinyl Azides and Thiourea.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhanying shao",
                "org": "zhejiang university"
            },
            {
                "name": "qinhai pan",
                "org": "zhejiang university"
            },
            {
                "name": "jun chen",
                "org": "zhejiang university"
            },
            {
                "name": "yongping yu",
                "org": "zhejiang university"
            },
            {
                "name": "guolin zhang",
                "org": "zhejiang university"
            }
        ],
        "venue": "Cheminform",
        "year": 2012
    },
    "9DUDhlbK": {
        "id": "9DUDhlbK",
        "title": "ChemInform Abstract: Synthesis and Cytotoxic Activities of 2\u2010(4\u2010(2\u2010Heterocycloethoxy)phenyl)\u20101,2,4\u2010triazolo[1,5\u2010a]pyridines.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guolin zhang",
                "org": "zhejiang university"
            },
            {
                "name": "jun chen",
                "org": "zhejiang university"
            }
        ],
        "venue": "Cheminform",
        "year": 2011
    },
    "rVYrAmK7": {
        "id": "rVYrAmK7",
        "title": "Synthesis and Cytotoxic Activities of 2-(4-(2-heterocycloethoxy)phenyl)- 1,2,4-triazolo[1,5-a] Pyridines",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "guolin zhang",
                "org": ""
            }
        ],
        "venue": "Letters in Organic Chemistry",
        "year": 2011
    },
    "Qm5Hzuqy": {
        "id": "Qm5Hzuqy",
        "title": "ChemInform Abstract: One\u2010Pot Synthesis of Disubstituted Imidazole Derivatives from \u03b1\u2010Azido Ketones Catalyzed by Potassium Ethylxanthate.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jun chen",
                "org": "zhejiang university"
            },
            {
                "name": "wenteng chen",
                "org": "zhejiang university"
            },
            {
                "name": "yongping yu",
                "org": "zhejiang university"
            },
            {
                "name": "guolin zhang",
                "org": "zhejiang university"
            }
        ],
        "venue": "Cheminform",
        "year": 2013
    },
    "TxDLj8IF": {
        "id": "TxDLj8IF",
        "title": "Synthesis of polysubstituted 5-aminopyrimidine-2(1 H )-thiones from vinyl azides and thiourea",
        "abstract": "",
        "keywords": [
            "mechanism"
        ],
        "authors": [
            {
                "name": "zhanying shao",
                "org": ""
            },
            {
                "name": "qinhai pan",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            },
            {
                "name": "yongping yu",
                "org": ""
            },
            {
                "name": "guolin zhang",
                "org": ""
            }
        ],
        "venue": "Tetrahedron",
        "year": 2012
    },
    "Ta0eYlbe": {
        "id": "Ta0eYlbe",
        "title": "ChemInform Abstract: Convenient Synthesis of Symmetrical Functionalized Biaryls from Aryl Halides Catalyzed by Palladium on Carbon.",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guolin zhang",
                "org": "zhejiang university"
            },
            {
                "name": "jun chen",
                "org": "zhejiang university"
            }
        ],
        "venue": "Cheminform",
        "year": 2011
    },
    "Xwl5Q7mr": {
        "id": "Xwl5Q7mr",
        "title": "Limitations of ozone data assimilation with adjustment of NO x emissions: mixed effects on NO 2 forecast over Beijing and surrounding areas",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "x tang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jin zhu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "z f wang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "a gbaguidi",
                "org": "aecom"
            },
            {
                "name": "c y lin",
                "org": "civil aviation administration of china"
            },
            {
                "name": "j y xin",
                "org": "chinese academy of sciences"
            },
            {
                "name": "tao song",
                "org": "chinese academy of sciences"
            },
            {
                "name": "bin hu",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Atmospheric Chemistry and Physics",
        "year": 2015
    },
    "2kqmRZE2": {
        "id": "2kqmRZE2",
        "title": "A Note on Self-gravitating Radiation in AdS Spacetime",
        "abstract": "",
        "keywords": [
            "space time",
            "anti de sitter",
            "de sitter space",
            "gravitational radiation",
            "quantum mechanics",
            "4 dimensional",
            "structural stability",
            "infinite series",
            "oscillations",
            "monotone function",
            "maximum entropy",
            "black hole"
        ],
        "authors": [
            {
                "name": "zhonghua li",
                "org": "chinese academy of sciences"
            },
            {
                "name": "bin hu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "ronggen cai",
                "org": "china west normal university"
            }
        ],
        "venue": "Physical Review D",
        "year": 2008
    },
    "pOknIBwN": {
        "id": "pOknIBwN",
        "title": "Co(II) and Ni(II) complexes incorporating N-acetimidoylacetamidine ligand: Synthesis and structures",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yanmei chen",
                "org": "soochow university"
            },
            {
                "name": "bin hu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "bin xu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "suyun zhang",
                "org": "soochow university"
            },
            {
                "name": "fengying zhou",
                "org": "soochow university"
            },
            {
                "name": "yahong li",
                "org": "soochow university"
            }
        ],
        "venue": "Russian Journal of Inorganic Chemistry",
        "year": 2012
    },
    "AfgT1GT9": {
        "id": "AfgT1GT9",
        "title": "Unique Axial Imidazole Geometries of Fully Halogenated Iron(II) Porphyrin Complexes: Crystal Structures and M\u00f6ssbauer Spectroscopic Studies.",
        "abstract": "The synthesis and characterization of several electron-poor iron(II) porphyrin (FeTFPPBr) complexes with axial imidazole ligands are reported. The single-crystal X-ray structures have been studied by a combination of crystal packing and Hirshfeld surface calculations, which explained the unusual axial-ligand geometries, e.g., the strong tilt of the Fe-N bonds and the imidazole planes. The six-coordinate [Fe(TFPPBr)(1-MeIm)] was studied by multiple-temperature solid-state M\u00f6ssbauer spectroscopy, which suggested that it is a low-spin complex with \u03b4 \u223c 0.32-0.38 mm/s and \u0394E \u223c 1.0 mm/s.",
        "keywords": "",
        "authors": [
            {
                "name": "Bin Hu",
                "org": "College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences , Yanqi Lake, Huairou District, Beijing 101408, China."
            },
            {
                "name": "Mingrui He",
                "org": "College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences , Yanqi Lake, Huairou District, Beijing 101408, China."
            },
            {
                "name": "Zhen Yao",
                "org": "College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences , Yanqi Lake, Huairou District, Beijing 101408, China."
            },
            {
                "name": "Charles E Schulz",
                "org": "Department of Physics, Knox College , Galesburg, Illinois 61401, United States."
            },
            {
                "name": "Jianfeng Li",
                "org": "College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences , Yanqi Lake, Huairou District, Beijing 101408, China."
            }
        ],
        "venue": "Inorganic chemistry",
        "year": 2016
    },
    "Yx9zE4kq": {
        "id": "Yx9zE4kq",
        "title": "Vitamin D levels correlate with lymphocyte subsets in elderly patients with age-related diseases.",
        "abstract": "Hypovitaminosis D is associated with age-related illnesses, including hypertension, cardiovascular disease (CRVD), cerebrovascular disease (CAD) and type 2 diabetes mellitus (T2DM). In our retrospective observational study, blood samples of elderly healthy controls (n\u2009=\u2009461) and patients with age-related diseases (n\u2009=\u20098,621) were subjected to flow-cytometry in order to determine correlations between age-related diseases and cluster of differentiation 4 (CD4), CD8, CD3, and CD19 lymphocyte markers, as well as serum levels of 25-hydroxyvitamin D (25(OH)D) and 25-hydroxyvitamin D (25(OH)D). More than 70% of the patients in each disease group had total vitamin D\u2009<\u200920\u2009ng/mL (P\u2009<\u20090.001). In CRVD patients, CD3 and CD19 correlated (P\u2009<\u20090.05) with 25(OH)D. In CAD patients, CD8, CD4, CD19 and CD4/CD8 correlated (P\u2009<\u20090.05) with 25(OH)D, and CD8 correlated (P\u2009<\u20090.05) with 25(OH)D. In T2DM and hypertension patients, CD8, CD3, CD19 and CD4/CD8 correlated with 25(OH)D. Progressive trends (P\u2009<\u20090.05) towards increased CD8 and CD4/CD8 were observed in vitamin-D-deficient T2DM and hypertension patients. Significant differences (P\u2009<\u20090.05) in CD8 were observed in vitamin-D-deficient CAD patients, whereas significant differences (P\u2009<\u20090.05) in CD8 and CD19 were observed in CRVD patients. Higher CD8 and CD4/CD8 in 25(OH)D-deficient T2DM and hypertension patients suggested a Th1 lymphocyte profile induction. Increases in CD8-positive lymphocytes suggested a similar, less pronounced effect in vitamin-D-deficient CRVD and CAD patients.",
        "keywords": "",
        "authors": [
            {
                "name": "Xudong Mao",
                "org": "Department of Geriatrics, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China. maoxudong111717@163.com."
            },
            {
                "name": "Bin Hu",
                "org": "Department of Respiratory, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China. hubing199@163.com."
            },
            {
                "name": "Zhiwen Zhou",
                "org": "Department of Cardiology, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China. zhouzhiwenufo@sina.com."
            },
            {
                "name": "Xubin Xing",
                "org": "Department of Cardiology, Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China."
            },
            {
                "name": "Yan Wu",
                "org": "Department of Psychiatry, Shanghai Mental Health Center, Shanghai, China."
            },
            {
                "name": "Jing Gao",
                "org": "Department of Information, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Yue He",
                "org": "Department of Cardiology, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Ying Hu",
                "org": "Department of Geriatrics, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Qihong Cheng",
                "org": "Department of Geriatrics, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China."
            },
            {
                "name": "Qing Gong",
                "org": "Department of Geriatrics, Zhongshan-Xuhui Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai, China."
            }
        ],
        "venue": "Scientific reports",
        "year": 2018
    },
    "Ruwh7mqd": {
        "id": "Ruwh7mqd",
        "title": "One Electron Makes Differences: From Heme {FeNO}7 to {FeNO}8",
        "abstract": "",
        "keywords": [
            "enzymes",
            "crystal structure",
            "iron",
            "enzyme",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "bin hu",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jianfeng li",
                "org": "chinese academy of sciences"
            }
        ],
        "venue": "Angewandte Chemie",
        "year": 2015
    },
    "5ZYaoXLf": {
        "id": "5ZYaoXLf",
        "title": "Entropy Perturbations in N-flation Model",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ronggen cai",
                "org": ""
            },
            {
                "name": "bin hu",
                "org": ""
            },
            {
                "name": "yunsong piao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2009
    },
    "oYmKyfKs": {
        "authors": [
            {
                "name": "Liping Liu",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Jinglin Kong",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Xiao Xie",
                "org": "SEU-FEI Nano-Pico Center, Key Laboratory of MEMS of Ministry of Education"
            },
            {
                "name": "Hongwen Wu",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Xiaofeng Ye",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Zhiliang Zhao",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Lei Wang",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Quanjun Liu",
                "org": "State Key Laboratory of Bioelectronics"
            }
        ],
        "title": "Gold nanorod translocation through a solid-state nanopore",
        "keywords": [
            "Gold nanorod",
            "Nanoparticles",
            "Solid-state nanopore",
            "Translocation events"
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2014,
        "id": "oYmKyfKs"
    },
    "Kia7LPPD": {
        "authors": [
            {
                "name": "Liping Liu",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Xiao Xie",
                "org": "SEU-FEI Nano-Pico Center"
            },
            {
                "name": "Jinglin Kong",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Hongwen Wu",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Quanjun Liu",
                "org": "State Key Laboratory of Bioelectronics"
            }
        ],
        "title": "Voltage dependence resistive pulse of lambda-DNA translocation with different size solid-state nanopore sensor",
        "keywords": [
            "Current blockage",
            "Diffusion constant",
            "Double-strand DNA",
            "Electrophoretic mobility",
            "Solid-state nanopore",
            "Translocation time"
        ],
        "venue": "Science of Advanced Materials",
        "year": 2013,
        "id": "Kia7LPPD"
    },
    "RLlwVpzc": {
        "authors": [
            {
                "name": "Jinglin Kong",
                "org": ""
            },
            {
                "name": "Hongwen Wu",
                "org": ""
            },
            {
                "name": "Liping Liu",
                "org": ""
            },
            {
                "name": "Xiao Xie",
                "org": ""
            },
            {
                "name": "Lingzhi Wu",
                "org": ""
            },
            {
                "name": "Xiaofeng Ye",
                "org": ""
            },
            {
                "name": "Quanjun Liu",
                "org": ""
            }
        ],
        "title": "Silicon nitride nanopores for nanoparticle sensing",
        "keywords": [
            "Nanoparticle",
            "Silicon nitride nanopore",
            "Translocation"
        ],
        "venue": "Journal of Nanoscience and Nanotechnology",
        "year": 2013,
        "id": "RLlwVpzc"
    },
    "lVDMJsf1": {
        "authors": [
            {
                "name": "Quanjun Liu",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Hongwen Wu",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Lingzhi Wu",
                "org": "School of Geography and Biological Information"
            },
            {
                "name": "Xiao Xie",
                "org": "SEU-FEI Nano-pico Center"
            },
            {
                "name": "Jinglin Kong",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Xiaofeng Ye",
                "org": "State Key Laboratory of Bioelectronics"
            },
            {
                "name": "Liping Liu",
                "org": "State Key Laboratory of Bioelectronics"
            }
        ],
        "title": "Voltage-Driven Translocation of DNA through a High Throughput Conical Solid-State Nanopore",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2012,
        "id": "lVDMJsf1"
    },
    "scN5jacy": {
        "authors": [
            {
                "name": "Liping Liu",
                "org": ""
            },
            {
                "name": "Hongwen Wu",
                "org": ""
            },
            {
                "name": "Jinglin Kong",
                "org": ""
            },
            {
                "name": "Quanjun Liu",
                "org": ""
            }
        ],
        "title": "Solid-state nanopore for rod-like virus detection",
        "keywords": [
            "Current drop",
            "Diffusion constant",
            "Electrophoretic mobility",
            "fd virus",
            "Solid-state nanopore",
            "Translocation time"
        ],
        "venue": "Science of Advanced Materials",
        "year": 2013,
        "id": "scN5jacy"
    },
    "qjT1fXV6": {
        "authors": [
            {
                "name": "Hongwei Zhu",
                "org": "College of Life Science"
            },
            {
                "name": "Sen Yang",
                "org": "MOE Key Laboratory of Arid and Grassland Ecology"
            },
            {
                "name": "Xuzhe Zhao",
                "org": "MOE Key Laboratory of Arid and Grassland Ecology"
            },
            {
                "name": "Youcai Xiong",
                "org": "MOE Key Laboratory of Arid and Grassland Ecology"
            },
            {
                "name": "Shaoming Wang",
                "org": "College of Life Science"
            },
            {
                "name": "Xia Zhang",
                "org": "College of Life Science"
            }
        ],
        "title": "Recent advances on regional climate change by statistical downscaling methods",
        "abstract": "The statistical downscaling methods (SDMs) are reasonable forecast tools which were recently proposed for climate change scenarios at a regional scale. The SDM are used to establish large-scale climate factors, the regional statistical relationship between the climate factors using years of observations of atmospheric circulation, and to test the suitability of this relationship using independent observations. Furthermore, the relationship is applied to atmospheric general circulation models (Global atmospheric general circulation models, GCMs) to produce large-scale climate information and predict future regional climate change scenarios (such as temperature and precipitation). In recent years, a variety of sophisticated statistical downscaling methods have been developed to meet the needs of domestic and international climate prediction programs and to provide effective support for regional ecosystem management. However, the choice of different statistical methods in a particular region must be highly targeted and effective. It is widely accepted that reasonable and consistent meteorological input data is a critical factor for modeling regional climate change at different levels. Previous studies showed that the GCMs provide the means of estimating climate change in the future by providing a time series of climatic variables. However, there are two main problems if GCM outputs are directly used for regional impact studies: 1) they are biased with respect to observations of present climate, and 2) the spatial scale is frequently too coarse. Therefore, dynamic downscaling methods employ regional climate models (RCMs), using the output of GCMs as forcing and boundary conditions. The RCMs provide sufficient information for ecological and hydrological modeling of the impact of expected climate change at different levels. Over the last decade, quite a few studies on the SDMs have been conducted and applied in ecological prediction. The recently proposed theory \"coupling human and natural systems\" provides us with the possibility of incorporating the SDM in ecological prediction. In this paper, we designed a flow chart to illustrate the method of ecological forecasting. Due to the complexity of ecological processes, we collected a series of factors including social and natural factors which influence the changes in ecosystem and regional climate. The model proposed here will undoubtedly validite and emphasize the importance of the accuracy of the results on ecological forecasting. In the past 10 years, some scholars have developed new techniques or methods to forecast ecological phenomena, such as biological invasion, agroecological safety, forest carbon sinks, biological diversity change, the ecological carrying capacity and other forecasts. Significant breakthroughs have been achieved in the SDMs of the interactions between climate change and ecological forecasts. Recent advances on connotation and extension of the concept, basic principles and operating procedures of SDMs were summarized. This paper summarizes the applicable progress, hot issues and developmental trends of the SDMs in simulating regional climate change. The review provides some initial approaches for the construction of meteorological and ecological prediction models and serves as a reference for related research.",
        "keywords": [
            "Advances",
            "Ecological forecasts",
            "Estimation of regional climate",
            "Global change",
            "Statistical downscaling methods"
        ],
        "venue": "Shengtai Xuebao/ Acta Ecologica Sinica",
        "year": 2011,
        "id": "qjT1fXV6"
    },
    "gKJVGVCg": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "College of Life Sciences"
            },
            {
                "name": "Wenling Wang",
                "org": "College of Life Sciences"
            },
            {
                "name": "Huan Ge",
                "org": "College of Life Sciences"
            },
            {
                "name": "Lihong Long",
                "org": "College of Life Sciences"
            },
            {
                "name": "Shao-Ming Wang",
                "org": "College of Life Sciences"
            }
        ],
        "title": "Spatial distribution patterns of seedling emergence of Stipagrostis pennata in Gurbantonggut Desert",
        "abstract": "The aim of this study was to investigate the spatial distribution patterns and the amounts of seedling density of S. pennata in different sample dunes in Gurbantonggut Desert. Results indicate that spatial patterns of seedling emergence of S. pennata were of general similar with the distribution patterns of its associated standing vegetations, and was greatly associated with spatial distribution of the threshold wind (\u22656m.s ",
        "keywords": [
            "Junger basin",
            "Population",
            "Seedling",
            "Spatial distribution pattern",
            "Stipagrostis pennata"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "gKJVGVCg"
    },
    "P7LiVwUS": {
        "authors": [
            {
                "name": "Guodong Cao",
                "org": "College of Life Science"
            },
            {
                "name": "Jiehua Chen",
                "org": "College of Life Science"
            },
            {
                "name": "Jun Xia",
                "org": "College of Life Science"
            },
            {
                "name": "Hongwei Zhu",
                "org": "College of Life Science"
            },
            {
                "name": "Yongchao Jiang",
                "org": "College of Life Science"
            },
            {
                "name": "Xia Zhang",
                "org": "College of Life Science"
            },
            {
                "name": "Shaoming Wang",
                "org": "College of Life Science"
            }
        ],
        "title": "Analysis of soil physical properties under different vegetation types in the alluvial fan area of Manas River watershed",
        "abstract": "Soil physical properties of four vegetation types (Tamarix ramosissima, Halostachys caspica, Nitraria sibirica, Salsola spp.) were investigated in the alluvial fan area of Manas River watershed. The main results showed that in the horizontal direction, soil pH, total salt content and soil bulk density of Tamarix ramosissima were the lowest within the depth of 1m soil profile, and were 8. 75, 0. 97g/ kg and 1. 42g/ cm",
        "keywords": [
            "Manas river watershed",
            "Physical properties",
            "Saline-alkali soil",
            "Vegetation types"
        ],
        "venue": "Shengtai Xuebao/ Acta Ecologica Sinica",
        "year": 2013,
        "id": "P7LiVwUS"
    },
    "mKAfatoC": {
        "authors": [
            {
                "name": "Jinna Tu",
                "org": "College of Life Science"
            },
            {
                "name": "Youcai Xiong",
                "org": "MOE Key Laboratory of Arid and Grassland Ecology"
            },
            {
                "name": "Xia Zhang",
                "org": "College of Life Science"
            },
            {
                "name": "Yan Yang",
                "org": "College of Life Science"
            },
            {
                "name": "Lijie Zhu",
                "org": "College of Life Science"
            },
            {
                "name": "Jiehua Chen",
                "org": "College of Life Science"
            },
            {
                "name": "Zhihua Li",
                "org": "MOE Key Laboratory of Arid and Grassland Ecology"
            },
            {
                "name": "Shaoming Wang",
                "org": "College of Life Science"
            }
        ],
        "title": "\"Fertile island\" features of soil available nutrients around Halostachys caspica shrub in the alluvial fan area of Manas River watershed",
        "abstract": "Spatial distribution and regulatory mechanism of available soil nutrients is widely considered as an important issue in plant and soil relations in arid areas, in which the impact of interaction between different plant populations on spatial distribution of soil available nutrients has been little reported. According to Liang et al. (2010), soil-plant interactions and sustainability of eco-agriculture in arid region is a crucially important topic to address. Manas River watershed is situated at the areas between northern slope of Tianshan Mountain and south edge of Junggar watershed, where the alluvial fan area of the watershed is a severely saline and alkaline eco-agricultural region in northwest China. In this study, a comparative experiment was conducted to reveal the \"fertile island\" features of soil available nutrients around the halostachys (Halostashys caspica) shrub under the conditions of single population and companion population with salsola (Salsola collina) in the alluvial fan areas of Manas River watershed. The results showed that soil \"fertile island\" effect around halostachys shrubs was mainly focused on the soil surface, and tended to be weakened gradually at intervals of 0.6m outward the standing point, and to decrease along the soil depth. Under the condition of solitary halostachys population, there existed a clear enrichment distribution for both soil alkaline nitrogen (AN) and available potassium (AK) along with the standing center. In the surface soil of 3m outward from standing point, the concentrations of these two nutrients were gradually lowered from 2.75 g/kg and 56.67 mg/kg to 1.66 g/kg and 29.0 mg/kg, and decreased significantly along the soil profile (P<0.05), yet were significantly higher than the corresponding values of bare land. For the change in available phosphorus (AP), there was a wholly deficit status in comparison with that of bare land, whose average content of AP was lower by 25.33% than the bare land. This result indicated that the Halostachys population has the ecological function to improve the enrichment of nitrogen and potassium, but lead to the consumption of phosphorus. However, no clear variation trend was observed along with the soil profile. On the other hand, under the symbiotic conditions of Halostachys and Salsola, the concentrations of three available nutrients in either the soil surface or along the soil profile were significantly higher than those of bare land. Furthermore, the soil AN concentrations were in general lower in symbiotic condition than those of solitary condition, but the AP and AK concentrations were greater in the former than those of the latter. Halostachys as a desert plant has a significant effect on the soil fertility, and the symbiotic interaction of Salsola leads to a more extensive and complementary influence on the \"fertile island\" effect of Halostachys shrub. Importantly, the loss of soil AP components in simplex Halostachys population can be reversed under the symbiotic conditions with Salsola population. This founding provides a theoretical potential for understanding plant and soil relations in arid saline regions, and a new practical approach to manage saline and alkaline soil for scientists and policy makers.",
        "keywords": [
            "Available nutrient",
            "Fertile island",
            "Halostachys caspica",
            "Manas River",
            "Symbiotic"
        ],
        "venue": "Shengtai Xuebao/ Acta Ecologica Sinica",
        "year": 2011,
        "id": "mKAfatoC"
    },
    "NfAY3gtT": {
        "authors": [
            {
                "name": "Cheng Zhu",
                "org": "Department of Urban"
            },
            {
                "name": "Chaogui Zheng",
                "org": "Department of Chuzhou Normal College"
            },
            {
                "name": "Chunmei Ma",
                "org": "Department of Urban"
            },
            {
                "name": "Xiaoxuan Yang",
                "org": "Department of Urban"
            },
            {
                "name": "Xizhen Gao",
                "org": "Department of Urban"
            },
            {
                "name": "Haiming Wang",
                "org": "Zhejiang Institute of Cultural Relics and Archaeology"
            },
            {
                "name": "Jiuhua Shao",
                "org": "Hemudu Site Museum of Zhejiang"
            }
        ],
        "title": "On the Holocene sea-level highstand along the Yangtze Delta and Ningshao Plain, East China",
        "abstract": "The temporal-spatial distribution of Neolithic sites shows a long period of absence of human settlements during the early Holocene on the Yangtze Delta, and the area has not been colonized until 7000 aBP, corresponding to the onset of the Majiabang culture. Besides the regions east to the sandbar of Maqiao Site in Shanghai, foraminifera are not found in Neolithic cultural layers since 7000 aBP, indicating a widespread transgression between 10000 and 7000 aBP. Evidence of radiocarbon-dated cultural relics, foraminifera and pollen records from the Hemudu Site suggests that the Hemudu culture emerged and developed during the mid-Holocene Climatic Optimum. Therefore, the hypothesis of a mid-Holocene sea-level highstand along the Yangtze Delta and Ningshao Plain from 7000 to 5000 aBP is an open debate. New evidence from archaeological excavations and bio-stratigraphy suggests that, prior to 7000 aBP, a high sea level occurred along the Ningshao Plain. Subsequently, the sea level was lowered between 7000 and 5000 aBP, and the area suffered from frequent floods from 5000 to 3900 aBP.",
        "keywords": [
            "Foraminifera",
            "Hemudu sile",
            "Holocene sea-level high-stand",
            "Ningshao Plain",
            "Pollen",
            "Yangtze Delta"
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2003,
        "id": "NfAY3gtT"
    },
    "JE9Hmxt2": {
        "authors": [
            {
                "name": "Nanjing Zhong",
                "org": "School of Food Science"
            },
            {
                "name": "Zhongyu Gui",
                "org": "College of Light Industry and Food Science"
            },
            {
                "name": "Li Xu",
                "org": "School of Chemistry and Chemical Engineering"
            },
            {
                "name": "Jianrong Huang",
                "org": "School of Food Science"
            },
            {
                "name": "Kun Hu",
                "org": "School of Food Science"
            },
            {
                "name": "Yongqing Gao",
                "org": "School of Food Science"
            },
            {
                "name": "Xia Zhang",
                "org": "College of Light Industry and Food Science"
            },
            {
                "name": "Zhenbo Xu",
                "org": "Department of Microbial Pathogenesis"
            },
            {
                "name": "Jianyu Su",
                "org": "College of Light Industry and Food Science"
            },
            {
                "name": "Bing Li",
                "org": "College of Light Industry and Food Science"
            }
        ],
        "title": "Solvent-free enzymatic synthesis of 1, 3-Diacylglycerols by direct esterification of glycerol with saturated fatty acids",
        "abstract": "Background: Pure 1, 3-diacylglycerols (1, 3-DAG) have been considered to be significant surfactants in food, cosmetics and pharmaceutical industries, as well as the effect on obesity prevention. Methods. In this study, a vacuum-driven air bubbling operation mode was developed and evaluated for the enzymatic synthesis of 1, 3-DAG of saturated fatty acids, by direct esterification of glycerol with fatty acids in a solvent-free system. The employed vacuum-driven air bubbling operation mode was comparable to vacuum-driven N\u00a7ssub\u00a72\u00a7esub\u00a7 bubbling protocol, in terms of lauric acid conversion and 1, 3-dilaurin content. Results: Some operation parameters were optimized, and 95.3% of lauric acid conversion and 80.3% of 1, 3-dilaurin content was obtained after 3-h reaction at 50\u00b0C, with 5 wt% of Lipozyme RM IM (based on reactants) amount. Of the lipases studied, both Lipozyme RM IM and Novozym 435 exhibited good performance in terms of lauric acid conversion. Lipozyme TL IM, however, showed low activity. Lipozyme RM IM showed good operational stability in this operation protocol, 80.2% of the original catalytic activity remained after 10 consecutive batch applications. Some other 1, 3-DAG were prepared and high content was obtained after purification: 98.5% for 1, 3-dicaprylin, 99.2% for 1, 3-dicaprin, 99.1% for 1, 3-dilaurin, 99.5 for 1, 3-dipalmitin and 99.4% for 1, 3-disterin. Conclusion: The established vacuum-driven air bubbling operation protocol had been demonstrated to be a simple-operating, cost-effective, application practical and efficient methodology for 1, 3-DAG preparation. \u00a9 2013 Zhong et al.; licensee BioMed Central Ltd.",
        "keywords": [
            "1, 3-diacylglycerol",
            "Air-bubbling",
            "Enzyme",
            "Synthesis"
        ],
        "venue": "Lipids in Health and Disease",
        "year": 2013,
        "id": "JE9Hmxt2"
    },
    "beSu3Va2": {
        "authors": [
            {
                "name": "Yun Hu",
                "org": ""
            },
            {
                "name": "Xia Zhang",
                "org": ""
            },
            {
                "name": "Chaohai Wei",
                "org": ""
            }
        ],
        "title": "Simple preparation of Mn-N-codoped titania photocatalyst with visible light response",
        "abstract": "Mn-N-codoped TiO",
        "keywords": [
            "Mn-N-codoped TiO2",
            "Photocatalyst",
            "Visible light response"
        ],
        "venue": "Research on Chemical Intermediates",
        "year": 2010,
        "id": "beSu3Va2"
    },
    "tsZuQ0QC": {
        "authors": [
            {
                "name": "Yun Hu",
                "org": "College of Environmental Science and Engineering"
            },
            {
                "name": "Xia Zhang",
                "org": "College of Environmental Science and Engineering"
            },
            {
                "name": "Chaohai Wei",
                "org": "College of Environmental Science and Engineering"
            }
        ],
        "title": "Synthesis of Mn-N-codoped TiO2 photocatalyst and its photocatalytic reactivity under visible light irradiation",
        "abstract": "Visible-light responsible Mn-N-codoped TiO",
        "keywords": [
            "Mn-N-codoped TiO2",
            "Photocatalyst",
            "Visible light response"
        ],
        "venue": "Materials Science Forum",
        "year": 2009,
        "id": "tsZuQ0QC"
    },
    "WzTzEz3P": {
        "authors": [
            {
                "name": "Ning Liu",
                "org": ""
            },
            {
                "name": "Ruiyuan Zheng",
                "org": ""
            },
            {
                "name": "Wanyi Liu",
                "org": ""
            },
            {
                "name": "Jinxin Ma",
                "org": ""
            },
            {
                "name": "Xia Zhang",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            },
            {
                "name": "Zheng Wang",
                "org": ""
            }
        ],
        "title": "Preparation and characterization of magenetically core-shell structure carbon based solid sulfonic acid",
        "abstract": "Magnetic core-shell structure carbon based solid sulfonic acid was prepared and characterized systematically. In a typical procedure, Fe",
        "keywords": [
            "Characterization",
            "Magnetic core-shell carbon based solid acid",
            "Preparation",
            "Sulfonation"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "WzTzEz3P"
    },
    "FDmZqRah": {
        "authors": [
            {
                "name": "Qian Gong",
                "org": ""
            },
            {
                "name": "Yun Hu",
                "org": ""
            },
            {
                "name": "Chaohai Wei",
                "org": ""
            },
            {
                "name": "Xia Zhang",
                "org": ""
            }
        ],
        "title": "Study on the photocatalytic properties of Mn, N-doped TiO 2 prepared at different calcination temperatures",
        "abstract": "A series of Mn-doped TiO ",
        "keywords": [
            "Calcination temperature",
            "Mn-N-codoping",
            "TiO 2 photocatalyst",
            "Visible light response"
        ],
        "venue": "Huanjing Kexue Xuebao/Acta Scientiae Circumstantiae",
        "year": 2012,
        "id": "FDmZqRah"
    },
    "oArUsV6v": {
        "authors": [
            {
                "name": "Jian-Rong Huang",
                "org": "School of Light Industry and Food Sciences"
            },
            {
                "name": "Bing Li",
                "org": "School of Light Industry and Food Sciences"
            },
            {
                "name": "Xia Zhang",
                "org": "School of Light Industry and Food Sciences"
            },
            {
                "name": "Lin Li",
                "org": "School of Light Industry and Food Sciences"
            }
        ],
        "title": "Chromatography separation and structure identification of enzymatically-synthesized naringin palmitate",
        "abstract": "First, preparative high-pressure liquid chromatography was used to isolate and purify the naringin palmitate enzymatically synthesized by immobilized lipase Novozym 435",
        "keywords": [
            "High-pressure liquid chromatography",
            "Lipase",
            "Naringin palmitate",
            "Regioselectivity",
            "Structure"
        ],
        "venue": "Huanan Ligong Daxue Xuebao/Journal of South China University of Technology (Natural Science)",
        "year": 2010,
        "id": "oArUsV6v"
    },
    "sizJtzeI": {
        "authors": [
            {
                "name": "Hongjia Lin",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Lin Li",
                "org": "Guangdong Province Key Laboratory for Green Processing Of Natural Products and Product"
            },
            {
                "name": "Yingjuan Tian",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Xia Zhang",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Bing Li",
                "org": "Guangdong Province Key Laboratory for Green Processing Of Natural Products and Product"
            }
        ],
        "title": "Protein hydrolysate from brewer's spent grain and its inhibitory ability of \u03b1-glucosidase",
        "abstract": "Brewer's spent grain (BSG) rich in proteins is the main by-products in brewery. BSC proteins were extracted and hydrolyzed by Alcalase. The effects of hydrolysis time, temperature, pH and amount of enzyme added on the peptide yield were investigated. Inhibition of BSG protein hydrolysate against \u03b1-glucosidase was evaluated in vitro. BSG protein hydrolysate at 4.0 mg/mL showed the inhibition of 21.42% against \u03b1-glucosidase. The BSG protein hydrolysate after ultrafiltration purification exhibited much higher inhibition than that without ultrafiltration purification. The inhibition of BSC protein hydrolysate fraction with molecular weight fraction less than 5 kDa was 56.41%. \u00a9 (2012) Trans Tech Publications, Switzerland.",
        "keywords": [
            "\u03b1-glucosidase",
            "Brewer's spent grain",
            "Inhibitory activity",
            "Peptide"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "sizJtzeI"
    },
    "DYLLBGVl": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": ""
            },
            {
                "name": "Lin Li",
                "org": ""
            },
            {
                "name": "Zhenbo Xu",
                "org": ""
            },
            {
                "name": "Zhili Liang",
                "org": ""
            },
            {
                "name": "Jianyu Su",
                "org": ""
            },
            {
                "name": "Jianrong Huang",
                "org": ""
            },
            {
                "name": "Bing Li",
                "org": ""
            }
        ],
        "title": "Investigation of the Interaction of Naringin Palmitate with Bovine Serum Albumin: Spectroscopic Analysis and Molecular Docking",
        "abstract": "Background: Bovine serum albumin (BSA) contains high affinity binding sites for several endogenous and exogenous compounds and has been used to replace human serum albumin (HSA), as these two compounds share a similar structure. Naringin palmitate is a modified product of naringin that is produced by an acylation reaction with palmitic acid, which is considered to be an effective substance for enhancing naringin lipophilicity. In this study, the interaction of naringin palmitate with BSA was characterised by spectroscopic and molecular docking techniques. Methodology/Principal Findings: The goal of this study was to investigate the interactions between naringin palmitate and BSA under physiological conditions, and differences in naringin and naringin palmitate affinities for BSA were further compared and analysed. The formation of naringin palmitate-BSA was revealed by fluorescence quenching, and the Stern-Volmer quenching constant (K",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2013,
        "id": "DYLLBGVl"
    },
    "gqb3fFys": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Lin Li",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Jian-rong Huang",
                "org": "School of Food Science"
            },
            {
                "name": "Ling Chen",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Xiao-xi Li",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Guo-qin Liu",
                "org": "College of Light Industry and Food Sciences"
            },
            {
                "name": "Bing Li",
                "org": "College of Light Industry and Food Sciences"
            }
        ],
        "title": "Enzymatic synthesis of naringin palmitate",
        "abstract": "Naringin esters are paid more attention in medical and functional food industry than naringin due to their higher stability and solubility in lipidic environments. Naringin palmitic acid esters were enzymatically synthesized with naringin and palmitic acid. The effects of solvent type, temperature, concentration and types of enzymes and the molar ratio of substrates on the conversion of naringin were investigated. Novozym 435 performed higher catalytic ability in tert-amyl alcohol in the esterification of naringin with palmitic acid. The conversion yield of naringin increased with the increase of temperature (30-70\u00b0C) and of the concentration of enzyme. The structure of the naringin palmitate was characterized by FT-IR, ",
        "keywords": [
            "Enzymatic synthesis",
            "Naringin",
            "Naringin palmitate",
            "Palmitic acid"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "gqb3fFys"
    },
    "XmfJwrBP": {
        "authors": [
            {
                "name": "J. Chen",
                "org": "Academy of Life and Envt. Science"
            },
            {
                "name": "J. Lin",
                "org": "Academy of Life and Envt. Science"
            }
        ],
        "title": "Determination of dissolved iron(II) and iron(III) in water with 5-Br-PAN-S by solid phase spectrophotometry",
        "abstract": "A very sensitive and selective method for the determination of trace amounts of iron(II) and iron(III) by SPS has been developed. It is based on the fixation of iron(II) as 1-(5-bromo-2-pyridylazo)-2-naphthol-6-sulphonic acid (5-Br-PAN-S) complex on a styrene-divinylbenzene anion-exchange resins. The absorbances of resin sorbed iron(II) complex is measured directly at 765 and 850 nm. Iron(III) was determined by difference measurements after reduction of iron(III) to iron(II) with hydroxylamine. The linear range of the determination is 0-25\u03bcg for iron(II) or total iron. The detection limit for a sample volume of 100ml using 0.5g of anion-exchange, corresponds to 2.1 \u03bcg l",
        "keywords": [
            "5-Br-PAN-S",
            "Determination",
            "Iron(II) and iron(III)",
            "Solid phase spectrophotometry"
        ],
        "venue": "Analytical Letters",
        "year": 2001,
        "id": "XmfJwrBP"
    },
    "d5vqaSiM": {
        "authors": [
            {
                "name": "R. Hu",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "Y. Pei",
                "org": "State Key Laboratory of Optoelectronics Materials and Technologies"
            },
            {
                "name": "Z. Chen",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "J. Yang",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "Y. Li",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "J. Lin",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "Y. Zhao",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "C. Wang",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "J. Liang",
                "org": "School of Physics and Engineering"
            },
            {
                "name": "B. Fan",
                "org": "Institutes of Advanced Technology"
            },
            {
                "name": "G. Wang",
                "org": "State Key Laboratory of Optoelectronics Materials and Technologies"
            }
        ],
        "title": "Ultra-High Field-Effect Mobility Thin-Film Transistors with Metal-Organic Chemical Vapor Deposition Grown In",
        "abstract": "In this letter, thin-film transistors (TFTs) were demonstrated with In",
        "keywords": [
            "High mobility",
            "indium oxide",
            "metal organic chemical vapor deposition (MOCVD)",
            "thin-film transistors (TFTs)"
        ],
        "venue": "IEEE Electron Device Letters",
        "year": 2015,
        "id": "d5vqaSiM"
    },
    "xD9kUWjs": {
        "id": "xD9kUWjs",
        "title": "The mitochondrial genome of Janthicuomyia sp. (Diptera, Tachinidae)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Peng Hou",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China;"
            },
            {
                "name": "Shang Gao",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China;"
            },
            {
                "name": "Xin Li",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China;"
            },
            {
                "name": "Ding Yang",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China;"
            },
            {
                "name": "Chuntian Zhang",
                "org": "College of Life Science, Shenyang Normal University, Shenyang, China"
            }
        ],
        "venue": "Mitochondrial DNA Part B",
        "year": 2019
    },
    "QN1qZNIf": {
        "id": "QN1qZNIf",
        "title": "The complete mitochondrial genome analysis of Eristalis tenax (Diptera, Syrphidae)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaoli Li",
                "org": ""
            },
            {
                "name": "Shuangmei Ding",
                "org": ""
            },
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Peng Hou",
                "org": ""
            },
            {
                "name": "Chufei Tang",
                "org": ""
            },
            {
                "name": "Ding Yang",
                "org": ""
            }
        ],
        "venue": "Mitochondrial DNA Part B",
        "year": 2017
    },
    "vXCYl1t7": {
        "id": "vXCYl1t7",
        "title": "The mitochondrial genome of Syntormon pallipes (Diptera: Dolichopodidae)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Peng Hou",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China"
            },
            {
                "name": "Qilemoge",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China"
            },
            {
                "name": "Xin Li",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China"
            },
            {
                "name": "Ding Yang",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China"
            }
        ],
        "venue": "Mitochondrial DNA Part B",
        "year": 2019
    },
    "AD4JFTdE": {
        "id": "AD4JFTdE",
        "title": "The mitochondrial genome of Drino Sp. (Diptera, Tachinidae)",
        "abstract": "AbstractThe tachinid fly Drino sp. belongs to the subfamily Exoristinae of Tachinidae. We sequenced and annotated the mitogenome of Drino sp. which makes this species first representative of the tribe Eryciini (Tachinidae: Exoristinae) with nearly complete mitochondrial data. This mitogenome is 15437\u2009bp in total, which consists of 22 transfer RNAs, 13 protein-coding genes, 2 ribosomal RNAs and non-coding control region. All genes have the conservational arrangement with other published species of Tachinidae. The nucleotide composition biases toward A and T, the overall A\u2009+\u2009T% was up to 80.4% of the entire mitogenome. Bayesian inference analysis strongly supported the monophyly of Tachinidae and Exoristinae. Our results also suggested that Exoristinae is the sister group to Phasiinae, and Dexiinae is the sister group to the clade of Phasiinae\u2009+\u2009Exoristinae.",
        "keywords": "",
        "authors": [
            {
                "name": "Peng Hou",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China;"
            },
            {
                "name": "Shuangmei Ding",
                "org": "College of Plant Protection, China Agricultural University, Beijing, China;"
            },
            {
                "name": "Xin Li",
                "org": "College of Life Science, Shenyang Normal University, Shenyang, China;"
            },
            {
                "name": "Ding Yang",
                "org": ""
            },
            {
                "name": "Chuntian Zhang",
                "org": "College of Life Science, Shenyang Normal University, Shenyang, China;"
            },
            {
                "name": "Qiang Wang",
                "org": "Shanghai Entry-Exit Inspection and Quarantine Bureau of China, Technical Center for Animal Plant and Food Inspection and Quarantine, Shanghai, China"
            }
        ],
        "venue": "Mitochondrial DNA Part B",
        "year": 2018
    },
    "ASnzsbD9": {
        "id": "ASnzsbD9",
        "title": "Mitochondrial genome analysis of Ectophasia roundiventris (Diptera, Tachinidae)",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Xin Li",
                "org": ""
            },
            {
                "name": "Shuangmei Ding",
                "org": ""
            },
            {
                "name": "Peng Hou",
                "org": ""
            },
            {
                "name": "Xiaoyan Liu",
                "org": ""
            },
            {
                "name": "Chuntian Zhang",
                "org": ""
            },
            {
                "name": "Ding Yang",
                "org": ""
            }
        ],
        "venue": "Mitochondrial DNA Part B",
        "year": 2017
    },
    "jo9hRL7j": {
        "id": "jo9hRL7j",
        "title": "p38 MAPK pathway in high-glucose induced activation of rat mesangial cells",
        "authors": [
            {
                "name": "WANG Li-hui",
                "org": ".Department of Nephrology,Norman Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "WU Guang-li",
                "org": ".Department of Nephrology,Norman Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "ZHANG Li-xia",
                "org": ".Department of Nephrology,Norman Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "HUANG Xu-dong",
                "org": ".Department of Nephrology,Norman Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "LI Sai",
                "org": ".Department of Nephrology,Norman Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            }
        ],
        "venue": "medical journal of chinese people's liberation army",
        "keywords": [
            "glumerular mesangial cells",
            "transforming growth factor beta1",
            "cyclic AMP response element-binding protein",
            "p38 mitogen-activated protein kinases"
        ],
        "year": 2009
    },
    "Voz2CHHN": {
        "id": "Voz2CHHN",
        "title": "Role of Endothelin in Development of Overtraining-induced Acute Kidney Injury and the Effects of Anisodamine on Exhausted Rats",
        "authors": [
            {
                "name": "WU Guangli",
                "org": ",et al Division of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang%%#%%#"
            },
            {
                "name": "ZHANG Lixia",
                "org": ",et al Division of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang%%#%%#"
            },
            {
                "name": "ZHANG Wenyu",
                "org": ",et al Division of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang%%#%%#"
            }
        ],
        "venue": "chinese journal of integrated traditional and western nephrology",
        "keywords": [
            "Overtraining Kidney injury Endothelin-1 Pathogenesis Anisodamine Rat"
        ],
        "year": 2009
    },
    "1ceF4NqF": {
        "id": "1ceF4NqF",
        "title": "Blood Purification Therapy in Treatment of Rhabdomyolysis Induced by Over Military Training and Complicated with Multiple Organ Dysfunction Syndrome Involved in Acute Renal Failure",
        "authors": [
            {
                "name": "ZHANG Li-xia",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Research Center of Nephrological Diseases of Beijing Military Area Command,Shijiazhuang ,China"
            },
            {
                "name": "WU Guang-li",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Research Center of Nephrological Diseases of Beijing Military Area Command,Shijiazhuang ,China"
            },
            {
                "name": "WANG Li-hui",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Research Center of Nephrological Diseases of Beijing Military Area Command,Shijiazhuang ,China"
            },
            {
                "name": "HUANG Xu-dong",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Research Center of Nephrological Diseases of Beijing Military Area Command,Shijiazhuang ,China"
            }
        ],
        "venue": "clinical misdiagnosis & mistherapy",
        "keywords": [
            "Blood purification therapy",
            "Multiple organ failure",
            "Rhabdomyolysis",
            "Military training",
            "Kidney failure"
        ],
        "year": 2012
    },
    "PsKzl05m": {
        "id": "PsKzl05m",
        "title": "Effect and Functional Mechanisms of Fluvastatin on the Expressions of Connective Tissue Growth Factor mRNA in Glomerular Mesangial Cells Cultivated with High Concentration of Glucose in Rats",
        "authors": [
            {
                "name": "WANG Li-hui"
            },
            {
                "name": "WU Guang-li"
            },
            {
                "name": "ZHANG Li-xia"
            },
            {
                "name": "LI Sai"
            },
            {
                "name": "HUANG Xu-dong"
            }
        ],
        "venue": "medical & pharmaceutical journal of chinese people's liberation army",
        "keywords": [
            "Rat",
            "cAMP response element-bingding protein1",
            "Connective tissue growth factor",
            "Mesangial cell",
            "Hydroxymethylglutaryl-coA reductase inhibitors",
            "p38 mitogen activated protein kinase",
            "Fluvatatin",
            "wistar"
        ],
        "year": 2013
    },
    "BPGdga2R": {
        "id": "BPGdga2R",
        "title": "Valsartan inhibits the expression of connective tissue growth factor in rat glomerular mesangial cells incubated with high concentration glucose",
        "authors": [
            {
                "name": "WANG Li-hui",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "WU Guang-li",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "ZHANG Li-xia",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "HUANG Xu-dong",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            },
            {
                "name": "LI Sai",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,Shijiazhuang ,China"
            }
        ],
        "venue": "basic & clinical medicine",
        "keywords": [
            "P38 mitogen-activated protein kinase",
            "connective tissue growth factor",
            "valsartan",
            "cAMP response element binding protein 1",
            "mesangialcells"
        ],
        "year": 2009
    },
    "R9bsVbxk": {
        "id": "R9bsVbxk",
        "title": "Expression of connective tissue growth factor mRNA and its mechanism in the high glucose induced rat mesangial cells",
        "authors": [
            {
                "name": "WANG Li-hui"
            },
            {
                "name": "DUAN Hui-jun"
            },
            {
                "name": "WU Guang-li"
            },
            {
                "name": "SHI Yong-hong"
            },
            {
                "name": "ZHANG Li-xia"
            },
            {
                "name": "HUANG Xu-dong"
            }
        ],
        "venue": "chinese journal of pathophysiology",
        "keywords": [
            "Concentration of high glucose",
            "Connective tissue growth factor",
            "Mesangial cells",
            "Signal transduction"
        ],
        "year": 2009
    },
    "jh9xnlPp": {
        "id": "jh9xnlPp",
        "title": "The Role of Angiotensin \u2161 in Development of Overtraining-Induced Acute Kidney Injury in Rats",
        "authors": [
            {
                "name": "Zhang Lixia",
                "org": " Department of Nephorology,Bethune International Peace Hospital of PLA,Shijiazhuang "
            },
            {
                "name": "Wu Guangli",
                "org": " Department of Nephorology,Bethune International Peace Hospital of PLA,Shijiazhuang "
            },
            {
                "name": "Huang Xudong",
                "org": " Department of Nephorology,Bethune International Peace Hospital of PLA,Shijiazhuang "
            }
        ],
        "venue": "chinese journal of microcirculation",
        "keywords": [
            "Rat",
            "Overtraining",
            "Acute kidney injury",
            "Angiotensin \u2161",
            "Pathogenesis"
        ],
        "year": 2008
    },
    "npLKTB22": {
        "id": "npLKTB22",
        "title": "Effect of hemodialysis plus hemoperfusion on the patients of acute fatty liver of pregnancy associated with multiple organ dysfunction syndrome",
        "authors": [
            {
                "name": "WANG Li-hui",
                "org": ",et al.Department of Nephrology,Bethune International Peace Hospital,Shijiazhuang ,China"
            },
            {
                "name": "WU Guang-li",
                "org": ",et al.Department of Nephrology,Bethune International Peace Hospital,Shijiazhuang ,China"
            },
            {
                "name": "ZHANG Li-xia",
                "org": ",et al.Department of Nephrology,Bethune International Peace Hospital,Shijiazhuang ,China"
            }
        ],
        "venue": "chinese journal of critical care medicine",
        "keywords": [
            "Multiple organ dysfunction syndrome",
            "Acute fatty liver of pregnancy",
            "Hemoper-fusion"
        ],
        "year": 2008
    },
    "zTt6wPjH": {
        "id": "zTt6wPjH",
        "title": "Clinical Study of Overtraining-Induced Acute Kidney Injury",
        "authors": [
            {
                "name": "ZHANG Lixia",
                "org": ",et al Renal Division,Bethune International Peace Hospital of PLA,Shijiazhuang%%#%%#"
            },
            {
                "name": "WANG Lihui",
                "org": ",et al Renal Division,Bethune International Peace Hospital of PLA,Shijiazhuang%%#%%#"
            },
            {
                "name": "HUANG Xudong",
                "org": ",et al Renal Division,Bethune International Peace Hospital of PLA,Shijiazhuang%%#%%#"
            }
        ],
        "venue": "chinese journal of integrated traditional and western nephrology",
        "keywords": [
            "Overtraining Rhabdomyolysis Renal failure acute"
        ],
        "year": 2011
    },
    "BScEtC38": {
        "id": "BScEtC38",
        "title": "Effects of fluvastatin on the activation of p38 mitogen-activated protein kinase in glomerular mesangial cells under high concentration of glucose]",
        "authors": [
            {
                "name": "WANG Li-hui",
                "org": "Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "WU Guang-li",
                "org": "Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "ZHANG Li-xia",
                "org": "Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "HUANG Xu-dong",
                "org": "Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "LI Sai",
                "org": "Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            }
        ],
        "venue": "yao xue xue bao = acta pharmaceutica sinica",
        "keywords": [
            "3-hydroxy-3-methylglutaryl coa reductase inhibitor",
            "p38 mitogen-activated protein kinase",
            "fluvastatin",
            "transform growth factor-\u03b21",
            "mesangial cell",
            "camp response element-binding protein 1"
        ],
        "year": 2009
    },
    "u0trtMAZ": {
        "id": "u0trtMAZ",
        "title": "Utilization of Low Molecular Weight Heparin(LMWH) Anticoagulation in Treatment of Hemoperfusion",
        "authors": [
            {
                "name": "HUANG Xu-dong",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,the Renal Disease Research and Treatment Center of Beijing Military Area Command,Shijiazhuang ,China"
            },
            {
                "name": "ZHANG Li-xia",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,the Renal Disease Research and Treatment Center of Beijing Military Area Command,Shijiazhuang ,China"
            },
            {
                "name": "WANG Li-hui",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,the Renal Disease Research and Treatment Center of Beijing Military Area Command,Shijiazhuang ,China"
            },
            {
                "name": "WU Guang-li",
                "org": "Department of Nephrology,Bethune International Peace Hospital of PLA,the Renal Disease Research and Treatment Center of Beijing Military Area Command,Shijiazhuang ,China"
            }
        ],
        "venue": "clinical misdiagnosis & mistherapy",
        "keywords": [
            "Anticoagulation",
            "Heparin",
            "LMWH",
            "Hemoperfusion"
        ],
        "year": 2013
    },
    "t2nEEaZc": {
        "id": "t2nEEaZc",
        "title": "The role of endothelin-1 and angiotensin \u2161 in acute kidney injury due to over-exertion in rats",
        "authors": [
            {
                "name": "WU Guang-li",
                "org": ". Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "ZHANG Li-xia",
                "org": ". Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "ZHANG Wen-yu",
                "org": ". Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            },
            {
                "name": "HUANG Xu-dong",
                "org": ". Department of Nephrology, Bethune International Peace Hospital of PLA, Shijiazhuang , China"
            }
        ],
        "venue": "medical journal of chinese people's liberation army",
        "keywords": [
            "angiotensin \u2161",
            "kidney",
            "rats",
            "overtraining",
            "endothelins"
        ],
        "year": 2009
    },
    "06t0ilFd": {
        "authors": [
            {
                "name": "Xiaoping Wu",
                "org": ""
            },
            {
                "name": "Zhiping Liu",
                "org": ""
            },
            {
                "name": "Shiping Huang",
                "org": ""
            },
            {
                "name": "Wenchuan Wang",
                "org": ""
            }
        ],
        "title": "Molecular dynamics simulation of room-temperature ionic liquid mixture of [bmim][BF4] and acetonitrile by a refined force field",
        "abstract": "1-Butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF",
        "keywords": [
            ""
        ],
        "venue": "Physical Chemistry Chemical Physics",
        "year": 2005,
        "id": "06t0ilFd"
    },
    "ohICYsNO": {
        "id": "ohICYsNO",
        "title": "Synthesis, crystal structure and characterizations of a new 3D porous zinc phosphonate: Zn 6 [(O 3 PCH 2 ) 2 NHC 6 H 11 ] 4 \u00b76H 2 O",
        "abstract": "",
        "keywords": [
            "crystal structure",
            "zinc"
        ],
        "authors": [
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "lei meng",
                "org": ""
            },
            {
                "name": "zhengang sun",
                "org": ""
            },
            {
                "name": "zhongmin liu",
                "org": ""
            },
            {
                "name": "yan zhao",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "yanyu zhu",
                "org": ""
            },
            {
                "name": "xin lu",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "na zhang",
                "org": ""
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2008
    },
    "cFncBfez": {
        "id": "cFncBfez",
        "title": "Poly[sodium [\u03bc4\u20102\u2010hydroxyphosphonoacetato(3\u2212)]iron(II)]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing li",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yanyu zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "cuiying huang",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhengang sun",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "dapeng dong",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Acta Crystallographica Section E-structure Reports Online",
        "year": 2007
    },
    "SnsWeQRr": {
        "id": "SnsWeQRr",
        "title": "Synthesis, characterizations, and crystal structure of a novel layered phosphonate: Zn2Cl[O3PCH2N(CH2CH2)2O][O3PCH2NH(CH2CH2)2O]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "zhengang sun",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "yan zhao",
                "org": ""
            },
            {
                "name": "na zhang",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "xin lu",
                "org": ""
            },
            {
                "name": "yanyu zhu",
                "org": ""
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2009
    },
    "gt8TqSJA": {
        "id": "gt8TqSJA",
        "title": "Synthesis, crystal structure and characterizations of a novel lanthanide oxalatophosphonate with a 3D open-framework structure [Gd 2 {HO 3 PCH 2 NHCH 2 (CH 2 CH 2 OPO 2 )}(C 2 O 4 ) 2.5 (H 2 O) 2 ]\u00b75H 2 O",
        "abstract": "",
        "keywords": [
            "x ray diffraction",
            "single crystal",
            "crystal structure",
            "infrared spectroscopy",
            "thermogravimetric analysis"
        ],
        "authors": [
            {
                "name": "yan zhao",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "zhengang sun",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "yanyu zhu",
                "org": ""
            },
            {
                "name": "xin lu",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "na zhang",
                "org": ""
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2008
    },
    "JzzzsiDX": {
        "id": "JzzzsiDX",
        "title": "catena -Poly[[diaquanickel(II)]-\u03bc-2-hydroxyphosphonatoacetato]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "dapeng dong",
                "org": ""
            },
            {
                "name": "cuiying huang",
                "org": ""
            },
            {
                "name": "zhengang sun",
                "org": ""
            },
            {
                "name": "yanyu zhu",
                "org": ""
            }
        ],
        "venue": "Acta Crystallographica Section E-structure Reports Online",
        "year": 2007
    },
    "dgbNl3s3": {
        "id": "dgbNl3s3",
        "title": "Synthesis, characterizations, and crystal structure of a novel layered phosphonate: Zn 2 Cl[O 3 PCH 2 N(CH 2 CH 2 ) 2 O][O 3 PCH 2 NH(CH 2 CH 2 ) 2 O]",
        "abstract": "",
        "keywords": [
            "thermogravimetric analysis",
            "crystal structure",
            "x ray diffraction",
            "infrared spectroscopy",
            "single crystal",
            "double layer",
            "zinc"
        ],
        "authors": [
            {
                "name": "yanyu zhu",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "zhengang sun",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "yan zhao",
                "org": ""
            },
            {
                "name": "na zhang",
                "org": ""
            },
            {
                "name": "lei liu",
                "org": ""
            },
            {
                "name": "xin lu",
                "org": ""
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2009
    },
    "bqgelC6v": {
        "id": "bqgelC6v",
        "title": "catena\u2010Poly[[[aquacopper(II)]\u2010\u03bc\u20102\u2010(hydroxyphosphonato)acetato] dihydrate]",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing li",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "dapeng dong",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "yanyu zhu",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "zhengang sun",
                "org": "uc berkeley college of chemistry"
            },
            {
                "name": "hui chen",
                "org": "uc berkeley college of chemistry"
            }
        ],
        "venue": "Acta Crystallographica Section E-structure Reports Online",
        "year": 2007
    },
    "ZmKBwQhg": {
        "id": "ZmKBwQhg",
        "title": "Synthesis and characterizations of a layered antimony (III) phosphonate: [NH 2 CH 2 CH 2 NH 2 ][Sb 2 (O 3 PCH(OH)CO 2 ) 2 ]",
        "abstract": "",
        "keywords": [
            "thermogravimetric analysis",
            "single crystal",
            "crystal structure",
            "infrared spectroscopy",
            "x ray diffraction"
        ],
        "authors": [
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "lei meng",
                "org": ""
            },
            {
                "name": "zhengang sun",
                "org": ""
            },
            {
                "name": "lianyi cui",
                "org": ""
            },
            {
                "name": "jing zhang",
                "org": ""
            },
            {
                "name": "yanyu zhu",
                "org": ""
            },
            {
                "name": "dapeng dong",
                "org": ""
            },
            {
                "name": "hui chen",
                "org": ""
            },
            {
                "name": "wansheng you",
                "org": ""
            },
            {
                "name": "zaiming zhu",
                "org": ""
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2007
    },
    "ycOaJLlU": {
        "id": "ycOaJLlU",
        "title": "Synthesis, crystal structure, and thermal stability of a novel 3D cadmium carboxyphosphonate containing left-hand helical chains Cd 3 Cl 2 [(O 3 PCH 2 \u2013N(H)C 5 H 9 \u2013COO) 2 (H 2 O) 2 ]\u00b74H 2 O",
        "abstract": "",
        "keywords": [
            "crystal structure",
            "cadmium",
            "x ray diffraction",
            "infrared spectroscopy",
            "thermogravimetric analysis",
            "thermal stability",
            "single crystal"
        ],
        "authors": [
            {
                "name": "jing zhang",
                "org": "liaoning normal university"
            },
            {
                "name": "jing li",
                "org": "liaoning normal university"
            },
            {
                "name": "zhengang sun",
                "org": "liaoning normal university"
            },
            {
                "name": "ruinian hua",
                "org": "dalian nationalities university"
            },
            {
                "name": "yanyu zhu",
                "org": "liaoning normal university"
            },
            {
                "name": "yan zhao",
                "org": "liaoning normal university"
            },
            {
                "name": "na zhang",
                "org": "liaoning normal university"
            },
            {
                "name": "lei liu",
                "org": "liaoning normal university"
            },
            {
                "name": "xin lu",
                "org": "liaoning normal university"
            },
            {
                "name": "weinan wang",
                "org": "liaoning normal university"
            },
            {
                "name": "fei tong",
                "org": "liaoning normal university"
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2009
    },
    "RjiJkEXR": {
        "id": "RjiJkEXR",
        "title": "Synthesis and spectroscopic characterization of organophosphoryl tungstosilicates \u03b1 - [RP(O)] 2 SiW 11 O 39 4\u2212",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jingfu liu",
                "org": "liaoning normal university"
            },
            {
                "name": "wansheng you",
                "org": "liaoning normal university"
            },
            {
                "name": "zhengang sun",
                "org": "liaoning normal university"
            },
            {
                "name": "jing li",
                "org": "northeast normal university"
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2003
    },
    "3ZcbzuTj": {
        "id": "3ZcbzuTj",
        "title": "Synthesis and crystal structures of two new inorganic\u2013organic hybrid polyoxomolybdate complexes: [Himi] 4 [{Co(imi) 2 (H 2 O) 2 }Mo 7 O 24 ]\u00b74H 2 O and [Zn(imi) 4 ] 2 [(imi) 2 Mo 8 O 26 ]\u00b76H 2 O",
        "abstract": "",
        "keywords": [
            "zinc",
            "cobalt",
            "three dimensional",
            "crystal structure",
            "hydrogen bond",
            "aqueous solution"
        ],
        "authors": [
            {
                "name": "cuihua tian",
                "org": "faculty of chemistry"
            },
            {
                "name": "zhengang sun",
                "org": "faculty of chemistry"
            },
            {
                "name": "jing li",
                "org": "faculty of chemistry"
            },
            {
                "name": "xuefang zheng",
                "org": "dalian university of technology"
            },
            {
                "name": "haidong liang",
                "org": "faculty of chemistry"
            },
            {
                "name": "lancui zhang",
                "org": "faculty of chemistry"
            },
            {
                "name": "wansheng you",
                "org": "faculty of chemistry"
            },
            {
                "name": "zaiming zhu",
                "org": "faculty of chemistry"
            }
        ],
        "venue": "Inorganic Chemistry Communications",
        "year": 2007
    },
    "M0cEGpFJ": {
        "authors": [
            {
                "name": "Ting Yang",
                "org": "School of Computer Science and Engineering, University of Electronic Science and Technology of China"
            },
            {
                "name": "Qing Yang",
                "org": "Department of Computer Science, Montana State University"
            },
            {
                "name": "Yong Tang",
                "org": "School of Computer Science and Engineering, University of Electronic Science and Technology of China"
            }
        ],
        "title": "Random mobile agent based WSN model and its analysis",
        "abstract": "In order to optimize wireless sensor network coverage scheme, a random mobile agent-based wireless sensor network model (RMAWSN) is presented in this paper. The model uses swarm optimization algorithm to relocate active mobile agent for event detection. In this model, active mobile agent provides several advantages by the characteristics of random generation and movement: reducing active nodes in monitored area on the premise of coverage rate and the adaptation of divided or isolated network. Experiment results show that this model effectively improves network coverage and reduces consideration of communication distance.",
        "keywords": [
            "Coverage",
            "Mobile agent",
            "Swarm intelligence",
            "Wireless sensor network"
        ],
        "venue": "Dianzi Keji Daxue Xuebao/Journal of the University of Electronic Science and Technology of China",
        "year": 2015,
        "id": "M0cEGpFJ"
    },
    "LKw2YBVl": {
        "authors": [
            {
                "name": "Jun Huang",
                "org": "School of Communication and Information Engineering, Chongqing University of Posts and Telecommunications"
            },
            {
                "name": "Yunlong He",
                "org": "School of Communication and Information Engineering, Chongqing University of Posts and Telecommunications"
            },
            {
                "name": "Qiang Duan",
                "org": "Department of Information Sciences and Technology, Pennsylvania State University"
            },
            {
                "name": "Qing Yang",
                "org": "Department of Computer Science, Montana State University"
            },
            {
                "name": "Wei Wang",
                "org": "Department of Electrical Engineering and Computer Science, South Dakota State University"
            }
        ],
        "title": "Admission control with flow aggregation for QoS provisioning in software-defined network",
        "abstract": "Software Defined Network (SDN) may significantly enhance network and service management by enabling separated control and data planes. The centralized OpenFlow controller with a global vision of network states offers a promising approach to realizing flow-based admission control for supporting Quality of Service (QoS) provisioning in SDN. However, per-flow process brings in challenges to scalability of OpenFlow-based SDN. Flow aggregation has been explored as an effective method to address this issue. In this paper, we investigate admission control with flow aggregation for QoS provisioning in SDN. Specifically we propose a model for admission control with flow aggregation and develop the analysis techniques for determining the required amounts of bandwidth and buffer space at OpenFlow-enabled switches for meeting performance requirements in delay and packet loss. Network calculus is applied in our modeling and analysis; which makes our method applicable to general OpenFlow-based SDNs with various implementations. Numerical experiment results are also provided to evaluate effectiveness of the developed modeling and analysis techniques.",
        "keywords": [
            ""
        ],
        "venue": "2014 IEEE Global Communications Conference, GLOBECOM 2014",
        "year": 2015,
        "id": "LKw2YBVl"
    },
    "G9h9jTfh": {
        "authors": [
            {
                "name": "Yan-Ru Cao",
                "org": ""
            },
            {
                "name": "Xiu Chen",
                "org": ""
            },
            {
                "name": "Yi Jiang",
                "org": ""
            },
            {
                "name": "Li-Song Wang",
                "org": ""
            },
            {
                "name": "Cheng-Lin Jiang",
                "org": ""
            }
        ],
        "title": "Allokutzneria multivorans sp. nov., an actinomycete isolated from soil",
        "abstract": "An actinomycete with well-branched mycelia, designated strain YIM 120521",
        "keywords": [
            ""
        ],
        "venue": "International Journal of Systematic and Evolutionary Microbiology",
        "year": 2013,
        "id": "G9h9jTfh"
    },
    "ffj3uZIH": {
        "authors": [
            {
                "name": "Dao-Feng Zhang",
                "org": ""
            },
            {
                "name": "Xiu Chen",
                "org": ""
            },
            {
                "name": "Xiao-Mei Zhang",
                "org": ""
            },
            {
                "name": "Xiao-Yang Zhi",
                "org": ""
            },
            {
                "name": "Ji-Cheng Yao",
                "org": ""
            },
            {
                "name": "Yi Jiang",
                "org": ""
            },
            {
                "name": "Zhi Xiong",
                "org": ""
            },
            {
                "name": "Wen-Jun Li",
                "org": ""
            }
        ],
        "title": "Mycobacterium sediminis sp. nov. and Mycobacterium arabiense sp. nov., two rapidly growing members of the genus Mycobacterium",
        "abstract": "Two novel isolates of rapidly growing, Gram-stain-positive, non-chromogenic species of the genus Mycobacterium, strain YIM M13028",
        "keywords": [
            ""
        ],
        "venue": "International Journal of Systematic and Evolutionary Microbiology",
        "year": 2013,
        "id": "ffj3uZIH"
    },
    "aEERga79": {
        "authors": [
            {
                "name": "Gaiyun Zhang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Huihui Ren",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Xiu Chen",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Yubian Zhang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Yanliu Yang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Shuang Wang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            }
        ],
        "title": "Sporosarcina siberiensis sp. nov., isolated from the East Siberian Sea",
        "abstract": "A Gram-stain positive, non-motile, rod-shaped bacterium, designated strain 1111S-42",
        "keywords": [
            "Novel species",
            "Polyphasic taxonomy",
            "Sediment",
            "Sporosarcina siberiensis sp. nov."
        ],
        "venue": "Antonie van Leeuwenhoek, International Journal of General and Molecular Microbiology",
        "year": 2014,
        "id": "aEERga79"
    },
    "CkQK5NA3": {
        "authors": [
            {
                "name": "Pengfei Xie",
                "org": "Department of Chemistry"
            },
            {
                "name": "Ming Ma",
                "org": "Department of Chemistry"
            },
            {
                "name": "Mostafa E. Rateb",
                "org": "Department of Chemistry"
            },
            {
                "name": "Khaled A. Shaaban",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zhiguo Yu",
                "org": "Department of Chemistry"
            },
            {
                "name": "Sheng-Xiong Huang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Li-Xing Zhao",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Xiangcheng Zhu",
                "org": "Xiangya International Academy of Translational Medicine"
            },
            {
                "name": "Yijun Yan",
                "org": "Department of Chemistry"
            },
            {
                "name": "Ryan M. Peterson",
                "org": "Division of Pharmaceutical Sciences"
            },
            {
                "name": "Jeremy R. Lohman",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dong Yang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Min Yin",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jeffrey D. Rudolf",
                "org": "Department of Chemistry"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Yanwen Duan",
                "org": "Xiangya International Academy of Translational Medicine"
            },
            {
                "name": "Ben Shen",
                "org": "Natural Products Library Initiative"
            }
        ],
        "title": "Biosynthetic potential-based strain prioritization for natural product discovery: A showcase for diterpenoid-producing actinomycetes",
        "abstract": "Natural products remain the best sources of drugs and drug leads and serve as outstanding small-molecule probes to dissect fundamental biological processes. A great challenge for the natural product community is to discover novel natural products efficiently and cost effectively. Here we report the development of a practical method to survey biosynthetic potential in microorganisms, thereby identifying the most promising strains and prioritizing them for natural product discovery. Central to our approach is the innovative preparation, by a two-tiered PCR method, of a pool of pathway-specific probes, thereby allowing the survey of all variants of the biosynthetic machineries for the targeted class of natural products. The utility of the method was demonstrated by surveying 100 strains, randomly selected from our actinomycete collection, for their biosynthetic potential of four classes of natural products, aromatic polyketides, reduced polyketides, nonribosomal peptides, and diterpenoids, identifying 16 talented strains. One of the talented strains, Streptomyces griseus CB00830, was finally chosen to showcase the discovery of the targeted classes of natural products, resulting in the isolation of three diterpenoids, six nonribosomal peptides and related metabolites, and three polyketides. Variations of this method should be applicable to the discovery of other classes of natural products. \u00a9 2014 The American Chemical Society and American Society of Pharmacognosy.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Natural Products",
        "year": 2014,
        "id": "CkQK5NA3"
    },
    "IqQFqoOq": {
        "authors": [
            {
                "name": "Gaiyun Zhang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Huihui Ren",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Shuang Wang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Xiu Chen",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Yanliu Yang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Yubian Zhang",
                "org": "Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            }
        ],
        "title": "Janibacter indicus sp. nov., isolated from hydrothermal sediment of the Indian Ocean",
        "abstract": "A Gram-staining-positive, aerobic and non-motile strain, 0704P10-1",
        "keywords": [
            ""
        ],
        "venue": "International Journal of Systematic and Evolutionary Microbiology",
        "year": 2014,
        "id": "IqQFqoOq"
    },
    "bCOJtSqQ": {
        "authors": [
            {
                "name": "Hindra",
                "org": "Department of Chemistry"
            },
            {
                "name": "Tingting Huang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dong Yang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jeffrey D. Rudolf",
                "org": "Department of Chemistry"
            },
            {
                "name": "Pengfei Xie",
                "org": "Department of Chemistry"
            },
            {
                "name": "Guangbo Xie",
                "org": "Department of Chemistry"
            },
            {
                "name": "Qihui Teng",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jeremy R. Lohman",
                "org": "Department of Chemistry"
            },
            {
                "name": "Xiangcheng Zhu",
                "org": "Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery"
            },
            {
                "name": "Yong Huang",
                "org": "Xiangya International Academy of Translational Medicine, Central South University"
            },
            {
                "name": "Li-Xing Zhao",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Yanwen Duan",
                "org": "Hunan Engineering Research Center of Combinatorial Biosynthesis and Natural Product Drug Discovery"
            },
            {
                "name": "Ben Shen",
                "org": "Natural Products Library Initiative, Scripps Research Institute"
            }
        ],
        "title": "Strain prioritization for natural product discovery by a high-throughput real-time PCR Method",
        "abstract": "Natural products offer unmatched chemical and structural diversity compared to other small-molecule libraries, but traditional natural product discovery programs are not sustainable, demanding too much time, effort, and resources. Here we report a strain prioritization method for natural product discovery. Central to the method is the application of real-time PCR, targeting genes characteristic to the biosynthetic machinery of natural products with distinct scaffolds in a high-throughput format. The practicality and effectiveness of the method were showcased by prioritizing 1911 actinomycete strains for diterpenoid discovery. A total of 488 potential diterpenoid producers were identified, among which six were confirmed as platensimycin and platencin dual producers and one as a viguiepinol and oxaloterpin producer. While the method as described is most appropriate to prioritize strains for discovering specific natural products, variations of this method should be applicable to the discovery of other classes of natural products. Applications of genome sequencing and genome mining to the high-priority strains could essentially eliminate the chance elements from traditional discovery programs and fundamentally change how natural products are discovered.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Natural Products",
        "year": 2014,
        "id": "bCOJtSqQ"
    },
    "dk3YUUU5": {
        "authors": [
            {
                "name": "Yang Feng",
                "org": "Institute of Environmental Science and Ecological Restoration"
            },
            {
                "name": "Xuexiu Chang",
                "org": "Institute of Environmental Science and Ecological Restoration"
            },
            {
                "name": "Lixing Zhao",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Xiuping Li",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Wenjun Li",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology"
            }
        ],
        "title": "Nanaomycin A methyl ester, an actinomycete metabolite: Algicidal activity and the physiological response of Microcystis aeruginosa",
        "abstract": "Harmful cyanobacterial blooms and their negative impacts on water ecosystems and human health have been reported all over the world, and Microcystis aeruginosa is one of the most dominant and ecologically damaging species in eutrophic lakes such as Dianchi Lake and Taihu Lake in China. Although physical or chemical control of the blooms is possible in short period, these methods could cause other problems. Thus, there is still a need for research on biological factors controlling cyanobacteria blooms. We screened part of the Yunnan University actinomycete strain library and found that the extract of Streptomyces hebeiensis YIM 001",
        "keywords": [
            "Actinomycete metabolite",
            "Flow cytometry",
            "Microcystis aeruginosa inhibition",
            "Nanaomycin A methyl ester (NAME)",
            "Physiological response"
        ],
        "venue": "Ecological Engineering",
        "year": 2013,
        "id": "dk3YUUU5"
    },
    "xMR96eZN": {
        "authors": [
            {
                "name": "Dan Zheng",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            },
            {
                "name": "Li Han",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Yan-Ru Cao",
                "org": "Department of Life Science and Technology"
            },
            {
                "name": "Jiang Liu",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            },
            {
                "name": "Xiu Chen",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Yi-Qing Li",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Xue-Shi Huang",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            }
        ],
        "title": "Structure elucidation of four prenylindole derivatives from Streptomyces sp. isolated from Ailuropoda melanoleuca feces",
        "abstract": "Four new prenylindole derivatives, (R)-6-(2,3-dihydroxy-3-methylbutyl) indole (1), (R)-6-(2,3-dihydroxy-3-methylbutyl)indolin-2-one (2), and an unseparated mixture of (Z)-6-(4-hydroxy-3-methylbut-2-en-1-yl)indolin-2-one (3a) and (E)-6-(4-hydroxy-3-methylbut-2-en-1-yl)indolin-2-one (3b) with a ratio of 3: 2, were isolated from the culture broth of a streptomycete isolated from Ailuropoda melanoleuca feces. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic techniques. The absolute configuration of 1 was determined by Mosher's method. Copyright \u00a9 2013 John Wiley & Sons, Ltd.",
        "keywords": [
            "2D NMR",
            "13C NMR",
            "1H NMR",
            "Ailuropoda melanoleuca",
            "NMR",
            "prenylindole derivatives",
            "Streptomyces sp"
        ],
        "venue": "Magnetic Resonance in Chemistry",
        "year": 2013,
        "id": "xMR96eZN"
    },
    "Dr2tCbut": {
        "authors": [
            {
                "name": "Hangxian Lai",
                "org": "College of Natural Resources and Environment, Northwest A and F University"
            },
            {
                "name": "Xiaomin Wei",
                "org": "College of Natural Resources and Environment, Northwest A and F University"
            },
            {
                "name": "Yingying Jiang",
                "org": "College of Natural Resources and Environment, Northwest A and F University"
            },
            {
                "name": "Xiu Chen",
                "org": "Yunnan Institute of Microbiology and Life Sciences Lab Center, Yunnan University"
            },
            {
                "name": "Qinyuan Li",
                "org": "Yunnan Institute of Microbiology and Life Sciences Lab Center, Yunnan University"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology and Life Sciences Lab Center, Yunnan University"
            },
            {
                "name": "Chenglin Jiang",
                "org": "Yunnan Institute of Microbiology and Life Sciences Lab Center, Yunnan University"
            },
            {
                "name": "Leionid Gillerman",
                "org": "J. Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev"
            }
        ],
        "title": "Halopolyspora alba gen. nov., sp. nov., isolated from sediment",
        "abstract": "A novel halophilic, filamentous actinomycete, designated strain AFM 10251",
        "keywords": [
            ""
        ],
        "venue": "International Journal of Systematic and Evolutionary Microbiology",
        "year": 2014,
        "id": "Dr2tCbut"
    },
    "BcTXfmo0": {
        "authors": [
            {
                "name": "Jiaoyue Zhang",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Yanru Cao",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Jiang Liu",
                "org": "Institute of Microbial Pharmaceuticals"
            },
            {
                "name": "Dan Zheng",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            },
            {
                "name": "Xiu Chen",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Li Han",
                "org": "Institute of Microbial Pharmaceuticals"
            },
            {
                "name": "Chenglin Jiang",
                "org": "Institute of Microbial Pharmaceuticals"
            },
            {
                "name": "Xueshi Huang",
                "org": "Laboratory of Metabolic Disease Research and Drug Development"
            }
        ],
        "title": "Violapyrones A-G, \u03b1-pyrone derivatives from Streptomyces violascens isolated from Hylobates hoolock feces",
        "abstract": "Seven new 3,4,6-trisubstituted \u03b1-pyrone derivatives, violapyrones A-G (1-7), were isolated from Streptomyces violascens obtained from Hylobates hoolock feces. Their structures were elucidated on the basis of detailed spectroscopic analysis. The antimicrobial activities of 1-7 were evaluated against Gram-positive and Gram-negative bacteria and against fungi. Compounds 1-3 showed moderate antibacterial activities against Bacillus subtilis and Staphylococcus aureus with MIC values of 4-32 \u03bcg/mL. \u00a9 2013 The American Chemical Society and American Society of Pharmacognosy.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Natural Products",
        "year": 2013,
        "id": "BcTXfmo0"
    },
    "hYdnblfb": {
        "authors": [
            {
                "name": "Li Han",
                "org": "Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University"
            },
            {
                "name": "Peiyuan Huo",
                "org": "North China Pharmaceutical Group Corporation New Drug Research and Development Co., Ltd."
            },
            {
                "name": "Huahong Chen",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Songtao Li",
                "org": "Laboratory of Metabolic Disease Research and Drug Development, China Medical University"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Liya Li",
                "org": "Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University"
            },
            {
                "name": "Lihua Xu",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Chenglin Jiang",
                "org": "Yunnan Institute of Microbiology, Yunnan University"
            },
            {
                "name": "Xueshi Huang",
                "org": "Laboratory of Metabolic Disease Research and Drug Development, China Medical University"
            }
        ],
        "title": "New derivatives of nonactic and homononactic acids from Bacillus pumilus derived from Breynia fruticosa",
        "abstract": "Six new nonactic and homononactic acid derivatives, ethyl homononactate (1), ethyl nonactate (2), homononactyl homononactate (6), ethyl homononactyl nonactate (7), ethyl homononactyl homononactate (8), and ethyl nonactyl nonactate (9), as well as four known compounds, homononactic acid (3), nonactic acid (4), homononactyl nonactate (5), and bishomononactic acid (10), were isolated from culture broth of Bacillus pumilus derived from Breynia fruticosa. The structures of new compounds were elucidated by spectroscopic analysis and chemical methods. The optical purities of 1-6 were determined by HPLC/MS after treatment with L-phenylalanine methyl ester. The dimeric compounds 5-9 showed weak cytotoxic activities against five human cancer cell lines (IC",
        "keywords": [
            "Bacillus pumilus",
            "Breynia fruticosa",
            "Cytotoxic activity",
            "Homononactic acid derivatives",
            "Nonactic acid derivatives"
        ],
        "venue": "Chemistry and Biodiversity",
        "year": 2014,
        "id": "hYdnblfb"
    },
    "OgcXoWC0": {
        "authors": [
            {
                "name": "Brad Tebbets",
                "org": "Department of Medical Microbiology and Immunology"
            },
            {
                "name": "Zhiguo Yu",
                "org": "Department of Chemistry"
            },
            {
                "name": "Douglas Stewart",
                "org": "Department of Pediatrics"
            },
            {
                "name": "Li-Xing Zhao",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Yi Jiang",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "Li-Hua Xu",
                "org": "Yunnan Institute of Microbiology"
            },
            {
                "name": "David Andes",
                "org": "Department of Internal Medicine"
            },
            {
                "name": "Ben Shen",
                "org": "Department of Molecular Therapeutics"
            },
            {
                "name": "Bruce Klein",
                "org": "Department of Internal Medicine"
            }
        ],
        "title": "Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: Insights into macrotetrolide drug spectrum, potency and mode of action",
        "abstract": "Since current antifungal drugs have not kept pace with the escalating medical demands of fungal infections, new, effective medications are required. However, antifungal drug discovery is hindered by the evolutionary similarity of mammalian and fungal cells, which results in fungal drug targets having human homologs and drug non-selectivity. The group III hybrid histidine kinases (HHKs) are an attractive drug target since they are conserved in fungi and absent in mammals. We used a Saccharomyces cerevisiae reporter strain that conditionally expresses HHK to establish a high-throughput bioassay to screen microbial extracts natural products for antifungals. We identified macrotetrolides, a group of related ionophores thought to exhibit restricted antifungal activity. In addition to confirming the use of this bioassay for the discovery of antifungal natural products, we demonstrated broader, more potent fungistatic activity of the macrotetrolides against multiple Candida spp., Cryptococcus spp., and Candida albicans in biofilms. Macrotetrolides were also active in an animal model of C. albicans biofilm, but were found to have inconsistent activity against fluconazole-resistant C. albicans, with most isolates resistant to this natural product. The macrotetrolides do not directly target HHKs, but their selective activity against S. cerevisiae grown in galactose (regardless of Drk1 expression) revealed potential new insight into the role of ion transport in the mode of action of these promising antifungal compounds. Thus, this simple, high-throughput bioassay permitted us to screen microbial extracts, identify natural products as antifungal drugs, and expand our understanding of the activity of macrotetrolides. \u00a9 2013 ISHAM.",
        "keywords": [
            "Drug discovery",
            "Fungi",
            "Macrotetrolide",
            "Natural products",
            "Reporter"
        ],
        "venue": "Medical Mycology",
        "year": 2013,
        "id": "OgcXoWC0"
    },
    "cwClKdjZ": {
        "id": "cwClKdjZ",
        "title": "Photonic generation of MMW-UWB monocycle and doublet signals based on frequency up-conversion and delay-line filter",
        "abstract": "Abstract   A photonic approach to generate millimeter-wave (MMW) ultra-wideband (UWB) monocycle and doublet signals using stimulated Brillouin scattering (SBS) selective sideband amplification technique and delay-line filter is proposed and theoretically analyzed. In the proposed approach, a dual-drive Mach\u2013Zehnder modulator (DDMZM) is used as a first-order differentiator to produce a monocycle UWB signal. Then the generated monocycle signal is single-sideband (SSB) modulated by SBS effect for up-conversion. A balanced photodetector (BPD) is further employed for both photodetection and first-order differentiation. Consequently, an MMW-UWB monocycle signal or an MMW-UWB doublet signal can be attained in electrical field with controlling an optical switch. The frequency spectra of the generated MMW-UWB monocycle and doublet signals meet well with the Federal Communication Committee (FCC) mask with power efficiency of 50.63% and 40.53%. Besides, the produced MMW-UWB signals can be employed to realize multiple modulation formats, such as on-off keying modulation (OOK), pulse position modulation (PPM) and pulse amplitude modulation (PAM).",
        "keywords": "",
        "authors": [
            {
                "name": "Cong Du",
                "org": "State Key Laboratory on Integrated Optoelectronics, college of electronic science & engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, China"
            },
            {
                "name": "Xiang Li",
                "org": "State Key Laboratory on Integrated Optoelectronics, college of electronic science & engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, China"
            },
            {
                "name": "Di Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, college of electronic science & engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, China"
            },
            {
                "name": "Wei Dong",
                "org": "State Key Laboratory on Integrated Optoelectronics, college of electronic science & engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, China"
            },
            {
                "name": "Xindong Zhang",
                "org": "State Key Laboratory on Integrated Optoelectronics, college of electronic science & engineering, Jilin University, 2699 Qianjin Street, Changchun, 130012, China"
            }
        ],
        "venue": "Optics Communications",
        "year": 2019
    },
    "QfHaKtLu": {
        "id": "QfHaKtLu",
        "title": "Instantaneous microwave frequency measurement with high-resolution based on stimulated Brillouin scattering",
        "abstract": "Abstract   A novel photonic method of instantaneous microwave frequency measurement (IMFM) based on Stimulated Brillouin scattering (SBS) is proposed. The principle of the technique is the employment of SBS effect to amplify/attenuate two adjacent frequency components, which result in a definite amplitude comparison function (ACF). Using this technique, the frequency of an unknown RF signal can be precisely obtained. Experimental results show the measurement capability of the proposed method over a frequency range of 0.47\u201323\u202fGHz with a higher resolution of 8\u202fMHz.",
        "keywords": "",
        "authors": [
            {
                "name": "Di Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Linbing Pan",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Yue Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Qi Zhang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Cong Du",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Kongjia Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Wei Dong",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            },
            {
                "name": "Xindong Zhang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China"
            }
        ],
        "venue": "Optics and Laser Technology",
        "year": 2019
    },
    "EILEYiH7": {
        "id": "EILEYiH7",
        "title": "Photonic millimeter-wave ultrawideband signal generation using frequency upconversion based on the stimulated Brillouin scattering effect.",
        "abstract": "We present a novel and simple scheme for photonic generation of a millimeter-wave ultrawideband (UWB) signal free of low-frequency components that is implemented by using a stimulated Brillouin scattering (SBS)-based frequency-doubling method. A dual-parallel Mach-Zehnder modulator is incorporated to generate appropriate optical sidebands and an optical carrier carrying the UWB signal. Then the single-sideband modulation is realized based on the successive SBS frequency shifting process. Eventually, a UWB signal is upconverted to twice the frequency of the radio frequency signal. To vindicate the feasibility of the proposed scheme, an experiment is carried out, and it turns out that a UWB signal with a bandwidth of 7\u00a0GHz is upconverted to 21.75\u00a0GHz. The spectrum of the generated signal meets well with the Federal Communications Commission mask.",
        "keywords": "",
        "authors": [
            {
                "name": "Cong Du",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Weinan Zhou",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Yue Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Minghai Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Di Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Kongjia Wang",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Wei Dong",
                "org": "State Key Laboratory on Integrated Optoelectronics, College of Electronic Science & Engineering, Jilin University, Changchun 130012, China"
            },
            {
                "name": "Xindong Zhang",
                "org": "e-mail: xindong@jlu.edu.cn"
            }
        ],
        "venue": "Optics letters",
        "year": 2018
    },
    "6o21uL0B": {
        "id": "6o21uL0B",
        "title": "Wideband tunable up-converting optoelectronic oscillator based on gain\u2013loss compensation technology and stimulated Brillouin scattering",
        "abstract": "An optically wideband tunable up-converting optoelectronic oscillator (OEO) based on stimulated Brillouin scattering and gain\u2013loss compensation is demonstrated and theoretically analyzed. In the proposed structure, Brillouin narrowband filter technique is implemented by introducing two pump lights with the frequency interval twice the Brillouin frequency shift (vb). The overlapping of the gain and the loss spectrum is used to realize a wideband tunable OEO. As a consequence, the tunability of the wideband of the output microwave signal at (f_{m} + 2v_{b}) from 22.4 to 61.4 GHz can be realized by changing the signal under testing from 1 to 40 GHz. In addition, the transfer function of the system is given and the single sideband (SSB) phase noise is also evaluated theoretically. And the theoretical simulated the SSB phase noise is \u2212 116.1 dBc/Hz at the 10 kHz offset when the fm = 25 GHz. Not only the OEO can convert a low-frequency IF signal to a high-frequency signal without introducing any high-Q electrical filter, but the frequency of the output signal is high enough and widely tunable. Because of the high frequency tunable capacity, the up-converting OEO might have a potential application in radar communication and millimeter wave generation systems.",
        "keywords": "",
        "authors": [
            {
                "name": "Yue Wang",
                "org": "Jilin University"
            },
            {
                "name": "Yikun Shan",
                "org": "Jilin University"
            },
            {
                "name": "Cong Du",
                "org": "Jilin University"
            },
            {
                "name": "Yucheng Li",
                "org": "Jilin University"
            },
            {
                "name": "Yubing Wang",
                "org": "Jilin University"
            },
            {
                "name": "Di Wang",
                "org": "Jilin University"
            },
            {
                "name": "Wei Dong",
                "org": "Jilin University"
            },
            {
                "name": "Xindong Zhang",
                "org": "Jilin University"
            }
        ],
        "venue": "Optical and Quantum Electronics",
        "year": 2019
    },
    "bxxeTqvJ": {
        "id": "bxxeTqvJ",
        "title": "Triple frequency- and phase-tunable optoelectronic oscillator based on stimulated Brillouin scattering and carrier phase-shifted single sideband modulation",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yue Wang",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            },
            {
                "name": "Cong Du",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            },
            {
                "name": "Weinan Zhou",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            },
            {
                "name": "Di Wang",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            },
            {
                "name": "Kongjia Wang",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            },
            {
                "name": "Wei Dong",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            },
            {
                "name": "Xindong Zhang",
                "org": "Jilin University, College of Electronic Science and Engineering, State Key Laboratory on Integrated"
            }
        ],
        "venue": "Optical Engineering",
        "year": 2019
    },
    "gv3dFFyU": {
        "authors": [
            {
                "name": "Miaohong Wu",
                "org": "College of Biological Science and Engineering, Fuzhou University"
            },
            {
                "name": "Qingyan He",
                "org": "College of Biological Science and Engineering, Fuzhou University"
            },
            {
                "name": "Yongxiang Hong",
                "org": "College of Biological Science and Engineering, Fuzhou University"
            },
            {
                "name": "Hong Zhou",
                "org": "Fujian Sunner Food Limited Company"
            },
            {
                "name": "Ming Chen",
                "org": "Fujian Sunner Food Limited Company"
            },
            {
                "name": "Shaoyun Wang",
                "org": "College of Biological Science and Engineering, Fuzhou University"
            }
        ],
        "title": "Preparation of new type chicken meatballs by tgase-induced crosslinking of plant and animal heterologous proteins",
        "abstract": "objective: This essay was to study the optimum condition to produce new type chicken meatball. In order to obtain the best quality of chicken meatball, the crosslinking of chicken protein and kidney bean protein was used. Methods: The crosslinking conditions were screened and optimized using single-factor test and response surface methodology according to the criteria of hardness level. Result: The TGase concentration, reaction time and reaction temperature have significant effects on the gel hardness of the chicken meatball, concentration and heated temperature of kidney bean protein also have effect on the gel hardness of chicken meatball. The optimum conditions were as follows: TGase concentration 0.24%, reaction time 65.62 min, reaction temperature 43.63\u2103, kidney bean protein concentration 1.5%, the gel hardness of chicken meatball was 681.062 g. Conclusion; The addition of TG improve the quality of chicken meatball obviously, which is of practical significance for the production application.",
        "keywords": [
            "Chicken meatballs",
            "Hardness",
            "Kidney bean protein",
            "RSM",
            "TGase"
        ],
        "venue": "Journal of Chinese Institute of Food Science and Technology",
        "year": 2015,
        "id": "gv3dFFyU"
    },
    "vHCkp3U5": {
        "id": "vHCkp3U5",
        "title": "A high fluorescence rate is key for stable blue organic light-emitting diodes",
        "abstract": "Singlet\u2013singlet exciton annihilation (SSA) is found to be a critical factor for the decomposition of blue thermally activated delayed fluorescence (TADF) emitters in organic light-emitting diodes (OLEDs). Since radiative decay is a competitive process against bimolecular SSA, increasing the fluorescence rate (kF) of the blue TADF emitters can significantly prolong the deviceu0027s operational lifetime by reducing the singlet exciton concentration at a given luminance level.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhusen Liu",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Fangyi Cao",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Taiju Tsuboi",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Yan Yue",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Chao Deng",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Xufeng Ni",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Weilin Sun",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,P. R. China"
            },
            {
                "name": "Qisheng Zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Materials Chemistry C",
        "year": 2018
    },
    "l09dFIPv": {
        "id": "l09dFIPv",
        "title": "A novel serial high frequency surface acoustic wave humidity sensor",
        "abstract": "A novel topology of surface acoustic wave (SAW) humidity sensor was proposed. An interdigital electrode (IDE) was added in serial with a SAW resonator (SAWR) as the sensitive component. Silicon-containing polyelectrolyte humidity sensitive film was deposited on the surface of IDE instead of SAWR. By this way, the stringent technical requirements for film coating on SAW surface could be avoided, which was helpful to bring down the processing cost of the sensor. At the same time, vacuum packaged SAWR could provide a more stable and high operating frequency (433 MHz) for the sensor, which was profitable for both stability and sensitivity of the sensor. Sensitivity, stability, response-time, temperature coefficient of the novel sensor were tested and compared with the traditional SAWR sensor in our previous work. The results showed that both sensitivity (0.4 kHz/%RH at low humidity level; >1 kHz at high humidity level) and stability (noise level <10 Hz) of the sensor have got remarkable improvement for the new design. Keywords Humidity sensor Surface acoustic wave Interdigital electrode Series Polyelectrolyte 1 Introduction A strong need exists for developing accurate, cheap and reliable sensors to measure relative humidity (RH) in different ambient for practical applications in the fields of meteorology, medicine, comfort, agriculture, process control. Generally, a RH sensor has to match stringent working requirements such as high sensitivity, speed of response, reliability, stability, low cost, small size and weight, ease-to-manufacture, ease-to-use, mass production [1] . An effective SAW humidity sensor using electrosprayed silicon-containing polyelectrolyte film as humidity sensitive film was developed in our early research [2] . Although it had already got an excellent performance, some problems were still found in further study. First, the dimension of SAW resonators (SAWR) and thereby the length of the film, usually decreased as the operating frequency became higher. An increase in frequency is profitable for a high resolution, but the film length decrease is not [3] . Second, there are many stringent requirements for depositing sensitive film onto surface of SAW devices with high frequency due to its small size and special properties [4] . Both thickness and discreteness of the film must be accurately controlled [5] . The over-thick film will increase transmission attenuation of the SAW, and so will the film with a poor discreteness. The requirements for precision filming instrument and technique will greatly increase processing cost of the sensor, which is contrary to the demand for an ideal humidity sensor. Furthermore, until now, the repeatability of this coating method is still not comfortable for mass production. Third, due to dissociation effect of the polyelectrolyte film, IDT and reflectors of SAWR may be shorted by conductive ions, especially at high humidity level. At last, the Aluminum (Al) strips on the substrate were very prone to be corroded when exposed in high humidity ambience, which will make a negative influence on the lifespan and stability of the sensor. In order to solve all the problems above, a gold interdigital electrode (IDE) was added in series with original SAWR to form a new sensing topology. By this way, the humidity sensitive film could be directly deposited on surface of the IDE instead of SAWR. Compared to SAWR, coating method for IDE has much better controllability and repeatability, and then the requirements for coating equipment and technique would be much lower. This will greatly reduce the sensors\u2019 processing cost and make it more proper for mass production. At the same time, SAWR could be vacuum packaged to be prevented from corrosion and perturbation. This could provide a more stable basic operating frequency of the sensor to improve its stability and to extend its lifespan. Furthermore, the new sensitive mechanism is profitable for an increase of the sensitivity. Topological structure of the sensor was similar to the one proposed by Yao used in various bioanalytical fields [6] . The difference was that SAWR was used to take the place of quartz crystal. SAWR can provide a higher operating frequency of the sensor to improve its sensitivity and make it more suitable for wireless applications at the same time. The similar structure using for humidity detection has never been reported before. 2 Model and principle In the previous design, SAWR was used as the humidity sensing component. In humidity detection circuit, it was used as frequency selective component to form a positive feedback oscillating circuit with other discrete components. Its equivalent circuit was displayed in Fig. 1 (a) . C 0 is the shunt static capacitance, L s , C s and R s are motional inductance, motional capacitance, and motional resistance respectively. In the new topological structure, a gold IDE was added in serial with SAWR, the new equivalent circuit was showed in Fig. 1 (b). C e and R e are the equivalent capacity and resistor of the IDE respectively. The SAWR and IDE were connected in series to form a new frequency selective network. Its resonance frequency F is determined by Eq. (1) as follows: (1) F = F o 1 + \u03c0 F o C s ( 2 \u03c0 F o C e \u2212 Y G e ) G e 2 \u2212 2 \u03c0 F o C o G e Y + 4 \u03c0 2 F o 2 C e ( C o + C e ) \u2212 \u03c0 F o C s R s Y In Eq. (1) , F o = 1 / 2 \u03c0 L s C s is the basic operating frequency of the sensor determined by SAWR. Y is a phase parameter of the amplifier circuit. G e = 1/ R e is surface conductance of the IDE. Interelectrode capacitance C e = k\u025b + C p , among which \u025b is dielectric constant and C p is the parasitic capacitance between connection wires. For this new design, because SAWR was vacuum packaged, its equivalent parameter could keep stable under different humidity conditions. Different to the previous design using SAWR as sensitive component, resonance frequency of the new topology was mainly determined by G e and \u025b of the IDE. So the conductive humidity sensing materials, such as polyelectrolyte or some inorganic electrolyte, are more suitable for the new design. When absorbing water vapors, ion interaction in the film became weaker, instead, ion migration rate turned stronger. Under different humidity conditions, the film would dissociate out different amount of conductive ions, which would then lead to a different variance of G e and \u025b of the IDE. Finally, a different resonance frequency F could be got, by measuring which different ambient humidity can be detected. Another remarkable bene\ufb01t of the new structure was to avoid the dif\ufb01culty for measuring a large resistance of the IDE, which often larger than 10 7 ohm at relative low humidity condition. 3 Experiment 3.1 Device The same 433 MHz SAWR as in [2] was used in this design too. ST-cut quartz was chosen as the substrate to avoid temperature interference. It was vacuum packaged by a metal shell with drawn vacuum inside (as shown in Fig. 2 ). In the serial topology, SAWR was used to provide the basic operating frequency for the sensor. When vacuum packaged, it could provide a more stable basic frequency to improve the sensor's stability. At the same time, the sensor's lifespan could be extended by this method. A gold IDE was chosen as the sensitive component, which had been widely used in gas detection due to its low cost and simple fabrication process [7] . 13 pairs of fingers were sputtered onto ceramic substrate, whose width and interval were both 40um. Structure schematic of the IDE was showed in Fig. 3 . The area for film coating was about 4 mm \u00d7 4 mm, which was much larger than on the high frequency SAWR (1 mm \u00d7 3 mm). Its relatively large coating area and facility for operation would bring down the processing cost to a great degree. 3.2 Coating preparation Silicon-containing polyelectrolyte was used as humidity sensitive material. Prepolymer with different concentration, 25 mg/ml, 50 mg/ml and 100 mg/ml, were prepared with the same method proposed in [2] . Prepolymer was then deposited on IDE surface by dip coating method, which has much easier operability and lower cost compared to the electrospray method used in previous design. After heated at 110 \u00b0C for 10 h, the prepolymer would polymerize on the substrate with Si\u2013O bond, as shown in Fig. 4 . In this material, quaternary ammonium salt is hydrophilic group, and the Si\u2013O group is hydrophobic group. This special structure could provide a good balance of hydrophilic and hydrophobic characteristic of the material. So it has excellent water vapor desorption\u2013absorption properties, which can ensure the sensor has a wonderful dynamic performance. 3.3 Testing instrumentation A positive feedback oscillation circuit (as shown in Fig. 5 ) was made up to generate an oscillator signal, whose frequency was affected by the ambient moisture content. By measuring the output signal, ambient humidity could be got. In order to avoid influence by other factors, a dual-channel mixer was used. One electrode coated with humidity sensitive film was used in the sensitive channel; the other with no film was used in reference channel. The sensitive module was hung in the widemouth container with different humidity generated by different saturated salt solution. Its output signal was connected to mixer by a special shielded cable, and then mixed with the reference signal. The mixed signal was then filtered and shaped to regular pulse wave, which was counted by a microprocessor after 16-order division. The whole detect system was displayed in Fig. 6 . 4 Results and discussion 4.1 Sensitivity Experiment was carried out at normal pressure and temperature conditions (23 \u00b1 1 \u00b0C and 1 atm.). Different saturated salt solution were prepared in different containers to obtain different humidity used in the test, that is, LiCl for 11%RH, MgCl 2 for 33%RH, NaBr for 59%RH, NaCl for 75%RH and K 2 SO 4 for 97%RH. Sensitivity of the three sensors coated by the prepolymer with different concentration (25 mg/ml, 50 mg/ml, and 100 mg/ml) was tested. The output frequency at different humidity was present in Fig. 7 . Because all the three sensors had a similar operating frequency, the frequency variance at different humidity could directly reflect the sensor's sensitivity. In order to make an obvious comparison, the value of frequency shift from 11% RH point (frequency at 11% RH was used as \u201c0\u201d point) was used as the ordinate axis in both Figs. 7 and 8 . As shown in Fig. 7 , for each sensor, the output mixed frequency increased with the same trend of ambient humidity. This was because the quaternary ammonium salt contained in the sensing film could release free ions through dissociation effect when absorbing water vapors. The film with higher concentration could absorb more water molecules, dissociate out more free conductive ions, and at last generate a larger variance of the conductivity. So the frequency shift became more obvious when coated by prepolymer with higher concentration. As dissociation ability became stronger when humidity increased, the sensitivity became larger at higher humidity level for all the three sensors. The response curve was not linear but approximate to a quadratic curve. As a conclusion, with regard to sensitivity, the materials with strong conductive ability and large conductivity variance when absorbing water vapors were much suitable for the new design. A further experiment was done to compare the new design with previous SAWR sensor. Prepolymer concentration of the two sensors was both 50 mg/ml. An obvious improvement in sensitivity could be seen in Fig. 8 . For the new sensor, sensitivity at low humidity level (<30%RH) was about 0.4 kHz/%RH, which was only a little larger than the previous sensor. However, at relatively higher humidity level, the sensitivity raised to above 1 kHz/%RH, which was a remarkable improvement compared to the previous one. This was because that in the new circuit topology, resonant frequency was much more sensitive to the conductivity variance of the film but not to the load effect as in the previous SAWR sensor. For polyelectrolyte material, when absorbing water vapors, its conductivity variance was much more remarkable than its mass variance. At higher humidity level, the difference was much more obvious. So the sensitivity improvement was much more remarkable at higher humidity level. 4.2 Stability and reproducibility In order to investigate the detection precision and detection limit of the sensor, its stability and reproducibility must be tested. The sensor prepared with 100 mg/ml prepolymer was used in this test. The output frequency during a 60 s test was recorded and displayed in Fig. 9 . As noted, excellent stability at both 11%RH and 59%RH was obtained for the new sensor. Root-Mean-Square Deviation (RMSD) of the recorded frequency at 11%RH was 1.6 Hz and 5.5 Hz at 59%RH, which was much smaller than the previous SAWR sensor, whose noise level after 16-divided was above 20 Hz. The main reason was that the basic frequency was more stable when SAWR was vacuum packaged. The reproducibility test was carried out every other day. The result was shown in Fig. 10 (the original 16-divided mixed frequency was used in Y -axis). As noted, it also showed perfect reproducibility in a relatively long time. The excellent stability and reproducibility of the sensor were also closely tied to the molecular structure of the sensitive material. The silicon-containing polyelectrolyte humidity sensitive film could form a cross-linking structure between Si\u2013O groups. This structure could inhibit microstructure changes caused by solvent molecules\u2019 penetration in the polymer, which could limit the drift of the sensor effectively. In addition, Si\u2013O groups in the film could form covalent bonds with \u2013OH radical on the ceramics substrate through sol\u2013gel reaction, just as shown in Fig. 4 . These bonds would ensure a strong bonding force between the film and substrate, and enhance the anti-interference capability of the film. 4.3 Response time Desorption time was another important index for humidity sensor. There was a great limitation for traditional ceramics humidity sensors was just caused by their difficulty in dehumidifying [8,9] . In this experiment, two sensors prepared with different concentration of prepolymer (50 mg/ml and 100 mg/ml) were used and compared. Both were hung into the container with 97%RH ambient at beginning, and then changed into the container with 11%RH. The response curve of the two sensors was showed in Fig. 11 . The result indicated that the two sensors both had a relatively short desorption time, which was appropriated to the SAWR sensor. Compared with the two curves, the sensor with lower concentration had a shorter response time (nearly 10 s for 86% variation) than the one with higher concentration (nearly 90 s). The film with higher concentration could absorb more water vapors and lead to a bigger variance of conductivity. However, absorbing more water would also cause stronger bonds between film molecules and water vapors. As a result, in dehumidifying process, water vapors in the film with higher concentration were hard to release, and lead to a relatively long recovery time. 4.4 Temperature coefficient Temperature coefficient test was done to observe the temperature characteristic of the present sensor. The sensor prepared with 100 mg/ml prepolymer was used in this test. Result was showed in Fig. 12 . As temperature rose, sensitivity of the sensor also got little increase. That was because when temperature rose, dissociated ions\u2019 activity was enhanced. So a relatively larger variance of frequency was present. At the same time, microstructure of the sensitive film was also changed, which would also lead to a change of the final sensitivity. Among the relative humidity range from 11%RH to 90%RH, temperature coefficient of the novel sensor was between 0.2 and 0.4%RH/\u00b0C (10\u201340 \u00b0C). So in practical application, a temperature compensation circuit or algorithm was needed. 5 Conclusion A novel high frequency SAW humidity sensor was developed in this work. A gold IDE was added in serial with SAWR as the sensitive component. By this novel method, technical requirements for sensitive film coating could be greatly simplified, which could bring down the sensor's processing cost to a great degree. The sensitivity, stability, response-time, temperature coefficient of the novel sensor were tested and compared with the one in our previous work. It presents a remarkable improvement in both sensitivity (0.4 kHz/%RH at low humidity level; >1 kHz at high humidity level) and stability (noise level <10 Hz). This paper was mainly to propose a novel idea for high frequency SAW humidity sensor design and to confirm its feasibility. The novel topology of the serial SAW sensor could also be used in other fields such as gas detection, biochemistry detection and so on. Some aspects still need to be improved, such as the linearity and dynamic characteristic etc. An effective temperature compensation method must be found to overcome the influence of temperature. All of these problems will be solved in our further research. Acknowledgement This work is financially supported by National \u201c863\u201d program of China (contract no. 2006AA10Z215 ). References [1] M. Penzaa V.I. Anisimkin Surface acoustic wave humidity sensor using polyvinyl-alcohol film Sensors and Actuators A: Physical 76 1999 162 166 [2] Yang Li Peng Li Mujie Yang Sheng Lei Yuquan Chen Xishan Guo A surface acoustic wave humidity sensor based on electrosprayed silicon-containing polyelectrolyte Sensors and Actuators B: Chemical 145 2010 516 520 [3] A. Kawalec M. Pasternak A new high-frequency surface acoustic wave sensor for humidity measurement Instrumentation and Measurement 57 2008 2019 2023 [4] Soumayajit Sarkara Natalia Levita Gary Tepper Deposition of polymer coatings onto SAW resonators using AC electrospray Sensors and Actuators B: Chemical 114 2006 756 761 [5] Cinzia Caliendo Acoustic method of investigating the material properties and humidity sensing behavior of polymer coated piezoelectric substrates Journal of Applied Physics 100 2006 054508 [6] D.Z. Shen W.H. Zhu L.H. Nie S.Z. Yao Behaviour of a series piezoelectric sensor in electrolyte solution: part I theory Analytica Chimica Acta 276 1993 87 97 [7] Guohua Hui A novel temperature sensor based on gold interdigital electrodes and nano ZnO particles Applied Mechanics and Materials 20\u201323 2010 1495 1498 [8] R.K. Nahar V.K. Khanna Ionic doping and inversion of the characteristic of thin film porous Al 2 O 3 humidity sensor Sensors and Actuators B: Chemical 46 1998 35 41 [9] U. Dellwo P. Keller Meyer Fabrication and analysis of a thick-film humidity sensor based on MnWO 4 Sensors and Actuators A: Physics 61 1997 289 301 Sheng Lei is a PhD student in the department of Biomedical Engineering, Zhejiang University. He has been working in the Biosensor National Laboratory of China since 2006. His main research direction contains micro/nano sensors design and intelligent detection technique. Chao Deng is a postgraduate student in the department of polymer science and engineering, Zhejiang University. His research interests are polymer materials for humidity sensors. Yuquan Chen is a professor in the department of Biomedical Engineering, Zhejiang University. He was the chief leader of the Biosensor National Laboratory of China. His research interests include micro/nano biosensor design and signal process method research. Yang Li received his PhD degree in polymer chemistry and physics from Zhejiang University in 2000. He was appointed associate professor in polymer science in 2002. His research interests include polymer materials and organic/inorganic nanocomposites for chemical sensors.",
        "keywords": [
            "humidity sensor",
            "interdigital electrode",
            "polyelectrolyte",
            "series",
            "surface acoustic wave",
            "high frequency",
            "profitability"
        ],
        "authors": [
            {
                "name": "Sheng Lei",
                "org": ""
            },
            {
                "name": "Chao Deng",
                "org": "Dept of Polymer Science and Engineering, Zhejiang University, 38 Zhe Da Road, Hangzhou 310027, China"
            },
            {
                "name": "Yuquan Chen",
                "org": ""
            },
            {
                "name": "Yang Li",
                "org": "Dept of Polymer Science and Engineering, Zhejiang University, 38 Zhe Da Road, Hangzhou 310027, China"
            }
        ],
        "venue": "Sensors & Actuators: A. Physical",
        "year": 2011
    },
    "0NsTt6xu": {
        "id": "0NsTt6xu",
        "title": "Difluoroboron-Enabled Thermally Activated Delayed Fluorescence.",
        "abstract": "A new series of tetracoordinated \"boron\"-enabled thermally activated delayed fluorescence (TADF) materials with a donor-acceptor-BF2 type framework were designed and conveniently synthesized. The difluoroboron plays a critical role and acts a \"key\" to coordinate with the latent acceptor of the 2-(4-phenylpyridin-2-yl)phenol (PPyPOH) moiety to realize TADF. These materials are air stable and reveal high photoluminescence quantum yield (PLQY) of up to 99%. NOBF2-Cz and NOBF2-DPCz-doped blue OLEDs demonstrated EQEs of 11.0% with CIE coordinates of (0.14, 0.16) and 15.8% with (0.14, 0.28), respectively, and high brightness of 6761 and 19383 cd/m2 could be also achieved. Moreover, the blue OLED doped with NOBF2-DPCz and the green OLED doped with NOBF2-DMAC achieved operational lifetimes at 50% of an initial luminance (L0 = 500 cd/m2), LT50, of 54 h and 920 h, respectively. This work indicates that these tetracoordinated organoboron molecules can be acted as efficient and stable TADF materials for OLED applications.",
        "keywords": "",
        "authors": [
            {
                "name": "Guijie Li",
                "org": ""
            },
            {
                "name": "Weiwei Lou",
                "org": ""
            },
            {
                "name": "Dan Wang",
                "org": ""
            },
            {
                "name": "Chao Deng",
                "org": ""
            },
            {
                "name": "Qisheng Zhang",
                "org": ""
            }
        ],
        "venue": "ACS applied materials & interfaces",
        "year": 2019
    },
    "K1mFcLtk": {
        "id": "K1mFcLtk",
        "title": "Pyrazine-Based Blue Thermally Activated Delayed Fluorescence Materials: Combine Small Singlet-Triplet Splitting With Large Fluorescence Rate.",
        "abstract": "Metal-free thermally activated delayed fluorescence (TADF) emitters have emerged as promising candidate materials for highly efficient and low-cost organic light-emitting diodes (OLEDs). Here, a novel acceptor 2-cyanopyrazine is selected for the construction of blue TADF molecules via computer-assisted molecular design. Both theoretical prediction and experimental photophysical data indicate a small S-T energy gap (\u0394 ) and a relative large fluorescence rate ( ) in an -phenylene-bridged 2-cyanopyrazine/3,6-di--butylcarbazole compound (TCzPZCN). The   value of 3.7 \u00d7 10 s observed in a TCzPZCN doped film is among the highest in the TADF emitters with a \u0394  smaller than 0.1 eV. Blue TADF emission is observed in a TCzPZCN doped film with a short TADF lifetime of 1.9 \u03bcs. The OLEDs using TCzPZCN as emitter exhibit a maximum external quantum efficiency (EQE) of 7.6% with low-efficiency roll-off. A sky-blue device containing a derivative of TCzPZCN achieves an improved EQE maximum of 12.2% by suppressing the non-radiative decay at T.",
        "keywords": [
            "blue organic light-emitting diodes (OLED)",
            "fluorescence rate constant",
            "pyrazine",
            "singlet-triplet splitting",
            "thermally activated delayed fluorescence (TADF)"
        ],
        "authors": [
            {
                "name": "Junyuan Liu",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Keren Zhou",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Dan Wang",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Chao Deng",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Ke Duan",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Qi Ai",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            },
            {
                "name": "Qisheng Zhang",
                "org": "MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China."
            }
        ],
        "venue": "Frontiers in chemistry",
        "year": 2019
    },
    "K2R9OgwS": {
        "id": "K2R9OgwS",
        "title": "Prediction of Intramolecular Charge-Transfer Excitation for Thermally Activated Delayed Fluorescence Molecules from a Descriptor-Tuned Density Functional",
        "abstract": "The reliability of time-dependent density functional theory (TDDFT) for the calculation of the charge-transfer (CT) excitation energy depends on the proportion of the Hartree\u2013Fock (HF) exchange (\u03b1) in a hybrid functional. Here, we develop a new descriptor-tuning methodology to determine the optimal \u03b1 (OHF) in a hybrid PBE functional (PBE\u03b1). The conventional transition-density-based descriptors are shown to be inappropriate to measure the degree of CT for our approach because of the functional-dependence. A new functional-independent descriptor K, defined as the negative growth rate of the exciton binding energy upon \u03b1, is then developed and found to be highly correlated with the OHF in the PBE\u03b1. Applying the so-called K-OHF method, the lowest singlet excitation energy and singlet\u2013triplet energy splitting of various reported thermally activated delayed fluorescence (TADF) materials are successfully reproduced with mean absolute deviations of 0.07 and 0.09 eV, respectively, compared to the carefully measure...",
        "keywords": "",
        "authors": [
            {
                "name": "Chao Wang",
                "org": "MOE Key Laboratory of Macromolecular#R#Synthesis and Functionalization, Department of Polymer Science and#R#Engineering, Zhejiang University, Hangzhou 310027, China"
            },
            {
                "name": "Chao Deng",
                "org": "MOE Key Laboratory of Macromolecular#R#Synthesis and Functionalization, Department of Polymer Science and#R#Engineering, Zhejiang University, Hangzhou 310027, China"
            },
            {
                "name": "Dan Wang",
                "org": "MOE Key Laboratory of Macromolecular#R#Synthesis and Functionalization, Department of Polymer Science and#R#Engineering, Zhejiang University, Hangzhou 310027, China"
            },
            {
                "name": "Qisheng Zhang",
                "org": "MOE Key Laboratory of Macromolecular#R#Synthesis and Functionalization, Department of Polymer Science and#R#Engineering, Zhejiang University, Hangzhou 310027, China"
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2018
    },
    "wyTKlzYb": {
        "authors": [
            {
                "name": "F. Liu",
                "org": ""
            },
            {
                "name": "L.F. Peng",
                "org": ""
            },
            {
                "name": "X.M. Lai",
                "org": ""
            }
        ],
        "title": "Study on the size effect and the effect of the friction coefficient on the micro-extrusion process",
        "abstract": "With the ongoing miniaturization in products, there is a growing demand for the development of accurate forming process for mechanical micro-parts. However, in microforming process, the size effects come up and make the knowledge of the usual forming process can not be used directly. This paper investigates the size effect of H62 with the uniaxial tension experiments, and the results show both the grain size effect and the feature size effect. On the basis of the tension data, the LS-DYNA is used to analysis the micro-extrusion process. The simulation results show that the friction condition affect the microforming process seriously. When the friction condition changes, the stress state of the deformed material also changes. With the increasing of the friction coefficient, the extrusion force increases rapidly. \u00a9 2007 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            ""
        ],
        "venue": "Lecture Notes in Control and Information Sciences",
        "year": 2007,
        "id": "wyTKlzYb"
    },
    "uHEbkb7W": {
        "authors": [
            {
                "name": "F. Liu",
                "org": "School of Mechanical Engineering"
            }
        ],
        "title": "Research on the laser calibration method for the image plane center of the visual sensor",
        "abstract": "This paper explains the principle and method to calibrate the image plane center of the camera by use of laser in the pre-calibrate process of the intrinsic parameters of the visual sensor. The laser facula image has been disposed properly, so the accurate position has been located by calculating the center of mass. Consequently, the image plane center can be calibrated accurately. After the calibration, the guiding experiments show that the precision of the system is quite good which proves that camera calibrated by the method presented by this paper can satisfy the requirement of the whole system. \u00a9 2007 Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            ""
        ],
        "venue": "Lecture Notes in Control and Information Sciences",
        "year": 2007,
        "id": "uHEbkb7W"
    },
    "R6kg43wO": {
        "authors": [
            {
                "name": "Xiaohu He",
                "org": "Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University"
            },
            {
                "name": "Weijia Liao",
                "org": "Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair"
            },
            {
                "name": "Yulan Li",
                "org": "Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair"
            },
            {
                "name": "Yongqin Wang",
                "org": "Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair"
            },
            {
                "name": "Qian Chen",
                "org": "Laboratory of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Guilin Medical University"
            },
            {
                "name": "Junfei Jin",
                "org": "Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair"
            },
            {
                "name": "Songqing He",
                "org": "Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair"
            }
        ],
        "title": "Upregulation of hyaluronan-mediated motility receptor in hepatocellular carcinoma predicts poor survival",
        "abstract": "Hepatocellular carcinoma (HCC) is one of the most common types of cancer across the world. Hyaluronic acid (HA) has been reported to serve an important role in tumor extension, progression, migration and invasion. In addition, the receptor for HA-mediated motility (RHAMM) has been demonstrated to be overexpressed in different types of cancer. However, whether the upregulation of RHAMM contributes to hepatocarcinogenesis of HCC remains unclear. The present study examined the RHAMM expression in 187 HCC patients by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC). RHAMM expression was significantly upregulated in liver cancer tissues compared with that observed in adjacent normal liver tissues. The IHC analysis demonstrated that RHAMM was overexpressed in 18 (72.0%) of the 25 HCC tissues. Furthermore, overexpression of RHAMM was associated with tumor-node-metastasis (TNM), the presence of vascular invasion and recurrence. Notably, the present study indicated that the overexpression of RHAMM was closely associated with the shorter disease-free and overall survival, so it may be a potential independent predictor for disease-free and overall survival of HCC patients. In conclusion, the upregulation of RHAMM is associated with HCC progression and prognosis; and it may be a potential independent predictor of disease-free and overall survival of HCC following surgical resection.",
        "keywords": [
            "Hepatocellular carcinoma",
            "Hyaluronic acid",
            "Receptor for hyaluronic acid-mediated motility"
        ],
        "venue": "Oncology Letters",
        "year": 2015,
        "id": "R6kg43wO"
    },
    "Lk8yHQlp": {
        "authors": [
            {
                "name": "Liu Yang",
                "org": "Department of Materials Engineering"
            },
            {
                "name": "Naoe Hosoda",
                "org": "RCAST"
            },
            {
                "name": "Tadatama Suga",
                "org": "RCAST"
            }
        ],
        "title": "TEM investigation of the stainless steel/aluminum interface created by the surface activated bonding method",
        "abstract": "Stainless steel and aluminum were bonded successfully by means of the Surface Activated Bonding (SAB) method at room temperature. High-resolution electron microscopy and micro-EDS were applied to investigate the morphology of the interface thus created. In the as-bonded joints, an intermediate layer of about 10 nm thick was observed between the stainless steel and aluminum. The intermediate layer was composed of mainly silicon and certain amounts of oxygen and carbon according to the micro-EDS analysis. The intermediate layer was considered to be formed from the silicon-enriched stainless steel surface and residual impurities absorbed on the sputtered surfaces of the two components which were bonded.",
        "keywords": [
            "Aluminum",
            "Electron microscopy",
            "Interface",
            "Stainless steel",
            "Surface activated bonding"
        ],
        "venue": "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",
        "year": 1997,
        "id": "Lk8yHQlp"
    },
    "s4CUmSjp": {
        "authors": [
            {
                "name": "Liu Yang",
                "org": ""
            },
            {
                "name": "Degui Zhu",
                "org": ""
            },
            {
                "name": "Changqing Xu",
                "org": ""
            },
            {
                "name": "Jun Zhang",
                "org": ""
            },
            {
                "name": "Jian Zhang",
                "org": ""
            }
        ],
        "title": "On the role of magnesium and silicon in the formation of alumina from aluminum alloys by means of DIMOX processing",
        "abstract": "This article deals with the reaction mechanisms of the DIMOX (Directed Melt Oxided) processing of aluminum alloys. An orthogonalized experimental procedure was introduced to stipulate the effects of the reaction temperature, reaction time, and additional metallic elements, magnesium and silicon, on the oxidation process of aluminum alloys. Emphasis is placed on the distribution of magnesium and silicon in the products so that the behaviors of these two crucial elements for the formation of alumina from directed oxidation of aluminum alloys could be revealed. Alterative methods, including optical and scanning electron microscopy (SEM), electron probing, and wave spectrum analysis were applied to specify the microstructure characters of the products and locate the position of both magnesium and silicon in the reaction products. Judged by the weight gain after reaction, the results indicated that the temperature is the most influential factor in controlling the oxidation kinetics. Silicon is more effective than magnesium in accelerating the process, although magnesium is indispensable for the process to take place. While judged by the morphology of the reaction products, an excessive amount of silicon is harmful to the DIMOX process in that the final products consist of a large amount of porosity. Both magnesium and silicon are rather concentrated in specific regions than homogeneously distributed in the whole products. The contents of magnesium and silicon in the surface region are not as high as expected, with most of the magnesium being concentrated in the region directly neighboring the bulky metals and most of the Si in the residual bulky metals, although the contents of these two elements in the surface region are a little higher than the regions next to the surface. These characteristics, combined with other investigations, suggest that the decisive role of the slight amount of magnesium and silicon in the nucleation and growth of Al",
        "keywords": [
            ""
        ],
        "venue": "Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science",
        "year": 1996,
        "id": "s4CUmSjp"
    },
    "YQN46sId": {
        "authors": [
            {
                "name": "Jian Zhang",
                "org": "Southwest Jiaotong Univ"
            },
            {
                "name": "Degui Zhu",
                "org": "Southwest Jiaotong Univ"
            },
            {
                "name": "Liu Yang",
                "org": "Southwest Jiaotong Univ"
            }
        ],
        "title": "Study on self-lubricating characteristic and wear mechanism of Lanxide Al2O3/Al composites",
        "abstract": "Sliding wear behaviour of the Al",
        "keywords": [
            ""
        ],
        "venue": "Fuhe Cailiao Xuebao/Acta Materiae Compositae Sinica",
        "year": 1998,
        "id": "YQN46sId"
    },
    "SEVA6ZJI": {
        "authors": [
            {
                "name": "Jian Zhang",
                "org": ""
            },
            {
                "name": "Degui Zhu",
                "org": ""
            },
            {
                "name": "Liu Yang",
                "org": ""
            },
            {
                "name": "Shizhuo Li",
                "org": ""
            }
        ],
        "title": "Wear behavior of Lanxide Al2O3/Al composite",
        "abstract": "The sliding wear behavior of Al",
        "keywords": [
            "Lanxide Al2O3/Al composite",
            "Lubrication",
            "Wear",
            "Wear mechanism"
        ],
        "venue": "Wear",
        "year": 1998,
        "id": "SEVA6ZJI"
    },
    "ywjYDaVv": {
        "authors": [
            {
                "name": "Taek Ryong Chung",
                "org": "SUGA Lab Res. Ctr. Adv. Sci. T."
            },
            {
                "name": "Liu Yang",
                "org": "Department of Materials Engineering"
            },
            {
                "name": "Naoe Hosoda",
                "org": "RCSAT"
            },
            {
                "name": "Tadatomo Suga",
                "org": "RCSAT"
            }
        ],
        "title": "Room temperature GaAs-Si and InP-Si wafer direct bonding by the surface activated bonding method",
        "abstract": "Epitaxial growth and metalorganic chemical vapor deposition of GaAs and other III-IV compounds on silicon substrate have been investigated extensively. Such methods, however, generally result in a high density of threading dislocation because of the large lattice mismatch and a large residual thermal stress because of a large difference in thermal expansion coefficients between Si and III-IV compound semiconductors. In order to overcome those method, other conventional direct bonding techniques have been re-examined. But, high temperature annealing of these processes may cause many problems, such as doping of impurity, thermal stress introduction, defect generation and metal wiring corruption. Therefore, a new technology of wafer direct bonding has been developed. In the procedure of the bonding, which is referred to the surface activated bonding (SAB), the surfaces to be bonded are sputter-cleaned and activated by argon fast atom beam (FAB) bombardment and then brought into contact with each other in an ultrahigh vacuum. Using the SAB method, GaAs-Si and InP-Si wafer were successfully bonded at room temperature.",
        "keywords": [
            ""
        ],
        "venue": "Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms",
        "year": 1997,
        "id": "ywjYDaVv"
    },
    "XmHjy06b": {
        "authors": [
            {
                "name": "Fa-Jian Zhang",
                "org": "Fiber Optics Research Center"
            },
            {
                "name": "Liu Yang",
                "org": "Department of Materials Engineering"
            },
            {
                "name": "Xiang-Yang Huang",
                "org": "Department of Materials Engineering"
            },
            {
                "name": "De-Gui Zhu",
                "org": "Department of Materials Engineering"
            }
        ],
        "title": "The character of sintering under vacuum and its use in hot isostatic pressing in comparison with the air pre-sintering and slurry coating techniques for alumina-zirconia composites",
        "abstract": "The character of sintering under vacuum and its use in the hot isostatic pressing (HIP) of Al",
        "keywords": [
            "Air pre-sintering",
            "Hot isostatic pressing",
            "Slurry coating"
        ],
        "venue": "Journal of Materials Processing Technology",
        "year": 1998,
        "id": "XmHjy06b"
    },
    "ItZ2uYmN": {
        "authors": [
            {
                "name": "Taek Ryong Chung",
                "org": "RCAST"
            },
            {
                "name": "Liu Yang",
                "org": "Department of Materials Engineering"
            },
            {
                "name": "Naoe Hosoda",
                "org": "RCAST"
            },
            {
                "name": "Hidegi Takagi",
                "org": "Mechanical Engineering Laboratory"
            },
            {
                "name": "Tadatomo Suga",
                "org": "RCAST"
            }
        ],
        "title": "Wafer direct bonding of compound semiconductors and silicon at room temperature by the surface activated bonding method",
        "abstract": "The surface activated bonding method has been applied to bond the III-V compound semiconductor wafers and Si wafer directly at room temperature in ultra high vacuum. The procedure is as follows: the surfaces to be bonded are sputter-cleaned and activated by Ar fast atom beam irradiation and brought into contact under slight pressure. The GaAs and Si wafers bonded very well, without any macro defect being detected along the bonded interface. An amorphous intermediate layer of about 3 nm thick in most parts of the interface boundary direct bonding without any interlayer between the GaAs and Si wafers existed in a partially bonded interface by high resolution TEM.",
        "keywords": [
            "Compound semiconductor",
            "Interface",
            "SAB",
            "Silicon"
        ],
        "venue": "Applied Surface Science",
        "year": 1997,
        "id": "ItZ2uYmN"
    },
    "Bpu62J6z": {
        "id": "Bpu62J6z",
        "title": "Building Boundary Extraction Using Very High Resolution Images and LiDAR",
        "authors": [
            {
                "name": "CHENG Liang",
                "org": "Department of Geographical Information Science,Nanjing University,Nanjing ,China"
            },
            {
                "name": "GONG Jian-ya",
                "org": "State Key Lab of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan ,China"
            }
        ],
        "venue": "acta geodaetica et cartographica sinica",
        "keywords": [
            "line segment extraction",
            "very high resolution image",
            "boundary selection",
            "LiDAR"
        ],
        "year": 2008
    },
    "BdvrE7Bx": {
        "id": "BdvrE7Bx",
        "title": "Correction of atmospheric effect in ASAR interferogram using GPS and MODIS data",
        "authors": [
            {
                "name": "SONG Xiao-Gang",
                "org": " State Key Laboratory of Earthquake Dynamics,Institute of Geology,China Earthquake Administration,Beijing ,China; School of Remote Sensing and Information Engineering,Wuhan University,Wuhan ,China"
            },
            {
                "name": "LI De-Ren",
                "org": " LIESMARS,Wuhan University,Wuhan ,Chiua"
            },
            {
                "name": "SHAN Xin-Jian",
                "org": " State Key Laboratory of Earthquake Dynamics,Institute of Geology,China Earthquake Administration,Beijing ,China"
            },
            {
                "name": "LIAO Ming-Sheng",
                "org": " LIESMARS,Wuhan University,Wuhan ,Chiua"
            },
            {
                "name": "CHENG Liang",
                "org": " Department of Geographical Information Science,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "chinese journal of geophysics",
        "keywords": [
            "Atmospheric correction",
            "Zenith wet delay",
            "InSAR",
            "GPS",
            "MODIS"
        ],
        "year": 2009
    },
    "LqANE6AT": {
        "id": "LqANE6AT",
        "title": "Selection of optimal scale in remotely sensed image classification",
        "authors": [
            {
                "name": "HAN Peng",
                "org": "State Key Laboratory of Remote Sensing Science School of Geography,Beijing Normal University,Beijing ,China;Xi'an Institute of Surveying and Mapping,Shaanxi Xi'an ,China;State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Hubei Wuhan ,China"
            },
            {
                "name": "GONG Jianya",
                "org": "State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Hubei Wuhan ,China"
            },
            {
                "name": "LI Zhilin",
                "org": "State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Hubei Wuhan ,China"
            },
            {
                "name": "BO Yanchen",
                "org": "State Key Laboratory of Remote Sensing Science School of Geography,Beijing Normal University,Beijing ,China"
            },
            {
                "name": "CHENG Liang",
                "org": "Department of Geographical Information Science,Nanjing University,Jiangsu Nanjing ,China"
            }
        ],
        "venue": "journal of remote sensing",
        "keywords": [
            "multi-spectral information",
            "information entropy",
            "resolution",
            "optimal scale",
            "image classification"
        ],
        "year": 2010
    },
    "ShQoB8YZ": {
        "id": "ShQoB8YZ",
        "title": "An improved adaptive watermarking algorithm for vector digital maps",
        "authors": [
            {
                "name": "Han Peng",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Gong Jianya",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            },
            {
                "name": "Cheng Liang",
                "org": "Wuhan University(Wuhan University),Wuhan,China"
            }
        ],
        "venue": "international geoscience and remote sensing symposium (igarss)",
        "keywords": [
            "digital watermark",
            "mean-value detection",
            "the original watermarked map",
            "vector digital map",
            "production",
            "robustness",
            "navigation",
            "intensity modulation",
            "digital mapping",
            "remote sensing",
            "geographic information systems",
            "watermarking"
        ],
        "year": 2006
    },
    "2hkwetXM": {
        "id": "2hkwetXM",
        "title": "Comparing the Effect of Aggregation Methods for Remote Sensing Image",
        "authors": [
            {
                "name": "HAN Peng",
                "org": "Wuhan University,State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Hubei Wuhan  China"
            },
            {
                "name": "GONG Jian-ya",
                "org": "Wuhan University,State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Hubei Wuhan  China"
            },
            {
                "name": "LI Zhi-lin",
                "org": "Wuhan University,State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Hubei Wuhan  China"
            },
            {
                "name": "CHENG Liang",
                "org": "Department of Geographical Information ScIence,Nanjing University,Jiangsu Nanjing ,China"
            }
        ],
        "venue": "journal of remote sensing",
        "keywords": [
            "aggregation method",
            "linear diffuse function",
            "quality assessment",
            "structural similarity",
            "resolution"
        ],
        "year": 2008
    },
    "3lbWI4oY": {
        "id": "3lbWI4oY",
        "title": "A review on realistic building 3D reconstruction using LiDAR and imagery",
        "authors": [
            {
                "name": "CHENG Liang",
                "org": " Department of Geographical Information Science,Nanjing University,Nanjing ,China"
            },
            {
                "name": "GONG Jian-ya",
                "org": " State Key Laboratory of Information Engineering in Surveying,Mapping and Remote Sensing,Wuhan University,Wuhan ,China"
            },
            {
                "name": "HAN Wen-quan",
                "org": " Nanjing institute of surveying,mapping & geotechnical investigation,co. Ltd,Nanjing ,China"
            }
        ],
        "venue": "science of surveying and mapping",
        "keywords": [
            "realistic",
            "imagery",
            "LiDAR",
            "building 3D reconstruction"
        ],
        "year": 2009
    },
    "hzOhoMqj": {
        "id": "hzOhoMqj",
        "title": "Analysis of farmland fragmentation in China Modernization Demonstration Zone since \"Reform and Openness\": a case study of South Jiangsu Province.",
        "authors": [
            {
                "name": "liang cheng"
            },
            {
                "name": "ni xia"
            },
            {
                "name": "ping jiang"
            },
            {
                "name": "l zhong"
            },
            {
                "name": "y pian"
            },
            {
                "name": "yu duan"
            },
            {
                "name": "qiuhao huang"
            },
            {
                "name": "ming li"
            }
        ],
        "venue": "scientific reports",
        "keywords": [],
        "year": 2015
    },
    "ohGzLhVv": {
        "id": "ohGzLhVv",
        "title": "Farmland protection policies and rapid urbanization in China: A case study for Changzhou City",
        "authors": [
            {
                "name": "cheng liang"
            },
            {
                "name": "jiang penghui"
            },
            {
                "name": "chen wei"
            },
            {
                "name": "li manchun"
            },
            {
                "name": "wang liyan"
            },
            {
                "name": "gong yuan"
            },
            {
                "name": "pian yuzhe"
            },
            {
                "name": "xia nan"
            },
            {
                "name": "duan yuewei"
            },
            {
                "name": "huang qiuhao"
            }
        ],
        "venue": "land use policy",
        "keywords": [
            "rda",
            "china"
        ],
        "year": 2015
    },
    "MpcNa84J": {
        "id": "MpcNa84J",
        "title": "Using LiDAR for digital documentation of ancient city walls",
        "authors": [
            {
                "name": "liang cheng"
            },
            {
                "name": "yajun wang"
            },
            {
                "name": "yanming chen"
            },
            {
                "name": "manchun li"
            }
        ],
        "venue": "journal of cultural heritage",
        "keywords": [],
        "year": 2015
    },
    "0JZSpoqF": {
        "id": "0JZSpoqF",
        "title": "Automatic Optimization for Affine Invariant Feature Matching on Remote Sensing Imagery",
        "authors": [
            {
                "name": "CHENG Liang",
                "org": " Department of Geographic Information Science,Nanjing University,22 Hankou Road,Nanjing ,China"
            },
            {
                "name": "GONG Jianya",
                "org": " State Key Laboratory for Information Engineering in Surveying,Mapping and Remote Sensing, Wuhan University,Wuhan ,China"
            },
            {
                "name": "HAN Peng",
                "org": " Xi'an Institute of Surveying and Mapping,1 Middle Yanta Road,Xi'an ,China"
            },
            {
                "name": "SONG Xiaogang",
                "org": " State Key Laboratory of Earthquake Dynamics,Institute of Geology,China Earthquake Administration, Qijiahuozi,Beijing ,China"
            }
        ],
        "venue": "geomatics and information science of wuhan university",
        "keywords": [
            "affine invariant feature",
            "feature matching",
            "RANSAC",
            "correct matching rate",
            "automated optimization"
        ],
        "year": 2009
    },
    "SyIHw8rc": {
        "id": "SyIHw8rc",
        "title": "Correction of atmospheric effect in repeat-pass InSAR measurements based on GPS and atmospheric transport model",
        "authors": [
            {
                "name": "SONG Xiao-Gang",
                "org": " School of Remote Sensing and Information Engineering,Wuhan University,Wuhan ,China"
            },
            {
                "name": "LI De-Ren",
                "org": " LIESMARS,Wuhan University,Wuhan ,China"
            },
            {
                "name": "SHAN Xin-Jian"
            },
            {
                "name": "LIAO Ming-Sheng",
                "org": " LIESMARS,Wuhan University,Wuhan ,China"
            },
            {
                "name": "CHENG Liang",
                "org": " Department of Geographical Information Science,Nanjing University,Nanjing ,China"
            }
        ],
        "venue": "chinese journal of geophysics",
        "keywords": [
            "Atmospheric correction",
            "Atmospheric transport model",
            "InSAR",
            "GPS"
        ],
        "year": 2009
    },
    "Zbc5rCXE": {
        "id": "Zbc5rCXE",
        "title": "Technical Framework of Feature Extraction Based on Pixel-Level SAR Image Time Series",
        "authors": [
            {
                "name": "liang cheng",
                "org": "nanjing university"
            },
            {
                "name": "yafei wang",
                "org": "chinese academy of sciences"
            },
            {
                "name": "lishan zhong",
                "org": "nanjing university"
            },
            {
                "name": "peijun du",
                "org": "nanjing university"
            },
            {
                "name": "manchun li",
                "org": "nanjing university"
            }
        ],
        "venue": "selected topics in applied earth observations and remote sensing, ieee journal of",
        "keywords": [
            "feature extraction",
            "geophysical image processing",
            "radar imaging",
            "remote sensing by radar",
            "synthetic aperture radar",
            "envisat asar images",
            "sar image data",
            "dynamic time warping",
            "feature extraction technical framework",
            "multitemporal images",
            "pixel-level sar image time series",
            "progressive binary partition",
            "dtw",
            "sar image time series",
            "image registration",
            "pixel-level",
            "similarity measurement",
            "spatiotemporal analysis",
            "time measurement",
            "time series analysis",
            "remote sensing",
            "earth"
        ],
        "year": 2015
    },
    "vfNp4Dcf": {
        "authors": [
            {
                "name": "Zhengzheng Chen",
                "org": "State Key Laboratory of Materials Processing and Die and Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Xiao Liu",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Kyeongjae Cho",
                "org": "Department of Materials Science and Engineering, University of Texas at Dallas"
            },
            {
                "name": "Rong Chen",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Bin Shan",
                "org": "Department of Materials Science and Engineering, University of Texas at Dallas"
            }
        ],
        "title": "Density Functional Theory Study of the Oxygen Chemistry and NO Oxidation Mechanism on Low-Index Surfaces of SmMn<inf>2</inf>O<inf>5</inf> Mullite",
        "abstract": "SmMn<inf>2</inf>O<inf>5</inf> mullite has recently been reported to be a promising alternative to traditional Pt-based catalysts for environmental and energy applications. By performing density functional theory calculations, we have systematically investigated lattice oxygen reactivity and oxygen adsorption/dissociation/migration behaviors on low-index surfaces of SmMn<inf>2</inf>O<inf>5</inf> mullite with different terminations. On the basis of the oxygen chemistry and thermodynamic stability of different facets, we conclude that (100)<sup>3+</sup>, (010)<sup>4+</sup>, and (001)<sup>4+</sup> are reactive toward NO oxidation via either the Mars van Krevelen (MvK) or Eley-Rideal (ER) mechanism. Concrete NO \u2192 NO<inf>2</inf> reaction paths on these candidate mechanisms have also been calculated. Both the (010)<sup>4+</sup> and (001)<sup>4+</sup> surfaces presented desirable activities. Bridge MnO sites on (010)<sup>4+</sup> surface are identified to be the most active for NO oxidation through the ER mechanism with the lowest barrier of \u223c0.38 eV. We have also identified that on all active sites considered in the current study, the rate-determining step in NO \u2192 NO<inf>2</inf> oxidation reaction is the NO<inf>2</inf> desorption. Our study gives an insight into the mechanisms of NO oxidation on SmMn<inf>2</inf>O<inf>5</inf> mullite at the atomic level and can be used to guide further improvement of its catalytic performance.",
        "keywords": [
            "density functional theory calculations",
            "NO oxidation",
            "oxygen chemistry",
            "SmMn<inf>2</inf>O<inf>5</inf> mullite"
        ],
        "venue": "ACS Catalysis",
        "year": 2015,
        "id": "vfNp4Dcf"
    },
    "7QUmg0ZY": {
        "authors": [
            {
                "name": "Chen-Long Duan",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Xiao Liu",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Bin Shan",
                "org": "State Key Laboratory of Material Processing and Die and Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Rong Chen",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            }
        ],
        "title": "Fluidized bed coupled rotary reactor for nanoparticles coating via atomic layer deposition",
        "abstract": "A fluidized bed coupled rotary reactor has been designed for coating on nanoparticles (NPs) via atomic layer deposition. It consists of five major parts: reaction chamber, dosing and fluidizing section, pumping section, rotary manipulator components, as well as a double-layer cartridge for the storage of particles. In the deposition procedure, continuous fluidization of particles enlarges and homogenizes the void fraction in the particle bed, while rotation enhances the gas-solid interactions to stabilize fluidization. The particle cartridge presented here enables both the fluidization and rotation acting on the particle bed, demonstrated by the analysis of pressure drop. Moreover, enlarged interstitials and intense gas-solid contact under sufficient fluidizing velocity and proper rotation speed facilitate the precursor delivery throughout the particle bed and consequently provide a fast coating process. The cartridge can ensure precursors flowing through the particle bed exclusively to achieve high utilization without static exposure operation. By optimizing superficial gas velocities and rotation speeds, minimum pulse time for complete coating has been shortened in experiment, and in situ mass spectrometry showed the precursor usage can reach 90%. Inductively coupled plasma-optical emission spectroscopy results suggested a saturated growth of nanoscale Al<inf>2</inf>O<inf>3</inf> films on spherical SiO<inf>2</inf> NPs. Finally, the uniformity and composition of the shells were characterized by high angle annular dark field-transmission electron microscopy and energy dispersive X-ray spectroscopy.",
        "keywords": [
            ""
        ],
        "venue": "Review of Scientific Instruments",
        "year": 2015,
        "id": "7QUmg0ZY"
    },
    "ZrhRLDJ3": {
        "authors": [
            {
                "name": "Xiao Liu",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology and School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Yanwei Wen",
                "org": "State Key Laboratory of Material Processing and Die and Mould Technology and School of Materials Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Bin Shan",
                "org": "Department of Materials Science and Engineering, The University of Texas at Dallas"
            },
            {
                "name": "Kyeongjae Cho",
                "org": "Department of Materials Science and Engineering, The University of Texas at Dallas"
            },
            {
                "name": "Z. Chen",
                "org": "State Key Laboratory of Material Processing and Die and Mould Technology and School of Materials Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Rong Chen",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology and School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            }
        ],
        "title": "Combined effects of defects and hydroxyl groups on the electronic transport properties of reduced graphene oxide",
        "abstract": "The effects of four typical defects on the hydroxyl groups\u2019 migration and the conductivity of graphene have been studied using density functional theory and nonequilibrium Green\u2019s function formalism. An obvious anisotropy of the diffusion barriers along different paths is correlated to the symmetric behavior of spin-polarized charge density around the defects. The migration energy scenario indicates that the defects effectively hinder the hydroxyl groups\u2019 migration toward them, indicating that most hydroxyl groups could be stabilized outside the defect region in reduced graphene oxide. Through the electronic transport calculations and local density of states analysis, hydroxyl groups locating outside of the defect region will cause the transport channels near the Fermi level to disappear and reduce the conductance considerably.",
        "keywords": [
            ""
        ],
        "venue": "Applied Physics A: Materials Science and Processing",
        "year": 2014,
        "id": "ZrhRLDJ3"
    },
    "Aw0ypTHC": {
        "authors": [
            {
                "name": "Xiao Liu",
                "org": ""
            },
            {
                "name": "Zhengzheng Chen",
                "org": ""
            },
            {
                "name": "Yanwei Wen",
                "org": ""
            },
            {
                "name": "Rong Chen",
                "org": ""
            },
            {
                "name": "Bin Shan",
                "org": ""
            }
        ],
        "title": "Surface stabilities and NO oxidation kinetics on hexagonal-phase LaCoO",
        "abstract": "LaCoO",
        "keywords": [
            ""
        ],
        "venue": "Catalysis Science and Technology",
        "year": 2014,
        "id": "Aw0ypTHC"
    },
    "vwvQXmgd": {
        "authors": [
            {
                "name": "Yanwei Wen",
                "org": "State Key Laboratory of Materials Processing and Die and Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Xiao Liu",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Xianbao Duan",
                "org": "State Key Laboratory of Materials Processing and Die and Mold Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Kyeongjae Cho",
                "org": "Department of Materials Science and Engineering, University of Texas at Dallas"
            },
            {
                "name": "Rong Chen",
                "org": "State Key Laboratory of Digital Manufacturing Equipment and Technology, School of Mechanical Science and Engineering, Huazhong University of Science and Technology"
            },
            {
                "name": "Bin Shan",
                "org": "Department of Materials Science and Engineering, University of Texas at Dallas"
            }
        ],
        "title": "Theoretical study of Li-doped sp<sup>2</sup>-sp<sup>3</sup> hybrid carbon network for hydrogen storage",
        "abstract": "Nanoporous carbon structures are promising candidates for hydrogen physisorption storage due to their high specific area and light weight. Using first-principles calculations, we predict a type of sp<sup>2</sup>-sp<sup>3</sup> hybrid carbon network (HCN) with well-aligned and size-tunable nanopores that are suitable for hydrogen storage. The unique shape of the nanopores is beneficial for the selective Li atoms doping and induces an enhanced H<inf>2</inf> binding energy that can be attributed to the improved interaction between polarized H<inf>2</inf> and Li ion. A maximum weight percentage of hydrogen storage reaches 6.28 wt % with an average binding energy of -0.19 eV in Li-doped HCN. Together with the ultrahigh volumetric density of hydrogen (102 g/L), the HCN structure is a promising candidate for the hydrogen storage medium.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2015,
        "id": "vwvQXmgd"
    },
    "H5V2k7wQ": {
        "authors": [
            {
                "name": "Xiao Liu",
                "org": ""
            },
            {
                "name": "Yanwei Wen",
                "org": ""
            },
            {
                "name": "Zhengzheng Chen",
                "org": ""
            },
            {
                "name": "Bin Shan",
                "org": ""
            },
            {
                "name": "Rong Chen",
                "org": ""
            }
        ],
        "title": "A first-principles study of sodium adsorption and diffusion on phosphorene",
        "abstract": "The structural, electronic, electrochemical as well as diffusion properties of Na doped phosphorene have been investigated based on first-principles calculations. The strong binding energy between Na and phosphorene indicates that Na could be stabilized on the surface of phosphorene without clustering. By comparing the adsorption of Na atoms on one side and on both sides of phosphorene, it has been found that Na-Na exhibits strong repulsion at the Na-Na distance of less than 4.35 \u00c5. The Na intercalation capacity is estimated to be 324 mA h g<sup>-1</sup> and the calculated discharge curve indicates quite a low Na<sup>+</sup>/Na voltage of phosphorene. Moreover, the diffusion energy barrier of Na atoms on the phosphorene surface at both low and high Na concentrations is as low as 40-63 meV, which implies the high mobility of Na during the charge/discharge process.",
        "keywords": [
            ""
        ],
        "venue": "Physical Chemistry Chemical Physics",
        "year": 2015,
        "id": "H5V2k7wQ"
    },
    "EVl3twUh": {
        "authors": [
            {
                "name": "Fang-Fang Xu",
                "org": "JST, CREST"
            },
            {
                "name": "Tomohiro Morohoshi",
                "org": "JST, CREST"
            },
            {
                "name": "Wen-Zhao Wang",
                "org": "Laboratory for Food Safety and Environmental Technology, Institutes of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences"
            },
            {
                "name": "Yuka Yamaguchi",
                "org": "Department of Material and Environmental Chemistry, Graduate School of Engineering, Utsunomiya University"
            },
            {
                "name": "Yan Liang",
                "org": "Laboratory for Food Safety and Environmental Technology, Institutes of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences"
            },
            {
                "name": "Tsukasa Ikeda",
                "org": "JST, CREST"
            }
        ],
        "title": "Evaluation of intraspecies interactions in biofilm formation by methylobacterium species isolated from pink-pigmented household biofilms",
        "abstract": "Concern regarding household biofilms has grown due to their widespread existence and potential to threaten human health by serving as pathogen reservoirs. Previous studies identified Methylobacterium as one of the dominant genera found in household biofilms. In the present study, we examined the mechanisms underlying biofilm formation by using the bacterial consortium found in household pink slime. A clone library analysis revealed that Methylobacterium was the predominant genus in household pink slime. In addition, 16 out of 21 pink-pigmented bacterial isolates were assigned to the genus Methylobacterium. Although all of the Methylobacterium isolates formed low-level biofilms, the amount of the biofilms formed by Methylobacterium sp. P-1M and P-18S was significantly increased by co-culturing with other Methylobacterium strains that belonged to a specific phylogenetic group. The single-species biofilm was easily washed from the glass surface, whereas the dual-species biofilm strongly adhered after washing. A confocal laser scanning microscopy analysis showed that the dual-species biofilms were significantly thicker and tighter than the single-species biofilms.",
        "keywords": [
            "Household biofilm",
            "Intraspecies interaction",
            "Methylobacterium",
            "Pink biofilm"
        ],
        "venue": "Microbes and Environments",
        "year": 2014,
        "id": "EVl3twUh"
    },
    "Up1t6W70": {
        "authors": [
            {
                "name": "H. Huo",
                "org": "Northwest Inst. of Nuclear Technol."
            },
            {
                "name": "X. Huang",
                "org": "Northwest Inst. of Nuclear Technol."
            },
            {
                "name": "J. Lin",
                "org": "Northwest Inst. of Nuclear Technol."
            }
        ],
        "title": "Method for calculating the range of bolt pre-stress of assembled confinement vessels due to the action of the inner impact",
        "abstract": "Sealing of a confinement vessel, assembled by joins bolts and flanges under the inner impact loading, is an important problem. In this paper, supposing that every part of the vessel is rigid body and bolts are spring, and displacement difference between adjoined objects is the elongation of the corresponding bolt. Considering compress of the flange, the relationship between bolt's pre-stress and vibration's response is investigated under the loading of inner centered-explosion when the confinement vessel is modeled as a three-freedom spring-mass system. The range of pre-stress is identified by yield stress of bolt' and minimal stress of off-lift of flange interface. A new method for calculating the range of pre-stress satisfying the confinement requirement is obtained. Theoretical analysis and experiment results are indicated that it can be applied to real world problems and be generalized into multi-freedom assembled vessels.",
        "keywords": [
            "Bolts",
            "Calculating method",
            "Confinement",
            "Explosion vessels",
            "Pre-stress"
        ],
        "venue": "Jixie Qiangdu/Journal of Mechanical Strength",
        "year": 2001,
        "id": "Up1t6W70"
    },
    "oYjHNJFO": {
        "authors": [
            {
                "name": "Tianci Yang",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Xiaomin Xu",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Juan Hou",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Zhenyu Gong",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Zhiping Cheng",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Weizhong Fan",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Tao Fu",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Susheng Wang",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Xiaojun Ye",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Yinping Wu",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Ming Chen",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Feng Ling",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Xiayan Feng",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Guiren Zhu",
                "org": "Yiwu Centre for Disease Control and Prevention"
            },
            {
                "name": "Zhangyao Ren",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Guiming Fu",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            },
            {
                "name": "Fang He",
                "org": "Zhejiang Provincial Centre for Disease Control and Prevention"
            }
        ],
        "title": "Dengue fever vector composition and pesticide residues in Yiwu, Zhejiang Province, China",
        "abstract": "In 2009, an outbreak of dengue fever occurred in Yiwu, the major international market in Zhejiang province, China. A mosquito vector eradication program was undertaken using several insecticides to limit further transmission of the dengue virus. At the conclusion of this effort, the affected area was surveyed for dengue fever vector species, and mosquito-breeding area water samples were collected and analyzed for residual pesticide content. The survey detected the Asian tiger mosquito, Aedes albopictus (Skuse), in 19 villages in Yiwu, accounting for 51.7% of the mosquitoes in the 89 samples collected. Other species collected included Armigeres subalbatus (Coquillett), Culex pipiens quinquefasciatus Say, Cx. tritaeniorhynchus Giles, Cx. mimulus Edwards, and Anopheles sinensis Wiedemann. Analysis of water from 45 mosquito-breeding sites using gas chromatography-mass spectrometry detected a total of 7 pesticides, including the herbicide prometryn, 2 organophosphate insecticides (chlorpyrifos and triazophos), and 3 pyrethroid insecticides (cyhalothrin, Cypermethrin, and permethrin). The maximum level of permethrin detected was 323.9 \u03bcg/L in breeding waters in which Ae. albopictus and Ar. subalbatus coexisted.",
        "keywords": [
            "Dengue",
            "Mosquito",
            "Pesticide residue",
            "Vectors",
            "Water analysis"
        ],
        "venue": "Journal of Entomological Science",
        "year": 2012,
        "id": "oYjHNJFO"
    },
    "KE9xNVmg": {
        "id": "KE9xNVmg",
        "title": "Cardioprotective effects of Aconiti Lateralis Radix Praeparata combined with Zingiberis Rhizoma on doxorubicin-induced chronic heart failure in rats and potential mechanisms.",
        "abstract": "Network pharmacology analysis would be an effective network analyze workflow which was feasible for evaluating the pharmacological effect of a multi-drug complex system. The Chinese herbal couple ALRP-ZR had a better therapeutic effect than their single-use against DOX-induced CHF, which is related to enhancing left ventricular function by activating the PPAR\u03b1/PGC-1\u03b1/sirt3 pathway.",
        "keywords": [
            "Aconiti latetralis radix praeparata (ALRP)",
            "Chronic heart failure",
            "Doxorubicin",
            "Energy metabolism",
            "Zingiberis rhizoma (ZR)"
        ],
        "authors": [
            {
                "name": "Jianxia Wen",
                "org": "Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Wenjun Zou",
                "org": "Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China."
            },
            {
                "name": "Ruilin Wang",
                "org": "Department of Traditional Chinese Medicine, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Honghong Liu",
                "org": "Integrative Medical Center, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Yuxue Yang",
                "org": "Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Haotian Li",
                "org": "Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Shizhang Wei",
                "org": "Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Ruisheng Li",
                "org": "Research Center for Clinical and Translational Medicine, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, 100039, China."
            },
            {
                "name": "Huadan Cai",
                "org": "Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China."
            },
            {
                "name": "Jian Wang",
                "org": "Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address: jianwang08@163.com."
            },
            {
                "name": "Yanling Zhao",
                "org": "Department of Pharmacy, Fifth Medical Center, 302 Military Hospital of China, Beijing, 100039, China. Electronic address: zhaoyl2855@126.com."
            }
        ],
        "venue": "Journal of ethnopharmacology",
        "year": 2019
    },
    "A72O8oAw": {
        "id": "A72O8oAw",
        "title": "Effects of Magnolia officinalis compatibility with Polygala tenuifolia on mitochondrial metabolism in rats\u2019 liver based on bio-thermodynamics",
        "abstract": "Polygala tenuifolia (Yuanzhi in Chinese) has gastrointestinal toxicity which can be significantly alleviated by Magnolia officinalis (Houpo in Chinese) due to the heat production of mitochondria based on our previous study. In this paper, we have compared the different effects of M. officinalis, P. tenuifolia and their compatibility group on the mitochondrial metabolism in rats liver based on bio-thermodynamics. According to the growth thermogenic curves, we could obtain the exponential growth parameters to reflect the effect of reduced toxicity affected by M. officinalis. We also compared the further functional characteristics of M. officinalis, P. tenuifolia and their compatibility by means of statistical methods. The different experiment concentrations on mitochondrial metabolism were analyzed by principle component analysis (PCA). By analyzing the effect of different experiment concentrations on mitochondrial growth rate, we found that the metabolism rate K of mitochondria in P. tenuifolia group reduced in doses dependently. We obtained the exponential growth constant K and depicted the metabolism thermal power-time curve information of mitochondria at the same time. Our results showed that with the increased concentration of P. tenuifolia extracts, there was significant promotion of heat production by mitochondria while inhibition of M. officinalis extracts and their compatibility extracts. Analyzed by PCA, M. officinalis group distributed more scattered and had far influence on mitochondrial metabolism when compared to M. officinalis group and their compatibility group. It showed that P. tenuifolia\u2019s gastrointestinal side effect was related to the change of mitochondrial energy metabolism.",
        "keywords": "",
        "authors": [
            {
                "name": "Juan Du",
                "org": "Chengdu University of Traditional Chinese Medicine"
            },
            {
                "name": "Jianxia Wen",
                "org": "Chengdu University of Traditional Chinese Medicine"
            },
            {
                "name": "Mingquan Wu",
                "org": "Chengdu University of Traditional Chinese Medicine"
            },
            {
                "name": "Yanling Zhao",
                "org": "302 Hospital of People\u2019s Liberation Army"
            },
            {
                "name": "Lihua Huang",
                "org": "Chengdu University of Traditional Chinese Medicine"
            },
            {
                "name": "Yang Wang",
                "org": "Chengdu Shuangliu District Maternal and Child Health Hospital"
            },
            {
                "name": "Qian Xie",
                "org": "Chengdu University of Traditional Chinese Medicine"
            },
            {
                "name": "Xiao Ma",
                "org": "Chengdu University of Traditional Chinese Medicine"
            },
            {
                "name": "Jian Wang",
                "org": "Chengdu University of Traditional Chinese Medicine"
            }
        ],
        "venue": "Journal of Thermal Analysis and Calorimetry",
        "year": 2017
    },
    "66c9YZXs": {
        "id": "66c9YZXs",
        "title": "Corrigendum to \u201cProtective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms\u201d [Biomed. Pharmacother. 115 (2019) 108881]",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jianxia Wen",
                "org": ""
            },
            {
                "name": "Jian Wang",
                "org": ""
            },
            {
                "name": "Pengyan Li",
                "org": ""
            },
            {
                "name": "Ruilin Wang",
                "org": ""
            },
            {
                "name": "Jiabo Wang",
                "org": ""
            },
            {
                "name": "Xuelin Zhou",
                "org": ""
            },
            {
                "name": "Lu Zhang",
                "org": ""
            },
            {
                "name": "Haotian Li",
                "org": ""
            },
            {
                "name": "Shizhang Wei",
                "org": ""
            },
            {
                "name": "Huadan Cai",
                "org": ""
            },
            {
                "name": "Yanling Zhao",
                "org": ""
            }
        ],
        "venue": "Biomedicine & Pharmacotherapy",
        "year": 2019
    },
    "TqU74Qxx": {
        "id": "TqU74Qxx",
        "title": "Therapeutic Efficacy and Safety of Paeoniae Radix Rubra Formulae in Relieving Hyperbilirubinemia Induced by Viral Hepatitis: A Meta-Analysis",
        "abstract": "Objective: Hyperbilirubinemia is one of the most devastating pathologies induced by various liver diseases. Formulae related to Paeoniae Radix Rubra (PRR) at high doses have been applied to treat hyperbilirubinemia in traditional Chinese medicine. The aim of this systematic review and meta-analysis is to assess the efficacy and safety of formulae relevant to high-dose PRR in patients suffering from hyperbilirubinemia induced by viral hepatitis. Methods: We performed a meta-analysis of randomized-controlled clinical trials to evaluate the efficacy and safety of formulae that apply a high dose of PRR for hyperbilirubinemia. Seven databases were searched until April 2015. All studies were included according to detailed criteria and assessed for methodological quality. The outcome measurements were recorded for further analysis using the Revman 5.2.11 software. Results: Fifteen articles involving 1323 patients with hyperbilirubinemia were included. Formulae with high-dose PRR might promote the efficacy of either a combined application ([OR: 3.98, 95%CI (2.91, 5.43)]; Pu003c0.01) or a single application ([OR: 4.00, 95%CI (1.50, 10.68)]; Pu003c0.01) for hyperbilirubinemia. The indices of TBIL, ALT and AST significantly decreased ([MD: -75.57, 95%CI (-94.88, -56.26)], [MD: -26.54, 95%CI (-36.19, -16.88)] and ([MD: -28.94, 95%CI (-46.26, -11.61)]; Pu003c0.01), respectively. In addition, formulae with high-dose PRR could enhance the treatment efficacy of hyperbilirubinemia triggered by hepatitis B ([OR: 2.98, 95% CI (1.75, 5.05)]; Pu003c0.01). Furthermore, the efficacy was enhanced with an increasing dosage of PRR. Two articles reported that no side effects occurred in clinical trials, and 3 studies noted that patients presented light digestive tract symptoms. Conclusion: Formulae relevant to high-dose PRR ameliorate hyperbilirubinemia and might constitute a promising therapeutic approach. For widespread acceptance by practitioners, more rigorously designed multicenter, double-blind, randomized and large-scale controlled trials are required.",
        "keywords": "",
        "authors": [
            {
                "name": "Yin-Qiu Huang",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Xiao Ma",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Jian Wang",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Yanling Zhao",
                "org": "Department of Pharmacy, 302 Military Hospital of China, Beijing, China"
            },
            {
                "name": "Jiabo Wang",
                "org": "China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing, China"
            },
            {
                "name": "Zhe Chen",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Yun Zhu",
                "org": "Department of Integrative Medical Center, 302 Hospital of People's Liberation Army, Beijing, China"
            },
            {
                "name": "Limei Shan",
                "org": "Department of Integrative Medical Center, 302 Hospital of People's Liberation Army, Beijing, China"
            },
            {
                "name": "Shizhang Wei",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Ji Wang",
                "org": "Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China"
            },
            {
                "name": "Xiao-He Xiao",
                "org": "China Military Institute of Chinese Medicine, 302 Hospital of People's Liberation Army, Beijing, China"
            }
        ],
        "venue": "Frontiers in Pharmacology",
        "year": 2016
    },
    "kxbkg6uZ": {
        "id": "kxbkg6uZ",
        "title": "Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms.",
        "abstract": "Higenamine (HG) is a well-known selective activator of beta2-adrenergic receptor (\u03b22-AR) with a positive inotropic effect. The present study showed that HG combined with [6]-gingerol (HG/[6]-GR) protects H9c2 cells from doxorubicin (DOX)-induced mitochondrial energy metabolism disorder and respiratory dysfunction. H9c2 cells were pretreated with HG/[6]-GR for 2\u2009h before DOX treatment in all procedures. Cell viability was quantified by a cell counting kit\u20118 assay. Cardiomyocyte morphology, proliferation, and mitochondrial function were detected by a high content screening (HCS) assay. Cell mitochondrial stress was measured by a Seahorse XFp analyzer. To further investigate the protective mechanism of HG/[6]-GR, mRNA and protein expression levels of PPAR\u03b1/PGC-1\u03b1/Sirt3 pathway-related molecules were detected. The present data demonstrated that protective effects of HG/[6]-GR combination were presented in mitochondria, which increased cell viability, ameliorated DOX-induced mitochondrial dysfunction, increased mitochondrial oxygen consumption rate (OCR) and extracellular acidification rate (ECAR). Most importantly, the protective effects were abrogated by GW6471 (a PPAR\u03b1 inhibitor) and ameliorated by Wy14643 (a PPAR\u03b1 agonist). Moreover, the combined use of HG and [6]-GR exerted more profound protective effects than either drug as a single agent. In conclusion, the results suggested that HG/[6]-GR ameliorates DOX-induced mitochondrial energy metabolism disorder and respiratory function impairment in H9c2 cells, and it indicated that the protective mechanism may be related to upregulation of the PPAR\u03b1/PGC-1\u03b1/Sirt3 pathway, which promotes mitochondrial energy metabolism and protects against heart failure.",
        "keywords": [
            "Doxorubicin",
            "Energy metabolism",
            "H9c2 cells",
            "Heart failure",
            "Higenamine",
            "[6]-Gingerol"
        ],
        "authors": [
            {
                "name": "Jianxia Wen",
                "org": "College of Pharmacy, Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Jian Wang",
                "org": "College of Pharmacy, Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China. Electronic address: jianwang08@163.com."
            },
            {
                "name": "Pengyan Li",
                "org": "China Military Institute of Chinese Medicine, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Ruilin Wang",
                "org": "Integrative Medical Center, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Jiabo Wang",
                "org": "China Military Institute of Chinese Medicine, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Xuelin Zhou",
                "org": "Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China."
            },
            {
                "name": "Lu Zhang",
                "org": "College of Pharmacy, Zhejiang University of Chinese Medicine, Hangzhou, China."
            },
            {
                "name": "Haotian Li",
                "org": "Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Shizhang Wei",
                "org": "Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Huadan Cai",
                "org": "Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, China."
            },
            {
                "name": "Yanling Zhao",
                "org": "Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing, China. Electronic address: zhaoyl2855@126.com."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
        "year": 2019
    },
    "PqAjUKKA": {
        "id": "PqAjUKKA",
        "title": "Shexiang Baoxin Pills as an Adjuvant Treatment for Chronic Heart Failure: A System Review and Meta-Analysis",
        "abstract": "Background. Shexiang Baoxin pills (SXBXP), as a Traditional Chinese Medicine, are widely used for chronic heart failure in China. It is essential to systematically assess the efficacy and safety of SXBXP as an adjuvant treatment for chronic heart failure. Methods. Seven English and Chinese electronic databases (PubMed, Embase, Cochrane Library, CBM, Wanfang, VMIS, and CNKI) were searched from inception to July 2017. The Cochrane Risk of Bias tool was used to evaluate the methodological quality of eligible studies. Meta-analysis was performed by Review Manager 5.3. Results. A total of 27 RCTs with 2637 participants were included in this review. Compared to conventional treatment, SXBXP combined with conventional treatment showed potent efficacy when it came to the total efficacy rate (OR, 3.88; 95% CI, 2.87, 5.26; ), B-type natriuretic peptide (BNP) (MD = \u221266.95; 95% CI, \u2212108.57, \u221225.34; ), N-terminal pro-brain natriuretic peptide (NT-ProBNP) (MD = \u22120.15; 95% CI, \u22120.21, \u22120.09; ), six-minute walking distance (6-MWD) (MD = 38.57; 95% CI, 28.47, 48.67; ), cardiac output (CO) (MD = 0.84; 95% CI, 0.68, 0.99; ), and Stroke Volume (SV) (MD = 7.43; 95% CI, 4.42, 10.44, ). The pooled subgroup analysis indicated that there was a significant difference between SXBXP plus conventional treatment and conventional treatment alone in short term course (OR = 3.51; 95% CI, 2.28, 5.40; ), in middle period of treatment (OR = 5.01; 95% CI, 2.61, 9.60; ), and in long-term course (OR = 3.77; 95% CI, 2.13, 6.67; ). No serious adverse events or reactions were mentioned in these RCTs. Conclusions. As an adjuvant drug, this study suggested that SXBXP provide an obvious efficacy for the treatment of CHF. However, due to small samples and generally low quality studies being applied in this study, more rigorous and well-designed RCTs are needed to confirm these findings.",
        "keywords": "",
        "authors": [
            {
                "name": "Taiwei Dong",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Jian Wang",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Xiao Ma",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Rong Ma",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Jianxia Wen",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Nian Chen",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Qian Xie",
                "org": "School of Pharmacy, Ministry of Education, Key Laboratory of Standardization of Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            }
        ],
        "venue": "Evidence-based Complementary and Alternative Medicine",
        "year": 2018
    },
    "2ulqSGb9": {
        "id": "2ulqSGb9",
        "title": "Therapeutic efficacy and safety of Shexiang Baoxin Pill combined with trimetazidine in elderly patients with heart failure secondary to ischaemic cardiomyopathy: A systematic review and meta-analysis.",
        "abstract": "This work provides evidence of the benefit of SBP combined with trimetazidine for the treatment of HF secondary to ICM. More high quality and well-designed RCTs are needed to confirm these findings.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianxia Wen",
                "org": "Department of Pharmacy, 302 Military Hospital of People's Liberation Army, Beijing."
            },
            {
                "name": "Xiao Ma",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu."
            },
            {
                "name": "Lu Zhang",
                "org": "College of Pharmacy, Zhejiang University of Chinese Medicine, Zhejiang, Hangzhou, China."
            },
            {
                "name": "Xiaohua Lu",
                "org": "Department of Pharmacy, 302 Military Hospital of People's Liberation Army, Beijing."
            },
            {
                "name": "Yuxue Yang",
                "org": "Department of Pharmacy, 302 Military Hospital of People's Liberation Army, Beijing."
            },
            {
                "name": "Jian Wang",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu."
            },
            {
                "name": "Yanling Zhao",
                "org": "Department of Pharmacy, 302 Military Hospital of People's Liberation Army, Beijing."
            }
        ],
        "venue": "Medicine",
        "year": 2018
    },
    "EI2reCbQ": {
        "id": "EI2reCbQ",
        "title": "Preclinical Evidence and Mechanism of Xingnaojing Injection for Cerebral Ischemia: A Systematic Review and Meta-Analysis of Animal Studies",
        "abstract": "Objectives. Cerebral ischemia can cause severe harm to people\u2019s health with the characteristics of high incidence, high disability, and high mortality. Xingnaojing injection (XNJI) is widely used in the treatment of cerebral ischemia. The aim of this review is to evaluate the efficacy and mechanism of XNJI in animal models of cerebral ischemia. Methods. Total seven electronic databases in English or Chinese (CNKI, Wanfang, VMIS, PubMed, MEDLINE, Embase, and the Cochrane Library) about most experiments and studies which came out before June 2018 of XNJI for cerebral ischemia have been searched. Data extraction, quality assessment, and meta-analysis are conducted according to the Cochrane standards and RevMan 5.3 software. Results. We have identified 23 eligible studies and made a meta-analysis based on these studies. Meta-analysis shows that XNJI contributes significantly to reduction in neurological deficit score (P = 0.0002, MD = \u22121.25, 95% CI: \u22121.92, \u22120.58) compared with the control group of cerebral ischemia. Subgroup analytic results demonstrate that XNJI has been more effective in animal model of cerebral ischemia-reperfusion injury (P = 0.009, MD = \u22121.35, 95%CI: \u22122.36, \u22120.34) than that of permanent cerebral ischemia (P = 0.0002, MD = \u22121.08, 95%CI: \u22121.66, \u22120.51). Compared with control group, XNJI could remarkably reduce cerebral infarction area (P u003c 0.00001, MD = \u221214.98, 95%CI: \u221221.36, \u22128.59), brain edema (P u003c 0.00001, MD = \u22124.64, 95%CI: \u22125.38, \u22123.90), and neuronal cell apoptosis (P u003c 0.0001, MD = \u221212.21, 95%CI: 18.05, \u22126.37). Meanwhile, the meta-analysis shows that XNJI has a significant anti-inflammatory effect, and the levels of TNF-\u03b1, IL-6, and IL-1\u03b2 are significantly reduced by XNJI (P = 0.001, MD = \u22124.13, 95%CI:\u22126.68, \u22121.58; P u003c 0.00001, MD = \u2212119.23, 95%CI: \u2212138.04, \u2212100.43; P = 0.21, MD = \u2212228.69, 95% CI: \u2212586.20, 128.83). Additionally, XNJI could raise the bodyu0027s antioxidant function and the level of SOD and GSH-Px (P = 0.002, MD = 53.02, 95% CI: \u221220.52, 85.78; P = 0.01, MD = 8.65, 95% CI: 1.77, 15.48) and decrease the level of MDA (P u003c 0.00001, MD = \u22124.16, 95% CI: \u22125.50, \u22122.82). Conclusion. XNJI might be effective in cerebral ischemia by regulating oxidative stress and inflammatory reaction.",
        "keywords": "",
        "authors": [
            {
                "name": "Rong Ma",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Xiao Ma",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Jianxia Wen",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Jian Wang",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Qian Xie",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Nian Chen",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            },
            {
                "name": "Taiwei Dong",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China"
            }
        ],
        "venue": "Evidence-based Complementary and Alternative Medicine",
        "year": 2018
    },
    "oSnxmRhF": {
        "id": "oSnxmRhF",
        "title": "The protective roles of L-borneolum, D-borneolum and synthetic borneol in cerebral ischaemia via modulation of the neurovascular unit.",
        "abstract": "The three kinds of borneol demonstrated different protective effects on cerebral ischaemia injury. L-Borneolum displayed the most prominent anti-cerebral ischaemia effect among them. The mechanism was most likely executed via anti-apoptosis and anti-inflammation effects and maintenance of the stability of the BBB and TJs to comprehensively improve NVU function.",
        "keywords": [
            "Borneol",
            "Cerebral ischaemia",
            "Neurovascular unit",
            "pMCAO"
        ],
        "authors": [
            {
                "name": "Taiwei Dong",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Nian Chen",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Xiao Ma",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Jian Wang",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address: jianwang08@163.com."
            },
            {
                "name": "Jing Wen",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Qian Xie",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Rong Ma",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
        "year": 2018
    },
    "W2BkfnMq": {
        "id": "W2BkfnMq",
        "title": "Paeoniflorin attenuates ANIT-induced cholestasis by inhibiting apoptosis in vivo via mitochondria-dependent pathway.",
        "abstract": "Apoptosis induced by the bile acids in the liver is considered to play a pivotal role in the pathogenesis of cholestatic disease. Increasing evidence has demonstrated that Paeoniflorin (PF) exerts therapeutic effect on severe cholestatic liver diseases. However, whether PF could protect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis by inhibiting apoptosis remains unclear. In this study, we mainly investigated the effect and anti-apoptosis mechanism of PF on cholestasis. Experimental results indicated that PF pretreatment could attenuate liver damage and cholestasis by ANIT in rats, lift the biliary excretion in addition to decrease serum indices (ALT, AST, DBIL, TBIL, TBA, ALP and \u03d2-GT) and conspicuous neutrophil infiltration and cell apoptosis in liver evidenced by TUNEL staining. Furthermore, the pro-apoptosis genes expression of Bax, Caspase-9 and Caspase-3 increased by ANIT were prominently reduced after PF treatment. The increase of anti-apoptosis gene and main regulator Bcl-2 in mitochondria by ANIT was largely reversed by PF pre-treatment. In summary, our study demonstrated that PF pre-treatment not only significantly attenuated ANIT-induced cholestasis and liver injury, but also largely reduced cell apoptosis in liver, thus may act as a potential therapeutic agent for cholestasis disease.",
        "keywords": [
            "ANIT",
            "Apoptosis",
            "Cholestasis",
            "Mitochondria signaling pathway",
            "Peaoniflorin"
        ],
        "authors": [
            {
                "name": "Hou-Qin Zhou",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Department of Pharmacy, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Wei Liu",
                "org": "Department of Respiration, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Jian Wang",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Yin-Qiu Huang",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; Department of Pharmacy, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Peng-Yan Li",
                "org": "China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Yun Zhu",
                "org": "Department of Integrative Medical Center, 302 Military Hospital of People's Liberation Army, Beijing, China."
            },
            {
                "name": "Jia-Bo Wang",
                "org": "China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Xiao Ma",
                "org": "Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China."
            },
            {
                "name": "Rui-Sheng Li",
                "org": "Experimental Laboratory Center, 302 Military Hospital of People's Liberation Army, Beijing, China."
            },
            {
                "name": "Shi-Zhang Wei",
                "org": "Department of Pharmacy, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Kun Li",
                "org": "Department of Pharmacy, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Hao-Tian Li",
                "org": "Department of Pharmacy, 302 Military Hospital of China, Beijing 100039, China."
            },
            {
                "name": "Jian-Yu Li",
                "org": "Department of Integrative Medical Center, 302 Military Hospital of People's Liberation Army, Beijing, China."
            },
            {
                "name": "Xiao-He Xiao",
                "org": "China Military Institute of Chinese Medicine, 302 Military Hospital of China, Beijing 100039, China. Electronic address: xiaoxiaohe302@126.com."
            },
            {
                "name": "Yan-Ling Zhao",
                "org": "Department of Pharmacy, 302 Military Hospital of China, Beijing 100039, China. Electronic address: zhaoyl2855@126.com."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
        "year": 2017
    },
    "ZAlEjsu4": {
        "id": "ZAlEjsu4",
        "title": "Meta-Analysis for Clinical Evaluation of Xingnaojing Injection for the Treatment of Cerebral Infarction",
        "abstract": "Objective: Xingnaojing injection (XNJ) is derived from An-gong-niu-huang pill, a well-known traditional Chinese patent medicine, which is wildly used for stroke. To evaluation the therapeutic effect of XNJ on cerebral infarction, an extensive meta-analysis was used. Methods: Six major electronic databases including the Chinese Biomedical Database (CBM), Wanfang, the VIP medicine information system (VMIS) and the China National Knowledge Infrastructure (CNKI), PubMed, Embase, and the Cochrane Library were examined to retrieve randomized controlled trials designed to evaluate the clinical ef\ufb01cacy of XNJ in treating CI before November 26, 2016. Results: There were fifty-three randomized controlled trials with 4915 participants in this study. The results reflected that compared with the conventional therapy (CT) alone, XNJ could significantly improve the overall response rate (OR=3.56, 95%CI [2.94, 4.32], Pu003c0.00001), and clinical symptom (including increasing activities of daily living (ADL, MD=10.23, 95%CI [9.47, 10.99], Pu003c0.00001), and reduce infarction size (MD=-1.83, 95%CI [-2.49, -1.16], Pu003c0.00001)). However, there was no significant difference between the XNJ treatment and conventional therapy in Glasgow Coma Scale (GCS, P=0.32). Neurological deficit score demonstrated that XNJ could significantly reduce the score in two different evaluation criterions as National Institutes of Health Stroke Scale (NIHSS, MD=-3.44, 95%CI [-4.52, -2.36], Pu003c0.00001), and the Chinese Stroke Scale (CSS, MD=-5.72, 95%CI [-6.94, -4.50], Pu003c0.00001)). Additionally, serum MMPs, including MMP-2 and MMP-9 were significantly reduced by XNJ treatment compared with conventional therapy (MD=-11.24, 95%CI [-20.83, -1.65], P=0.02; MD=-25.08, 95%CI [-35.49, -14.67], Pu003c0.00001, respectively). Moreover, XNJ was able to improve hemorrheology in reducing whole blood viscosity, plasma viscosity, and hematocrit (MD=-1.44, 95%CI [-2.18, 0.70], P=0.001; MD=-0.22, 95%CI [-0.37, -0.07], P=0.003; MD=-3.63, 95%CI [-6.23, -1.03], P=0.006, respectively). The therapeutic efficacy of XNJ was found associated with improving hemodynamics (increasing peak-flow rate, and average velocity) (MD=12.66, 95%CI [10.50, 14.81], Pu003c0.00001; MD=9.90, 95%CI [8.63, 11.17], Pu003c0.00001). XNJ was also related to reducing cholesterol and triglyceride (MD=-1.06, 95%CI [-1.21, -0.92], Pu003c0.00001; MD=-1.05, 95%CI [-1.12, -0.97], Pu003c0.00001). Conclusion: Despite the sample size and the poor quality of the included studies of this review, the results of the research showed that XNJ might be a beneficial therapeutic method for the treatment of cerebral",
        "keywords": "",
        "authors": [
            {
                "name": "Xiao Ma",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Yu X. Yang",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Nian Chen",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Qian Xie",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Tao Wang",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            },
            {
                "name": "Xuan He",
                "org": "Department of Pharmacy, Xindu District Shibantan Public Hospital, Chengdu, China"
            },
            {
                "name": "Jian Wang",
                "org": "College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China"
            }
        ],
        "venue": "Frontiers in Pharmacology",
        "year": 2017
    },
    "QcL4wa4v": {
        "authors": [
            {
                "name": "Dongdong Cao",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "He Li",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Jianyong Yi",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Jingjing Zhang",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Huilian Che",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Jiankang Cao",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Liu Yang",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Chunqiu Zhu",
                "org": "College of Food Science and Nutritional Engineering"
            },
            {
                "name": "Weibo Jiang",
                "org": "College of Food Science and Nutritional Engineering"
            }
        ],
        "title": "Antioxidant properties of the mung bean flavonoids on alleviating heat stress",
        "abstract": "Background: It is a widespread belief in Asian countries that mung bean soup (MBS) may afford a protective effect against heat stress. Lack of evidence supports MBS conferring a benefit in addition to water. Results: Here we show that vitexin and isovitexin are the major antioxidant components in mungbean (more than 96% of them existing in the bean seed coat), and both of them could be absorbed via gavage into rat plasma. In the plasma of rats fed with mungbean coat extract before or after exposure to heat stress, the levels of malonaldehyde and activities of lactate dehydrogenase and nitric oxide synthase were remarkably reduced; the levels of total antioxidant capacity and glutathione (a quantitative assessment of oxidative stress) were significantly enhanced. Conclusions: Our results demonstrate that MBS can play additional roles to prevent heat stress injury. Characterization of the mechanisms underlying mungbean beneficial effects should help in the design of diet therapy strategies to alleviate heat stress, as well as provide reference for searching natural medicines against oxidative stress induced diseases. \u00a9 2011 Cao et al.",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2011,
        "id": "QcL4wa4v"
    },
    "rFSfIgoq": {
        "authors": [
            {
                "name": "Yulin Li",
                "org": "Key Laboratory of Animal Genetics and Breeding"
            },
            {
                "name": "Xuping Zhu",
                "org": "Key Laboratory of Animal Genetics and Breeding"
            },
            {
                "name": "Liu Yang",
                "org": "Key Laboratory of Animal Genetics and Breeding"
            },
            {
                "name": "Junying Li",
                "org": "National Engineering Laboratory for Animal Breeding"
            },
            {
                "name": "Zhengxing Lian",
                "org": "Key Laboratory of Animal Genetics and Breeding"
            },
            {
                "name": "Ning Li",
                "org": "State Key Laboratory of Agrobiotechnology"
            },
            {
                "name": "Xuemei Deng",
                "org": "Key Laboratory of Animal Genetics and Breeding"
            }
        ],
        "title": "Expression and network analysis of genes related to melanocyte development in the Silky Fowl and White Leghorn embryos",
        "abstract": "Silky Fowl is a natural mutant with hyperpigmentation of various internal tissues. Although the mechanism of hyperpigmentation remains unclear, recent studies have shown that the abnormal migration of melanoblast and the absence of environmental barrier molecules are responsible for the hyperpigmentation in Silky Fowl. In this study, 13 genes related to melanocyte development were selected to detect expression changes between Silky Fowl and White Leghorn [including SRY-box 10 (Sox10), paired box (Pax3), stem cell factor (Scf), v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (Kit), endothelin type-B receptor (Ednrb), endothelin 3 (Edn3), microphthalmia-associated transcription factor (Mitf), tyrosinase (Tyr), tyrosinase-related protein-1 (Trp1), tyrosinase-related protein-2 (Trp2), melanocortin-1 receptor (Mc1r), Agouti-related proteins (Agrp), and Proopiomelanocortin (Pomc)]. Transcript expression was detected in 11 stages from 2.5 to 15 days of incubation. In these embryonic periods, Mitf, Kit, Scf, and Agrp expressed earlier in Silky Fowl than in White Leghorn. Sox10, Ednrb, Kit, Mc1r, and Agrp, associating with the proliferation and differentiation of melanoblast, expressed higher (P < 0.05) in Silky Fowl than White Leghorn during 5-6 days of incubation. After day 8 of incubation, Mitf, Tyr, Trp1, Trp2, and Mc1r expressed higher (P < 0.05) in Silky Fowl than White Leghorn, while Agrp expressed higher (P < 0.05) in White Leghorn than Silky Fowl. Moreover, a regulatory network for melanocyte development was constructed based on the expression data. The network predicted novel regulatory relationships and confirmed relationships that have been reported. These results provide biological insight into the molecular mechanism of hyperpigmentation in the Silky Fowl. However, further investigation is needed to confirm these regulatory relationships. \u00a9 2010 Springer Science+Business Media B.V.",
        "keywords": [
            "Chicken embryo",
            "Expression profiles",
            "Melanocyte",
            "Silky Fowl"
        ],
        "venue": "Molecular Biology Reports",
        "year": 2011,
        "id": "rFSfIgoq"
    },
    "G7MFZwBz": {
        "authors": [
            {
                "name": "Xiong-Hui Feng",
                "org": "School of Geosciences and Info-Physics"
            },
            {
                "name": "Zi-Qiang Zhu",
                "org": "School of Geosciences and Info-Physics"
            },
            {
                "name": "Zhi-Yong Li",
                "org": "Hunan Communication Research Institute"
            },
            {
                "name": "Xin Wu",
                "org": "Hunan Communication Research Institute"
            }
        ],
        "title": "The hydration heat analysis for sealing concrete of swivel construction open thin wall arch",
        "abstract": "The sealing concrete of arch bridge will be constructed after swivel construction of it finished. The concrete has such characteristics like huge size, smaller heat radiating area and more complex boundary constraint. According to the cracking situation of this type bridges in recent years, the paper established hydration heat simulation model of it using MIDAS2010 program and numerical analyzed for the model. The hydration heat constant coefficients and placing temperature of the concrete hydration heat effect have been analyzed by simulation parameters base on that. And the results showed that it is an important reason causing the cracking of the concrete. \u00a9 (2013) Trans Tech Publications, Switzerland.",
        "keywords": [
            "Hydration heat analysis",
            "Sealing concrete",
            "Swivel construction"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2013,
        "id": "G7MFZwBz"
    },
    "uQIItkcJ": {
        "authors": [
            {
                "name": "Z. Wu",
                "org": "School of Mathematics and Statistics"
            }
        ],
        "title": "Generation of the Ahlfors five islands theorem",
        "abstract": "By using the Ahlfors theory of covering surface, a normality criterion for families of meromorphic functions is proved. The normality criteri on extends the Ahlfors's five islands theorem. \u00a9 2010 Iranian Mathematical Society.",
        "keywords": [
            "Covering surface",
            "Multiple values",
            "Normality criterion"
        ],
        "venue": "Bulletin of the Iranian Mathematical Society",
        "year": 2010,
        "id": "uQIItkcJ"
    },
    "ojP3XvEA": {
        "authors": [
            {
                "name": "Z. Wu",
                "org": "Department of Mathematics"
            },
            {
                "name": "Y. Chen",
                "org": "Department of Mathematics"
            }
        ],
        "title": "Uniqueness of meromorphic functions dealing with multiple values in an angular domain",
        "abstract": "This paper uses the Tsuji's characteristic to investigate the uniqueness of transcendental meromorphic functions with shared values in an angular domain dealing with the multiple values which improve a result of J. Zheng. \u00a9 2012 Iranian Mathematical Society.",
        "keywords": [
            "Angular domain",
            "Multiple values",
            "Tsujis characteristic",
            "Uniqueness"
        ],
        "venue": "Bulletin of the Iranian Mathematical Society",
        "year": 2012,
        "id": "ojP3XvEA"
    },
    "NhR6pXa7": {
        "authors": [
            {
                "name": "Li-Jie Dong",
                "org": "State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences"
            },
            {
                "name": "Zhi-Qiang Tan",
                "org": "State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences"
            },
            {
                "name": "Ming Chen",
                "org": "State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences"
            },
            {
                "name": "Jing-Fu Liu",
                "org": "State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences"
            }
        ],
        "title": "Hollow fiber supported liquid membrane coupled with high performance liquid chromatography for highly sensitive determination of bisphenols in environmental water samples",
        "abstract": "Hollow fiber supported liquid membrane (HFSLM) was applied for the extraction of bisphenols (BPs), including bisphenol S, bisphenol AF, tetramethylbisphenol A, tetrachlorobisphenol A and tetrabromobisphenol A from water samples. The undecane solution of 1.0% (m/v) tri-n-octylphosphine oxide was supported on the pores of the polypropylene hollow fiber membranes (280 \u03bcm i.d., 50 \u03bcm wall thickness, 0.1 \u03bcm pore size, 60 cm length) to form a liquid membrane. The lumen of the hollow fiber membranes was then filled with 0.3 M NaOH as an acceptor to prepare the extraction device, which was placed into a 500 mL water sample (donor) adjusted to pH 4.0 with HCl. After shaking at 200 rpm for 180 min, the acceptor (\u223c30 \u03bcL) was collected and injected into the high performance liquid chromatography system for the determination of the BPs. The proposed HFSLM method provided good enrichment factors (1370-2138), low detection limits (0.1-0.2 \u03bcg L",
        "keywords": [
            ""
        ],
        "venue": "Analytical Methods",
        "year": 2015,
        "id": "NhR6pXa7"
    },
    "KuRSjqo9": {
        "authors": [
            {
                "name": "Yu-Sen Huo",
                "org": "Department of Physics, Beijing Jiaotong University"
            },
            {
                "name": "Di Wu",
                "org": "Department of Physics, Beijing Jiaotong University"
            },
            {
                "name": "Deng Wei",
                "org": "Department of Physics, Beijing Jiaotong University"
            },
            {
                "name": "Hua Xue",
                "org": "Department of Physics, Beijing Jiaotong University"
            },
            {
                "name": "Ya-Ping Wang",
                "org": "Department of Physics, Beijing Jiaotong University"
            },
            {
                "name": "Yong-Ping Teng",
                "org": "Department of Physics, Beijing Jiaotong University"
            }
        ],
        "title": "Research on propagation characteristics of guided wave in rail excited by low-frequency piezoelectric transducer",
        "abstract": "This short paper introduced the piezoelectric sandwich transducer and obtained the vibration ratio between the front and back metal covers according to the electromechanical equivalent circuit derived by force and electric analogy method. The transducer's resonance frequency is calculated using MATLAB programming, following by an experiment performed on a 1.5m long 50kg / m rail under laboratory conditions. The rail's equivalent damped loss factor was measured and the attenuation curve was plotted using a sandwich transducer and a 352C33 low frequency acceleration sensor as excitation and receiving units respectively.",
        "keywords": [
            "Damped loss factor",
            "Decay rate of rail",
            "Guided wave",
            "Piezoelectric transducer",
            "Sandwich transducer"
        ],
        "venue": "Proceedings of the 2014 Symposium on Piezoelectricity, Acoustic Waves and Device Applications, SPAWDA 2014",
        "year": 2014,
        "id": "KuRSjqo9"
    },
    "LUFMicLn": {
        "id": "LUFMicLn",
        "title": "Assessment of left ventricular systolic synchronicity in patients with heart failure by real-time three-dimensional echocardiography",
        "abstract": "Objective To assess left ventricular systolic synchronicity by real-time three-dimensional echocardiography in patients with heart failure(HF).Methods Twenty-one patients of HF with abnormal wall motion(HF group) and twenty normal subjects(control group) were examined by real-time three-dimensional echocardiography,the global and regional volume-time curves were calculated by Qlab software(version 4.2).The lef ventricular end diastolic volume(LVEDV) and lef ventricular end systolic volume(LVESV) of left ventricle,left ventricular ejection fraction (LVEF),the time to minimal systolic volume of 16,12,6-segmental standard deviation(Tmsv 16-SD, Tmsv 12-SD,Tmsv6-SD),maximal difference(Tmsvl6-Dif,Tmsvl2-Dif,Tmsv6-Dif) were derived. The above parameters as percentages of the cardiac cycle with different heart rates between patients also calculated by the software,which were Tmsvl6-SD%,Tmsvl2-SD%,Tmsv6-SD%, Tmsv 16-Dif%,Tmsv 12-Dif%,Tmsv 6-Dif%respectively.Results LVEF,LVEDV,LVESV, Tmsv16-SD,Tmsv12-SD,Tmsv6-SD,Tmsv16-Dif,Tmsv12-Dif,Tmsv6-Dif were significantly different between the two groups(P<0.05).Conclusion Real-time three-dimensional echocardiography's volume-time curves can be used to evaluate left ventricular global and segmental volume, wall motion,function and systolic synchrony.Tmsv 16,12,6-SD,Tmsvl6,12,6-Dif were potential parameters for assessing left ventricular systolic synchronicity.",
        "keywords": [
            "ventricular function",
            "three-dimensional",
            "left",
            "heart failure",
            "echocardiography",
            "prognosis"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": "Department of Cardiolory,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HUA Qi",
                "org": "Department of Cardiolory,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Cai-rong",
                "org": "Department of Cardiolory,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Geriatric Heart Brain and Vessel Diseases",
        "year": 2011
    },
    "dCNegU9Z": {
        "id": "dCNegU9Z",
        "title": "Clinical and Echocardiographic Characteristics in 1137 Patients with Acute Myocardial Infarction",
        "abstract": "Objective To investigate clinical and echocardiographic characteristics in patients with acute myocardial infarction(AMI).Methods 1 137 patients with AMI were analyzed in clinical terms of characteristics and echocardiographic menifestations.Results Left ventricular remolding and impaired cardiac function were found less compared with elderly patients in young patients with AMI,and more males than females in this group.Male patients with AMI were about equal to female in elderly patients with AMI.Symptoms of elderly patients with AMI were not typical.And high incidence in left ventricular remolding and left ventricular dysfunction was discovered in elderly patients with AMI.Symptoms in 40~74 years old group displayed between young and elder patients with AMI in clinic.Conclusion Young patients with AMI have good prognosis.Severe abnormalities in cardiac structure and function are observed in elderly patients with AMI.Elderly patients with AMI have poor prognosis.",
        "keywords": [
            "echocardiography",
            "acute myocardial infarction"
        ],
        "authors": [
            {
                "name": "Gao Jing",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Hua Qi",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Sang Cheng",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Fan Zhenxing",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Wang Cairong",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital University of Medical Sciences"
            }
        ],
        "venue": "Journal of Capital University of Medical Sciences",
        "year": 2006
    },
    "theocDO3": {
        "id": "theocDO3",
        "title": "The effect of Valsartan on Hypertension and Hypertrophy of left ventricle",
        "abstract": "Objective To study the effect of Valsartan on Hypertension and Hypertrophy of left ventricle.Methods 40 patients with mild or moderate essential hypertension were received Valsartan 80 mg/d for 4 weeks. Ambulatory blood pressure monitoring and echocardiography were measured before and after treatment.Results The blood pressure decreased at fourth week. And LVMI was also decreased in patients with essential hypertension.Conclusion Valsartan is an effective drug to treat mild or moderate essential hypertension. And hypertrophy of left ventricle can be improved with Valsartan in short term.",
        "keywords": [
            "Hypertrophy of left ventricle",
            "Essential hypertension",
            "Valsartan"
        ],
        "authors": [
            {
                "name": "LIU Miao",
                "org": ". Department of Cardiology, Xuanwu Hospital, Beijing , China."
            },
            {
                "name": "GAO Jing",
                "org": ". Department of Cardiology, Xuanwu Hospital, Beijing , China."
            },
            {
                "name": "HUA Qi",
                "org": ". Department of Cardiology, Xuanwu Hospital, Beijing , China."
            }
        ],
        "venue": "Journal of Clinical and Experimental Medicine",
        "year": 2008
    },
    "vOouZ8Tr": {
        "id": "vOouZ8Tr",
        "title": "Comparison of Doppler tissue imaging with pulsed-wave Doppler in evaluation of diastolic function in hypertension patients",
        "abstract": "Objective To identify diastolic dysfunction of pseudonormal pattern of left ventricle in hypertensives by Doppler tissue imaging(DTI).Methods The mitral inflow and pulmonary venous flow were detected in hypertensive patients with pseudo-normal pattern of diastolic dysfunction and normal volunteers.The transmitral peak rapid filling velocity(E) and peak atrial filling velocity(A) were measured.The pulmonary venous peak systolic(S) and diastolic(D) flow velocities and peak reverse flow velocity due to left atrial systole(Ar) were recorded.At the same time,The peak diastolic velocities of mitral annulus during the early phase of diastole(Ea) and the late phase of diastole(Aa) were measured by Doppler tissue imaging.Results There were no differences in E,A,E/A between normal subjects and patients with hypertension.Compared with control group,S and Ar were higher and the average Ea was lower in patients with hypertension.However,the average Aa was similar in normal subjects and in patients with hypertension.Conclusion The average Ea can identify left ventricular diastolic dysfunction of pseudo-normal pattern in hypertension.",
        "keywords": [
            "blood flow velocity",
            "ventricular function",
            "pulsed",
            "hypertension",
            "ultrasonography",
            "left",
            "Doppler"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": "Department of Cardiology,Xuan Wu hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HUA Qi",
                "org": "Department of Cardiology,Xuan Wu hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Cai-rong",
                "org": "Department of Cardiology,Xuan Wu hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Geriatric Heart Brain and Vessel Diseases",
        "year": 2007
    },
    "AIbHrdZM": {
        "id": "AIbHrdZM",
        "title": "Relation between cardiac function and prognosis in 1 137 patients with acute myocardial infarction",
        "abstract": "Objective To explore relation between ecbocardiographic characteristics and prognosis in 1 137 patients with acute myocardial infarction(AMI). Methods 1 137 patients with AMI were divided into 3 groups(<45y, 45-74y, \u226575y). They were analyzed according to echocardiographic manifestation and complication. Results The proportion of male patients was higher than that of female patients in <45y group,and the proportion of males was decreased with increasing age. The severe complications happened in 8 patients (18.2%) in <45y group,216 patients(23.9%) in 45-74y group and 93 patients(49.5%) in \u226575y group. There was statistical difference among the three groups (P<0.05). Conclusion The patients with AMI in <45y group have good prognosis. However,severe abnormalities in left ventricular function and more complications are observed in \u226575y group patients with AMI,who have poor prognosis.",
        "keywords": [
            "arrhythmia",
            "myocardial infarction",
            "age factors",
            "echocardiography",
            "prognosis"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": "Department of Cardiology,Xuan Wu Hospital.Capital Medical University,Beijing , China"
            },
            {
                "name": "HUA Qi",
                "org": "Department of Cardiology,Xuan Wu Hospital.Capital Medical University,Beijing , China"
            },
            {
                "name": "WANG Cai-rong",
                "org": "Department of Cardiology,Xuan Wu Hospital.Capital Medical University,Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Geriatric Heart Brain and Vessel Diseases",
        "year": 2009
    },
    "FRVFNwZ4": {
        "id": "FRVFNwZ4",
        "title": "Analysis of the occurrence of patent foramen ovale in young patient with ischemic stroke",
        "abstract": "Objective To investigate the occurrence of patent foramen ovale (PFO) in young patients with ischemic stroke. Methods A total of 127 young patients with ischemic stroke were admitted to the inpatient department of XuanWu Hospital, Capital Medical University from July 2008 to July 2010. They were divided into a PFO group (n =77) and a non-PFO group (n=50) by transesophageal echocardiography(TEE). Results Patients in the PFO group were younger than those in the non-PFO group (34 \u00b112 vs. 40 \u00b110), the difference was statistically significant (P < 0.05). PFO group had lessstroke related risk factors than those of the non-PFO group in the, such as hypertension, diabetes mellitus, smoking history of smoking, hypercholesterolemia and Hyperhomocysteinemia. The difference was statistically significant (P < 0.05). The PFO group had less negative pathological changes by TCD and carotid ultrasound than those of the non-PFO group in. Conclusion PFO may be a key factor for ischemic stroke in young patients.",
        "keywords": [
            "Stroke Patent foramen oval Atrial septal aneurysm"
        ],
        "authors": [
            {
                "name": "GUO Hong-chang",
                "org": "Cardiology Center, XuanWu Hospital, Capital Medical University, Beijing "
            },
            {
                "name": "GAO Jing",
                "org": "Cardiology Center, XuanWu Hospital, Capital Medical University, Beijing "
            },
            {
                "name": "WANG Cai-rong",
                "org": "Cardiology Center, XuanWu Hospital, Capital Medical University, Beijing "
            }
        ],
        "venue": "Beijing Medical Journal",
        "year": 2012
    },
    "xUckTrt0": {
        "id": "xUckTrt0",
        "title": "Assessment of left ventricular mass and left atrial function by using real-time three-dimensional echocardiography in patients with hypertension",
        "abstract": "Objective To assess left ventricular mass and left atrial function in patients with hypertension by using real-time three-dimensional echocardiography (RT-3DE).Methods Sixty-six patients with hypertension and thirty seven normal subjects(control group) were enrolled.Hypertensive patients were divided into left ventricular hypertrophy (LVH) group and non-left ventricular hypertrophy(NLVH) group.Philips iE-33 with X3-1 probe was used to perform full volume real-time three-dimensional echocardiography,and then were analyzed offline by Qlab software.The left ventricular mass, left atrial ejection fraction(LAEF) were derived.Results Left ventricular mass increased in LVH group and NLVH group than in control group (P<0.05).And left ventricular mass obtained by M-mode echocardiography was greater than that by RT-3DE.Compared with control group,LAEF decreased in LVH group and NLVH group (P<0.05).Conclusions RT-3DE can evaluate left ventricular mass and left atrial function quantitatively in patients with hypertension.",
        "keywords": [
            "Hypetension",
            "Atrial function",
            "three-dimensional",
            "Echocardiography",
            "left"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": "~*Department of Cardiovascular,Xuanwu Hospital,Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "HUA Qi",
                "org": "~*Department of Cardiovascular,Xuanwu Hospital,Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "LI Jing",
                "org": "~*Department of Cardiovascular,Xuanwu Hospital,Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "WANG Cai-rong",
                "org": "~*Department of Cardiovascular,Xuanwu Hospital,Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "LI Xiao-hui",
                "org": "~*Department of Cardiovascular,Xuanwu Hospital,Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "GAO Cheng-mei",
                "org": "~*Department of Cardiovascular,Xuanwu Hospital,Capital University of Medical Sciences, Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Medicine",
        "year": 2009
    },
    "4joSUa3z": {
        "id": "4joSUa3z",
        "title": "Transesophageal echocardiography to detect right-to-left shunt in neurosurgical patients in the sitting position",
        "abstract": "Objective To evaluate the efficacy of intraoperative transesophageal echocardiography(TEE) to detect right-to-left shunting in patients undergoing neurosurgical procedures while in the sitting position.Methods six patients scheduled for neurosurgery in the sitting position were investigated.venous air embolism(VAE) and paradoxical air embolism(PAE) were continuously monitored by cardiac two-dimensional 4-chamber view using transesophageal echocardiography(TEE).Results Microbubbles in the right atrium appeared in all patients.In 3 patents,air appearance in all cavities of the heart was found.Conclusion TEE would be one of the most important monitoring methods not only in cardiac surgery,but also in neurosurgical procedures in the sitting position.",
        "keywords": [
            "venous air embolism",
            "sitting position",
            "transesophageal echocardiography"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HUA Qi",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Xiao-hui",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Cai-rong",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "MA Ting",
                "org": "Department of Anesthesiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YE Xin",
                "org": "Department of Anesthesiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "Journal of Capital Medical University",
        "year": 2012
    },
    "6vhIOXiV": {
        "id": "6vhIOXiV",
        "title": "Evaluation of Left Ventricular Function of Patients with Coronary Heart Disease by Using Real Time Three Dimensional Echocardiography",
        "abstract": "Objective The effects of coronary heart disease on left ventricular(LV) function have been studied by various echocardiographic techniques(M-mode,2D echocardiography).These studies are hampered by a low accuracy of measurements because of geometric assumptions regarding LV shape.Real time three-dimensional echocardiography(RT-3DE) can overcome this limitation.Methods We detected 80 patients with coronary heart disease by 2D and RT-3D echocardiography.Each one was tested the feasibility of RT-3DE assessment of LV function.Conventional biplane Simpson rule(BSR) for LV function analysis was used as a reference.Paired t test was used for analysis of differences within the variations.Correlation analysis was performed for RT-3DE and 2DE measurements.Results All the patients were studied and in 70 of 80(87.5%) RT-3DE datasets were acquired.In 10 patients,the dataset was of insufficient quality and excluded from analysis.Correlation between BSR and RT-3DE for calculation of end-diastolic volume(EDV,r=0.875),end systolic volume(ESV,r=0.912) and for ejection fraction(EF,r=0.905) was moderate.2DE methods underestimated end diastolic and end-systolic volume,while overestimating ejection fraction.Conclusion RT-3DE is feasible for image acquisition during coronary heart disease,which opens the possibility for accurate and reproducible measurement of LV function.This may improve the assessment of the acute effect of coronary heart disease on LV performance,and guide therapeutic strategies.",
        "keywords": [
            "coronary heart disease",
            "left ventricular function",
            "real time three-dimensional echocardiography"
        ],
        "authors": [
            {
                "name": "Gao Jing",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medicial University"
            },
            {
                "name": "Hua Qi",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medicial University"
            },
            {
                "name": "Wang Cairong",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medicial University"
            },
            {
                "name": "Li Xiaohui",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medicial University"
            },
            {
                "name": "Gao Chengmei",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medicial University"
            }
        ],
        "venue": "Journal of Capital Medical University",
        "year": 2008
    },
    "PlWHK9KW": {
        "id": "PlWHK9KW",
        "title": "Analysis of the occurrence of patent foramen ovale in young patients with ischemic stroke",
        "abstract": "Objective To investigate the occurrence of patent foramen ovale (PFO) in young patients with ischemic stroke.Methods A total of 198 consecutive young patients with ischemic stroke were selected from either the outpatient or inpatient department of Xuanwu Hospital, Capital Medical University from October 2006 to January 2010.They were divided into a PFO group (n = 125) and a non-PFO group (n = 73) according to whether the existence of PFO on tranesophageal echocardiography.The occurrence of PFO was observed by tranesophageal echocardiography and right heart contrast echocardiography. The examinations of the related risk factors were performed in all the patients.Results \u2460The patients in the PFO group were younger than those in the non-PFO group (37 \u00b1 10 vs.43 \u00b1 10).The diffe-rence was statistically significant (P < 0.05).\u2461The stroke-related risk factors,such as the proportions of patients with hypertension, diabetes mellitus, smoking history, and hypercholesterolemia in the PFO group were lower than those in the non-PFO group.The differences were statistically significant (P<0.05).\u2462 Eighteen patients (14.4%) were complicated with atrial septal aneurysm in the PFO group, and only 5 patients(6.8%) in the non-PFO group.The difference was statistically significant (P =0.018).\u2463The proportion of patients without any risk factors in the PFO group was higher than that in the non-PFO group.The difference was statistically significant (P < 0.05).Conclusion PFO may be an important cause of ischemic stroke in young patients.",
        "keywords": [
            "Echocardiograph",
            "atrial",
            "transesophageal",
            "Heart septal defects",
            "Stroke",
            "Brain ischemia"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "HUA Qi",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "WANG Cai-rong",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "LI Jing",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "GAO Cheng-mei",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "LI Xiao-hui",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "LIU Jing",
                "org": ".Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing , China"
            }
        ],
        "venue": "Chinese Journal of Cerebrovascular Diseases",
        "year": 2010
    },
    "bbmc2w17": {
        "id": "bbmc2w17",
        "title": "Impact of age and gender on cardiac structure and function in normal Chinese population]",
        "abstract": "To identify the impact of age and gender on cardiac structure and left ventricular function in normal Chinese by echocardiography.Cardiac structure, valve flow velocity and cardiac function were measured by echocardiography in 15,692 healthy volunteers. Subjects were grouped by age at 5 years interval in population older than 5 years. Children under 5 years were divided into 3 age groups (< 1 years, 1 - 3 years, 4 - 5 years). Hierarchical cluster analyses were performed for ages, based on indexes of cardiac structure and function respectively.Six groups (< 1 years, 1 - 3 years, 4 - 5 years, 6 - 10 years, 11 - 20 years, > or = 21 years) were generated after the age hierarchical cluster analyses based on index of cardiac structure. Four groups (< or = 30 years, 31 - 50 years, 51 - 80 years, > or = 81 years) were generated based on spectral current flow. Six groups (< 1 years, 1 - 3 years, 4 - 5 years, 6 - 10 years, 11 - 15 years, > or = 16 years) were generated based on left ventricular systolic function and five groups (< or = 15 years, 16 - 30 years, 31 - 50 years, 51 - 80 years, > or = 81 years) were generated based on left ventricular diastolic function. Cardiac structure index were similar between male and female in age groups < or = 10 years and significantly lower in females than males in age groups > or = 11 years (P < 0.05). Valve flow velocity was similar between male and female in various age groups (P > 0.05). Left ventricular systolic function was similar between male and female in age groups < or = 10 years but was significantly higher in males than females in age groups > or = 11 years (all P < 0.05). Left ventricular diastolic function was similar between female and male in various age groups (P > 0.05) and equally decreased with aging in both female and male subjects.The cardiac development in Chinese population can be divided in 6 phases and becomes stable in subjects older than 21 years, left ventricular systolic function becomes stable in subjects older than 16 years and the left ventricular diastolic function declines physiologically with aging.",
        "keywords": [],
        "authors": [
            {
                "name": "Li Jing",
                "org": "Department of Cardiology, Beijing Hospital, Beijing 100730, China. leejingabc@sina.com"
            },
            {
                "name": "Liu Yan-ling",
                "org": ""
            },
            {
                "name": "He Qing",
                "org": ""
            },
            {
                "name": "Hua Qi",
                "org": ""
            },
            {
                "name": "Xue Hong-qi",
                "org": ""
            },
            {
                "name": "Gao Jing",
                "org": ""
            },
            {
                "name": "Wang Jian-peng",
                "org": ""
            },
            {
                "name": "L\u00fc Xiu-zhang",
                "org": ""
            },
            {
                "name": "Zhu Zhen-hui",
                "org": ""
            },
            {
                "name": "Ling Yan",
                "org": ""
            },
            {
                "name": "Fan Hai-rong",
                "org": ""
            },
            {
                "name": "Wang Chuan-yu",
                "org": ""
            }
        ],
        "venue": "Zhonghua xin xue guan bing za zhi",
        "year": 2010
    },
    "YRKH3gsZ": {
        "id": "YRKH3gsZ",
        "title": "The correlation between enlarged left atrium and decreased left ventricular diastolic function by echocardiography in healthy subjects",
        "abstract": "Objective To investigate the correlation between enlarged left atrium and decreased left ventricular diastolic function in healthy subjects. Methods The cardiac structure and left ventricular function were examined by echocardiography in 4575 healthy volunteers. The subjects were divided into 8 groups according to their ages. The early peak flow velocity (EPFV),atrium peak flow velocity (APFV), left ventricular ejection fraction(LVEF), diameter of left atrium (LAD)and end diastolic diameter of left ventricle (EDD) were measured. The relationships between age and cardiac structure, left ventricular function were calculated. Results There were no differences in LVEF and EDD in different age groups. With increasing age,LAD enlarged, EPFV decreased and APFV increased. The ratio between EPFV and APFV (E/A) significantly decreased (P <0.05 between every two groups except the group aged over 80 years). There were significant positive correlation between LAD and EPFV and negative correlation between LAD and APFV (P <0.01). Conclusions Age is one of the important physiologic factors influencing the diameter of left atrium and left ventricular diastolic function. There was good correlation between enlarged left atrium and decreased left ventricular diastolic function with increasing age. It is suggested that enlarged left atrium is an important indicator for predicting decreased left ventricular diastolic function.",
        "keywords": [
            "age",
            "left",
            "left atrium",
            "echocardiography",
            "normal subject",
            "ventricular diastolic function"
        ],
        "authors": [
            {
                "name": "HUA Qi",
                "org": ", et al Cardiovascular Department, Xuanwu Hospital, Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "GAO Jing",
                "org": ", et al Cardiovascular Department, Xuanwu Hospital, Capital University of Medical Sciences, Beijing ,China"
            },
            {
                "name": "WANG Cairong",
                "org": ", et al Cardiovascular Department, Xuanwu Hospital, Capital University of Medical Sciences, Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Multiple Organ Diseases in the Elderly",
        "year": 2006
    },
    "oTnCC0oM": {
        "id": "oTnCC0oM",
        "title": "Clinical research on atherosclerosis in patients with impaired glucose regulation",
        "abstract": "Objective To observe the changes of atherosclerosis indexes in patients with impaired glucose regulation(IGR) and to investigate their relation to atherosclerotic risk factors.Methods A total of 31 newly diagnosed type 2 diabetes mellitus(DM) patients,286 IGR patients including 36 isolated impaired fasting glycaemia(I-IFG),108 isolated impaired glucose tolerance(I-IGT) and 142 IFG + IGT,another 102 healthy controls matched for age and sex were enrolled in the study.The clinical data including age,sex,smoking,body mass index,blood pressure,fasting and postprandial 2 hours blood glucose(OGTT),fasting lipid,fasting insulin and waist hip ratio(W/R) were collected. Intimal-medial thickness(IMT),carotid-femoral pulse wave velocity(cfPWV) and ankle-brachial index(ABI) were detected.Results The basic data of the five groups were similar(all P>0.05).Compared to the control group,the other 4 groups had higher BMI,W/R and ISI(all P<0.05),but no significances were found among them(all P>0.05). Compared to the control group,IFG + IGT,I-IGT and DM groups had increasing IMT,cfPWV and decreasing ABI(all P<0.05) except I-IFG group(P>0.05).Significance was found in cfPWV between DM and I-IGT group,but not in ABI and IMT.Correlation analysis showed that in I-IGT group,IMT and cfPWV were negatively related to ISI,and positively correlated to BMI and W/R.ABI was positively correlated with ISI,and negatively related to BMI and W/R(all P<0.05 ).Conclusions IMT,cfPWV and ABI are indicators of atherosclerosis in IGR patients,and cfPWV is more sensitive than IMT and ABI,I-IFG may be not risk factor of atherosclerosis.",
        "keywords": [
            "Diabetes mellitus",
            "Pulse",
            "Arteriosclerosis",
            "type 2"
        ],
        "authors": [
            {
                "name": "JIA Ke-bao",
                "org": ".Department of Endocrine,Xuanwu Hospital,Medical University Beijing ,China"
            },
            {
                "name": "WANG Li",
                "org": ".Department of Endocrine,Xuanwu Hospital,Medical University Beijing ,China"
            },
            {
                "name": "WANG Cai-rong",
                "org": ".Department of Endocrine,Xuanwu Hospital,Medical University Beijing ,China"
            },
            {
                "name": "GAO Jing",
                "org": ".Department of Endocrine,Xuanwu Hospital,Medical University Beijing ,China"
            }
        ],
        "venue": "Chinese Journal of Cardiovascular Medicine",
        "year": 2009
    },
    "QgLGwdvo": {
        "id": "QgLGwdvo",
        "title": "Effect of Valsartan on Hypertension and Hypertrophy of Left Ventricle",
        "abstract": "Objective To study the effect of valsartan on hypertension and hypertrophy of left ventricle. Methods Total 40 patients with mild or moderate essential hypertension were received valsartan 80mg/d for 4 weeks. Ambulatory blood pressure monitoring and echocardiography were measured before and after treatment.Results The blood pressure decreased at fourth week. And LVMI was also decreased in patients with essential hypertension.Conclusion Valsartan is an effective drug to treat mild or moderate essential hypertension. And hypertrophy of left ventricle can be improved with valsartan in short term.",
        "keywords": [
            "Hypertrophy of left ventricle",
            "Essential hypertension",
            "Valsartan"
        ],
        "authors": [
            {
                "name": "LIU Miao",
                "org": " Department of Cardiology, Xuanwu Hospital of Shoudu Medical University, Beijing ,China"
            },
            {
                "name": "GAO Jing",
                "org": " Department of Cardiology, Xuanwu Hospital of Shoudu Medical University, Beijing ,China"
            },
            {
                "name": "HUA Qi",
                "org": " Department of Cardiology, Xuanwu Hospital of Shoudu Medical University, Beijing ,China"
            }
        ],
        "venue": "Journal of Medical Forum",
        "year": 2009
    },
    "LMUQChzd": {
        "id": "LMUQChzd",
        "title": "Numerical optimization of flow noises for mufflers based on the improved BP neural network",
        "abstract": "Aimed at the large noise of tail pipe, the method of fluid dynamics was firstly applied to analyze the inner flow field of the exhaust muffler. According to the result, the large noise of tail pipe was mainly caused by air flow regeneration noise, and the vice muffler was not the major component for generating airflow noise. The largest pressure of the whole muffler system was at the outlet end of main mufflers. The largest flow velocity was in the connection pipe between main mufflers and vice mufflers. Secondly, boundary element model of transmission loss for the muffler was established to compare and analyze it with the experimental. The experimental and computational value of transmission loss for the muffler has a good consistency in both change trend and numerical value, and the computational model was reliable. Finally, GA-BP neural network algorithm was used to optimize the acoustic performance of the muffler. Airflow noises of the tail pipe were effectively reduced through optimizing the inner structure of the muffler.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaolin Xie",
                "org": ""
            },
            {
                "name": "Feng Gao",
                "org": ""
            },
            {
                "name": "Xiao-yun Huang",
                "org": ""
            },
            {
                "name": "Chuan Huang",
                "org": ""
            },
            {
                "name": "Jie Li",
                "org": ""
            }
        ],
        "venue": "Journal of Vibroengineering",
        "year": 2016
    },
    "WtDaORVo": {
        "id": "WtDaORVo",
        "title": "Design and development of a new transformable wheel used in amphibious all-terrain vehicles (A-ATV)",
        "abstract": "Abstract   Conventional ground-wheeled vehicles usually have poor trafficability, low efficiency, a large amount of energy consumption and possible failure when driving on soft terrain. To solve this problem, this paper presents a new design of transformable wheels for use in an amphibious all-terrain vehicle. The wheel has two extreme working statuses: unfolded walking-wheel and folded rigid wheel. Furthermore, the kinematic characteristics of the transformable wheel were studied using a kinematic method. When the wheel is unfolded at walking-wheel status, the displacement, velocity and acceleration of the wheel with different slip rates were analyzed. The stress condition is studied by using a classic soil mechanics method when the transformable wheel is driven on soft terrain. The relationship among wheel traction, wheel parameters and soil deformation under the stress were obtained. The results show that both the wheel traction and trafficability can be improved by using the proposed transformable wheel. Finally, a finite element model is established based on the vehicle terramechanics, and the interaction result between the transformable wheel and elastic\u2013plastic soil is simulated when the transformable wheel is driven at different unfold angles. The simulation results are consistent with the theoretical analysis, which verifies the applicability and effectiveness of the transformable wheel developed in this paper.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaolin Xie",
                "org": "Department of Automobile Engineering, Beihang University, Beijing 100191, PR China"
            },
            {
                "name": "Feng Gao",
                "org": "Department of Automobile Engineering, Beihang University, Beijing 100191, PR China"
            },
            {
                "name": "Chuan Huang",
                "org": "Department of Automobile Engineering, Beihang University, Beijing 100191, PR China"
            },
            {
                "name": "Wen Zeng",
                "org": "Department of Automobile Engineering, Beihang University, Beijing 100191, PR China"
            }
        ],
        "venue": "Journal of Terramechanics",
        "year": 2017
    },
    "tJQhkf1Y": {
        "id": "tJQhkf1Y",
        "title": "Particle Density Substitution Method for Trafficability of Soil in Different Gravity Environments",
        "abstract": "By selecting metal powders with comparable particle size class, similar shape and material and almost the same void ratio but different particle densities, the influence of different gravity on the trafficability of soil under different states of gravitational fields is found to be equivalent to the change in particle density. This method is named particle density substitution. The shearing and bearing characteristics of simulated soil were studied. An influence of different factors on the experimental results was achieved, and a minimal influence of factors other than particle density on experimental results was obtained. Regression of shearing and bearing characteristics of the simulated soil was designed. The relationship between particle density and mechanical parameters of soil was fitted with curves. The formulation between particle density and maximal static thrust was established. By analyzing these data, the maximal static thrust slowly decreased with increasing particle density, reached the minimum when particle density was 3 g/cm3, and then sharply increased. This trend is consistent with the theoretical result. It can also certify that the particle density substitution method established here is reasonable.",
        "keywords": [
            "Gravity field",
            " Soil",
            " Particle density",
            " Trafficability"
        ],
        "authors": [
            {
                "name": "Chuan Huang",
                "org": "Beihang University"
            },
            {
                "name": "Feng Gao",
                "org": "Beihang University"
            },
            {
                "name": "Xiaolin Xie",
                "org": "Beihang University"
            },
            {
                "name": "Hui Jiang",
                "org": "Beihang University"
            },
            {
                "name": "Wen Zeng",
                "org": "Beihang University"
            }
        ],
        "venue": "Microgravity Science and Technology",
        "year": 2017
    },
    "6EmOJq67": {
        "authors": [
            {
                "name": "Jie Xiong",
                "org": "State Key Laboratory of Plant Physiology and Biochemistry"
            },
            {
                "name": "Han Lu",
                "org": "State Key Laboratory of Plant Physiology and Biochemistry"
            },
            {
                "name": "Kaixing Lu",
                "org": "State Key Laboratory of Plant Physiology and Biochemistry"
            },
            {
                "name": "Yuxing Duan",
                "org": "State Key Laboratory of Plant Physiology and Biochemistry"
            },
            {
                "name": "Lingyao An",
                "org": "State Key Laboratory of Plant Physiology and Biochemistry"
            },
            {
                "name": "Cheng Zhu",
                "org": "State Key Laboratory of Plant Physiology and Biochemistry"
            }
        ],
        "title": "Cadmium decreases crown root number by decreasing endogenous nitric oxide, which is indispensable for crown root primordia initiation in rice seedlings",
        "abstract": "Cadmium (Cd) is toxic to crown roots (CR), which are essential for maintaining normal growth and development in rice seedlings. Nitric oxide (NO) is an important signaling molecule that plays a pivotal role in plant root organogenesis. Here, the effects of Cd on endogenous NO content and root growth conditions were studied in rice seedlings. Results showed that similar to the NO scavenger, cPTIO, Cd significantly decreased endogenous NO content and CR number in rice seedlings, and these decreases were recoverable with the application of sodium nitroprusside (SNP, a NO donor). Microscopic analysis of root collars revealed that treatment with Cd and cPTIO inhibited CR primordia initiation. In contrast, although SNP partially recovered Cd-caused inhibition of CR elongation, treatment with cPTIO had no effect on CR elongation. l-NMMA, a widely used nitric oxide synthase (NOS) inhibitor, decreased endogenous NO content and CR number significantly, while tungstate, a nitrate reductase (NR) inhibitor, had no effect on endogenous NO content and CR number. Moreover, enzyme activity assays indicated that treatment with SNP inhibited NOS activity significantly, but had no effect on NR activity. All these results support the conclusions that a critical endogenous NO concentration is indispensable for rice CR primordia initiation rather than elongation, NOS is the main source for endogenous NO generation, and Cd decreases CR number by inhibiting NOS activity and thus decreasing endogenous NO content in rice seedlings. \u00a9 2009 Springer-Verlag.",
        "keywords": [
            "Adventitious roots",
            "Cadmium",
            "Crown root",
            "Nitric oxide",
            "Nitric oxide synthase",
            "Oryza"
        ],
        "venue": "Planta",
        "year": 2009,
        "id": "6EmOJq67"
    },
    "j4ErfY9N": {
        "id": "j4ErfY9N",
        "title": "Neural adhesion molecule NECL1 inhibits migration, invasion, and potentially induces differentiation of glioma cell]",
        "abstract": "To explore the influences of the restoration of neural adhesion molecule NECL1 on the morphology, migration, and invasion of NECL1-deficient glioma cell lines.Scratch and Transwell assays were used to observe the cell migration and invasion, the activities of extracellular metalloproteinases were measured, and the cell morphology was observed. Astrocytes marker glial fibrillary acidic protein was detected by Western blot after the restoration of NECL1 in glioma U251 cell line.In NECL1-deficient U251 glioma cell lines, migration and invasion were inhibited. The U251 cells was differentiated potentially to astrocytes, and glial fibrillary acidic protein was up-regulated after the restoration of the NECL1 expression.As a potential tumor repressor, the neural adhesion molecule NECL1 can inhibit the migration and invasion of glioma cell and induces its differentiation.",
        "keywords": [
            "invasion",
            "astrocytes",
            "u251 glioma cell lines",
            "necl1",
            "migration"
        ],
        "authors": [
            {
                "name": "YIN Bin",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "CHEN Tao",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "GAO Jing",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "YUAN Jian-gang",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "PENG Xiao-zhong",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2009
    },
    "1uzBLiRz": {
        "id": "1uzBLiRz",
        "title": "Role of cell adhesion molecules Necl1 in synaptogenesis in primary cultured rat neurons]",
        "abstract": "To study the role of cell adhesion molecules Necl1 in synaptogenesis in primary cultured neurons.Semi-quantitive reverse transcription polymerase chain reaction (RT-PCR) was used to detect the expression pattern of Necl1 in the neuronal differentiation cell model in vitro. Western blot was performed to detect the expression pattern of Necl1 in primary cultured rat neurons and in purified synaptosome. Immunofluoresence was used to detect the synapse formation in primary neurons and in 293 cells co-culture and to detect the density of synapses in primary neuron with ectopic expression of Necl1.Necl1 expression increased after retinoic acid (RA) induction in SH-SY5Y and P19 cells. The increase of Necl1 expression was consistent with the days of primary neurons culture in vitro, and Necl1 partly localized in synaptosome. The overexpression of Necl1 in 293 cells induced the synapse formation between cocultured 293 cells and neurons. Ectopic expression of Necl1 in primary neurons increased the density of synapses.Necl1 plays an important role in neuronal synapse formation.",
        "keywords": [
            "primary cultured neuron",
            "necl1",
            "synaptogenesis"
        ],
        "authors": [
            {
                "name": "CHEN Tao",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "WU Xu-dong",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "GAO Jing",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "HAO Wei",
                "org": "Department of Physiology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "YIN Bin",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "QIANG Bo-qin",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "YUAN Jian-gang",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "GONG Yan-hua",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "PENG Xiao-zhong",
                "org": "National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2008
    },
    "p5SGvdPz": {
        "id": "p5SGvdPz",
        "title": "Effect of NECL1 on the proliferation of T98G glioma cell line]",
        "abstract": "To study the regulation role of tumor suppressor NECL1 on the proliferation of glioma cell line.We detected the expression level of NECL1 in human normal brain tissue and glioma cell lines using semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and Western blot. T98G cell line in which NECL1 was silent and whose transfection efficiency was relatively high as target cell was chosen, and the effect of NECL1 on the proliferation of T98G cell line in vitro was detected by using cell growth curve, flow cytometry, and Hoechst staining.NECL1 was abrogated or markedly reduced in 6 glioma cell lines. When NECL1 was overexpressed in T98G cell line, the cell growth rate obviously decreased and the number of apoptotic cells remarkably increased when compared with the control group.NECL1 may inhibit the proliferation of T98G cells by inducing its apoptosis.",
        "keywords": [
            "glioma",
            "apoptosis",
            "necl1",
            "t98g cell line",
            "proliferation"
        ],
        "authors": [
            {
                "name": "GAO Jing",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "CHEN Tao",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "YIN Bin",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "GONG Yan-hua",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "QIANG Bo-qin",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "YUAN Jian-gang",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            },
            {
                "name": "PENG Xiao-zhong",
                "org": " National Laboratory of Medical Molecular Biology,Institute of Basic Medical Sciences,CAMS and PUMC,Beijing ,China"
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2008
    },
    "HHiQOR63": {
        "authors": [
            {
                "name": "Serick Duysenbi",
                "org": "Department of Neurosurgery"
            },
            {
                "name": "Yu-Hai Bao",
                "org": ""
            },
            {
                "name": "Hao Wen",
                "org": ""
            },
            {
                "name": "Chen Liu",
                "org": ""
            },
            {
                "name": "Dangmurenjiafu Geng",
                "org": ""
            }
        ],
        "title": "Establishment of a rat model of intracranial aneurysm with modified procedure",
        "abstract": "Objective: To evaluate the effect of a modified procedure on the establishment of a model of cerebral aneurysm in rats. Methods: Fifty-five SD rats were randomized into three groups: traditional method (group A, re = 20), modified procedure (group B, n = 20), and control (group C, n = 15). Left common carotid artery and one posterior branch of bilateral renal arteries were ligated in the group A; left carotid artery was ligated and cut off, and bilateral renal arteries were electrocoagulated and cut off (two branches on each side or the one dominant branch of bilateral renal arteries) in the group B; and no intervention was performed in the group C. The rats were fed isosmotic saline and 0.12% beta-aminopropionitrile (BAPN) on the same day after procedure, and were sacrificed four weeks after the procedures. Cerebral arteries were isolated from basal parts of the brain under a microscope. Anterior cerebral artery/olfactory artery (ACA/ OA) bifurcations or a part of artery near the aneurysm were taken out, and their pathological changes were observed under light microscope. Systolic blood pressure was measured by the tail-cuff method before the procedures, 3 weeks after the procedures, and on the same day the rats were sacrificed. Results: Advanced aneurysm was not found on the ACA/OA bifurcations in group A. Six rats died of aneurysmal subarachnoid hemorrhage in group B, and 10 advanced aneurysms were found in the remaining 14 rats. Mean systolic blood pressure were (164.3 \u00b1 3.0) mm Hg, (195.2 \u00b1 1.9) mm Hg, and (116.2 \u00b12.6) mm Hg respectively before the rats were killed in the three groups. Early aneurysmal change in two rats was found in group A, the change consisted of discontinuity of the internal elastic lamina, but no apparent outward bulging of the arterial wall. Sixteen saccular aneurysms were all advanced aneurysms in group B, the breaks in internal elastic lamina, muscular layer becoming thinner and outward bulging of the arterial wall could be visualized under the light microscope; and early aneurysmal change was also found. No aneurysm was detected in group C. Conclusion: The modified procedure can not only shortens the time of aneurysm formation, but also increases the rate of aneurysm formation, which may be associated with the elevation of blood pressure in a short period of time.",
        "keywords": [
            "Animal, model",
            "Hypertension, renovascular",
            "Intracranial aneurysm",
            "Rats"
        ],
        "venue": "Chinese Journal of Cerebrovascular Diseases",
        "year": 2007,
        "id": "HHiQOR63"
    },
    "yteIsEVn": {
        "authors": [
            {
                "name": "Sailike Duishanbai",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Dangmuren Jiafu",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Huairong Guo",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Chen Liu",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Bo Liu",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Maimaitiaili Aishalong",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Maimaitili Mijiti",
                "org": "Neurosurgery Department"
            },
            {
                "name": "Hao Wen",
                "org": "Neurosurgery Department"
            }
        ],
        "title": "Intracranial hydatid cyst in children: Report of 30 cases",
        "abstract": "Purpose To analyze the clinical manifestations, radiological features, and surgical outcomes in 30 pediatric intracranial hydatid cysts. Methods We reviewed the clinical, radiological, and surgical aspects of pediatric intracranial hydatid cysts patients who received surgical treatment at the Neurosurgical department of Xinjiang Medical University between the years 1985 to 2007, retrospectively. Results Headache and vomiting were the most common initial symptoms in our series. Neurological deficits from the mass effect of the cysts were seen in 15 cases, including hemiparesis, visual deficit, and diplopia. Epilepsy occurred only in one patient with temporal lobe hydatid cyst. On computed tomography (CT), it presented as a round-shaped and thin-walled homogeneous low-density cystic lesion without surrounding edema and enhancement. Only five patients had a magnetic resonance imaging (MRI) scan, and presented low signal intensity on T1-weighted image and high signal intensity on T2-weighted image. Surgical removal of cyst was performed in all cases and intact removal was done in 29 cases. However, one cyst ruptured during the dissection of cyst wall, thus, resulting in one death. There were no additional neurological deficits which were caused directly by surgery. Conclusion Increased intracranial pressure is common in patients with cerebral hydatid disease. CT and MRI are the first-line diagnostic procedures. Surgery is the treatment of choice for the majority of intracranial hydatid cysts. Multiple and deep seated lesions should receive medical treatment postoperatively. \u00a9 Springer-Verlag 2009.",
        "keywords": [
            "Children",
            "Intracranial hydatid cysts",
            "Surgery",
            "Treatment"
        ],
        "venue": "Child's Nervous System",
        "year": 2010,
        "id": "yteIsEVn"
    },
    "7CVU4TMN": {
        "authors": [
            {
                "name": "Sailike Duishanbai",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Dangmurenjiafu Geng",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Chen Liu",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Huai-Rong Guo",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Yu-Jun Hao",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Bo Liu",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Yong-Xin Wang",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Kun Luo",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Kai Zhou",
                "org": "Department of Neurosurgery, Research Group of Hydatid Diseases"
            },
            {
                "name": "Hao Wen",
                "org": "State Key Lab Breeding Base of Xinjiang Major Diseases Research"
            }
        ],
        "title": "Treatment of intracranial hydatid cysts sailike duishanbai",
        "abstract": "Background: Echinococcosis is still endemic in many countries, including China, where it is especially prevalent in the northwest. The aim of this study was to enrich the international literature about the treatment of intracranial hydatid cysts. Methods: We retrospectively reviewed the clinical features, radiological manifestations, and surgical outcome of 97 patients with intracranial hydatid cysts, who received surgical treatment at the Neurosurgical Department of First Affiliated Hospital of Xinjiang Medical University from 1985 to 2010 and followed up the patient via sending a questionnaire or telephone contact. Clinical outcome was evaluated using the Karnofsky Performance Scale Index. Results: Headache and vomiting were the most common initial symptoms in our patients. Neurological deficits caused by the mass effect of the cysts were seen in 82 cases. On the X-ray, significant bone erosion was seen in only two cases with epidural hydatid cysts. Round-shaped and thin-walled homogeneous low-density cystic lesions without surrounding edema and enhancement were the main findings on computerized tomography (CT) in 95 patients with intraparenchymal hydatid cysts, while two cases with epidural hydatid cysts presented as a heterodensity lesions. On magnetic resonance imaging (MRI), hydatid cyst presented as a round-shaped low signal lesion in T1-weighted images and high signal lesion in T2-weighted images, without enhancement after contrast media injection, while the two cases with epidural cysts presented as mixed signal masses. Surgical removal of cyst was performed in all cases. Total removal was achieved in 93 cases without rupturing the cyst wall. Only two cysts ruptured during the dissection, resulting in two surgery-related mortalities. There was no other additional neurological deficit caused directly by surgery. In 97.2% of the patients, the Karnofsky Performance Scale score was 80 to 90 at the last follow-up. Conclusions Intracranial hydatid cyst is still a main cause of increased intracranial pressure among the patients in endemic areas for echinococcosis. CT and MRI are the best diagnostic Methods: and surgery is the treatment of choice for intracranial hydatid cysts.",
        "keywords": [
            "Intracranial hydatid cysts",
            "Surgery",
            "Treatment"
        ],
        "venue": "Chinese Medical Journal",
        "year": 2011,
        "id": "7CVU4TMN"
    },
    "4DO7DEuS": {
        "authors": [
            {
                "name": "Qi Hu",
                "org": "Ministry of Education Protein Science Laboratory, School of Life Sciences, Tsinghua University"
            },
            {
                "name": "Di Wu",
                "org": "Ministry of Education Protein Science Laboratory, School of Life Sciences, Tsinghua University"
            },
            {
                "name": "Wen Chen",
                "org": "Ministry of Education Protein Science Laboratory, School of Life Sciences, Tsinghua University"
            },
            {
                "name": "Zhen Yan",
                "org": "Ministry of Education Protein Science Laboratory, School of Life Sciences, Tsinghua University"
            },
            {
                "name": "Chuangye Yan",
                "org": "Ministry of Education Protein Science Laboratory, School of Life Sciences, Tsinghua University"
            },
            {
                "name": "Tianxi He",
                "org": "Department of Chemistry, Tsinghua University"
            },
            {
                "name": "Qionglin Liang",
                "org": "Department of Chemistry, Tsinghua University"
            },
            {
                "name": "Yigong Shi",
                "org": "Ministry of Education Protein Science Laboratory, School of Life Sciences, Tsinghua University"
            }
        ],
        "title": "Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome",
        "abstract": "Autocatalytic activation of an initiator caspase triggers the onset of apoptosis. In dying cells, caspase-9 activation is mediated by a multimeric adaptor complex known as the Apaf-1 apoptosome. The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that the previously reported 1:1 interaction between Apaf-1 caspase recruitment domain (CARD) and caspase-9 CARD is insufficient for the activation of caspase-9. Rather, formation of a multimeric CARD:CARD assembly between Apaf-1 and caspase-9, which requires three types of distinct interfaces, underlies caspase-9 activation. Importantly, an additional surface area on the multimeric CARD assembly is essential for caspase-9 activation. Together, these findings reveal mechanistic insights into the activation of caspase-9 by the Apaf-1 apoptosome and support the induced conformation model for initiator caspase activation by adaptor complexes.",
        "keywords": [
            "Apoptosis",
            "CARD",
            "Caspase activation",
            "Induced proximity",
            "Mechanism"
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2014,
        "id": "4DO7DEuS"
    },
    "l6cAVOmd": {
        "authors": [
            {
                "name": "Jianghui Zhu",
                "org": "Key Laboratory for Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Yeru Wang",
                "org": "Key Laboratory for Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Xiaoyu Song",
                "org": "Key Laboratory for Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Shenghui Cui",
                "org": "National Institutes for Food and Drug Control"
            },
            {
                "name": "Haibin Xu",
                "org": "Key Laboratory for Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Baowei Yang",
                "org": "College of Food Science and Engineering, Northwest A and F University"
            },
            {
                "name": "Jinlin Huang",
                "org": "Yangzhou University"
            },
            {
                "name": "Guihua Liu",
                "org": "Center for Disease Control and Prevention of Jilin Province"
            },
            {
                "name": "Qian Chen",
                "org": "Beijing Center for Disease Control and Prevention"
            },
            {
                "name": "Gang Zhou",
                "org": "Inner Mongolia Autonomous Institute for Food and Drug Inspection, Huhehaote, Inner Mongolia Autonomous"
            },
            {
                "name": "Qiuxia Chen",
                "org": "Center for Disease Control and Prevention of Guangdong Province"
            },
            {
                "name": "Fengqin Li",
                "org": "Key Laboratory for Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment"
            }
        ],
        "title": "Prevalence and quantification of Salmonella contamination in raw chicken carcasses at the retail in China",
        "abstract": "The quantitative contamination load of Salmonella in raw chicken carcasses at the retail level in six provinces and cities of China was determined within 1595 carcasses over 12 consecutive months. The overall Salmonella contamination rate was 41.6% and the median load of those contaminated was 4.6MPN/100g with 1.8MPN/100g as the 25th percentile and 18.0MPN/100g as the 75th percentile. There were significant variations in prevalence among carcasses sampled either in different provinces or sampling months. Carcasses collected in August had not only the highest prevalence of contamination (55.8%), but also the highest median (14.0MPN/100g) and 75th percentile load (120.0MPN/100g) values compared to January with lowest prevalence (26.5%), median (1.5MPN/100g) and 75th percentile load (7.6MPN/100g). The chilled (55.1%) stored carcasses was significantly higher in prevalence than those frozen (33.5%) and those freshly slaughtered (28.3%), those unpackaged (45.1%) was more likely to be contaminated with Salmonella than those packaged (37.4%). The present study revealed the widely prevalent Salmonella contamination among retail carcasses, indicating a strong potential of the cross-contamination occurred before and/or at the retail level. The study also provided quantitative data for a risk assessment evaluating potential intervention methods to reduce the risk of salmonellosis by consuming chicken meat of Chinese origin. \u00a9 2014 Elsevier Ltd.",
        "keywords": [
            "Chicken carcass",
            "China",
            "Quantitative determination",
            "Salmonella"
        ],
        "venue": "Food Control",
        "year": 2014,
        "id": "l6cAVOmd"
    },
    "nWJBCYHl": {
        "authors": [
            {
                "name": "Ye Ru Wang",
                "org": "Key Laboratory of Food Safety Risk Assessment"
            },
            {
                "name": "Qian Chen",
                "org": "Beijing Municipal Centre for Disease Control and Prevention"
            },
            {
                "name": "Sheng Hui Cui",
                "org": "National Institute for Food and Drug Control"
            },
            {
                "name": "Feng Qin Li",
                "org": "Key Laboratory of Food Safety Risk Assessment"
            }
        ],
        "title": "Characterization of staphylococcus aureus isolated from clinical specimens by matrix assisted laser desorption/ionization time-of-flight mass spectrometry",
        "abstract": "Objective To develop a matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) approach to identify Staphylococcus aureus (S. aureus) and differentiate methicillin-resistant S. aureus (MRSA) from methicillin-sensitive S. aureus (MSSA). Methods A total of 100 S. aureus strains isolated from clinical specimens and farm workers were collected and analyzed by MALDI-TOF-MS. And data obtained were interpreted with biotyper software. Results Ninety-two strains were identi?ed by MALDI-TOF-MS as S. aureus at a level of secure genus and probable species, and 4 strains were identified at probable genus after their cultivation, spectral collection and data preprocessing. One strain was identified as S. aureus with lower score. It was revealed that identification of S. aureus by MALDI-TOF-MS was highly correlated with typing by biochemical and serological methods with an accuracy as high as 97%. The biotyper cluster analysis showed that 100 isolates were divided into 2 types at the distance level of 400. Higher peak intensity in the mass of both 3784 Da and 5700 Da was observed in MRSA, whereas that was absent from MSSA. Conclusion MALDI-TOF-MS is considered as a simple, rapid and highly reproducible technique with high-throughput and accuracy for the identification of S. aureus and it can reliably differentiate MRSA from MSSA. \u00a9 2013 The Editorial Board of Biomedical and Environmental Sciences.",
        "keywords": [
            "Characterization",
            "MALDI-TOF-MS",
            "MRSA",
            "MSSA",
            "Staphylococcus aureus"
        ],
        "venue": "Biomedical and Environmental Sciences",
        "year": 2013,
        "id": "nWJBCYHl"
    },
    "UleoQLXj": {
        "authors": [
            {
                "name": "Yu-Guang Li",
                "org": "Department of Chemistry"
            },
            {
                "name": "Jie Ma",
                "org": "Department of Chemistry"
            },
            {
                "name": "Qian-Qian Zhang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Chang-Shui Wang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Qian Chen",
                "org": "Beijing Center for Disease Prevention and Control"
            }
        ],
        "title": "Sulfur-selective desulfurization of dibenzothiophene and diesel oil by newly isolated Rhodococcus erythropolis NCC-1",
        "abstract": "A dibenzothiophene (DBT)-desulfurizing bacteria strain was isolated from oil-contaminated soils and identified as Rhodococcus erythropolis NCC-1. Strain NCC-1 was found to convert DBT to hydroxybiphenyl (2-HBP) via the 4S pathway and also be able to use organic sulfur compounds other than DBT as a sole sulfur source. The strain could desulfurize 4,6-dimethyldibenzothiophene (4,6-DMDBT), which is one of the most recalcitrant dibenzothiophene derivatives to hydrodesulfurization. When two type of oils, a model oil [n-hexadecane (n-C16) containing DBT] and a hydrodesulfurized diesel oil with various organic sulfur compounds, were treated with Rhodococcus erythropolis NCC-1 cells, the total sulfur content significantly decreased, from 150 to 20 mg/L for n-C16 and from 554 to 274 mg/L for diesel oil. The newly isolated strain NCC-1 is considered to have good potential for application in the biodesulfurization of fossil fuels. \u00a9 2007 SIOC, CAS, & Wiley-VCH Verlag GmbH & Co. KGaA.",
        "keywords": [
            "Biodesulfurization",
            "Dibenzothiophene",
            "Diesel oil",
            "Rhodococcus erythropolis"
        ],
        "venue": "Chinese Journal of Chemistry",
        "year": 2007,
        "id": "UleoQLXj"
    },
    "JvNnqwXt": {
        "authors": [
            {
                "name": "Yeru Wang",
                "org": "National Institutes for Food and Drug Control"
            },
            {
                "name": "Qian Chen",
                "org": "Beijing Municipal Center for Disease Prevention and Control"
            },
            {
                "name": "Shenghui Cui",
                "org": "National Institutes for Food and Drug Control"
            },
            {
                "name": "Xiao Xu",
                "org": "National Institutes for Food and Drug Control"
            },
            {
                "name": "Jianghui Zhu",
                "org": "Key Laboratory of Food Safety Risk Assessment"
            },
            {
                "name": "Haipeng Luo",
                "org": "National Institutes for Food and Drug Control"
            },
            {
                "name": "Di Wang",
                "org": "Beijing Municipal Center for Disease Prevention and Control"
            },
            {
                "name": "Fengqin Li",
                "org": "Key Laboratory of Food Safety Risk Assessment"
            }
        ],
        "title": "Enumeration and characterization of salmonella isolates from retail chicken carcasses in Beijing, China",
        "abstract": "Epidemiological reports have implicated contaminated raw or undercooked chicken as primary vehicles of Salmonella transmission to human beings. Risk assessments relating to Salmonella contamination of poultry products in China are frequently hampered by the lack of quantitative data. In this study, whole chicken carcasses (n=395) were collected from the retail markets of Beijing, and the level of Salmonella contamination was enumerated by most probable number (MPN) analysis and all Salmonella isolates were further characterized for their serotypes and antimicrobial resistance. Overall, 49.9% (197/395) of the retail whole chicken carcasses were contaminated by Salmonella and the MPN values ranged from 1.5 to >550 MPN/100 g. The 50% percentile of Salmonella MPN value was 7.5 MPN/100 g in chicken carcass. The predominant serotypes isolated were Salmonella Enteritidis (n=309, 94 samples), Salmonella Indiana (n=205, 54 samples) and Salmonella Infantis (n=89, 23 samples). Multidrug-resistant Salmonella isolates were recovered from 100 chicken carcass samples; 102 isolates (from 41 chicken carcasses) even showed resistance to both ciprofloxacin and cefotaxime. Our findings showed a high prevalence of Salmonella contamination in retail chicken carcasses, which could be a source of exposure for consumers to multidrug-resistant isolates. This study provided baseline enumeration data for the risk assessment and evaluation of new control measures of Salmonella contamination in retail chicken products. \u00a9 Mary Ann Liebert, Inc.",
        "keywords": [
            ""
        ],
        "venue": "Foodborne Pathogens and Disease",
        "year": 2014,
        "id": "JvNnqwXt"
    },
    "1K5Lylb9": {
        "authors": [
            {
                "name": "Xiao Xu",
                "org": "Department of Food Science"
            },
            {
                "name": "Shenghui Cui",
                "org": "Department of Food Science"
            },
            {
                "name": "Fenglan Zhang",
                "org": "Department of Food Science"
            },
            {
                "name": "Yanping Luo",
                "org": "Department of Microbiology"
            },
            {
                "name": "Yihai Gu",
                "org": "3201 Hospital"
            },
            {
                "name": "Baowei Yang",
                "org": "College of Food Science"
            },
            {
                "name": "Fengqin Li",
                "org": "China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Qian Chen",
                "org": "Beijing Center for Disease Control and Prevention"
            },
            {
                "name": "Gang Zhou",
                "org": "Institute for Food and Drug Control"
            },
            {
                "name": "Yeru Wang",
                "org": "China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Lu Pang",
                "org": "China National Center for Food Safety Risk Assessment"
            },
            {
                "name": "Lan Lin",
                "org": "Department of Food Science"
            }
        ],
        "title": "Prevalence and characterization of cefotaxime and ciprofloxacin co-resistant escherichia coli isolates in retail chicken carcasses and ground pork, China",
        "abstract": "Retail meat products could serve as an important medium for the transfer of multidrug resistant isolates from food-producing animals to the community. In this study, the prevalence and characteristics of cefotaxime and ciprofloxacin co-resistant Escherichia coli isolates were investigated in retail chicken and ground pork samples from four provinces of China. The isolates were subjected to phylogenetic group typing and antimicrobial susceptibility testing. All isolates were further characterized by pulsed-field gel electrophoresis to determine the genetic relatedness. These isolates were also screened for beta-lactamase genes, quinolone resistance determinants by PCR, and followed by DNA sequence analysis. Cefotaxime and ciprofloxacin co-resistant E. coli isolates with diverse genetic origins were recovered in 31.9% (106/332) of retail meat samples. E. coli isolates of phylogenetic group A were dominant (59.4%, 63/106), and all isolates showed multidrug resistant profiles. The dominant resistant profiles were AMP-CAZ-CTX-CIP-CHL-GEN-SXT-TET (n=43) and AMP-CAZ-CTX-CIP-CHL-SXT-TET (n=43). Point mutations in quinolone resistance determination regions of topoisomerases were identified in all the isolates, and most of the isolates accumulated three (n=78) or four (n=21) point mutations. Plasmid-mediated quinolone-resistant determinants were identified in 68 isolates, including oqxAB (n=66), qnrS1 (n=7), qnrS2 (n=4), and aac(6\u2032)-Ib-cr (n=9). Eight subtypes of bla",
        "keywords": [
            ""
        ],
        "venue": "Microbial Drug Resistance",
        "year": 2014,
        "id": "1K5Lylb9"
    },
    "tpWwsxDx": {
        "id": "tpWwsxDx",
        "title": "Homeobox D10, a tumor suppressor, inhibits the proliferation and migration of esophageal squamous cell carcinoma.",
        "abstract": "Esophageal squamous cell carcinoma (ESCC) is one of the most common types of esophageal cancer, which is the sixth leading cause of cancer death globally. Homeobox D10 (HOXD10) is a member of the homeobox (HOX) gene family and has been reported to act as a tumor suppressor. However, the potential role of HOXD10 in ESCC has not been reported. Thus, the aim of this study was to examine the expression and function of HOXD10 in ESCC. The expressions of HOXD10 in human ESCC tissues and cell lines were detected by quantitative reverse transcription polymerase chain reaction and Western blot. The HOXD10 overexpressing cell lines were established, then CCK-8 and Transwell assays were performed to examine cell proliferation, migration, and invasion, respectively. The expression of EMT-related proteins and signaling pathway-related proteins were detected by Western blot. Our results showed that HOXD10 is lowly expressed in ESCC tissues as well as in ESCC cell lines. Ectopic overexpression of HOXD10 inhibited cell proliferation, migration, and invasion of ESCC cells (P\u2009<\u20090.05). HOXD10 overexpression repressed the epithelial-mesenchymal transition (EMT) process in ESCC cells. Besides, HOXD10 overexpression suppressed the activation of PI3K/AKT/mTOR signaling pathway. PI3K/Akt agonist, insulin-like growth factor-1, reversed the inhibitory effects of HOXD10 on cell proliferation and migration in ESCC cells. Additional in vivo study proved that ectopic expression of HOXD10 caused an obvious inhibitory effect on the tumor growth. These findings indicated that overexpression of HOXD10 suppressed the proliferation, migration, and invasion via regulating the PI3K/AKT/mTOR signaling pathway in ESCC cells. Thus, targeting HOXD10 may be considered as a therapeutic strategy for ESCC treatment.",
        "keywords": [
            "Homeobox D10 (HOXD10)",
            "PI3K/AKT/mTOR signaling pathway",
            "epithelial-mesenchymal transition (EMT)",
            "esophageal squamous cell carcinoma (ESCC)",
            "invasion",
            "migration"
        ],
        "authors": [
            {
                "name": "Jin Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China."
            },
            {
                "name": "Shiyuan Liu",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China."
            },
            {
                "name": "Danjie Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China."
            },
            {
                "name": "Zhenchuan Ma",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China."
            },
            {
                "name": "Liangzhang Sun",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China."
            }
        ],
        "venue": "Journal of cellular biochemistry",
        "year": 2019
    },
    "66MoKnu8": {
        "id": "66MoKnu8",
        "title": "Expression of urokinase-type plasminogen activator (uPA) and vascular endothelial growth factor (VEGF) in esophageal cancer and their influence to tumor angiogenesis",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jiantao Jiang",
                "org": ""
            },
            {
                "name": "Bin Zhou",
                "org": ""
            },
            {
                "name": "Shun-qun Zhang",
                "org": ""
            },
            {
                "name": "Shao-min Li",
                "org": ""
            },
            {
                "name": "Wei Zhang",
                "org": ""
            },
            {
                "name": "Jin Zhang",
                "org": ""
            },
            {
                "name": "Zhe Qiao",
                "org": ""
            },
            {
                "name": "Ranran Kong",
                "org": ""
            },
            {
                "name": "Yue-feng Ma",
                "org": ""
            }
        ],
        "venue": "Cancer Research and Clinic",
        "year": 2011
    },
    "xHl8rd2v": {
        "id": "xHl8rd2v",
        "title": "Effect of amiloride on the invasion capacity of esophageal carcinoma EC9706 cell line and its possible mechanisms",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jiantao Jiang",
                "org": ""
            },
            {
                "name": "Bin Zhou",
                "org": ""
            },
            {
                "name": "Shu-qun Zhang",
                "org": ""
            },
            {
                "name": "Shao-min Li",
                "org": ""
            },
            {
                "name": "Wei Zhang",
                "org": ""
            },
            {
                "name": "Jin Zhang",
                "org": ""
            },
            {
                "name": "Zhe Qiao",
                "org": ""
            },
            {
                "name": "Ranran Kong",
                "org": ""
            },
            {
                "name": "Yue-feng Ma",
                "org": ""
            }
        ],
        "venue": "Cancer Research and Clinic",
        "year": 2011
    },
    "ktxYrQet": {
        "id": "ktxYrQet",
        "title": "Silencing of Rab3D suppresses the proliferation and invasion of esophageal squamous cell carcinoma cells.",
        "abstract": "Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer. However, little is known about the role of Rab3D in carcinogenesis and progression of esophageal squamous cell carcinoma (ESCC). Thus, in this study, we investigated the expression patterns and functional roles of Rab3D in human ESCC. We demonstrated that Rab3D was highly expressed in human ESCC cell lines. In addition, knockdown of Rab3D significantly inhibited the proliferation of ESCC cells and reduced the tumorigenesis in vivo. Moreover, knockdown of Rab3D significantly suppressed ESCC cell migration/invasion and accordingly alerted EMT related markers, which including up-regulated E-cadherin and down-regulated N-cadherin in ESCC cells. Finally, knockdown of Rab3D inhibited the levels of p-PI3K and p-Akt in ECA-109 cells. In conclusion, our data demonstrated that Rab3D functions as an oncogene in ESCC and knockdown of Rab3D suppressed ESCC cell proliferation and invasion, potentially through the PI3K/Akt signaling pathway. Overall, these findings suggest that targeting the Rab3D may be a potential therapeutic target for treatment of ESCC.",
        "keywords": [
            "Esophageal squamous cell carcinoma (ESCC)",
            "Invasion",
            "Proliferation",
            "Rab3D"
        ],
        "authors": [
            {
                "name": "Jin Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China. Electronic address: jinzhangxa@126.com."
            },
            {
                "name": "Ranran Kong",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China."
            },
            {
                "name": "Liangzhang Sun",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
        "year": 2017
    },
    "4hxAh5ZS": {
        "id": "4hxAh5ZS",
        "title": "Efficient perovskite solar cells by metal ion doping",
        "abstract": "Realizing the theoretical limiting power conversion efficiency (PCE) in perovskite solar cells requires a better understanding and control over the fundamental loss processes occurring in the bulk of the perovskite layer and at the internal semiconductor interfaces in devices. One of the main challenges is to eliminate the presence of charge recombination centres throughout the film which have been observed to be most densely located at regions near the grain boundaries. Here, we introduce aluminium acetylacetonate to the perovskite precursor solution, which improves the crystal quality by reducing the microstrain in the polycrystalline film. At the same time, we achieve a reduction in the non-radiative recombination rate, a remarkable improvement in the photoluminescence quantum efficiency (PLQE) and a reduction in the electronic disorder deduced from an Urbach energy of only 12.6 meV in complete devices. As a result, we demonstrate a PCE of 19.1% with negligible hysteresis in planar heterojunction solar cells comprising all organic p and n-type charge collection layers. Our work shows that an additional level of control of perovskite thin film quality is possible via impurity cation doping, and further demonstrates the continuing importance of improving the electronic quality of the perovskite absorber and the nature of the heterojunctions to further improve the solar cell performance.",
        "keywords": "",
        "authors": [
            {
                "name": "Jacob Tse-Wei Wang",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Zhiping Wang",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Sandeep Pathak",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Wei Zhang",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Dane W. deQuilettes",
                "org": "Department of Chemistry, University of Washington, Box 351700,Seattle,USA"
            },
            {
                "name": "Florencia Wisnivesky-Rocca-Rivarola",
                "org": "Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road,Cambridge CB3 0FS,UK"
            },
            {
                "name": "Jian Huang",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Pabitra K. Nayak",
                "org": ""
            },
            {
                "name": "Jay B. Patel",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Hanis A. Mohd Yusof",
                "org": "Department of Materials, University of Oxford, Parks Road,Oxford,UK"
            },
            {
                "name": "Yana Vaynzof",
                "org": "Kirchhoff Institute for Physics (KIP), Im Neuenheimer Feld 227,69120 Heidelberg,Germany"
            },
            {
                "name": "Rui Zhu",
                "org": "State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University,Beijing,China"
            },
            {
                "name": "Ivan Ramirez",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Jin Zhang",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Caterina Ducati",
                "org": "Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road,Cambridge CB3 0FS,UK"
            },
            {
                "name": "C.R.M. Grovenor",
                "org": "Department of Materials, University of Oxford, Parks Road,Oxford,UK"
            },
            {
                "name": "Michael B. Johnston",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "David S. Ginger",
                "org": "Department of Chemistry, University of Washington, Box 351700,Seattle,USA"
            },
            {
                "name": "R. J. Nicholas",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            },
            {
                "name": "Henry J. Snaith",
                "org": "Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road,Oxford OX1 3PU,UK"
            }
        ],
        "venue": "Energy and Environmental Science",
        "year": 2016
    },
    "AKDWDDZe": {
        "id": "AKDWDDZe",
        "title": "Knockdown of Ubiquitin-Specific Protease 14 (USP14) Inhibits the Proliferation and Tumorigenesis in Esophageal Squamous Cell Carcinoma Cells.",
        "abstract": "Ubiquitin-specific protease 14 (USP14), one of three proteasome-associated deubiquitinating enzymes (DUBs), plays an essential role in the development of human carcinoma. However, to the best of our knowledge, the role of USP14 in esophageal squamous cell carcinoma (ESCC) is unknown. In the current study, we investigated the expression and role of USP14 in ESCC. Our results showed that the level of USP14 was significantly increased in ESCC tissues and cell lines. Downregulation of USP14 significantly inhibited ESCC cell proliferation and ESCC tumor growth in nude mice. Downregulation of USP14 also suppressed the migration/invasion in ESCC cells. Mechanically, downregulation of USP14 decreased the protein expression levels of \u03b2-catenin, cyclin D1, and c-Myc in ESCC cells. In conclusion, our study shows that USP14 plays an important role in the progression and metastasis of ESCC. Therefore, these data suggest that USP14 may be a potentially useful therapeutic strategy for the treatment of ESCC.",
        "keywords": "",
        "authors": [
            {
                "name": "Jin Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China."
            },
            {
                "name": "Danjie Zhang",
                "org": ""
            },
            {
                "name": "Liangzhang Sun",
                "org": ""
            }
        ],
        "venue": "Oncology research",
        "year": 2017
    },
    "5JoZoHCx": {
        "id": "5JoZoHCx",
        "title": "Silencing of Rab3D suppresses the proliferation and invasion of esophageal squamous cell carcinoma cells.",
        "abstract": "Rab3D is a member of the ras-related GTP-binding protein Rab family and was found up-regulated in several types of cancer. However, little is known about the role of Rab3D in carcinogenesis and progression of esophageal squamous cell carcinoma (ESCC). Thus, in this study, we investigated the expression patterns and functional roles of Rab3D in human ESCC. We demonstrated that Rab3D was highly expressed in human ESCC cell lines. In addition, knockdown of Rab3D significantly inhibited the proliferation of ESCC cells and reduced the tumorigenesis in vivo. Moreover, knockdown of Rab3D significantly suppressed ESCC cell migration/invasion and accordingly alerted EMT related markers, which including up-regulated E-cadherin and down-regulated N-cadherin in ESCC cells. Finally, knockdown of Rab3D inhibited the levels of p-PI3K and p-Akt in ECA-109 cells. In conclusion, our data demonstrated that Rab3D functions as an oncogene in ESCC and knockdown of Rab3D suppressed ESCC cell proliferation and invasion, potentially through the PI3K/Akt signaling pathway. Overall, these findings suggest that targeting the Rab3D may be a potential therapeutic target for treatment of ESCC.",
        "keywords": [
            "Esophageal squamous cell carcinoma (ESCC)",
            "Invasion",
            "Proliferation",
            "Rab3D"
        ],
        "authors": [
            {
                "name": "Jin Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China. Electronic address: jinzhangxa@126.com."
            },
            {
                "name": "Ranran Kong",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China."
            },
            {
                "name": "Liangzhang Sun",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
        "year": 2017
    },
    "vuom9HrW": {
        "id": "vuom9HrW",
        "title": "Knockdown of DDX5 Inhibits the Proliferation and Tumorigenesis in Esophageal Cancer.",
        "abstract": "DEAD (Asp-Glu-Ala-Asp) box protein 5 (DDX5), a prototypical member of the DEAD/H-box protein family, has been involved in several human malignancies. However, the expression and biological role of DDX5 in esophageal cancer (EC) remain largely unknown. In this study, we examined the role of DDX5 in regulating EC cell proliferation and tumorigenesis and explored its possible molecular mechanism. We found that DDX5 was overexpressed in human EC cell lines. In addition, knockdown of DDX5 significantly inhibited the proliferation of EC cells in vitro and the growth of EC xenografts in vivo. Knockdown of DDX5 also suppressed the migration/invasion and epithelial-to-mesenchymal transition (EMT) phenotype in EC cells. Furthermore, we observed that knockdown of DDX5 inhibited the expression of \u03b2-catenin, c-Myc, and cyclin D1 in EC cells. In conclusion, our findings provide the first evidence that siRNA-DDX5 inhibited the proliferation and invasion of EC cells through suppressing the Wnt/\u03b2-catenin signaling pathway. Therefore, DDX5 may be a novel potential therapeutic target for the prevention and treatment of EC.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhenchuan Ma",
                "org": ""
            },
            {
                "name": "Jie Feng",
                "org": ""
            },
            {
                "name": "Yurui Guo",
                "org": ""
            },
            {
                "name": "Ranran Kong",
                "org": ""
            },
            {
                "name": "Yuefeng Ma",
                "org": ""
            },
            {
                "name": "Liangzhang Sun",
                "org": ""
            },
            {
                "name": "Xiaoping Yang",
                "org": ""
            },
            {
                "name": "Bin Zhou",
                "org": ""
            },
            {
                "name": "Shaomin Li",
                "org": ""
            },
            {
                "name": "Wei Zhang",
                "org": ""
            },
            {
                "name": "Jiantao Jiang",
                "org": ""
            },
            {
                "name": "Jin Zhang",
                "org": ""
            },
            {
                "name": "Zhe Qiao",
                "org": ""
            },
            {
                "name": "Yao Cheng",
                "org": ""
            },
            {
                "name": "Danjie Zha",
                "org": ""
            },
            {
                "name": "Shiyuan Liu",
                "org": ""
            }
        ],
        "venue": "Oncology research",
        "year": 2017
    },
    "2Y8x9Y4D": {
        "id": "2Y8x9Y4D",
        "title": "PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma",
        "abstract": "AIM To evaluate PIK3CA gene mutational status in Northwest Chinese esophageal squamous cell carcinoma (ESCC) patients, and examine the associations of PIK3CA gene mutations with clinicopathological characteristics and clinical outcome. METHODS A total of 210 patients with ESCC who underwent curative resection were enrolled in this study. Pyrosequencing was applied to investigate mutations in exons 9 and 20 of PIK3CA gene in 210 Northwest Chinese ESCCs. The associations of PIK3CA gene mutations with clinicopathological characteristics and clinical outcome were examined. RESULTS PIK3CA gene mutations in exon 9 were detected in 48 cases (22.9%) of a non-biased database of 210 curatively resected Northwest Chinese ESCCs. PIK3CA gene mutations were not associated with sex, tobacco use, alcohol use, tumor location, stage, or local recurrence. When compared with wild-type PIK3CA gene cases, patients with PIK3CA gene mutations in exons 9 experienced significantly better disease-free survival and overall survival rates. CONCLUSION The results of this study suggest that PIK3CA gene mutations could act as a prognostic biomarker in Northwest Chinese ESCC patients.",
        "keywords": "",
        "authors": [
            {
                "name": "Shiyuan Liu",
                "org": ""
            },
            {
                "name": "Wei Chen",
                "org": ""
            },
            {
                "name": "Ehtesham Annait Chughtai",
                "org": ""
            },
            {
                "name": "Zhe Qiao",
                "org": ""
            },
            {
                "name": "Jiantao Jiang",
                "org": ""
            },
            {
                "name": "Shaomin Li",
                "org": ""
            },
            {
                "name": "Wei Zhang",
                "org": ""
            },
            {
                "name": "Jin Zhang",
                "org": ""
            }
        ],
        "venue": "World Journal of Gastroenterology",
        "year": 2017
    },
    "8Hfu1ibF": {
        "id": "8Hfu1ibF",
        "title": "p38 predicts depression and poor outcome in esophageal cancer.",
        "abstract": "p38 mitogen-activated protein kinase (MAPK) signaling has been implicated in the cancer development and progression. However, the precise mechanism of this association remains unknown. The aim of the present study was to evaluate the association between p38 and cancer progression, including investigations into the effects on cell proliferation, resistance to thalidomide, indoleamine 2,3-dioxygenase (IDO) expression and prognosis in patients with esophageal cancer. The present retrospective study included patients with stage I-III esophageal cancer. A total of 228 patients with esophageal cancer were recruited to analyze the expression of phosphorylated (p)-p38 and IDO in tumor, and normal tissues through immunohistochemistry. Depression status was measured using the Zung Self-Rating Depression Scale. P38 cDNA was transfected into esophageal cancer cells to assess tumor cell viability, sensitivity to thalidomide treatment and IDO gene expression. Western blotting and flow cytometry was used to analyze protein expression alterations, and apoptosis in esophageal cancer cells. P-p38 protein was expressed in 68.9% of cancer tissues, and was significantly associated with depressive symptoms, tumor recurrence and poor survival of patients.  experiments revealed that the expression of p-p38 induced esophageal cancer Eca-109 and TE-1 cell viability, and resistance to thalidomide treatment, as well as in the expression of IDO without the application of lipopolysaccharides. Further follow-up of patients revealed that depression was also an independent factor for early recurrence and overall survival rate. Altered p38 MAPK expression was associated with poor outcome in patients with esophageal cancer. p38 may be a potential biomarker for the prediction of depressive symptoms and prognosis in patients with esophageal cancer.",
        "keywords": [
            "depression",
            "esophageal cancer",
            "p38"
        ],
        "authors": [
            {
                "name": "Yao Cheng",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Zhe Qiao",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Chengxue Dang",
                "org": "Department of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China."
            },
            {
                "name": "Bin Zhou",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Shaomin Li",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Wei Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Jiantao Jiang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Yongchun Song",
                "org": "Department of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China."
            },
            {
                "name": "Jin Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China."
            },
            {
                "name": "Dongmei Diao",
                "org": "Department of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China."
            }
        ],
        "venue": "Oncology letters",
        "year": 2017
    },
    "3HR3m8FU": {
        "id": "3HR3m8FU",
        "title": "The crucial role of miR-126 on suppressing progression of esophageal cancer by targeting VEGF-A.",
        "abstract": "We believe that restoring miR-126 levels may be a promising therapeutic approach in cases of esophageal cancer.",
        "keywords": [
            "Cell proliferation",
            "Esophageal cancer",
            "Lentivirus package",
            "MTT assay",
            "Tumorgenesis",
            "VEGF-A",
            "Xenograft model",
            "miR-126"
        ],
        "authors": [
            {
                "name": "Ranran Kong",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Yuefeng Ma",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Jie Feng",
                "org": "Department of Nephrology, The First Affiliated Hospital, Xi'an Jiaotong University, 710061 Xi'an, Shaanxi China."
            },
            {
                "name": "Shaomin Li",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Wei Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Jiantao Jiang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Jin Zhang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Zhe Qiao",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Xiaoping Yang",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            },
            {
                "name": "Bin Zhou",
                "org": "Department of Thoracic Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, 710004 Xi'an, Shaanxi China."
            }
        ],
        "venue": "Cellular & molecular biology letters",
        "year": 2016
    },
    "7sqVe64F": {
        "id": "7sqVe64F",
        "title": "PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma.",
        "abstract": "The results of this study suggest that  gene mutations could act as a prognostic biomarker in Northwest Chinese ESCC patients.",
        "keywords": [
            "Esophageal squamous cell carcinoma",
            "Northwest Chinese",
            "PIK3CA gene mutations",
            "Prognostic significance"
        ],
        "authors": [
            {
                "name": "Shi-Yuan Liu",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Wei Chen",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Ehtesham Annait Chughtai",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Zhe Qiao",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Jian-Tao Jiang",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Shao-Min Li",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Wei Zhang",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            },
            {
                "name": "Jin Zhang",
                "org": "Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China."
            }
        ],
        "venue": "World journal of gastroenterology",
        "year": 2017
    },
    "l4Pb5CaO": {
        "authors": [
            {
                "name": "Jin He",
                "org": "Key Laboratory of Integrated Microsystems"
            },
            {
                "name": "Lining Zhang",
                "org": "TSRC"
            },
            {
                "name": "Rui Zheng",
                "org": "TSRC"
            },
            {
                "name": "Jian Zhang",
                "org": "TSRC"
            },
            {
                "name": "Mansun Chan",
                "org": "Department of Electronics and Computer Engineering"
            }
        ],
        "title": "A continuous surface-potential solution from accumulation to inversion for intrinsic symmetric double-gate MOSFETs",
        "abstract": "A continuous surface-potential solution of Poisson's equation is derived for intrinsic (or lightly doped) symmetric double-gate (DG) Metal-Oxide- Semiconductor-Field-Effect-Transistors (MOSFETs). The resulting expression is smooth and continuous from accumulation through depletion to inversion regions. The dependences of the surface potential on various physical parameters including the quasi-Fermi potential, silicon film thickness, gate dielectric thickness and temperature are studied and compared with 2-D numerical simulation. Excellent agreements between them suggest that the proposed surface-potential solution is accurate over a wide range of physical parameters and can be used in surface-potential-based symmetric DG MOSFET modelling.",
        "keywords": [
            "Compact modelling",
            "Device physics",
            "DG-MOSFETs",
            "Non-classical CMOS",
            "Surface potential",
            "ULSI circuit simulation"
        ],
        "venue": "Molecular Simulation",
        "year": 2009,
        "id": "l4Pb5CaO"
    },
    "QzAgrUXU": {
        "authors": [
            {
                "name": "Hui Yu",
                "org": ""
            },
            {
                "name": "Jian Qiu",
                "org": ""
            }
        ],
        "title": "Protection planning of historical and cultural city based on the concept of disaster prevention and reduction",
        "abstract": "Wenchuan earthquake caused the heavy losses in relation to a number of valuable historical and cultural cities in the disaster areas. A comparison to the experiences concerning prevention and reduction planning systems applied in the advanced countries found that the lack of similar ideas before the earthquake contributed one of the main factors to the losses. A further review of the whole post-disaster reconstruction planning system and a field survey affirmed that the protection of the historical and cultural cities was specified in principle, but, in practice, the special protection planning was ignored and the protection endeavor was needed. Therefore, some objective suggestions and opinions regarding historical and cultural city planning and construction were inferred from the viewpoints of disaster prevention and reduction. \u00a9 (2011) Trans Tech Publications.",
        "keywords": [
            "Disaster prevention and reduction",
            "Historical and cultural city",
            "Protection planning",
            "Reconstruction",
            "Wenchuan earthquake"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2011,
        "id": "QzAgrUXU"
    },
    "t0JbJgk1": {
        "authors": [
            {
                "name": "Hui Yu",
                "org": "Faculty of Architecture"
            },
            {
                "name": "Hongcheng Deng",
                "org": "Faculty of Architecture"
            },
            {
                "name": "Zhenxiang Zhao",
                "org": "Construction Engineering Department"
            },
            {
                "name": "Yu Xiao",
                "org": "College of Environment and Civil Engineering"
            }
        ],
        "title": "Transformation of landscape planning and design in computer supported cooperative work era",
        "abstract": "From the point of design methodology, change quickly development computer technology of Computer Supported Cooperative Work (CSCW) has influence on the actions of Landscape planning and design, such as renovation of design tradition conception, new ways for shape originality, and testing method for landscape planning and design. It has practicality value of determining computer technology values in Landscape Architecture design and thinking. \u00a9 2008 IEEE.",
        "keywords": [
            "Computer technology",
            "Design methodology",
            "Landscape planning and design"
        ],
        "venue": "Proceedings of the 2008 12th International Conference on Computer Supported Cooperative Work in Design, CSCWD",
        "year": 2008,
        "id": "t0JbJgk1"
    },
    "jT7usEhH": {
        "id": "jT7usEhH",
        "title": "Preparation of Ag-modified Zn 2 GeO 4 nanorods for photo-degradation of organic pollutants",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guohua jiang",
                "org": ""
            },
            {
                "name": "bolin tang",
                "org": ""
            },
            {
                "name": "xia li",
                "org": ""
            },
            {
                "name": "zhen wei",
                "org": ""
            },
            {
                "name": "xiaohong wang",
                "org": ""
            },
            {
                "name": "wenxing chen",
                "org": ""
            },
            {
                "name": "junmin wan",
                "org": ""
            },
            {
                "name": "liang shen",
                "org": ""
            }
        ],
        "venue": "Powder Technology",
        "year": 2014
    },
    "DVpgJy6F": {
        "id": "DVpgJy6F",
        "title": "Immobilization of N, S-codoped BiOBr on glass fibers for photocatalytic degradation of rhodamine B",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guohua jiang",
                "org": ""
            },
            {
                "name": "xia li",
                "org": ""
            },
            {
                "name": "zhen wei",
                "org": ""
            },
            {
                "name": "xiaohong wang",
                "org": ""
            },
            {
                "name": "tengteng jiang",
                "org": ""
            },
            {
                "name": "xiangxiang du",
                "org": ""
            },
            {
                "name": "wenxing chen",
                "org": ""
            }
        ],
        "venue": "Powder Technology",
        "year": 2014
    },
    "syG4t1zk": {
        "id": "syG4t1zk",
        "title": "One-pot solvothermal preparation of S-doped BiOBr microspheres for efficient visible-light induced photocatalysis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wenxing chen",
                "org": ""
            },
            {
                "name": "xiaohong wang",
                "org": ""
            },
            {
                "name": "zhen wei",
                "org": ""
            },
            {
                "name": "liang shen",
                "org": ""
            },
            {
                "name": "guohua jiang",
                "org": ""
            },
            {
                "name": "xia li",
                "org": ""
            }
        ],
        "venue": "modeling and retrieval of context",
        "year": 2013
    },
    "IMZ8dufE": {
        "id": "IMZ8dufE",
        "title": "Preparation and drug release property of CO 2 stimulus-sensitive poly( N , N -dimethylaminoethyl methacrylate)- b -polystyrene nanoparticles",
        "abstract": "",
        "keywords": [
            "nanoparticles"
        ],
        "authors": [
            {
                "name": "xiaohong wang",
                "org": ""
            },
            {
                "name": "guohua jiang",
                "org": ""
            },
            {
                "name": "zhen wei",
                "org": ""
            },
            {
                "name": "xia li",
                "org": ""
            },
            {
                "name": "bolin tang",
                "org": ""
            }
        ],
        "venue": "European Polymer Journal",
        "year": 2013
    },
    "oUkB2Y6p": {
        "id": "oUkB2Y6p",
        "title": "Boronic acid functionalized N-doped carbon quantum dots as fluorescent probe for selective and sensitive glucose determination",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guohua jiang",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "tengteng jiang",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "xia li",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "zheng wei",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "xiangxiang du",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "xiaohong wang",
                "org": "zhejiang sci tech university"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "2GCW2Ntn": {
        "id": "2GCW2Ntn",
        "title": "Preparation of N-Doped Bi2WO6 Microspheres for Efficient Visible Light-Induced Photocatalysis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "bolin tang",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "guohua jiang",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "zhen wei",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "xia li",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "xiaohong wang",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "tengteng jiang",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "wenxing chen",
                "org": "zhejiang sci tech university"
            },
            {
                "name": "junmin wan",
                "org": "zhejiang sci tech university"
            }
        ],
        "venue": "Acta Metallurgica Sinica (english Letters)",
        "year": 2014
    },
    "CQ62xrHp": {
        "id": "CQ62xrHp",
        "title": "Growth of N-doped BiOBr nanosheets on carbon fibers for photocatalytic degradation of organic pollutants under visible light irradiation",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "guohua jiang",
                "org": ""
            },
            {
                "name": "xia li",
                "org": ""
            },
            {
                "name": "zhen wei",
                "org": ""
            },
            {
                "name": "tengteng jiang",
                "org": ""
            },
            {
                "name": "xiangxiang du",
                "org": ""
            },
            {
                "name": "wenxing chen",
                "org": ""
            }
        ],
        "venue": "Powder Technology",
        "year": 2014
    },
    "m4PwWSSL": {
        "id": "m4PwWSSL",
        "title": "Facile one-pot synthesis of fluorescent hyperbranched polymers for optical detection of glucose",
        "abstract": "",
        "keywords": [
            "fluorescent",
            "michael addition"
        ],
        "authors": [
            {
                "name": "tengteng jiang",
                "org": ""
            },
            {
                "name": "guohua jiang",
                "org": ""
            },
            {
                "name": "xiaohong wang",
                "org": ""
            },
            {
                "name": "yue dong",
                "org": ""
            },
            {
                "name": "zhen wei",
                "org": ""
            },
            {
                "name": "xia li",
                "org": ""
            },
            {
                "name": "bolin tang",
                "org": ""
            }
        ],
        "venue": "Designed Monomers and Polymers",
        "year": 2014
    },
    "HoLU18gi": {
        "authors": [
            {
                "name": "S. Han",
                "org": "First College of Clinical Medicine"
            },
            {
                "name": "W. Huang",
                "org": "First College of Clinical Medicine"
            },
            {
                "name": "Y. Liu",
                "org": "First College of Clinical Medicine"
            },
            {
                "name": "S. Pan",
                "org": "Department of Pathophysiology"
            },
            {
                "name": "Z. Feng",
                "org": "Department of Thoracic and Cardiovascular Surgery"
            },
            {
                "name": "S. Li",
                "org": "Department of Thoracic and Cardiovascular Surgery"
            }
        ],
        "title": "Does leukocyte-depleted blood cardioplegia reduce myocardial reperfusion injury in cardiac surgery? A systematic review and meta-analysis",
        "abstract": "Blood cardioplegia in cardiac surgery contains leukocytes, which causes the inflammatory reaction and promotes myocardial reperfusion injury. The removal of leukocytes from the cardioplegia line, using specialized filters, has been proposed as one of the effective methods in attenuating the inflammatory response. We performed a two-level search to identify randomized, controlled trials concerning the effects of leukocyte-depleted blood cardioplegia on myocardial reperfusion injury. Sixteen studies, comprising 738 patients, met the selection criteria. There are significant reductions in creatinine kinase isoenzyme MB (CK-MB) during 4-8h postoperatively (SMD - 0.577; 95% CI -0.795 to -0.358; p=0.000), CK-MB peak (SMD - 0.713; 95% CI -1.027 to -0.400; p=0.000), troponin in the period of 4-8h postoperatively (SMD - 0.502; 95% CI -0.935 to -0.069; p=0.023), troponin peak (SMD - 0.826; 95% CI -1.373 to -0.279; p=0.003) and inotropic support (RR, 0.500; 95% CI 0.269 to 0.931; p=0.029). Leukocyte-depleted blood cardioplegia may reduce myocardial reperfusion injury in the early postoperative period, but there has been no evidence to support the clinically significant difference. Larger and more precise randomized control trials are needed to further elucidate the cardioprotective effects of cardioplegia leukofiltration. \u00a9 The Author(s) 2013.",
        "keywords": [
            "cardiac surgery",
            "cardioplegia",
            "leukocytes",
            "myocardial injury",
            "reperfusion"
        ],
        "venue": "Perfusion (United Kingdom)",
        "year": 2013,
        "id": "HoLU18gi"
    },
    "E1qi3Xg6": {
        "authors": [
            {
                "name": "Yingguo Hu",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering, Ministry of Education, Wuhan University"
            },
            {
                "name": "Wenbo Lu",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering, Ministry of Education, Wuhan University"
            },
            {
                "name": "Ming Chen",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering, Ministry of Education, Wuhan University"
            },
            {
                "name": "Peng Yan",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering, Ministry of Education, Wuhan University"
            },
            {
                "name": "Liang Liu",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering, Ministry of Education, Wuhan University"
            }
        ],
        "title": "Implementation and verification of SPH-fem coupling blasting damage analytical method",
        "abstract": "Comprehensive numerical simulation of rock blasting is always a difficulty and a focus topic of blasting engineering. Based on the secondary development of LS-DYNA, smoothed particle hydrodynamics(SPH) method is implemented into the blasting damage method. Then, a method of SPH used in the near zone and FEM used in the far zone was realized. Dynamic effect of deep hole bench blasting was simulated with this method based on the Specific engineering example. Rock mass cracking and throwing reveals that SPH-FEM method could simulate the large deformation in the near zone. At the same time the comparison between blasting vibration monitoring and results demonstrate that SPH-FEM method could forecast the blasting vibration and dynamic response in far zone. Deformation and damage characteristics of different resistance line of deep hole bench blasting were compared. Research results can provide certain reference for numerical simulation of blasting and blasting crushing mechanism research.",
        "keywords": [
            "Coupling",
            "Damage",
            "Excavation",
            "Finite element method (FEM)",
            "Rock mechanics",
            "Smooth particle hydrodynamics(SPH)"
        ],
        "venue": "Yanshilixue Yu Gongcheng Xuebao/Chinese Journal of Rock Mechanics and Engineering",
        "year": 2015,
        "id": "E1qi3Xg6"
    },
    "xOsVUWbe": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering of Ministry of Education, Wuhan University"
            },
            {
                "name": "Ming Chen",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering of Ministry of Education, Wuhan University"
            },
            {
                "name": "Wenbo Lu",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering of Ministry of Education, Wuhan University"
            },
            {
                "name": "Yingguo Hu",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering of Ministry of Education, Wuhan University"
            },
            {
                "name": "Zhendong Leng",
                "org": "Key Laboratory of Rock Mechanics in Hydraulic Structural Engineering of Ministry of Education, Wuhan University"
            }
        ],
        "title": "Effect of the location of the detonation initiation point for bench blasting",
        "abstract": "Uneven floor and fragmentation play an important role in blasting operations due to the direct effects on the efficiency of hauling and loading. This paper focuses on the influences of initiation position on bench blasting in order to improve blasting effects. The numerical simulations of bench blasting at different initiation points (top, middle, and bottom) are implemented based on secondary development of LS-DYNA with a tensile-compressive damage model. The damage spatial distribution characteristics of different initiation points are compared. The outlines of rock foundation and boulder areas are analyzed with the damage threshold of critical breakage that is ascertained by acoustic characteristic of damage rock mass. Results of the numerical simulations demonstrate that different initiation points make a great influence on the stress and energy distribution in blasting process and induce different blasting effects. Middle initiation turns out to be the best initiation to increase the flatness of the floor and decrease the oversize boulder ratio simultaneously, which will increase the damage areas of the bottom and top regions and give a better blasting effect. Field experiment in Baihetan Station was carried out to validate conclusions of numerical simulation. Research could provide a good reference for the improvement of rock blasting.",
        "keywords": [
            ""
        ],
        "venue": "Shock and Vibration",
        "year": 2015,
        "id": "xOsVUWbe"
    },
    "ZkTYzZ2X": {
        "authors": [
            {
                "name": "Yue Liu",
                "org": ""
            },
            {
                "name": "Jia He",
                "org": ""
            },
            {
                "name": "Minjie Guo",
                "org": ""
            },
            {
                "name": "Qing Yang",
                "org": ""
            },
            {
                "name": "Xinsheng Zhang",
                "org": ""
            }
        ],
        "title": "An overview of big data industry in China [Guest editors' introduction]",
        "keywords": [
            "big data",
            "market analysis",
            "policy environment",
            "policy recommendation",
            "technological trend"
        ],
        "venue": "China Communications",
        "year": 2014,
        "id": "ZkTYzZ2X"
    },
    "1nggVot7": {
        "id": "1nggVot7",
        "title": "In vivo diagnosis of gastric cancer using raman endoscopy and ant colony optimization techniques",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Mads Sylvest Bergholt",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            },
            {
                "name": "Jimmy So Bok Yan",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "International Journal of Cancer",
        "year": 2010
    },
    "DGN42VgD": {
        "id": "DGN42VgD",
        "title": "Spectroscopic diagnosis of laryngeal carcinoma using near-infrared Raman spectroscopy and random recursive partitioning ensemble techniques",
        "abstract": "In this work, we evaluated the diagnostic ability of near-infrared (NIR) Raman spectroscopy associated with the ensemble recursive partitioning algorithm based on random forests for identifying cancer from normal tissue in the larynx. A rapid-acquisition NIR Raman system was utilized for tissue Raman measurements at 785 nm excitation, and 50 human laryngeal tissue specimens (20 normal; 30 malignant tumors) were used for NIR Raman studies. The random forests method was introduced to develop effective diagnostic algorithms for classification of Raman spectra of different laryngeal tissues. High- quality Raman spectra in the range of 800-1800 cm\ufffd 1 can be acquired from laryngeal tissue within 5 seconds. Raman spectra differed significantly between normal and malignant laryngeal tissues. Classification results obtained from the random forests algorithm on tissue Raman spectra yielded a diagnostic sensitivity of 88.0% and specificity of 91.4% for laryngeal malignancy identification. The random forests technique also provided variables importance that facilitates correlation of significant Raman spectral features with cancer transformation. This study shows that NIR Raman spectroscopy in conjunction with random forests algorithm has a great potential for the rapid diagnosis and detection of malignant tumors in the larynx.",
        "keywords": [],
        "authors": [
            {
                "name": "Teh Seng Khoon",
                "org": "Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576."
            },
            {
                "name": "Zheng Wei",
                "org": ""
            },
            {
                "name": "Lau David P",
                "org": ""
            },
            {
                "name": "Huang Zhiwei",
                "org": ""
            }
        ],
        "venue": "The Analyst",
        "year": 2009
    },
    "NXCSVOyR": {
        "id": "NXCSVOyR",
        "title": "Effect of hormonal variation on in vivo high wavenumber Raman spectra improves cervical precancer detection",
        "abstract": "",
        "keywords": [
            "near infrared",
            "fingerprint recognition",
            "principal component analysis",
            "water",
            "raman spectroscopy",
            "data analysis"
        ],
        "authors": [
            {
                "name": "shiyamala duraipandian",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "joseph ng",
                "org": "national university of singapore"
            },
            {
                "name": "jeffrey j h low",
                "org": "national university of singapore"
            },
            {
                "name": "a ilancheran",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2012
    },
    "VZTAj2KH": {
        "id": "VZTAj2KH",
        "title": "Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy",
        "abstract": "We assess the clinical utility of a unique simultaneous fingerprint (FP) (i.e., 800-1800 cm\u22121) and high-wavenumber (HW) (i.e., 2800-3600 cm\u22121) fiber-optic Raman spectroscopy for in vivo diagnosis of laryngeal cancer at endoscopy. A total of 2124 high-quality in vivo FP/HW Raman spectra (normal = 1321; cancer = 581) were acquired from 101 tissue sites (normal = 71; cancer = 30) of 60 patients (normal = 44; cancer = 16) undergoing routine endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous laryngeal tissue that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in the larynx. Partial least squares-discriminant analysis and leave-one tissue site-out, cross-validation were employed on the in vivo FP/HW tissue Raman spectra acquired, yielding a diagnostic accuracy of 91.1% (sensitivity: 93.3% (28/30); specificity: 90.1% (64/71)) for laryngeal cancer identification, which is superior to using either FP (accuracy: 86.1%; sensitivity: 86.7% (26/30); specificity: 85.9% (61/71)) or HW (accuracy: 84.2%; sensitivity: 76.7% (23/30); specificity: 87.3% (62/71)) Raman technique alone. Further receiver operating characteristic analysis reconfirms the best performance of the simultaneous FP/HW Raman technique for laryngeal cancer diagnosis. We demonstrate for the first time that the simultaneous FP/HW Raman spectroscopy technique can be used for improving real-time in vivo diagnosis of laryngeal carcinoma during endoscopic examination.",
        "keywords": "",
        "authors": [
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore"
            },
            {
                "name": "Chwee Ming Lim",
                "org": "Department of Otolaryngology, Head and Neck Surgery, National University of Singapore and National University Health System, 119074 Singapore"
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore"
            }
        ],
        "venue": "Biomedical Optics Express",
        "year": 2016
    },
    "mJUF5kLn": {
        "id": "mJUF5kLn",
        "title": "Image-guided near-infrared Raman spectroscopy for in vivo detection of gastric dysplasia",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "near infrared"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "seng khoon teh",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2009
    },
    "UJojMoct": {
        "id": "UJojMoct",
        "title": "Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo.",
        "abstract": "Direct visualization of microvasculature provides significant insights in microcirculation and critically impacts the diagnosis and treatment of microcirculatory diseases. Recently, we discovered that the high-energy Soret fluorescence of hemoglobin peaked at 438\u2009nm with an extremely short lifetime becomes strongly visible under two-photon excitation. Based on the distinct spectral and temporal characteristics of hemoglobin fluorescence, we demonstrated that two-photon fluorescence microscopy could become a powerful tool for label-free in vivo imaging of microvasculature in tissue.",
        "keywords": [],
        "authors": [
            {
                "name": "Dong Li",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Wei Zheng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yan Zeng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yi Luo",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            }
        ],
        "venue": "Optics letters",
        "year": 2011
    },
    "pLLQGsDk": {
        "id": "pLLQGsDk",
        "title": "Real time near-infrared Raman spectroscopy for the diagnosis of nasopharyngeal cancer.",
        "abstract": "Near-infrared (NIR) Raman spectroscopy has been investigated as a tool to differentiate nasopharyngeal cancer (NPC) from normal nasopharyngeal tissue in an ex-vivo setting. Recently, we have miniaturized the fiber-optic Raman probe to investigate its utility in real time in-vivo surveillance of NPC patients. A posterior probability model using partial linear square (PLS) mathematical technique was constructed to verify the sensitivity and specificity of Raman spectroscopy in diagnosing NPC from post-irradiated and normal tissue using a diagnostic algorithm from three significant latent variables. NIR-Raman signals of 135 sites were measured from 79 patients with either newly diagnosed NPC (N = 12), post irradiated nasopharynx (N = 37) and normal nasopharynx (N = 30). The mean Raman spectra peaks identified differences at several Raman peaks at 853 cm-1, 940 cm-1, 1078 cm-1, 1335 cm-1, 1554 cm-1, 2885 cm-1 and 2940 cm-1 in the three different nasopharyngeal conditions. The sensitivity and specificity of distinguishing Raman signatures among normal nasopharynx versus NPC and post-irradiated nasopharynx versus NPC were 91% and 95%; and 77% and 96% respectively. Real time near-infrared Raman spectroscopy has a high specificity in distinguishing malignant from normal nasopharyngeal tissue in vivo, and may be investigated as a novel non-invasive surveillance tool in patients with nasopharyngeal cancer.",
        "keywords": [
            "PLS-DA model",
            "Raman spectroscopy",
            "nasopharyngeal cancer",
            "real time imaging",
            "surveillance"
        ],
        "authors": [
            {
                "name": "Lim Chwee Ming",
                "org": "Division of Surgical Oncology, National Cancer Institute of Singapore, Singapore."
            },
            {
                "name": "Nagaraja Rao Gangodu",
                "org": "Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore."
            },
            {
                "name": "Thomas Loh",
                "org": "Division of Surgical Oncology, National Cancer Institute of Singapore, Singapore."
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Jianfeng Wang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            },
            {
                "name": "Kan Lin",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Huang Zhiwei",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            }
        ],
        "venue": "Oncotarget",
        "year": 2017
    },
    "uNlPqlJo": {
        "id": "uNlPqlJo",
        "title": "Near-infrared Raman spectroscopy for optical diagnosis of gastric precancer",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "near infrared",
            "raman spectra",
            "medical diagnostics"
        ],
        "authors": [
            {
                "name": "seng khoon teh",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "d19YXhgt": {
        "id": "d19YXhgt",
        "title": "Fiber-optic Raman Spectroscopy with Nature-inspired Genetic Algorithms Enhances Real-time In Vivo Detection And Diagnosis of Nasopharyngeal Carcinoma.",
        "abstract": "Raman spectroscopy is an optical vibrational spectroscopic technique capable of probing specific biochemical structures and conformation of tissue and cells in biomedical systems. This work aims to assess the clinical utility of a fiber-optic Raman spectroscopy with nature-inspired genetic algorithms for enhancing in vivo detection and diagnosis of nasopharyngeal carcinoma (NPC) patients. The Raman diagnostic platform is developed based on simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic Raman endoscopy associated with genetic algorithms-partial least squares-linear discriminant analysis (GA-PLS-LDA). A total of 2126 in vivo FP/HW Raman spectra (598 NPC, 1528 normal) acquired from 113 tissue sites of 14 NPC patients and 48 healthy subjects during nasopharyngeal endoscopic examinations. Distinct Raman peaks have been identified (853 cm-1-proteins, 1209 cm-1-phenylalanine, 1265 cm-1-proteins, 1335 cm-1-proteins and nucleic acids, 1554 cm-1-tryptophan, porphyrin, 2885 cm-1-lipids, 2940 cm-1-proteins, 3009 cm-1-lipids, and 3250 cm-1-water) that are related to the significant biochemical changes (p < 1E-05) in NPC compared to normal tissue. Raman diagnostic performance is evaluated through leave-one-object (tissue site)-out cross-validation (LOOCV) method. Statistically significant GA-PLS-LDA model (p<1E-05) on FP/HW Raman yields a CV diagnostic accuracy of 98.23% (111/113), sensitivity of 93.33% (28/30) and specificity of 100% (83/83) for NPC classification. This work demonstrates that the fiber-optic FP/HW Raman diagnostic platform developed has great promise for improving real-time in vivo detection and diagnosis of NPC at the molecular level during clinical nasopharyngeal endoscopy.",
        "keywords": "",
        "authors": [
            {
                "name": "Petar \u017duvela",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Chi Shu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Chwee Ming Lim",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Analytical chemistry",
        "year": 2019
    },
    "oNZiQfNG": {
        "id": "oNZiQfNG",
        "title": "Simultaneous stimulated Raman scattering and higher harmonic generation imaging for liver disease diagnosis without labeling",
        "abstract": "",
        "keywords": [
            "chemicals",
            "optical microscopy",
            "raman scattering",
            "medical diagnostics",
            "high harmonic generation",
            "harmonic generation"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "zi wang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "jByKg0aS": {
        "id": "jByKg0aS",
        "title": "Fiber-optic Raman spectroscopy for in vivo diagnosis of gastric dysplasia",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianfeng wang",
                "org": ""
            },
            {
                "name": "kan lin",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "khek yu ho",
                "org": ""
            },
            {
                "name": "ming teh",
                "org": ""
            },
            {
                "name": "khay guan yeoh",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Faraday discussions",
        "year": 2015
    },
    "haR1a568": {
        "id": "haR1a568",
        "title": "Compact Raman needle probe with fine needle aspiration biopsy for solid tissues",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "medical diagnostics",
            "fabrication",
            "spectroscopy"
        ],
        "authors": [
            {
                "name": "jianfeng wang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "CoG6LtBF": {
        "id": "CoG6LtBF",
        "title": "Label-free three-dimensional imaging of cell nucleus using third-harmonic generation microscopy",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jian lin",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "zi wang",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2014
    },
    "3fLaP4IP": {
        "id": "3fLaP4IP",
        "title": "In vivo Raman spectroscopy integrated with multimodal endoscopic imaging for early diagnosis of gastric dysplasia",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "cancer",
            "nucleic acid",
            "raman spectra",
            "medical diagnostics",
            "near infrared",
            "system integration"
        ],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "kan lin",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Bios",
        "year": 2010
    },
    "HZjhQBv8": {
        "id": "HZjhQBv8",
        "title": "Classification of colonic tissues using Raman spectroscopy and multivariate techniques",
        "abstract": "",
        "keywords": [
            "colon cancer",
            "multivariate statistics",
            "algorithms",
            "raman spectroscopy",
            "medical diagnostics",
            "near infrared",
            "raman spectra",
            "cancer"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "effendi widjaja",
                "org": "national university of singapore"
            },
            {
                "name": "jianhua mo",
                "org": "national university of singapore"
            },
            {
                "name": "colin j r sheppard",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2006
    },
    "ZIyBiP5T": {
        "id": "ZIyBiP5T",
        "title": "Rapid Fiber-optic Raman Spectroscopy for Real-Time In Vivo Detection of Gastric Intestinal Metaplasia during Clinical Gastroscopy",
        "abstract": "We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) Raman spectroscopy technique coupled with a beveled fiber-optic Raman probe for improving in vivo detection of gastric intestinal metaplasia (IM)-precancerous lesions in real-time during clinical gastroscopy. A total of 4520 high-quality in vivo FP/HW gastric Raman spectra (normal=4178; IM=342) were acquired from 157 gastric patients undergoing endoscopic examination. Multivariate diagnostic algorithms based on principal components analysis and linear discriminant analysis together with the leave-one tissue site-out, cross-validation on in vivo tissue Raman spectra yield the diagnostic sensitivities of 89.3%, 89.3% and 75.0%; specificities of 92.2%, 84.4% and 82.0%; positive predictive values of 52.1%, 35.2% and 28.4%, and negative predictive values of 98.9%, 98.8% and 97.2%, respectively, by using the integrated FP/HW, FP, and HW Raman techniques for identifying IM from normal gastric tissue. Further receiver operating characteristic (ROC) curves generated show that the integrated FP/HW Raman technique gives the integration area under the ROC curve of 0.92 for IM classification, which is superior to either FP (0.89) or HW Raman (0.86) technique alone. This work demonstrates for the first time that the simultaneous FP/HW fiber-optic Raman spectroscopy has great potential to enhance early diagnosis of gastric precancer in vivo during routine endoscopic examination.",
        "keywords": "",
        "authors": [
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            },
            {
                "name": "Jianfeng Wang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Ming Teh",
                "org": "Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Khay Guan Yeoh",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            }
        ],
        "venue": "Cancer Prevention Research",
        "year": 2016
    },
    "VkJZuZiB": {
        "id": "VkJZuZiB",
        "title": "In vivo and simultaneous multimodal imaging: Integrated multiplex coherent anti-Stokes Raman scattering and two-photon microscopy",
        "abstract": "",
        "keywords": [
            "two photon microscopy",
            "nonlinear optics",
            "harmonic generation",
            "second harmonic generation",
            "higher order",
            "background subtraction",
            "pulse compression",
            "photonic crystal fiber",
            "raman spectra",
            "biological systems"
        ],
        "authors": [
            {
                "name": "dong li",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "yan zeng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2010
    },
    "KMdSdpSR": {
        "id": "KMdSdpSR",
        "title": "Autofluorescence spectroscopic imaging for laryngeal cancer detection",
        "abstract": "",
        "keywords": [
            "false positive rate",
            "medical diagnostics",
            "spectroscopy",
            "cancer",
            "measurement system"
        ],
        "authors": [
            {
                "name": "lin kan",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "yK1z2BCS": {
        "id": "yK1z2BCS",
        "title": "Near-field effects on coherent anti-Stokes Raman scattering microscopy imaging.",
        "abstract": "We introduce a numerical method, the finite-difference time-domain (FDTD) method, to study the near-field effects on coherent anti-Stokes Raman Scattering (CARS) microscopy on nanoparticles. Changes of the induced nonlinear polarization, scattering patterns, and polarization properties against different diameters of spherical nanoparticles are calculated and discussed in details. The results show that due to near-field effects, the induced nonlinear polarization is significantly enhanced at the water-particle interface, with 1.5-fold increase in intensity compared to that inside the particles, and the near-field enhancement increases with decreasing diameters of nanoparticles. The enhanced scattering dominates over the scattering contribution from the particles when the nanoparticle size decreases down to the scale of less than a half wavelength of excitation light. Further studies show that near-field effects make the induced perpendicular polarization of CARS signals being strictly confined within the nanoparticles and the particle-water interface, and this perpendicular polarization component could contribute approximately 20% to the backward scattering. The ratio values of the perpendicular polarization component to the total CARS signals from nanoparticles sizing from 75 nm to 300 nm in backward scattering are approximately 3 to 5 times higher than those in forward scattering. Therefore, near-field effects can play an important role in CARS imaging. Employing the perpendicular polarization component of CARS signals can significantly improve the contrast of CARS images, and be particularly useful for revealing the fine structures of bio-materials with nano-scale resolutions.",
        "keywords": [
            "fine structure",
            "finite difference time domain",
            "near field",
            "three dimensional",
            "numerical method",
            "nonlinear optics"
        ],
        "authors": [
            {
                "name": "Cheng Liu",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            },
            {
                "name": "Fake Lu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Dietmar W. Hutmacher",
                "org": ""
            },
            {
                "name": "Colin Sheppard",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2007
    },
    "kxgx8JZm": {
        "id": "kxgx8JZm",
        "title": "Polarization-resolved second-harmonic generation imaging for liver fibrosis assessment without labeling",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jian lin",
                "org": ""
            },
            {
                "name": "shiying pan",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2013
    },
    "Wk87RM59": {
        "id": "Wk87RM59",
        "title": "Fiber-optic Raman probe couples ball lens for depth-selected Raman measurements of epithelial tissue.",
        "abstract": "In this study, we present a fiber-optic ball lens Raman probe design for improving depth-selected Raman measurements of epithelial tissue. The Monte Carlo simulation results show that tissue Raman collection efficiency can be improved by properly selecting the refractive index and the diameter of the ball lens for the Raman probe design and the depth-selectivity of Raman measurements can also be improved by either increasing the refractive index or reducing the diameter of the ball lens. An appropriate arrangement of the Raman probe-tissue distance can also optimize the collection efficiency for depth-resolved Raman measurements. Experimental evaluation of a ball lens Raman probe design on a two-layer tissue phantom confirms the potential of the ball lens Raman probe design for efficient depth-selected measurement on epithelial tissue. This work suggests that the fiber-optic Raman probe coupled with a ball lens can facilitate the depth-selected Raman measurements of epithelial tissue, which may improve the diagnosis of epithelial precancer and early cancer at the molecular level.",
        "keywords": [
            "fiber optic",
            "biomedical research",
            "raman spectroscopy",
            "bioinformatics"
        ],
        "authors": [
            {
                "name": "Jianhua Mo",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Biomedical optics express",
        "year": 2010
    },
    "XJZ2oeeN": {
        "id": "XJZ2oeeN",
        "title": "Integrated autofluorescence endoscopic imaging and point-wise spectroscopy for real-time in vivo tissue measurements.",
        "abstract": "We report on the development of an integrated point-wise spectroscopy and autofluorescence (AF) endoscopic imaging technique for real-time in vivo tissue measurements at endoscopy. We implement a unique point spectrum optical design to realize real-time AF imaging and AF or diffuse reflectance (DR) spectroscopy measurements from a small area of tissue of interest on the AF image. We demonstrate that both the AF image and the point-wise AF/DR spectra can be simultaneously acquired from the oral cavity in vivo within 0.1 s, suggesting the potential of the integrated spectroscopy and endoscopic imaging technique developed to facilitate in vivo tissue diagnosis and characterization at endoscopy.",
        "keywords": [
            "real time",
            "spectroscopy",
            "diffuse reflectance",
            "fluorescence spectroscopy"
        ],
        "authors": [
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2010
    },
    "VyL6ixEt": {
        "id": "VyL6ixEt",
        "title": "Near-infrared Fluorescence Imaging for Colonic Cancer Diagnosis",
        "abstract": "",
        "keywords": [
            "near infrared",
            "optical imaging",
            "fluorescence imaging",
            "colon cancer",
            "cancer",
            "fluorescence"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "xiaozhuo shao",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "colin j r sheppard",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "E69jQtkU": {
        "id": "E69jQtkU",
        "title": "Near-infrared Mueller matrix imaging for colonic cancer detection",
        "abstract": "Mueller matrix imaging along with polar decomposition method was employed for the colonic cancer detection by polarized light in the near-infrared spectral range (700\u20131100 nm). A high-speed (u003c5s) Muller matrix imaging system with dual-rotating waveplates was developed. 16 (4 by 4) full Mueller matrices of the colonic tissues (i.e., normal and caner) were acquired. Polar decomposition was further implemented on the 16 images to derive the diattentuation, depolarization, and the retardance images. The decomposed images showed clear margin between the normal and cancerous colon tissue samples. The work shows the potential of near-infrared Mueller matrix imaging for the early diagnosis and detection of malignant lesions in the colon.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianfeng Wang",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Kan Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "7f1JSKdN": {
        "id": "7f1JSKdN",
        "title": "Raman spectroscopy for optical diagnosis of laryngeal cancer",
        "abstract": "",
        "keywords": [
            "cancer",
            "near infrared",
            "algorithms",
            "raman spectroscopy",
            "multivariate statistics",
            "raman spectra",
            "medical diagnostics"
        ],
        "authors": [
            {
                "name": "seng khoon teh",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "david p lau",
                "org": "singapore general hospital"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "XPqe6Wqo": {
        "id": "XPqe6Wqo",
        "title": "Detection of malignant lesions in vivo in the upper gastrointestinal tract using image-guided Raman endoscopy",
        "abstract": "",
        "keywords": [
            "medical diagnostics",
            "algorithms",
            "digestive system",
            "near infrared",
            "cancer",
            "raman spectroscopy",
            "reflectivity"
        ],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "kan lin",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "jimmy bok yan so",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2012
    },
    "eeNrQctt": {
        "id": "eeNrQctt",
        "title": "Evaluation of a fiber probe coupled with half ball lens for depth-resolved fluorescence measurements",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "lenses",
            "luminescence"
        ],
        "authors": [
            {
                "name": "franck jaillon",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "fUoalSTF": {
        "id": "fUoalSTF",
        "title": "Combining near-infrared autofluorescence and Raman spectroscopy improves the in vivo detection of cervical precancer",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "huang",
                "org": ""
            },
            {
                "name": "jianhua mo",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "jeffrey low",
                "org": ""
            },
            {
                "name": "joseph ng",
                "org": ""
            },
            {
                "name": "ilancheran",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "7OdeMFK4": {
        "id": "7OdeMFK4",
        "title": "High-resolution stimulated Raman scattering microscopy by focal-field modulation",
        "abstract": "We report on a high-resolution stimulated Raman scattering (SRS) microscopy by phase modulation of the pump beam. In this study, an optimized phase pattern is applied to the pump beam by a spatial light modulator to minimize its focal spot size. Simulation shows that the central lobe of focused pump beam is reduced to around half of its original size, and the full-width at half-maximum of corresponding SRS distribution is reduced to less than 65% after focal-field modulation. We demonstrate this scheme by measuring the pump beam focal spot size and SRS imaging of PMMA beads.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "arABG7Ek": {
        "id": "arABG7Ek",
        "title": "Real-time In vivo Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Chwee Ming Lim",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Theranostics",
        "year": 2017
    },
    "qfBQCjso": {
        "id": "qfBQCjso",
        "title": "In vivo early diagnosis of gastric dysplasia using narrow-band image-guided Raman endoscopy.",
        "abstract": "We first report on the implementation of a novel narrow-band image-guided Raman endoscopy technique for in vivo diagnosis of gastric dysplasia. High-quality in vivo Raman spectra can be acquired from normal and dysplastic gastric mucosal tissue within 0.5 sec under narrow-band image (NBI) guidance at gastroscopy. Significant differences are observed in in vivo Raman spectra between normal (n=54) and dysplastic (n=18) gastric tissue from 30 gastric patients, particularly in the spectral ranges of 825 to 950, 1000 to 1100, 1250 to 1500, and 1600 to 1800 cm(-1), which primarily contain signals related to proteins, nucleic acids, and lipids. The multivariate analysis [i.e., principal components analysis (PCA) and linear discriminant analysis (LDA)], together with the leave-one tissue site-out, cross validation on in vivo gastric Raman spectra yields a diagnostic sensitivity of 94.4% (1718) and specificity of 96.3% (5254) for distinction of gastric dysplastic tissue. This study suggests that narrowband image-guided Raman endoscopy associated with PCA-LDA diagnostic algorithms has potential for the noninvasive, in vivo early diagnosis and detection of gastric precancer during clinical gastroscopic examination.",
        "keywords": [
            "gastric dysplasia",
            "narrow-band imaging",
            "precancer.",
            "raman endoscopy",
            "in vivo diagnosis",
            "gastroscopy",
            "raman spectra",
            "principal component analysis",
            "raman spectroscopy",
            "medical diagnostics",
            "nucleic acid",
            "multivariate analysis",
            "cross validation",
            "algorithms"
        ],
        "authors": [
            {
                "name": "Zhiwei Huang",
                "org": ""
            },
            {
                "name": "Mads Sylvest Bergholt",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2010
    },
    "Qko7dGg5": {
        "id": "Qko7dGg5",
        "title": "Integrated multiplex CARS and two-photon fluorescence microscopy for imaging biological systems",
        "abstract": "",
        "keywords": [
            "photons",
            "second harmonic generation",
            "photonic crystal fiber",
            "biological systems",
            "photonic crystal fibers",
            "near infrared",
            "femtosecond laser",
            "luminescence",
            "nonlinear optics",
            "optical microscopy",
            "microscopy",
            "biomedical imaging"
        ],
        "authors": [
            {
                "name": "dong li",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "EZit3SSz": {
        "id": "EZit3SSz",
        "title": "Hyperspectral stimulated Raman scattering and multiphoton imaging for digital pathology of colonic disease",
        "abstract": "Histopathology examinations of Hu0026E stained biopsied tissues is the golden standard for colonic diseases (e.g., polyps, adenoma, and adenocarcinoma) diagnosis. However, staining effect of sample and doctoru0027s expertise degree may greatly influence the diagnosis results. The information provided by the Hu0026E stained sample is also limited to the morphological and PH information and no quantative information is available. In this paper, we report the development of a unique multimodal nonlinear optical microscopy (i.e., hyperspectral stimulated Raman scattering (hsSRS), second-harmonic generation (SHG), third-harmonic generation (THG), two-photon excitation fluorescence (TPEF)) platform for the diagnosis and characterization of colonic diseases. HsSRS in both fingerprint (800\u20131800 cm -1 ) and high-wavenumber (2800\u20133600 cm -1 ) regions allows us to discriminate different constituents with tiny difference in the Raman spectra. The increase of proteins and reduction of lipids could be observed with the progress of colonic cancer. SHG shows the distribution of collagen, which is found to aggregate for adenocarcinoma. TPEF provides the cell morphological and can reflect the damage inside glands caused by the diseases. THG shows the increase of optical heterogeneity related to cancer process. This work shows that the integrated hsSRS and TPEF/SHG/THG imaging technique can be an effective method for digital pathology of colonic diseases at the molecular and sub-cellular levels.",
        "keywords": "",
        "authors": [
            {
                "name": "Zi Wang",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Jian Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "m1JNubgh": {
        "id": "m1JNubgh",
        "title": "Mechanism of two-photon excited hemoglobin fluorescence emission",
        "abstract": "",
        "keywords": [
            "luminescence",
            "photons"
        ],
        "authors": [
            {
                "name": "qiqi sun",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "chinese academy of sciences"
            },
            {
                "name": "jiannong wang",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "yi luo",
                "org": "university of science and technology of china"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "Journal of Biomedical Optics",
        "year": 2015
    },
    "k7KVhRW1": {
        "id": "k7KVhRW1",
        "title": "Simultaneous fingerprint and high-wavenumber Raman endoscopy for in vivo diagnosis of colorectal precancer",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "medical diagnostics",
            "fingerprint recognition",
            "fiber optics"
        ],
        "authors": [
            {
                "name": "kan lin",
                "org": "national university of singapore"
            },
            {
                "name": "jianfeng wang",
                "org": "national university of singapore"
            },
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "hongzhi xu",
                "org": "xiamen university"
            },
            {
                "name": "jianlin ren",
                "org": "xiamen university"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "FkOawre0": {
        "id": "FkOawre0",
        "title": "Elliptically Polarized Coherent Anti-Stokes Raman Scattering Microscopy for High Contrast Vibrational Imaging",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "fake lu",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Ntm",
        "year": 2009
    },
    "reBVAAQr": {
        "id": "reBVAAQr",
        "title": "Classification of ENT tissue using near-infrared Raman spectroscopy and support vector machines",
        "abstract": "",
        "keywords": [
            "principal component analysis",
            "radial basis function",
            "principal component",
            "data collection",
            "support vector machine",
            "raman spectroscopy",
            "pattern recognition",
            "near infrared"
        ],
        "authors": [
            {
                "name": "effendi widjaja",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "huang zhiwei",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2005
    },
    "AJxRCGMs": {
        "id": "AJxRCGMs",
        "title": "Combining near-infrared-excited autofluorescence and Raman spectroscopy improves in vivo diagnosis of gastric cancer",
        "abstract": "This study aims to evaluate the diagnostic utility of the combined near-infrared (NIR) autofluorescence (AF) and Raman spectroscopy for improving in vivo detection of gastric cancer at clinical gastroscopy. A rapid Raman endoscopic technique was employed for in vivo spectroscopic measurements of normal ( n = 1098) and cancer ( n = 140) gastric tissues from 81 gastric patients. The composite NIR AF and Raman spectra in the range of 800\u20131800 cm \u22121 were analyzed using principal component analysis (PCA) and linear discriminant (LDA) to extract diagnostic information associated with distinctive spectroscopic processes of gastric malignancies. High quality in vivo composite NIR AF and Raman spectra can routinely be acquired from the gastric within 0.5 s. The integrated intensity over the range of 800\u20131800 cm \u22121 established the diagnostic implications ( p = 1.6E\u221214) of the change of NIR AF intensity associated with neoplastic transformation. PCA\u2013LDA diagnostic modeling on the in vivo tissue NIR AF and Raman spectra acquired yielded a diagnostic accuracy of 92.2% (sensitivity of 97.9% and specificity of 91.5%) for identifying gastric cancer from normal tissue. The integration area under the receiver operating characteristic (ROC) curve using the combined NIR AF and Raman spectroscopy was 0.985, which is superior to either the Raman spectroscopy or NIR AF spectroscopy alone. This work demonstrates that the complementary Raman and NIR AF spectroscopy techniques can be integrated together for improving the in vivo diagnosis and detection of gastric cancer at endoscopy. Keywords Raman spectroscopy In vivo optical diagnosis Gastric cancer Near-infrared autofluorescence Gastroscopy 1 Introduction Gastric cancers remain a severe disorder with high mortality rates ( Axon, 2006; Verdecchia et al., 2003 ), particularly in the east-Asia region where the lifetime risk in some regions exceeds 10% ( Yaghoobi et al., 2010 ). The early detection and localization of abnormalities with appropriate curative treatment (e.g., endoscopic mucosal resection (EMR) and/or radiation therapy in combination with chemotherapy) is critical to decreasing the mortality rate ( Leung et al., 2008 ). However, the accurate identification and localization of early lesions (i.e., dysplasia and carcinoma in situ (CIS)) and flat mucosal cancers in the gastric can be very challenging for clinicians using conventional white-light reflectance (WLR) endoscopy ( Leung et al., 2008 ). Very recently, autofluorescence imaging (AFI) ( Falk, 2009 ) and narrowband imaging (NBI) ( Overhiser and Sharma, 2008 ) have emerged as diagnostic tools but these techniques remain inadequate for the objective and accurate diagnosis of dysplastic or early neoplastic lesions during routine endoscopic examinations ( Falk, 2009 ). While excisional biopsy remains the standard approach for gastric cancer diagnosis, it is invasive and impractical as a routine screening tool for high-risk patients who may have multiple suspicious lesions. Furthermore, accurate identification of the tumor margins is of considerable clinical importance, in particular for the diffuse type of gastric cancer where the boundaries of the lesion can be indistinct and nests of cancerous cells may be found at a distance from the visible tumor margin. Therefore, the development of an advanced optical diagnostic technique that could identify and diagnose early cancerous lesions in vivo would be of significant clinical value during routine endoscopic inspections. Recently near-infrared (NIR) Raman spectroscopy has excelled in the early optical detection of precancer and cancer in a number of internal organs including the stomach with high diagnostic specificities ( Lau et al., 2003; Widjaja et al., 2008; Teh et al., 2008a,b, 2009a,b, 2010a,b; Stone et al., 2004; Nijssen et al., 2009; Mahadevan-Jansen and Richards-Kortum, 1996; Huang et al., 2003, 2005, 2010a,b; Bergholt et al., 2010a,b ). NIR Raman spectroscopy is a nondestructive, inelastic light scattering technique in which the incident laser light is shifted in frequency depending on the specific vibrational motion of molecules. The vibrational Raman spectrum of biological tissue reflects the biochemical surface and subsurface inter/intra-cellular structures and conformations (i.e. biochemical signatures) ( Mahadevan-Jansen and Richards-Kortum, 1996; Stone et al., 2004; Huang et al., 2003, 2005 ) providing the unique opportunity to distinguish between different tissue types at the biomolecular level. For instance, the diagnostic sensitivities (of \u223c85\u201395%) and specificities (of \u223c90\u201398%) have been reported for differentiation between different pathologic types (e.g., intestinal metaplasia, helicobacter pylori infection, dysplasia and adenocarcinoma) of gastric tissues in vitro using NIR Raman spectroscopy associated with multivariate statistical analysis ( Teh et al., 2008a,b, 2009a, 2010a,b ). Very recently, we have further extended the previous in vitro gastric Raman studies into realization of real-time in vivo Raman spectroscopy during routine clinical gastroscopic inspections ( Huang et al., 2009 ). Consequently, the accurate in vivo diagnosis of gastric dysplasia ( Huang et al., 2010a ), neoplasia ( Huang et al., 2010b; Bergholt et al., 2010a ), differential diagnosis between benign and malignant ulcers ( Bergholt et al., 2010b ) and in vivo diagnosis of esophageal cancers ( Bergholt et al., 2011a ) have been demonstrated with success. Further, the in vivo Raman spectral inter-anatomical variability has been evaluated as well, indicating subtle spectral variations within the normal stomach ( Bergholt et al., 2011b ). However, tissue Raman spectra in the fingerprint region (e.g., 800\u20131800 cm \u22121 ) contain concomitant inherently intense autofluorescence (AF) signals, which are typically removed by means of different filtering methodologies (e.g., differentation, polynomial fitting, fourier transform, wavelets, shifted subtracted Raman spectroscopy (SSRS), etc.) ( Huang et al., 2003; Zhao et al., 2007 ) to enhance the highly molecular specific Raman bands for tissue classification and characterization. The autofluorescence background is a broad band light re-emission from endogenous fluorophores that are excited by photons and has shown promise in differentiating cancerous from normal tissue because of tumor-associated changes in morphological structures, tissue absorption, scattering or endogenous fluorophore content and distribution ( Huang et al., 2004, 2005; Mayinger et al., 2004; Chwirot. et al., 1997; Shao et al., 2010; Lieber and Kabeer, 2010; Han et al., 2009 ). Most autofluorescence studies have been limited to ultraviolet (UV)/visible regions, over which NIR spectroscopy holds significant advantages, such as non-carcinogenic with relatively low sensitivity to water and deeper light penetration of tissues ( Shao et al., 2010 ). For instance, it has been shown that NIR Raman and NIR AF spectroscopy techniques provide complementary diagnostic information for detecting cancers in murine tumor models when coupled with principal component analysis (PCA) and linear discriminant analysis (LDA) ( Huang et al., 2005 ). Very recently, the diagnostic capability of NIR AF imaging for colonic cancer diagnosis has been demonstrated in vitro ( Shao et al., 2010 ). In this work, we evaluated the diagnostic utility of combining NIR AF and Raman spectroscopy for improving gastric cancer diagnosis at endoscopy. Multivariate analysis (i.e., PCA\u2013LDA) was employed to extract the significant diagnostic information associated with the NIR AF and Raman signals of gastric malignancies. 2 Materials and methods 2.1 Raman endoscopy instrumentation Fig. 1 shows the integrated Raman spectroscopy and trimodal wide-field imaging system developed for in vivo tissue measurements and characterization at endoscopy ( Huang et al., 2001; Huang et al., 2009 ). Briefly, the Raman endoscopy system consists of a spectrum stabilized 785 nm diode laser (maximum output: 300 mW, B&W TEK Inc., Newark, DE), a transmissive imaging spectrograph (Holospec f/1.8, Kaiser Optical Systems) equipped with a cryogenic cooled, NIR-optimized, back-illuminated and deep depletion charge-coupled device (CCD) camera (1340 \u00d7 400 pixels at 20 \u00d7 20 \u03bcm per pixel; Spec-10: 400BR/LN, Princeton Instruments), and a specially designed Raman endoscopic probe for both laser light delivery and in vivo tissue Raman signal and NIR AF collection. The novel Raman probe is composed of 32 collection fibers surrounding the central light delivery fiber with two stages of optical filtering incorporated at the proximal and distal ends of the probe for maximizing the collection of tissue Raman signals while reducing the interference of Rayleigh scattered light, fiber fluorescence and silica Raman signals. The Raman probe can pass down through the instrument channel of medical endoscopes and be directed to all anatomical tissue sites under the guidance of wide-field endoscopic imaging (WLR/AFI/NBI) modalities ( Huang et al., 2009 ). Control of the in vivo Raman endoscopy system was implemented by a personal computer (PC) using a custom-designed software that triggers on-line data acquisition and analysis (e.g., CCD dark-noise subtraction, wavelength calibration, system spectral response calibration, signal saturation detection, cosmic ray rejection, etc.), as well as real-time display of in vivo tissue Raman spectra during clinical endoscopic measurements. The spectral resolution of the system is 9 cm \u22121 . All wavelength-calibrated spectra were corrected for the wavelength-dependence of the system using a standard lamp (RS-10, EG&G Gamma Scientific, San Diego, CA) and scaled with integration time. The system acquires raw Raman spectra in the wavenumber range of 800\u20131800 cm \u22121 from in vivo gastric tissue within 0.5 s using the 785 nm excitation power of 1.5 W/cm 2 . The trimodal endoscopy imaging system primarily comprises a 300 W short-arc xenon light source, a gastrointestinal (GI) videoscope (GIF-FQ260Z, Olympus), and a video system processor (CV-260SL, Olympus). The widefield light reflected or emitted from tissue are detected by two monochrome CCD chips mounted behind the two objective lenses placed next to each other at the distal tip of the GI videoscope: one CCD for WLR/NBI and the other one for AFI. With this unique image-guided Raman spectroscopy system, wide-field endoscopic images (WLR/AFI/NBI) and the corresponding in vivo raw spectra (composite Raman and NIR AF) of the tissue imaged can be simultaneously acquired, displayed and recorded in the video system processor and the PC, respectively. 2.2 Data preprocessing The raw spectra acquired from tissue in the 800\u20131800 cm \u22121 range were composed of prominent tissue NIR AF emission and a much weaker tissue Raman scattered signal. Initially, the composite NIR AF and Raman spectra were preprocessed by adjacent five-point Savitzky Golay smoothing filter to reduce noise. The spectral preprocessing is completed on-line and the composite NIR AF and Raman spectrum and clinical outcome (e.g. of diagnostic decision algorithms developed) can be displayed in real-time in a comprehensible graphical user interface (GUI) during clinical measurements at endoscopy. 2.3 Patients The present study is part of an ongoing nationwide program aiming at early diagnosis and treatment of upper GI malignancies run by the Singapore gastric cancer epidemiology, clinical and genetic program ( Leung et al., 2008; Yeoh, 2007 ). This study was conducted with approval by the Institutional Review Board (IRB) of the National Healthcare Group (NHG) of Singapore. All patients provided written informed consent for participation in the study at the National University Hospital (NUH), Singapore. In this work, 81 patients of different races (47 men and 34 women with a median age of 66 years old) were enrolled for in vivo Raman spectroscopy under the guidance of multimodal wide-field imaging modalities (WLR/AFI/NBI) ( Huang et al., 2009 ). The Raman probe was passed into the endoscope instrument channel and placed in gentle contact with the gastric mucosal surface and the accurate positioning against the mucosa was verified on the endoscopy monitor by the clinicians in-charge during endoscopic examinations. As a result, a total number of 1238 in vivo raw (composite NIR AF and Raman) spectra of 176 tissue sites were collected from the gastric (antrum, body and cardia), in which 1098 spectra were measured from normal mucosa while 140 spectra were from suspicious neoplasms. Immediately after Raman spectroscopic acquisitions, the biopsy samples were taken from the tissue sites measured (with suction markings) and fixed in 10% formalin solution for histopathological confirmation of normal or cancerous tissue types by a senior gastrointestinal pathologist who was blinded to the NIR AF and Raman spectroscopy results. The histopathology results served as the gold standard. The histopathological findings indicated adenocarcinomas ( n = 132) and mucosa associated lymphoid tissue (MALT) lymphoma ( n = 8). The normal (benign) tissues were primarily associated with absence of pathology or mild to moderate gastritis. 2.4 Multivariate statistical analysis The high dimensionality of the spectral space (each raw spectrum ranging from 800 to 1800 cm \u22121 with a set of 685 intensities) will result in inefficiency in implementation and optimization of conventional statistical analysis and clustering algorithms (e.g., linear discriminant analysis (LDA), etc.) ( Stone et al., 2004; Nijssen et al., 2009; Teh et al., 2010a; Huang et al., 2010a; Bergholt et al., 2010a ). To reduce the dimension of the spectral data, PCA can be employed to extract a set of orthogonal principal components (PCs) comprising loadings and scores that account for the maximum variance in spectral datasets ( Teh et al., 2008a ). Each loading vector is related to the original spectrum by the PC score, which represents the weight of that particular component against the basis spectrum. Hence, the loadings and scores of the PCA model provide insights into the underlying structure in spectroscopic data. This is especially appealing in the context of resolving spectral variations associated with distinct spectroscopic processes (e.g., autofluorescence and Raman spectra). In this study, to render diagnostic algorithms, the significant PCs ( p < 0.05) were fed to a LDA classifier. LDA determines the discriminant function that maximizes the variances between groups while minimizing the variances between members of the same group. The performance of the PCA\u2013LDA diagnostic algorithm was validated using the leave-one tissue site-out, cross-validation methodology ( Picard and Cook, 1984 ). In this validation procedure, one tissue site (6\u20138 spectra) was left out and the PCA\u2013LDA modeling was redeveloped using the remaining spectra. The redeveloped PCA\u2013LDA diagnostic algorithm was then used to classify the withheld spectra. This process was repeated iteratively until all withheld spectra were classified. To further assess the performance of the PCA\u2013LDA modeling for tissue classification, receiver operating characteristic (ROC) curves were generated by successively changing the thresholds to determine correct and incorrect classifications for all subjects. Multivariate statistical analysis was performed using in-house written scripts in the Matlab (Mathworks Inc., Natick, MA) programming environment. 3 Results High quality in vivo composite NIR AF and Raman spectra can routinely be acquired from normal and cancerous gastric mucosa in real-time (<0.5 s) under multimodal imaging-guidance (WLR, NBI and AFI) during clinical gastroscopic examinations. Fig. 2 shows the in vivo mean composite NIR AF and Raman spectra \u00b11 standard errors (SE) of cancerous and normal gastric tissues together with the difference spectra (cancer \u2212 normal) \u00b1 1 SE. Overall, the mean spectra represent the decreasing broadband NIR AF curves with varying intensities, whereas highly specific Raman bands are superimposed on the intense NIR AF spectra and identified at the following peak positions with tentative biomolecular assignments ( Stone et al., 2004; Teh et al., 2008a,b, 2010a; Huang et al., 2010b; Mahadevan-Jansen and Richards-Kortum, 1996 ): 853 cm \u22121 ( \u03bd (C\u2013C) of proline), 936 cm \u22121 ( \u03bd (C\u2013C) of proteins), 1004 cm \u22121 ( \u03bd (C\u2013C) symmetric ring breathing of phenylalanine), 1078 cm \u22121 ( \u03bd (C\u2013C) of lipids), 1265 cm \u22121 (Amide III \u03bd (C\u2013N) and \u03b4 (N\u2013H) of proteins), 1302 ( \u03b4 (CH 2 ) deformation of proteins and lipids), 1445 cm \u22121 ( \u03b4 (CH 2 ) of proteins and lipids), 1618 cm \u22121 ( \u03bd (C C) of porphyrins), 1655 cm \u22121 (Amide I \u03bd (C O) of proteins) and 1745 cm \u22121 ( \u03bd (C O) of lipids). The integrated NIR AF intensity over the range of 800\u20131800 cm \u22121 shows a significant decrease ( p = 1.6E\u221214) associated with neoplastic tissue transformation indicating the potential application of in vivo NIR AF spectroscopy in clinical diagnostics. Further, over 35 reference composite NIR AF and Raman spectra were also measured from major biochemicals associated with gastrointestinal tissue (e.g., glycogen, flavin, DNA, collagen, mucins, pepsinogen, actin, elastin, NADH, porphyrin, etc.) ( Huang et al., 2010b ). A selection of most prominent fluorophores that could be involved in gastric tissue NIR AF variations based on the non-negativity-constrained least-squares minimization (NNCLSM)) modeling ( Huang et al., 2010b; Bergholt et al., 2010a,b ) are presented in Fig. 3 A (i.e., elastin, pepsinogen, mucin, collagen, DNA and glycogen), indicating subtle NIR spectral shape changes of endogenous fluorophores in gastric tissue. Based on these reference NIR AF spectra, a semi-quantitative diagnostic regression model was rendered using NNCLSM for tissue NIR AF spectral reconstruction ( Huang et al., 2010b; Bergholt et al., 2011a ). The measured and reconstructed spectra are shown in Fig. 3 B and the minute fit residuals (normal: \u00b14E\u221203; cancer: \u00b11E\u221203) suggest the potential implications of these specific NIR fluorophores for gastric tissue diagnosis. Based on this combined NIR AF and Raman model, a diagnostic accuracy of 79.2% (sensitivity of 93.6% (131/140) and specificity of 77.3% (849/1098)) could be achieved using LDA for detection of gastric neoplasms in vivo . These findings indicate that there is a considerable change in the percentage of distinctive Raman-active biomolecules and NIR fluorescence constituents in different gastric tissue types. Prior to multivariate analysis, the NIR AF and Raman spectral dataset were mean centered in order to remove common variance ( Smilde et al., 2005; Bergholt et al., 2010b ). Subsequently, a PCA model was fitted and cross validated. An outlier detection based on Q residuals and Hotelling T 2 plots ( Smilde et al., 2005 ) were employed to remove spectra that showed abnormal intensity and line shape variation (e.g., due to non-contact measurements). Fig. 4 shows the diagnostic significant PC loadings ( p < 0.05) calculated using PCA together with the percentage of spectral variation captured by each of the respective PCs (PC1 \u2013 99.930%; PC5 \u2013 0.007%; PC10 \u2013 0.004%; PC11 \u2013 0.003%). These components are further fed to a LDA classifier, and the cross-validated classification results (posterior probabilities) belonging to normal and cancer categories are shown in Fig. 5 A . The diagnostic accuracy of 92.2% (sensitivity of 97.9% (137/140) and specificity of 91.5% (1005/1098)) can be achieved using the composite NIR AF and Raman spectroscopy for in vivo gastric cancer detection. Obviously, PC1 (PC1 \u2013 99.970%) essentially represents the diagnostically significant NIR AF background intensity whereas PC5, PC10 and PC11 primarily represent the molecule-specific Raman signals (e.g., at 853, 1004, 1078, 1302, 1335, 1440, 1618, 1655 and 1745 cm \u22121 ) ( Fig. 4 ). To evaluate the diagnostic ability of Raman spectroscopy, a PCA\u2013LDA model based on PC5, PC10, PC11 was rendered achieving the accuracy of 89.7% (sensitivity of 92.9% (130/140) and specificity of 89.3% (980/1098)) ( Fig. 5 B). We also assessed the diagnostic information in the NIR AF signal (PC1) achieving the diagnostic accuracy of 86.3% (sensitivity of 98.6% (138/140) and specificity of 84.7% (930/1098)) ( Fig. 5 C). To further evaluate the class separations, the ROC-curves were also generated for the three techniques (i.e., composite NIR AF and Raman; Raman; NIR AF) ( Fig. 6 ). The integration areas under the ROC curves (AUC) were 0.985, 0.967 and 0.952 for the composite NIR AF and Raman, Raman and NIR AF models, respectively, demonstrating that combining NIR AF and Raman spectroscopy gives the best diagnostic performance for gastric cancer diagnosis as compared to the NIR AF spectroscopy and Raman spectroscopy alone. 4 Discussion Extensive research in the field of noninvasive optical diagnostics (i.e., optical biopsy) is being directed towards the spectroscopic technologies for in vivo tissue diagnosis and characterization. Our recently developed image-guided Raman spectroscopic technique ( Huang et al., 2009 ) offers the advantages of directly multiparametric (e.g., morphological structures, biomolecular and biochemical constituents) assessment of tissue in vivo without artefacts introduced by mechanically cutting, oxidation, hydration, loss of mucus layer and vascular pressure, etc. ( Huang et al., 2009, 2010a,b; Bergholt et al., 2010a,b ). Most studies have evaluated tissue Raman spectra in isolation without taking into account the concomitant endogenous NIR autofluorescence signal, which is often considered as meaningless. But tissue autofluorescence, in fact, contains diagnostic information related to tissue morphology and distribution of endogenous fluorophores that can be utilized for diagnosis ( Falk, 2009; Huang et al., 2004, 2005; Lieber and Kabeer, 2010; Mayinger et al., 2004; Chwirot. et al., 1997; Shao et al., 2010; Han et al., 2009 ). In this work, we employed the PCA\u2013LDA methodology as a means to combining endogenous NIR AF and Raman spectroscopy under 785 nm laser excitation for improving the detection of gastric neoplasia in vivo . The PCA modeling of the composite NIR AF and Raman spectra rendered complex PC loadings ( Fig. 4 ) essentially revealing the NIR AF (intense decreasing broadband curves) and Raman features (highly molecular specific resolved peaks) of gastric tissue, substantiating that the PCA model was able to extract the diagnostic information carried by both the Raman scattered and NIR AF emitted light from gastric tissue. For instance, loading on PC1 can essentially be associated with NIR AF spectra accounting for a large spectral variation (99.930%), indicating that the NIR AF intensity is of dominant diagnostic values for detection of gastric cancer. The significant NIR AF emission reduction ( p = 1.6E\u221214) and spectral line shape modification associated with PC1 suggest that there was an important concentration change in NIR fluorophores and/or tissue morphology in gastric mucosa associated with carcinogenic tissue transformation. It has been reported that collagen could be a major contributor to the tissue NIR AF spectrum ( Huang et al., 2005; Lieber and Kabeer, 2010; Shao et al., 2010 ), which is in agreement with the reports that cancerous cells proliferate, invade into underlying stromal layer and express a class of metalloproteases ( Curran and Murray, 1999 ), resulting in an overall reduction of collagen content in neoplastic tissue. Furthermore, increased epithelial proliferation and replacement with tumor cells attenuating the excitation light and NIR AF signals from the lamina propria might also contribute to this finding. This morphological effect has also been observed in Raman and UV/visible autofluorescence spectroscopy and imaging studies ( Bergholt et al., 2010a; Mayinger et al., 2004; Shao et al., 2010 ). Besides, the angiogenesis occurring in neoplastic tissue may also contribute to NIR AF re-absorption due to increased blood content, and hence, the reduction of NIR AF signals could partly reflect the status of micro-vascularities associated with gastric malignancies. To grossly evaluate the change in tissue NIR AF fluorophores, the composite NIR AF and Raman spectra of some biochemicals (i.e., collagen, pepsinogen, elastin, mucin, glycogen and DNA) that exhibit significant NIR AF signal are shown in Fig. 3 A. The fitted spectra ( Fig. 3 B) derived from a semi-quantitative diagnostic NNCLSM regression model ( Fig. 3 B) demonstrated diminutive fit residuals (normal: \u00b14E\u221203; cancer: \u00b11E\u221203) and good diagnostic discrimination (i.e., accuracy of 79.2% (sensitivity of 93.6% and specificity of 77.3%)). Therefore, NIR AF spectroscopy is a novel approach for identifying gastric tissue pathologic changes (e.g., microvascular changes, metabolic alterations, inflammatory changes, loss of glandular mucosa, etc.) ( Mayinger et al., 2004 ) associated with neoplastic transformation. We also demonstrated that the PCA\u2013LDA modeling was able to extract the significant Raman peaks of gastric tissues (PC5 \u2013 0.007%, PC10 \u2013 0.004%, PC11 \u2013 0.003%) resolving highly specific biomolecular information of proteins, DNA and lipids (e.g., at 853, 1004, 1078, 1302, 1335, 1440, 1618, 1655 and 1745 cm \u22121 ) for tissue diagnosis ( Huang et al., 2010a; Bergholt et al., 2010a ) ( Fig. 4 ). The comprehensive biochemical/biomolecular basis of in vivo Raman spectroscopic diagnosis of gastric cancer has been discussed elsewhere ( Huang et al., 2010a,b; Bergholt et al., 2010a,b; Bergholt et al., 2011b ). Briefly, the peaks at 1575 cm \u22121 (C C bending of pyrimidine ring of nucleic acids) and 1335 cm \u22121 are highly related to abnormal DNA content ( Huang et al., 2010b; Mahadevan-Jansen and Richards-Kortum, 1996; Bergholt et al., 2010a ) whereas the increased peak of the 1655 cm \u22121 Amide I \u03bd (C O) vibration suggests a higher content of \u03b1-helical proteins (e.g., histones, the main protein component that makes up the chromatin) ( Bergholt et al., 2010a ). Overall, these specific biomolecular changes relate with increased nuclear activity (e.g., hyperchromatic state), which is among the main characteristics of tissue carcinogenesis process and is of substantial clinical and pathological values. Furthermore, the decrease at 853 cm \u22121 (proline) associated with neoplasia reconfirms the increased epithelial proliferation or light re-absorption associated with neovasculation obscuring collagen signals originating from the lamina propria layer ( Mayinger et al., 2004; Huang et al., 2010b; Bergholt et al., 2010a; Shao et al., 2010 ). The variation increase/decrease in signals from proteins 936, 1004, 1265, 1445 and 1655 cm \u22121 of PC5 could also be linked to increased mitotic activity (e.g., enzymes, hormones, etc.) ( Huang et al., 2010a; Short et al., 2005 ). The lipid signals (1078, 1302, 1440 and 1745 cm \u22121 ) have also been found diagnostically significant in our previous Raman studies ( Teh et al., 2008a; Teh et al., 2008b; Huang et al., 2010b; Bergholt et al., 2010a ). Thus, Raman spectroscopy provides a very specific molecular fingerprint of tissue pathology, facilitating in vivo tissue diagnostics and characterization in the gastric at the molecular level. To evaluate how NIR AF and Raman signals co-contribute to the diagnostic performance, the PC1 component essentially representing the NIR AF signal was evaluated, providing the diagnostic accuracy of 86.3% (sensitivity of 98.6% (138/140) and specificity of 84.7% (930/1098)), which is slightly less accurate than the Raman model (PC5, PC10, PC11) with an accuracy of 89.7% (sensitivity of 92.9% (130/140) and specificity of 89.3% (980/1098)). But the combined Raman and NIR AF model (PC1, PC5, PC10, PC11) achieved the highest diagnostic accuracy of 92.2% (sensitivity of 97.9% (137/140) and specificity of 91.5% (1005/1098)). Hence, the developed integrated NIR AF/Raman-PCA model can provide new insights into the underlying spectroscopic processes (i.e., NIR AF and Raman), which are complimentary for tissue diagnosis and characterization ( Huang et al., 2005 ). The ROC curves in Fig. 6 further confirm that combining NIR AF and Raman spectroscopy provides the most robust diagnostic model (AUC = 0.985) for in vivo gastric cancer diagnosis as compared to NIR AF and Raman alone. Under the 785 nm laser excitation, the in vivo tissue Raman spectra are born with endogenous autofluorescence signatures providing the unique opportunity to utilize both the biomolecular structure and composition of the tissue (Raman), as well as the fluorophores and morphological architectures of tissue (NIR AF) for enhancing in vivo gastric tissue diagnosis and characterization. We anticipate that the development of a NIR AF wide-field imaging modality with high contrast ( Fig. 2 ) could provide a novel means for identifying suspicious lesions in the stomach. Once identified, point-wise NIR AF and Raman spectroscopy could probe the specific fluorophores and biomolecular compositions of the suspicious lesions for more effective gastric cancer diagnosis. NIR AF wide-field imaging could comprise several major advantages over conventional UV/visible autofluorescence imaging, such as much deeper tissue light penetration (\u223c1 mm) without mutagenic effects, and therefore has potential to facilitate the in vivo interrogation of stromal tumors with high contrast and to guide endoscopic therapies (e.g., endoscopic submucosal dissection, etc.). 5 Conclusion This study discloses the diagnostic capability of NIR AF spectroscopy for in vivo gastric cancer diagnosis with good diagnostic accuracy. The composite in vivo NIR AF spectroscopy and Raman spectroscopy are further established as being complementary optical techniques for the enhanced tissue diagnosis. Therefore, the integrated Raman and NIR AF endoscopy holds a great promise for improving the in vivo detection and diagnosis of early gastric cancer during clinical gastroscopic examinations. 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        "keywords": [
            "near infrared",
            "raman spectra",
            "raman spectroscopy",
            "receiver operator characteristic",
            "principal component analysis",
            "roc curve"
        ],
        "authors": [
            {
                "name": "Mads Sylvest Bergholt",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore"
            },
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore"
            },
            {
                "name": "Khek Yu Ho",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital, Singapore 119260, Singapore"
            },
            {
                "name": "Ming Teh",
                "org": "Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital, Singapore 119074, Singapore"
            },
            {
                "name": "Khay Guan Yeoh",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital, Singapore 119260, Singapore"
            },
            {
                "name": "Jimmy Bok Yan So",
                "org": "Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital, Singapore 119074, Singapore"
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Biosensors and Bioelectronics",
        "year": 2011
    },
    "LXwgvJbR": {
        "id": "LXwgvJbR",
        "title": "Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy improves in vivo diagnosis of esophageal squamous cell carcinoma at endoscopy.",
        "abstract": "Simultaneous fingerprint and high-wavenumber fiber-optic Raman spectroscopy improves                 in vivo  diagnosis of esophageal squamous cell carcinoma at endoscopy",
        "keywords": [],
        "authors": [
            {
                "name": "jianfeng wang",
                "org": ""
            },
            {
                "name": "kan lin",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "khek yu ho",
                "org": ""
            },
            {
                "name": "ming teh",
                "org": ""
            },
            {
                "name": "khay guan yeoh",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Scientific Reports",
        "year": 2015
    },
    "QNyLONLB": {
        "id": "QNyLONLB",
        "title": "Near-infrared fluorescence imaging for colonic cancer detection",
        "abstract": "",
        "keywords": [
            "luminescence",
            "near infrared",
            "cancer",
            "reflectivity",
            "medical diagnostics"
        ],
        "authors": [
            {
                "name": "xiaozhuo shao",
                "org": "national university of singapore"
            },
            {
                "name": "jianhua mo",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "z1QRtnHm": {
        "id": "z1QRtnHm",
        "title": "Sa2035 Fiber-Optic Raman Spectroscopy for Label-Free In Vivo Molecular Diagnostics of Gastrointestinal Neoplasia at Endoscopy",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Jianfeng Wang",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay G. Yeoh",
                "org": ""
            },
            {
                "name": "Jimmy So",
                "org": ""
            },
            {
                "name": "Asim Shabbir",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2016
    },
    "8GvXZouV": {
        "id": "8GvXZouV",
        "title": "Multicolor excitation two-photon microscopy: in vivo imaging of cells and tissues",
        "abstract": "",
        "keywords": [
            "in vivo imaging",
            "biological systems",
            "two photon microscopy",
            "photonic crystal fiber",
            "femtosecond laser",
            "fine structure",
            "luminescence",
            "nonlinear optics",
            "microscopy",
            "cancer",
            "photonic crystal fibers"
        ],
        "authors": [
            {
                "name": "dong li",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "Bios",
        "year": 2010
    },
    "5xXnpaTY": {
        "id": "5xXnpaTY",
        "title": "DIAGNOSTIC INSTRUMENT AND METHODS RELATING TO RAMAN SPECTROSCOPY",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "mads sylvest bergholt",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
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                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "MNbbT4BM": {
        "id": "MNbbT4BM",
        "title": "Two-photon excited hemoglobin fluorescence.",
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        "keywords": [
            "time-resolved",
            "multiphoton",
            "(300.6410) spectroscopy",
            "(170.0170) medical optics and biotechnology",
            "(170.2520) fluorescence microscopy",
            "(180.4315) nonlinear microscopy",
            "(300.6500) spectroscopy",
            "biomedical research",
            "bioinformatics",
            "fluorescence microscopy"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Dong Li",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yan Zeng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yi Luo",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            }
        ],
        "venue": "Biomedical optics express",
        "year": 2010
    },
    "drMlWnoW": {
        "id": "drMlWnoW",
        "title": "Abstract 1165: Image-guided Raman endoscopy for in vivo clinical detection of cancer in the stomach",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "feng zhu",
                "org": ""
            },
            {
                "name": "jimmy bok yan so",
                "org": ""
            },
            {
                "name": "khay guan yeoh",
                "org": ""
            },
            {
                "name": "ming teh",
                "org": ""
            },
            {
                "name": "khek yu ho",
                "org": ""
            },
            {
                "name": "seng khoon teh",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2010
    },
    "Pl4XqN54": {
        "id": "Pl4XqN54",
        "title": "Polarization-resolved hyperspectral stimulated Raman scattering microscopy for label-free biomolecular imaging of the tooth",
        "abstract": "We report the development and implementation of a rapid polarization-resolved hyperspectral stimulated Raman scattering (SRS) microscopy technique for label-free biomolecular imaging of the tooth. The hyperspectral SRS imaging technique developed covers both fingerprint (800\u20131800\u2009cm\u22121) and high-wavenumber (2800\u20133600\u2009cm\u22121) regions for tooth Raman imaging without fluorescence background interference with an imaging speed of  106 faster than confocal Raman imaging. Significant differences of hyperspectral SRS spectra among different tooth locations (e.g., dentin, enamel, and dentin-enamel junction) are observed, revealing the biochemical distribution differences across the tooth. Further polarization-resolved SRS imaging shows different polarization dependences related to the molecular orientation differences of various tooth locations. This work demonstrates the potential of polarization-resolved hyperspectral SRS imaging technique developed i...",
        "keywords": "",
        "authors": [
            {
                "name": "Zi Wang",
                "org": "OpticalBioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Wei Zheng",
                "org": "OpticalBioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "C.-Y.S. Hsu",
                "org": "Department of Preventive Dentistry, Faculty of Dentistry, National University of Singapore and National University Health System, Singapore 119083"
            },
            {
                "name": "Zhiwei Huang",
                "org": "OpticalBioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            }
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        "year": 2016
    },
    "uF34EaUW": {
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        "abstract": "",
        "keywords": [],
        "authors": [
            {
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                "org": ""
            },
            {
                "name": "kan lin",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "hongzhi xu",
                "org": ""
            },
            {
                "name": "qingwen huang",
                "org": ""
            },
            {
                "name": "jianlin ren",
                "org": ""
            },
            {
                "name": "khekyu ho",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2014
    },
    "G96DWNI0": {
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        "title": "Elliptically polarized coherent anti-Stokes Raman scattering microscopy.",
        "abstract": "We report an approach to coherent anti-Stokes Raman scattering (CARS) microscopy that significantly suppresses the nonresonant background for high-contrast vibrational imaging. We employ an elliptically polarized pump field with an aspect ratio of 1:3 of the ellipse combined with a linearly polarized Stokes field for elliptically polarized CARS (EP-CARS) microscopy. The EP-CARS technique yields a 6-7-fold improvement in signal-to-background ratios compared with normal CARS, while providing an approximately 1.25-fold improvement in resonant CARS signal compared with normal polarization-sensitive CARS microscopy. We demonstrate this technique by imaging 1.5 microm polystyrene beads in water and lipid droplets in unstained fibroblast cells.",
        "keywords": [
            "aspect ratio",
            "microscopy",
            "oscillations",
            "biomedical imaging"
        ],
        "authors": [
            {
                "name": "Fake Lu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
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        "venue": "Optics letters",
        "year": 2008
    },
    "YPPTqQ7z": {
        "id": "YPPTqQ7z",
        "title": "Interferometric polarization coherent anti-Stokes Raman scattering (IP-CARS) microscopy.",
        "abstract": "We report a novel interferometry-based polarization coherent anti-Stokes Raman scattering (IP-CARS) implementation for effectively suppressing the nonresonant background while significantly amplifying the resonant signal for vibrational imaging. By modulating the phase difference between the two interference CARS signals generated from the same sample and measuring the peak-to-peak intensity of the periodically modulated interference CARS signal, the IP-CARS technique yields a sixfold improvement in the signal-to-background ratio compared with conventional CARS while providing an approximately 20-fold amplification of the resonant CARS signal compared with conventional polarization CARS. We demonstrate this method by imaging 4.69 microm polystyrene beads and unstained human epithelial cells immersed in water.",
        "keywords": [
            "interference microscopy",
            "microscopy"
        ],
        "authors": [
            {
                "name": "Fake Lu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Colin Sheppard",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
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        "year": 2008
    },
    "lCBn5yy4": {
        "id": "lCBn5yy4",
        "title": "Combining near-infrared autofluorescence and Raman spectroscopy improves the in vivo detection of cervical precancer",
        "abstract": "",
        "keywords": [
            "in vivo",
            "raman spectroscopy",
            "fluorescence spectroscopy",
            "near infrared",
            "optical scattering",
            "spectroscopy",
            "infrared spectroscopy",
            "cancer",
            "raman scattering",
            "polynomials"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "jianhua mo",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "jeffrey low",
                "org": ""
            },
            {
                "name": "joseph ng",
                "org": ""
            },
            {
                "name": "a ilancheran",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2008
    },
    "KE1DeM4f": {
        "id": "KE1DeM4f",
        "title": "Novel coherent anti-stokes Raman scattering microscopy for high contrast bioimaging",
        "abstract": "",
        "keywords": [
            "signal strength",
            "polarization",
            "microscopy",
            "water",
            "heterodyning"
        ],
        "authors": [
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "paXIcsU8": {
        "id": "paXIcsU8",
        "title": "Aqueous phase synthesis of widely tunable photoluminescence emission CdTe/CdS core/shell quantum dots under a totally ambient atmosphere",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mengqiao dai",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "linyue lanry yung",
                "org": "national university of singapore"
            }
        ],
        "venue": "Journal of Materials Chemistry",
        "year": 2012
    },
    "O31fyZmr": {
        "id": "O31fyZmr",
        "title": "Two-photon microscopy of living cells by simultaneously exciting multiple endogenous fluorophores and fluorescent proteins",
        "abstract": "",
        "keywords": [
            "endoplasmic reticulum",
            "microscopy",
            "genetics",
            "green fluorescent protein",
            "molecules",
            "femtosecond laser",
            "photonic crystal fiber",
            "photons",
            "photonic crystal fibers",
            "luminescence",
            "two photon microscopy"
        ],
        "authors": [
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "dong li",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "Bios",
        "year": 2010
    },
    "B3uefE9v": {
        "id": "B3uefE9v",
        "title": "Full-field optical coherence tomography for rapid 3-D imaging in biological systems",
        "abstract": "",
        "keywords": [
            "geometric phase",
            "image restoration",
            "optical path difference",
            "biological systems",
            "3d imaging",
            "phase shift",
            "phase shifting",
            "image reconstruction",
            "stereoscopy"
        ],
        "authors": [
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "colin j r sheppard",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "wv98xpwm": {
        "id": "wv98xpwm",
        "title": "Sensing cell metabolism by time-resolved autofluorescence.",
        "abstract": "We built a time-resolved confocal fluorescence spectroscopy system equipped with the multichannel time-correlated single-photon-counting technique. The instrument provides a unique approach to study the fluorescence sensing of cell metabolism via analysis of the wavelength- and time-resolved intracellular autofluorescence. The experiments on monolayered cell cultures show that with UV excitation at 365 nm the time-resolved autofluorescence decays, dominated by free-bound reduced nicotinamide adenine dinucleotide signals, are sensitive indicators for cell metabolism. However, the sensitivity decreases with the increase of excitation wavelength possibly due to the interference from free-bound flavin adenine dinucleotide fluorescence. The results demonstrate that time-resolved autofluorescence can be potentially used as an important contrast mechanism to detect epithelial precancer.",
        "keywords": [
            "cell culture",
            "fluorescence spectroscopy"
        ],
        "authors": [
            {
                "name": "Yicong Wu",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            }
        ],
        "venue": "Optics letters",
        "year": 2006
    },
    "Z20UfnK1": {
        "id": "Z20UfnK1",
        "title": "Quantitative fiber-optic Raman spectroscopy for tissue Raman measurements",
        "abstract": "",
        "keywords": [
            "lasers",
            "lenses",
            "cancer",
            "raman spectroscopy",
            "quantitative analysis",
            "fiber optics"
        ],
        "authors": [
            {
                "name": "shiyamala duraipandian",
                "org": "national university of singapore"
            },
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "FV1d1bev": {
        "id": "FV1d1bev",
        "title": "Radially polarized tip-enhanced near-field coherent anti-Stokes Raman scattering microscopy for vibrational nano-imaging",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jian lin",
                "org": ""
            },
            {
                "name": "kenneth zi jian er",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2013
    },
    "KQLR66hb": {
        "id": "KQLR66hb",
        "title": "Heterodyne Polarization Coherent Anti-Stokes Raman Scattering (HP-CARS) Microscopy for High Contrast Bioimaging",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "fake lu",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Biomedical Engineering",
        "year": 2008
    },
    "NmWJsghW": {
        "id": "NmWJsghW",
        "title": "Mo1647 Confocal Raman Spectroscopy for Real-Time In Vivo Detection of High-grade Dysplasia in Barrett's Esophagus During Endoscopic Examination",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "khekyu ho",
                "org": ""
            },
            {
                "name": "ming teh",
                "org": ""
            },
            {
                "name": "jimmy b so",
                "org": ""
            },
            {
                "name": "asim shabbir",
                "org": ""
            },
            {
                "name": "khay guan yeoh",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Gastrointestinal Endoscopy",
        "year": 2013
    },
    "ICaPO2B3": {
        "id": "ICaPO2B3",
        "title": "Development of a hybrid Raman spectroscopy and optical coherence tomography technique for real-time in vivo tissue measurements.",
        "abstract": "We report on the development of a unique sideview handheld hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique for real-time in vivo tissue measurements. A sideview handheld RS-OCT optical probe is designed to coalign the optical paths of RS and OCT sampling arms, whereby a compact long-pass dichroic mirror (LPDM) is utilized to transmit the OCT signal through a gradient index rod lens and a reflection mirror, whereas the LPDM deflects the tissue Raman signal by 90\u00b0, leading to coaligned RS/OCT optical samplings on the tissue. Further study shows that the hybrid RS and OCT technique developed is capable of simultaneously acquiring both morphological and biochemical information about the oral tissue in vivo, facilitating real-time, in vivo tissue diagnoses and characterizations in the oral cavity. ",
        "keywords": "",
        "authors": [
            {
                "name": "Jianfeng Wang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore"
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Singapore"
            }
        ],
        "venue": "Optics letters",
        "year": 2016
    },
    "IzP6dKuy": {
        "id": "IzP6dKuy",
        "title": "Saliva analysis using surface-enhanced Raman spectroscopy technique",
        "abstract": "",
        "keywords": [
            "nanostructures",
            "gold",
            "metals",
            "polymers",
            "raman scattering"
        ],
        "authors": [
            {
                "name": "clement yuen",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "tbVxo5An": {
        "id": "tbVxo5An",
        "title": "A novel broadband Raman endoscopy for in vivo diagnosis of intestinal metaplasia in the stomach",
        "abstract": "",
        "keywords": [
            "medical diagnostics",
            "fiber optics",
            "raman spectroscopy",
            "fingerprint recognition"
        ],
        "authors": [
            {
                "name": "kan lin",
                "org": "national university of singapore"
            },
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "jianfeng wang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "hongzhi xu",
                "org": ""
            },
            {
                "name": "jianlin ren",
                "org": ""
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "ye3bx8Wj": {
        "id": "ye3bx8Wj",
        "title": "Endoscope-based beveled and volume fiber-optic Raman probes for in vivo diagnosis of gastric dysplasia: a comparative study",
        "abstract": "Raman spectroscopy is a unique optical vibrational spectroscopic technique which is capable of probing biochemical and biomolecular structures and conformations associated with disease transformation. Raman probe is a key component to facilitate the in vivo tissue diagnosis by using Raman spectroscopy. The diagnostic performance of the two different endoscope-based fiber-optic Raman probe designs (i.e., beveled and volume Raman probes) were evaluated for real-time, in vivo diagnosis of gastric dysplasia at endoscopy. The beveled Raman probe provides approximately 2-fold improvements in tissue Raman to autofluorescence intensity ratios as compared to the use of volume Raman probe. The diagnostic accuracy of gastric dysplasia using beveled Raman probe is 93.0% (sensitivity of 92.5%; specificity of 93.1%), which is superior to the diagnostic performance (accuracy of 88.4%; sensitivity of 85.8%; specificity of 88.6%) using the volume Raman probe. Biomolecular modeling is finally employed to extract the different Raman active components interrogated by the two types of endoscope-based Raman probes.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianfeng Wang",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Kan Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Khek Yu Ho",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Ming Teh",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Khay Guan Yeoh",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "OcF6djBY": {
        "id": "OcF6djBY",
        "title": "Saturated Stimulated-Raman-Scattering Microscopy for Far-Field Superresolution Vibrational Imaging",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Li Gong",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Ying Ma",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Physical review applied",
        "year": 2019
    },
    "k7hTGl2w": {
        "id": "k7hTGl2w",
        "title": "Optimization of extinction efficiency of gold-coated polystyrene bead substrates improves surface-enhanced Raman scattering effects by post-growth microwave heating treatment",
        "abstract": "",
        "keywords": [
            "discrete dipole approximation",
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "Clement Yuen",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Journal of Raman Spectroscopy",
        "year": 2009
    },
    "TIhGDaTh": {
        "id": "TIhGDaTh",
        "title": "Epi-detected quadruple-modal nonlinear optical microscopy for label-free imaging of the tooth",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zi wang",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "chinying stephen hsu",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2015
    },
    "owXHz3v8": {
        "id": "owXHz3v8",
        "title": "Classification of Raman Spectra of Colonic Tissues using Pattern Recognition Technique",
        "abstract": "",
        "keywords": [
            "fluorescence",
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "effendi widjaja",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "jianhua mo",
                "org": ""
            },
            {
                "name": "colin j r sheppard",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2006
    },
    "rTfopfOb": {
        "id": "rTfopfOb",
        "title": "Image-Guided Raman Endoscopic Probe for In Vivo Early Detection of High Grade Dysplasia",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Seng Khoon Teh",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Gastrointestinal Endoscopy",
        "year": 2009
    },
    "GIyG2bF9": {
        "id": "GIyG2bF9",
        "title": "Characterizing variability in in vivo Raman spectroscopic properties of different anatomical sites of normal tissue in the oral cavity",
        "abstract": "",
        "keywords": [
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Journal of Raman Spectroscopy",
        "year": 2012
    },
    "9Xd6XWKk": {
        "id": "9Xd6XWKk",
        "title": "Simultaneous quadruple modal nonlinear optical imaging for gastric diseases diagnosis and characterization",
        "abstract": "",
        "keywords": [
            "optical microscopy",
            "optical imaging",
            "medical diagnostics",
            "raman scattering",
            "luminescence",
            "photons",
            "second harmonic generation"
        ],
        "authors": [
            {
                "name": "zi wang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "4nUJqWtS": {
        "id": "4nUJqWtS",
        "title": "Quantitative assessment of spinal cord injury using circularly polarized coherent anti-Stokes Raman scattering microscopy",
        "abstract": "We report the quantitative assessment of spinal cord injury using the circularly polarized coherent anti-Stokes Raman scattering (CP-CARS) technique together with Stokes parameters in the Poincare sphere. The pump and Stokes excitation beams are circularly polarized to suppress both the linear polarization-dependent artifacts and the nonresonant background of tissue CARS imaging, enabling quantitative CP-CARS image analysis. This study shows that CP-CARS imaging uncovers significantly increased phase retardance of injured spinal cord tissue as compared to normal tissue, suggesting that CP-CARS is an appealing label-free imaging tool for determining the degree of tissue phase retardance, which could serve as a unique diagnostic parameter associated with nervous tissue injury.",
        "keywords": "",
        "authors": [
            {
                "name": "Kideog Bae",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2017
    },
    "wquz0uS0": {
        "id": "wquz0uS0",
        "title": "Two-photon autofluorescence microscopy of multicolor excitation.",
        "abstract": "We developed a two-photon autofluorescence lifetime imaging system with excitations selected from the supercontinuum generated from a photonic crystal fiber. The system excites multiple endogenous fluorophores, such as nicotinamide adenine dinucleotide (NADH) and tryptophan, simultaneously and produces coregistered two-photon autofluorescence images of a biological sample. The technology provides a unique approach to investigate the cellular metabolic activity and protein expression in cells that are potentially important for noninvasive precancer diagnostics. We demonstrated that by taking the tryptophan fluorescence as a reference the ratio of NADH to the tryptophan signal serves as a sensitive indicator of cellular metabolism. The ratio can also clearly differentiate normal cells from cancer cells. The tryptophan fluorescence lifetime images of cells shows that the lifetime of tryptophan fluorescence, varying over a wide range, may be highly dependent on the expression and structure of the protein that tryptophan is packed in.",
        "keywords": [
            "photonic crystal fiber",
            "fluorescence lifetime imaging",
            "protein expression"
        ],
        "authors": [
            {
                "name": "Dong Li",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            }
        ],
        "venue": "Optics letters",
        "year": 2009
    },
    "mNFNhC1q": {
        "id": "mNFNhC1q",
        "title": "Novel fiber optic-probe design for depth-resolved fluorescence measurements: Monte Carlo simulations",
        "abstract": "",
        "keywords": [
            "fluorescence spectroscopy",
            "fiber optic",
            "monte carlo simulation"
        ],
        "authors": [
            {
                "name": "franck jaillon",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "xingde li",
                "org": ""
            },
            {
                "name": "qingming luo",
                "org": ""
            },
            {
                "name": "ying gu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2007
    },
    "qzxdrTDF": {
        "id": "qzxdrTDF",
        "title": "Monitoring changes of cellular metabolism and microviscosity in vitro based on time-resolved endogenous fluorescence and its anisotropy decay dynamics.",
        "abstract": "Reduced nicotinamide adenine dinucleotide (NADH) is a well-known metabolic coenzyme and endogenous fluorophore. In this study, we develop a system that simultaneously measures time- and wavelength-resolved fluorescence to extract free and protein-bound NADH signals from total cellular fluorescence. We analyze temporal characteristics of NADH fluorescence in a mixture of NADH and lactate dehydrogenase (LDH) as well as in living cell samples. The results show that in both the NADH/LDH mixture and cell samples, a fraction of free NADH and protein-bound components can be identified. The extracted free and bound NADH signals are confirmed by time-resolved measurement of anisotropy decay of NADH fluorescence, based on the fact that free NADH is a small fluorescent molecule with much shorter rotational diffusion time than bound NADH. The ratio of free NADH signal to bound NADH signal is very different between normal and cancer cervical epithelial cells. In addition, the ratio changes significantly when the cell samples are treated with a mitochondrial inhibitor or uncoupler, demonstrating that the method is sensitive to monitor cellular metabolic activity. Finally, we demonstrate that the microviscosity for relatively small molecules such as NADH in cells could be extracted from wavelength- and time-resolved NADH fluorescence of living cell samples.",
        "keywords": [
            "luminescence",
            "kinetics",
            "enzyme",
            "fluorescence anisotropy",
            "epithelial cell"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Dong Li",
                "org": ""
            },
            {
                "name": "Jianan Y. Qu",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2010
    },
    "GKLjaLUt": {
        "id": "GKLjaLUt",
        "title": "Moving Raman spectroscopy into real-time, online diagnosis and detection of precancer and cancer in vivo in the upper GI during clinical endoscopic examination",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "medical diagnostics",
            "cancer"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "jimmy bok yan so",
                "org": "national university of singapore"
            },
            {
                "name": "asim shabbir",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2013
    },
    "abfbVz4W": {
        "id": "abfbVz4W",
        "title": "Phase-controlled polarization coherent anti-Stokes Raman scattering microscopy for high-sensitivity and high-contrast molecular imaging",
        "abstract": "We report on a phase-controlled polarization coherent anti-Stokes Raman scattering (CARS) microscopy for high-sensitivity and high-contrast molecule vibrational imaging. By changing the phase difference between the two CARS signals (i.e., a weak resonant CARS and a strong nonresonant CARS signal) simultaneously gen- erated from the same focal volume of the sample, the complete constructive (in-phase) and destructive (out-of- phase) interference CARS images can be acquired for image processing. The directly digital subtraction be- tween the constructive and destructive interference CARS images yields a fivefold improvement in signal-to- background ratios compared with conventional CARS while providing an approximately 20-fold amplification of a resonant CARS signal compared with conventional polarization CARS imaging. We demonstrate this tech- nique by imaging 1 m polystyrene beads and unstained human epithelial cells in aqueous environments. \u00a9 2008 Optical Society of America OCIS codes: 100.3175, 110.0180, 180.6900, 190.3970, 190.4380, 300.6230.",
        "keywords": [
            "image processing",
            "epithelial cell",
            "microscopy",
            "molecular imaging"
        ],
        "authors": [
            {
                "name": "Fake Lu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Journal of The Optical Society of America B-optical Physics",
        "year": 2008
    },
    "WbBKw25K": {
        "id": "WbBKw25K",
        "title": "Coherent anti-Stokes Raman scattering microscopy for sensing molecular orientations",
        "abstract": "We report a radially polarized coherent anti-Stokes Raman scattering (CARS) microscopy to facilitate longitudinally oriented molecules detection. We demonstrate that combining both the radially and linearly polarized excitation schemes, CARS microscopy can be a very powerful tool for identifying the 3-D orientations of molecules with high sensitivity and chemical specificity.",
        "keywords": [],
        "authors": [
            {
                "name": "Lu, Fake",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576|c|"
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Communications and Photonics Conference and Exhibition",
        "year": 2009
    },
    "sCyAgkNC": {
        "id": "sCyAgkNC",
        "title": "Multimodal nonlinear optical microscopy for label-free imaging of liver tissue",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "zi wang",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "jian lin",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "EPQigw0b": {
        "id": "EPQigw0b",
        "title": "SURFACE-ENHANCED RAMAN SCATTERING: PRINCIPLES, NANOSTRUCTURES, FABRICATIONS, AND BIOMEDICAL APPLICATIONS",
        "abstract": "",
        "keywords": [
            "surface plasmon",
            "nanotechnology"
        ],
        "authors": [
            {
                "name": "CLEMENT YUEN",
                "org": ""
            },
            {
                "name": "WEI ZHENG",
                "org": ""
            },
            {
                "name": "ZHIWEI HUANG",
                "org": ""
            }
        ],
        "venue": "Journal of Innovative Optical Health Sciences",
        "year": 2008
    },
    "ZMYY9dQD": {
        "id": "ZMYY9dQD",
        "title": "Multivariate Reference Technique for Quantitative Analysis of Fiber-Optic Tissue Raman Spectroscopy",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shiyamala duraipandian",
                "org": ""
            },
            {
                "name": "mads sylvest bergholt",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Analytical Chemistry",
        "year": 2013
    },
    "s4O4FysN": {
        "id": "s4O4FysN",
        "title": "Near-infrared Raman spectroscopy for optical diagnosis in the stomach: Identification of Helicobacter-pylori infection and intestinal metaplasia",
        "abstract": "Raman spectroscopy is a unique vibrational spectroscopic technique which can be used to probe biochemicals and biomolecular structures and conformations of tissues. The main objective of this study is to evaluate the feasibility of applying near-infrared (NIR) Raman spectroscopy for identification of nonneoplastic lesions (Helicobacter-pylori (Hp) infection, and intestinal metaplasia (IM)) highly associated with stomach cancer. A rapid-acquisition NIR Raman spectroscopic system was used for tissue Raman measurements at 785 nm excitation, and a total of 88 gastric tissue samples (57 normal; 11 Hp-infection; 20 IM) from 56 patients were measured. The principal components analysis (PCA) and linear discriminant analysis (LDA) techniques were implemented to develop effective diagnostic algorithms for classification of Raman spectra of different gastric tissue types. High-quality Raman spectra in the range of 800-1800 cm 21 were acquired from gastric tissue within 5 seconds. Significant spectral differences in Raman spectra were observed among normal, Hp-infection and IM gastric tissue, particularly in the spectral ranges of 848-917, 960-1015, 1088-1133, 1206-1213, 1277-1313, 1395-1445, 1517- 1549, 1607-1690, and 1714-1767 cm 21 which contained signals related to proteins, lipids and porphyrin. PCA-LDA algorithms developed together with leave-one-patient-out, cross validation technique yield diagnostic sensitivities of 91.7%, 80.0%, and 80.0%, and specificities of 80.0%, 100%, and 92.7%, respectively, for classification of normal, Hp-infection and IM gastric tissues. This work demonstrates the utility of NIR Raman spectroscopy for early diagnosis of Hp-infection and IM lesions in the gastric at the molecular level.",
        "keywords": [
            "principal components analysis",
            "intestinal metaplasia",
            "linear discriminant analysis",
            "stomach",
            "near-infrared raman spectroscopy",
            "helicobacter-pylori infection",
            "principal component analysis",
            "cross validation",
            "near infrared",
            "raman spectra",
            "raman spectroscopy",
            "diagnosis",
            "histopathology",
            "near infrared spectroscopy"
        ],
        "authors": [
            {
                "name": "Seng Khoon Teh",
                "org": "Optical Bioimaging Laboratory|Department of Bioengineering|Faculty of Engineering|National University of Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory|Department of Bioengineering|Faculty of Engineering|National University of Singapore"
            },
            {
                "name": "Khek Yu Ho",
                "org": "Department of Medicine|Yong Loo Lin|School of Medicine|National University of Singapore|National University Hospital"
            },
            {
                "name": "Ming Teh",
                "org": "Department of Pathology|Yong Loo Lin School of Medicine|National University of Singapore|National University Hospital"
            },
            {
                "name": "Khay Guan Yeoh",
                "org": "Department of Medicine|Yong Loo Lin|School of Medicine|National University of Singapore|National University Hospital"
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory|Department of Bioengineering|Faculty of Engineering|National University of Singapore"
            }
        ],
        "venue": "International Journal of Cancer",
        "year": 2009
    },
    "lEWzVDwP": {
        "id": "lEWzVDwP",
        "title": "Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence.",
        "abstract": "A time-resolved spectroscopic imaging system is built to study the fluorescence characteristics of nicotinamide adenine dinucleotide (NADH), an important metabolic coenzyme and endogenous fluorophore in cells. The system provides a unique approach to measure fluorescence signals in different cellular organelles and cytoplasm. The ratios of free over protein-bound NADH signals in cytosol and nucleus are slightly higher than those in mitochondria. The mitochondrial fluorescence contributes about 70% of overall cellular fluorescence and is not a completely dominant signal. Furthermore, NADH signals in mitochondria, cytosol, and the nucleus respond to the changes of cellular activity differently, suggesting that cytosolic and nuclear fluorescence may complicate the well-known relationship between mitochondrial fluorescence and cellular metabolism.",
        "keywords": [],
        "authors": [
            {
                "name": "Dong Li",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            }
        ],
        "venue": "Optics letters",
        "year": 2008
    },
    "FZDYcgeQ": {
        "id": "FZDYcgeQ",
        "title": "Time-resolved detection enables standard two-photon fluorescence microscopy for in vivo label-free imaging of microvasculature in tissue.",
        "abstract": "We conducted a systematic study on two-photon excited fluorescence (TPEF) of hemoglobin using the near transform-limited and Gaussian-shaped femtosecond pulse sources. We found that the two-photon action cross section of hemoglobin drops over 2 orders of magnitude in the wavelength range from 550 to 800 nm, while the spectral and temporal characteristics of hemoglobin TPEF are insensitive to the change of excitation wavelength. In particular, our new findings showed that the hemoglobin fluorescence could be excited with sufficient efficiency using a conventional Ti:sapphire laser tuned at the wavelength close to 700 nm. With the employment of a time-resolved detection method, we demonstrated that the TPEF signals of hemoglobin excited by a Ti:sapphire laser could be clearly differentiated from other nonlinear signals presented within the living biological tissues, indicating that a standard TPEF microscope can become a routine tool for in vivo label-free microangiography imaging.",
        "keywords": [],
        "authors": [
            {
                "name": "Dong Li",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Wei Zheng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Wei Zhang",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Seng Khoon The",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yan Zeng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yi Luo",
                "org": "University of Science and Technology of China(University of Science and Technology of China,Univ. of Sci. and Technol. of China),Hefei,China"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            }
        ],
        "venue": "Optics letters",
        "year": 2011
    },
    "pz3RqCbM": {
        "id": "pz3RqCbM",
        "title": "Improved contrast radially polarized coherent anti-Stokes Raman scattering microscopy using annular aperture detection",
        "abstract": "",
        "keywords": [
            "stimulated raman scattering",
            "finite difference time domain",
            "radiation pattern",
            "optical microscope",
            "optical microscopy",
            "raman scattering"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "haifeng wang",
                "org": "data storage institute"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "colin j sheppard",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2009
    },
    "pyjq2IFp": {
        "id": "pyjq2IFp",
        "title": "Integrated endoscopic imaging and point-wise spectroscopy for real-time in vivo tissue measurements",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kan lin",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "OmXhmDej": {
        "id": "OmXhmDej",
        "title": "T1851 Near-Infrared Raman Spectroscopy for Early Diagnosis of Helicobacter pylori-Associated Chronic Gastritis",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "near infrared"
        ],
        "authors": [
            {
                "name": "Seng Khoon Teh",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2008
    },
    "yTknKkYU": {
        "id": "yTknKkYU",
        "title": "Improving surface-enhanced Raman scattering effect using gold-coated hierarchical polystyrene bead substrates modified with postgrowth microwave treatment.",
        "abstract": "We report a novel postgrowth microwave heating implementation by selectively modifying hierarchical polystyrene (PS) bead substrates coated with gold (Au) films to effectively improve the surface-enhanced Raman scattering (SERS) effect on the analytes. The SERS signal of probe molecule rhodamine 6G (Rh 6G) on the microwave-treated Au-PS substrates can be improved by 10-fold, while the detection limit of Rh 6G in concentration can be enhanced by two orders of magnitude compared to the as-growth substrates. The high-quality SERS spectrum of saliva can also be acquired using the modified substrates, demonstrating the potential for the realization of the high-performance SERS substrates for biomedical applications.",
        "keywords": [
            "polystyrene bead",
            "saliva.",
            "surface-enhanced raman scattering",
            "raman spectroscopy",
            "spectrum",
            "raman scattering",
            "gold",
            "nanostructures",
            "detection limit"
        ],
        "authors": [
            {
                "name": "Clement Yuen",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2008
    },
    "8hRw7Mdd": {
        "id": "8hRw7Mdd",
        "title": "Near-infrared Raman spectroscopy for gastric precancer diagnosis",
        "abstract": "\ufffd 2009 John Wiley & Sons, Ltd.",
        "keywords": [
            "dysplasia",
            "optical diagnosis",
            "stomach",
            "precancer",
            "near-infrared raman spectroscopy",
            "raman spectroscopy",
            "near infrared"
        ],
        "authors": [
            {
                "name": "Seng Khoon Teh",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeohb",
                "org": ""
            },
            {
                "name": "Zhiwei Huanga",
                "org": ""
            }
        ],
        "venue": "Journal of Raman Spectroscopy",
        "year": 2009
    },
    "tad2S8mR": {
        "id": "tad2S8mR",
        "title": "Real time near-infrared Raman spectroscopy for the diagnosis of nasopharyngeal cancer.",
        "abstract": "Near-infrared (NIR) Raman spectroscopy has been investigated as a tool to differentiate nasopharyngeal cancer (NPC) from normal nasopharyngeal tissue in an ex-vivo setting. Recently, we have miniaturized the fiber-optic Raman probe to investigate its utility in real time in-vivo surveillance of NPC patients. A posterior probability model using partial linear square (PLS) mathematical technique was constructed to verify the sensitivity and specificity of Raman spectroscopy in diagnosing NPC from post-irradiated and normal tissue using a diagnostic algorithm from three significant latent variables. NIR-Raman signals of 135 sites were measured from 79 patients with either newly diagnosed NPC (N = 12), post irradiated nasopharynx (N = 37) and normal nasopharynx (N = 30). The mean Raman spectra peaks identified differences at several Raman peaks at 853 cm-1, 940 cm-1, 1078 cm-1, 1335 cm-1, 1554 cm-1, 2885 cm-1 and 2940 cm-1 in the three different nasopharyngeal conditions. The sensitivity and specificity of distinguishing Raman signatures among normal nasopharynx versus NPC and post-irradiated nasopharynx versus NPC were 91% and 95%; and 77% and 96% respectively. Real time near-infrared Raman spectroscopy has a high specificity in distinguishing malignant from normal nasopharyngeal tissue in vivo, and may be investigated as a novel non-invasive surveillance tool in patients with nasopharyngeal cancer.",
        "keywords": [
            "PLS-DA model",
            "Raman spectroscopy",
            "nasopharyngeal cancer",
            "real time imaging",
            "surveillance"
        ],
        "authors": [
            {
                "name": "Lim Chwee Ming",
                "org": "Division of Surgical Oncology, National Cancer Institute of Singapore, Singapore."
            },
            {
                "name": "Nagaraja Rao Gangodu",
                "org": "Department of Otolaryngology-Head and Neck Surgery, National University Health System, Singapore."
            },
            {
                "name": "Thomas Loh",
                "org": "Division of Surgical Oncology, National Cancer Institute of Singapore, Singapore."
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Jianfeng Wang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            },
            {
                "name": "Kan Lin",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore."
            },
            {
                "name": "Huang Zhiwei",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore."
            }
        ],
        "venue": "Oncotarget",
        "year": 2017
    },
    "rR5PlAy0": {
        "id": "rR5PlAy0",
        "title": "Assessment of fibrotic liver disease with multimodal nonlinear optical microscopy",
        "abstract": "",
        "keywords": [
            "nonlinear optics",
            "second harmonic generation",
            "matrices",
            "luminescence",
            "extracellular matrix proteins",
            "surgery",
            "microscopy",
            "optical microscopy",
            "photons"
        ],
        "authors": [
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "dean c s tai",
                "org": ""
            },
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "hanry yu",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Bios",
        "year": 2010
    },
    "TktPz22l": {
        "id": "TktPz22l",
        "title": "Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer.",
        "abstract": "During precancer development in epithelium, neoplastic cells remodel the underlying stroma, for example, the basement membrane, capillaries, fibroblasts, and extracellular matrix. The purpose of this study is to investigate the relationship between the nonlinear optical signals from the collagen matrix in stroma and the progression of early epithelial carcinogenesis. Two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) signals were measured from the stroma of hamster oral cheek pouch in vivo. We found that three features, including the intensity ratio of TPEF over SHG, the spatial frequency distribution, and the texture feature of SHG images, provide the quantitative identification of epithelial precancer at different pathologic stages. We demonstrated that the combination of all three features by using a support vector machine algorithm can significantly improve the accuracy in the detection of epithelial precancer.",
        "keywords": [
            "nonlinear optics"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Dong Li",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Shuxia Li",
                "org": "The University of Hong Kong(University of Hong Kong,The University of Hong Kong),Pokfulam,Hong Kong"
            },
            {
                "name": "Yan Zeng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yanqi Yang",
                "org": "The University of Hong Kong(University of Hong Kong,The University of Hong Kong),Pokfulam,Hong Kong"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            }
        ],
        "venue": "Optics letters",
        "year": 2011
    },
    "ehZs55hw": {
        "id": "ehZs55hw",
        "title": "Near-infrared autofluorescence spectroscopy for in vivo diagnosis of cervical precancer",
        "abstract": "",
        "keywords": [
            "luminescence",
            "principal component analysis",
            "spectroscopy",
            "nir spectroscopy",
            "near infrared",
            "lasers",
            "algorithms",
            "fiber optic",
            "multivariate statistics",
            "fiber optics",
            "medical diagnostics"
        ],
        "authors": [
            {
                "name": "jianhua mo",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "jeffrey low",
                "org": "national university of singapore"
            },
            {
                "name": "joseph ng",
                "org": "national university of singapore"
            },
            {
                "name": "a ilancheran",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "YWbesXAo": {
        "id": "YWbesXAo",
        "title": "Single-and two-photon excited autofluorescence of epithelial tissue",
        "abstract": "Single-and two-photon excited fluorescence spectra were measured at the same location in tissue. The results revealed that TPF and SPF signals are different and TPF signal provides more accurate information on tissue morphology. \u00a92007 Optical Society of America.",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Dong Li",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yicong Wu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            }
        ],
        "venue": "Biomedical Optics, BIOMED 2008",
        "year": 2008
    },
    "AU4NKa7t": {
        "id": "AU4NKa7t",
        "title": "Integrated coherent anti-Stokes Raman scattering and multiphoton microscopy for biomolecular imaging using spectral filtering of a femtosecond laser",
        "abstract": "",
        "keywords": [
            "stimulated raman scattering",
            "harmonic generation",
            "pulse compression",
            "higher order",
            "raman scattering",
            "second harmonic generation",
            "nonlinear optics",
            "optical filters",
            "spectral resolution",
            "multiphoton microscopy",
            "laser spectroscopy",
            "femtosecond laser"
        ],
        "authors": [
            {
                "name": "fake lu",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "jian lin",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2010
    },
    "zej9l0Rr": {
        "id": "zej9l0Rr",
        "title": "Coherent anti-Stokes Raman scattering microscopy using tightly focused radially polarized light.",
        "abstract": "We report a radially polarized coherent anti-Stokes Raman scattering (RP-CARS) microscopy for facilitating longitudinally oriented molecules detection. We observe that under tight focusing of radially polarized pump and Stokes light fields with a high-NA objective, RP-CARS radiation from molecules oriented along the longitudinal direction is approximately threefold stronger than that using linearly polarized CARS (LP-CARS) technique. The lateral resolution of RP-CARS imaging can be improved by about 10% compared to the LP-CARS imaging. We demonstrate this RP-CARS technique by imaging the sectioned cottonwood leaf vascular bundles.",
        "keywords": [
            "polarization",
            "microscopy",
            "polarized light"
        ],
        "authors": [
            {
                "name": "Fake Lu",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2009
    },
    "B1hyyhQE": {
        "id": "B1hyyhQE",
        "title": "Label-free multimodal nonlinear optical microscopy for in vivo diagnosis of precancerous squamous epithelia",
        "abstract": "We explore in vivo diagnostic utility of an in-house developed multimodal nonlinear optical microscopy for detection of squamous epithelia precancer. Our results reveal all epithelial sublayers and stroma provide significant diagnostic information. \u00a9 2012 Optical Society of America.",
        "keywords": [],
        "authors": [
            {
                "name": "Sengkhoon Teh",
                "org": "HKG(HKG),Hong Kong,China"
            },
            {
                "name": "Wei Zheng",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Shuxia Li",
                "org": "The University of Hong Kong(University of Hong Kong,The University of Hong Kong),Pokfulam,Hong Kong"
            },
            {
                "name": "Dong Li",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            },
            {
                "name": "Yan Zeng",
                "org": "The University of Hong Kong(University of Hong Kong,The University of Hong Kong),Pokfulam,Hong Kong"
            },
            {
                "name": "Yanqi Yang",
                "org": "The University of Hong Kong(University of Hong Kong,The University of Hong Kong),Pokfulam,Hong Kong"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Hong Kong University of Science and Technology(Hong Kong University of Science and Technology,Hong Kong Univ. of Sci. and Technol.),Hong Kong,China"
            }
        ],
        "venue": "Biomedical Optics, BIOMED 2012",
        "year": 2012
    },
    "qJhTd6sb": {
        "id": "qJhTd6sb",
        "title": "High contrast bioimaging using interferometric polarization coherent anti-Stokes Raman scattering microscopy",
        "abstract": "",
        "keywords": [
            "signal strength",
            "microscopy",
            "polarization",
            "water"
        ],
        "authors": [
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "Ra1fbOSW": {
        "id": "Ra1fbOSW",
        "title": "Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals.",
        "abstract": "We demonstrate an integrated optical microscope to image the living epithelial tissue by simultaneously exciting multiple endogenous nonlinear optical signals. By employing the spectral lifetime detection capability, this technology provides a unique approach to sensing the fine structure, the protein distribution, and the cellular metabolism of epithelial tissue in vivo. In particular, we investigated the two-photon excitation fluorescence (TPEF) of tryptophan, an essential amino acid serving as the building block of protein. Our findings show that the TPEF of cellular tryptophan produces a good contrast to reveal the morphology of the epithelial cell layer, and the contrast can be further enhanced by applying low-concentration acetic acid.",
        "keywords": [
            "epithelial cell",
            "second harmonic generation",
            "fine structure",
            "nonlinear optics",
            "nucleotides"
        ],
        "authors": [
            {
                "name": "Dong Li",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            },
            {
                "name": "Jianan Y. Qu",
                "org": "Department of Electronic and Computer Engineering|Science and Technology"
            }
        ],
        "venue": "Optics letters",
        "year": 2009
    },
    "2e4tzoOD": {
        "id": "2e4tzoOD",
        "title": "Real-time  Diagnosis of Nasopharyngeal Carcinoma Using Rapid Fiber-Optic Raman Spectroscopy.",
        "abstract": "We report the utility of a simultaneous fingerprint (FP) (i.e., 800-1800 cm) and high-wavenumber (HW) (i.e., 2800-3600 cm) fiber-optic Raman spectroscopy developed for real-time  diagnosis of nasopharyngeal carcinoma (NPC) at endoscopy. A total of 3731 high-quality  FP/HW Raman spectra (normal=1765; cancer=1966) were acquired in real-time from 204 tissue sites (normal=95; cancer=109) of 95 subjects (normal=57; cancer=38) undergoing endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous nasopharyngeal tissues that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in NPC. Principal components analysis (PCA) and linear discriminant analysis (LDA) together with leave-one subject-out, cross-validation (LOO-CV) were implemented to develop robust Raman diagnostic models. The simultaneous FP/HW Raman spectroscopy technique together with PCA-LDA and LOO-CV modeling provides a diagnostic accuracy of 93.1% (sensitivity of 93.6%; specificity of 92.6%) for nasopharyngeal cancer identification, which is superior to using either FP (accuracy of 89.2%; sensitivity of 89.9%; specificity of 88.4%) or HW (accuracy of 89.7%; sensitivity of 89.0%; specificity of 90.5%) Raman technique alone. Further receiver operating characteristic (ROC) analysis reconfirms the best performance of the simultaneous FP/HW Raman technique for  diagnosis of NPC. This work demonstrates for the first time that simultaneous FP/HW fiber-optic Raman spectroscopy technique has great promise for enhancing real-time  cancer diagnosis in the nasopharynx during endoscopic examination.",
        "keywords": [
            "Fiber-optic Raman spectroscopy",
            "In vivo diagnosis",
            "Nasopharyngeal carcinoma"
        ],
        "authors": [
            {
                "name": "Kan Lin",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119260."
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119260."
            },
            {
                "name": "Chwee Ming Lim",
                "org": "Department of Otolaryngology, Head and Neck Surgery, National University of Singapore and National University Health System, Singapore 119074."
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576."
            }
        ],
        "venue": "Theranostics",
        "year": 2017
    },
    "GjC2qzB3": {
        "id": "GjC2qzB3",
        "title": "Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates.",
        "abstract": "We report on a low-level detection of anti-cancer drug (paclitaxel) in blood plasma using microwave-treated gold (Au) film-polystyrene (PS) beads as surface-enhanced Raman scattering (SERS) substrates. SERS spectra of paclitaxel can be acquired within 10s at a concentration of 1\u00d710(-8) M in blood plasma adsorbed on the modified Au-PS SERS substrates. The concentrations of paclitaxel ranging from 1.0\u00d710(-8) to 1.0\u00d710(-7) M in blood plasma can be well estimated with an accuracy of \u223c3.8\u00d710(-9) M using SERS technique. This work shows the promise of applying microwave-modified Au-PS as SERS substrates for rapid and accurate monitoring of the anti-cancer drug in blood plasma for immediate treatment decisions during cancer therapy.",
        "keywords": [
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "Clement Yuen",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9, Engineering Drive 1, Singapore 117576, Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9, Engineering Drive 1, Singapore 117576, Singapore"
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Biosensors & bioelectronics",
        "year": 2010
    },
    "m0uum0l0": {
        "id": "m0uum0l0",
        "title": "An integrated coherent anti-Stokes Raman scattering and multiphoton imaging technique for liver disease diagnosis",
        "abstract": "",
        "keywords": [
            "second harmonic generation",
            "medical diagnostics",
            "optical microscopy",
            "microscopy",
            "chemicals"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "hanry yu",
                "org": "national university of singapore"
            },
            {
                "name": "colin j r sheppard",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2012
    },
    "MoWx3yHL": {
        "id": "MoWx3yHL",
        "title": "Effects of scatterers' sizes on near-field coherent anti-Stokes Raman scattering under tightly focused radially and linearly polarized light excitation.",
        "abstract": "We employ the finite-difference time-domain (FDTD) technique as a numerical approach to studying the effects of scatterers' sizes on near-field coherent anti-Stokes Raman scattering (CARS) microscopy under tightly focused radially and linearly polarized light excitations. The FDTD results show that in a uniform medium (water), the full width at half maximum (FWHM) (transverse resolution) of radially polarized near-field CARS (RP-CARS) radiation is approximately 7.7% narrower than that of linearly polarized near-field CARS (LP-CARS) imaging, whereas the depth of focus (DOF) of RP-CARS radiation is 6.5% longer than LP-CARS. However, with the presence of scatterers in the uniform medium, both the FHWM and DOF of near-field RP-CARS radiation become much narrower compared to those of near-field LP-CARS radiation. In addition, the signal to nonresonant background ratio of near-field RP-CARS is significantly improved when the scatterer's size is larger than a half wavelength of the pump light field. This work suggests that near-field CARS radiations are strongly influenced by the scatterers' sizes in the medium; and near-field RP-CARS microscopy is superior to the near-field LP-CARS by providing both higher transverse and axial resolutions for three-dimensional molecular imaging of fine structures in biological systems.",
        "keywords": [
            "polarized light",
            "polarization",
            "near field"
        ],
        "authors": [
            {
                "name": "Jian Lin",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Haifeng Wang",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2010
    },
    "dThFA8cN": {
        "id": "dThFA8cN",
        "title": "Epi-detected Hyperspectral Stimulated Raman Scattering Microscopy for Label-free Molecular Subtyping of Glioblastomas.",
        "abstract": "We report the development and implementation of an epi-detected spectral-focusing hyperspectral stimulated Raman scattering (SRS) imaging technique for label-free biomolecular subtyping of glioblastomas (GBMs). The hyperspectral SRS imaging technique developed generates SRS image stacks (from 2800 to 3020 cm-1 at 7 cm-1 intervals) within 30 s through controlling the time delay between the chirped pump and Stokes beams. SRS images at representative Raman shifts (e.g., 2845, 2885 and 2935 cm-1) delineate the biochemical variations and morphological differences between proneural and mesenchymal subtypes of GBMs. Multivariate curve resolution (MCR) analysis on hyperspectral SRS images enables the quantification of major biomolecule distributions in mesenchymal and proneural GBMs. Further principal component analysis (PCA) and linear discriminant analysis (LDA) together with leave-one SRS spectrum-out, cross-validation (LOOCV) yields a diagnostic sensitivity of 96.7% (29/30) and specificity of 88.9% (28/36) for differentiation between mesenchymal and proneural subtypes of GBMs. This study shows great potential of applying hyperspectral SRS imaging technique developed for rapid, label-free molecular subtyping of GBMs in neurosurgery.",
        "keywords": "",
        "authors": [
            {
                "name": "Bae Kideog",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "See Wee Lim",
                "org": "National Neuroscience Institute, Singapore 308433"
            },
            {
                "name": "Yuk Kien Chong",
                "org": "National Neuroscience Institute, Singapore 308433"
            },
            {
                "name": "Carol Tang",
                "org": "National Neuroscience Institute, Singapore 308433"
            },
            {
                "name": "Nicolas King",
                "org": "National Neuroscience Institute, Singapore 308433"
            },
            {
                "name": "Christopher Beng Ti Ang",
                "org": "National Neuroscience Institute, Singapore 308433"
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            }
        ],
        "venue": "Analytical chemistry",
        "year": 2018
    },
    "HIS2uvcN": {
        "id": "HIS2uvcN",
        "title": "Integrated Mueller-matrix near-infrared imaging and point-wise spectroscopy improves colonic cancer detection.",
        "abstract": "We report the development and implementation of a unique integrated Mueller-matrix (MM) near-infrared (NIR) imaging and Mueller-matrix point-wise diffuse reflectance (DR) spectroscopy technique for improving colonic cancer detection and diagnosis. Point-wise MM DR spectra can be acquired from any suspicious tissue areas indicated by MM imaging. A total of 30 paired colonic tissue specimens (normal vs. cancer) were measured using the integrated MM imaging and point-wise MM DR spectroscopy system. Polar decomposition algorithms are employed on the acquired images and spectra to derive three polarization metrics including depolarization, diattentuation and retardance for colonic tissue characterization. The decomposition results show that tissue depolarization and retardance are significantly decreased (p<0.001, paired 2-sided Student's t-test, n = 30); while the tissue diattentuation is significantly increased (p<0.001, paired 2-sided Student's t-test, n = 30) associated with colonic cancer. Further partial least squares discriminant analysis (PLS-DA) and leave-one tissue site-out, cross validation (LOSCV) show that the combination of the three polarization metrics provide the best diagnostic accuracy of 95.0% (sensitivity: 93.3%, and specificity: 96.7%) compared to either of the three polarization metrics (sensitivities of 93.3%, 83.3%, and 80.0%; and specificities of 90.0%, 96.7%, and 80.0%, respectively, for the depolarization, diattentuation and retardance metrics) for colonic cancer detection. This work suggests that the integrated MM NIR imaging and point-wise MM NIR diffuse reflectance spectroscopy has the potential to improve the early detection and diagnosis of malignant lesions in the colon. ",
        "keywords": [
            "(170.0110) Imaging systems",
            "(170.3890) Medical optics instrumentation",
            "(170.4580) Optical diagnostics for medicine"
        ],
        "authors": [
            {
                "name": "Jianfeng Wang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            },
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            }
        ],
        "venue": "Biomedical optics express",
        "year": 2016
    },
    "48zNNInX": {
        "id": "48zNNInX",
        "title": "Monitoring cellular metabolic pathways by wavelength- and time-resolved intracellular autofluorescence",
        "abstract": "",
        "keywords": [
            "cancer",
            "time resolved spectroscopy",
            "spectroscopy",
            "luminescence",
            "fluorescence spectroscopy",
            "metabolic pathway"
        ],
        "authors": [
            {
                "name": "yicong wu",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "jDyxPGq0": {
        "id": "jDyxPGq0",
        "title": "Detection of cell metabolism via wavelength- and time-resolved intracellular autofluorescence",
        "abstract": "",
        "keywords": [
            "cancer",
            "cell culture",
            "luminescence",
            "fluorescence spectroscopy",
            "exponential function"
        ],
        "authors": [
            {
                "name": "yicong wu",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "T8oTYhN8": {
        "id": "T8oTYhN8",
        "title": "Diagnosis potential of near infrared Mueller Matrix imaging for colonic adenocarcinoma",
        "abstract": "Mueller matrix imaging along with polar decomposition method was employed for the colonic adenocarcinoma detection by polarized light in the near-infrared spectral range (700\u20131100 nm). A high-speed (u003c5s) Muller matrix imaging system with dual-rotating waveplates was developed. 16 (4 by 4) full Mueller matrices of the colonic tissues (i.e., normal and caner) were acquired. Polar decomposition was further implemented on the 16 images to derive the diattentuation, depolarization, and the retardance images. The decomposed images showed clear margin between the normal and adenocarcinomaous colon tissue samples. The work shows the potential of near-infrared Mueller matrix imaging for the early diagnosis and detection of malignant lesions in the colon.",
        "keywords": "",
        "authors": [
            {
                "name": "Jianfeng Wang",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Kan Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "ORJWGXRy": {
        "id": "ORJWGXRy",
        "title": "Half-ball lens couples a beveled fiber probe for depth-resolved spectroscopy: Monte Carlo simulations.",
        "abstract": "In this study, we propose a beveled fiber-optic probe coupled with a half-ball lens for improving the depth-resolved fluorescence measurements of epithelial tissue. The Monte Carlo (MC) simulation results show that for a given excitation-collection fiber separation, the probe design with a bevel-angled collection fiber is more sensitive to detect fluorescence photons emitted from the shallow layer of tissue, whereas the flat-tip collection fiber is in favor of probing fluorescence photons originating from deeper tissue areas. This compact half-ball lens-beveled fiber probe design has the potential to facilitate the depth-resolved fluorescence detection of epithelial tissue.",
        "keywords": [
            "butefficientspectroscopicprobethatcandifferentiate the origins of fluorescence from different tissue depths is critical to further understand tissue car- cinogenesis and to improve tissue diagnostics at endoscopy. different fiber-optic probe designs have been re- ported for in vivo depth-resolved fluorescence mea- surements of epithelial tissues. generally",
            "these",
            "fiber optics",
            "monte carlo simulation",
            "fiber optic",
            "monte carlo"
        ],
        "authors": [
            {
                "name": "Franck Jaillon",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Applied optics",
        "year": 2008
    },
    "31teSb1o": {
        "id": "31teSb1o",
        "title": "Annular aperture-detected coherent anti-Stokes Raman scattering microscopy for high contrast vibrational imaging",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "stimulated raman scattering",
            "raman scattering",
            "optical microscopy",
            "epithelial cell"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Applied Physics Letters",
        "year": 2010
    },
    "MlWvtwFY": {
        "id": "MlWvtwFY",
        "title": "Multimodal endoscopic imaging and Raman spectroscopy for improving in vivo diagnosis of gastric malignancies during clinical gastroscopy",
        "abstract": "",
        "keywords": [
            "medical diagnostics",
            "nucleic acid",
            "system integration",
            "cancer",
            "discriminant analysis",
            "raman spectra",
            "niobium",
            "near infrared",
            "cross validation",
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "kan lin",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "jimmy bok yan so",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2010
    },
    "7AaNE30H": {
        "id": "7AaNE30H",
        "title": "Study of acetowhitening mechanisms in live mammalian cells with label-free subcellular-level multimodal nonlinear optical microscopy",
        "abstract": "",
        "keywords": [
            "photons",
            "scattering",
            "proteins",
            "optical microscopy",
            "luminescence"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "sengkhoon teh",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zi wang",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "qUy7UroW": {
        "id": "qUy7UroW",
        "title": "A specially modified surface-enhanced Raman spectroscopy (SERS) substrate for biomedical applications",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "plasmonics",
            "chemicals",
            "nanotechnology"
        ],
        "authors": [
            {
                "name": "clement yuen",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2008
    },
    "AQVpfRXZ": {
        "id": "AQVpfRXZ",
        "title": "Simultaneous fingerprint and high-wavenumber fiber-optic Raman endoscopy for in vivo diagnosis of laryngeal cancer",
        "abstract": "We report a unique simultaneous fingerprint (FP) and high-wavenumber (HW) fiber-optic confocal Ramanspectroscopy for in vivo diagnosis of laryngeal cancer in the head and neck under wide-field endoscopicimaging. The simultaneous FP and HW Raman endoscopy technique was performed on 21 patients anddifferentiated laryngeal carcinoma from normal tissues with both sensitivity and specificity of ~85%. Thisstudy shows the great potential of the FP/HW Raman endoscopic technique developed for  in vivo  diagnosisof laryngeal carcinoma during routine endoscopic examination.",
        "keywords": "",
        "authors": [
            {
                "name": "Kan Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Jianfeng Wang",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Chwee Ming Lim",
                "org": "National Univ. Hospital (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "QkJnWhDJ": {
        "id": "QkJnWhDJ",
        "title": "Real-time depth-resolved Raman endoscopy for in vivo diagnosis of dysplasia in Barrett's esophagus",
        "abstract": "",
        "keywords": [
            "reflectivity",
            "raman spectroscopy",
            "near infrared",
            "algorithms",
            "medical diagnostics"
        ],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "jimmy bok yan so",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2013
    },
    "8ejs5pWp": {
        "id": "8ejs5pWp",
        "title": "Image\u2010Guided Raman Spectroscopy For In Vivo Diagnosis of Gastric Precancer At Gastroscopy",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "raman spectra"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "kan lin",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2010
    },
    "TrUynaRs": {
        "id": "TrUynaRs",
        "title": "Annular aperture detection scheme in radially polarized coherent anti-Stokes Raman scattering (RP-CARS) microscopy for contrast improvement",
        "abstract": "",
        "keywords": [
            "radiation",
            "finite difference time domain",
            "microscopy"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "haifeng wang",
                "org": "data storage institute"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "colin j r sheppard",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Bios",
        "year": 2010
    },
    "tnqwIl0k": {
        "id": "tnqwIl0k",
        "title": "Polarization-resolved hyperspectral stimulated Raman microscopy for tooth imaging",
        "abstract": "We report the development and implementation of a rapid polarization-resolved hyperspectral stimulated Raman scattering imaging technique for enhancing optical diagnosis and characterization of dental caries in the tooth without labeling.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhiwei Huang",
                "org": "OpticalBioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Zi Wang",
                "org": "OpticalBioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Wei Zheng",
                "org": "OpticalBioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576"
            },
            {
                "name": "Stephen Chin-Ying Hsu",
                "org": "Department of Preventive Dentistry, Faculty of Dentistry, National University of Singapore and National University Health System, Singapore 119083"
            }
        ],
        "venue": "conference on lasers and electro optics",
        "year": 2016
    },
    "rCsEf1qW": {
        "id": "rCsEf1qW",
        "title": "Multi-color Excitation Nonlinear Microscopy of Biological Tissue",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jianan y qu",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "dong li",
                "org": ""
            }
        ],
        "venue": "IEEE Transactions on Biomedical Engineering",
        "year": 2010
    },
    "NDnQLXTu": {
        "id": "NDnQLXTu",
        "title": "Time-resolved confocal fluorescence spectroscopy reveals the structure and metabolic state of epithelial tissue",
        "abstract": "",
        "keywords": [
            "pathology",
            "exponential function",
            "medical diagnostics",
            "luminescence",
            "biochemistry",
            "spectroscopy",
            "fluorescence spectroscopy",
            "cancer"
        ],
        "authors": [
            {
                "name": "yicong wu",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "BgTKZV4Q": {
        "id": "BgTKZV4Q",
        "title": "In vivo diagnosis of cervical precancer using high wavenumber Raman spectroscopy",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "near infrared",
            "principal component analysis",
            "multivariate statistics",
            "fiber optics",
            "medical diagnostics",
            "cancer",
            "fingerprint recognition",
            "fiber optic"
        ],
        "authors": [
            {
                "name": "jianhua mo",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "jeffrey low",
                "org": "national university of singapore"
            },
            {
                "name": "joseph ng",
                "org": "national university of singapore"
            },
            {
                "name": "a ilancheran",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2007
    },
    "TZy3YWlL": {
        "id": "TZy3YWlL",
        "title": "Autofluorescence of epithelial tissue: single-photon versus two-photon excitation.",
        "abstract": "We instrumented a combined fluorescence spectroscopy and imaging system to characterize the single- and two-photon excited autofluorescence in epithelial tissue. Single-photon fluorescence (SPF) are compared with two-photon fluorescence (TPF) measured at the same location in epithelial tissue. It was found that the SPF and TPF signals excited at corresponding wavelengths are similar in nonkeratinized epithelium, but the SPF and TPF spectra in the keratinized epithelium and the stromal layer are significant different. Specifically, the comparison of SPF signals with TPF signals in keratinized epithelial and stromal layers shows that TPF spectral peaks always have about 15-nm redshift with respect to SPF signals, and the TPF spectra are broader than SPF spectra. The results were generally consistent with the SPF and TPF measurements of pure nicotinamide adenine dinucleotide, flavin adenine dinucleotide, keratin and collagen, the major fluorophores in epithelium and stroma, respectively. The double peak structure of TPF spectra measured from keratinized layer suggests that there may be an unknown fluorophore responsible for the spectral peak in the long wavelength region. Furthermore, the TPF signals excited in a wide range of wavelengths provide accurate information on epithelial structure, which is an important advantage of TPF over SPF spectroscopy in the application for the diagnosis of tissue pathology.",
        "keywords": [
            "two-photon spectroscopy",
            "autofluorescence",
            "epithelial tissue.",
            "confocal microscopy",
            "photons",
            "luminescence",
            "second harmonic generation",
            "fluorescence spectroscopy"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Yicong Wu",
                "org": ""
            },
            {
                "name": "Dong Li",
                "org": ""
            },
            {
                "name": "Jianan Y. Qu",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2008
    },
    "b9g8g287": {
        "id": "b9g8g287",
        "title": "Sa1831 Image-Guided Raman Spectroscopy for Real-Time In Vivo Diagnosis of Barrett's Esophagus During Endoscopic Examination",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "khekyu ho",
                "org": ""
            },
            {
                "name": "ming teh",
                "org": ""
            },
            {
                "name": "khay guan yeoh",
                "org": ""
            },
            {
                "name": "jimmy b so",
                "org": ""
            },
            {
                "name": "asim shabbir",
                "org": ""
            },
            {
                "name": "zhiwei huang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2012
    },
    "mFNbtRTV": {
        "id": "mFNbtRTV",
        "title": "Numerical study of effects of light polarization, scatterer sizes and orientations on near-field coherent anti-Stokes Raman scattering microscopy.",
        "abstract": "We employ the finite-difference time-domain (FDTD) technique as a numerical approach to studying the effects of polarization, scatterers' sizes and orientations on near-field coherent anti-Stokes Raman scattering (CARS) microscopy imaging. The results show that to acquire better image contrast and larger near-field CARS signals, the scatterers with diameters of less than three-eighths of the pump field wavelength (lambda(p)) are preferable to be oriented along the polarization direction of the excitation light fields. It is also found that when the scatterers' sizes are smaller than half a wavelength of the pump field, the perpendicular polarization component of the induced near-field CARS radiations is strictly confined within the regions at the scatterer-water interface or the subsurface of scatterers, yielding a high image contrast (up to 200) with a spatial resolution of lambda(p)/16. This study indicates that perpendicular polarization components of near-field CARS microscopy could be used to uncover very fine structures of intra- and/or inter- cellular organelles in cells with nanoscale resolutions.",
        "keywords": [
            "near field"
        ],
        "authors": [
            {
                "name": "Jian Lin",
                "org": ""
            },
            {
                "name": "Haifeng Wang",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Fake Lu",
                "org": ""
            },
            {
                "name": "Colin Sheppard",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Optics express",
        "year": 2009
    },
    "ZL1mswvq": {
        "id": "ZL1mswvq",
        "title": "Two-photon excited fluorescence emission from hemoglobin",
        "abstract": "",
        "keywords": [
            "oxygen",
            "catalysis",
            "luminescence",
            "photons",
            "proteins",
            "iron",
            "molecules",
            "electrons"
        ],
        "authors": [
            {
                "name": "qiqi sun",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "yan zeng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zhang",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "yi luo",
                "org": "university of science and technology of china"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "",
        "year": 2015
    },
    "vQh6FpE7": {
        "id": "vQh6FpE7",
        "title": "Integrated Raman spectroscopy and trimodal wide-field imaging techniques for real-time in vivo tissue Raman measurements at endoscopy.",
        "abstract": "We report an integrated Raman spectroscopy and trimodal (white-light reflectance, autofluorescence, and narrow-band) imaging techniques for real-time in vivo tissue Raman measurements at endoscopy. A special 1.8 mm endoscopic Raman probe with filtering modules is developed, permitting effective elimination of interference of fluorescence background and silica Raman in fibers while maximizing tissue Raman collections. We demonstrate that high-quality in vivo Raman spectra of upper gastrointestinal tract can be acquired within 1 s or subseconds under the guidance of wide-field endoscopic imaging modalities, greatly facilitating the adoption of Raman spectroscopy into clinical research and practice during routine endoscopic inspections.",
        "keywords": [
            "real time",
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "Zhiwei Huang",
                "org": ""
            },
            {
                "name": "Seng Khoon Teh",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Jianhua Mo",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Xiaozhuo Shao",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2009
    },
    "QyOYNOgB": {
        "id": "QyOYNOgB",
        "title": "Near-infrared Raman spectroscopy for colonic cancer diagnosis",
        "abstract": "",
        "keywords": [
            "raman spectroscopy",
            "near infrared",
            "cancer",
            "colon cancer",
            "medical diagnostics",
            "raman spectra",
            "colorectal cancer"
        ],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "sheppard colin",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2005
    },
    "HEJofLhd": {
        "id": "HEJofLhd",
        "title": "Diagnosis of gastric cancer using near-infrared Raman spectroscopy and classification and regression tree techniques",
        "abstract": "The purpose of this study is to apply near-infrared NIR Raman spectroscopy and classification and regression tree CART techniques for identifying molecular changes of tissue associated with cancer transformation. A rapid-acquisition NIR Raman system is uti- lized for tissue Raman spectroscopic measurements at 785-nm exci- tation. 73 gastric tissue samples 55 normal, 18 cancer from 53 pa- tients are measured. The CART technique is introduced to develop effective diagnostic algorithms for classification of Raman spectra of different gastric tissues. 80% of the Raman dataset are randomly se- lected for spectral learning, while 20% of the dataset are reserved for validation. High-quality Raman spectra in the range of 800 to 1800 cm\u007f1 are acquired from gastric tissue within 5s . The diagnostic sensitivity and specificity of the learning dataset are 90.2 and 95.7%; and the predictive sensitivity and specificity of the inde- pendent validation dataset are 88.9 and 92.9%, respectively, for sepa- rating cancer from normal. The tissue Raman peaks at 875 and 1745 cm\u007f1 are found to be two of the most significant features to discriminate gastric cancer from normal tissue. NIR Raman spectros- copy in conjunction with the CART technique has the potential to provide an effective and accurate diagnostic means for cancer detec- tion in the gastric system. \u00a9 2008 Society of Photo-Optical Instrumentation Engineers.",
        "keywords": [
            "cancer diagnosis",
            "classifi- cation and regression tree.",
            "stomach",
            "near-infrared raman spectroscopy",
            "raman spectroscopy",
            "near infrared",
            "raman spectra",
            "regression tree",
            "medical diagnostics",
            "cancer"
        ],
        "authors": [
            {
                "name": "Seng Khoon Teh",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Journal of Biomedical Optics",
        "year": 2008
    },
    "DfqsQHms": {
        "id": "DfqsQHms",
        "title": "Real-time in vivo diagnosis of laryngeal carcinoma with rapid fiber-optic Raman spectroscopy.",
        "abstract": "We assess the clinical utility of a unique simultaneous fingerprint (FP) (i.e., 800-1800 cm) and high-wavenumber (HW) (i.e., 2800-3600 cm) fiber-optic Raman spectroscopy for  diagnosis of laryngeal cancer at endoscopy. A total of 2124 high-quality  FP/HW Raman spectra (normal = 1321; cancer = 581) were acquired from 101 tissue sites (normal = 71; cancer = 30) of 60 patients (normal = 44; cancer = 16) undergoing routine endoscopic examination. FP/HW Raman spectra differ significantly between normal and cancerous laryngeal tissue that could be attributed to changes of proteins, lipids, nucleic acids, and the bound water content in the larynx. Partial least squares-discriminant analysis and leave-one tissue site-out, cross-validation were employed on the in vivo FP/HW tissue Raman spectra acquired, yielding a diagnostic accuracy of 91.1% (sensitivity: 93.3% (28/30); specificity: 90.1% (64/71)) for laryngeal cancer identification, which is superior to using either FP (accuracy: 86.1%; sensitivity: 86.7% (26/30); specificity: 85.9% (61/71)) or HW (accuracy: 84.2%; sensitivity: 76.7% (23/30); specificity: 87.3% (62/71)) Raman technique alone. Further receiver operating characteristic analysis reconfirms the best performance of the simultaneous FP/HW Raman technique for laryngeal cancer diagnosis. We demonstrate for the first time that the simultaneous FP/HW Raman spectroscopy technique can be used for improving real-time  diagnosis of laryngeal carcinoma during endoscopic examination.",
        "keywords": [
            "(120.3890) Medical optics instrumentation",
            "(170.5660) Raman spectroscopy",
            "(170.6510) Spectroscopy",
            "tissue diagnostics"
        ],
        "authors": [
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 119260 Singapore."
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 119260 Singapore."
            },
            {
                "name": "Chwee Ming Lim",
                "org": "Department of Otolaryngology, Head and Neck Surgery, National University of Singapore and National University Health System, 119074 Singapore."
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            }
        ],
        "venue": "Biomedical optics express",
        "year": 2016
    },
    "9BIae3J3": {
        "id": "9BIae3J3",
        "title": "Characterizing Variability of In Vivo Raman Spectroscopic Properties of Different Anatomical Sites of Normal Colorectal Tissue towards Cancer Diagnosis at Colonoscopy",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "khay guan yeoh",
                "org": ""
            },
            {
                "name": "ming teh",
                "org": ""
            },
            {
                "name": "khek yu ho",
                "org": ""
            },
            {
                "name": "jianlin ren",
                "org": ""
            },
            {
                "name": "hongzhi xu",
                "org": ""
            },
            {
                "name": "jianfeng wang",
                "org": ""
            },
            {
                "name": "kan lin",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "mads sylvest bergholt",
                "org": ""
            }
        ],
        "venue": "Analytical Chemistry",
        "year": 2015
    },
    "BQI3GD5V": {
        "id": "BQI3GD5V",
        "title": "Dental caries imaging using hyperspectral stimulated Raman scattering microscopy",
        "abstract": "We report the development of a polarization-resolved hyperspectral stimulated Raman scattering (SRS) imaging technique based on a picosecond (ps) laser-pumped optical parametric oscillator system for label-free imaging of dental caries. In our imaging system, hyperspectral SRS images (512\u00d7512 pixels) in both fingerprint region (800-1800 cm -1 ) and high-wavenumber region (2800-3600 cm -1 ) are acquired in minutes by scanning the wavelength of OPO output, which is a thousand times faster than conventional confocal micro Raman imaging. SRS spectra variations from normal enamel to caries obtained from the hyperspectral SRS images show the loss of phosphate and carbonate in the carious region. While polarization-resolved SRS images at 959 cm -1  demonstrate that the caries has higher depolarization ratio. Our results demonstrate that the polarization resolved-hyperspectral SRS imaging technique developed allows for rapid identification of the biochemical and structural changes of dental caries.",
        "keywords": "",
        "authors": [
            {
                "name": "Zi Wang",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Wei Zheng",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Jian Lin",
                "org": "National Univ. of Singapore (Singapore)"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National Univ. of Singapore (Singapore)"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2016
    },
    "Vw5ibBBg": {
        "id": "Vw5ibBBg",
        "title": "Univariate and multivariate methods for chemical mapping of cervical cancer cells",
        "abstract": "",
        "keywords": [
            "cancer",
            "microscopy",
            "luminescence",
            "visualization",
            "spatial resolution",
            "chemicals",
            "lasers",
            "spectroscopy"
        ],
        "authors": [
            {
                "name": "shiyamala duraipandian",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2012
    },
    "drSg326A": {
        "id": "drSg326A",
        "title": "Study of cadmium-induced cytotoxicity using two-photon excitation endogenous fluorescence microscopy.",
        "abstract": "We demonstrate that using time-resolved two-photon excitation endogenous fluorescence microscopy, the cadmium (Cd)-induced cellular toxic level can be assessed by the free-to protein-bound reduced nicotinamide adenine dinucleotide (free/bound NADH) ratio in a living cell. NADH fluorescence excited at 730 nm is captured at different times following exposure to cadmium at a variety of concentrations. The temporal characteristics of NADH fluorescence from mitochondrial and nuclear compartments are analyzed, respectively. The results show that cadmium induces a significant increase of the free/bound NADH ratio in mitochondria and nucleus, caused by the inhibition effect on the electron transport chain (ETC) and the stimulating effect on the glycolysis pathway, respectively. It is found that induction of metallothionein (MT) in cells occurs after 4 h of exposure to a sublethal concentration of Cd and reaches a peak at 6 h. More importantly, the increase in MT level can effectively suppress the elevation of the free/bound NADH ratio caused by a subsequent exposure to a higher concentration of Cd, indicating that MT plays a key role in protecting cells from Cd-induced toxicity. Our findings show that the free/bound NADH ratio can potentially be used as a sensitive indicator of toxic and carcinogenic actions induced by Cd.",
        "keywords": [
            "metabolism",
            "metallothionein.",
            "multiphoton microscopy",
            "cad- mium toxicity",
            "time-resolved fluorescence",
            "metallothionein",
            "photons",
            "fluorescence microscopy",
            "microscopy",
            "luminescence",
            "kinetics",
            "cadmium",
            "electron transport chain"
        ],
        "authors": [
            {
                "name": "Dong Li",
                "org": ""
            },
            {
                "name": "Mildred S. Yang",
                "org": ""
            },
            {
                "name": "Tao Lin",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Jianan Y. Qu",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2009
    },
    "3IIet65T": {
        "id": "3IIet65T",
        "title": "Optical diagnosis and characterization of dental caries with polarization-resolved hyperspectral stimulated Raman scattering microscopy.",
        "abstract": "We report the utility of a rapid polarization-resolved hyperspectral stimulated Raman scattering (SRS) imaging technique developed for optical diagnosis and characterization of dental caries in the tooth. Hyperspectral SRS images (512 \u00d7 512 pixels) of the tooth covering both the fingerprint (800-1800 cm(-1)) and high-wavenumber (2800-3600 cm(-1)) regions can be acquired within 15 minutes, which is at least 10(3) faster in imaging speed than confocal Raman mapping. Hyperspectral SRS imaging uncovers the biochemical distributions and variations across the carious enamel in the tooth. SRS imaging shows that compared to the sound enamel, the mineral content in the body of lesion decreases by 55%; while increasing up to 110% in the surface zone, indicating the formation of a hyper-mineralized layer due to the remineralization process. Further polarized SRS imaging shows that the depolarization ratios of hydroxyapatite crystals (\u03bd 1-PO4 (3-) of SRS at 959 cm(-1)) of the tooth in the sound enamel, translucent zone, body of lesion and the surface zone are 0.035 \u00b1 0.01, 0.052 \u00b1 0.02, 0.314 \u00b1 0.1, 0.038 \u00b1 0.02, respectively, providing a new diagnostic criterion for discriminating carious lesions from sound enamel in the teeth. This work demonstrates for the first time that the polarization-resolved hyperspectral SRS imaging technique can be used for quantitatively determining tooth mineralization levels and discriminating carious lesions from sound enamel in a rapid fashion, proving its promising potential of early detection and diagnosis of dental caries without labeling. ",
        "keywords": [
            "(170.1850) Dentistry",
            "(180.4315) Nonlinear microscopy",
            "(180.5655) Raman microscopy",
            "(190.4180) Multiphoton processes"
        ],
        "authors": [
            {
                "name": "Zi Wang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 119260 Singapore."
            },
            {
                "name": "Stephen Chin-Ying Hsu",
                "org": "Department of Dentistry, Faculty of Dentistry, National University Health System and National University of Singapore, 119083 Singapore."
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, 117576 Singapore."
            }
        ],
        "venue": "Biomedical optics express",
        "year": 2016
    },
    "UCEmvWp4": {
        "id": "UCEmvWp4",
        "title": "Real-time depth-resolved fiber optic Raman endoscopy for in vivo diagnosis of gastric precancer",
        "abstract": "",
        "keywords": [
            "light scattering",
            "algorithms",
            "medical diagnostics",
            "raman spectroscopy",
            "reflectivity",
            "near infrared",
            "fiber optics"
        ],
        "authors": [
            {
                "name": "mads sylvest bergholt",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "jimmy bok yan so",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "8Yfl7OP8": {
        "id": "8Yfl7OP8",
        "title": "High wavenumber Raman spectroscopy for in vivo detection of cervical dysplasia.",
        "abstract": "Raman spectroscopy is a vibrational spectroscopic technique capable of optically probing the biomolecular changes associated with neoplastic transformation. The purpose of this study was to apply near-infrared (NIR) Raman spectroscopy in the high wavenumber (HW) region (2800-3700 cm(-1)) for in vivo detection of cervical dysplasia. A rapid-acquisition NIR Raman spectroscopy system associated with a ball-lens fiber-optic Raman probe was developed for in vivo spectroscopic measurements at 785 nm excitation. A total of 92 in vivo HW Raman spectra (46 normal, 46 dysplasia) were acquired from 46 patients with Pap smear abnormalities of the cervix. Significant difference in Raman intensities of prominent Raman bands at 2850 and 2885 cm(-1) (CH(2) stretching of lipids), 2940 cm(-1) (CH(3) stretching of proteins), and the broad Raman band of water (peaking at 3400 cm(-1) in the 3100-3700 cm(-1) range) were observed in normal and dysplasia cervical tissue. The diagnostic algorithms based on principal components analysis and linear discriminant analysis together with the leave-one-patient-out cross-validation method on in vivo HW Raman spectra yielded a diagnostic sensitivity of 93.5% and specificity of 97.8% for dysplasia tissue identification. This study demonstrates for the first time that HW Raman spectroscopy has the potential for the noninvasive, in vivo diagnosis and detection of precancer of the cervix.",
        "keywords": [
            "raman spectroscopy"
        ],
        "authors": [
            {
                "name": "Jianhua Mo",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Jeffrey J. H. Low",
                "org": ""
            },
            {
                "name": "Joseph Ng",
                "org": ""
            },
            {
                "name": "A. Ilancheran",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Analytical chemistry",
        "year": 2009
    },
    "s5rdZzYa": {
        "id": "s5rdZzYa",
        "title": "Real-Time Monitoring of Pharmacokinetics of Antibiotics in Biofilms with Raman-Tagged Hyperspectral Stimulated Raman Scattering Microscopy.",
        "abstract": "Antibiotics resistance developed by biofilms has posed a clinical challenge in the effective treatment of bacterial infections. However, the resistance mechanisms have not been well understood due to a lack of suitable tools for dynamic observation of the interplay between antibiotics and biofilm. In this work, with the use of rapid hyperspectral stimulated Raman scattering microscopy associated with an aryl-alkyne-based Raman tag synthesized, we investigate dynamic interactions between vancomycin and Staphylococcus aureus () biofilm to gain new insights into the resistance mechanisms of the biofilm.  We utilize spectral focusing hyperspectral stimulated Raman scattering microscopy ensued with multivariate curve resolution analysis to spectrally decompose  biofilm into its major components (i.e., bacteria and extracellular polymeric substances). Concurrently, vancomycin is conjugated with aryl-alkyne Raman tag (Raman peak at 2218 cm) for  tracking of its uptake into biofilm without tissue interference.  We find that vancomycin penetration is a non-uniform diffusion process with penetration depths limited by the preferential affinity to the cell clusters. Semi-quantitative analysis shows that the majority of vancomycin binds to the bacteria, achieving intracellular concentrations of up to 4- to 10- fold higher than the administered dosage. The diffusion constant of ~3.16 \u00b5m/min based on the diffusion and antibiotic binding equations is obtained that well accounts for the antibiotic penetration into the biofilm. SRS longitudinal monitoring of antibiotic effect on the growth of biofilms shows that the antibiotics can eradicate the upper layer of the biofilm exposed to sufficient dosages, while the lower layer of the biofilm at a sub-inhibitory dose remains viable, eventually re-growing to significant bio-volume.  The Raman-tagged hyperspectral SRS microscopy developed is a powerful imaging tool for dynamic monitoring of inhibitory effects of antibiotics on the growing biofilm , which would facilitate the formulation of new antibiotics for more effective treatments of bacterial infections in near future.",
        "keywords": [
            "Raman tag",
            "antibiotics",
            "biofilm",
            "coherent Raman scattering",
            "stimulated Raman scattering"
        ],
        "authors": [
            {
                "name": "Kideog Bae",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576."
            },
            {
                "name": "Wei Zheng",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119260."
            },
            {
                "name": "Ying Ma",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576."
            },
            {
                "name": "Zhiwei Huang",
                "org": "Optical Bioimaging Laboratory, Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore 117576."
            }
        ],
        "venue": "Theranostics",
        "year": 2019
    },
    "YtSyafbJ": {
        "id": "YtSyafbJ",
        "title": "Supercritical focusing coherent anti-Stokes Raman scattering microscopy for high-resolution vibrational imaging.",
        "abstract": "We report the development of, to the best of our knowledge, a novel supercritical focusing coherent anti-Stokes Raman scattering (SCF-CARS) microscopy for high-resolution vibrational imaging. Two optimized phase patterns with a combination of concentric rings with an alternative 0 and \u03c0 phase are generated by using a spatial light modulator and applied to the pump beam for minimizing its focal spot size. One of the phase patterns is for both the lateral and axial resolution enhancement, and the other can further improve the lateral resolution, but it sacrifices the axial resolution to some extent. We demonstrate this high-resolution SCF-CARS microscopy technique by imaging the polymethyl methacrylate (PMMA) nano-cylinder on a microscope slide and glass-air interface, as well as biomedical samples, for example, tooth.",
        "keywords": "",
        "authors": [
            {
                "name": "Li Gong",
                "org": ""
            },
            {
                "name": "Jian Lin",
                "org": ""
            },
            {
                "name": "Chenglong Hao",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Steve Qing Yang Wu",
                "org": ""
            },
            {
                "name": "Jinghua Teng",
                "org": ""
            },
            {
                "name": "Cheng-Wei Qiu",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Optics letters",
        "year": 2018
    },
    "pCaU4Vb7": {
        "id": "pCaU4Vb7",
        "title": "Diagnostic instrument and method",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "zhiwei huang",
                "org": ""
            },
            {
                "name": "mads sylvest bergholt",
                "org": ""
            },
            {
                "name": "wei zheng",
                "org": ""
            },
            {
                "name": "khek yu ho",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "EhaOmT2G": {
        "id": "EhaOmT2G",
        "title": "Image-guided Raman endoscopy for in vivo detection of high grade dysplasia in gastric",
        "abstract": "The purpose of this study was to investigate the feasibility of near infrared (NIR) Raman spectroscopy coupled with narrow band imaging for distinguishing high grade dysplasia from normal gastric mucosa tissues at gastroscopy.",
        "keywords": [
            "raman spectroscopy",
            "endoscopes",
            "infrared spectroscopy",
            "gastric mucosa",
            "gastroscopy",
            "high grade dysplasia",
            "image guided raman endoscopy",
            "near infrared spectroscopy",
            "170.1610",
            "170.6510",
            "optical scattering",
            "near infrared",
            "spectroscopy",
            "optical imaging",
            "in vivo",
            "biomedical imaging",
            "raman scattering",
            "cancer"
        ],
        "authors": [
            {
                "name": "seng khoon teh",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "khek yu ho",
                "org": "national university of singapore"
            },
            {
                "name": "ming teh",
                "org": "national university of singapore"
            },
            {
                "name": "khay guan yeoh",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Baltimore, MD",
        "year": 2009
    },
    "hA8ZWNqx": {
        "id": "hA8ZWNqx",
        "title": "Rapid near-infrared fluorescence excitation-emission matrix spectroscopy for multifluorophore characterization using an acousto-optic tunable filter technique.",
        "abstract": "We report on a novel acousto-optic tunable filter (AOTF)-based near-infrared (NIR) fluorescence excitation-emission matrix (EEM) spectroscopy technique for rapid multifluorophore characterization. We implement a unique light filtering module design by using cascaded AOTFs coupled with three orthogonally oriented polarizers to effectively remove the side-ripple artifacts of AOTFs as well as by using a pair of AOTFs coupled with two orthogonally oriented polarizers to improve detection efficiency for high-quality fluorescence EEM acquisitions. NIR fluorescence EEM spectroscopy (41 excitation wavelengths ranging from 550 to 950 nm in 10-nm increments; fluorescence emission from 570 to 1000 nm at 10-nm intervals) can be acquired from fluorescence dyes [e.g., diethylthiatricarbocyanine (DTTC) iodide, oxazine 750, and IR 140] within 10 s or even less, illustrating the potential of the AOTF-based NIR EEM technique developed for rapid multifluorophore analysis and characterization in biochemical and biomedical systems.",
        "keywords": [
            "fluorescence spectroscopy",
            "near infrared",
            "spectroscopy",
            "matrices",
            "luminescence",
            "polarizers",
            "optical filters"
        ],
        "authors": [
            {
                "name": "Hao Li",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Journal of biomedical optics",
        "year": 2010
    },
    "FrmJF4Cg": {
        "id": "FrmJF4Cg",
        "title": "Detection of Helicobacter pylori-associated chronic gastritis using NIR Raman spectroscopy",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Seng Khoon Teh",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Khek Yu Ho",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Ming Teh",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Khay Guan Yeoh",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Manuel Salto-Tellez",
                "org": "National University of Singapore, Singapore, Singapore"
            },
            {
                "name": "Zhiwei Huang",
                "org": "National University of Singapore, Singapore, Singapore"
            }
        ],
        "venue": "Cancer Research",
        "year": 2008
    },
    "Xt1PkdVA": {
        "id": "Xt1PkdVA",
        "title": "Integrated coherent Raman scattering and multiphoton microscopy for label-free imaging of the dentin in the tooth",
        "abstract": "",
        "keywords": [
            "optical imaging",
            "photons",
            "second harmonic generation",
            "raman scattering",
            "multiphoton microscopy",
            "luminescence",
            "optical microscopy",
            "teeth"
        ],
        "authors": [
            {
                "name": "zi wang",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "chinying hsu",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "Proceedings of SPIE",
        "year": 2014
    },
    "AWugT9LV": {
        "id": "AWugT9LV",
        "title": "Multimodal nonlinear optical imaging of obesity-induced liver steatosis and fibrosis",
        "abstract": "",
        "keywords": [
            "nonlinear optics",
            "second harmonic generation"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "dean c s tai",
                "org": ""
            },
            {
                "name": "hanry yu",
                "org": "national university of singapore"
            },
            {
                "name": "colin j r sheppard",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "Zx9rBahR": {
        "id": "Zx9rBahR",
        "title": "In vivo multiphoton fluorescence microscopy of epithelial precancer",
        "abstract": "",
        "keywords": [
            "luminescence",
            "three dimensional",
            "fluorescence lifetime",
            "cancer",
            "microscopy",
            "optical microscopy",
            "second harmonic generation",
            "nonlinear optics",
            "biochemistry",
            "fluorescence microscopy",
            "spectroscopy"
        ],
        "authors": [
            {
                "name": "wei zheng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "dong li",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "yan zeng",
                "org": "hong kong university of science and technology"
            },
            {
                "name": "jianan y qu",
                "org": "hong kong university of science and technology"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "NcQwjA1B": {
        "id": "NcQwjA1B",
        "title": "W1162 Raman Endoscopy for In Vivo Diagnosis of Gastric Malignancy: Our Initial Experience",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Seng Khoon Teh",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            },
            {
                "name": "Jimmy B. So",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2010
    },
    "lGUw1amd": {
        "id": "lGUw1amd",
        "title": "High contrast coherent anti-Stokes Raman scattering microscopy using tightly focused cylindrical vector beams",
        "abstract": "",
        "keywords": [
            "radiation",
            "finite difference time domain",
            "microscopy"
        ],
        "authors": [
            {
                "name": "jian lin",
                "org": "national university of singapore"
            },
            {
                "name": "fake lu",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2011
    },
    "CL3tkVxq": {
        "id": "CL3tkVxq",
        "title": "Integrated fingerprint and high wavenumber confocal Raman spectroscopy for in vivo diagnosis of cervical precancer",
        "abstract": "",
        "keywords": [
            "water",
            "medical diagnostics",
            "spectroscopy",
            "raman spectroscopy",
            "fingerprint recognition"
        ],
        "authors": [
            {
                "name": "shiyamala duraipandian",
                "org": "national university of singapore"
            },
            {
                "name": "wei zheng",
                "org": "national university of singapore"
            },
            {
                "name": "joseph ng",
                "org": "national university of singapore"
            },
            {
                "name": "jeffrey j h low",
                "org": "national university of singapore"
            },
            {
                "name": "a ilancheran",
                "org": "national university of singapore"
            },
            {
                "name": "zhiwei huang",
                "org": "national university of singapore"
            }
        ],
        "venue": "",
        "year": 2013
    },
    "S3ESuV92": {
        "id": "S3ESuV92",
        "title": "In vivo detection of epithelial neoplasia in the stomach using image-guided Raman endoscopy.",
        "abstract": "This study explores the utility of a novel image-guided Raman endoscopy technique for in vivo distinction of gastric cancer from normal tissue during clinical gastroscopy. The rapid-acquisition fiber-optic Raman endoscopy system developed was employed for in vivo gastric tissue Raman measurements at 785 nm laser excitation. A total of 1063 in vivo Raman spectra were acquired from 238 tissue sites of 67 gastric patients who underwent endoscopic ultrasound staging procedure, in which 934 Raman spectra were from 121 normal tissue sites whereas 129 Raman spectra were from 117 neoplastic gastric tissue sites. Gastric Raman spectra were fitted and reconstructed by using a linear combination of the eight basis reference spectra from the biochemicals (i.e., actin, albumin, collagen, DNA, histones, pepsinogen, phospholipids and triolein) in gastric tissue and also compared with the in vivo gastric Raman spectra measured. The resulting fit coefficients were further utilized through recursive partitioning techniques to develop diagnostic algorithms for gastric cancer diagnosis. High-quality in vivo Raman spectra in the range of 800-1800 cm(-1) can be acquired from gastric mucosa within 0.5s. The fit coefficients from albumin, nucleic acid, phospholipids and histones were found to be the most significant features for construction of the diagnostic model, giving rise to an overall accuracy of 93.7% (i.e., sensitivity of 94.0% (110/117) and specificity of 93.4% (113/121)) for in vivo discrimination of cancerous tissue from normal gastric tissue after the leave-one tissue site-out, cross-validation technique. This work demonstrates for the first time that image-guided Raman endoscopy technique has promising potential for the non-invasive, in vivo diagnosis and detection of gastric cancer at the molecular level.",
        "keywords": [
            "raman spectra",
            "cross validation",
            "fiber optic",
            "nucleic acid",
            "recursive partitioning"
        ],
        "authors": [
            {
                "name": "Zhiwei Huang",
                "org": ""
            },
            {
                "name": "Seng Khoon Teh",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9, Engineering Drive 1,Singapore 117576, Singapore"
            },
            {
                "name": "Wei Zheng",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9, Engineering Drive 1,Singapore 117576, Singapore"
            },
            {
                "name": "Kan Lin",
                "org": "Optical Bioimaging Laboratory, Department of Bioengineering, Faculty of Engineering, National University of Singapore, 9, Engineering Drive 1,Singapore 117576, Singapore"
            },
            {
                "name": "Khek Yu Ho",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital System, Singapore 119260, Singapore"
            },
            {
                "name": "Ming Teh",
                "org": "Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital System, Singapore 119074, Singapore"
            },
            {
                "name": "Khay Guan Yeoh",
                "org": "Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Hospital System, Singapore 119260, Singapore"
            }
        ],
        "venue": "Biosensors & bioelectronics",
        "year": 2010
    },
    "iM7ZwvbM": {
        "id": "iM7ZwvbM",
        "title": "Image-Guided Real-Time Raman Endoscopy for In Vivo Diagnosis of Gastric Precancer and Cancer During Clinical Gastroscopy",
        "abstract": "",
        "keywords": [
            "real time"
        ],
        "authors": [
            {
                "name": "Mads Sylvest Bergholt",
                "org": ""
            },
            {
                "name": "Wei Zheng",
                "org": ""
            },
            {
                "name": "Kan Lin",
                "org": ""
            },
            {
                "name": "Khek Yu Ho",
                "org": ""
            },
            {
                "name": "Ming Teh",
                "org": ""
            },
            {
                "name": "Khay Guan Yeoh",
                "org": ""
            },
            {
                "name": "Bok Yan J. So",
                "org": ""
            },
            {
                "name": "Zhiwei Huang",
                "org": ""
            }
        ],
        "venue": "Gastroenterology",
        "year": 2011
    },
    "dKZzNY0y": {
        "authors": [
            {
                "name": "Z. Cao",
                "org": "School of Electrical Engineering and Automation, Tianjin University"
            },
            {
                "name": "H. Wang",
                "org": "School of Electrical Engineering and Automation, Tianjin University"
            },
            {
                "name": "S. Liu",
                "org": "North China Electric Power University"
            }
        ],
        "title": "The study of a 2D model for dual mode excitation electrical impedance tomography",
        "abstract": "The task of electrical impedance tomography (EIT) is to recover information about cross-sectional material distribution in the form of reconstructed images by using electrical measurements on the boundary of the interested region. It has several advantages over other tomographic techniques, e.g. low-cost, rapid response, portability, non-invasion and robustness. However, it is not easy to extract impedance information simultaneously over the same cross section. In the literature, researchers proposed mainly a strategy based on a combination of ERT and ECT sensors alternatively over the same cross-section of the interested area, and in this design, the information of resistance and capacitance is obtained sequentially, since the ERT sensor and ECT sensor are used sequentially. This means that impedance information is extracted in a time-sharing method, at the risk of either hardware complexity or information fusion difficulty, because each mode operates in its own way and is limited to resistive or capacitive measurement range only. In this paper, a 2D model has been established to obtain impedance information of resistive as well as capacitive modes simultaneously. Based on the model, the measurement can be performed in either two-port measurement strategy or four-port measurement strategy. Meanwhile, the sensor described in the model is self-calibrated. Thus it can be used to a variety of industry fields and is not just limited to the tomography techniques. Based on the model, the sensor can be designed in other shapes, such as a rectangle, triangle, etc, using the conformal transformation. Images are constructed using Tikhonov regularization based on the sensitivity theorem.",
        "keywords": [
            "2D model",
            "Conformal transformation",
            "Dual mode",
            "Impedance sensor"
        ],
        "venue": "5th World Congress in Industrial Process Tomography",
        "year": 2007,
        "id": "dKZzNY0y"
    },
    "ak3Lf6IE": {
        "id": "ak3Lf6IE",
        "title": "Axiomatic Approaches to Information Retrieval - University of Delaware at TREC 2009 Million Query and Web Tracks",
        "abstract": "We report our experiments in TREC 2009 Million Query track and Adhoc task of Web track. Our goal is to evaluate the effectiveness of axiomatic retrieval models on the large data collection. Axiomatic approaches to information retrieval have been recently proposed and studied. The basic idea is to search for retrieval functions that can satisfy all the reasonable retrieval constraints. Previous studies showed that the derived basic axiomatic retrieval functions are less sensitive to the parameters than the other state of the art retrieval functions with comparable optimal performance. In this paper, we focus on evaluating the effectiveness of the basic axiomatic retrieval functions as well as the semantic term matching based query expansion strategy. Experiment results of the two tracks demonstrate the effectiveness of the axiomatic retrieval models.",
        "keywords": [
            "information retrieval",
            "functions",
            "data acquisition",
            "query expansion",
            "satisfiability"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Department of Electrical and Computer Engineering|University of Delaware"
            },
            {
                "name": "Hui Fang",
                "org": "Department of Electrical and Computer Engineering|University of Delaware"
            }
        ],
        "venue": "TREC",
        "year": 2009
    },
    "0BKaGyi5": {
        "id": "0BKaGyi5",
        "title": "Diversifying Search Results through Pattern-Based Subtopic Modeling",
        "abstract": "Traditional information retrieval models do not necessarily provide users with optimal search experience because the top ranked documents may contain excessively redundant information. Therefore, satisfying search results should be not only relevant to the query but also diversified to cover different subtopics of the query. In this paper, the authors propose a novel pattern-based framework to diversify search results, where each pattern is a set of semantically related terms covering the same subtopic. They first apply a maximal frequent pattern mining algorithm to extract the patterns from retrieval results of the query. The authors then propose to model a subtopic with either a single pattern or a group of similar patterns. A profile-based clustering method is adapted to group similar patterns based on their context information. The search results are then diversified using the extracted subtopics. Experimental results show that the proposed pattern-based methods are effective to diversify the search results.",
        "keywords": [
            "pattern-based subtopic modeling",
            "different subtopics",
            "traditional information retrieval model",
            "context information",
            "diversifying search results",
            "redundant information",
            "maximal frequent pattern mining",
            "optimal search experience",
            "satisfying search result",
            "similar pattern",
            "single pattern",
            "search result"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA"
            },
            {
                "name": "Hui Fang",
                "org": "Department of Electrical and Computer Engineering, University of Delaware, Newark, DE, USA"
            },
            {
                "name": "Hong Cheng",
                "org": "Department of Systems Engineering and Engineering Management, The Chinese University of Hong Kong, Shatin, NT, Hong Kong"
            },
            {
                "name": "Xuanhui Wang",
                "org": "Facebook, Menlo Park, CA, USA"
            }
        ],
        "venue": "Int. J. Semantic Web Inf. Syst.",
        "year": 2012
    },
    "aYiQmabI": {
        "id": "aYiQmabI",
        "title": "Coverage-based search result diversification",
        "abstract": "Traditional retrieval models may provide users with less satisfactory search experience because documents are scored independently and the top ranked documents often contain excessively redundant information. Intuitively, it is more desirable to diversify search results so that the top-ranked documents can cover different query subtopics, i.e., different pieces of relevant information. In this paper, we study the problem of search result diversification in an optimization framework whose objective is to maximize a coverage-based diversity function. We first define the diversity score of a set of search results through measuring the coverage of query subtopics in the result set, and then discuss how to use them to derive diversification methods. The key challenge here is how to define an appropriate coverage function given a query and a set of search results. To address this challenge, we propose and systematically study three different strategies to define coverage functions. They are based on summations, loss functions and evaluation measures respectively. Each of these coverage functions leads to a result diversification method. We show that the proposed coverage based diversification methods not only cover several state-of-the-art methods but also allows us to derive new ones. We compare these methods both analytically and empirically. Experiment results on two standard TREC collections show that all the methods are effective for diversification and the new methods can outperform existing ones.",
        "keywords": [
            "Information retrieval",
            "Diversification",
            "Coverage",
            "Subtopic"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "University of Delaware, 209 Evans Hall, Newark, USA 19716"
            },
            {
                "name": "Xuanhui Wang",
                "org": "Yahoo! Labs, Santa Clara, USA 95054"
            },
            {
                "name": "Hui Fang",
                "org": "University of Delaware, 209 Evans Hall, Newark, USA 19716"
            },
            {
                "name": "Hong Cheng",
                "org": "The Chinese University of Hong Kong, Shatin, Hong Kong"
            }
        ],
        "venue": "Inf. Retr.",
        "year": 2012
    },
    "Tp2MvSyr": {
        "id": "Tp2MvSyr",
        "title": "A Diagnostic Study of Search Result Diversification Methods",
        "abstract": "Search result diversification aims to maximize the coverage of different pieces of relevant information in the search results. Many diversification methods have been proposed and studied. However, the advantage and disadvantage of each method still remain unclear. In this paper, we conduct a diagnostic study over two state of the art diversification methods with the goal of identifying the weaknesses of these methods to further improve the performance. Specifically, we design a set of perturbation tests that isolate individual factors, i.e., relevance and diversity, which affect the diversification performance. The test results are expected to provide insights on how well each method deals with these factors in the diversification process. Experimental results suggest that some methods perform better in queries whose originally retrieved documents are more relevant to the query while other methods perform better when the documents are more diversified. We therefore propose methods to combine these existing methods based on the predicted factor of the query. The experimental results show that the combined methods can outperform individual methods on TREC collections.",
        "keywords": [
            "diagnostic study",
            "individual factor",
            "art diversification method",
            "diversification method",
            "existing method",
            "diversification performance",
            "combined method",
            "diversification process",
            "search result diversification",
            "individual method",
            "search result diversification methods",
            "perturbation",
            "diversification"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Department of Electrical and Computer Engineering, University of Delaware, Newark, DE USA"
            },
            {
                "name": "Hui Fang",
                "org": "Department of Electrical and Computer Engineering, University of Delaware, Newark, DE USA"
            }
        ],
        "venue": "ICTIR",
        "year": 2013
    },
    "PnL4NJ1k": {
        "id": "PnL4NJ1k",
        "title": "Query aspect based term weighting regularization in information retrieval",
        "abstract": "Traditional retrieval models assume that query terms are independent and rank documents primarily based on various term weighting strategies including TF-IDF and document length normalization. However, query terms are related, and groups of semantically related query terms may form query aspects. Intuitively, the relations among query terms could be utilized to identify hidden query aspects and promote the ranking of documents covering more query aspects. Despite its importance, the use of semantic relations among query terms for term weighting regularization has been under-explored in information retrieval. In this paper, we study the incorporation of query term relations into existing retrieval models and focus on addressing the challenge, i.e., how to regularize the weights of terms in different query aspects to improve retrieval performance. Specifically, we first develop a general strategy that can systematically integrate a term weighting regularization function into existing retrieval functions, and then propose two specific regularization functions based on the guidance provided by constraint analysis. Experiments on eight standard TREC data sets show that the proposed methods are effective to improve retrieval accuracy.",
        "keywords": [
            "retrieval accuracy",
            "term weighting regularization",
            "information retrieval",
            "retrieval performance",
            "different query aspect",
            "semantically related query term",
            "query term",
            "query aspect",
            "retrieval model",
            "retrieval function",
            "query term relation"
        ],
        "authors": [
            {
                "name": "Wei Zheng",
                "org": "Department of Electrical and Computer Engineering, University of Delaware"
            },
            {
                "name": "Hui Fang",
                "org": "Department of Electrical and Computer Engineering, University of Delaware"
            }
        ],
        "venue": "ECIR",
        "year": 2010
    },
    "G7sQDyx0": {
        "authors": [
            {
                "name": "Shufeng Sun",
                "org": "School of mechanical and electrical engineering Wenzhou University"
            },
            {
                "name": "Pingping Wang",
                "org": "School of mechanical and electrical engineering Wenzhou University"
            },
            {
                "name": "Xin Wu",
                "org": "School of mechanical and electrical engineering Wenzhou University"
            },
            {
                "name": "Sen Lin",
                "org": "School of mechanical and electrical engineering Wenzhou University"
            }
        ],
        "title": "NC turning process parameters optimization based on simulation software",
        "abstract": "Machining process parameters are main factors influencing machining quality and efficiency. Finite element models of tool and part are set up using finite element software Deform-3D. Variety laws of cutting force and temperature under different process parameters are simulated. The results are analyzed. Cutting force grows obviously with the growth of cutting speed (v",
        "keywords": [
            "Cutting force",
            "Process parameter",
            "Simulation software",
            "Temperature"
        ],
        "venue": "Applied Mechanics and Materials",
        "year": 2013,
        "id": "G7sQDyx0"
    },
    "R7gE7sS9": {
        "authors": [
            {
                "name": "Shufeng Sun",
                "org": "School of Mechanical and Electrical Engineering"
            },
            {
                "name": "Shiming Ji",
                "org": "Key Lab. of Special Purpose Equipment and Advanced Processing Technology of Ministry of Education"
            },
            {
                "name": "Dapeng Tan",
                "org": "Key Lab. of Special Purpose Equipment and Advanced Processing Technology of Ministry of Education"
            },
            {
                "name": "Wei Xue",
                "org": "School of Mechanical and Electrical Engineering"
            },
            {
                "name": "Xin Wu",
                "org": "School of Mechanical and Electrical Engineering"
            }
        ],
        "title": "Abrasive assisted EDM & ECM compound machining",
        "abstract": "The rapid development of micro electromechanical systems (MEMS) and the miniaturization trend of products require much higher machining quality for micro structural surfaces such as micro hole, micro groove and micro prism/pyramid and so on. In order to improve the machining quality of micro structural surfaces, a new method of abrasive assisted electro discharge machining (EDM) and electro chemical machining (ECM) compound machining is provided. The machining mechanism is analyzed by its micro machining model. Micro machining equipment is set up. Process parameters are optimized. Blind and through holes are drilled on SUS 304 stainless steel using tungsten electrodes whose diameters are 500 \u03bcm and 75 \u03bcm separately. The results indicate that abrasive assisted EDM & ECM compound machining obtains the highest surface roughness (Ra15 nm) among the three methods of EDM, EDM & ECM compound machining and abrasive assisted EDM & ECM compound machining. Therefore, this is one of the best methods which can be used to machining micro structural surfaces with high efficiency and high quality.",
        "keywords": [
            "Electro chemical machining",
            "Electro discharge machining",
            "Structural surfaces"
        ],
        "venue": "Jixie Gongcheng Xuebao/Journal of Mechanical Engineering",
        "year": 2012,
        "id": "R7gE7sS9"
    },
    "5CaAB5W4": {
        "authors": [
            {
                "name": "Y. Liu",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "H. Gao",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "H. Liu",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "C. Duan",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "J. Lin",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "Y. Guo",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "X. Liu",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "G. Huang",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "J. Li",
                "org": "State Key Lab. of Magnetic Reson."
            },
            {
                "name": "F. Li",
                "org": "State Key Lab. of Magnetic Reson."
            }
        ],
        "title": "A novel differential velocity modulation laser spectroscopy",
        "abstract": "Experimental investigation of a novel differential velocity modulation laser spectroscopy is reported and demonstrated with the spectra of N",
        "keywords": [
            "Differential technique",
            "Molecular spectroscopy",
            "Velocity modulation"
        ],
        "venue": "Chinese Science Bulletin",
        "year": 2001,
        "id": "5CaAB5W4"
    },
    "Nnw4mt7T": {
        "authors": [
            {
                "name": "Y. Liu",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "X. Liu",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "H. Liu",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "Y. Guo",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "G. Huang",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "J. Lin",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "H. Gao",
                "org": "State Key Lab. of Magnetic Resonance"
            },
            {
                "name": "C. Duan",
                "org": "State Key Lab. of Magnetic Resonance"
            }
        ],
        "title": "Spectroscopic analysis of asymmetric top free radicals - Application to pure rotational spectra of NO",
        "abstract": "Several key problems involved in the analyses of spectra of asymmetric top molecules,i.e., the effective Hamiltonian, the representation and basis vector, identification of energy levels, the selection rules, the relative intensity, and Zeeman tuning rate, were elucidated systematically. Introducing the high-order centrifugal distortion terms into the effective Hamiltonian, the precision for calculation has been improved substantially, which allows us to analyze the high-lying rotational transitions. A global analysis of all available spectra of ",
        "keywords": [
            "Asymmetric top free radical",
            "High-order centrifugal distortion",
            "Spectroscopic analysis of NO2"
        ],
        "venue": "Science in China, Series C: Life Sciences",
        "year": 2001,
        "id": "Nnw4mt7T"
    },
    "zWNZI5yg": {
        "id": "zWNZI5yg",
        "title": "Quality Variety of Evodia rutaecarpa (Juss.) Benth.var. bodinieri (Dode) Huang Ethanol Extracts with Different Drying Methods",
        "abstract": "Objective:To investigate the effect on extracs quality of Evodia rutaecarpa(Juss.)Benth.var.bodinieri(Dode)Huang with different drying methods.Method: Study on compared HPLC and TLC of Evodia alkaloids with different drying methods.Result:The peaks' type and number of different drying methods extracts was same,slight differences in the content of Evodia alkaloids.Conclusion:The chemical composition and character prints of dried extracts in different ways were equal.Energy-conserved,low-cost methods should be selected as practical application.",
        "keywords": [
            "HPLC",
            "different drying methods",
            "evodia alkaloids",
            "Evodia rutaecarpa(Juss.)Benth.var.bodinieri(Dode)Huang",
            "TLC"
        ],
        "authors": [
            {
                "name": "ZHANG Li-yan",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "YANG Wei-ping",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "WANG Hui",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "YANG Yu-qin",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "LI Jian",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "ZHANG Li-li",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "CHEN Xin-hua",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2011
    },
    "17ktemjP": {
        "id": "17ktemjP",
        "title": "Quality Comparison Research on the Flavonoids Ingredients of the Miao Medicine Lysionotus Pauciflorus Maxim. in Guizhou",
        "abstract": "Objective:Study on the Dynamic Change of Guizhou's different origin,different harvest period,different processing methods Lysionotus pauciflorus Maxim.'s nevadensin,in order to provide the basis for the Lysionotus pauciflorus Maxim.quality standard of ascension.Methods:HPLC methods and ultraviolet spectrophotometry were used to determine the contents of Lysionotus pauciflorus Maxim.'s nevadensin and flavonoids.Results:In the different processing the different harvest period and the different origin Lysionotus pauciflorus Maxim.,the contents of nevadensin and flavonoids were quite different.Conclusion:The results can provide the basis for the GAP and the Lysionotus pauciflorus Maxim.quality standard of ascension.",
        "keywords": [
            "Flavonoids",
            "Lysionotus pauciflorus Maxim.",
            "Guizhou",
            "Nevadensin"
        ],
        "authors": [
            {
                "name": "LI Yan",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "ZHANG Li-yan",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "YANG Yu-qin",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "LI Man-ping",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "WANG Hui",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            }
        ],
        "venue": "Modern Chinese Medicine",
        "year": 2011
    },
    "kd5upPpE": {
        "id": "kd5upPpE",
        "title": "Effect of Evodia Rutaecarpa Extract on Hemodynamics of Rats with Acute Myocardial Ischemia",
        "abstract": "Objective: To observe the effect of Evodia Rutaecarpa Extract on hemodynamics of rats with acute myocardial ischemia.Methods: 24 acute myocardial ischemia model rats prepared with clipping trachea methods were randomly divided into the blank control group,model group,Evodia Rutaecarpa water extract group,Evodia Rutaecarpa extractum group,6 in each group.Hemodynamic parameters of heart rate(HR),left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),left ventricular pressure maximum rising and falling rate(\u00b1dp/dtm) were measured.Results: HR,LVSP,+dp/dtm,-dp/dtm levels of Evodia Rutaecarpa water extract group,Evodia Rutaecarpa extractum group were higher than those in the model group,LVEDP level was lower than that of model group(P<0.05 or P<0.01).Conclusion: Evodia Rutaecarpa extract has certain protective effect on the heart function of rats with acute myocardial ischemia.",
        "keywords": [
            "Evodia Rutaecarpa extract",
            "cardiopulmonary resuscitation",
            "hemodynamics",
            "rats",
            "acute myocardial ischemia"
        ],
        "authors": [
            {
                "name": "Zhang Jie",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang,Guizhou,"
            },
            {
                "name": "Peng Fang",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang,Guizhou,"
            },
            {
                "name": "Wang Hui",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang,Guizhou,"
            },
            {
                "name": "Yang Weiping",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang,Guizhou,"
            }
        ],
        "venue": "Henan Traditional Chinese Medicine",
        "year": 2012
    },
    "5bm7YXDX": {
        "id": "5bm7YXDX",
        "title": "Comparative Research Quality of Saxifraga stolonifera in Guizhou",
        "abstract": "Objective:Gallic acid of Saxifraga stolonifera in Guizhou was determined by HPLC.The difference of the quality of S.stolonifera in Guizhou was studied by the current quality criteria of S.stolonifera.It aims at providing a technological basis of improving the method of controlling the quality of S.stolonifera and the standardi-zation planting.Method:The content of bergenin and gallic acid in S.stolonifera was determined by HPLC.Result: The content of bergenin of S.stolonifera was higher than 0.080%,the minimum of current quality criteria,and the average content of gallic acid was 0.121%.The content of bergenin and gallic acid in S.stolonifera was different from various habitats,various collection time and various processing methods.Conclusion: The quality of S.stolonifera was evaluated by using various componential indices and to provide a standardized planting technological basis for GAP and improve the method of quality control of S.stolonifera.",
        "keywords": [
            "HPLC",
            "bergenin",
            "Saxifraga stolonifera",
            "gallic acid"
        ],
        "authors": [
            {
                "name": "ZHANG Li-yan",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "LI Yan",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "YANG Yu-qin",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "XU Chang-yan",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            },
            {
                "name": "WANG Hui",
                "org": "Guiyang College of Traditional Chinese Medicine,Guiyang ,China"
            }
        ],
        "venue": "Chinese Journal of Experimental Traditional Medical Formulae",
        "year": 2010
    },
    "YC65h2rF": {
        "authors": [
            {
                "name": "Jianjun Yu",
                "org": "NEC Laboratories America"
            },
            {
                "name": "Z. Dong",
                "org": "The Key Laboratory for Micro"
            },
            {
                "name": "W. Jian",
                "org": "Key Laboratory of Optical Communication"
            },
            {
                "name": "M.-F. Huang",
                "org": "NEC Laboratories America"
            },
            {
                "name": "Z. Jia",
                "org": "School of Electrical and Computer Engineering"
            },
            {
                "name": "X. Xin",
                "org": "Key Laboratory of Optical Communication"
            },
            {
                "name": "G.-K. Chang",
                "org": "School of Electrical and Computer Engineering"
            },
            {
                "name": "T. Wang",
                "org": "NEC Laboratories America"
            }
        ],
        "title": "All-optical up-conversion 10-Gb/s signal in 60-GHz ROF system using 2-m bismuth oxide-based fiber",
        "abstract": "All-optical up-conversion based on dual-pump four-wave mixing (FWM) in 2-m Bismuth Oxide-based fiber for 10-Gb/s OOK wireless signals in 60-GHz ROF systems has been experimentally demonstrated for the first time. \u00a9 2010 Optical Society of America.",
        "keywords": [
            ""
        ],
        "venue": "Optics InfoBase Conference Papers",
        "year": 2010,
        "id": "YC65h2rF"
    },
    "LlPIXsNK": {
        "authors": [
            {
                "name": "Manuela Lunz",
                "org": ""
            },
            {
                "name": "Xia Zhang",
                "org": ""
            },
            {
                "name": "Valerie A. Gerard",
                "org": ""
            },
            {
                "name": "Yurii K. Gun'Ko",
                "org": ""
            },
            {
                "name": "Vladimir Lesnyak",
                "org": ""
            },
            {
                "name": "Nikolai Gaponik",
                "org": ""
            },
            {
                "name": "Andrei S. Susha",
                "org": ""
            },
            {
                "name": "Andrey L. Rogach",
                "org": ""
            },
            {
                "name": "A. Louise Bradley",
                "org": ""
            }
        ],
        "title": "Effect of metal nanoparticle concentration on localized surface plasmon mediated F\u00f6rster resonant energy transfer",
        "abstract": "The influence of gold nanoparticle concentration on signatures of localized surface plasmon mediated F\u00f6rster resonant energy transfer is investigated in a quantum dot-gold nanoparticle sandwich structure. At lower gold nanoparticle concentrations, localized surface plasmon mediated F\u00f6rster resonant energy transfer enhancement of the acceptor emission is observed. At higher gold nanoparticle concentrations, the acceptor emission is reduced despite faster localized surface plasmon enhanced F\u00f6rster resonant energy transfer rates being achieved. This is attributed to competition between localized surface plasmon mediated F\u00f6rster resonant energy transfer and gold nanoparticle quenching effects. \u00a9 2012 American Chemical Society.",
        "keywords": [
            ""
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2012,
        "id": "LlPIXsNK"
    },
    "agtAdEjk": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "School of Physics"
            },
            {
                "name": "Cristian A. Marocico",
                "org": "School of Physics"
            },
            {
                "name": "Manuela Lunz",
                "org": "School of Physics"
            },
            {
                "name": "Valerie A. Gerard",
                "org": "School of Chemistry"
            },
            {
                "name": "Yurii K. Gun'Ko",
                "org": "School of Chemistry"
            },
            {
                "name": "Vladimir Lesnyak",
                "org": "Physical Chemistry"
            },
            {
                "name": "Nikolai Gaponik",
                "org": "Physical Chemistry"
            },
            {
                "name": "Andrei S. Susha",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "Andrey L. Rogach",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "A. Louise Bradley",
                "org": "School of Physics"
            }
        ],
        "title": "Wavelength, concentration, and distance dependence of nonradiative energy transfer to a plane of gold nanoparticles",
        "abstract": "Nonradiative energy transfer to metal nanoparticles is a technique used for optical-based distance measurements which is often implemented in sensing. Both F\u00f6rster resonant energy transfer (FRET) and nanometal surface energy transfer (NSET) mechanisms have been proposed for emission quenching in proximity to metal nanoparticles. Here quenching of emission of colloidal quantum dots in proximity to a monolayer of gold nanoparticles is investigated. Five differently sized CdTe quantum dots are used to probe the wavelength dependence of the quenching mechanism as their emission peak moves from on resonance to off resonance with respect to the localized surface plasmon peak of the gold nanoparticle layer. The gold nanoparticle concentration and distance dependences of energy transfer are discussed. Photoluminescence quenching and lifetime data are analyzed using both FRET and NSET models and the extracted characteristic distances are compared with theory. Good agreement with FRET theory has been found for quantum dots with emission close to the localized surface plasmon resonance, though larger than expected F\u00f6rster radii are observed for quantum dots with emission red-shifted with respect to the localized surface plasmon peak. Closer agreement between experimental and theoretical characteristic distances can be found across the full wavelength range within a NSET approach. \u00a9 2012 American Chemical Society.",
        "keywords": [
            "fluorescence quenching",
            "Forster resonance energy transfer",
            "gold nanoparticles",
            "nanometal surface energy transfer",
            "quantumdots",
            "surface plasmons"
        ],
        "venue": "ACS Nano",
        "year": 2012,
        "id": "agtAdEjk"
    },
    "5evs5xZj": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "Semiconductor Photonics Group"
            },
            {
                "name": "Valerie A. Gerard",
                "org": "School of Chemistry"
            },
            {
                "name": "Yurii K. Gun'Ko",
                "org": "School of Chemistry"
            },
            {
                "name": "Vladimir Lesnyak",
                "org": "Physical Chemistry"
            },
            {
                "name": "Nikolai Gaponik",
                "org": "Physical Chemistry"
            },
            {
                "name": "Andrei S. Susha",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "Andrey L. Rogach",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "A. Louise Bradley",
                "org": "Semiconductor Photonics Group"
            }
        ],
        "title": "Large energy transfer distance to a plane of gold nanoparticles",
        "abstract": "The quenching of emission in proximity to metallic surfaces via non-radiative energy transfer is studied for sensing applications. It can also be used for the measurement of distances on the nanoscale. We report on energy transfer from a plane of CdTe quantum dots (QDs) plane to a plane of gold (Au) nanoparticles. Both photoluminescence (PL) and luminescence lifetime measurements demonstrate that energy transfer efficiency not only depends on plane separation but also Au nanoparticle concentration. Energy transfer to the plane of metal nanoparticles can be considered within the standard F\u00f6rster resonant energy transfer (FRET) model or the nano-metal surface energy transfer (NSET) model. It is found that both dependences are well described within the model of FRET which shows a 1/d ",
        "keywords": [
            "Au nanoparticles",
            "F\u00f6rster resonant energy transfer",
            "nanocrystal quantum dots",
            "surface plasmons",
            "time-resolved emission decay"
        ],
        "venue": "International Conference on Transparent Optical Networks",
        "year": 2012,
        "id": "5evs5xZj"
    },
    "oTxkIo4H": {
        "authors": [
            {
                "name": "Manuela Lunz",
                "org": "Semiconductor Photonics Group"
            },
            {
                "name": "Xia Zhang",
                "org": "Semiconductor Photonics Group"
            },
            {
                "name": "Valerie A. Gerard",
                "org": "School of Chemistry"
            },
            {
                "name": "Yurii K. Gun'Ko",
                "org": "School of Chemistry"
            },
            {
                "name": "Vladimir Lesnyak",
                "org": "Physical Chemistry"
            },
            {
                "name": "Nikolai Gaponik",
                "org": "Physical Chemistry"
            },
            {
                "name": "Andrei S. Susha",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "Andrey L. Rogach",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "A. Louise Bradley",
                "org": "Semiconductor Photonics Group"
            }
        ],
        "title": "Modification of the FRET rate in quantum dot structures",
        "abstract": "Frster resonant energy transfer (FRET) can be applied to create energy flow on the nano-scale for lightharvesting, colour conversion or sensing applications. The performance of such devices depends on the efficiency of the energy transfer process between the donors and acceptors. In order to achieve high FRET efficiencies, the FRET rate has to dominate over the other donor decay rates. The FRET rate depends on the donor-acceptor separation, the acceptor concentration and it has also been proposed that it can be strongly enhanced by localized surface plasmons supported by metal nanoparticles. The impact of these different parameters on the FRET rate in a CdTe quantum dot donor-acceptor bilayer structure is presented. The quantum dot structures, prepared by a layer-by-layer deposition technique, were characterized by steady-state photoluminescence (PL) and absorption spectroscopy as well as time-resolved PL measurements. The FRET rate of the different structures was determined from the time-resolved donor PL decays and its separation and concentration dependence was compared with FRET theory. \u00a9 2011 IEEE.",
        "keywords": [
            "colloidal gold nanoparticles",
            "F\u00f6rster resonant energy transfer",
            "localized surface plasmon resonances",
            "nanocrystal quantum dots",
            "time-resolved emission decay"
        ],
        "venue": "International Conference on Transparent Optical Networks",
        "year": 2011,
        "id": "oTxkIo4H"
    },
    "tMK1sZ0F": {
        "authors": [
            {
                "name": "Xia Zhang",
                "org": "School of Physics and CRANN"
            },
            {
                "name": "Cristian A. Marocico",
                "org": "School of Physics and CRANN"
            },
            {
                "name": "Manuela Lunz",
                "org": "Research Laboratories"
            },
            {
                "name": "Valerie A. Gerard",
                "org": "School of Chemistry and CRANN"
            },
            {
                "name": "Yurii K. Gun'Ko",
                "org": "School of Chemistry and CRANN"
            },
            {
                "name": "Vladimir Lesnyak",
                "org": "Istituto Italiano di Tecnologia"
            },
            {
                "name": "Nikolai Gaponik",
                "org": "Physical Chemistry"
            },
            {
                "name": "Andrei S. Susha",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "Andrey L. Rogach",
                "org": "Department of Physics and Materials Science"
            },
            {
                "name": "A. Louise Bradley",
                "org": "School of Physics and CRANN"
            }
        ],
        "title": "Experimental and theoretical investigation of the distance dependence of localized surface plasmon coupled f\u00f6rster resonance energy transfer",
        "abstract": "The distance dependence of localized surface plasmon (LSP) coupled F\u00f6rster resonance energy transfer (FRET) is experimentally and theoretically investigated using a trilayer structure composed of separated monolayers of donor and acceptor quantum dots with an intermediate Au nanoparticle layer. The dependence of the energy transfer efficiency, rate, and characteristic distance, as well as the enhancement of the acceptor emission, on the separations between the three constituent layers is examined. A d ",
        "keywords": [
            "colloidal metal nanoparticles",
            "F\u00f6rster resonant energy transfer",
            "localized surface plasmons",
            "nanocrystals",
            "nonradiative energy transfer",
            "quantum dots"
        ],
        "venue": "ACS Nano",
        "year": 2014,
        "id": "tMK1sZ0F"
    },
    "wMhFFxYx": {
        "authors": [
            {
                "name": "Xiang Wang",
                "org": "National Engineering Laboratory for Coal-Fired Pollutants Emission Reduction, Shandong University"
            },
            {
                "name": "Xujiang Wang",
                "org": "National Engineering Laboratory for Coal-Fired Pollutants Emission Reduction, Shandong University"
            },
            {
                "name": "Yanrong Fan",
                "org": "National Engineering Laboratory for Coal-Fired Pollutants Emission Reduction, Shandong University"
            },
            {
                "name": "Zhiqiang Wang",
                "org": "National Engineering Laboratory for Coal-Fired Pollutants Emission Reduction, Shandong University"
            }
        ],
        "title": "Pyrolysis characteristics and kinetics parameters of diesel under different atmosphere",
        "abstract": "The pyrolysis process of diesel was investigated via thermo-gravimetric analysis at different heating rates, atmosphere and gas rates. Compared with the single reaction energy model, the distribution activation energy model(DAEM) is more applicable to the analysis of diesel pyrolysis. The results indicate that the single reaction energy model can not predict the pyrolysis characteristics of diesel within the whole experimental temperature range. While activation energy and pre-exponential factors can be obtained by the DAEM model on the basis of 3 thermogravimetric curves at different heating rates, which are more accurate and acceptable. The curve of activation energy from DAEM model under different atmosphere shows that the diesel is more stable in CO",
        "keywords": [
            "Diesel",
            "Distribution activation",
            "energy model (DAEM)",
            "Kinetics parameters",
            "Pyrolysis characteristics",
            "Thermo-gravimetric"
        ],
        "venue": "Ranshao Kexue Yu Jishu/Journal of Combustion Science and Technology",
        "year": 2014,
        "id": "wMhFFxYx"
    },
    "DxAHVfow": {
        "id": "DxAHVfow",
        "title": "Notes on Prosopocoilus hope (Coleoptera: Scarabaeoidea: Lucanidae) from China, with the description of two new species",
        "abstract": "Prosopocoilus yangi Fukinuki has been rediscovered from central China and is redescribed with male and female genitalia illustrated. A similar species, P. simianshanus new species, is described from Chongqing, central China. Prosopocoilus reni new species is described from Hainan, China. Taxonomic notes are given for Kirchnerius guangxii Schenk, Prosopocoilus astacoides (Hope) and Prosopocoilus duplodentatus Benesh. Three new synonyms are presented: Prosopocoilus Hope = Kirchnerius Schenk new synonym; Prosopocoilus cyclommatoides Lacroix = Kirchnerius guangxii Schenk new synonym; Prosopocoilus oweni melli Kriesche = Prosopocoilus duplodentatus Benesh new synonym. \u00a9 2011.Magnolia Press.",
        "keywords": [
            "China",
            "Kirchnerius",
            "Lucanidae",
            "New species",
            "New synonym",
            "Prosopocoilus",
            "Redescription"
        ],
        "authors": [
            {
                "name": "Hao Huang",
                "org": ""
            },
            {
                "name": "Chang-Chin Chen",
                "org": ""
            }
        ],
        "venue": "Zootaxa",
        "year": 2011
    },
    "BTXeGK4l": {
        "id": "BTXeGK4l",
        "title": "Notes on the genus Ceruchus MacLeay from China, with the description of a new species (Coleoptera: Scarabaeoidea: Lucanidae)",
        "abstract": "The taxonomy is reviewed for most Chinese species of Ceruchus. New localities are recorded for Ceruchus minor Tanikado & Okuda. Ceruchus yangi Huang, Imura & Chen, sp. nov. is described from Guizhou, China. Morphological characters of most species from China and Japan are studied and summarized into tables. Female genitalia of seven species of Ceruchus are described and illustrated for the first time. A key to males of the Palaearctic species and a key to females of the Chinese and Japanese species are provided. Natural history notes are given for some species from China. Copyright \u00a9 2011. Magnolia Press.",
        "keywords": [
            "Ceruchus",
            "Checklist",
            "China",
            "Identification key",
            "Lucanidae",
            "Morphology",
            "Natural history",
            "New localities",
            "New species"
        ],
        "authors": [
            {
                "name": "Hao Huang",
                "org": ""
            },
            {
                "name": "Y\u00fbki Imura",
                "org": ""
            },
            {
                "name": "Chang-Chin Chen",
                "org": ""
            }
        ],
        "venue": "Zootaxa",
        "year": 2011
    },
    "qTBE6jUo": {
        "id": "qTBE6jUo",
        "title": "Motuotrichius yangi , a new genus and species from southeastern Tibet, China (Coleoptera: Scarabaeidae: Cetoniinae: Trichiini)",
        "abstract": "Motuotrichius yangi,  new genus, new species is described from Motuo, southeastern Tibet.  Motuotrichius  seems to have a mixture of characters observed in the genera  Epitrichius  Tagawa, 1941,  Indotrichius  Krikken, 2009,  Lasiotrichius  Reitter, 1899 ,  and  Trichius  Fabricius, 1775 ,  but is separable from all the known Eurasian genera of Trichiina by the presence of a tooth on the inner side of the mesotibia in both sexes. The habitus, external characters, and male genitalia of  Motuotrichius yangi  are illustrated. The following new combinations are given:  Gnorimotrichius albomaculatus  (Moser, 1902),  Gnorimotrichius signatus  (Chujo, 1940),  Gnorimotrichius trilineatus  (Ma, 1992), and  Gnorimotrichius tronqueti  (Antoine, 2002).",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Huang",
                "org": "503, Unit 1, #1 Dongtinghu Road, Qingdao, P.R. China."
            },
            {
                "name": "Chang-Chin Chen",
                "org": "Technical Center, Tianjin New Wei San Industrial Company, Limited, P.R. China."
            }
        ],
        "venue": "Zootaxa",
        "year": 2016
    },
    "EBnjYvgh": {
        "id": "EBnjYvgh",
        "title": "A review of the genera Prismognathus Motschulsky and Cladophyllus Houlbert (Coleoptera: Scarabaeoidea: Lucanidae) from China, with the description of two new species",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Huang",
                "org": ""
            },
            {
                "name": "Chang-Chin Chen",
                "org": ""
            }
        ],
        "venue": "Zootaxa",
        "year": 2012
    },
    "ADjNhMM8": {
        "id": "ADjNhMM8",
        "title": "<i>Motuotrichius</i> <i>yangi</i>, a new genus and species from southeastern Tibet, China (Coleoptera: Scarabaeidae: Cetoniinae: Trichiini).",
        "abstract": "Motuotrichius yangi, new genus, new species is described from Motuo, southeastern Tibet. Motuotrichius seems to have a mixture of characters observed in the genera Epitrichius Tagawa, 1941, Indotrichius Krikken, 2009, Lasiotrichius Reitter, 1899, and Trichius Fabricius, 1775, but is separable from all the known Eurasian genera of Trichiina by the presence of a tooth on the inner side of the mesotibia in both sexes. The habitus, external characters, and male genitalia of Motuotrichius yangi are illustrated. The following new combinations are given: Gnorimotrichius albomaculatus (Moser, 1902), Gnorimotrichius signatus (Ch\u00fbj\u00f4, 1940), Gnorimotrichius trilineatus (Ma, 1992), and Gnorimotrichius tronqueti (Antoine, 2002).",
        "keywords": [
            "Coleoptera",
            "Trichiina",
            "new combination",
            "Gnorimotrichius"
        ],
        "authors": [
            {
                "name": "Hao Huang",
                "org": "503, Unit 1, #1 Dongtinghu Road, Qingdao, P.R. China.. cmdhhxx@hotmail.com."
            },
            {
                "name": "Chang-Chin Chen",
                "org": ""
            }
        ],
        "venue": "Zootaxa",
        "year": 2016
    },
    "kmR01ch5": {
        "authors": [
            {
                "name": "Hongyu Sun",
                "org": "College of Computer Science and Technology, Jilin University"
            },
            {
                "name": "Zhiyi Fang",
                "org": "College of Computer Science and Technology, Jilin University"
            },
            {
                "name": "Zhiqiang Chen",
                "org": "School of Computer Science and Information Engineering, Chongqing Technology and Business University"
            },
            {
                "name": "Jin He",
                "org": "China Unicom Research Institute"
            }
        ],
        "title": "A scalable uniform localization performance evaluated model and performance analysis of range-free algorithms in WSN",
        "abstract": "In this paper, we investigated and solved two issues in the research of Wireless Sensor Network (WSN). Firstly, we proposed a Scalable Uniform Localization Performance evaluated model (SULP evaluated model). There are two parts of this model, modules and data structures, both of them can be customized and extended by users as they need. By using this model researchers can save more time because they pay more attention to the algorithm itself but not to the evaluate environment and parameters. Secondly, we investigated the impacts of communications radius and anchor node ratio on localization algorithms. Four classical algorithms have been evaluated under the scalable model. Experimental results show that the performance including localization error rate, localization cover rate and energy consumption have different trends when communication radius and anchor node ratio changing in a reasonable range. Finally we concluded the regulars of the trends to provide instructions to industrial applications and other researchers.",
        "keywords": [
            "Localization",
            "Range-free",
            "SULP Evaluated Model",
            "WSN"
        ],
        "venue": "Journal of Information and Computational Science",
        "year": 2015,
        "id": "kmR01ch5"
    },
    "bJRw6kNE": {
        "authors": [
            {
                "name": "Yong Yu",
                "org": "Life Science College"
            },
            {
                "name": "Geng-Fu Xiao",
                "org": "Life Science College"
            },
            {
                "name": "Min Li",
                "org": "Life Science College"
            },
            {
                "name": "Rui Zhan",
                "org": "Life Science College"
            },
            {
                "name": "Wen-Tao Zhang",
                "org": "Life Science College"
            }
        ],
        "title": "Molecular mechanism of the entry of HIV-1 into cells and the related drug research",
        "abstract": "The human immunodeficiency viruses (HIV) cause the destruction of CIM lymphocytes, resulting in the development of acquired immunodeficiency syndrome (AIDS). The entry of HIV into host cells is mainly mediated by the fusion of the viral and cellular membranes, which involves the interactions of a series of biomacromolecules, such as gp120, gp41, CD4 and CCR5. The deep understanding of the crystal structures, the surfactant details of their interaction, and the change of conformation during interaction of the macromolecules provides a new idea for the anti HIV drugs. At present some new drugs have been found arising from this idea.",
        "keywords": [
            "Human immunodeficiency viruses (HIV)",
            "Inhibit",
            "Interactions of molecular"
        ],
        "venue": "Progress in Biochemistry and Biophysics",
        "year": 2003,
        "id": "bJRw6kNE"
    },
    "AB0G5ljV": {
        "id": "AB0G5ljV",
        "title": "The involvement of aquaporin 1 in the hepatopulmonary syndrome rat serum-induced migration of pulmonary arterial smooth muscle cells via the p38-MAPK pathway",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing gao",
                "org": "southwest general health center"
            },
            {
                "name": "lin chen",
                "org": "southwest general health center"
            },
            {
                "name": "jing zeng",
                "org": "southwest general health center"
            },
            {
                "name": "jian cui",
                "org": "southwest general health center"
            },
            {
                "name": "jiaolin ning",
                "org": "southwest general health center"
            },
            {
                "name": "guansong wang",
                "org": "third military medical university"
            },
            {
                "name": "karine belguise",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "xiaobo wang",
                "org": "centre national de la recherche scientifique"
            },
            {
                "name": "guisheng qian",
                "org": "third military medical university"
            },
            {
                "name": "kaizhi lu",
                "org": "southwest general health center"
            },
            {
                "name": "bin yi",
                "org": "southwest general health center"
            }
        ],
        "venue": "Molecular BioSystems",
        "year": 2015
    },
    "mwkuxiz8": {
        "id": "mwkuxiz8",
        "title": "Loss of cell polarity regulated by PTEN/Cdc42 enrolled in the process of Hepatopulmonary Syndrome.",
        "abstract": "One central factor in hepatopulmonary syndrome (HPS) pathogenesis is pulmonary vascular remodelling (PVR) which involves dysregulation of proliferation and migration in pulmonary microvascular endothelial cells (PMVECs). Growing evidence suggests that Apical/basolateral polarity plays an important role in cell proliferation, migration, adhesion and differentiation. In this study, we explored whether cell polarity is involved and critical in experimental HPS rats that are induced by common bile duct ligation (CBDL). Cell polarity related proteins were analysed in CBDL rats lung and PMVECs under the HPS serum stimulation by immunofluorescence assay. Cdc42/PTEN activity, cell proliferation and migration and Annexin A2 (AX2) in PMVECs were determined, respectively. Cell polarity related proteins, lost their specialized luminal localization in PMVECs of the CBDL rat. The loss of cell polarity was induced by abnormal activity of Cdc42, which was strongly enhanced by the interaction between p-PTEN and Annexin A2 in PMVECs, after treatment with serum from CBDL rats. It led to over-proliferation and high migration ability of PMVECs. Down-regulation of PTEN-Cdc42 activity in PMVECs restored cell polarity and thus reduced their ability of migration and proliferation. Our study suggested that the loss of cell polarity plays a critical role in the pathogenesis of HPS-associated PVR and may become a potentially effective therapeutic target.",
        "keywords": [
            "Cdc42",
            "Hepatopulmonary Syndrome",
            "PMVEC",
            "PTEN",
            "cell polarity"
        ],
        "authors": [
            {
                "name": "Jing Gao",
                "org": "Department of Anaesthesia, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China."
            },
            {
                "name": "Hongfu Yu",
                "org": "Department of Anaesthesia, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China."
            },
            {
                "name": "Xuehong Bai",
                "org": "Department of Anaesthesia, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China."
            },
            {
                "name": "Chang Liu",
                "org": "Department of Anaesthesia, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China."
            },
            {
                "name": "Lin Chen",
                "org": "Department of Anaesthesia, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China."
            },
            {
                "name": "Karine Belguise",
                "org": "LBCMCP, Centre de Biologie Int\u00e9grative (CBI), Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse, France."
            },
            {
                "name": "Xiaobo Wang",
                "org": "LBCMCP, Centre de Biologie Int\u00e9grative (CBI), Universit\u00e9 de Toulouse, CNRS, UPS, Toulouse, France."
            },
            {
                "name": "Kaizhi Lu",
                "org": "Department of Anaesthesia, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China."
            },
            {
                "name": "Zhiyong Hu",
                "org": "Department of Anaesthesia, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China."
            },
            {
                "name": "Bin Yi",
                "org": "Department of Anaesthesia, Southwest Hospital, The Third Military Medical University (Army Medical University), Chongqing, China."
            }
        ],
        "venue": "Journal of cellular and molecular medicine",
        "year": 2019
    },
    "H5M3Qpbk": {
        "id": "H5M3Qpbk",
        "title": "Annexin A2-modulated proliferation of pulmonary arterial smooth muscle cells depends on caveolae and caveolin-1 in hepatopulmonary syndrome",
        "abstract": "We have established that annexin A2 (ANXA2) is an important factor in the experimental hepatopulmonary syndrome (HPS) serum-induced proliferation of pulmonary arterial smooth muscle cells (PASMCs). However, the detailed mechanism remains unclear. ANXA2 translocated to the caveolin-enriched microdomains (caveolae) in PASMCs upon HPS serum stimulation. The disruption of caveolae by Methyl-\u03b2-cyclodextrin (M\u03b2CD) alleviated the caveolae recruitment of ANXA2 and the ANXA2-mediated activation of ERK1/2 and NF-\u03baB, so that ANXA2-modulated PASMC proliferation was suppressed. The over-expression of Cav-1 resulted in the relocation of ANXA2 from caveolae and negatively regulated ERK1/2 and NF-\u03baB activation, which inhibited the ANXA2-modulated PASMC proliferative behavior. These data indicate that caveolae function as a signaling platform for ANXA2-induced proliferative behavior and Cav-1 participates upstream of ANXA2 in the activation of ERK1/2 and NF-\u03baB.",
        "keywords": "",
        "authors": [
            {
                "name": "Lin Liao",
                "org": "Department of Anesthesia, People's Hospital of Qijiang District, Chongqing 401420, China"
            },
            {
                "name": "Binwu Zheng",
                "org": "Department of Anesthesia, People's Hospital of Rongchang County, Chongqing 402460, China"
            },
            {
                "name": "Bin Yi",
                "org": "Department of Anesthesia, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Chang Liu",
                "org": "Department of Anesthesia, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Lin Chen",
                "org": "Department of Anesthesia, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Ziyang Zeng",
                "org": "Department of Anesthesia, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China"
            },
            {
                "name": "Jing Gao",
                "org": "Department of Anesthesia, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China"
            }
        ],
        "venue": "Experimental Cell Research",
        "year": 2017
    },
    "twVSh1Uj": {
        "authors": [
            {
                "name": "Su-Fang Han",
                "org": "Analysis and Test Center, Zhejiang Forestry Academy"
            },
            {
                "name": "Liang He",
                "org": "Institute of Biotechnology, Zhejiang Forestry Academy"
            },
            {
                "name": "Ya-Qun Liu",
                "org": "Analysis and Test Center, Zhejiang Forestry Academy"
            },
            {
                "name": "Jun-Wen Cheng",
                "org": "Institute of Biotechnology, Zhejiang Forestry Academy"
            },
            {
                "name": "Liu Yang",
                "org": "Zhejiang Forestry Product Testing Station"
            }
        ],
        "title": "Quick determination of \u03b2-glucan from phellinus by fluorometry method",
        "abstract": "Based on the fluorescent property of specific integration of aniline blue dye and laminarin, a fluorescent determination method for quick determination of \u03b2-glucan from Phellinus is developed. The 96 hole state, standard sample, recovery, precision and stability are investigated. With an excitation maximum wavelength of 398 nm and an emission maximum wavelength of 503 nm, there is a good linear relationship between the concentration of laminarin in the range of 0-15 \u03bcg/mL and fluorescent intensity. The content of \u03b2-glucan in Phellinus polysaccharide is 19.86%. The recovery is 98.39%. The commercially available yeast beta glucan content in dextran powder is determined for comparison. Its \u03b2-glucan content is 82.29%, which is consistent with the labeling content of the products.",
        "keywords": [
            "Fluorometry",
            "Phellinus",
            "\u03b2-glucan"
        ],
        "venue": "Xiandai Huagong/Modern Chemical Industry",
        "year": 2014,
        "id": "twVSh1Uj"
    },
    "riKpTjtB": {
        "authors": [
            {
                "name": "Xu-Qun Li",
                "org": "Chaozhou Zerun Pharmaceuticals CO., Ltd."
            },
            {
                "name": "Xi Li",
                "org": "Shantou Chinese Traditional Medical Technical College"
            },
            {
                "name": "Xiao-Cong Shi",
                "org": "Shantou Chinese Traditional Medical Technical College"
            },
            {
                "name": "Fen-Peng Zhang",
                "org": "Chaozhou Zerun Pharmaceuticals CO., Ltd."
            },
            {
                "name": "Lin-Lin Chen",
                "org": "Chaozhou Zerun Pharmaceuticals CO., Ltd."
            }
        ],
        "title": "Tissue culture of vitex agnus-castus L.",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Plant Physiology Communications",
        "year": 2009,
        "id": "riKpTjtB"
    },
    "fj7E2O1I": {
        "authors": [
            {
                "name": "Xu-Qun Li",
                "org": "Shantou Chinese Traditional Medical Technical College"
            },
            {
                "name": "Xi Li",
                "org": "Shantou Chinese Traditional Medical Technical College"
            },
            {
                "name": "Fen-Peng Zhang",
                "org": "Guangdong Chinese Zerun Pharmaceuticals Co. Ltd."
            }
        ],
        "title": "Tissue culture of bacopa monnieri (L.) wettst",
        "abstract": "",
        "keywords": [
            ""
        ],
        "venue": "Plant Physiology Communications",
        "year": 2008,
        "id": "fj7E2O1I"
    },
    "z1oxlA1r": {
        "id": "z1oxlA1r",
        "title": "Anti-proliferative effect of camellianin A in Adinandra nitida leaves and its apoptotic induction in human Hep G2 and MCF-7 cells.",
        "abstract": "Leaves of Adinandra nitida constitute a kind of flavonoid-rich plant food. In this study, camellianin A, the main flavonoid in the leaves of Adinandra nitida,was prepared and identified by high performance liquid chromatography-photodiode array detector-electrospray ionization mass spectrometry (HPLC-PDA-ESI/MS). In the anticancer assay, it was found camellianin A could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treated by camellianin A, phosphatidylserine of Hep G2 and MCF-7 cells could translocate significantly to the surface of the membrane. The increase of an early apoptotic population of Hep G2 and MCF-7 cells was observed. It was concluded that camellianin A not only affected the progress of the cell cycle, but also induced cells to enter into apoptosis.",
        "keywords": [
            "ANTIOXIDANT ACTIVITY",
            "FLAVONOIDS",
            "CHROMATOGRAPHY",
            "DEATH"
        ],
        "authors": [
            {
                "name": "Gao Han",
                "org": ""
            },
            {
                "name": "Liu Benguo",
                "org": ""
            },
            {
                "name": "Liu Feng",
                "org": ""
            },
            {
                "name": "Chen Yongsheng",
                "org": ""
            }
        ],
        "venue": "Molecules (Basel, Switzerland)",
        "year": 2010
    },
    "cPn8h1o9": {
        "id": "cPn8h1o9",
        "title": "Apoptosis induced by the inclusion complex of dihydromyricetin with hydroxypropyl-beta-cyclodextrin in Human Hep G2 cells",
        "abstract": "Dihydromyricetin was a flavonoid with good prospect in food and medicine industry, but its poor water solubility limits its application. By forming the inclusion complex with hydroxypropyl-beta-cyclodextrin, the solubility and stability of dihydromyricetin in water could be significantly improved. In this study, it was found that the complex could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 cells and induce the significant change of cell cycle. After been treated by the complex, phosphatidylserine of Hep G2 could significantly translocate to the surface of the membrane. The increase of an early apoptotic population of Hep G2 cells was observed. It was concluded that the complex not only affected the progress of the cell cycle but also induced cells to enter into apoptosis.",
        "keywords": [],
        "authors": [
            {
                "name": "Yang Jiguo",
                "org": ""
            },
            {
                "name": "Liu Benguo",
                "org": ""
            },
            {
                "name": "Liu Feng",
                "org": ""
            },
            {
                "name": "Zhang Yuan",
                "org": ""
            }
        ],
        "venue": "JOURNAL OF MEDICINAL PLANTS RESEARCH",
        "year": 2011
    },
    "o1vxaEVN": {
        "id": "o1vxaEVN",
        "title": "Supercritical carbon dioxide extraction of ethyl p-methoxycinnamate from Kaempferia galanga L. rhizome and its apoptotic induction in human HepG2 cells.",
        "abstract": "In this study, supercritical carbon dioxide extraction of ethyl p-methoxycinnamate from Kaempferia galanga L. rhizome and its apoptotic induction in human HepG2 cells are reported for the first time. By using supercritical carbon dioxide extraction, the yield of ethyl p-methoxycinnamate identified by gas chromatography mass spectrometry (GC-MS) was as high as 2.5% with respect to the raw materials. In the anticancer assay, it was found that ethyl p-methoxycinnamate could inhibit the proliferation of the human hepatocellular liver carcinoma HepG2 cell line in a dose-dependent manner and induce the significant increase of the subG0 cell population. After treatment with ethyl p-methoxycinnamate, phosphatidylserine of HepG2 cells could significantly translocate to the surface of the membrane. The increase of an early apoptotic population was observed by both annexin-fluorescein isothiocyanate (FITC) and propidium iodide (PI) staining. It was concluded that ethyl p-methoxycinnamate not only induced cells to enter into apoptosis, but also affected the progress of the cell cycle.",
        "keywords": [
            "PATHOGENESIS",
            "ANTIOXIDANT",
            "INHIBITION",
            "TOXICITY",
            "LEAVES",
            "DEATH",
            "ASSAY"
        ],
        "authors": [
            {
                "name": "Liu Benguo",
                "org": ""
            },
            {
                "name": "Liu Feng",
                "org": ""
            },
            {
                "name": "Chen Chungang",
                "org": ""
            },
            {
                "name": "Gao Han",
                "org": ""
            }
        ],
        "venue": "Natural product research",
        "year": 2010
    },
    "tupNtqNw": {
        "id": "tupNtqNw",
        "title": "Synthesis of 4',7-diacetoxyapigenin and its apoptotic induction in human Hep G2 cells.",
        "abstract": "In this study, 4',7-diacetoxyapigenin [4-(7-acetoxy-5-hydroxy-4-oxo-4H-chromen-2-yl) phenyl acetate] was synthesized for the first time. Its chemical structure was identified by UV, ESI-MS, (1)H and (13)C-NMR. It could inhibit the proliferation of Hep G2 cells in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treatment by 4',7-diacetoxyapigenin, phosphatidylserine of Hep G2 cells could significantly translocate to the surface of the membrane. The increase of an early apoptotic population was observed by both annexin-FITC and PI staining. It was concluded that 4',7-diacetoxyapigenin not only induced cells to enter into apoptosis, but also affected the progress of the cell cycle.",
        "keywords": [
            "CANCER",
            "DEATH",
            "APIGENIN",
            "ASSAY"
        ],
        "authors": [
            {
                "name": "Xu Keyong",
                "org": ""
            },
            {
                "name": "Liu Feng",
                "org": ""
            },
            {
                "name": "Liu Benguo",
                "org": ""
            },
            {
                "name": "Gao Han",
                "org": ""
            },
            {
                "name": "Ning Zhengxiang",
                "org": ""
            }
        ],
        "venue": "International journal of molecular sciences",
        "year": 2010
    },
    "MtwzfGMM": {
        "authors": [
            {
                "name": "F. Liu",
                "org": "Beijing Institute of Electronic Technology"
            },
            {
                "name": "Michail Antoniou",
                "org": "School of Electronic, Electrical and Computer Engineering"
            },
            {
                "name": "Z. Zeng",
                "org": "School of Electronic, Electrical and Computer Engineering"
            },
            {
                "name": "M. Cherniakov",
                "org": "School of Electronic, Electrical and Computer Engineering"
            }
        ],
        "title": "Coherent change detection using passive GNSS-based BSAR: Experimental proof of concept",
        "abstract": "This paper presents proof-of-concept methods and results on a passive synthetic aperture radar for surface change monitoring. The bistatic topology comprises navigation satellites (such as Global Positioning System, GLObal Navigation Satellite System (GLONASS), Galileo, or Beidou) as transmitters of opportunity and a fixed receiver on the ground. Surface monitoring is to be provided through coherent change detection. An experimental test bed built to confirm the concept of the system is described, and the appropriate experimental program is presented. Preliminary signal processing algorithms for change detection are derived. Experimentally measured changes are compared to the theoretical predictions, and the obtained results are discussed. \u00a9 1980-2012 IEEE.",
        "keywords": [
            "Bistatic synthetic aperture radar (SAR)",
            "Coherent change detection (CCD)",
            "Passive radar"
        ],
        "venue": "IEEE Transactions on Geoscience and Remote Sensing",
        "year": 2013,
        "id": "MtwzfGMM"
    },
    "yRQoYtfQ": {
        "authors": [
            {
                "name": "M. Antoniou",
                "org": "School of Electronic, Electrical and Computer Engineering"
            },
            {
                "name": "F. Liu",
                "org": "School of Information and Electronics"
            },
            {
                "name": "Z. Zeng",
                "org": "School of Electronic, Electrical and Computer Engineering"
            },
            {
                "name": "V. Sizov",
                "org": "Moscow Institute of Electronic Technology"
            },
            {
                "name": "M. Cherniakov",
                "org": "School of Electronic, Electrical and Computer Engineering"
            }
        ],
        "title": "Coherent change detection using GNSS-based passive SAR: First experimental results",
        "abstract": "This paper reports progress and results in the development of a coherent change detector using passive bistatic SAR. The bistatic topology is Space-Surface Bistatic SAR with Global Navigation Satellite Systems as transmitters of opportunity and a fixed receiver. An experimental test-bed, built to test the feasibility of such a system, is described. Current signal processing algorithms measuring surface change are conceptually explained and the obtained experimental results are presented.",
        "keywords": [
            "Bistatic SAR",
            "Coherent change detection",
            "SS-BSAR"
        ],
        "venue": "IET Conference Publications",
        "year": 2012,
        "id": "yRQoYtfQ"
    },
    "aerfMdvS": {
        "authors": [
            {
                "name": "F. Liu",
                "org": "Electronic Engineering Department"
            },
            {
                "name": "M. Antoniou",
                "org": "School of Electronic, Electrical and Computer Engineering"
            },
            {
                "name": "Z. Zeng",
                "org": "School of Electronic, Electrical and Computer Engineering"
            },
            {
                "name": "M. Cherniakov",
                "org": "School of Electronic, Electrical and Computer Engineering"
            }
        ],
        "title": "Point spread function analysis for BSAR with GNSS transmitters and long dwell times: Theory and experimental confirmation",
        "abstract": "This letter conducts a point spread function (PSF) analysis for bistatic synthetic aperture radar (BSAR) systems where the transmitter is in medium Earth orbit, and the receiver is fixed on the ground. To achieve a reasonable azimuth resolution under such a configuration, the trajectory of the satellite can no longer be approximated as a straight line; therefore, current methods for PSF analysis are insufficient. The solution proposed involves extension of the generalized ambiguity function to accommodate satellite trajectory curvature. The theoretical analysis shows effects unlike those observed in monostatic or even the general BSAR and is verified by both simulation and experimental results using navigation satellites as the transmitting platforms. \u00a9 2012 IEEE.",
        "keywords": [
            "Asymmetric bistatic synthetic aperture radar (BSAR) systems",
            "Generalized ambiguity function (GAF)",
            "Long integration time",
            "Point spread function (PSF) analysis"
        ],
        "venue": "IEEE Geoscience and Remote Sensing Letters",
        "year": 2013,
        "id": "aerfMdvS"
    },
    "ubfwavT4": {
        "id": "ubfwavT4",
        "title": "Acceleration response spectrum for prediction of structural vibration due to individual bouncing",
        "abstract": "Abstract   This study is designed to develop an acceleration response spectrum that can be used in vibration serviceability assessment of civil engineering structures, such as floors and grandstands those are dynamically excited by individual bouncing. The spectrum is derived from numerical simulations and statistical analysis of acceleration responses of a single degree of freedom system with variable natural frequency and damping under a large number of experimentally measured individual bouncing loads. Its mathematical representation is fit for fast yet reliable application in design practice and is comprised of three equations that describe three distinct frequency regions observed in the actual data: the first resonant plateau (2\u20133.5\u00a0Hz), the second resonant plateau (4\u20137\u00a0Hz) and a descension region (7\u201315\u00a0Hz). Finally, this paper verifies the proposed response spectrum approach to predict structural vibration by direct comparison against numerical simulations and experimental results.",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Chen",
                "org": "Department of Structural Engineering/State Key Laboratory for Disaster Reduction in Civil Engineering, Tongji University, Shanghai, PR China"
            },
            {
                "name": "Lei Wang",
                "org": "Department of Structural Engineering, College of Civil Engineering, Tongji University, Shanghai, PR China"
            },
            {
                "name": "Vitomir Racic",
                "org": "Department of Civil and Environmental Engineering, Politecnico di Milano, Italy"
            },
            {
                "name": "Vitomir Racic",
                "org": "Department of Civil and Environmental Engineering, Politecnico di Milano, Italy"
            },
            {
                "name": "Jiayue Lou",
                "org": "Department of Structural Engineering, College of Civil Engineering, Tongji University, Shanghai, PR China"
            }
        ],
        "venue": "Mechanical Systems and Signal Processing",
        "year": 2016
    },
    "mTFn2lPv": {
        "id": "mTFn2lPv",
        "title": "A data-driven wavelet-based approach for generating jumping loads",
        "abstract": "Abstract   This paper suggests an approach to generate human jumping loads using wavelet transform and a database of individual jumping force records. A total of 970 individual jumping force records of various frequencies were first collected by three experiments from 147 test subjects. For each record, every jumping pulse was extracted and decomposed into seven levels by wavelet transform. All the decomposition coefficients were stored in an information database. Probability distributions of jumping cycle period, contact ratio and energy of the jumping pulse were statistically analyzed. Inspired by the theory of DNA recombination, an approach was developed by interchanging the wavelet coefficients between different jumping pulses. To generate a jumping force time history with  N  pulses, wavelet coefficients were first selected randomly from the database at each level. They were then used to reconstruct  N  pulses by the inverse wavelet transform. Jumping cycle periods and contract ratios were then generated randomly based on their probabilistic functions. These parameters were assigned to each of the  N  pulses which were in turn scaled by the amplitude factors       \u03b2    i       to account for energy relationship between successive pulses. The final jumping force time history was obtained by linking all the  N  cycles end to end. This simulation approach can preserve the non-stationary features of the jumping load force in time-frequency domain. Application indicates that this approach can be used to generate jumping force time history due to single people jumping and also can be extended further to stochastic jumping loads due to groups and crowds.",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Chen",
                "org": "Department of Structural Engineering/State Key Laboratory for Disaster Reduction in Civil Engineering, Tongji University, Shanghai, PR China"
            },
            {
                "name": "Guo Li",
                "org": "Department of Structural Engineering, College of Civil Engineering, Tongji University, Shanghai, PR China"
            },
            {
                "name": "Vitomir Racic",
                "org": "Department of Civil and Environmental Engineering, Politecnico di Milano, Italy"
            }
        ],
        "venue": "Mechanical Systems and Signal Processing",
        "year": 2018
    },
    "OpxbhSrg": {
        "id": "OpxbhSrg",
        "title": "Acceleration response spectrum for predicting floor vibration due to occupants jumping",
        "abstract": "Abstract   This paper proposes an acceleration response spectrum to predict floors\u2019 responses due to occupants jumping. Experiments were conducted on individual jumping loads resulting in 506 records. Each record was applied to a single-degree-of-freedom system with various frequencies and damping ratios to obtain a corresponding acceleration response spectrum. Statistical analysis of the results led to a representative spectrum, which is further used to derive an analytical design spectrum curve. The suggested design spectrum covers a structural frequency range of 0.5\u201315\u00a0Hz and consists of three main parts: the first plateau, the second plateau and the descent. Design values for spectrum parameters were determined by fitting each part\u2019s mathematical function to actual data. The proposed spectrum was verified by comparing its predictions with measured responses from an experimental floor model and floors of existing structures induced by both single individuals and crowds jumping.",
        "keywords": "",
        "authors": [
            {
                "name": "Jun Chen",
                "org": "State Key Laboratory of Disaster Reduction in Civil Engineering, Tongji University, Shanghai, PR China"
            },
            {
                "name": "Guo Li",
                "org": "Department of Structural Engineering, College of Civil Engineering, Tongji University, Shanghai, PR China"
            },
            {
                "name": "Vitomir Racic",
                "org": "Department of Civil and Structural Engineering, University of Sheffield, UK"
            },
            {
                "name": "Vitomir Racic",
                "org": "Department of Civil and Structural Engineering, University of Sheffield, UK"
            }
        ],
        "venue": "Engineering Structures",
        "year": 2016
    },
    "wmbCUMP0": {
        "id": "wmbCUMP0",
        "title": "Using inertial measurement units to identify medio-lateral ground reaction forces due to walking and swaying",
        "abstract": "Abstract   Horizontal ground reaction forces (GRFs) due to human walking and swaying have been investigated (respectively) through direct measurements using a treadmill and a set of force plates. These GRFs have also been measured (or estimated) indirectly using acceleration data provided by inertial measurement units (IMUs).  One motivation for this research has been the lack of published data on these two forms of loading that are generated by movements of the human body in the medio-lateral plane perpendicular to the direction of walking or the direction faced during swaying. The other motivation, following from successful developments in applying IMUs to in-situ vertical GRF measurements, has been to identify best practice for estimating medio-lateral GRFs outside the constraints of a laboratory.  Examination of 852 treadmill measurements shows that medio-lateral GRFs at the first sub-harmonic of pacing rate can exceed 10% of body weight. Using a smaller and more recent set of measurements including motion capture, it has been shown that IMUs can be used to reconstruct these GRFs using a linear combination of body accelerations at each of the lower back and sternum positions. There are a number of potential applications for this capability yet to be explored, in particular relating to footbridge performance.  A separate set of measurements using force plates has shown that harmonic components of medio-lateral dynamic load factors due to on the spot swaying can approach 50% of body weight. Such forces provide a capability to excite horizontal vibration modes of large civil structures with frequencies below 2\u202fHz that are problematic for mechanical excitation. As with walking, the ability to use IMUs to estimate medio-lateral swaying GRFs outside laboratory constraints has been demonstrated. As for walking a pair of IMUs is needed, but the best linear combination varies strongly between individuals, according to swaying style. In-situ application of indirect measurement has been successfully demonstrated through a very challenging application of system identification of a multi-storey building, including estimation of modal mass.",
        "keywords": "",
        "authors": [
            {
                "name": "James M. W. Brownjohn",
                "org": "University of Exeter, UK"
            },
            {
                "name": "Jun Chen",
                "org": "Tongji University, China"
            },
            {
                "name": "Mateusz Bocian",
                "org": "University of Leicester, UK"
            },
            {
                "name": "Vitomir Racic",
                "org": "Politecnico di Milano, Italy"
            },
            {
                "name": "Erfan Shahabpoor",
                "org": "University of Bath, UK"
            }
        ],
        "venue": "Journal of Sound and Vibration",
        "year": 2018
    },
    "0wP4NvSA": {
        "id": "0wP4NvSA",
        "title": "Universal response spectrum procedure for predicting walking-induced floor vibration",
        "abstract": "",
        "keywords": [
            "response spectrum"
        ],
        "authors": [
            {
                "name": "j m w brownjohn",
                "org": ""
            },
            {
                "name": "vitomir racic",
                "org": ""
            },
            {
                "name": "jun chen",
                "org": ""
            }
        ],
        "venue": "Mechanical Systems and Signal Processing",
        "year": 2015
    },
    "BxElZgVF": {
        "id": "BxElZgVF",
        "title": "Setting conservation priorities based on ecosystem services - A case study of the Guanzhong-Tianshui Economic Region.",
        "abstract": "Economic development and the increased human demand for natural resources have seriously damaged many ecosystems. Nature reserves are areas with good natural conditions, abundant natural resources and healthy ecosystems that have been established for protection and management. This paper introduces cultural ecosystem services into the selection criteria for priority conservation areas. Both natural and human factors are considered, making it possible to protect both ecological and cultural services in reserves. In this paper, (1) the cultural ecosystem services of the Guanzhong-Tianshui Economic Region were estimated and quantified using questionnaires and the SolVES application; (2) the supplying services (water yield) and regulating services (net primary productivity (NPP), soil conservation) were calculated, and several ecosystem services were valued by models combining human and cultural data; and (3) multiple scenarios were considered, and a priority conservation area with NPP, soil conservation, water yield, aesthetic value and recreation protection efficiencies of 1.315, 2.458, 1.018, 1.414, and 1.079, respectively was selected by comparing the protection efficiencies of the different areas in each scenario to achieve the highest value for the various ecosystem services in the study area. The results provide decision support for the environmental protection of the Guanzhong-Tianshui Economic Region.",
        "keywords": [
            "Cultural services",
            "Ecosystem services",
            "Guanzhong-Tianshui Economic Region",
            "Priority conservation areas",
            "Scenarios"
        ],
        "authors": [
            {
                "name": "Keyu Qin",
                "org": "College of Geography and Tourism, Shaanxi Normal University, Xi'an 710062, Shaanxi, China; Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, Shangdong, China; University of the Chinese Academy of Sciences, Beijing 100049, China."
            },
            {
                "name": "Jing Li",
                "org": "College of Geography and Tourism, Shaanxi Normal University, Xi'an 710062, Shaanxi, China. Electronic address: lijing@snnu.edu.cn."
            },
            {
                "name": "Jingya Liu",
                "org": "College of Geography and Tourism, Shaanxi Normal University, Xi'an 710062, Shaanxi, China; Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China."
            },
            {
                "name": "Liwen Yan",
                "org": "Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, Shangdong, China; University of the Chinese Academy of Sciences, Beijing 100049, China."
            },
            {
                "name": "Haijun Huang",
                "org": "Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, Shangdong, China; University of the Chinese Academy of Sciences, Beijing 100049, China."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2019
    },
    "EgFIVuLZ": {
        "id": "EgFIVuLZ",
        "title": "Changes in land-uses and ecosystem services under multi-scenarios simulation.",
        "abstract": "Social economy of China has been rapidly developing for more than 30years with efficient reforms and policies being issued. Societal developments have resulted in a greater use of many natural resources to the extent that the ecosystem can no longer self-regulate, thus severely damaging the balance of the ecosystem itself. This in turn has led to a deterioration in people's living environments. Our research is based on a combination of climate scenarios presented in the fifth report of the Intergovernmental Panel on Climate Change (IPCC) and policy scenarios, including the one-child policy and carbon tax policy. We adopted Land Change Modeler of IDRISI software to simulate and analyze land-use change under 16 future scenarios in 2050. Carbon sequestration, soil conservation and water yields were quantified, based on those land-use maps and different ecosystem models. We also analyzed trade-offs and synergy among each ecosystem service and discussed why those interactions happened. The results show that: (1) Global climate change has a strong influence on future changes in land-use. (2) Carbon sequestration, water yield and soil conservation have a mutual relationship in the Guanzhong-Tianshui economic region. (3) Climate change and implementation of policy have a conspicuous impact on the changes in ecosystem services in the Guanzhong-Tianshui economic region. This paper can be used as a reference for further related research, and provide a reliable basis for achieving the sustainable development of the ecosystem.",
        "keywords": [
            "Ecosystem services",
            "Guanzhong-Tianshui economic region",
            "Land change modeler",
            "Land-use",
            "Scenario"
        ],
        "authors": [
            {
                "name": "Jingya Liu",
                "org": "College of Tourism and Environment, Shaanxi Normal University, 710062 Xi'an, Shaanxi, China."
            },
            {
                "name": "Jing Li",
                "org": "College of Tourism and Environment, Shaanxi Normal University, 710062 Xi'an, Shaanxi, China. Electronic address: lijing@snnu.edu.cn."
            },
            {
                "name": "Keyu Qin",
                "org": "Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, 266000 Qingdao, Shandong, China."
            },
            {
                "name": "Zixiang Zhou",
                "org": "College of Geomatics, Xi'an University of Science and Technology, 710062 Xi'an, Shaanxi, China."
            },
            {
                "name": "Xiaonan Yang",
                "org": "College of Tourism and Environment, Shaanxi Normal University, 710062 Xi'an, Shaanxi, China."
            },
            {
                "name": "Ting Li",
                "org": "College of Tourism and Environment, Shaanxi Normal University, 710062 Xi'an, Shaanxi, China."
            }
        ],
        "venue": "The Science of the total environment",
        "year": 2017
    },
    "n8AsI00O": {
        "id": "n8AsI00O",
        "title": "Taking climate, land use, and social economy into estimation of carbon budget in the Guanzhong-Tianshui Economic Region of China.",
        "abstract": "Carbon sequestration is an indispensable ecosystem service provided by soil and vegetation, so mapping and valuing the carbon budget by considering both ecological and social factors is an important trend in evaluating ecosystem services. In this work, we established multiple scenarios to evaluate the impacts of land use change, population growth, carbon emission per capita, and carbon markets on carbon budget. We quantified carbon sinks (aboveground and belowground) under different scenarios, using the Carnegie-Ames-Stanford Approach (CASA) model and an improved carbon cycle process model, and studied carbon sources caused by human activities by analyzing the spatial distribution of human population and carbon emission per capita. We also assessed the net present value (NPV) for carbon budgets under different carbon price and discount rate scenarios using NPV model. Our results indicate that the carbon budget of Guanzhong-Tianshui Economic Region is surplus: Carbon sinks range from 1.50\u00a0\u00d7\u00a010 to 1.54\u00a0\u00d7\u00a010\u00a0t, while carbon sources caused by human activities range from 2.76\u00a0\u00d7\u00a010 to 7.60\u00a0\u00d7\u00a010\u00a0t. And the NPV for carbon deficits range from 3.20\u00a0\u00d7\u00a010 RMB to 1.52\u00a0\u00d7\u00a010 RMB. From the perspective of ecological management, deforestation, urban sprawl, population growth, and excessive carbon consumption are considered as the main challenges in balancing carbon sources and sinks. Levying carbon tax would be a considerable option when decision maker develops carbon emission reduction policies. Our results provide a scientific and credible reference for harmonious and sustainable development in the Guanzhong-Tianshui Economic Region of China.",
        "keywords": [
            "Carbon budget",
            "Scenario",
            "The Guanzhong-Tianshui Economic Region"
        ],
        "authors": [
            {
                "name": "Ting Li",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an, Shaanxi, 710000, People's Republic of China."
            },
            {
                "name": "Jing Li",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an, Shaanxi, 710000, People's Republic of China. lijing@snnu.edu.cn."
            },
            {
                "name": "Zixiang Zhou",
                "org": "College of Geomatics, Xi'an University of Science and Technology, Xi'an, 710054, People's Republic of China."
            },
            {
                "name": "Yanze Wang",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an, Shaanxi, 710000, People's Republic of China."
            },
            {
                "name": "Xiaonan Yang",
                "org": "Institute of Soil and Water Conservation, Northwest A & F University, Yangling, 712100, People's Republic of China."
            },
            {
                "name": "Keyu Qin",
                "org": "Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong, 266071, People's Republic of China."
            },
            {
                "name": "Jingya Liu",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an, Shaanxi, 710000, People's Republic of China."
            }
        ],
        "venue": "Environmental science and pollution research international",
        "year": 2017
    },
    "Ur8gGlSc": {
        "id": "Ur8gGlSc",
        "title": "Trade-Off and Synergy among Ecosystem Services in the Guanzhong-Tianshui Economic Region of China",
        "abstract": "",
        "keywords": [
            "trade off",
            "synergy",
            "ecosystem service"
        ],
        "authors": [
            {
                "name": "keyu qin",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "xiaonan yang",
                "org": ""
            }
        ],
        "venue": "International Journal of Environmental Research and Public Health",
        "year": 2015
    },
    "KonQM4mM": {
        "id": "KonQM4mM",
        "title": "Carbon sequestration service flow in the Guanzhong-Tianshui economic region of China: How it flows, what drives it, and where could be optimized?",
        "abstract": "Abstract   The temporal and spatial delivery of ecosystem services is inevitable link between ecosystem and human. But few studies to date have visualized ecosystem services supply and demand from ecosystem process viewpoint. In this study, we simulate the supply-demand spatial matching of carbon sequestration service, visualize the magnitude- and direction-component of carbon sequestration service flows, and select suitable areas for low-carbon target-oriented optimal allocation in the Guanzhong-Tianshui Economic Region (GTER) of China. Our results indicate that carbon sequestration service supply in GTER can meet the regional demand; carbon sequestration centers ( R i  \u202fu003e\u202f0.04) are Tianshui, Binxian, Pucheng, Fengxiang and the urban agglomeration on Guanzhong plain which includes Xi\u2019an, Xianyang, and Baoji; Qinling Mountains and Beishan Mountains provide carbon sequestration service for the 5 typical carbon sequestration sub-regions of GTER through carbon sequestration service flows with diverse magnitudes and directions; Ecological factors of NPP, DEM and PET are key dynamic forces for carbon sequestration service supply; Priority areas for low-carbon target-oriented optimal allocation are situated in the west of Qinling Mountains.",
        "keywords": "",
        "authors": [
            {
                "name": "Ting Li",
                "org": "School of Geography and Tourism, Shaanxi Normal University, PR China"
            },
            {
                "name": "Jing Li",
                "org": "School of Geography and Tourism, Shaanxi Normal University, PR China"
            },
            {
                "name": "Yanze Wang",
                "org": "School of Geography and Tourism, Shaanxi Normal University, PR China"
            }
        ],
        "venue": "Ecological Indicators",
        "year": 2019
    },
    "0c4JWXGH": {
        "id": "0c4JWXGH",
        "title": "Trade-offs between carbon sequestration, soil retention and water yield in the Guanzhong-Tianshui Economic Region of China",
        "abstract": "Natural ecosystems provide human society with very important products and services. With the rapid increase in population and the over-exploitation of natural resources, humans are continually enhancing the production of some services at the expense of others. This paper estimates changes in ecosystem services, and the relationship between these services in the Guanzhong-Tianshui Economic Region of China. These ecosystem changes are of great significance to the sustainable development of this economic region. The concept of production possibility frontier (PPF) is applied to evaluate the trade-offs and synergy between carbon sequestration, water yield and soil retention. Three land use strategy scenarios\u2013planning, exploitation and protection\u2013are applied to evaluate potential changes in ecosystem services. This study reveals noticeable trade-offs between carbon sequestration, soil retention and water yield, with synergy between carbon sequestration and soil retention. There are synergies between carbon sequestration, water yield and soil retention in the three scenarios. The protection scenario is the most favourable land use strategy for regulating ecosystem service capacity. This scenario results in the highest carbon sequestration, water yield and soil retention. The results could have implications for natural capital and ecosystem services planning, management and land use decision-making.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaonan Yang",
                "org": "Northwest A&F University"
            },
            {
                "name": "Zixiang Zhou",
                "org": "Northwest A&F University"
            },
            {
                "name": "Jing Li",
                "org": "Shaanxi Normal University"
            },
            {
                "name": "Xin Fu",
                "org": "Northwest University"
            },
            {
                "name": "Xingmin Mu",
                "org": "Northwest A&F University"
            },
            {
                "name": "Ting Li",
                "org": "Shaanxi Normal University"
            }
        ],
        "venue": "Journal of Geographical Sciences",
        "year": 2016
    },
    "FsD3QDea": {
        "id": "FsD3QDea",
        "title": "Ecosystem Services Insights into Water Resources Management in China: A Case of Xi'an City.",
        "abstract": "Global climate and environmental changes are endangering global water resources; and several approaches have been tested to manage and reduce the pressure on these decreasing resources. This study uses the case study of Xi'an City in China to test reasonable and effective methods to address water resource shortages. The study generated a framework combining ecosystem services and water resource management. Seven ecosystem indicators were classified as supply services, regulating services, or cultural services. Index values for each indicator were calculated, and based on questionnaire results, each index's weight was calculated. Using the Likert method, we calculated ecosystem service supplies in every region of the city. We found that the ecosystem's service capability is closely related to water resources, providing a method for managing water resources. Using Xi'an City as an example, we apply the ecosystem services concept to water resources management, providing a method for decision makers.",
        "keywords": [
            "Xi\u2019an",
            "ecosystem service",
            "ecosystem service indicators",
            "survey",
            "water resources management"
        ],
        "authors": [
            {
                "name": "Jingya Liu",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an 710062, Shaanxi, China. liujingya0709@163.com."
            },
            {
                "name": "Jing Li",
                "org": "Key Laboratory of Disaster Monitoring and Mechanism Simulation, Baoji University of Arts and Sciences, Baoji 721000, Shaanxi, China. lijing@snnu.edu.cn."
            },
            {
                "name": "Ziyi Gao",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an 710062, Shaanxi, China. m18535840577_1@163.com."
            },
            {
                "name": "Min Yang",
                "org": "College of Territorial Resources and Tourism, Anhui Normal University, Wuhu 241000, Anhui, China. ahnuyangmin@163.com."
            },
            {
                "name": "Keyu Qin",
                "org": "Key Laboratory of Marine Geology and Environment, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, Shangdong, China. qdqky924@126.com."
            },
            {
                "name": "Xiaonan Yang",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi'an 710062, Shaanxi, China. yangxiaonan@snnu.edu.cn."
            }
        ],
        "venue": "International journal of environmental research and public health",
        "year": 2016
    },
    "1ljlZjeA": {
        "id": "1ljlZjeA",
        "title": "Trade-offs between carbon, water, soil and food in Guanzhong-Tianshui economic region from remotely sensed data.",
        "abstract": "Abstract   It is important to ensure the efficient supply of land ecosystem services when the competition for land is increasing. In this paper we simulated the ecosystem services function under two scenarios, including carbon sequestration, agricultural production, water and soil conservation, and analyzed the tradeoffs among these ecosystem services in Guanzhong-Tianshui region from 2000 to 2050. Then the productive efficiency of ecosystem services was assessed under two scenarios and compared their production possibility frontiers (PPFs). Through the simulation analysis of their optimum allocation, we also provide the scientific evidence to the development of ecosystem. The natural rules were revealed that if these trade-offs emphasize the potential to sequester carbon in the landscape, along with very little loss of agricultural production, much more water is used. It could be identified to adhere to combine the exploitation and utilization, remediation and protection for land to promote the effective circulation of land eco-system, and meet the society\u2019s preferences for land ecosystem service function by adjusting the use of multiple eco-services.",
        "keywords": "",
        "authors": [
            {
                "name": "Z. X. Zhou",
                "org": "College of Geomatics, Xi'an University of Science and Technology, Xi\u2019an, Shaanxi,, PR China"
            },
            {
                "name": "Jing Li",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi\u2019an, Shaanxi, PR China"
            },
            {
                "name": "Z. Z. Guo",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi\u2019an, Shaanxi, PR China"
            },
            {
                "name": "Ting Li",
                "org": "College of Tourism and Environment, Shaanxi Normal University, Xi\u2019an, Shaanxi, PR China"
            }
        ],
        "venue": "Int. J. Applied Earth Observation and Geoinformation",
        "year": 2017
    },
    "Hk1fB1jy": {
        "id": "Hk1fB1jy",
        "title": "Ecosystem services and their values: a case study in the Qinba mountains of China",
        "abstract": "Terrestrial ecosystem services can provide both direct and indirect economic benefits. In this case study, we estimated the annual economic value of some ecosystem services provided by terrestrial ecosystems in the Qinba mountains of Shaanxi Province of China, using both simulation models and a geographic information system that helps to analyze the effect of ecological factors on ecosystem functions. With respect to differences in vegetation types and their coverage, by combining the latest research, and using theory and methods for the value of terrestrial ecosystem services, we not only calculated goods produced by different types of vegetation but also estimated the value of various terrestrial ecosystem services. We also set up a database and an eco-account of a terrestrial ecosystem. The ecosystem services assessed relate to the following aspects: the vegetations primary productivity, soil and fertility conservation, water conservation, carbon fixation and oxygen supply. The total economic value of terrestrial ecosystem services in the Qinba mountains was estimated to be 968.33 billion renminbi per year, and represents a part of the actual ecosystem services. In addition, we analyzed the spatial distribution of the vegetation based on the economic values of the terrestrial ecosystem services. Our findings can contribute to the conservation of these terrestrial ecosystems and the effective use of these ecosystem services.",
        "keywords": [
            "terrestrial ecosystem services \u00e6 ecological economic value \u00e6 qinba mountains \u00e6 green eco-account",
            "simulation model",
            "geographic information system",
            "economic value",
            "primary production",
            "terrestrial ecosystems",
            "water conservation",
            "ecosystem service",
            "ecological economics"
        ],
        "authors": [
            {
                "name": "Jing Li",
                "org": "Shaanxi Normal University College of Tourism and Environment 710062 Xi\u2019an People\u2019s Republic of China 710062 Xi\u2019an People\u2019s Republic of China"
            },
            {
                "name": "Zhiyuan Ren",
                "org": "Shaanxi Normal University College of Tourism and Environment 710062 Xi\u2019an People\u2019s Republic of China 710062 Xi\u2019an People\u2019s Republic of China"
            },
            {
                "name": "Zixiang Zhou",
                "org": "Shaanxi Normal University College of Tourism and Environment 710062 Xi\u2019an People\u2019s Republic of China 710062 Xi\u2019an People\u2019s Republic of China"
            }
        ],
        "venue": "Ecological Research",
        "year": 2006
    },
    "vXnXYa5C": {
        "id": "vXnXYa5C",
        "title": "Intraoperative monitoring of facial aberrant responses during microvascular decompression for hemifacial spasm",
        "authors": [
            {
                "name": "WANG Shi-jie",
                "org": ". Department of Neurosurgery, Tsinghua University Yuquan Hospital , Bejing , China"
            },
            {
                "name": "CHEN Guo-qiang",
                "org": ". Department of Neurosurgery, Tsinghua University Yuquan Hospital , Bejing , China"
            },
            {
                "name": "ZUO Huan-cong",
                "org": ". Department of Neurosurgery, Tsinghua University Yuquan Hospital , Bejing , China"
            }
        ],
        "venue": "chinese journal of neurosurgery",
        "keywords": [
            "Hemifacial spasm",
            "Microvascular decompression",
            "Aberrant response",
            "Intraoperative monitoring"
        ],
        "year": 2006
    },
    "R6wfdYBM": {
        "id": "R6wfdYBM",
        "title": "Stereotactic neurosurgery for intractable central pain",
        "authors": [
            {
                "name": "Wang Lin",
                "org": ",et al.Department of Neurosurgery,The Affiliated Yuquan Hospital of Tsinghua University,Beijing,."
            },
            {
                "name": "Chen Guoqiang",
                "org": ",et al.Department of Neurosurgery,The Affiliated Yuquan Hospital of Tsinghua University,Beijing,."
            },
            {
                "name": "Tian Hong",
                "org": ",et al.Department of Neurosurgery,The Affiliated Yuquan Hospital of Tsinghua University,Beijing,."
            }
        ],
        "venue": "chinese journal of stereotactic and functional neurosurgery",
        "keywords": [
            "Nucleus accumbens",
            "Central pain",
            "Cingulate gyrus",
            "Stereotactic neurosurgery"
        ],
        "year": 2009
    },
    "XAf2xUIv": {
        "id": "XAf2xUIv",
        "title": "Causes of ineffectiveness of microvascular decompression for hemifacial spasm]",
        "authors": [
            {
                "name": "Yuan Yue",
                "org": "Department of Neurosurgery, China-Japan Friendship Hospital, Ministry of Health, Beijing 100029, China."
            },
            {
                "name": "Zhang Li"
            },
            {
                "name": "Zhang Si-xun"
            },
            {
                "name": "Yu Yan-bing"
            },
            {
                "name": "Chen Guo-qiang"
            },
            {
                "name": "Zhao Kui-ming"
            },
            {
                "name": "Guo Jing"
            },
            {
                "name": "Zuo Huan-cong"
            }
        ],
        "venue": "zhonghua wai ke za zhi [chinese journal of surgery]",
        "keywords": [],
        "year": 2003
    },
    "F1zm1TMP": {
        "id": "F1zm1TMP",
        "title": "Endoscopic procedures for patients with shunt malfunction",
        "authors": [
            {
                "name": "XIAO Qing",
                "org": "Department of Neurosurgery, the Affiliated Yuquan Hospital of Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "CHEN Guo-qiang",
                "org": "Department of Neurosurgery, the Affiliated Yuquan Hospital of Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "ZHENG Jia-ping",
                "org": "Department of Neurosurgery, the Affiliated Yuquan Hospital of Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "LIANG Hui",
                "org": "Department of Neurosurgery, the Affiliated Yuquan Hospital of Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "ZUO Huan-cong",
                "org": "Department of Neurosurgery, the Affiliated Yuquan Hospital of Tsinghua University, Beijing , P.R.China"
            }
        ],
        "venue": "china journal of endoscopy",
        "keywords": [
            "endoscopic procedure",
            "shunt malfunction",
            "hydrocephalus"
        ],
        "year": 2009
    },
    "Jez1rOck": {
        "id": "Jez1rOck",
        "title": "Arachnoid cysts of the ipsilateral cerebellopontine angle and hemifacial spasms",
        "authors": [
            {
                "name": "Wang Yan",
                "org": ",et al.Department of Neurosurgery,The Affiliated Yuquan Hospital of Qinghua University,Beijing,"
            },
            {
                "name": "Chen Guoqiang",
                "org": ",et al.Department of Neurosurgery,The Affiliated Yuquan Hospital of Qinghua University,Beijing,"
            },
            {
                "name": "Wang Xiaosong",
                "org": ",et al.Department of Neurosurgery,The Affiliated Yuquan Hospital of Qinghua University,Beijing,"
            }
        ],
        "venue": "chinese journal of stereotactic and functional neurosurgery",
        "keywords": [
            "Hemifacial spasms",
            "Microvascular decompression operation",
            "Arachnoid cysts"
        ],
        "year": 2008
    },
    "ujuimdjH": {
        "id": "ujuimdjH",
        "title": "Psychological Investigation and Analysis of The Patiente with Hemifacial Spasm Treated by Microvascular Decompression",
        "authors": [
            {
                "name": "GUO Yu-peng",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "WANG Xiao-song",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "CHEN Guo-qiang",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "ZHU Yan",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "ZUO Huan-cong",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "TANG Jin-tian",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "XIAO Qing",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "ZHENG Jia-ping",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            },
            {
                "name": "LIANG Hui",
                "org": "Department of Neurosurgery,Y u-quan Hospital,Tsinghua university,Beijing ,China"
            }
        ],
        "venue": "guide of china medicine",
        "keywords": [
            "Selfrating Anxiety Scale(SAS)",
            "Selfrating Depression Scale(SDS)",
            "Hemifacial Spasm"
        ],
        "year": 2011
    },
    "X1Qo1wP9": {
        "id": "X1Qo1wP9",
        "title": "Endoscopic surgery in children for intracranial cysts of the posterior fossa combined with obstructive hydrocephalus",
        "authors": [
            {
                "name": "CHEN Guo-qiang",
                "org": "Department of Neurosurgery, Yu-quan Hospital, Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "XIAO Qing",
                "org": "Department of Neurosurgery, Yu-quan Hospital, Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "ZHENG Jia-ping",
                "org": "Department of Neurosurgery, Yu-quan Hospital, Tsinghua University, Beijing , P.R.China"
            },
            {
                "name": "ZUO Huan-cong",
                "org": "Department of Neurosurgery, Yu-quan Hospital, Tsinghua University, Beijing , P.R.China"
            }
        ],
        "venue": "china journal of endoscopy",
        "keywords": [
            "obstructive hydrocephalus",
            "intracranial cysts of the posterior fossa",
            "children",
            "endoscopic surgery"
        ],
        "year": 2008
    },
    "a1stP7br": {
        "id": "a1stP7br",
        "title": "Microvascular decompression to treat hemifaciai spasm:a review of 4260 operations performed during the past 20 years",
        "authors": [
            {
                "name": "ZUO Huan-cong",
                "org": "* Department of Neurosurgery Yuquan Hospital Tsinghua University, Beifing , China"
            },
            {
                "name": "CHEN Guo-qiang",
                "org": "* Department of Neurosurgery Yuquan Hospital Tsinghua University, Beifing , China"
            },
            {
                "name": "YUAN Yue",
                "org": "* Department of Neurosurgery Yuquan Hospital Tsinghua University, Beifing , China"
            }
        ],
        "venue": "chinese journal of neurosurgery",
        "keywords": [
            "Hemifacial spasm",
            "Microvascular decompression"
        ],
        "year": 2006
    },
    "zPsHXS99": {
        "id": "zPsHXS99",
        "title": "Hearing impairment after microvascular decompression for hemifacial spasm",
        "authors": [
            {
                "name": "HUANG Ligang",
                "org": ".1)Department of Surgical Saff Room,Weifang Medical College,Weifang ,China"
            },
            {
                "name": "CHEN Guoqiang",
                "org": "Department of Neurosurgery,Yuquan Hospital of Tsinghua University"
            },
            {
                "name": "ZHANG He",
                "org": "Department of Neurosurgery,the Affiliated Hospital of Weifang Medical College"
            }
        ],
        "venue": "clinical medicine",
        "keywords": [
            "Hemifacial spasm",
            "Microvascular decompression",
            "Hearing impairment"
        ],
        "year": 2010
    },
    "MJgTp1bo": {
        "id": "MJgTp1bo",
        "title": "Microsurgery of the Recurrent Trigeminal Neuralgia after Gasserian Ganglion Radiofrequency Therapy",
        "authors": [
            {
                "name": "WANG Yan",
                "org": " Neurosurgery Department, Yuquan Hospital, Tsinghua University, Beijing , China"
            },
            {
                "name": "WANG Zhenhai",
                "org": " The First Neurosurgery Department, Xingtai Renmin Hospital, Xingtai , Hebei Province, China"
            },
            {
                "name": "WANG Xiaosong",
                "org": " Neurosurgery Department, Yuquan Hospital, Tsinghua University, Beijing , China"
            },
            {
                "name": "SUN Jidong",
                "org": " Neurosurgery Department, Yuquan Hospital, Tsinghua University, Beijing , China"
            },
            {
                "name": "CHEN Guoqiang",
                "org": " Neurosurgery Department, Yuquan Hospital, Tsinghua University, Beijing , China"
            },
            {
                "name": "ZUO Huancong",
                "org": " Neurosurgery Department, Yuquan Hospital, Tsinghua University, Beijing , China"
            }
        ],
        "venue": "science & technology review",
        "keywords": [
            "microvascular decompression operation",
            "trigeminal neuralgia",
            "gasserian ganglion radiofrequency therapy"
        ],
        "year": 2009
    },
    "FNIhaWIr": {
        "id": "FNIhaWIr",
        "title": "Spontaneous dissecting aneurysm of the middle cerebral artery: a case report and review of the literature",
        "authors": [
            {
                "name": "CHEN Guo-qiang",
                "org": ", et al. Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing , China"
            },
            {
                "name": "HAN Hong-yan",
                "org": ", et al. Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing , China"
            },
            {
                "name": "WANG Xiao-song",
                "org": ", et al. Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing , China"
            }
        ],
        "venue": "chinese journal of neurosurgery",
        "keywords": [
            "Middle cerebral artery",
            "Surgery",
            "Dissecting aneurysm"
        ],
        "year": 2006
    },
    "zGG4xEUM": {
        "id": "zGG4xEUM",
        "title": "Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia on chronic phase in gerbils",
        "authors": [
            {
                "name": "Jin Yongjian",
                "org": ".Department of Neurosurgery,Yuquan Hospital,Tsinghua University,Beijing,,China"
            },
            {
                "name": "Wang Lin",
                "org": ".Department of Neurosurgery,Yuquan Hospital,Tsinghua University,Beijing,,China"
            },
            {
                "name": "Chen Guoqiang",
                "org": ".Department of Neurosurgery,Yuquan Hospital,Tsinghua University,Beijing,,China"
            }
        ],
        "venue": "chinese journal of stereotactic and functional neurosurgery",
        "keywords": [
            "Gerbil",
            "Forebrain ischemia",
            "Argatroban",
            "Neuroprotection",
            "Edaravone"
        ],
        "year": 2010
    },
    "sVvOxycz": {
        "id": "sVvOxycz",
        "title": "Clinicopathologic features of dysembryoplastic neuroepithelial tumor",
        "authors": [
            {
                "name": "SUN Ji-dong",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "WANG Dan-dan",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "ZHENG Yong-gang",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "ZHENG Zhong",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "HU Jing-xia",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "HAN Hong-yan",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "WANG Shi-lun",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            },
            {
                "name": "CHEN Guo-qiang",
                "org": "~*. * Department of Neurosurgery, Tsinghua University Yuquan Hospital, Beijing , China"
            }
        ],
        "venue": "chinese journal of neuroimmunology and neurology",
        "keywords": [
            "epilepsy",
            "immunohistochemistry",
            "pathology",
            "tumor"
        ],
        "year": 2010
    },
    "g3EPruXD": {
        "authors": [
            {
                "name": "Gui Fang Wang",
                "org": "College of Resources and Metallurgy"
            },
            {
                "name": "Shao Jian Ma",
                "org": "College of Resources and Metallurgy"
            },
            {
                "name": "Shuai Zhang",
                "org": "Sinosteel Mining Company Limited"
            },
            {
                "name": "Xian Jun Lu",
                "org": "College of Chemical and Environmental Engineering"
            },
            {
                "name": "Wei Mo",
                "org": "College of Resources and Metallurgy"
            },
            {
                "name": "Jin Lin Yang",
                "org": "College of Resources and Metallurgy"
            }
        ],
        "title": "Study on porous structure and surface characteristics of Al-pillared montmorillonite",
        "abstract": "Al-pillared montmorillonite (Al-PILM) prepared with Keggin ions was studied by means of XRD, SEM-EDS and N",
        "keywords": [
            "Al-pillared montmorillonite",
            "Porosity",
            "Surface characteristic"
        ],
        "venue": "Advanced Materials Research",
        "year": 2011,
        "id": "g3EPruXD"
    },
    "IsU9dHSe": {
        "authors": [
            {
                "name": "Guifang Wang",
                "org": ""
            },
            {
                "name": "Xianjun Lu",
                "org": ""
            },
            {
                "name": "Shuai Zhang",
                "org": ""
            },
            {
                "name": "Shaojian Ma",
                "org": ""
            },
            {
                "name": "Jun Qiu",
                "org": ""
            },
            {
                "name": "Jinlin Yang",
                "org": ""
            }
        ],
        "title": "Study on microstructure variation laws of Al-pillared montmorillonite",
        "abstract": "Al",
        "keywords": [
            "Al-pillared montmorillonite",
            "Microstructure",
            "Porosity",
            "Specific surface area"
        ],
        "venue": "Advanced Materials Research",
        "year": 2011,
        "id": "IsU9dHSe"
    },
    "e8emT4YD": {
        "id": "e8emT4YD",
        "title": "Effects of temperature and salinity on embryonic development of barfin flounder Verasper moseri",
        "authors": [
            {
                "name": "WANG Yan-yan",
                "org": " Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao ; Fisheries College , Ocean University of China, Qingdao "
            },
            {
                "name": "LIU Xue-zhou",
                "org": " Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "LIU Xin-fu",
                "org": " Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "CHEN Chao",
                "org": " Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "XU Yong-jiang",
                "org": " Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "ZHAI Jie-ming",
                "org": " Mingbo Fisheries Corporation,ltd.Laizhou "
            }
        ],
        "venue": "marine fisheries research",
        "keywords": [
            "Verasper moseri Embryonic development Temperature Salinity"
        ],
        "year": 2008
    },
    "OixTLizO": {
        "id": "OixTLizO",
        "title": "Histological studies on development of digestive system in larval and juvenile dark pomfret(Pampus cinereus)",
        "abstract": "Morphological and histological studies have been made on the digestive system of dark pomfret(Pampus cinereus) from the first day to the 35th day after being hatched.In newly hatched larva,yolk sac was large and the digestive tract was a straight diverticulum.The histological differentiation occurred first in mid-gut of DAH 2 larva,and striated borders also appeared on the free surface of epithelial cells of the mid-gut.On DAH 3,the stomach of larva inflated,yolk disappeared and intestine was differentiated into small intestine and rectum.The esophageal sac first appeared on DAH 4.The original structure of pyloric caeca could be observed,whereas fat ball disappeared,and the transition from endogenous nutrition to exogenous one was mostly finished on DAH 5.Larva began to ingest exogenous food on DAH 6.On the 14th day,the liver of juvenile fish was separated into two lobes.The volume of the liver and pancreas increased,while the stomach was twisted into \"U\"-like shape,and the number of the rami of the pyloric caeca increased to dozens.Intestine of the 22-day juvenile fish had more delete flexion,similar with that of young fish.The mediastinum and horny spine were observed in the esophageal sac of the 28-day juvenile.The powerful gastric gland and esophageal sac appeared in 35-day juvenile fish,suggesting that the structure and function of the digestive system of dark pomfret have been developed.",
        "keywords": [
            "morphology",
            "digestive system",
            "larva and juvenile",
            "dark pomfret(Pampus cinereus)",
            "histology"
        ],
        "authors": [
            {
                "name": "SHI Zhao-hong",
                "org": "Key Laboratory of Marine and Estuary Fisheries Resource and Ecology,Ministry of Agriculture of China,East China Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Shanghai ,China"
            },
            {
                "name": "GAO Lu-jiao",
                "org": "Key Laboratory of Marine and Estuary Fisheries Resource and Ecology,Ministry of Agriculture of China,East China Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Qingdao ,China"
            },
            {
                "name": "PENG Shi-ming",
                "org": "Key Laboratory of Marine and Estuary Fisheries Resource and Ecology,Ministry of Agriculture of China,East China Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Shanghai ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "Key Laboratory of Marine and Estuary Fisheries Resource and Ecology,Ministry of Agriculture of China,East China Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Shanghai ,China"
            }
        ],
        "venue": "Marine Fisheries",
        "year": 2009
    },
    "UIqDFirL": {
        "id": "UIqDFirL",
        "title": "Biological Characteristics and Progress of Artificial Breeding Technique for Kelp Bass,Epinephelus moara",
        "authors": [
            {
                "name": "SONG Zhen-xin",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ;College of Fisheries and Life Science,Shanghai Ocean University,Shanghai "
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "ZHAI Jie-ming",
                "org": "Mingbo Fisheries Limited Corporation,Laizhou "
            },
            {
                "name": "MA Wen-hui",
                "org": "Mingbo Fisheries Limited Corporation,Laizhou "
            },
            {
                "name": "PANG Zun-fang",
                "org": "Mingbo Fisheries Limited Corporation,Laizhou "
            }
        ],
        "venue": "fishery information & strategy",
        "keywords": [
            "Kelp bass",
            "Artificial breeding",
            "Biological characteristics"
        ],
        "year": 2012
    },
    "bGfehwQ5": {
        "id": "bGfehwQ5",
        "title": "Study on artificial breeding of Amphiprion ocellaris",
        "authors": [
            {
                "name": "WANG Bin",
                "org": "Qingdao Sea World,"
            },
            {
                "name": "WANG Shi-li",
                "org": "Qingdao Sea World,"
            },
            {
                "name": "YANG Ai-guo",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "LI Di",
                "org": "Qingdao Sea World,"
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Amphiprion ocellaris Embryonic development Breeding"
        ],
        "year": 2010
    },
    "cbWABMbX": {
        "id": "cbWABMbX",
        "title": "The effects of starvation and re-feeding on fatty acid and amino acid composition in juvenile of Epinephelus malabaricus Bloch & Schneider",
        "authors": [
            {
                "name": "CHEN Bo",
                "org": "Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan Fisheries Research Institute of Zhejiang Province,Zhoushan ,China"
            },
            {
                "name": "LIU Min-hai",
                "org": "Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan Fisheries Research Institute of Zhejiang Province,Zhoushan ,China"
            },
            {
                "name": "SHI Zhao-hong",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fisheries Sciences,Qingdao ,China"
            },
            {
                "name": "LUO Hai-zhong",
                "org": "Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan Fisheries Research Institute of Zhejiang Province,Zhoushan ,China"
            },
            {
                "name": "PENG Zhi-lan",
                "org": "Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan Fisheries Research Institute of Zhejiang Province,Zhoushan ,China"
            },
            {
                "name": "FU Rong-bing",
                "org": "Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan Fisheries Research Institute of Zhejiang Province,Zhoushan ,China"
            }
        ],
        "venue": "journal of shanghai fisheries university",
        "keywords": [
            "amino acid",
            "compensatory growth",
            "fatty acid",
            "starvation",
            "Epinephelus malabaricus Bloch & Schneider"
        ],
        "year": 2008
    },
    "Mg8RAhWU": {
        "id": "Mg8RAhWU",
        "title": "Fish hybridization and its application in grouper",
        "authors": [
            {
                "name": "LI Yan-lu",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "ZHAI Jie-ming",
                "org": "Laizhou Mingbo Fisheries Limited Company,Yantai ,China"
            },
            {
                "name": "LI Bo",
                "org": "Laizhou Mingbo Fisheries Limited Company,Yantai ,China"
            },
            {
                "name": "WANG Qing-yin",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            }
        ],
        "venue": "marine fisheries",
        "keywords": [
            "genetic analysis",
            "crossbreeding",
            "grouper"
        ],
        "year": 2012
    },
    "j3OqL3CC": {
        "id": "j3OqL3CC",
        "title": "Effects of pure oxygen aeration on the growth of cultured turbot (Scophthatmus maximus) and water quality indices",
        "authors": [
            {
                "name": "GAO Xiao-tian",
                "org": "Ocean University of China, Qingdao "
            },
            {
                "name": "MA Ai-jun",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qindao "
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qindao "
            },
            {
                "name": "WANG Yin-geng",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qindao "
            },
            {
                "name": "WANG Xin-an",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qindao "
            },
            {
                "name": "YANG Zhi",
                "org": "Yantai Tianyuan Aquatic Limited Corporation, Yantai "
            },
            {
                "name": "QU Jiang-bo",
                "org": "Yantai Tianyuan Aquatic Limited Corporation, Yantai "
            }
        ],
        "venue": "marine fisheries research",
        "keywords": [
            "Pure oxygen aeration Turbot (Scophthatmus maximus) Growth Water quality indices Effect"
        ],
        "year": 2007
    },
    "JPgEno07": {
        "id": "JPgEno07",
        "title": "Research Progress on Reproduction Biology and Artificial Propagation Technique of Epinephelus septemfasciatus",
        "authors": [
            {
                "name": "WU Lei-ming",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China;Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China;Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "DI JIE-ming",
                "org": " Laizhou Mingbo Fishery Co. Ltd. Yantai,Shandong ,China"
            },
            {
                "name": "LI Bo",
                "org": " Laizhou Mingbo Fishery Co. Ltd. Yantai,Shandong ,China"
            },
            {
                "name": "PANG Zun-fang",
                "org": " Laizhou Mingbo Fishery Co. Ltd. Yantai,Shandong ,China"
            },
            {
                "name": "MA Wen-hui",
                "org": " Laizhou Mingbo Fishery Co. Ltd. Yantai,Shandong ,China"
            },
            {
                "name": "SUN Fang-fang",
                "org": " Laizhou Mingbo Fishery Co. Ltd. Yantai,Shandong ,China"
            }
        ],
        "venue": "modern fisheries information",
        "keywords": [
            "artificial breeding",
            "seven band groupers",
            "breeding biology",
            "progress of the study"
        ],
        "year": 2011
    },
    "bVbAFVv3": {
        "id": "bVbAFVv3",
        "title": "Observation of the larval feeding habits of seven-band grouper Epinephelus septem fasciatus",
        "authors": [
            {
                "name": "WU Lei-ming",
                "org": "College of Fisheries and Life Sciences, Shanghai Ocean University, "
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "ZHAI Jian-ming",
                "org": "Mingbo Fisheries Limited Corporation, Laizhou,Yantai "
            },
            {
                "name": "YANG Zhi",
                "org": "Tianyuan Fisheries Limited Corporation, Yantai "
            },
            {
                "name": "LI Yan-lu",
                "org": "College of Fisheries and Life Sciences, Shanghai Ocean University, ;Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "MA Wen-hui",
                "org": "Mingbo Fisheries Limited Corporation, Laizhou,Yantai "
            },
            {
                "name": "SONG Zhen-xin",
                "org": "College of Fisheries and Life Sciences, Shanghai Ocean University, ;Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "SUN Tao",
                "org": "Tianyuan Fisheries Limited Corporation, Yantai "
            },
            {
                "name": "PANG Zun-fang",
                "org": "Mingbo Fisheries Limited Corporation, Laizhou,Yantai "
            },
            {
                "name": "SUN Fang-fang",
                "org": "Mingbo Fisheries Limited Corporation, Laizhou,Yantai "
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Seven-band grouper Larvae Feeding habit"
        ],
        "year": 2013
    },
    "1VmwebaJ": {
        "id": "1VmwebaJ",
        "title": "Ultrastructure of spermatozoa in Epinephelus septemfasciatus",
        "authors": [
            {
                "name": "LIAO Guang-yong",
                "org": "South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China;College of Fisheries and Life Science,Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "OU You-jun",
                "org": "South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China"
            },
            {
                "name": "LI Jia-er",
                "org": "South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "ZHUANG Zhi-meng",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            }
        ],
        "venue": "journal of shanghai ocean university",
        "keywords": [
            "ultrastructure",
            "spermatozoa",
            "sevenband grouper Epinephelus septemfasciatus"
        ],
        "year": 2011
    },
    "eb87NxMd": {
        "id": "eb87NxMd",
        "title": "THE MORPHOLOGICAL CHANGE UNDER SALINITY STRESS IN DEVELOPMENT OF YOLK SAC LARVAE OF EPINEPHELUS MALABARICUS",
        "authors": [
            {
                "name": "SHI Zhao-Hong",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai,"
            },
            {
                "name": "CHEN Bo",
                "org": "Fisheries Institute of Zhoushan City,Zhejiang Province,Zhoushan,"
            },
            {
                "name": "PENG Shi-Ming",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai,"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao,"
            },
            {
                "name": "WANG Jian-Gang",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai,"
            },
            {
                "name": "FU Rong-Bing",
                "org": "Fisheries Institute of Zhoushan City,Zhejiang Province,Zhoushan,"
            },
            {
                "name": "LIU Min-Hai",
                "org": "Fisheries Institute of Zhoushan City,Zhejiang Province,Zhoushan,"
            }
        ],
        "venue": "oceanologia et limnologia sinica",
        "keywords": [
            "Embryo",
            "Salinity stress",
            "Morphology",
            "Epinephelus malabaricus",
            "Post-embryonic larvae"
        ],
        "year": 2008
    },
    "iM7FLddm": {
        "id": "iM7FLddm",
        "title": "Genetic diversity analysis of silver pomfret (Pampus argenteus) in the East China Sea based on mtDNA D-loop sequence",
        "authors": [
            {
                "name": "PENG Shi-ming",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai ,China"
            },
            {
                "name": "SHI Zhao-hong",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": " Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "HOU Jun-li",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai ,China"
            }
        ],
        "venue": "marine sciences",
        "keywords": [
            "D-loop sequence",
            "East China Sea",
            "Pampus argenteus",
            "mitochondrial DNA"
        ],
        "year": 2010
    },
    "InJR8pPv": {
        "id": "InJR8pPv",
        "title": "Nutritional components analysis and nutritive value evaluation in Epinephelus septemfasciatus muscles",
        "authors": [
            {
                "name": "CHENG Bo",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao ; College of Animal Science, Agricultural University of Xinjiang, Wulumuqi "
            },
            {
                "name": "CHEN Chao",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "WANG Yin-geng",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "LI Sheng-zhong",
                "org": " College of Animal Science, Agricultural University of Xinjiang, Wulumuqi "
            },
            {
                "name": "YU Hong",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "ZHANG Jia-song",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao "
            },
            {
                "name": "YANG Zhi",
                "org": " Tian Yuan Fisheries Corporation of Yantan, "
            },
            {
                "name": "YU Wen-song",
                "org": " Fishery Research Institute of Yantan, "
            },
            {
                "name": "QU Jiang-bo",
                "org": " Tian Yuan Fisheries Corporation of Yantan, "
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Epinephelus septemfasciatus Muscle Nutritional components Nutritional evaluation"
        ],
        "year": 2009
    },
    "xTmatwL5": {
        "id": "xTmatwL5",
        "title": "Preliminary studies on embryonic development and morphology of the yolk-sac larvae of Centropristis striata Linnaeus",
        "authors": [
            {
                "name": "JIA Rui-jin",
                "org": " College of Fisheries and Life Science,Shanghai Ocean University,; Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "WANG Lu",
                "org": " Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "ZHAO Cong-ming",
                "org": " Tianjin Leadar Marine Resources Development Co,Ltd,"
            },
            {
                "name": "GONG Guang-ye",
                "org": " College of Fisheries and Life Science,Shanghai Ocean University,; Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "SUN Shu-guang",
                "org": " Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "YU Hong",
                "org": " Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "WANG Yan-huai",
                "org": " Tianjin Leadar Marine Resources Development Co,Ltd,"
            },
            {
                "name": "SUN Tao",
                "org": " Yantai Tianyuan aquaculture Co.,Ltd,"
            },
            {
                "name": "WANG He",
                "org": " Tianjin Leadar Marine Resources Development Co,Ltd,"
            },
            {
                "name": "CHEN Chao",
                "org": " Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Centropristis striata Linnaeus Embryonic developmentYolk-sac larvae Fertilized egg"
        ],
        "year": 2012
    },
    "C5WKPSHa": {
        "id": "C5WKPSHa",
        "title": "Relation of environmental factor and spermatozoa vitality of Epinephelus septemfasciatus",
        "authors": [
            {
                "name": "OU You-jun",
                "org": "South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China"
            },
            {
                "name": "LIAO Guang-yong",
                "org": "South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China;College of Fisheries and Life Science,Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "LI Jia-er",
                "org": "South China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Guangzhou ,China"
            },
            {
                "name": "ZHUANG Zhi-meng",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "LIU Xue-zhou",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "YANG Zhi",
                "org": "Yantai Tianyuan Aquatic Limited Corporation,Yantai ,China"
            },
            {
                "name": "SUN Tao",
                "org": "Yantai Tianyuan Aquatic Limited Corporation,Yantai ,China"
            }
        ],
        "venue": "marine environmental science",
        "keywords": [
            "environmental factors",
            "Epinephelus septemfasciatus",
            "spermatozoa",
            "activation"
        ],
        "year": 2011
    },
    "U3aoVnT2": {
        "id": "U3aoVnT2",
        "title": "Effect of salinity on embryonic development and post-embryonic larval growth of Epinephelus septemfasciatus",
        "authors": [
            {
                "name": "ZHAO Ming",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,; Fishery College,Ocean University of China,Qingdao "
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "LIU Xue-zhou",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "ZHUANG Zhi-meng",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "XU Yong-jiang",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "XUE Bao-gui",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "YANG Zhi",
                "org": " Tianyuan Aquaculture Limited Company of Yantai Development Area,26400"
            },
            {
                "name": "WANG Yan-yan",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "QU Jiang-bo",
                "org": " Tianyuan Aquaculture Limited Company of Yantai Development Area,26400"
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Epinephelus septemfasciatus Embryonic development Salinity SAI Starvation-resisting ability"
        ],
        "year": 2011
    },
    "sqiQO4de": {
        "id": "sqiQO4de",
        "title": "The current research and prospect on the nutritional and environmental factors of Mugil cephalus and Liza haematocheila",
        "authors": [
            {
                "name": "PENG Shi-ming",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai ,China"
            },
            {
                "name": "SHI Zhao-hong",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            }
        ],
        "venue": "marine fisheries",
        "keywords": [
            "environmental factors",
            "Liza haematocheila",
            "Mugil cephalus",
            "nutritional factors"
        ],
        "year": 2008
    },
    "WvWjiv0a": {
        "id": "WvWjiv0a",
        "title": "EMBRYONIC AND POST-EMBRYONIC DEVELOPMENT OF BARFIN FLOUNDER VERASPER MOSERI",
        "authors": [
            {
                "name": "LIU Xue-Zhou",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, "
            },
            {
                "name": "XU Yong-Jiang",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, "
            },
            {
                "name": "LIU Xin-Fu",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, "
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, "
            },
            {
                "name": "WANG Yan-Yan",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, "
            },
            {
                "name": "MA Ai-Jun",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resource, Ministry of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fisheries Sciences, Qingdao, "
            }
        ],
        "venue": "oceanologia et limnologia sinica",
        "keywords": [
            "morphological characters",
            "verasper moseri",
            "embryonic development",
            "post-embryonic development and growth",
            "aquatic animals",
            "metamorphosis",
            "morphology",
            "embryos"
        ],
        "year": 2009
    },
    "GcV6QSli": {
        "id": "GcV6QSli",
        "title": "STUDIES ON THE FEEDING BEHAVIOR AND MORPHOLOGICAL DEVELOPMENTS OF EPINEPHELUS MOARA IN EARLY DEVELOPMENT STAGES",
        "authors": [
            {
                "name": "LU Li-Jun",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences;Shanghai Ocean University,Shanghai,"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "MA Ai-Jun",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "ZHAI Jie-Ming",
                "org": "Laizhou Mingbo Aquatic Products Co.Ltd.,Yantai,"
            },
            {
                "name": "WANG Xin-An",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "LI Wei-Ye",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            }
        ],
        "venue": "oceanologia et limnologia sinica",
        "keywords": [
            "Feed",
            "juvenile and young fish",
            "Epinephelus moara",
            "Morphological development",
            "Larval"
        ],
        "year": 2011
    },
    "Bal0hPfu": {
        "id": "Bal0hPfu",
        "title": "Turbot Scophthalmus maximus: stocking density on growth, pigmentation and feed conversion",
        "authors": [
            {
                "name": "MA Aijun",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao , China"
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao , China"
            },
            {
                "name": "LEI Jilin",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao , China"
            },
            {
                "name": "CHEN Siqing",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao , China"
            },
            {
                "name": "ZHUANG Zhimeng",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao , China"
            },
            {
                "name": "WANG Yingeng",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture,Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao , China"
            }
        ],
        "venue": "\u4e2d\u56fd\u6d77\u6d0b\u6e56\u6cbc\u5b66\u62a5(\u82f1\u6587\u7248)",
        "keywords": [
            "turbot (Scophthalmus maximus)",
            "feed coefficient",
            "stocking density",
            "pigmentation improvement",
            "growth"
        ],
        "year": 2006
    },
    "xwwI2O32": {
        "id": "xwwI2O32",
        "title": "Development of Neural Embryo and Yolk Sac Larvae of Epinephelus septemfasciatus",
        "authors": [
            {
                "name": "XIE Jing",
                "org": "South China Sea Fisheries Research Institute,CAFS,Guangzhou ,Guangdong,China,2.Shanghai Fisheries University,shanghai ,China"
            },
            {
                "name": "OU Youjun",
                "org": "South China Sea Fisheries Research Institute,CAFS,Guangzhou ,Guangdong,China,2.Shanghai Fisheries University,shanghai ,China"
            },
            {
                "name": "LI Jiaer",
                "org": "South China Sea Fisheries Research Institute,CAFS,Guangzhou ,Guangdong,China,2.Shanghai Fisheries University,shanghai ,China"
            },
            {
                "name": "HE Yongliang",
                "org": "South China Sea Fisheries Research Institute,CAFS,Guangzhou ,Guangdong,China,2.Shanghai Fisheries University,shanghai ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,Shandong,China"
            }
        ],
        "venue": "marine science bulletin",
        "keywords": [
            "development",
            "embryo",
            "yolk-sac larva",
            "E.septemfasciatus"
        ],
        "year": 2009
    },
    "37DqAV0D": {
        "id": "37DqAV0D",
        "title": "Embryonic and morphological development in larva,juvenile,and young stages of F1 by Epinephelus moara(\u2640)\u00d7E.septemfasciatus(\u2642)",
        "authors": [
            {
                "name": "LI Yanlu",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "WANG Qingyin",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "ZHAI Jieming",
                "org": "Laizhou Mingbo Fisheries Limited Company,Yantai ,China"
            },
            {
                "name": "WU Leiming",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "MA Wenhui",
                "org": "Laizhou Mingbo Fisheries Limited Company,Yantai ,China"
            },
            {
                "name": "SONG Zhenxin",
                "org": "College of Fisheries and Science,Shanghai Ocean University,Shanghai ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "SUN Fangfang",
                "org": "Laizhou Mingbo Fisheries Limited Company,Yantai ,China"
            }
        ],
        "venue": "journal of fishery sciences of china",
        "keywords": [
            "embryonic development",
            "Epinephelus moara",
            "crossbreed F1",
            "morphological ob-servation",
            "E.septemfasciatus"
        ],
        "year": 2012
    },
    "p1btssu8": {
        "id": "p1btssu8",
        "title": "The complete mitochondrial genome of the juvenile Atlantic bluefin tuna Thunnus thynnus (Perciformes, Scombridae).",
        "authors": [
            {
                "name": "Li Yanlu",
                "org": "Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences , Qingdao , China ."
            },
            {
                "name": "Chen Chao"
            },
            {
                "name": "Yu Hong"
            },
            {
                "name": "Peng Shiming"
            },
            {
                "name": "Sun Shuguang"
            },
            {
                "name": "Wang Lu"
            },
            {
                "name": "Meng Xiangjun"
            },
            {
                "name": "Huang Ying"
            },
            {
                "name": "Kong Xiangdi"
            }
        ],
        "venue": "mitochondrial dna",
        "keywords": [
            "juvenile fish",
            "mitochondrial genome",
            "next generation sequencing"
        ],
        "year": 2014
    },
    "nbsLn9zy": {
        "id": "nbsLn9zy",
        "title": "Changes in ultrastructures of Takifugu rubripes spermatozoa before and after cryopreservation",
        "authors": [
            {
                "name": "YU Hai-tao",
                "org": "Fishery College,Ocean University of China,Qingdao ,China"
            },
            {
                "name": "ZHANG Xiu-mei",
                "org": "Fishery College,Ocean University of China,Qingdao ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "LI Hui",
                "org": "Shandong Huaxinhaida Halobios Company Limited,Weihai ,%%#China"
            }
        ],
        "venue": "marine sciences",
        "keywords": [
            "ultrastructure",
            "Takifugu rubripes",
            "cryopreservation",
            "spermatozoon"
        ],
        "year": 2007
    },
    "Te92gKot": {
        "id": "Te92gKot",
        "title": "Preparation of Compound Seafood Condiments from Shellfish-processed Wastes",
        "authors": [
            {
                "name": "CHEN Chao",
                "org": "Biological Department of Medical College,Qingdao University,Qingdao ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "WEI Yu-xi",
                "org": "Biological Department of Medical College,Qingdao University,Qingdao ,China"
            },
            {
                "name": "LIU Hui-hui",
                "org": "Biological Department of Medical College,Qingdao University,Qingdao ,China"
            },
            {
                "name": "YIN Bang-zhong",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "ZHAO Ling",
                "org": "Biological Department of Medical College,Qingdao University,Qingdao ,China"
            },
            {
                "name": "LIU Qi",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            }
        ],
        "venue": "food science",
        "keywords": [
            "enzymatic hydrolysis",
            "clam juice",
            "degree of hydrolysis",
            "scallop mantle",
            "compound seafood condiment",
            "oyster juice"
        ],
        "year": 2010
    },
    "8WBRB8PB": {
        "id": "8WBRB8PB",
        "title": "MORPHOLOGICAL VARIATION IN TWO WILD POPULATIONS OF SEVENBAND GROUPER (EPINEPHELUS SEPTEMFASCIATUS)",
        "authors": [
            {
                "name": "WANG Xin-An",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Science"
            },
            {
                "name": "MA Ai-Jun",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Science"
            },
            {
                "name": "CHEN Chao",
                "org": " Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Science"
            },
            {
                "name": "YANG Zhi",
                "org": " Yantai Tianyuan Aquatic Limited Corporation, Yantai, "
            },
            {
                "name": "QU Jiang-Bo",
                "org": " Yantai Tianyuan Aquatic Limited Corporation, Yantai, "
            }
        ],
        "venue": "oceanologia et limnologia sinica",
        "keywords": [
            "Morphological difference",
            "Sevenband grouper Epinephelus septemfasciatus",
            "Analysis",
            "Wild populations"
        ],
        "year": 2008
    },
    "FZ54dOa3": {
        "id": "FZ54dOa3",
        "title": "Chromosome karyotype of sevenband grouper Epinephelus septemfasciatus (Thunberg,1793)",
        "authors": [
            {
                "name": "ZHONG Shengping",
                "org": "College of Oceanography and Environmental Science,Xiamen University,Xiamen ,China;Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "WANG Jun",
                "org": "College of Oceanography and Environmental Science,Xiamen University,Xiamen ,China"
            },
            {
                "name": "LIU Zhihong",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "LIU Shufang",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "ZHU Ling",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            },
            {
                "name": "ZHUANG Zhimeng",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences"
            }
        ],
        "venue": "journal of fishery sciences of china",
        "keywords": [
            "Epinephelus septemfasciatus",
            "karyotype",
            "chromosome"
        ],
        "year": 2010
    },
    "yu472C2r": {
        "id": "yu472C2r",
        "title": "Influence of low-temperature stress on serum biochemical parameters in juvenile Epinephelus septemfasciatus",
        "authors": [
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "SHI Zhao-hong",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai ,China"
            },
            {
                "name": "XUE Bao-gui",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China;College of Fisheries and Life Science,Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "WANG Lu",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            },
            {
                "name": "LI Yan-lu",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China;College of Fisheries and Life Science,Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "WU Lei-ming",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China;College of Fisheries and Life Science,Shanghai Ocean University,Shanghai ,China"
            },
            {
                "name": "QU Jiang-bo",
                "org": "Yantai Tianyuan Aquatic Limited Corporation,Yantai ,China"
            },
            {
                "name": "Ma Ai-jun",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            }
        ],
        "venue": "journal of fisheries of china",
        "keywords": [
            "Epinephelus septemfasciatus",
            "serum ion",
            "metabolic enzymes",
            "low-temperature stress",
            "biochemical parameters"
        ],
        "year": 2012
    },
    "ld2voFq7": {
        "id": "ld2voFq7",
        "title": "Isolation and identification of a pathogenic bacterium from Epinephelus septemfasciatus with exophthalmic disease",
        "authors": [
            {
                "name": "CHEN Chao",
                "org": " Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "CHENG Bo",
                "org": " College of Animal Science,Agricultural University of Xinjiang,Urumqi "
            },
            {
                "name": "YU Hong",
                "org": " Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "WANG Yin-geng",
                "org": " Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "YANG Zhi",
                "org": " Yantai Tianyuan Fisheries Corporation,"
            },
            {
                "name": "SHI Cheng-yin",
                "org": " Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "QU Jiang-bo",
                "org": " Yantai Tianyuan Fisheries Corporation,"
            },
            {
                "name": "ZHAO Cong-ming",
                "org": " Lida Seawater Resources Development Corporation,Tianjin "
            },
            {
                "name": "XU Jing-rong",
                "org": " Yantai Tianyuan Fisheries Corporation,"
            },
            {
                "name": "JIANG Zhuo",
                "org": "College of Life Science and Technology,Dalian Fisheries University,"
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Epinephelus septemfasciatus Exophthalmic disease Pathogenic bacteria Vibrio harveyi"
        ],
        "year": 2010
    },
    "r7e5BFMB": {
        "id": "r7e5BFMB",
        "title": "Development and growth of embryos and early larvae of Epinephelus septem fasciatus",
        "authors": [
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "ZHAO Ming",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,;Fishery College, Ocean University of China,Qingdao "
            },
            {
                "name": "LIU Xue-zhou",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "WANG Lu",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agriculture, Qingdao Key Laboratory for Marine Fish Breeding and Biotechnology, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences,"
            },
            {
                "name": "YANG Zhi",
                "org": "Tianyuan Aquaculture Limited Company of Yantai Development Area, "
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Epinephelus septemfasciatus Development of embryo Post-embryonic develonment Starvation"
        ],
        "year": 2011
    },
    "8HbT80ma": {
        "id": "8HbT80ma",
        "title": "The complete mitochondrial genome of the Southern bluefin tuna Thunnus maccoyii.",
        "authors": [
            {
                "name": "Li Yanlu",
                "org": "Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences , Qingdao , China ."
            },
            {
                "name": "Chen Chao"
            },
            {
                "name": "Yu Hong"
            },
            {
                "name": "Peng Shiming"
            },
            {
                "name": "Sun Shuguang"
            },
            {
                "name": "Wang Lu"
            },
            {
                "name": "Meng Xiangjun"
            },
            {
                "name": "Huang Ying"
            },
            {
                "name": "Kong Xiangdi"
            }
        ],
        "venue": "mitochondrial dna",
        "keywords": [
            "mitochondrial genome",
            "thunnus maccoyii",
            "next generation sequencing"
        ],
        "year": 2014
    },
    "CKchpg32": {
        "id": "CKchpg32",
        "title": "The effects of starvation and refeeding on the growth,biochemical composition and behavior of juvenile grouper Epinephelus marlabaricus",
        "authors": [
            {
                "name": "LIU Min-hai",
                "org": "Zhoushan Fisheries Research Institute of Zhejiang Province,Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan ,China"
            },
            {
                "name": "PENG Zhi-lan",
                "org": "Zhoushan Fisheries Research Institute of Zhejiang Province,Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan ,China"
            },
            {
                "name": "SHI Zhao-hong",
                "org": "East China Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key and Open Laboratory of Marine and Estuarine Fisheries,Ministry of Agriculture,Shanghai ,China"
            },
            {
                "name": "LUO Hai-zhong",
                "org": "Zhoushan Fisheries Research Institute of Zhejiang Province,Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan ,China"
            },
            {
                "name": "MAO Zhi-zeng",
                "org": "Zhoushan Fisheries Research Institute of Zhejiang Province,Aquaculture Research and Promotion Center,Zhejiang Marine Development Research Institute,Zhoushan ,China"
            },
            {
                "name": "CHEN Chao",
                "org": "Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao ,China"
            }
        ],
        "venue": "marine fisheries",
        "keywords": [
            "behavior",
            "Epinephelus malabaricus",
            "starvation",
            "biochemical composition",
            "refeeding",
            "growth"
        ],
        "year": 2009
    },
    "YPWNMNCM": {
        "id": "YPWNMNCM",
        "title": "The complete mitochondrial genome of the juvenile Pacific bluefin tuna Thunnus orientalis (Perciformes, Scombridae).",
        "authors": [
            {
                "name": "Chen Chao",
                "org": "Fisheries College, Ocean University of China , Qingdao , China ."
            },
            {
                "name": "Li Yanlu"
            },
            {
                "name": "Yu Hong"
            },
            {
                "name": "Peng Shiming"
            },
            {
                "name": "Sun Shuguang"
            },
            {
                "name": "Wang Lu"
            },
            {
                "name": "Meng Xiangjun"
            },
            {
                "name": "Huang Ying"
            },
            {
                "name": "Kong Xiangdi"
            }
        ],
        "venue": "mitochondrial dna",
        "keywords": [
            "next generation sequencing",
            "mitochondrial genome",
            "juvenile fish"
        ],
        "year": 2014
    },
    "LCRaR06z": {
        "id": "LCRaR06z",
        "title": "Characteristics of morphological development and growth of Epinephelus septemfasciatus larvae and juvenile",
        "authors": [
            {
                "name": "OU You-jun"
            },
            {
                "name": "LIAO Guang-yong"
            },
            {
                "name": "LI Jia-er"
            },
            {
                "name": "SU Hui"
            },
            {
                "name": "CHEN Chao"
            }
        ],
        "venue": "journal of applied oceanography",
        "keywords": [
            "morphological development",
            "marine biology",
            "Epinephelus septemfasciatus",
            "larvae and juvenile",
            "growth"
        ],
        "year": 2013
    },
    "YONnNbB8": {
        "id": "YONnNbB8",
        "title": "Analysis of nutrient components in the muscle of Humphead wrasse Cheilinus undulates",
        "authors": [
            {
                "name": "GAO Chun-ren",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fishery Resources,Ministry of Agriculture ,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "YU Hong",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fishery Resources,Ministry of Agriculture ,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory for Sustainable Utilization of Marine Fishery Resources,Ministry of Agriculture ,Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Humphead wrasse Cheilinus undulates MuscleNutrient components Analysis"
        ],
        "year": 2010
    },
    "l4QzFopP": {
        "id": "l4QzFopP",
        "title": "Embryonic development and morphological characteristics of larval,juvenile and young Kelp bass,Epinephelus moara",
        "authors": [
            {
                "name": "SONG Zhen-xin",
                "org": "College of Fisheries and Life Science,Shanghai Ocean University,;Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture, Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "CHEN Chao",
                "org": "Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture, Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "ZHAI Jie-ming",
                "org": "Laizhou Mingbo Fisheries Limited Corporation,"
            },
            {
                "name": "LI Yan-lu",
                "org": "College of Fisheries and Life Science,Shanghai Ocean University,;Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture, Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "MA Wen-hui",
                "org": "Laizhou Mingbo Fisheries Limited Corporation,"
            },
            {
                "name": "WANG Lu",
                "org": "Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture, Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            },
            {
                "name": "PANG Zun-fang",
                "org": "Laizhou Mingbo Fisheries Limited Corporation,"
            },
            {
                "name": "WU Lei-ming",
                "org": "College of Fisheries and Life Science,Shanghai Ocean University,;Key Laboratory of Sustainable Development of Marine Fisheries,Ministry of Agriculture, Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Qingdao "
            }
        ],
        "venue": "progress in fishery sciences",
        "keywords": [
            "Kelp bass Embryonic development Larvae JuvenileYoung fish Morphological characteristics"
        ],
        "year": 2012
    },
    "bSvd8qER": {
        "authors": [
            {
                "name": "Zi Lin Gong",
                "org": "College of Life Science and Technology, Harbin Normal University"
            },
            {
                "name": "Ying Chen",
                "org": "College of Life Science and Technology, Harbin Normal University"
            },
            {
                "name": "Yan Yan",
                "org": "College of Life Science and Technology, Harbin Normal University"
            },
            {
                "name": "Si Ying Pei",
                "org": "College of Life Science and Technology, Harbin Normal University"
            },
            {
                "name": "Di Wu",
                "org": "College of Life Science and Technology, Harbin Normal University"
            },
            {
                "name": "Miao Zhang",
                "org": "College of Life Science and Technology, Harbin Normal University"
            },
            {
                "name": "Qi Wang",
                "org": "College of Life Science and Technology, Harbin Normal University"
            }
        ],
        "title": "Toxicity of three heavy metal pollutants of the pharmaceutical wastewater to paramecium caudatum",
        "abstract": "In order to provide information for biological monitoring of environmental pollution and help people to develop pharmaceutical wastewater pollutant monitoring and emission standard, in this paper, acute toxicity experiments of three heavy metal pollutants, Zn",
        "keywords": [
            "Acute toxicity",
            "Heavy metal",
            "Paramecium caudatum",
            "Pharmaceutical wastewater",
            "Population growth curve"
        ],
        "venue": "Advanced Materials Research",
        "year": 2014,
        "id": "bSvd8qER"
    },
    "of14S73X": {
        "authors": [
            {
                "name": "C. Yang",
                "org": "School of Management"
            },
            {
                "name": "Sunjinjuan",
                "org": "School of Management"
            }
        ],
        "title": "A variation of the inverse shortest paths problem",
        "abstract": "In this paper we consider a kind of the inverse shortest paths problem in which we want to adjust the given weights of arcs as less as possible so that a set of given paths become shortest ones from their sources to sinks, under an additional requirement that the weights of all arcs initiated from the same node must be adjusted by the same amount. We first formulate this problem into an LP model, them prove it can be solved in strongly polynomial time.",
        "keywords": [
            "Polynomial algorithm",
            "Shortest path",
            "Variation"
        ],
        "venue": "Wuhan Gongye Daxue Xuebao/Journal of Wuhan University of Technology",
        "year": 2001,
        "id": "of14S73X"
    },
    "612jmnLU": {
        "id": "612jmnLU",
        "title": "ELECTRONIC PARTS DEVICE",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kenzo takemura",
                "org": ""
            },
            {
                "name": "itsuo watanabe",
                "org": ""
            },
            {
                "name": "akira nagai",
                "org": ""
            },
            {
                "name": "osamu watanabe",
                "org": ""
            },
            {
                "name": "kazuyoshi kojima",
                "org": ""
            },
            {
                "name": "akishi nakaso",
                "org": ""
            },
            {
                "name": "kazunori yamamoto",
                "org": ""
            },
            {
                "name": "yoshiyuki tsuru",
                "org": ""
            },
            {
                "name": "teiichi inada",
                "org": ""
            },
            {
                "name": "yasushi shimada",
                "org": ""
            }
        ],
        "venue": "",
        "year": 1999
    },
    "fibjOWp1": {
        "id": "fibjOWp1",
        "title": "Electronic component parts device",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "kenzo takemura",
                "org": ""
            },
            {
                "name": "itsuo watanabe",
                "org": ""
            },
            {
                "name": "akira nagai",
                "org": ""
            },
            {
                "name": "osamu watanabe",
                "org": ""
            },
            {
                "name": "kazuyoshi kojima",
                "org": ""
            },
            {
                "name": "akishi nakaso",
                "org": ""
            },
            {
                "name": "kazunori yamamoto",
                "org": ""
            },
            {
                "name": "yoshiyuki tsuru",
                "org": ""
            },
            {
                "name": "teiichi inada",
                "org": ""
            },
            {
                "name": "yasushi shimada",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "7K7ZFexF": {
        "id": "7K7ZFexF",
        "title": "Method of production of semiconductor device",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "aizou kaneda",
                "org": ""
            },
            {
                "name": "masaaki yasuda",
                "org": ""
            },
            {
                "name": "itsuo watanabe",
                "org": ""
            },
            {
                "name": "tomohisa ohta",
                "org": ""
            },
            {
                "name": "fumio inoue",
                "org": ""
            },
            {
                "name": "yoshiaki tsubomatsu",
                "org": ""
            },
            {
                "name": "toshio yamazaki",
                "org": ""
            },
            {
                "name": "hiroto ohata",
                "org": ""
            },
            {
                "name": "kenzo takemura",
                "org": ""
            },
            {
                "name": "akira nagai",
                "org": ""
            },
            {
                "name": "osamu watanabe",
                "org": ""
            },
            {
                "name": "naoyuki shiozawa",
                "org": ""
            },
            {
                "name": "kazuyoshi kojima",
                "org": ""
            },
            {
                "name": "toshiaki tanaka",
                "org": ""
            },
            {
                "name": "kazunori yamamoto",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2001
    },
    "CGxFjtp9": {
        "id": "CGxFjtp9",
        "title": "Connection sheet and electrode connection structure for electrically interconnecting electrodes facing each other, and method using the connection sheet",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "isao tsukagoshi",
                "org": ""
            },
            {
                "name": "yukihisa hirosawa",
                "org": ""
            },
            {
                "name": "kouji kobayashi",
                "org": ""
            },
            {
                "name": "tomohisa ohta",
                "org": ""
            },
            {
                "name": "hiroshi matsuoka",
                "org": ""
            },
            {
                "name": "itsuo watanabe",
                "org": ""
            },
            {
                "name": "kenzo takemura",
                "org": ""
            },
            {
                "name": "naoyuki shiozawa",
                "org": ""
            },
            {
                "name": "osamu watanabe",
                "org": ""
            },
            {
                "name": "kazuyoshi kojima",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2002
    },
    "mzhnOaon": {
        "id": "mzhnOaon",
        "title": "Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.",
        "abstract": "Obesity and its related metabolic disorders are closely correlated with gut dysbiosis. Montmorillonite is a common medicine used to treat diarrhea. We have previously found that dietary lipid adsorbent-montmorillonite (DLA-M) has an unexpected role in preventing obesity. The aim of this study was to further investigate whether DLA-M regulates intestinal absorption and gut microbiota to prevent obesity-related metabolic disorders. Here, we show that DLA-M absorbs free fatty acids (FFA) and endotoxins in vitro and in vivo. Moreover, the combination of fluorescent tracer technique and polarized light microscopy showed that DLA-M crystals immobilized BODIPY\u00ae FL C16 and FITC-LPS, respectively, in the digestive tract in situ. HFD-fed mice treated with DLA-M showed mild changes in the composition of the gut microbiota, particularly increases in short-chain fatty acids (SCFA)-producing Blautia bacteria and decreases in endotoxin-producing Desulfovibrio bacteria, these changes were positively correlated with obesity and inflammation. Our results indicated that DLA-M immobilizes FFA and endotoxins in the digestive tract via the adsorption-excretion axis and DLA-M may potentially be used as a prebiotic to prevent intestinal dysbiosis and obesity-associated metabolic disorders in obese individuals.",
        "keywords": [
            "Endotoxins",
            "Free fatty acids",
            "Gut microbiota",
            "Metabolic disorders",
            "Montmorillonite",
            "Obesity"
        ],
        "authors": [
            {
                "name": "Pengfei Xu",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Fan Hong",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Jialin Wang",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Yusheng Cong",
                "org": "Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China."
            },
            {
                "name": "Shu Dai",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Sheng Wang",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Jing Wang",
                "org": "Department of Biology Science and Technology, Baotou Teacher's College, Baotou 014030, China."
            },
            {
                "name": "Xi Jin",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Fang Wang",
                "org": "Department of Medical Genetics and Cell Biology, School of Basic Sciences, Guangzhou Medical University, Guangzhou 511436, China."
            },
            {
                "name": "Jin Liu",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Yonggong Zhai",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China. Electronic address: ygzhai@bnu.edu.cn."
            }
        ],
        "venue": "EBioMedicine",
        "year": 2017
    },
    "6aU7KQTQ": {
        "id": "6aU7KQTQ",
        "title": "Preventive obesity agent montmorillonite adsorbs dietary lipids and enhances lipid excretion from the digestive tract",
        "abstract": "A Nature Research Journal",
        "keywords": "",
        "authors": [
            {
                "name": "Pengfei Xu",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Shu Dai",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Jin Liu",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Yonggong Zhai",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Jing Wang",
                "org": "Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Jun Zhang",
                "org": "Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Yonggong Zhai",
                "org": "Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China"
            },
            {
                "name": "Fang Wang",
                "org": "Department of Medical Genetics and Cell Biology, School of Basic Sciences, Guangzhou Medical University, Guangzhou 511436, China"
            },
            {
                "name": "Jing Wang",
                "org": "Department of Biology Science and Technology, Baotou Teacher\u2019s College, Baotou 014030, China"
            }
        ],
        "venue": "Scientific Reports",
        "year": 2016
    },
    "phg6Scev": {
        "id": "phg6Scev",
        "title": "Microbiome Remodeling via the Montmorillonite Adsorption-Excretion Axis Prevents Obesity-related Metabolic Disorders.",
        "abstract": "Obesity and its related metabolic disorders are closely correlated with gut dysbiosis. Montmorillonite is a common medicine used to treat diarrhea. We have previously found that dietary lipid adsorbent-montmorillonite (DLA-M) has an unexpected role in preventing obesity. The aim of this study was to further investigate whether DLA-M regulates intestinal absorption and gut microbiota to prevent obesity-related metabolic disorders. Here, we show that DLA-M absorbs free fatty acids (FFA) and endotoxins in vitro and in vivo. Moreover, the combination of fluorescent tracer technique and polarized light microscopy showed that DLA-M crystals immobilized BODIPY\u00ae FL C16 and FITC-LPS, respectively, in the digestive tract in situ. HFD-fed mice treated with DLA-M showed mild changes in the composition of the gut microbiota, particularly increases in short-chain fatty acids (SCFA)-producing Blautia bacteria and decreases in endotoxin-producing Desulfovibrio bacteria, these changes were positively correlated with obesity and inflammation. Our results indicated that DLA-M immobilizes FFA and endotoxins in the digestive tract via the adsorption-excretion axis and DLA-M may potentially be used as a prebiotic to prevent intestinal dysbiosis and obesity-associated metabolic disorders in obese individuals.",
        "keywords": [
            "Endotoxins",
            "Free fatty acids",
            "Gut microbiota",
            "Metabolic disorders",
            "Montmorillonite",
            "Obesity"
        ],
        "authors": [
            {
                "name": "Pengfei Xu",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Fan Hong",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Jialin Wang",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Yusheng Cong",
                "org": "Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou 311121, China."
            },
            {
                "name": "Shu Dai",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Sheng Wang",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Jing Wang",
                "org": "Department of Biology Science and Technology, Baotou Teacher's College, Baotou 014030, China."
            },
            {
                "name": "Xi Jin",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Fang Wang",
                "org": "Department of Medical Genetics and Cell Biology, School of Basic Sciences, Guangzhou Medical University, Guangzhou 511436, China."
            },
            {
                "name": "Jin Liu",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China."
            },
            {
                "name": "Yonggong Zhai",
                "org": "Beijing Key Laboratory of Gene Resource and Molecular Development, College of Life Sciences, Beijing Normal University, Beijing 100875, China; Key Laboratory for Cell Proliferation and Regulation Biology of State Education Ministry, College of Life Sciences, Beijing Normal University, Beijing 100875, China. Electronic address: ygzhai@bnu.edu.cn."
            }
        ],
        "venue": "EBioMedicine",
        "year": 2017
    },
    "04YBB8uv": {
        "id": "04YBB8uv",
        "title": "Effect of Boron on the Hot Ductility of Low-Carbon Nb-Ti-Microalloyed Steel",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Cheng-bin Shi",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB)"
            },
            {
                "name": "Wei-jian Liu",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB)"
            },
            {
                "name": "Jing Li",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB)"
            },
            {
                "name": "Lu Yu",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB)"
            }
        ],
        "venue": "Materials Transactions",
        "year": 2016
    },
    "cKuzuLcg": {
        "id": "cKuzuLcg",
        "title": "Formation and Evolution of Non-Metallic Inclusions in Calcium Treatment H13 Steel during Electroslag Remelting Process",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Wang",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing"
            },
            {
                "name": "Jing Li",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing"
            },
            {
                "name": "Chengbin Shi",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing"
            },
            {
                "name": "Yongfeng Qi",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing"
            },
            {
                "name": "Yuxiang Dai",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing"
            }
        ],
        "venue": "Isij International",
        "year": 2019
    },
    "cCEitmMj": {
        "id": "cCEitmMj",
        "title": "Effect of Micro-alloying Element Boron on the Strengthening of High-Strength Steel Q690D",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "weijian liu",
                "org": "university of science and technology beijing"
            },
            {
                "name": "jing li",
                "org": "university of science and technology beijing"
            },
            {
                "name": "chengbin shi",
                "org": "university of science and technology beijing"
            },
            {
                "name": "chunmiao wang",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2015
    },
    "T1NspT9J": {
        "id": "T1NspT9J",
        "title": "Crystallization Characteristics and In-Mold Performance of Electroslag Remelting-Type TiO2-Bearing Slag",
        "abstract": "The non-isothermal crystallization characteristics of the electroslag remelting (ESR)-type TiO2-bearing slag were studied. The effect of crystallization characteristics of the slag on the in-mold performance was verified by ESR pilot trials operating in a static mode. The results showed that increasing TiO2 content decreased the crystallization temperature and liquidus temperature of the slag and suppressed the crystallization tendency of the slag. There is no change in the types of the crystalline phases in the slag with different TiO2 contents during cooling, i.e., 11CaO\u00b77Al2O3\u00b7CaF2, CaTiO3, and CaF2. The sequence of crystal precipitation during cooling was 11CaO\u00b77Al2O3\u00b7CaF2 to CaTiO3, and then CaF2 with increasing TiO2 content from 4.2 to 12.6 mass pct. With adding 16.8 mass pct TiO2 in the slag, the precipitation of 11CaO\u00b77Al2O3\u00b7CaF2 and CaTiO3 took place simultaneously, followed by CaF2. With the increase in the TiO2 content from 4.2 to 16.8 mass pct in the slag, the dominant crystalline phase changed from 11CaO\u00b77Al2O3\u00b7CaF2 to CaTiO3. The morphology of 11CaO\u00b77Al2O3\u00b7CaF2 and CaTiO3 changed from faceted and bonelike to elliptically faceted and blocky, respectively. The morphology of CaF2 were spherical in all cases, irrespective of TiO2 contents in the slag. The decrease in the crystallization tendency of the slag with increasing TiO2 contents was attributed to the decrease in the activity of CaO in the slag. The increasing of TiO2 content in the slag are favorable for providing thin slag skin and stable heat flux across the slag skin, which improved the surface quality of the as-cast ESR ingot as demonstrated by ESR pilot trials operating in a static mode.",
        "keywords": "",
        "authors": [
            {
                "name": "Dingli Zheng",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Chengbin Shi",
                "org": ""
            },
            {
                "name": "Jiantao Ju",
                "org": ""
            }
        ],
        "venue": "Metallurgical and Materials Transactions B-process Metallurgy and Materials Processing Science",
        "year": 2019
    },
    "93TBAhRs": {
        "id": "93TBAhRs",
        "title": "Two-converter steelmaking process for high silicon hot metal",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuxiang Dai",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB), Beijing, People\u2019s Republic of China"
            },
            {
                "name": "Jing Li",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB), Beijing, People\u2019s Republic of China"
            },
            {
                "name": "Chengbin Shi",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB), Beijing, People\u2019s Republic of China"
            },
            {
                "name": "Wei Yan",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB), Beijing, People\u2019s Republic of China"
            },
            {
                "name": "Chunhui Zhang",
                "org": "State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing (USTB), Beijing, People\u2019s Republic of China"
            },
            {
                "name": "Xuegang Sun",
                "org": "Xinjiang BayiIron & Steel Stock Co. Ltd, Urumqi, People\u2018s Republic of China"
            },
            {
                "name": "Hao Zhang",
                "org": "Xinjiang BayiIron & Steel Stock Co. Ltd, Urumqi, People\u2018s Republic of China"
            }
        ],
        "venue": "Ironmaking & Steelmaking",
        "year": 2019
    },
    "TXX8Y1Wc": {
        "id": "TXX8Y1Wc",
        "title": "Precipitation and growth of MnS inclusion in an austenitic hot-work die steel during ESR solidification process",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yongfeng Qi",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Chengbin Shi",
                "org": ""
            },
            {
                "name": "Hao Wang",
                "org": ""
            },
            {
                "name": "Dingli Zheng",
                "org": ""
            }
        ],
        "venue": "Revue De Metallurgie-cahiers D Informations Techniques",
        "year": 2019
    },
    "uy4pBT2L": {
        "id": "uy4pBT2L",
        "title": "Effect of SiO2 on the Crystallization Behaviors and In-Mold Performance of CaF2-CaO-Al2O3 Slags for Drawing-Ingot-Type Electroslag Remelting",
        "abstract": "The crystallization characteristics of CaF-CaO-AlO slags with varying amounts of SiO were experimentally studied. The effects of slag crystallization behaviors on the horizontal heat transfer and lubrication performance in drawing-ingot-type electroslag remelting (ESR) were also evaluated in terms of as-cast ingots surface quality and drawing-ingot operation. The results show that increasing SiO addition from 0 to 6.8 mass pct strongly suppresses the crystallization of ESR type CaF-CaO-AlO slags. The crystallization temperature of the studied slags decreases with the increase in SiO addition. The liquidus temperatures of the slags also show a decreasing trend with increasing SiO content. In CaF-CaO-AlO-(SiO) slags, faceted 11CaO\u00b77AlO\u00b7CaF crystals precipitate first during continuous cooling of the slag melts, followed by the formation of CaF at lower temperatures. 11CaO\u00b77AlO\u00b7CaF was confirmed to be the dominant crystalline phase in the studied slags. CaF-CaO-AlO slags with a small amount of SiO addition are favorable for providing sound lubrication and horizontal heat transfer in mold for drawing-ingot-type ESR, which consequently bring the improvement in the surface quality of ESR ingot and drawing-ingot operating practice as demonstrated by plant trials.",
        "keywords": [
            "Differential Scanning Calorimetry Curve",
            "Mold Flux",
            "Differential Scanning Calorimetry Measurement",
            "Slag Sample",
            "Electroslag Remelt"
        ],
        "authors": [
            {
                "name": "chengbin shi",
                "org": "university of science and technology beijing"
            },
            {
                "name": "jing li",
                "org": "university of science and technology beijing"
            },
            {
                "name": "jungwook cho",
                "org": "pohang university of science and technology"
            },
            {
                "name": "fang jiang",
                "org": ""
            },
            {
                "name": "inho jung",
                "org": "mcgill university"
            }
        ],
        "venue": "Metallurgical and Materials Transactions B",
        "year": 2015
    },
    "AuQSxdG3": {
        "id": "AuQSxdG3",
        "title": "Influence of Boron Addition on the Hot Ductility of Low-Carbon Aluminum-Killed Steel",
        "abstract": "",
        "keywords": [
            "dynamic recrystallization"
        ],
        "authors": [
            {
                "name": "weijian liu",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "chengbin shi",
                "org": ""
            },
            {
                "name": "lu yu",
                "org": ""
            }
        ],
        "venue": "Materials Transactions",
        "year": 2015
    },
    "qjG4K3gt": {
        "id": "qjG4K3gt",
        "title": "Effect of Boron and Titanium Addition on the Hot Ductility of Low-Carbon Nb-Containing Steel",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "xiangdong huo",
                "org": ""
            },
            {
                "name": "chengbin shi",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "weijian liu",
                "org": ""
            }
        ],
        "venue": "High Temperature Materials and Processes",
        "year": 2015
    },
    "6BwvqHO9": {
        "id": "6BwvqHO9",
        "title": "Quality Control of High Carbon Steel for Steel Wires",
        "abstract": "High-carbon steel wires used for bridge cables, tire reinforcement materials and cutting materials of silicon ingot for photovoltaic industry require an extremely fine diameter and high strength. Poor control of centerline segregation, inclusion and microstructure of high-carbon steel is detrimental to drawability and subsequent fatigue performance. Prof. Weiqing Chen\u2019s group at the University of Science and Technology Beijing (USTB) has been investigating the quality control of high-carbon steel through a low-cost one-stage hot rolling process since 2000. This paper reviews the main research from this group. The laboratory-scale and industrial results are presented. Intensive secondary cooling, final electromagnetic stirring (F-EMS), final permanent magnetic stirring (F-PMS), and soft reduction are investigated and applied to control centerline segregation, and the application scope is also discussed. A combination of redesign of submerged entry nozzle (SEN) and refining slag, utilization of Al-free refractory and the addition of low-melting-point compounds is studied and applied effectively to control inclusions. Measurements and mechanisms to control network cementite, martensite, banded structure and undesired texture are investigated and discussed. Integration of the above research has achieved industrial application in more than 10 steelworks and was further extended to application in spring steel, welding wire steel and some other wire rods.",
        "keywords": "",
        "authors": [
            {
                "name": "Wei Yan",
                "org": ""
            },
            {
                "name": "Weiqing Chen",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            }
        ],
        "venue": "Materials",
        "year": 2019
    },
    "mZvImR4r": {
        "id": "mZvImR4r",
        "title": "Influence of slag-changing operation during LF refining on the inclusions in 82B high carbon steel wire",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Yuxiang Dai",
                "org": ""
            },
            {
                "name": "Jing Li",
                "org": ""
            },
            {
                "name": "Chengbin Shi",
                "org": ""
            },
            {
                "name": "Wei Yan",
                "org": ""
            }
        ],
        "venue": "Revue De Metallurgie-cahiers D Informations Techniques",
        "year": 2019
    },
    "i0GHbaiS": {
        "id": "i0GHbaiS",
        "title": "Effects of Magnesium on Wear Resistance of H13 Steel",
        "abstract": "",
        "keywords": [
            "magnesium",
            "wear resistance",
            "heat treatment"
        ],
        "authors": [
            {
                "name": "liangliang wang",
                "org": ""
            },
            {
                "name": "jing li",
                "org": ""
            },
            {
                "name": "bo ning",
                "org": ""
            },
            {
                "name": "yongyong li",
                "org": ""
            }
        ],
        "venue": "Materials Transactions",
        "year": 2014
    },
    "x8GiY17e": {
        "id": "x8GiY17e",
        "title": "Effect of Quenching Process on the Microstructure and Hardness of High-Carbon Martensitic Stainless Steel",
        "abstract": "The microstructure and hardness of high-carbon martensitic stainless steel (HMSS) were investigated using thermal expansion analyzer, Thermo-calc, scanning electron microscope, x-ray diffraction, and Ultra-high temperature confocal microscope. The results indicate that the experimental steel should be austenitized in the temperature range of 1025-1075\u00a0\u00b0C, which can give a maximum hardness of 62 HRc with the microstructure consisting of martensite, retained austenite, and some undissolved carbides. With increasing austenitizing temperature, the amount of retained austenite increases, while the volume\u00a0fraction of carbides increases first and then decreases. The starting temperature and finish temperature of martensite formation decrease with increasing cooling rates. Air-quenched samples can obtain less retained austenite, more compact microstructure, and higher hardness, compared with that of oil-quenched samples. For HMSS, the martensitic transformation takes place at some isolated areas with a slow nucleation rate.",
        "keywords": [
            "austenitizing temperature",
            "cooling rate",
            "hardness",
            "high-carbon martensitic stainless steel",
            "microstructure"
        ],
        "authors": [
            {
                "name": "qintian zhu",
                "org": "university of science and technology beijing"
            },
            {
                "name": "jing li",
                "org": "university of science and technology beijing"
            },
            {
                "name": "chengbin shi",
                "org": "university of science and technology beijing"
            },
            {
                "name": "wentao yu",
                "org": "university of science and technology beijing"
            }
        ],
        "venue": "Journal of Materials Engineering and Performance",
        "year": 2015
    },
    "QGan1wJj": {
        "id": "QGan1wJj",
        "title": "Detection of crevasses over polar ice shelves using Satellite Laser Altimeter",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "yan liu",
                "org": "beijing normal university"
            },
            {
                "name": "xiao cheng",
                "org": "beijing normal university"
            },
            {
                "name": "fengming hui",
                "org": "beijing normal university"
            },
            {
                "name": "xianwei wang",
                "org": "beijing normal university"
            },
            {
                "name": "fang wang",
                "org": "beijing normal university"
            },
            {
                "name": "cheng cheng",
                "org": "beijing university of civil engineering and architecture"
            }
        ],
        "venue": "Science China-earth Sciences",
        "year": 2014
    },
    "ffTOpL2Q": {
        "id": "ffTOpL2Q",
        "title": "The Simulation Optimization and Experimental Improvement of the Refrigerator",
        "abstract": "",
        "keywords": [
            "velocity field"
        ],
        "authors": [
            {
                "name": "y l zhao",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "jia wen zhang",
                "org": ""
            },
            {
                "name": "ding ding yang",
                "org": ""
            },
            {
                "name": "tang li",
                "org": ""
            },
            {
                "name": "yan liu",
                "org": ""
            }
        ],
        "venue": "Advanced Materials Research",
        "year": 2014
    },
    "m8yO9AQN": {
        "id": "m8yO9AQN",
        "title": "Study on clinical efficacy of treating primary insomnia by wen dan ning xin grain",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "wei wang",
                "org": ""
            },
            {
                "name": "yan liu",
                "org": ""
            },
            {
                "name": "lin hong",
                "org": ""
            },
            {
                "name": "yumin lin",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "geng li",
                "org": ""
            }
        ],
        "venue": "Sleep Medicine",
        "year": 2013
    },
    "2PjbPnel": {
        "id": "2PjbPnel",
        "title": "MicroRNA-126 regulates EPCs function: Implications for a role of miR-126 in preeclampsia: MiR-126 Regulates EPCs Function",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "ting yan",
                "org": ""
            },
            {
                "name": "yan liu",
                "org": ""
            },
            {
                "name": "kai cui",
                "org": ""
            },
            {
                "name": "bin hu",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "li zou",
                "org": ""
            }
        ],
        "venue": "Journal of Cellular Biochemistry",
        "year": 2013
    },
    "4esmBUIv": {
        "id": "4esmBUIv",
        "title": "A Multi-Interface Ice and Snow Remote Monitoring Platform in the Polar Region",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "fengming hui",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "jialin zhang",
                "org": ""
            },
            {
                "name": "haijing zhang",
                "org": ""
            },
            {
                "name": "rongjin yang",
                "org": ""
            },
            {
                "name": "xiao cheng",
                "org": ""
            },
            {
                "name": "xiuhong li",
                "org": ""
            }
        ],
        "venue": "IEEE Sensors Journal",
        "year": 2014
    },
    "rq6bq0eW": {
        "id": "rq6bq0eW",
        "title": "Monitoring the Amery Ice Shelf front during 2004-2012 using ENVISAT ASAR data: Monitoring the Amery Ice Shelf front during 2004-2012 using ENVISAT ASAR data",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "mengxi zhai",
                "org": ""
            },
            {
                "name": "tiancheng zhao",
                "org": ""
            },
            {
                "name": "c i tianyu",
                "org": ""
            },
            {
                "name": "zhunzhun feng",
                "org": ""
            },
            {
                "name": "cheng cheng",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "xianwei wang",
                "org": ""
            },
            {
                "name": "yan liu",
                "org": ""
            },
            {
                "name": "jing kang",
                "org": ""
            },
            {
                "name": "fengming hui",
                "org": ""
            },
            {
                "name": "xiao cheng",
                "org": ""
            },
            {
                "name": "chen zhao",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "nFHpYSAh": {
        "id": "nFHpYSAh",
        "title": "The slow-growing tooth of the Amery Ice Shelf from 2004 to 2012",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "jing kang",
                "org": ""
            },
            {
                "name": "fengming hui",
                "org": ""
            },
            {
                "name": "yan liu",
                "org": ""
            },
            {
                "name": "xiao cheng",
                "org": ""
            },
            {
                "name": "chen zhao",
                "org": ""
            },
            {
                "name": "cheng cheng",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "xianwei wang",
                "org": ""
            }
        ],
        "venue": "Journal of Glaciology",
        "year": 2013
    },
    "Ev9xFVGr": {
        "id": "Ev9xFVGr",
        "title": "Mapping blue-ice areas in Antarctica using ETM+ and MODIS data",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "chen zhao",
                "org": ""
            },
            {
                "name": "zhenyu jin",
                "org": ""
            },
            {
                "name": "kun wang",
                "org": ""
            },
            {
                "name": "fang wang",
                "org": ""
            },
            {
                "name": "xianwei wang",
                "org": ""
            },
            {
                "name": "huabing huang",
                "org": ""
            },
            {
                "name": "fengming hui",
                "org": ""
            },
            {
                "name": "tianyu ci",
                "org": ""
            },
            {
                "name": "xiao cheng",
                "org": ""
            },
            {
                "name": "ted a scambos",
                "org": ""
            },
            {
                "name": "zhaohui chi",
                "org": ""
            },
            {
                "name": "yanmei zhang",
                "org": ""
            },
            {
                "name": "yan liu",
                "org": ""
            }
        ],
        "venue": "Annals of Glaciology",
        "year": 2014
    },
    "Q6nMgReH": {
        "id": "Q6nMgReH",
        "title": "Expression and Optimization of Reference Varieties for maize DUS testing in South China Subtropical Area",
        "abstract": "Based on the field experiment,the differences between the real expressions and the prescribed expressions in the maize DUS testing guideline from the 37 reference varieties were analyzed in Guangzhou DUS testing station in south China subtropical area.The results showed: among the 35 characteristics of the maize DUS testing guideline,the coefficient of coincidence(COC) of 29 characteristics was over 0.95,in which the COC of the characteristics of time of anthesis,tassel density of spikelets,number of tassel primary lateral branches and type of grain arrangement reached to 1.00.Six characteristics with the COC less than 0.95 were all the quantitative characteristics and farther analysis and optimization of the 14 expressing states of the 6 quantitative characteristics were carried out.",
        "keywords": [
            "maize",
            "DUS testing",
            "optimization",
            "reference varieties"
        ],
        "authors": [
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "RAO De-hua",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LI Chun-lan",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Agricultural Sciences",
        "year": 2012
    },
    "0tUw2j4d": {
        "id": "0tUw2j4d",
        "title": "The Optimal Screening of Reference Varieties for Characteristics of Visual Observation for Rice New Plant Variety DUS Testing",
        "abstract": "In order to screen stable and reliable reference varieties for rice new plant variety DUS testing,117 representative rice varieties of common knowledge from China,Japan and South Korea were used in the field testing experiment for 2 years observation continuously and the reference varieties for 106 expression statuses of 27 characteristics were screened systematically.The results showed that,the 16 varieties which were screened provided not only reference varieties for the characteristics represented by the original 23 reference varieties in the testing guideline,but also the reference varieties for several other characteristic expression statuses which had no reference varieties in the testing guideline.' Yuanzizhan ',' Tanzi ',' Hanlundao ',' Qijin ' and ' Wuzuinuo ' had comparatively strong ecological adaptability and priority should be given for the screening of rice reference varieties in other ecological area.The means of clustering statistical method was very useful for the screen of reference varieties of visual observation characteristics and might be considered as the method in the screen of reference varieties of visual observation characteristics for other plant species.",
        "keywords": [
            "reference variety",
            "screening",
            "rice",
            "DUS testing",
            "characteristic of visual observation"
        ],
        "authors": [
            {
                "name": "Xu Zhenjiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Liu Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Rao Dehua",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Li Chunlan",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Ren Yonghao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2012
    },
    "rEUIkeso": {
        "id": "rEUIkeso",
        "title": "Study on Test Guideline of Distinctness,Uniformity and Stability for Longan",
        "abstract": "The distinctness,uniformity and stability (DUS) test guideline was the reference and technical standards for the substantive examination.TGP/7 Development of Test Guidelines of International Union for the Protection of New Varieties of Plants (UPOV) was the basis for research of test guidelines.The DUS test guideline for longan strictly followed the basic principle of TGP/7,used the descriptors for Longan for reference,thus determined 45 characteristics,26 example varieties and assessment of DUS.The author gave very detail description of research principles,grading criteria of characteristics and selection of characteristics and example varieties,and also pointed out that the combination of DNA molecular markers and morphological test was direction of development of test guidelines.",
        "keywords": [
            "uniformity",
            "test guideline",
            "distinctness",
            "stability",
            "longan"
        ],
        "authors": [
            {
                "name": "Liu Hong",
                "org": " Guangzhou Division,New Plant Variety Test Center,MOA,Guangzhou ; College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Chen Dequan",
                "org": " Students'Affairs Department,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Ren Yonghao",
                "org": " Guangzhou Division,New Plant Variety Test Center,MOA,Guangzhou ; College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Xu Zhenjiang",
                "org": " Guangzhou Division,New Plant Variety Test Center,MOA,Guangzhou ; College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Rao Dehua",
                "org": " Guangzhou Division,New Plant Variety Test Center,MOA,Guangzhou ; College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Li Chunlan",
                "org": " Guangzhou Division,New Plant Variety Test Center,MOA,Guangzhou ; College of Agriculture,South China Agricultural University,Guangzhou "
            },
            {
                "name": "Ye Zixing",
                "org": " College of Horticulture,South China Agricultural University,Guangzhou "
            }
        ],
        "venue": "Chinese Agricultural Science Bulletin",
        "year": 2012
    },
    "HNIVIYsn": {
        "id": "HNIVIYsn",
        "title": "Strategy for protection and development of new plant varieties in Guangdong province",
        "abstract": "The current situation of the protection of new plant variety in Guangdong province was summarized in this paper.Aiming at the problems,such as the lack of awareness,less amount of the candidate varieties and difficulties in right protection,it is brought forward that in the future the protection of new plant variety should be strengthened;the awareness of the protection of new plant variety should be enhanced;the system of the governmental management should be bettered to improve the efficiency of the work of the protection of new plant variety;the DUS testing system should be established and consummated to provide the technique support to the protection of new plant variety.",
        "keywords": [
            "problems",
            "strategy",
            "the protection of new plant variety",
            "Guangdong"
        ],
        "authors": [
            {
                "name": "LIU Hong",
                "org": "College of Agronomy,South China Agriculture University/ Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agronomy,South China Agriculture University/ Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agronomy,South China Agriculture University/ Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "LI Chun-lan",
                "org": "College of Agronomy,South China Agriculture University/ Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "LI Zhi-lin",
                "org": "College of Agronomy,South China Agriculture University/ Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Agricultural Sciences",
        "year": 2006
    },
    "eyb2SK65": {
        "id": "eyb2SK65",
        "title": "Study on test guideline of distinctness,uniformity and stability for peanut",
        "abstract": "The distinctness,uniformity and stability(DUS) test guideline was the basis for the Plant Variety Protection(PVP).There were abundant resource and long cultivated history in our country.The preparation of DUS test guideline for peanut will have important significance for protecting peanut germplasm resources,promoting the development of breeding cause and increasing the status of international PVP fields for China.This paper gave very detail description of compilation principle and method for test guideline,selection and adoption of characteristics,selection of example varieties and assessment of DUS.",
        "keywords": [
            "uniformity",
            "test guideline",
            "peanut",
            "distinctness",
            "stability"
        ],
        "authors": [
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University/Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultural University/Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "RAO De-hua",
                "org": "College of Agriculture,South China Agricultural University/Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "LI Chun-lan",
                "org": "College of Agriculture,South China Agricultural University/Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultural University/Guangzhou Division,New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Agricultural Sciences",
        "year": 2012
    },
    "xKFY6NAA": {
        "id": "xKFY6NAA",
        "title": "Study on simplified cultivation techniques of intercropping and direct seeding of new wax wheat line Huanuo 1",
        "abstract": "Huanuo 1 was a new wax wheat line developed by south China agricultural university for 7 years.Based on the plot trial and field producing experiment,effects on the yield of wax wheat Huanuo 1 were studied by intercropping with rice and direct seeding after rice harvest.The results showed that as for the intercropping experiment of wax wheat Huanuo 1 with rice,the seed soaking for 24 hours before seeding was better than that without soaking and the optimum symbiotic period was 12 days before rice harvest or before the stage of one mature leaf and one new leaf of wax wheat,too longer symbiotic period was not good for wheat growth and would lead to reduced yield;under the experiment of direct seeding after rice harvest,the yield of 3 645 kg per hectare of wax wheat Huanuo 1 was produced over 0.51 hm2 field,which was more than two times of the yield using the farmer's wheat varieties under traditional cultivation way.",
        "keywords": [
            "direct seeding",
            "simplified cultivation",
            "intercropping",
            "wax wheat"
        ],
        "authors": [
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "ZHANG Lin",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Agricultural Sciences",
        "year": 2011
    },
    "g6oMCQU7": {
        "id": "g6oMCQU7",
        "title": "Effects of spraying zinc and other multiple nutrient elements on nutrient quality and yield of aromatic rice",
        "abstract": "Based on field experiment,the changes of the nutrient elements accumulation in milled grain and the yield of aromatic rice were studied by spraying zinc and other multiple nutrient elements and at the same time,the mechanism underlying the changes of grain yield was analyzed from the aspects of photosynthesis and carbohydrate accumulation.The results showed that the grain yield and the content of zinc and other nutrient elements in milled rice were significant improved by spraying zinc and other related nutrient elements on heading stage and followed on the 7th and 14th day after the heading stage.By spraying zinc and other multiple nutrient elements such as magnesium,kalium,iron,manganin,copper,cobalt,molybdenum and boron,the photosynthesis rate and chlorophyll content of flag leaf and the content of soluble sugar and starch in developing grain were obviously improved during the middle and late grain filling stage,which led to the improved filled grain percent,filled grains per panicle and 1000-grain weight and as a result the aromatic rice grain yield was significantly improved.",
        "keywords": [
            "zinc",
            "yield",
            "aromatic rice",
            "nutrient elements"
        ],
        "authors": [
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultrual University,Guangzhou ,China"
            },
            {
                "name": "XIAO Li-zhong",
                "org": "College of Agriculture,South China Agricultrual University,Guangzhou ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultrual University,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultrual University,Guangzhou ,China"
            },
            {
                "name": "LI Zhi-lin",
                "org": "College of Agriculture,South China Agricultrual University,Guangzhou ,China"
            }
        ],
        "venue": "Guangdong Agricultural Sciences",
        "year": 2012
    },
    "0VjULJG0": {
        "id": "0VjULJG0",
        "title": "Application of DUS Testing Technology in Agriculture Student Practice Teaching",
        "abstract": "The function of practice teaching in training the students in agriculture major.Considering the problems and shortcomings lying in agriculture practice teaching,the new plant variety DUS testing technology was applied into agriculture student practice teaching,and the exploration was made.So as to improve the practical ability of students.",
        "keywords": [
            "DUS testing",
            "agriculture major",
            "practice teaching",
            "new plant variety"
        ],
        "authors": [
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou Guangdong "
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou Guangdong "
            },
            {
                "name": "LI Chun-lan",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou Guangdong "
            },
            {
                "name": "RAO De-hua",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou Guangdong "
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou Guangdong "
            }
        ],
        "venue": "Modern Agricultural Science and Technology",
        "year": 2012
    },
    "6MsjiPLN": {
        "id": "6MsjiPLN",
        "title": "Effects of Nitrogen Application on Metabolism of Carbohydrate and Nitrogen in the Inferior Grains of Hybrid Rice with Large Panicle",
        "abstract": "Studies were conducted to investigale the effects of 3 different levels of nitrogen application(LN.90 kg / hm2;MN.180 kg / hm2;HN.270 kg / hm2) on metabolism of carbohydrate and nitrogen in the inferior grain of 2 two-line hybrid rice cultivars with large panicle,Peiza 67 and Peiza 88.The results showed that compared with the control(MN),higher nitrogen rates improved activity of glutamine synthetase and soluble-protein content,but decreased sucrose content,activity of sucrose synthase and starch accumulating amount in inferior grains,thus causing the inferior grain weight decreased.Lower nitrogen rates decreased sucrose content,activity of sucrose synthase and glutamine synthetase in inferior grains,thus causing the starch and soluble-protein accumulating amount reduced,which resulted in reducing the grain plumpness.Nitrogen application rate had little effect on the superior grains.",
        "keywords": [
            "nitrogen application rate",
            "metabolism of carbohydrate and nitrogen",
            "inferior grains",
            "two-line hybrid rice with large panicle"
        ],
        "authors": [
            {
                "name": "LIU Hong",
                "org": "Guangzhou Division of New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China;College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LI Zhi-lin",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "XU Zhen-jiang",
                "org": "Guangzhou Division of New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China;College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "WANG Wei",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "Guangzhou Division of New Plant Variety Test Center,Ministry of Agriculture,Guangzhou ,China;College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "XIAO Li-zhong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2013
    },
    "2F86WSiE": {
        "id": "2F86WSiE",
        "title": "Effects of Different Plant Density and Nitrogen Application Rate on Grain Yield and Quality of Waxy Wheat",
        "abstract": "The grain yield and quality of waxy wheat variety Huanuo 1 under different nitrogen application rate and plant density were studied.The results showed that the grain yield increased and the grain coarse protein content decreased significantly,with the number of basic seedlings increased from 1.2 million to 2.4 million per hm2.While with the number of basic seedlings increased from 2.4 million to 3.0 million per hm2,the grain yield increased with no obvious variation,the flour dough development time was shortened and the farinogram parameters value decreased obviously.The grain yield,the content of grain coarse protein and wet gluten and the farinogram parameters value increased simultaneously,with nitrogen application rate improved from 75 kg/hm2 to 225 kg/hm2.However,with nitrogen application rate increased to 300 kg/hm2,the grain yield and the farinogram parameters value reduced,the content of grain coarse protein and wet gluten improved slightly.Under this experimental condition,2.4 million basic seedlings per hm2 and 225 kg/hm2 nitrogen application rate were the optimal combination for obtaining higher grain yield and better quality of waxy wheat variety Huanuo 1.",
        "keywords": [
            "nitrogen application rate",
            "waxy wheat",
            "yield",
            "quality",
            "plant density"
        ],
        "authors": [
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "ZHANG Lin",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "XIE Hua-yun",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "HU Li-yong",
                "org": "College of Plant Science and Technology,Huazhong Agricultural University,Wuhan ,China"
            }
        ],
        "venue": "Journal of Huazhong Agricultural University",
        "year": 2010
    },
    "9B8XVOj7": {
        "id": "9B8XVOj7",
        "title": "Effect of Moderately High Temperature on Yield of Aromatic Rice and Its Mechanism during Grain Filling Stage",
        "abstract": "Yield and its mechamism under two temperatures during grain filling stage were studied by using one inbred aromatic rice variety and one hybrid aromatic rice combination.The results showed that,the filled grain rate and the filled grains per panicle of the two aromatic rice varieties under moderately high temperature(day mean temperature 30\u2103)were significantly reduced,although the 1000-grain weight was improved,resulting in the grain yield of Xinxiangzhan and Youzawushanxiang reduced by 22.8% and 29.9% respectively,compared to that under the regular temperature treatment.The chlorophyll content and the net photosynthetic rate in flag leaf of aromatic rice were significantly reduced,which resulted in insufficient \"source\" for the formation of yield.Meanwhile,the soluble sugar content and the starch accumulation rate in the developing grains decreased,which made the \"sink\" significantly weak.",
        "keywords": [
            "Yield",
            "Temperature",
            "Aromatic rice",
            "Physiological mechanism"
        ],
        "authors": [
            {
                "name": "Xu Zhenjiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "Xiao Lizhong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "Liu Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "Ren Yonghao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "Li Zhilin",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            }
        ],
        "venue": "Crops",
        "year": 2012
    },
    "etvoTbNk": {
        "id": "etvoTbNk",
        "title": "Difference Analysis and Application in DUS Testing of Grain Quality Characteristics of Rice New Varieties for DUS Testing",
        "abstract": "Based on the DUS testing experiment,the difference of eight main grain quality characteristics of 23 rice applicant varieties and their similar ones were statistically analyzed in 2 continuous years.A significant difference was found among varieties on each of the eight grain quality characteristics,and the variation coefficients of these grain quality characteristics were ranked in the order of chalky percent,chalkiness,alkali value,amylose content,gel consistency,head rice,milled rice and brown rice.The variation coefficient of head rice,chalky percent,chalkiness and amylose content of conventional rice varieties were obviously higher than those of hybrid ones.Significant differences were found on at least 3 of the eight grain quality characteristics for each of the 4 pairs of rice DUS testing varieties with difference on only 1-2 characteristics according to the DUS testing results.All the eight grain quality characteristics in this experiment met the UPOV requirements as DUS testing characteristics and could be listed as the complimentary characteristics in the rice DUS testing guideline.",
        "keywords": [
            "rice",
            "dus testing",
            "quality characteristic",
            "new plant variety",
            "testing",
            "stability",
            "cultivars"
        ],
        "authors": [
            {
                "name": "XU Zhenjiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "RAO Dehua",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LI Chunlan",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "REN Yonghao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of South China Agricultural University",
        "year": 2013
    },
    "1k1oBsiG": {
        "id": "1k1oBsiG",
        "title": "Progress on Ghrelin and Its Application Prospect in Animal Husbandry",
        "abstract": "Ghrelin is a endogenic ligand of growth hormone secretagogue receptor(GHS-R),which is made up of 28 amino acid residues.Ghrelin is secreted by various tissues of body,mainly by gastric tissues.Ghrelin regulates GH release from pituitary,participates in the regulation of energy metabolism,increases feed intake and influences the cardiovascular function and the release of other hormones.In this paper,a simple review is given on the chemical structure and physiological functions of ghrelin and prospective application in animal husbandry.",
        "keywords": [
            "ghrelin",
            "endocrine",
            "growth-hormone"
        ],
        "authors": [
            {
                "name": "LI Jia-kui",
                "org": "College of Veterinary Medicine,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Veterinary Medicine,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "GUO Rui",
                "org": "College of Veterinary Medicine,Huazhong Agricultural University,Wuhan ,China"
            },
            {
                "name": "ZHANG Yan-hong",
                "org": "College of Veterinary Medicine,Huazhong Agricultural University,Wuhan ,China"
            }
        ],
        "venue": "Hubei Agricultural Sciences",
        "year": 2006
    },
    "emNKO1fC": {
        "id": "emNKO1fC",
        "title": "Stability and Importance of Morphological Characteristics in Example Varieties Based on DUS Test",
        "abstract": "In order to further improve the accuracy of distinctness,uniformity and stability(ab.DUS) test of rice varieties,the AMMI model was used to analyse the stability and Random Forest algorithm was used to evaluate the importance for 50 characteristics of 49 rice example varieties listed in DUS test guideline.The results showed that stability is largely different among different characteristics,and visual characteristics are highly stable for main qualitative characteristics and pseudo-qualitative characteristics,and measurement characteristics had low stability for quantitative characteristics.On the whole,the importance parameter difference was very big among different characteristics,which is larger for measurement characteristics,and relatively smaller for visual characteristics.Some characteristics with low stability and low importance could be excluded from DUS guideline,for example \"panicle:exsertion\",\"panicle:type\",\"panicle:attitude\",\"Spikelet:pubescence of lemma\",\"leaf:pubescence\",while those with low stability,but very important in practice,for example \"time of maturity\" and \"time of heading\" could be only in the location of applicants tested to avoid misjustice and use example varieties for correction.",
        "keywords": [
            "rice",
            "measurement observation",
            "dus test",
            "importance",
            "stability",
            "visual observation"
        ],
        "authors": [
            {
                "name": "TANG Hao",
                "org": " 1 Hunan Agricultural University,Changsha ,China; Development Center for Science & Technology of Ministry of Agriculture,Beijing ,China"
            },
            {
                "name": "LIU Hong",
                "org": " South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "YU Han-Yong",
                "org": " China National Rice Research Institute,Hangzhou ,China"
            },
            {
                "name": "ZHANG Zhe-Feng",
                "org": " Sichuan Academy of Agricultural Sciences,Chengdu ,China"
            },
            {
                "name": "XIAO Ying-Hui",
                "org": " 1 Hunan Agricultural University,Changsha ,China"
            },
            {
                "name": "YANG Yi-Shan",
                "org": " Hunan Hybrid Rice Research Center,Changsha ,China"
            },
            {
                "name": "CHEN Li-Yun",
                "org": " 1 Hunan Agricultural University,Changsha ,China"
            }
        ],
        "venue": "Acta Agronomica Sinica",
        "year": 2013
    },
    "TKdowMEe": {
        "id": "TKdowMEe",
        "title": "Study on the Statistical Assessment of Distinctness of Quantitative Characteristics in DUS Testing of the New Rice Varieties",
        "abstract": "Ten main quantitative characteristics of 3 candidate varieties and their similar ones were statistically analysed in 2 continuous years.If the quantitative characteristic of the candidate variety and its similar one is too close,there may actually be no distinctness on the quantitative characteristic,while the classifications of the characteristic of the two varieties are different in DUS test guideline.However,if the difference of the average value of the quantitative characteristic between the candidate variety and its similar one is comparatively big,there may be significant distinctness on the quantitative characteristic,while the classifications of the quantitative characteristics of the two varieties are the same in DUS test guideline.Besides the criteria of DUS test guideline,statistical analysis should be an important method to assess the distinctness of the quantitative characteristics of new rice varieties.",
        "keywords": [
            "quantitative characteristics",
            "new rice varieties",
            "DUS testing",
            "distinctness",
            "assessment"
        ],
        "authors": [
            {
                "name": "XU Zhen-jiang",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LIU Hong",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LI Chun-lan",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "LI Zhi-lin",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            },
            {
                "name": "REN Yong-hao",
                "org": "College of Agriculture,South China Agricultural University,Guangzhou ,China"
            }
        ],
        "venue": "Journal of South China Agricultural University",
        "year": 2008
    },
    "VOWmupFw": {
        "authors": [
            {
                "name": "R. Liu",
                "org": "Department of Chemistry"
            },
            {
                "name": "C. Gao",
                "org": "Lanzhou Inst. of Chemical Physics"
            },
            {
                "name": "S. Hua",
                "org": "Dept. of Environmental Engineering"
            },
            {
                "name": "Y. Feng",
                "org": "Hebei Geological University"
            },
            {
                "name": "J. Yang",
                "org": "Department of Chemistry"
            }
        ],
        "title": "Rapid spectrometric determination of Ni(II) in electroless nickel deposition baths containing iron",
        "abstract": "The influence of complexant, temperature, Fe(III), Fe(II), pH, NaH ",
        "keywords": [
            ""
        ],
        "venue": "Plating and Surface Finishing",
        "year": 2001,
        "id": "VOWmupFw"
    },
    "Qa3NIqho": {
        "authors": [
            {
                "name": "Xing Liu",
                "org": "School of Aeronautics and Astronautics"
            },
            {
                "name": "Jian Deng",
                "org": "School of Aeronautics and Astronautics"
            },
            {
                "name": "Yao Zheng",
                "org": "School of Aeronautics and Astronautics"
            },
            {
                "name": "Guo-Feng Pan",
                "org": "School of Aeronautics and Astronautics"
            }
        ],
        "title": "Impact of aerodynamics of pantograph of a high-speed train on pantograph-catenary current collection",
        "abstract": "For the analysis of high-speed train pantograph-catenary current collection quality considering the impact of pantograph average steady-state and unsteady aerodynamic forces, based on the pantograph model with unsteady aerodynamics and the assumption of uniform flow, the unsteady drag and lift forces of pantograph components were obtained by computational fluid dynamics (CFD) method. By loading the pantograph unsteady aerodynamic forces with the pulsation and the mean steady aerodynamic forces, which were the time average of the unsteady aerodynamic forces, to the dynamic model of pantograph-catenary system respectively, the dynamic features of pantograph-catenary system under two kinds of aerodynamic forces were compared. The simulation shows that under the pantograph three mass model, the dynamic responses enduring uniform current with either pantograph steady or unsteady flow dynamic assumption exhibit little divergence. Moreover, the effects of the amplitude and frequency of the pantograph unsteady aerodynamic force incentives were also examined. The resuts indicate that when the amplitude of the incentive is large or the frequency approaches to the natural frequency of the system, the current collection characteristics would be influenced significantly. This study will provide a basic foundation for the further investigations on the current collection quality of pantograph-catenary system under different complicated aerodynamic conditions such as under non-uniform flows, or cross winds.",
        "keywords": [
            "CFD",
            "High-speed train",
            "Pantograph-catenary dynamics",
            "Unsteady aerodynamics"
        ],
        "venue": "Zhejiang Daxue Xuebao (Gongxue Ban)/Journal of Zhejiang University (Engineering Science)",
        "year": 2013,
        "id": "Qa3NIqho"
    },
    "8dCc5yPS": {
        "authors": [
            {
                "name": "Shu-Qing Yang",
                "org": "Tangshan Vocational Technical College"
            },
            {
                "name": "Zhi-Qiang Wang",
                "org": "Department of Trauma"
            },
            {
                "name": "Zhi-Gang Zhang",
                "org": "Department of Joint"
            },
            {
                "name": "Li-Feng Zhang",
                "org": "Department of Trauma"
            },
            {
                "name": "Ji Li",
                "org": "Department of Trauma"
            }
        ],
        "title": "Bone morphogenetic protein-2 in bone reconstruction",
        "abstract": "Objective: To retrospectively analyze the recent internal developments of research on bone morphogenetic protein-2 in the application of bone reconstruction. Data sources: English literatures related to bone morphogenetic protein-2 from January 1999 to June 2005 were retrieved on Medline by computer and the key words were \"bone morphogenetic protein-2, bone tissue engineering and gene therapy\". Meanwhile, Chinese literatures about bone morphogenetic protein-2 from January 1999 to June 2005 were searched in CNKI Chinese database with the key words of \"bone morphogenetic protein-2, bone tissue engineering and gene therapy\". Study selection: Data were selected in primary trial, articles contained studying objectives were enrolled and those related to studying objectives were screened. Accepting criteria: 1 Bone reconstruction and the bone tissue engineering, 2 Bone morphogenetic protein-2. Excluded cnteria: 1 Repeated studies and reviews, 2 Meta analytic studies. Data extraction: Totally 67 Chinese literatures, 55 English articles and nearly 100 abstracts were collected, among which 15 ones were in accordance with the inclusive criteria. Excluded literatures were mostly repeated studies or studies beyond bone tissue engineering. Data Synthesis: Bone morphogenetic protein-2 could induce mesenchymal cells to differentiate into osteoblast and chondroblast and had a powerful effect of ectopic osteogenesis. Bone morphogenetic protein-2 released from carrier or gene could repair bone defect effectively. Researches of gene therapy on bone morphogenetic protein-2 provided new ways for bone defect reconstruction. Conclusion: It is feasible to repair bone defect with bone morphogenetic protein-2. However, methods need further researching.",
        "keywords": [
            ""
        ],
        "venue": "Chinese Journal of Clinical Rehabilitation",
        "year": 2006,
        "id": "8dCc5yPS"
    },
    "QBX4M7MD": {
        "authors": [
            {
                "name": "Feng Zhu",
                "org": "State Key Laboratory of Mechanics and Control of Mechanical Structures, College of Aerospace Engineering, Nanjing University of Aeronautic and Astronautic"
            },
            {
                "name": "Bin Wang",
                "org": "State Key Laboratory of Mechanics and Control of Mechanical Structures, College of Aerospace Engineering, Nanjing University of Aeronautic and Astronautic"
            },
            {
                "name": "Zheng-Hua Qian",
                "org": "State Key Laboratory of Mechanics and Control of Mechanical Structures, College of Aerospace Engineering, Nanjing University of Aeronautic and Astronautic"
            }
        ],
        "title": "Wave propagation in piezoelectric layered structure of film bulk acoustic resonator",
        "abstract": "In this paper, we consider the sandwich structure composed of silicon substrate, piezoelectric layer and electrode layers in the typical structure of FBAR. We assume a special solution in the form of harmonic wave in the piezoelectric layer, and substitute it into the simplified stress equations of motion and the charge equation of electrostatic. A correction to the solution assumed is obtained in order to satisfy these equations. Similarly, a correctional solution assumed in the form of harmonic wave in the silicon substrate can be obtained. We can substitute these correctional solutions into continuity conditions and boundary conditions. The relations of wave number and frequency are obtained. The dispersion curves are calculated from the relation. The frequencies when wave number is zero, the influence of the mass ratio of piezoelectric layer and electrode plate, and the vibration images are discussed further.",
        "keywords": [
            "Dispersion curve",
            "FBARs",
            "Piezoelectric layered structure"
        ],
        "venue": "Proceedings of the 2014 Symposium on Piezoelectricity, Acoustic Waves and Device Applications, SPAWDA 2014",
        "year": 2014,
        "id": "QBX4M7MD"
    },
    "jNx5WtGR": {
        "authors": [
            {
                "name": "Ren-Qiang Yang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Xiao-Shu Cheng",
                "org": "Department of Cardiology"
            },
            {
                "name": "Chen Liu",
                "org": "Department of Cardiology"
            },
            {
                "name": "Ling Wang",
                "org": "Department of Cardiology"
            },
            {
                "name": "Ping Li",
                "org": "Department of Cardiology"
            },
            {
                "name": "Yan-Qing Wu",
                "org": "Department of Cardiology"
            },
            {
                "name": "Qing-Hua Wu",
                "org": "Department of Cardiology"
            },
            {
                "name": "Hai Su",
                "org": "Department of Cardiology"
            },
            {
                "name": "Yu-Cheng Dai",
                "org": "Department of Cardiology"
            }
        ],
        "title": "The protection of Heme oxygenase-1 from acute cardiocyte injury in rats",
        "abstract": "Objective: To observe the protection of Heme oxygenase-1 (HO-1) from lipopolysacharide (LPS)-induced cardiocyte injury and its mechanism. Methods: Cardiocyte was isolated from SD neonate rat and cultured in vitro, and was divided into control group (normal culture), LPS group (with stimulation of 30 \u03bcmoL/L LPS for 1 hour), LPS + Hemin group(with same treatment to LPS group after stimulation of 5 \u03bcmoL/L Hemin for 1 hour),and LPS + ZnPP group (with same treatment to LPS group after stimulation of 3 \u03bcmoL/L ZnPP for 1 hour). The level of lactic-dehydrogenase(LDH), malondialdehyde (MDA), superoxide dismutase (SOD) were measured by thio-barbituric acid and xanthine oxidase techniques. The cell heart rhythm, survival rate and apoptosis rate were examined. The expressions of nuclear factor \u03baB (NF-\u03baB), HO-1 and tumor necrosis factor-alpha (TNF-\u03b1) were measured with Western blotting. The HO-1 mRNA was examined by RT-PCR. Results: The level of LDH and MDA in LPS, LPS + Hemin, and LPS + ZnPP groups were (113 \u00b1 15), (79 \u00b1 13), (154 \u00b1 22) U/L, and(1.88 \u00b1 0.36),(1.16 \u00b1 0.32),(2.84 \u00b1 0.44) mmoL/L respectively, which were all obviously higher than those in control group (69 \u00b1 10) U/L, (0.87 \u00b1 0.25) mmol/L, P <0.05]. The level of SOD in LPS, PS + Hemin, and LPS + ZnPP groups (17.8 \u00b1 1.8 22.5 \u00b1 2.4, 13.4 \u00b1 1.5 U/mL, respectively) was all obviously lower than that in control group (24.3 \u00b1 3.6 U/ mL, P <0.05). The apoptosis rate and heart rhythm were obviously higher and survival rate significantly lower in LPS, LPS + Hemin, and LPS + ZnPP groups than those in control group(P < 0.05). The level of HO-1mRNA in LPS, LPS + Hemin, and LPS \u00b1 ZnPP groups was higher than that in control group(P <0.01), among which LPS + Hemin group was the highest. The level of HO-1, TNF-\u03b1 and NF-\u03baB in LPS, LPS + Hemin, and LPS + ZnPP groups was higher than those in control group(P <0.05), among which the level of HO-1 protein in LPS + Hemin group was the highest, the level of TNF-\u03b1 and NF-\u03baB in LPS + ZnPP group was highest. Conclusion: LPS can induce cardiocyte injury,which can be inhibited through the anti-inflammatory, anti-oxidant, and anti-apoptosis functions by HO-1.",
        "keywords": [
            "Heme oxygenase(decyclizing)",
            "Lipopolysaccharides",
            "Myocytes, cardiac",
            "Tumor necrosis factor-alpha"
        ],
        "venue": "Chinese Journal of Burns",
        "year": 2008,
        "id": "jNx5WtGR"
    },
    "rxe7ffmT": {
        "authors": [
            {
                "name": "T.-L. Wen",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "D. Wang",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "H.Y. Tu",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "M. Chen",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "Z. Lu",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "Z. Zhang",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "H. Nie",
                "org": "Shanghai Institute of Ceramics"
            },
            {
                "name": "W. Huang",
                "org": "Shanghai Institute of Ceramics"
            }
        ],
        "title": "Research on planar SOFC stack",
        "keywords": [
            "Planar SOFC performance",
            "SOFC stack",
            "Solid oxide fuel cell"
        ],
        "venue": "Solid State Ionics",
        "year": 2002,
        "id": "rxe7ffmT"
    },
    "y28Znl8z": {
        "authors": [
            {
                "name": "T.-L. Wen",
                "org": ""
            },
            {
                "name": "D. Wang",
                "org": ""
            },
            {
                "name": "M. Chen",
                "org": ""
            },
            {
                "name": "H. Tu",
                "org": ""
            },
            {
                "name": "Z. Lu",
                "org": ""
            },
            {
                "name": "Z. Zhang",
                "org": ""
            },
            {
                "name": "H. Nie",
                "org": ""
            },
            {
                "name": "W. Huang",
                "org": ""
            }
        ],
        "title": "Material research for planar SOFC stack",
        "keywords": [
            "Materials for SOFC stack",
            "Planar SOFC",
            "Solid oxide fuel cell"
        ],
        "venue": "Solid State Ionics",
        "year": 2002,
        "id": "y28Znl8z"
    },
    "1vxU1LfX": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jing Zuo",
                "org": "Department of Internal Oncology"
            },
            {
                "name": "Jin-Ya Li",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jian-Wen Guo",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Lian-Fu Zuo",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jing Wang",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jiang-Hui Liu",
                "org": "Department of FCM Analysis"
            }
        ],
        "title": "Role of artesunate in resistance-reversal of esophageal cancer Eca109/ADM cells to doxorubicin",
        "abstract": "Objective:To explore the role of artesunate (Art) in resistance-reversal of Eca109/ADM cells and the related mechanism. Methods:The present study was divided into 4 groups: normal saline (NS) control group, Art (0.1 \u03bcmol/L) group, ADM (0.2 \u03bcg/ml) group, and Art (0.1 \u03bcmol/L)+ADM (0.2 \u03bcg/ml) group. The apoptosis rate, ADM content and ABCG2 (ATP-binding cassette transporter G2) protein expression in Eca109/ADM cells were detected by flow cytometry 48 h after treated with Art, ADM, and Art+ADM. ABCG2 protein expression in Eca109/ADM cells was further examined by Western blotting analysis. Results:The apoptosis rate of Eca109/ADM cells in Art+ADM group was (12.89\u00b10.87)%, being significantly higher than that in the Art group (1.58\u00b10.12)%, ADM group (6.55\u00b10.90)% and NS group (1.44\u00b10.10)% (P<0.05). Art increased the sensitivity of Eca109/ADM cells to ADM. Flow cytometry results showed that the ABCG2 protein expression in Eca109/ADM cells of Art+ADM group (644.60\u00b13.21) was significantly lower than that in ADM group (659.15\u00b14.59) and NS group (658.14\u00b16.88) (P<0.05), but was similar to that in Art group (644.31\u00b13.96) (P>0.05). Western blotting analysis results were consistent with those detected by flow cytometry. The ABCG2 protein expression of Eca109/ADM cells in Art group (0.70\u00b10.02) was significantly decreased compared with NS group (0.80\u00b10.03) (P<0.05), and that in Art+ADM group (0.71\u00b10.04) was also decreased compared with ADM group (0.81\u00b10.05) (P<0.05). The ADM content of Eca109/ADM cells in Art+ADM group was significantly higher than those in Art, ADM and NS groups (848.02\u00b15.04 vs 763.29\u00b14.02, 800.25\u00b13.84, 763.88\u00b12.03; P<0.01). Conclusion: Art can decrease ABCG2 protein expression and increase ADM content in Eca109/ADM cells, and it can also reverse the drug resistance of Eca109/ADM cells.",
        "keywords": [
            "Artesunate",
            "ATP-binding cassette transporter G2 (ABCG2)",
            "Doxorubicin",
            "Resistance-reversal"
        ],
        "venue": "Chinese Journal of Cancer Biotherapy",
        "year": 2011,
        "id": "1vxU1LfX"
    },
    "f2gGOWSN": {
        "authors": [
            {
                "name": "Jing Zuo",
                "org": "Department of Medical Oncology"
            },
            {
                "name": "Liang Liu",
                "org": "Section of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Min Zhao",
                "org": "Section of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Lianfu Zuo",
                "org": "Section of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            }
        ],
        "title": "SRF expression and its biological significance in gastric carcinoma cells",
        "abstract": "Objective: This study aims to explore the relationship between serum response factor SRF expression level and gastrio cancer progression by detecting SRF expression level in cancer cells. Methods: The SRF gene in SGC-7901 cells was silenced by RNA interference. Transfection efficiency was detected by fluorescence microscopy, cell proliferation by CCK 8 method, SRF gene and protein expression level by real-time polymerase chain reaction and Western blot, and cell cycle by flow cytometry. Results: Cell treatment with siRNA-SRF induced significant reduction in SRF mRNA levels. Western blot analysis showed that SRF protein decreased by 40.1% in the siRNA group compared with that in the control group (P<0.05). Compared with the blank, negative, and mock transfection control groups, cell proliferation of the siRNA-SRF group decreased. The inhibition ratio reached 64.24%, as measured by the CCK-8 assay (P<0.05). Treatment with siRNA could block SGC-7901 cell cycle at Go/Gi phase (P<0.05). Conclusion: SRF expression is closely associated with gastric carcinoma cell proliferation. SRF protein level detection can provide a certain reference value in evaluating malignant gastric carcinoma progression. SRF is possibly an important target for the prevention and control of gastric cancers.",
        "keywords": [
            "Flow cytometry",
            "Gastric carcinoma",
            "Serum response factor"
        ],
        "venue": "Chinese Journal of Clinical Oncology",
        "year": 2014,
        "id": "f2gGOWSN"
    },
    "iJyHSxY1": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": "Department of Flow Cytometry Analysis"
            },
            {
                "name": "Lian Fu Zuo",
                "org": "Department of Flow Cytometry Analysis"
            },
            {
                "name": "Jian Wen Guo",
                "org": "Department of Flow Cytometry Analysis"
            }
        ],
        "title": "Reversal of multidrug resistance by the anti-malaria drug artesunate in the esophageal cancer Eca109/ABCG2 cell line",
        "abstract": "The overexpression of ATP-binding cassette (ABC) transporters confers multidrug resistance (MDR) to tumor cells. ABCG2 is a member of the ABC superfamily. The present study aimed to investigate the correlation between ABCG2 expression and the MDR of esophageal cancer and to estimate the therapeutic benefit of downregulating ABCG2 expression and reversing chemoresistance in esophageal cells using artesunate (Art). The Eca109/ABCG2 cell line was established by transfecting the ABCG2 gene into Eca109 cells. The Eca109/ABCG2 esophageal cancer cells with ABCG2 gene overexpression were resistant to adriamycin (ADM), daunorubicin (DNR) and mitoxantrone (MIT), which indicated that ABCG2 may be associated with drug resistance in esophageal cancer. Art is a noteworthy antimalarial agent, particularly in severe and drug-resistant cancer cases, as Art is able to reverse drug resistance. In the present study, Art also exerted profound anticancer activity. The mechanism for the reversal of multidrug resistance by Art in esophageal carcinoma was analyzed using cellular experiments, but still remains largely unknown.",
        "keywords": [
            "Chemotherapy",
            "Esophageal cancer",
            "Multidrug resistance"
        ],
        "venue": "Oncology Letters",
        "year": 2013,
        "id": "iJyHSxY1"
    },
    "SVfI7hPy": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": "Laboratory of FCM Analysis, Tumor Institute, HeBei Medical University-Affiliated Fourth Hospital"
            },
            {
                "name": "Hui Li",
                "org": "Laboratory of FCM Analysis, Tumor Institute, HeBei Medical University-Affiliated Fourth Hospital"
            },
            {
                "name": "Lianfu Zuo",
                "org": "Laboratory of FCM Analysis, Tumor Institute, HeBei Medical University-Affiliated Fourth Hospital"
            }
        ],
        "title": "Survivin- and caspase-dependent apoptosis of esophageal cancer Ec9706 cells after norcantharidin exposure ",
        "abstract": "Objective: To study the effect of norcantharidin on apoptosis of esophageal cancer Ec9706 cells and the putative mechanism(s) underlying the effect. Methods: Ec9706 cells were treated with norcantharidin at 0, 5, 10, 20 or 40 \u03bcg/ml. Cell viability was detemiined by MTT assays and apoptosis, caspase-3 and survivin protein levels in the treated Ec9706 cells were assessed by flow cytometry, respectively, at 12, 24 and 48 h after treatment. Results: N orcantharidin inhibited the growth of Ec9706 cells in a dose- and time-dependent manner; the growth inhibition rate was (80. 00 \u00b1 2.15)% at 40 \u03bcg/ml for 48 h. Norcantharidin induced apoptosis, significantly increased caspase-3 protein level (P < 0. 05) and significantly decreased survivin protein level (P < 0. 05) in Ec9706 cells in a dose- and time-dependent manner ; the apoptosis rate was 38. 57 \u00b1 1. 76% at 20 \u03bcg/ml for 48h. Conclusion: Norcantharidin may induce apoptosis of esophageal cancer Ec9706 cells through downregulation of survivin expression and upregulation of caspase-3 expression.",
        "keywords": [
            "Cell apoptosis",
            "Ec9706 cell",
            "Esophageal squamous cell carcinoma",
            "Norcantharidin"
        ],
        "venue": "Chinese Journal of Cancer Biotherapy",
        "year": 2014,
        "id": "SVfI7hPy"
    },
    "2bXtDGLA": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": "Department of Flow Cytometry Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Lian Fu Zuo",
                "org": "Department of Flow Cytometry Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Jian Wen Guo",
                "org": "Department of Flow Cytometry Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            }
        ],
        "title": "ABCG2 gene amplification and expression in esophageal cancer cells with acquired adriamycin resistance",
        "abstract": "Resistance to chemotherapeutic agents is the main reason for treatment failure in patients with cancer. The primary mechanism of multidrug resistance (MDR) is the overexpression of drug efflux transporters, including ATP-binding cassette transporter G2 (ABCG2). To the best of our knowledge, the MDR mechanisms of esophageal cancer have not been described. An adriamycin (ADM)-resistant subline, Eca109/ADM, was generated from the Eca109 esophageal cancer cell line by a stepwise selection in ADM from 0.002 to 0.02 ng/\u03bcl. The resulting subline, designated Eca109/ADM, revealed a 3.29-fold resistance against ADM compared with the Eca109 cell line. The ABCG2 gene expression in the Eca109/ADM cells was increased compared with that of the Eca109 cells. The cellular properties of the Eca109/ADM cells were detected by reverse transcription polymerase chain reaction (RT-PCR), flow cytometry and western blotting. The ABCG2 expression levels were detected by RT-PCR and flow cytometry, and the drug efflux effect was detected by flow cytometry. The present study detected the correlation between ABCG2 and the multidrug resistance of esophageal cancer. ABCG2 gene expression and the drug efflux effect of the Eca109/ADM cells were increased compared with those of the Eca109 cells. Collectively, the results of this study indicated that the overexpression of ABCG2 in the Eca109/ADM cells resulted in drug efflux, which may be responsible for the development of esophageal cancer MDR.",
        "keywords": [
            "ABCG2",
            "ATP-binding cassette transporter",
            "Esophageal cancer",
            "Multidrug resistance"
        ],
        "venue": "Molecular Medicine Reports",
        "year": 2014,
        "id": "2bXtDGLA"
    },
    "CRYBDh11": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": "Department of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Lian-Fu Zuo",
                "org": "Department of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Jing Zuo",
                "org": "Department of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            },
            {
                "name": "Jing Wang",
                "org": "Department of FCM Analysis, Tumor Institute, Fourth Hospital of Hebei Medical University"
            }
        ],
        "title": "Artesunate induces apoptosis and inhibits growth of Eca109 and Ec9706 human esophageal cancer cell lines in vitro and in vivo",
        "abstract": "Esophageal cancer is a common malignant tumor worldwide with a high incidence rate in China and it is a great threat to human health. Combined modality therapy is used for chemotherapeutic treatment of esophageal cancer; however, drug resistance and side effects of the drugs is a major barrier to the success of chemotherapy. As chemotherapy with common drugs is far from providing satisfactory clinical outcomes for patients with esophageal cancer, more efficient drugs are urgently required. Artesunate (Art) is the first-line treatment option for malaria; however, it was recently revealed that Art has remarkable anti-tumor activity, making it a novel candidate for cancer chemotherapy. Although the anti-cancer effects of Art have been well documented, its potential against esophageal cancer has rarely been explored. The present study aimed to investigate the significance and mechanism of the anti-proliferative activity of Art on esophageal cancer cells in vitro and in vivo. In the in vitro experiments, Art inhibited the growth as well as induced cell apoptosis and cell cycle arrest of esophageal cancer cell lines (Eca109 and Ec9706) in a concentration-dependent manner. Furthermore, downregulation of mitochondrial membrane potential, B-cell lymphoma-2 (BCL-2) and CDC25A, as well as upregulation of BCL-2-associated X protein (Bax) and caspase-3 expression in Art-treated cells were identified. In addition, an in vivo study showed that Art produced a dose-dependent tumor regression in nude mice, while side effects were low. The anti-tumor activity of 200 mg/kg Art was similar to that of 3 mg/kg cisplatin. In conclusion, Art exerted concentration-dependent inhibitory activity against esophageal cancer in vivo and in vitro by inducing cell apoptosis and cell cycle arrest through affecting mitochondrial membrane potential, BCL-2, Bax, caspase-3 and CDC25A.",
        "keywords": [
            "Artesunate",
            "Cell division cycle 25 A",
            "Esophageal carcinoma",
            "Flow cytometry",
            "Mitochondrial membrane potential"
        ],
        "venue": "Molecular Medicine Reports",
        "year": 2015,
        "id": "CRYBDh11"
    },
    "3xRuZOgX": {
        "authors": [
            {
                "name": "Jiang-Hui Liu",
                "org": "Division of Analytical Cycology"
            },
            {
                "name": "Jin-Mei Li",
                "org": "Division of Analytical Cycology"
            },
            {
                "name": "Lian-Fu Zuo",
                "org": "Division of Analytical Cycology"
            },
            {
                "name": "Jian-Wei Guo",
                "org": "Division of Analytical Cycology"
            },
            {
                "name": "Liang Liu",
                "org": "Division of Analytical Cycology"
            },
            {
                "name": "Jing Wang",
                "org": "Division of Analytical Cycology"
            }
        ],
        "title": "Expressions of PPAR\u03b3 and MMP-7 in esophageal squamous cell carcinoma and their significance",
        "abstract": "Objective: To investigate the expressions and biological significance of PPAR\u03b3 and MMP-7 in esophageal squamous carcinoma tissnes. Methods: The expressions of PPAR\u03b3 and MMP-7 were examined by SP immunohistochemical stain (IHC) in 40 cases of esophageal carcinoma specimens, 25 cases of dysplasia and 13 cases of normal tissues. Moreover, they were examined in 30 cases of esophageal carcinoma specimens, 15 cases of dysptasia and 10 cases of normal tissues by FCM. Results: The positive expression rate of PPAR\u03b3 in esophageal carcinoma (52.5%,21/40) was significantly higher than that in dysplasia (20.0%,5/25) and normal tissues (7.7%,1/13), P<0.05, and high expression of PPAR\u03b3 was correlated with the tumor differentiation and metastasis of esophageal squamous cell carcinoma, P<0.05. The positive expression of MMP-7 in esophageal carcinoma (65.0%,26/40) was significantly higher than that in dysplasia (28.0%,7/25) and normal tissues (0),P<0.05, and high expression of MMP-7 was correlated with the invasion and metastasis of esophageal squamous cell carcinoma, P<0.05. There was a negative correlation between MMP-7 and PPAR\u03b3. Conclusion: PPAR\u03b3 and MMP-7 can be involved in carcinogenesis and progression of esophageal squamous cell carcinoma.",
        "keywords": [
            "Carcinoma",
            "Esophageal neoplasms",
            "Matrilysin",
            "Peroxisome preliferator-activated receptors",
            "Squamous cell"
        ],
        "venue": "Chinese Journal of Cancer Prevention and Treatment",
        "year": 2009,
        "id": "3xRuZOgX"
    },
    "TTQKywlI": {
        "authors": [
            {
                "name": "Jing Zuo",
                "org": "Department of Oncology"
            },
            {
                "name": "Da-Hu Wang",
                "org": "Department of Dermatology"
            },
            {
                "name": "Yu-Jun Zhang",
                "org": "Department of Pathology"
            },
            {
                "name": "Liang Liu",
                "org": "Hebei Cancer Institute"
            },
            {
                "name": "Feng-Ling Liu",
                "org": "Department of Oncology"
            },
            {
                "name": "Wei Liu",
                "org": "Department of Oncology"
            }
        ],
        "title": "Expression and mechanism of PinX1 and telomerase activity in the carcinogenesis of esophageal epithelial cells",
        "abstract": "Esophageal tissues were collected from an esophageal carcinoma high-risk area of China and were used to detect the telomere length and the expression of human telomerase reverse transcriptase (hTERT) by immuhistochemistry and fluorescence in situ hybridization; esophageal carcinoma tissues, paired-adjacent mucosa and paired normal mucosa were obtained from resected surgical specimens of esophageal squamous cell carcinoma in order to determine telomerase activity and expression of hTERT and Pin2/TRF1 interacting protein X1 (PinX1) by telomeric repeat amplification protocol-silver staining, RT-PCR and flow cytometry (FCM). The cell proliferation and apoptosis of Eca109 cells were analyzed by FCM and MTT assay. We found that the length of telomere DNA decreased and hTERT protein expression increased in the carcinogenesis of esophageal epithelial cells; telomerase activity was significantly upregulated followed by a decrease of PinX1 expression in esophageal carcinoma compared with dysplasia and normal patients, which notably correlated with grade and lymph node metastasis. Overexpression of PinX1 inhibited cell growth, arrested cells at the G0/G1 stage and induced cell apoptosis in Eca109 cells. In addition, PinX1 overexpression significantly inhibited telomerase activity. In conclusion, the length shortening of telomere was an important characteristic in the carcinogenesis of esophageal epithelial cells, followed by increase of telomerase activity and downregulation of PinX1. Overexpression of PinX1 blocked Eca109 cell proliferation and induced cell apoptosis by downregulating telomerase activity.",
        "keywords": [
            "Apoptosis",
            "Esophageal carcinoma",
            "Human telomerase reverse transcriptase",
            "Pin2/TRF1 interacting protein X1",
            "Telomerase activity"
        ],
        "venue": "Oncology Reports",
        "year": 2013,
        "id": "TTQKywlI"
    },
    "x2YOR1ZW": {
        "authors": [
            {
                "name": "Lei Wang",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Baoen Shan",
                "org": "Center for Scientific Research"
            },
            {
                "name": "Liang Liu",
                "org": "FACS Lab. of Tumor Institute"
            },
            {
                "name": "Xianli Meng",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Shijie Wang",
                "org": "Department of Thoracic Surgery"
            }
        ],
        "title": "Effects of specific CTL activated by interleukin-27 gene-modified DC on growth of transplanted tumor of human esophageal carcinoma in nude mice",
        "abstract": "Objective: To investigate the effects of the specific CTL activated by IL-27 gene-modified DC on the growth of transplantated tumor of human esophageal carcinoma and to study the effects of IL-27 on cell apoptosis and its mechanisms. Methods: The human DC/IL-27 cells secreting IL-27 were successfully obtained using gene transfection. After the nude mice models of transplantated tumor of human esophageal carcinoma were established, the mice were immunized with specific CTL activated by IL-27 gene-modified DC loaded with esophageal tumor lysate (DC/IL-27-Ag). The volume and mass of the transplantated tumors were measured. The cell apoptosis in the tumor was determined by TUNEL. The cell cycle and apoptotic rate of transplantated tumors at G ",
        "keywords": [
            "Dendritic cells",
            "Esophageal neoplasm",
            "Immunotherapy",
            "Interleukin-27",
            "Retrovirus"
        ],
        "venue": "Chinese Journal of Clinical Oncology",
        "year": 2011,
        "id": "x2YOR1ZW"
    },
    "ch3ztVem": {
        "authors": [
            {
                "name": "Jing Wang",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Liang Liu",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jin-Mei Li",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jiang-Hui Liu",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Jian-Wen Guo",
                "org": "Department of FCM Analysis"
            },
            {
                "name": "Lian-Fu Zuo",
                "org": "Department of FCM Analysis"
            }
        ],
        "title": "The inhibitory effect of artesunate on human esophageal carcinoma is associated with modulation of CDC25A and TGF\u03b2",
        "abstract": "Objective: To observe the effects of artesunate (Art) on the proliferation of human esophageal carcinoma Eca109 cell line and xenograft tumors in nude mice, and explore the relationship between Art-induced cell cycle arrest and the expressions of CDC25A and transforming growth factor beta (TGF\u03b2). Methods: The inhibitory effect of Art on proliferation of human esophageal carcinoma Eca109 cells and normal human peripheral blood mononuclear cells (hPBMC) at different concentrations were determined by MTT assay. The changes of cell cycle distribution of tumor cells were determined by flow cytometry (FCM). The inhibitory effects of Art on the growth of transplanted human esophageal carcinoma in nude mice was observed. The expression of CDC25A mRNA was examined by reverse transcriptase-polymerase chain reaction (RT-PCR). The protein expressions of CDC25A and TGF\u03b2 were measured by Western blotting. Results: Art significantly inhibited the proliferation of Eca109 cells with the IC",
        "keywords": [
            "Artesunate",
            "Cell cycle proteins",
            "Esophageal neoplasms",
            "Xenograft model antitumor assays"
        ],
        "venue": "Tumor",
        "year": 2007,
        "id": "ch3ztVem"
    },
    "aj1nwGbu": {
        "authors": [
            {
                "name": "Lei Wang",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Bao-En Shan",
                "org": "Research Center"
            },
            {
                "name": "Liang Liu",
                "org": "Flow Cytometry Laboratory of Tumor Institute"
            },
            {
                "name": "Xian-Li Meng",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Shi-Jie Wang",
                "org": "Department of Thoracic Surgery"
            }
        ],
        "title": "In vitro study on anti-esophageal cancer immunity induced by antigen-sensitized and interleukin 27 gene-modified dendritic cells",
        "abstract": "Objective: To investigate the anti-esophageal cancer immunity induced by antigen-sensitized and interleukin 27 (IL -27) gene-modified dendritic cells (DCs). Methods: DCs isolated from the peripheral blood of patients with esophageal cancer were modified by recombinant retrovirus-mediated IL -27 gene, and then sensitized by the cleaved products from esophageal carcinoma Eca109 cells by using repeated freezing-thawing method. The secretion levels of IL-27, IL-12 and interferon-\u03b3 (IFN-\u03b3) in culture supernatant of DCs and the level of IFN-\u03b3 in cytotoxic T lymphocytes (CTLs) were examined by ELISA method. The expression levels of CD1a, CD83, CD80 and CD86 molecules on DCs surface were measured by FCM. The proliferative activity of T lymphocytes and the killing efficacy of CTLs against Eca109 cells induced by DCs were evaluated by MTT method. Results: After being modified by IL -27 gene and sensitized by tumor antigen, the secretion levels of IL-12[(107.85\u00b17.20) ng/L], IL-27[(430.39\u00b110.12) ng/L] and IFN-\u03b3[(411.97\u00b117.80) ng/L] of DCs were increased, and the expressions of CD83[(82.67\u00b17.92)%], CD80[(78.33\u00b17.31)%] and CD86[(85.33\u00b14.32)%] molecules were also elevated. Meanwhile, the proliferation capacity of autologous T lymphocytes was enhanced after stimulation by DCs, and the secretion level of IFN-\u03b3[(751.50\u00b131.30) ng/L] in the culture supernatant of DCs was increased. The DCs modified by IL -27 gene and sensitized by tumor antigen could significantly induce the strongest cytotoxicity of antigen-specific CTLs against Eca109 cells (P<0.01). Conclusion: IL -27 gene modification enhances the capacity of DCs in inducing autologous T lymphocytes to generate specific antitumor immunity against esophageal carcinoma. The mechanism of this immune response may be closely relevant to the activation of the second signal for presenting antigen cells such as DCs, the promoted capacity of DCs secreting IL-27 and IL-12, and the activation of T cells resulting in the enhanced capacity of CTLs excreting IFN-\u03b3. Copyright\u00a9 2011 by TUMOR.",
        "keywords": [
            "Antigen-sensitization",
            "Dendritic cells",
            "Esophageal neoplasms",
            "Immunotherapy",
            "Interleukin-27",
            "Transfection"
        ],
        "venue": "Tumor",
        "year": 2011,
        "id": "aj1nwGbu"
    },
    "uUiTKzup": {
        "authors": [
            {
                "name": "Lei Wang",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Bao-En Shan",
                "org": "Research Center"
            },
            {
                "name": "Liang Liu",
                "org": "FCM Lab. of Tumor Institute"
            },
            {
                "name": "Ming He",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Xian-Li Meng",
                "org": "Department of Thoracic Surgery"
            },
            {
                "name": "Shi-Jie Wang",
                "org": "Department of Thoracic Surgery"
            }
        ],
        "title": "CD1a and CD83 expression in tumor infiltrating dendritic cells of esophageal squamous cell carcinoma and tumor-infiltrating lymph node",
        "abstract": "Objective: To investigate CD1a and CD83 expression in tumor infiltrating dendritic cell (TIDC) of esophageal squamous cell carcinoma (ESCC) and tumor-infiltrating lymph node tissues, and to discuss its relationship with the clinical pathological characteristics of esophageal carcinoma. Methods: Seventy-eight paraffin samples were obtained from pathologically diagnosed esophageal carcinoma patients in the fourth hospital of Hebei medical university during 2002 to 2003. Flow cytometry was used to examine the expression of CD1a and CD83 on TIDC in 78 esophageal carcinoma tissues, 24 normal esophageal mucosal samples, 35 normal lymph nodes and 32 tumor-infiltrating lymph nodes. Results: (1) The expression of CD1a and CD83 in ESCC tissues was significantly lower than those in the normal esophageal mucosa (P < 0.05). (2) CD1a expression was not correlated with the tumor infiltration, clinical stage and lymph node metastasis of esophageal carcinoma (all P > 0.05), while CD83 expression was correlated with the clinical stage and lymph node metastasis (all P < 0.05). (3) There was no significant difference in CD1a expression between normal lymph node and tumor-infiltrating lymph node (P > 0.05), but CD83 expression in tumor-infiltrating lymph node was less than that in the normal lymph node (P < 0.05). Conclusion: The expression of CD83 in TIDC can reflect the local immune status of esophageal carcinoma, and also plays an important role in the development and progression of esophageal carcinoma. CD83 expression may serve as a biomarker for evaluating biological characteristics of esophageal carcinoma.",
        "keywords": [
            "CD1a",
            "CD83",
            "Dendritic cell",
            "Esophageal squamous cell carcinoma",
            "Tumor-infiltrating lymph node"
        ],
        "venue": "Chinese Journal of Cancer Biotherapy",
        "year": 2009,
        "id": "uUiTKzup"
    },
    "o9IOTHaz": {
        "authors": [
            {
                "name": "Lei Wang",
                "org": ""
            },
            {
                "name": "Li-Hua Liu",
                "org": ""
            },
            {
                "name": "Qing-Yi Liu",
                "org": ""
            },
            {
                "name": "Lin Wang",
                "org": ""
            },
            {
                "name": "Liang Liu",
                "org": ""
            },
            {
                "name": "Bao-En Shan",
                "org": ""
            }
        ],
        "title": "Effects of specific cytotoxicity T lymphocyte activated by interleukin-27 gene modified DC and loaded with esophageal tumor lysate on growth of transplantation tumor of human esophageal carcinoma in nude mice",
        "abstract": "Objective: To investigate the effect of specific cytotoxicity T lymphocyte (CTL) activated by IL-27 gene modified DC and loaded with esophageal tumor lysate on the growth of transplantation tumor of human esophageal carcinoma in nude mice, and study the effect of IL-27 on cancer cell apoptosis and its mechanisms. Methods: With gene transfection method, human DC",
        "keywords": [
            "Dendritic cells",
            "Esophageal carcinoma",
            "Interleukins",
            "Retroviridae"
        ],
        "venue": "Medical Journal of Chinese People's Liberation Army",
        "year": 2014,
        "id": "o9IOTHaz"
    },
    "HWqkq2cv": {
        "authors": [
            {
                "name": "Liang Liu",
                "org": ""
            },
            {
                "name": "Jing Wang",
                "org": ""
            },
            {
                "name": "Jian-Wen Guo",
                "org": ""
            },
            {
                "name": "Jiang-Hui Liu",
                "org": ""
            },
            {
                "name": "Lian-Fu Zuo",
                "org": ""
            }
        ],
        "title": "Inhibitory effect of artesunate on human esophageal carcinoma cells and the possible mechanism",
        "abstract": "Objective: To explore the inhibitory effect of artesunate (Art) on human esophageal carcinoma cells and to study the related mechanism. Methods: Nude mice were inoculated with Eca109 cells subcutaneously on the left upper limbs to establish esopbageal carcinoma model. The model mice were divided into 5 groups: first group received 100 mg/kg Art, second group 200 mg/kg Art, third group 300 mg/kg Art, forth group 3 mg/ kg cisplatin (DDP), and the fifth group received normal saline. Mass and volume changes of transplant tumors in different groups were observed. Flow cytometry was used to detect the cell cycle, apoptosis, and the expression of CDC25A protein, Smad3 protein and TGF-\u03b2 protein in the transplanted tumors in mouse model. RT-PCR was used to detect the expression of CDC25A, Smad3 and TGF-\u03b2 mRNA in the transplanted tumors. Results: Nude mouse model bearing human esophageal carcinoma was successfully created. Compared with the control group, the volume and mass of transplant tumors in Art groups were significantly smaller (P < 0.05 or P < 0.01); the tumor inhibitory rate was highest in 200 mg/kg Art group, similar that in DDP group. The proportions of cells at G",
        "keywords": [
            "Apoptosis",
            "Artesunate",
            "Cell division cycle 25A (CDC25A)",
            "Esophageal squamous cell carcinoma",
            "Smad3",
            "Transforming growth factor-\u03b2"
        ],
        "venue": "Chinese Journal of Cancer Biotherapy",
        "year": 2008,
        "id": "HWqkq2cv"
    },
    "4JJTStqY": {
        "authors": [
            {
                "name": "K. Shimasaki",
                "org": "Department of Subtropical Agriculture"
            },
            {
                "name": "T. Wang",
                "org": "National University Corporation"
            },
            {
                "name": "Y. Nishimura",
                "org": "Department of Subtropical Agriculture"
            },
            {
                "name": "N.T. Huyen",
                "org": "Department of Pharmacognosy"
            },
            {
                "name": "S. Neera",
                "org": "Department of Horticulture"
            },
            {
                "name": "T. Hsiung",
                "org": "Department of Horticulture and Biotechnology"
            },
            {
                "name": "C. Huang",
                "org": "Department of Horticulture"
            }
        ],
        "title": "Effect of chitosan and jasmonic acid related compounds on shoot formation from rhizome cultures of an oriental Cymbidium species",
        "abstract": "We examined the effect of a jasmonic acid related compound (n-propyl dihydrojasmonate; PDJ), methl jasmonate (Me-JA), and chitosan H added to modified MS medium on shoot formation of a Cymbidium species (C. kanran Makino). Single addition of Me-JA was effective for shoot formation from rhizome cultures. Combination treatments of chitosan H with Me-JA were also effective for shoot formation from rhizome cultures. Percentage of rooting was highest (64.3%) in a combination treatment of 1 mg L",
        "keywords": [
            "Chitosan",
            "Cymbidium",
            "Jasmonic acid derivatives",
            "Rhizome"
        ],
        "venue": "Acta Horticulturae",
        "year": 2010,
        "id": "4JJTStqY"
    },
    "LC4Wypvk": {
        "id": "LC4Wypvk",
        "title": "Research on stability of tunable TEA CO_2 laser resonator",
        "abstract": "Considering the stability of the optical bridge of tunable TEA CO2 laser resonator,the material and shape of the mirror-supporting board were emphatically investigated by analyzing the deformation of the board.Finite element model of the board was created.Using finite element analysis software,the deformation of boards of different materials and shapes was calculated and discussed.Analysis results indicate that the triangular aluminum board is the best,and the deformation of triangular aluminum board with thickness of 40 mm is 1.27 \u03bcm.This paper provides theoretical evidence for designing a stable resonator of tunable TEA CO2 laser.",
        "keywords": [
            "finite element analysis",
            "optical bridge",
            "TEA CO2 laser",
            "resonator structure",
            "deformation"
        ],
        "authors": [
            {
                "name": "ZENG Yuan",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China;Graduate School of Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "TAN Rong-qing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Laser & Infrared",
        "year": 2009
    },
    "HQ41HW8j": {
        "id": "HQ41HW8j",
        "title": "Investigation on Rapidly Tunable Technology of Grating Line Selection TEA CO_2 Laser",
        "abstract": "A rapidly tunable system of grating line selection TEA CO_2 laser with the direct drive AC servomotor is developed.The conformation and design of that system is introduced,including hardware making,software designing and flow running of that system.The elementary experiment investigation is completed.",
        "keywords": [
            "rapidly tunable",
            "CO_2 laser",
            "direct drive AC servomotor"
        ],
        "authors": [
            {
                "name": "CHENG Yong-qiang",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China;Graduate University of the Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "TAN Rong-qing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "ZHENG Yi-jun",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "KE Chang-jun",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "WANG Dong-lei",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Kuo-hai",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Laser & Infrared",
        "year": 2006
    },
    "ghBhG2QD": {
        "id": "ghBhG2QD",
        "title": "A comparison study of data mining algorithms in CHD clinical application",
        "abstract": "In China,more and more people take traditional chinese medicine(TCM) to heal coronary heart disease(CHD).Syndrome is the core of TCM theory.Predicting the kind of syndrome for a CHD patient is an important and challenge work.In this paper,based on 1069 cases of clinical epidemiology data of CHD,we employ four kinds of data mining methods and a statistical method as prediction model to learn and classify the data.We use the method of 10\ue4d3fold cross validation to measure the three performance measures,the sensitivity,specificity and accuracy of each algorithm and also record the computation time of each algorithm.We select the best algorithm from each category and put all the algorithms to compare with each other.The results show that Bayesian network is the best in the Bayes methods,with 90.17% sensitivity,88.89%specificity,89.24% accuracy and its computation time is 0.53s.RBFN is the best in the neural network counterpart,sensitivity is 84.07%,specificity 94.23%,accuracy 91.49%,computation time is 1.03s.while Libsvm is the best in SVM category,sensitivity 91.19%,specificity 93.15%,accuracy 92.61%,computation time 1.0s.ADTree is the best in the case of decision tree with a sensitivity of 83.73%,specificity of 95.99% and accuracy 92.61%,computation time 2.78s.Logistic regression's sensitivity is 88.14%,specificity 94.44%,accuracy 92.70% and computation time is 1.09s.Synthesizing all performance measures,SVM is the best,logistic regression is the second,the following is decision tree and Bayes,neural network comes worst.The comparison study here paves a mathematic and physical basis for predicting syndrome in CHD.",
        "keywords": [
            "coronary heart disease",
            "data mining algorithms",
            "logistic regression",
            "syndrome",
            "comparison study"
        ],
        "authors": [
            {
                "name": "CHEN Jianxin",
                "org": " Key Laboratory of Complex Systems and Intelligence ScienceInstitute of Automation,Chinese Academy of Sciences,Beijing ; Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "XI Guangcheng",
                "org": " Key Laboratory of Complex Systems and Intelligence ScienceInstitute of Automation,Chinese Academy of Sciences,Beijing "
            },
            {
                "name": "WANG Wei",
                "org": " Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "ZHAO Huihui",
                "org": " Beijing University of Chinese Medicine,Beijing "
            },
            {
                "name": "CHEN Jing",
                "org": " Key Laboratory of Complex Systems and Intelligence ScienceInstitute of Automation,Chinese Academy of Sciences,Beijing "
            }
        ],
        "venue": "Beijing Biomedical Engineering",
        "year": 2008
    },
    "njbyJXPy": {
        "id": "njbyJXPy",
        "title": "Automatic Resonator Adjustment System for Tunable TEA CO_2 Laser",
        "abstract": "An automatic resonator adjustment system is designed for a grating tuning TEA CO2 laser with high repetition rate and high output power.The automatic laser spot collection and analysis are realized by a computer-controlled system,which decide the best grating position and consequently adjust it.The construction and performance of the system are presented along with a description of its control software development.The mechanism of capturing single pulse CO2 laser spot is analyzed.Therefore a synchronously triggering method by outputting a signal from the computer through its process of image captures is proposed.The experiment shows that high quality single pulse two-dimensional CO2 laser spot can be fully and stably collected within 100ms.",
        "keywords": [
            "grating tuning",
            "TEA CO2 laser",
            "uncooled IRFPA thermal imager",
            "image collection"
        ],
        "authors": [
            {
                "name": "AN Ran",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "TAN Rong-qing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "KE Chang-jun",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "ZHENG Yi-jun",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "WANG Dong-lei",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Laser & Infrared",
        "year": 2007
    },
    "cosx3JaP": {
        "id": "cosx3JaP",
        "title": "Rapidly tunable experiment of grating line selectable TEA CO_2 laser",
        "abstract": "A new rapidly tunable system of grating line selectable TEA CO2 laser with the direct drive AC servomotor is developed.A series of experimental investigation is completed,includes the systemic debug experiment,the single pulse running tunable experiment and the rapidly tunable experiment.85 lines of tunable output are obtained,the energy of 18 lines is more than 10 J.In the rapidly trigging experiment,the tunable outputs of two random lines among the whole CO2 laser spectrum and two adjacent lines in the same transition band are realized respectively in 60 ms and 20 ms.The technology will be used in rapidly tuning of high power and wide spectrum range tunable TEA CO2 laser,it has more reference value to design and develop the rapidly tunable output of the high power high repetition rate tunable TEA CO2 laser.",
        "keywords": [
            "Rapidly tuning",
            "Grating line selection",
            "TEA CO_2 laser",
            "Direct drive AC servomotor"
        ],
        "authors": [
            {
                "name": "CHENG Yong-qiang",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China;Graduate University of the Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "TAN Rong-qing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "ZHENG Yi-jun",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "WANG Dong-lei",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "CHEN Jing",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "SHI Hai-xia",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "KE Chang-jun",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            },
            {
                "name": "ZHANG Kuo-hai",
                "org": "Institute of Electronics,Chinese Academy of Sciences,Beijing ,China"
            }
        ],
        "venue": "Infrared and Laser Engineering",
        "year": 2007
    },
    "KIIWLpsv": {
        "id": "KIIWLpsv",
        "title": "The Identification Technology of CO_2 Laser Spots Quality Based on MATLAB",
        "abstract": "By using the IR thermal imaging system,image grab card,direct drive AC servomotor and the computer,a laser spot identification system is developed to gain the best spot for the tunable TEA CO_2 laser.Through experiments,the identification of CO_2 laser spots quality is realized successfully.",
        "keywords": [
            "image processing",
            "TEA CO_2 laser",
            "grating tunning"
        ],
        "authors": [
            {
                "name": "CHEN Jing",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China;Graduate University of the Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "TAN Rong-qing",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "AN Ran",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "CHENG Yong-qiang",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "KE Chang-jun",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "ZHENG Yi-jun",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China"
            },
            {
                "name": "WANG Dong-lei",
                "org": "Institute of Electronics,Chinese Academy of Science,Beijing ,China"
            }
        ],
        "venue": "Laser & Infrared",
        "year": 2006
    },
    "k49YnzZY": {
        "id": "k49YnzZY",
        "title": "The strong ground motion observation for the Wenchuan aftershock",
        "abstract": "In this paper, the mobile strong ground motion observation for the destructive earthquake is introduced. Considering the characteristics\n and its spatial distributions of aftershock, 59 strong ground motion instruments were installed along the Longmenshan fault\n area, and more than 2 000 records have been accumulated. It shows that it is necessary to perform the mobile strong ground\n motion observation after the destructive earthquake, and the precious collected data could be applied for further research.",
        "keywords": [
            "wenchuan earthquake",
            "strong ground motion",
            "mobile observation"
        ],
        "authors": [
            {
                "name": "Ruizhi Wen",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Zhenghua Zhou",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Xiaojun Li",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Cheng Yang",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Yuhuan Wang",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Quan Liu",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Xiaotao Yin",
                "org": "China Earthquake Administration Institute of Engineering Mechanics Harbin 150080 China"
            },
            {
                "name": "Mindu Zhou",
                "org": "Earthquake Administration of Gansu Province Lanzhou 730000 China"
            },
            {
                "name": "Jianwen Cui",
                "org": "Earthquake Administration of Yunnan Province Kunming 650224 China"
            }
        ],
        "venue": "Earthquake Science",
        "year": 2009
    },
    "6HNl3vnI": {
        "id": "6HNl3vnI",
        "title": "Strong ground motion observation for Wenchuan aftershocks",
        "abstract": "After the great Wenchuan earthquake broke out on May 12, 2008, more than 10 thousands of aftershocks occurred. China Earthquake Administration performed mobile observation of strong ground motion induced by the aftershocks. With the characteristics and spatial distribution of the aftershocks considered, 59 strong ground motion instruments were installed along Longmenshan fault zone, and more than 2 000 records have been accumulated. In this paper, the strong motion records for the largest M6. 4 aftershock of May 25, 2008 are preliminary processed and the attenuation relation is obtaied. This work shows that it is necessary to perform mobile strong ground motion observation immediately after occurrence of destructive earthquakes, and this would offer precious data for further research.",
        "keywords": [
            "Mobile observation",
            "Strong ground motion",
            "Wenchuan earthquake"
        ],
        "authors": [
            {
                "name": "Ruizhi Wen",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Zhenghua Zhou",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Xiaojun Li",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Cheng Yang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Yuhuan Wang",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Quan Liu",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Xiaotao Yin",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            },
            {
                "name": "Mindu Zhou",
                "org": "Geological Survey of Gansu Province(Earthquake Administration of Gansu Province,Geological Survey of Gansu Province),Lanzhou,China"
            },
            {
                "name": "Jianwen Cui",
                "org": "Seismological Bureau of Yunnan Province(Seismological Bureau of Yunnan Province,Earthquake Administration of Yunnan Province,Seismological Bureau of Yunnan Prov.),Kunming,China"
            },
            {
                "name": "Yefei Ren",
                "org": "China Earthquake Administration(^ China Earthquake Administration),Beijing,China"
            }
        ],
        "venue": "Acta Seismologica Sinica",
        "year": 2009
    },
    "TgRnnbKh": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Dezhan Ye",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Minghua Zhang",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Xi Zhang",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            }
        ],
        "title": "Structure and properties of lignosulfonate calcium/polyvinyl alcohol blends",
        "abstract": "In order to develop environment-friendly polymer materials, blend materials of polyvinyl alcohol (PVA) and lingosulfonate calcium (HLS) were prepared. The effects of HLS on the thermal and mechanical properties of PVA films and the plasticizing effect of glycerol on HLS/PVA blend films were studied. It has been found that strong interactions and good compatibility occur in HLS/PVA blends. HLS improves the strength and thermal stability of PVA and reduces the crystallinity. 25% HLS improves the tensile strength and thermal stability of PVA by 165% and 20\u2103, respectively; glycerol plays a typical plasticizer role in HLS/PVA blends suggested by the decreasing glass transition temperature, melting point, crystallinity, tensile strength and thermal stability; 30% glycerol plasticized blend shows good comprehensive properties. The thermal stability is 10\u2103 higher than that of pure PVA, and its tensile strength and elongation at break are 47.62 MPa and 621.64%, respectively.",
        "keywords": [
            "Glycerol",
            "Lignosulfonate calcium",
            "Mechanical properties",
            "Polyvinyl alcohol",
            "Thermal stability"
        ],
        "venue": "Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering",
        "year": 2015,
        "id": "TgRnnbKh"
    },
    "kKvMoeHj": {
        "authors": [
            {
                "name": "Qian Zhao",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Bin Xu",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Li Jiang",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Hua Dai",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            },
            {
                "name": "Xi Zhang",
                "org": "State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University"
            }
        ],
        "title": "Structure and properties of starch/poly (lactic acid) blends plasticized by acetyl tributyl citrate",
        "abstract": "Starch/ poly (lactic acid) (PLA)blends plasticized with acetyl tributyl citrate (ATBC) were prepared by melt blending. Infrared absorption spectroscopy (IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA) and mechanical test were adopted to study the effects of ATBC on the structure and performance of starch/PLA blends. The results show that ATBC can form strong interactions between PLA and starch molecules, thus disrupting the inter and intra chain hydrogen bonding of starch and PLA chains and reducing the crystallinity of blends; compared with crude starch/PLA blend, the interfacial bonding strength between starch and PLA is improved, which is suggested by the better compatibility in ATBC plasticized blends. The glass transition temperature (T<inf>g</inf>) and melting point (T<inf>m</inf>) of starch/PLA blends decline with addition of ATBC, showing improved processing properties; meanwhile, the thermal stability of the blends could not be affected by ATBC; ATBC can significantly improve the flexibility of starch/PLA blends, and the elongation of starch/PLA blends containing 20% ATBC can reach 365%.",
        "keywords": [
            "Acetyl tributyl citrate",
            "Crystalline structure",
            "Mechanical property",
            "Plasticizers",
            "Polylactic acid",
            "Starch",
            "Thermal performance"
        ],
        "venue": "Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering",
        "year": 2015,
        "id": "kKvMoeHj"
    },
    "jgIZ2rCs": {
        "authors": [
            {
                "name": "De zhan Ye",
                "org": "State Key Laboratory of Polymer Material Engineering, Sichuan University"
            },
            {
                "name": "Li Jiang",
                "org": "State Key Laboratory of Polymer Material Engineering, Sichuan University"
            },
            {
                "name": "Chao Ma",
                "org": "Petroleum Engineering College of Yangtze University"
            },
            {
                "name": "Ming-hua Zhang",
                "org": "State Key Laboratory of Polymer Material Engineering, Sichuan University"
            },
            {
                "name": "Xi Zhang",
                "org": "State Key Laboratory of Polymer Material Engineering, Sichuan University"
            }
        ],
        "title": "The graft polymers from different species of lignin and acrylic acid: Synthesis and mechanism study",
        "abstract": "The influence of lignin species on the grafting mechanism of lignosulfonate (from eucalyptus and pine, recorded as HLS and SLS, respectively) with acrylic acid (AA) was investigated. The graft polymers were confirmed by the absorption of carbonyl groups in the FTIR spectra. The decreasing phenolic group's content (Ph-OH) is not only due to its participation as grafting site but also to the negative effect of initiator. In the initial period (0-60. min), HLS and SLS both accelerate the polymerization of AA. Additionally, Ph-OH group's content is proportional to product yield (Y%), monomer conversion (C%) and grafting efficiency (GE%), strongly indicating that it acts as active center. Nevertheless, compared with HLS, Y% and C% in SLS grafting system are lower though it has higher Ph-OH group's content, which is due to the quinonoid structure formed by the self-conjugated of phenoxy radical in Guaiacyl unit. Finally, the lignosulfonate grafting mechanism was proposed. \u00a9 2013 Elsevier B.V.",
        "keywords": [
            "Acrylic acid",
            "Grafting mechanism",
            "Lignin species",
            "Phenolic group"
        ],
        "venue": "International Journal of Biological Macromolecules",
        "year": 2014,
        "id": "jgIZ2rCs"
    },
    "sDiFlgU2": {
        "authors": [
            {
                "name": "Qiling Li",
                "org": ""
            },
            {
                "name": "Qian Zhao",
                "org": ""
            },
            {
                "name": "Hua Dai",
                "org": ""
            },
            {
                "name": "Ronghua Huang",
                "org": ""
            },
            {
                "name": "Bing Liang",
                "org": ""
            },
            {
                "name": "Xi Zhang",
                "org": ""
            }
        ],
        "title": "Synthesis and characterization of calcium lignosulfonate grafted with p-styrenesulfonate and maleic anhydride",
        "abstract": "The graft modification calcium lignosulfonate thinners (SMLS) for drilling fluid were synthesized with sodium p-styrenesulfonate, maleic anhydride and calcium lignosulfonate, using ammonium persulfate as initiator. The structures of the copolymers were characterized by FT-IR spectra, and their viscosity reduction-properties in fresh water, saline-based, calcium-based drilling fluid were studied. The results show that SMLS can effectively reduce the viscosity and yield value by breaking the original gel structure in drilling fluid, and the viscosity reduction rates are 80.77%, 75.00%, 70.50% in fresh water, saline-based, calcium-based drilling fluid respectively, which indicates that SMLS is of excellent viscosity reduction properties and salt tolerance. The viscosity reduction rate of SMLS is almost not affected by the aging temperature under 150\u00b0C, and it is still about 70% even treated at 200\u00b0C for 16 h, when the dosage of SMLS is 0.4%.",
        "keywords": [
            "Drilling fluid additive",
            "Grafting-modified lignosulfonate copolymer",
            "Maleic anhydride",
            "p-styrenesulfonate",
            "Performance evaluation",
            "Thinning agent"
        ],
        "venue": "Gaofenzi Cailiao Kexue Yu Gongcheng/Polymeric Materials Science and Engineering",
        "year": 2014,
        "id": "sDiFlgU2"
    },
    "9MqPj8nA": {
        "id": "9MqPj8nA",
        "title": "Analysis on Technical Application of MA Lin in Table Tennis Competition in Beijing Olympic Games",
        "abstract": "Through using the method of literature review,video observation,mathematical statistics and sub-target assessment,the paper analyzes deeply technique and tactics of MA Lin in Beijing Olympic Games and gets the following conclusions:The advantage of serving attack is obvious,and the key of victory is the first attack with high quality,the return of service,which is the most stable,is the basic guarantee of victory,the stalemate paragraph is the weak part.At the open and the end of the game,the tactics of MA Lin is slightly conservative,the ability of attack with forehand is excellent,but the ability of attack in the mid-table and far-table with backhand needs to be further improved.",
        "keywords": [
            "technique",
            "table tennis",
            "MA Lin",
            "tactic",
            "Beijing",
            "Olympics Games"
        ],
        "authors": [
            {
                "name": "CHENG Hong",
                "org": " Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,Jiangsu China"
            },
            {
                "name": "BAI Jie",
                "org": " Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,Jiangsu China"
            },
            {
                "name": "QIAN Lai",
                "org": " Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,Jiangsu China"
            }
        ],
        "venue": "Bulletin of Sport Science & Technology",
        "year": 2010
    },
    "lBNBA4IA": {
        "id": "lBNBA4IA",
        "title": "Reexamination and reconstruction of the table tennis technology classification system in China",
        "abstract": "According to classification rules based on formal logic as well as the essential attribute of the table tennis event,the authors studied the technology classification system described in table tennis textbooks currently effective in China,and found the it had such problems as mismatching extensions,overlapping subitems,non-unified classification standards etc.Aiming at these problems existing in the currently effective classification system,and basing classifica-tion standards on \"racket holding\",\"rubber performance\",\"physiological structure\",\"ball hitting time\" etc.,the authors established a system of classification of technologies such as \"transversal racket holding and vertical racket holding\",\"reversely glued rubber,normally glued rubber,granule-free rubber,long-granule rubber\",\"forehand and backhand\",\"ball serving and ball returning\" etc.,thus forming a new table tennis technology classification system.",
        "keywords": [
            "table tennis",
            "competition and training",
            "technology classification system",
            "China"
        ],
        "authors": [
            {
                "name": "CHENG Hong",
                "org": "Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,China"
            },
            {
                "name": "YU Xiao-dong",
                "org": "Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,China"
            },
            {
                "name": "QIAN Lai",
                "org": "Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,China"
            }
        ],
        "venue": "Journal of Physical Education",
        "year": 2012
    },
    "WsllLrxH": {
        "id": "WsllLrxH",
        "title": "Technique and tactics of defeat for Chinese Women Team in the 50th World Table Tennis Championship",
        "abstract": "By the methods of literature,video observation,mathematical statistics and the sub-index evaluation,analyzing the final lost three games for the technique and tactics in the 50th World Table Tennis Championship of Chinese Women Team,it has been found that technical and tactical expertise of team members are more prominent,but unstable to play;technology is not comprehensive enough,and there are some technical flaws;they can't very well deal with the relationship between stability and fierce,attack and defense,fast and slow,so easy to go to extremes in the competition.",
        "keywords": [
            "World Table Tennis",
            "Chinese Women Team",
            "technique and tactics"
        ],
        "authors": [
            {
                "name": "CHENG Hong",
                "org": "PE Department,Nanjing University of Information Science and Technology,Nanjing ,China"
            }
        ],
        "venue": "Shandong Sports Science & Technology",
        "year": 2010
    },
    "cqAEPsDL": {
        "id": "cqAEPsDL",
        "title": "Analysis on Tactic Application of Attach after Serve of Ma Lin in Table Tennis Match of Beijing Olympic Games",
        "abstract": "Through the methods of literature review,video observation,mathematical statistics and etc.,this paper deeply analyses the tactics of attack after serve of Malin in Beijing Olympic Games.The study reveals that attach after serve is the main tactic for Malin to get points.But his stand positions of serving,scoring means and drop points are lack of variety.The routines of attach after serve tactics are rich.The attacking sense is very proactive.",
        "keywords": [
            "table tennis",
            "Beijing Olympic Games",
            "tactic",
            "Malin"
        ],
        "authors": [
            {
                "name": "CHENG Hong",
                "org": " Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,Jiangsu China"
            },
            {
                "name": "LI Zhong-xiang",
                "org": " Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,Jiangsu China"
            },
            {
                "name": "ZHANG Lin",
                "org": " Department of Physical Education,Nanjing University of Information Science and Technology,Nanjing ,Jiangsu China"
            }
        ],
        "venue": "Bulletin of Sport Science & Technology",
        "year": 2011
    },
    "OQf6Kok5": {
        "id": "OQf6Kok5",
        "title": "Analysis on Aggress Tactics of Serve of Malin in Table Tennis of the Beijing Olympic Games",
        "abstract": "By Using literature,video observation,matheatical statistics methods,this paper has a depth analysis on tactics of serve to attack of Ma Lin in the Beijing Olympic Games and conclusion:aggress tactics are the main of tactics of getting points;serve stations,means,methods and impact point are too single,the changes of serving spin are many and differences are great between the rotations.The routine of grab tactics are more,attacking sense is very initiative,the short balls of the high throw goes near the net,the tactics of grab attacking with forehand or sideways are used best.",
        "keywords": [
            "table tennis",
            "Beijing Olympic Game",
            "Malin",
            "tactics"
        ],
        "authors": [
            {
                "name": "Cheng Hong",
                "org": "P.E.Department,Nanjing University of Information Science and Technology,Nanjing,,Jiangsu,China"
            },
            {
                "name": "Bai Jie",
                "org": "P.E.Department,Nanjing University of Information Science and Technology,Nanjing,,Jiangsu,China"
            },
            {
                "name": "Song Yilin",
                "org": "P.E.Department,Nanjing University of Information Science and Technology,Nanjing,,Jiangsu,China"
            }
        ],
        "venue": "Journal of Jilin Institute of Physical Education",
        "year": 2011
    },
    "iPtP911r": {
        "authors": [
            {
                "name": "Liyan Yang",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            },
            {
                "name": "Qiannan Liang",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            },
            {
                "name": "Ke Shen",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            },
            {
                "name": "Li Ma",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            },
            {
                "name": "Na An",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            },
            {
                "name": "Weiping Deng",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            },
            {
                "name": "Zhewei Fei",
                "org": "Department of General Surgery, Xinhua Hospital Chongming Branch, Shanghai Jiaotong University School of Medicine"
            },
            {
                "name": "Jianwen Liu",
                "org": "Department of Molecular and Cellular Pharmacology, Biomedical Nanotechnology Center, State Key Laboratory of Bioreactor Engineering and oShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology"
            }
        ],
        "title": "A novel class I histone deacetylase inhibitor, I-7ab, induces apoptosis and arrests cell cycle progression in human colorectal cancer cells",
        "abstract": "Epigenetic mutations are closely associated with human diseases, especially cancers. Among them, dysregulations of histone deacetylases (HDACs) are commonly observed in human cancers. Recent years, HDAC inhibitors have been identified as promising anticancer agents; several HDAC inhibitors have been applied in clinical practice. In this study, we synthesized a novel N-hydroxyacrylamide-derived HDAC inhibitor, I-7ab, and examined its antitumor activity. Our investigations demonstrated that I-7ab exerted cytotoxicity toward and inhibited the growth of human cancer cell lines at micromolar concentrations. Among tested cells, HCT116 was the most sensitive one to the treatment of I-7ab. However, I-7ab displayed far less cytotoxicity in human normal cells. In HCT116 cells, I-7ab inhibited the expression of class I HDACs, especially that of HDAC3, and suppressed EGFR signaling pathway. With respect to the cytotoxic effect of I-7ab, it induced apoptosis via increasing the Bax/Bcl-2 ratio and suppressing the translocation of NF-\u03baB. Other than inducing apoptosis, I-7ab inhibited the expression of cyclin B1 and thereby arrests cell cycle progression at G2/M phase. Further analyses revealed potential role of p53 and p21 in I-7ab-induced apoptosis and cell cycle arrest. According to our findings, I-7ab may serve as a lead compound for potential antitumor drugs.",
        "keywords": [
            "Apoptosis",
            "Cell cycle arrest",
            "Colorectal cancer",
            "HDAC inhibitor",
            "I-7ab"
        ],
        "venue": "Biomedicine and Pharmacotherapy",
        "year": 2015,
        "id": "iPtP911r"
    },
    "ebV5c55V": {
        "authors": [
            {
                "name": "Z. Wu",
                "org": "College of Water Conservancy and Hydropower"
            },
            {
                "name": "J. Chen",
                "org": "College of Water Conservancy and Hydropower"
            },
            {
                "name": "B. Wen",
                "org": "College of Water Conservancy and Hydropower"
            }
        ],
        "title": "A new narrow-bound method for computing system failure probability",
        "abstract": "On the reliability analysis of structural system, the narrow-bound method is often used to compute the system failure probability. But it is difficult to calculate two-dimensional joint failure probability p",
        "keywords": [
            ""
        ],
        "venue": "Geotechnical Special Publication",
        "year": 2006,
        "id": "ebV5c55V"
    },
    "vAddftfx": {
        "authors": [
            {
                "name": "Kang Fei",
                "org": "Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering"
            },
            {
                "name": "Yi Chen",
                "org": "Institute of Geotechnical Engineering"
            },
            {
                "name": "Jun-Jun Wang",
                "org": "Institute of Geotechnical Engineering"
            }
        ],
        "title": "Experimental study on influence of reinforcing modes on behavior of piled embankment",
        "abstract": "In order to study the effect of the geosynthetic reinforcement on the behavior of the piled embankment, a series of three-dimensional model tests are carried out. In the tests, single and double layers of geotextiles or geogrids are used. The pile-soil stress ratio, stress reduction ratio, and vertical stress distribution in the embankment fill and differential settlement are compared with the data measured from the unreinforced embankment. It is found that the inclusion of geosynthetic reinforcements can enhance the efficiency of load transfer and reduce differential settlements, but the mechanisms of load transfer are different depending on the types and numbers of the geosynthetic reinforcement. When one or two layers of geotextiles are used, the load transfer from soil to piles is mainly caused by the combination of soil arching effect and tension membrane effect, and the latter acts later. In the case of piled embankment reinforced by two layers of geogrids, the mechanism of stiffened load transfer platform works due to the interaction of reinforcement and the surrounding fill. The piled embankment with a single layer of geogrid acts between the above two cases. Because only the geosynthetic strip between adjacent piles is assumed to be effective in the load transfer, the tensile force is overestimated in the conventional design methods.",
        "keywords": [
            "Geosynthetic reinforcement",
            "Model test",
            "Piled embankment",
            "Soil arching effect",
            "Tension membrane effect"
        ],
        "venue": "Yantu Gongcheng Xuebao/Chinese Journal of Geotechnical Engineering",
        "year": 2012,
        "id": "vAddftfx"
    },
    "rOcXA3wX": {
        "authors": [
            {
                "name": "Kang Fei",
                "org": "Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering"
            },
            {
                "name": "Junjun Wang",
                "org": "Institute of Geotechnical Engineering"
            },
            {
                "name": "Yi Chen",
                "org": "Institute of Geotechnical Engineering"
            }
        ],
        "title": "A three dimensional simplified method for analysis of soil arching effect in the pile-supported embankments",
        "abstract": "To improve the understanding of the soil aching effect in the embankment fill, a series of model tests and finite element analysis were carried out. It is found that for low fill height relative to the net pile spacing, H/(s-a)\u22641, the failure surface is vertical or slightly inclined which starts from the pile edge and goes through the whole fill height. For H/(s-a)\u22651.5, the developed bulb shaped rupture surface is located near the pile head and can be approximated as a logarithmic spiral surface. By using the failure surface shape determined from the model test and FEM analyses, a three dimensional simplified method to evaluate the soil arching effect was proposed. The computed results were compared with FEM results and the experimental data collected from literatures, it is found that the present simplified method can predict reliable results.",
        "keywords": [
            "Failure modes",
            "Finite element method",
            "Pile-supported embankment",
            "Soil arching effect"
        ],
        "venue": "Tumu Jianzhu yu Huanjing Gongcheng/Journal of Civil, Architectural and Environmental Engineering",
        "year": 2012,
        "id": "rOcXA3wX"
    },
    "odIERzVS": {
        "authors": [
            {
                "name": "Kang Fei",
                "org": "Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering"
            },
            {
                "name": "Jun-Jun Wang",
                "org": "Institute of Geotechnical Engineering"
            },
            {
                "name": "Yi Chen",
                "org": "Institute of Geotechnical Engineering"
            }
        ],
        "title": "A simplified method for analyzing soil arching effect in pile-supported embankments",
        "abstract": "To improve the understanding of the soil aching effect in the embankment fill, a parametrical study using finite element method is performed. In the analysis, the pile spacing, the fill height and the friction angle of embankment fill were varied. It is found that for low fill height relative to the net pile spacing, H/(s-a)\u22641, the failure surface is vertical or slightly inclined which starts from the pile edge and goes through the whole fill height. For H/(s-a)\u22651.5, the developed failure surface is similar to that assumed in the Terzaghi's bearing capacity theory; there are triangular elastic zone, radial shear zone and passive zone in the embankment fill. By using the failure surface shape determined from the FEM, a two-dimensional simplified method to evaluate the soil arching effect is proposed. The computed stress reduction ratios are compared with FEM results and the experimental data collected from literatures; it is found that the present simplified method can predict reliable results.",
        "keywords": [
            "Failure mode",
            "Finite elements",
            "Pile-supported embankment",
            "Soil arching effect",
            "Stress reduction ratio"
        ],
        "venue": "Yantu Lixue/Rock and Soil Mechanics",
        "year": 2012,
        "id": "odIERzVS"
    },
    "0q9aGtfE": {
        "authors": [
            {
                "name": "Kang Fei",
                "org": "Institute of Geotechnical Engineering"
            },
            {
                "name": "Jun-Jun Wang",
                "org": "Institute of Geotechnical Engineering"
            },
            {
                "name": "Yi Chen",
                "org": "Institute of Geotechnical Engineering"
            }
        ],
        "title": "Experimental and numerical studies of soil arching in piled embankment",
        "abstract": "In order to improve the understanding of soil arching effect in the piled embankment, a series of three-dimensional model tests were carried out. The stress reduction ratio and the vertical stress distribution in the embankment fill were studied in detail. Based on the measured and the computed results, the applicability of Terzaghi method and Hewlett & Randolph method were verified. Three-dimensional finite element analysis was also performed in this research; the computed orientation of maximum principal stresses, the stress level and the settlement pattern were analyzed in detail. Based on the test and numerical results, it is found that the value of stress reduction ratio computed by Terzaghi method is closed to that of Hewlett & Randolph method; but the vertical stress distributions of the two methods are different considerably. If the failure surface observed from the numerical result is used, the prediction of vertical stresses using Terzaghi's method is found to be coincident with the measured value.",
        "keywords": [
            "Finite elements",
            "Model test",
            "Piled embankment",
            "Soil arching effect"
        ],
        "venue": "Yantu Lixue/Rock and Soil Mechanics",
        "year": 2011,
        "id": "0q9aGtfE"
    },
    "twbagzDp": {
        "id": "twbagzDp",
        "title": "Cultivating Transferrable Skills in Engineering Students:A Case Study of Chemical Engineering Programs in the Developed Country",
        "abstract": "The present paper is a detailed discussion on talent training in higher education institutions.The paper maintains that cultivation of knowledge-based skills is merely one of the tasks of higher education,whose importance shall not be so exaggerated that the development of transferrable skills in students is ignored.Generally speaking,transferrable skills needed by engineering students fall into six categories,namely,communication,teamwork,problem-solving,IT,management and personality.When developing transferrable skills in chemical engineering majors,special emphasis should be laid upon the cultivation of students' teamwork skills,comprehension ability,cross-disciplinary knowledge,professional ethics,leadership qualities and managerial competence.",
        "keywords": [
            "transferrable skills",
            "engineering students",
            "chemical engineering programs",
            "higher education"
        ],
        "authors": [
            {
                "name": "Wang Hui",
                "org": ""
            },
            {
                "name": "Zhou Tao",
                "org": ""
            }
        ],
        "venue": "Modern University Education",
        "year": 2011
    },
    "NEpPpV9l": {
        "id": "NEpPpV9l",
        "title": "Development of International Education in Australia: Implications for China",
        "abstract": "Against the background of economic globalization and information society,international education has turned into a worldwide trend nowadays,and exporting education services has become an important means for major developed countries to earn foreign currency.In recent years,international education has developed into a rapidly growing industry in Australia,which is now one of the biggest education-exporting countries in the world.The present paper is to identify and analyze those major strategies adopted in Australia to promote the development of international education,such as,the use of legislative instruments,cooperation with international organizations or agencies,establishment of a comprehensive quality assurance system,expansion of international student enrollment,as well as internationalization of the curriculum.We should draw lessons from the Australian experience to facilitate the development of international education in China.",
        "keywords": [
            "quality assurance",
            "international education",
            "Australia"
        ],
        "authors": [
            {
                "name": "Kong Jiangrong",
                "org": ""
            },
            {
                "name": "Zhou Tao",
                "org": ""
            },
            {
                "name": "Wang Hui",
                "org": ""
            }
        ],
        "venue": "Modern University Education",
        "year": 2012
    },
    "1WRuRbvP": {
        "id": "1WRuRbvP",
        "title": "Whether Syndrome Differentiation Affects Treatment Result: Study Protocol of MaZiRenWan () for Functional Constipation in A Randomized Controlled Trial.",
        "abstract": "This trial is designed to evaluate the effectiveness of these three interventions for FC patients with the CM syndrome of excessive heat, and to determine the change of CM syndrome and the progress of disease during the treatment course. The results are important to explore whether syndrome differentiation is important for the therapeutic effect of a formula on a disease. [Trial registration: Chinese Clinical Trial Registry (Reg No. ChiCTR-TRC-13003742); protocol version: MZRW/NSFC-81173363 (2015.05.04)].",
        "keywords": [
            "Chinese herbal medicine",
            "MaZiRenWan",
            "functional constipation",
            "randomized controlled trial",
            "syndrome differentiation"
        ],
        "authors": [
            {
                "name": "Chung-Wah Cheng",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China."
            },
            {
                "name": "Li Zhang",
                "org": "Department of Clinical Pharmacology, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, China."
            },
            {
                "name": "Chen Zhao",
                "org": "Department of Clinical Pharmacology, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, China."
            },
            {
                "name": "Linda Ld Zhong",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China."
            },
            {
                "name": "Li-Jie Shi",
                "org": "Department of Gastroenterology, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China."
            },
            {
                "name": "Liang Dai",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China."
            },
            {
                "name": "Rui Zheng",
                "org": "Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China."
            },
            {
                "name": "Jing Chen",
                "org": "Department of Health Care, Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China."
            },
            {
                "name": "Ge Li",
                "org": "School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China."
            },
            {
                "name": "Jing-Bo Zhai",
                "org": "Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China."
            },
            {
                "name": "Wai Kun",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China."
            },
            {
                "name": "Ai-Ping Lu",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China."
            },
            {
                "name": "Hong-Cai Shang",
                "org": "Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China."
            },
            {
                "name": "Zhao-Xiang Bian",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. bzxiang@hkbu.edu.hk."
            }
        ],
        "venue": "Chinese journal of integrative medicine",
        "year": 2018
    },
    "nq32EqZg": {
        "id": "nq32EqZg",
        "title": "Whether Syndrome Differentiation Affects Treatment Result: Study Protocol of MaZiRenWan (\u9ebb\u5b50\u4ec1\u4e38) for Functional Constipation in A Randomized Controlled Trial",
        "abstract": "BackgroundSyndrome is one of the most important concepts in Chinese medicine (CM) theory. However, it was not well accounted in most of randomized controlled trials (RCTs).",
        "keywords": "",
        "authors": [
            {
                "name": "Chung-wah Cheng",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            },
            {
                "name": "Li Zhang",
                "org": "Department of Clinical Pharmacology, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"
            },
            {
                "name": "Chen Zhao",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            },
            {
                "name": "Linda Ld Zhong",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            },
            {
                "name": "Li-jie Shi",
                "org": "Department of Gastroenterology, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"
            },
            {
                "name": "Liang Dai",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            },
            {
                "name": "Rui Zheng",
                "org": "Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China"
            },
            {
                "name": "Jing Chen",
                "org": "Department of Health Care, Baokang Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China"
            },
            {
                "name": "Ge Li",
                "org": "School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China"
            },
            {
                "name": "Jing-bo Zhai",
                "org": "Research Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China"
            },
            {
                "name": "Wai Kun",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            },
            {
                "name": "Ai-ping Lu",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            },
            {
                "name": "Hong-cai Shang",
                "org": "Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China"
            },
            {
                "name": "Zhao-xiang Bian",
                "org": "Hong Kong Chinese Medicine Clinical Study Centre, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"
            }
        ],
        "venue": "Chinese Journal of Integrative Medicine",
        "year": 2019
    },
    "HrM4VAyn": {
        "authors": [
            {
                "name": "Yuhan Sun",
                "org": ""
            },
            {
                "name": "Yuyao Zhang",
                "org": ""
            },
            {
                "name": "Cunquan Yuan",
                "org": ""
            },
            {
                "name": "Qing Yang",
                "org": ""
            },
            {
                "name": "Cui Long",
                "org": ""
            },
            {
                "name": "Yun Li",
                "org": ""
            },
            {
                "name": "Minsheng Yang",
                "org": ""
            }
        ],
        "title": "Assessment of genetic diversity and variation of acer mono max seedlings after spaceflight",
        "abstract": "Genetic diversity and variation of Acer Mono Maxim seedlings sampled from space-mutated (sm) populations were compared to seedlings from parallel control (ck) ones using molecular markers. RAMP analysis showed that the percentage of polymorphic band, Shannon diversity index and Nei\u2019s gene diversity index of the space-mutated populations were higher than those of the control ones, which indicated that genetic variation increased after spaceflight in populations of Acer Mono Maxim. By using un-weighted pair group method with arithmetic mean (UPGMA) method, three space-mutated repeats (populations) were clustered together, and control groups clustered separately, which further indicated that there was difference between the space-mutated ones and the control ones, which may be caused by space mutation. Further analysis of genomic inconsistency between the root and leaf samples from the same tree showed that a total variation rate of 6.3% and 1.7% were obtained in ten space-mutated individuals by using RAMP and SSR markers, respectively, however, the variation rate was zero in control ones. It provided that space mutation may be caused the individual variation of Acer Mono Maxim.",
        "keywords": [
            "Acer Mono Maxim",
            "Genetic variation",
            "Space mutation"
        ],
        "venue": "Pakistan Journal of Botany",
        "year": 2015,
        "id": "HrM4VAyn"
    },
    "KK4fH1gL": {
        "authors": [
            {
                "name": "Ke-Tao Ma",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Li Li",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Bing-Cai Guan",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Xin-Zhi Li",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "He Zhu",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Lei Zhao",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Jun-Qiang Si",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            }
        ],
        "title": "Effects of acute hypoxia on the electrophysiological properties of vascular smooth muscle cells of mesenteric artery in guinea pig",
        "keywords": [
            "Cell hypoxia",
            "Electrophysiology",
            "Mesenteric arteries",
            "Myocytes,smooth muscle"
        ],
        "venue": "National Medical Journal of China",
        "year": 2011,
        "id": "KK4fH1gL"
    },
    "dsXQ5b2p": {
        "authors": [
            {
                "name": "Ke-Tao Ma",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Xin-Zhi Li",
                "org": "Department of Pathophysiology"
            },
            {
                "name": "L. Li",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Xue-Wei Jiang",
                "org": "Department of Physiology"
            },
            {
                "name": "Xin-Yan Chen",
                "org": "Department of Physiology"
            },
            {
                "name": "Wei-Dong Liu",
                "org": "Department of Physiology"
            },
            {
                "name": "Lei Zhao",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Zhong-Shuang Zhang",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Jun-Qiang Si",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            }
        ],
        "title": "Role of gap junctions in the contractile response to agonists in the mesenteric artery of spontaneously hypertensive rats",
        "keywords": [
            "connexin",
            "gap junction",
            "mesenteric artery",
            "spontaneously hypertensive rats",
            "vascular smooth muscle cell",
            "whole-cell patch clamping"
        ],
        "venue": "Hypertension Research",
        "year": 2014,
        "id": "dsXQ5b2p"
    },
    "P7OO5d8R": {
        "authors": [
            {
                "name": "Xin-Zhi Li",
                "org": "Key Laboratory of Xinjiang Endemic and Ethnic Diseases"
            },
            {
                "name": "Jun-Qiang Si",
                "org": "Department of Physiology"
            },
            {
                "name": "Li Li",
                "org": "Department of Physiology"
            },
            {
                "name": "Zheng-Jiang Liu",
                "org": "Department of Physiology"
            },
            {
                "name": "Lei Zhao",
                "org": "Department of Physiology"
            },
            {
                "name": "Ke-Tao Ma",
                "org": "Department of Physiology"
            }
        ],
        "title": "Inhibitory effect of 18\u03b2-glycyrrhetinic acid on gap junction of vascular smooth muscle cells in guinea pig",
        "keywords": [
            "18\u03b2-glycyrrhetinic acid",
            "Arteriole",
            "Gap junction",
            "Patch clamp",
            "Smooth muscle cell"
        ],
        "venue": "Journal of Jilin University Medicine Edition",
        "year": 2011,
        "id": "P7OO5d8R"
    },
    "389IH1DJ": {
        "id": "389IH1DJ",
        "title": "Abstract 4073: The potential role of oral mucosa stem cell altruistic behavior as the initiating event of malignant transformation",
        "abstract": "Oral cancer presents a major health burden across the globe, specially in developing countries. Kamrup, a district of India, where the KaviKrishna laboratory is located has the highest incidence of oral cancer in the entire world. The mechanism of oral cancer carcinogenesis process is not clearly known. Previous studies indicate the potential role of HPV-16 virus as well as tobacco consumption as major contributing factors of oral cancer. In mouse, the carcinogen agent 4-NQO was found to induce oral cancer having similar phenotype as human oral mucosa cancer. 4-NQO may exert tobacco like oxidative stress toxicity to oral mucosa. Hence, developing both in vitro and in vivo models of HPV-16 and 4-NQO mediated oral carcinogenesis might help to understand the initiating event of oral carcinogenesis. In this study, we propose that oral mucosa stem cells (OMSCs) could be the target of HPV-16, and 4-NQO induced carcinogensis. Thus, in vitro treatment of oral mucosa cells of healthy human volunteers with HPV-16 protein E6, and 4-NQO led to expansion of CD271+ cells, which are enriched in OMSCs. Importantly, the expanded CD271+ cells exhibited high HIF-2alpha, low p53, and high glutathione secretion, a phenotype of stem cell altruism that we recently described in human embryonic stem cells (Das B et al. Stem Cells, 2012). In human ES cells, the altruistic reprogramming served as an initiating event of malignant transformation by altering p53/MDM2 oscillation, in an abnormal state of low p53 and high MDM2. Therefore, we performed a complete evaluation of E6 protein and 4-NQO treated CD271+ oral mucosa cells for altruistic behavior, including low p53 and high MDM2 state. For this purpose, the carcinogen treated oral mucosa cells were subjected to immunomagnetic sorting for CD271+ cells. We found that post-carcinogen treated CD271+ cells exhibited in vitro self-renewal activity, high GSH secretion, and importantly activation of a HIF-2alpha/MYC co-operation. ChiP assay revealed the MYC binding to HIF-2alpha, and Sox-2, an stemness associated transcription factor. Importantly, HIF-2alpha was important for the reversible but prolonged suppression of p53 for more than two weeks. We also found that the high HIF-2alpha and low p53 expressing CD271+ cells could be enriched in a ABCG2+ population. Thus, we were able to enrich a CD271+/ABCG2+ cell population in oral mucosa cells of both human and mouse. Based on these findings we propose to use HPV-16 and 4NQO derived carcinogenesis models to study the potential role of altruistic reprogramming in the malignant transformation of oral mucosa stem cells to oral cancer stem cell like cells. Our study may unravel a novel mechanism of malignant transformation, the failure of altruistic stem cells to sacrifice its fitness (altruism) as a potential initiating event of malignant transformation of stem cells to cancer stem cells.   Citation Format:  Sukanya Gayan, Hong Li, Rashmi Bhuyan, Sora Sandhya, Joyeeta Talukdar, Bidisha Pal, Jaishree Garhyan, Wael Tasabehji, Manaf Muhammad Alkurdi, Heidar Zohrehei, Seema Bhuyan, Anupam Sarma, Gayatri Gogoi, A.C. Kataki, Rakesh Bhatnagar, Debabrata Baishya, Bikul Das. The potential role of oral mucosa stem cell altruistic behavior as the initiating event of malignant transformation. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4073.",
        "keywords": "",
        "authors": [
            {
                "name": "Sukanya Gayan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Hong Li",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Rashmi Bhuyan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Sora Sandhya",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Joyeeta Talukdar",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Bidisha Pal",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Jaishree Garhyan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Wael Tasabehji",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Manaf Muhammad Alkurdi",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Heidar Zohrehei",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Seema Bhuyan",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Anupam Sarma",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Gayatri Gogoi",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "AmalChandra Kataki",
                "org": ""
            },
            {
                "name": "Rakesh Bhatnagar",
                "org": "Jawaharlal Nehru University, New Delhi, India;"
            },
            {
                "name": "Debabrata Baishya",
                "org": "Gauhati University, Guwahati, India."
            }
        ],
        "venue": "Cancer Research",
        "year": 2016
    },
    "RydrZ33b": {
        "id": "RydrZ33b",
        "title": "Abstract PR14: HIF-2alpha regulates self-renewal of MYC dependent cancer stem cells",
        "abstract": "Numerous studies report that both hematopoietic and some solid tumors are organized in a hierarchical manner where tumor growth is driven by a small subset of cancer stem cells (CSCs). However, the distinct molecular identity of CSC versus non-CSC is not yet clearly known, which limit our understanding on how CSC self-renewal pathways operate to drive tumorigenicity. Here, we report that MYC and HIF-2alpha co-operate to maintain distinct identity and self-renewal capacity of CSCs. In a transgenic mouse model of conditional MYC driven thymic lymphoma, we identified a Sca-1+ cell population that showed tumor stemness (self-renewal and undifferentiation state) phenotype, including high expression of Nanog, Sox2 and HIF-2alpha. When injected to congenic mice, Sca-1+ cells but not Sca-1- cells exhibited hierarchical organization including self-renewal capacity. ChIP assay revealed direct MYC binding of HIF-2alpha promoter region in Sca-1+ but not in the Sca-1- cells. Inhibition of HIF-2alpha led to increase ROS generation, decrease of GSH synthesis, differentiation, and loss of self-renewal capacity of Sca-1+ cells. In contrast, inhibition of HIF-2alpha had no phenotypic effect on Sca-1- cells. Thus, we have identified a distinct CSC population in MYC dependent cancer cells, where MYC preferentially binds to HIF-2alpha to maintain self-renewal capacity.   Citation Format:  Bikul Das, Bikul Das, Hong Li, Hong Li, Rashmi Bhuyan, Dean W. Felsher. HIF-2alpha regulates self-renewal of MYC dependent cancer stem cells. [abstract]. In: Proceedings of the AACR Special Conference on Myc: From Biology to Therapy; Jan 7-10, 2015; La Jolla, CA. Philadelphia (PA): AACR; Mol Cancer Res 2015;13(10 Suppl):Abstract nr PR14.",
        "keywords": "",
        "authors": [
            {
                "name": "Bikul Das",
                "org": "Stanford University School of Medicine, Stanford, CA,"
            },
            {
                "name": "Hong Li",
                "org": "Stanford University School of Medicine, Stanford, CA,"
            },
            {
                "name": "Rashmi Bhuyan",
                "org": "Stanford University School of Medicine, Stanford, CA,"
            },
            {
                "name": "Dean W. Felsher",
                "org": "Stanford University School of Medicine, Stanford, CA,"
            }
        ],
        "venue": "Molecular Cancer Research",
        "year": 2015
    },
    "wNsM33Hm": {
        "id": "wNsM33Hm",
        "title": "Abstract 935: Oral cancer cells may hijack stem cell altruism to survive during extreme hypoxia, and exposure to chemotherapeutic drugs",
        "abstract": "The mechanism of tumor hypoxia induced reprogramming of cancer cells are not understood well. Hypoxia might activate evolutionary preserved cellular defense mechanism that could contribute to tumor progression and metastasis. We recently described that during hypoxia/oxidative stress, human embryonic stem cells (hES) exhibit an altruistic defense mechanism, where a few cells reprogram to a highly undifferentiated state, and secrete glutathione to protect rest of the community of cells from oxidative stress induced DNA damage (Das B et al, Stem Cells, 2012). The altruistic stem cells phenotype exhibited high HIF-2alpha and low p53 activity. After a few weeks, the reprogrammed cells, although highly fit to survives, underwent spontaneous apoptosis/differentiation by re-activating the p53/MDM2 oscillation. Thus, the reprogrammed cells sacrificed its own fitness to enhance the fitness of the rest of the community, an altruistic behavior (Das B et al. Stem Cells, 2012). Here, we investigated the potential hijacking of the altruistic defense mechanism by oral cancer cells during exposure to hypoxia. We exposed the four oral cancer cell lines SCC-25, SCC-15, SCC-9 and SCC-5 to extreme hypoxia followed by re-oxygenation for 72 hours. We found that while majority of cancer cells underwent apoptosis, a few cancer cell lines survived, exhibited side-population (SP) phenotype, high level of HIF-2alpha, Nanog, Sox-2 and MYC. The SP cells exhibited migratory activity, as well as high tumorigenic and metastatic activity in NOD/SCID mice. ChIP assay indicated that HIF-2alhpa interact with MYC and NOTCH1. The conditioned media of SP cells exhibited high level of glutathione, and ability to protect non-SP cells from cisplatin-induced toxicity. These results indicate that HIF-2alpha and MYC may cooperate to reprogram a few oral cancer cells to altruistic stemness phenotype. The altruistic phenotype that exhibited cytoprotective activity against cisplatin mediated toxicity. Thus, similar to bacteria, where altruistic biofilm exhibit novel drug resistance mechanism, stem cell altruism may serve as a novel drug resistance mechanism in oral cancer.   Citation Format:  Rashmi Bhuyan, Hong Li, Sukanya Gayan, Bidisha Pal, Reza Bayat-Mokhtari, Jyotirmoy Phukan, Debabrata Baishya, Anupam Sarma, Joyeeta Talukdar, Manaf Muhammad Alkurdi, Wael Tasabehji, Seema Bhuyan, Gayatri Gogoi, Ista Pulu, Herman Yeger, Bikul Das. Oral cancer cells may hijack stem cell altruism to survive during extreme hypoxia, and exposure to chemotherapeutic drugs. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 935.",
        "keywords": "",
        "authors": [
            {
                "name": "Rashmi Bhuyan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Hong Li",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Sukanya Gayan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Bidisha Pal",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Reza Bayat-Mokhtari",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Jyotirmoy Phukan",
                "org": "Guwahati Medical College, Guwahati, India;"
            },
            {
                "name": "Debabrata Baishya",
                "org": "Gauhati University, Guwahati, India;"
            },
            {
                "name": "Anupam Sarma",
                "org": "B Borooah Cancer Institute, Guwahati, India;"
            },
            {
                "name": "Joyeeta Talukdar",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Manaf Muhammad Alkurdi",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Wael Tasabehji",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Seema Bhuyan",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Gayatri Gogoi",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Ista Pulu",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Herman Yeger",
                "org": "Hospital for Sick Children, Toronto, Ontario, Canada."
            }
        ],
        "venue": "Cancer Research",
        "year": 2016
    },
    "8xI4sAcM": {
        "id": "8xI4sAcM",
        "title": "Abstract 2681: Oral micro biome enhances stemness in oral cancer cells by activating Toll like receptor signaling",
        "abstract": "Background: The resistance and progression of cancers after chemotherapy to invasive and metastatic stages accounts for the overwhelming majority of cancer deaths. Recent studies suggest, microbiomes can induce a cascade of host events to either support or inhibit tumor growth. Specially, in oral cancer, chemotherapy treatment may alter the oral microbial flora, which may favor or inhibit tumor growth. Hence, it is importantl to develop novel experimental approaches to study the role of oral microbial flora in oral cancer stemness (self-renewal and undifferntiated state of cancer stem cells). Importantly, patients in developing area, including Assam, where KaviKrishna laboratory is located, may have distinct oral microbial flora that could favor oral cancer growth. Hence, it is important to include patients from developing countries for such studies. Our previous research showed that chemotherapy ehances stemenss in many cancer cell types, including oral squamous cell carcinoma cell line SSC-25. The stemness switch is characterized by enhanced expression of stemness associated genes including Nanog, Lin28A/B, Oct-4, MYC, HIF-2alpha and inflammation associated genes including Toll like receptor (TLR) 2/4. Here we investigated the role of oral microbiomes in the TLR mediated stemness switch of oral cancer cells.  Methods: SCC-25 oral cancer cell line was treated with bacterial product lipopoly saccharide (LPS), and the stemness switch evaluated by isolation of ABCG2+ cells and expression of stemness associated genes by these cells. Capacity of interaction of tumor stromal cells with mesenchymal stem cells was also evaluated. Additionally, we obtained sputum from oral cancer subjects undergoing chemotherapy. The patients were from the Kamrup district of Assam, where KaviKrishna laboratory is located. The sputum was processed and then added to the culture medium of SCC-25 cells. These post-sputum treated SCC-25 cells were subjected to phenotypic stemness switch analysis.  Results: We found, LPS and sputum treatment led to the enhanced stemness of ABCG2+ cells, including the high expression of TLR2/4, MYC, Nanog, Sox-2, and HIF-2alpha. Importantly, sputum derived from oral cancer subjects under remission showed inhibitory activity on ABCG2+ cell self-renewal. In contrast, sputum obtained from oral cancer subjects with relapse showed enhanced stemness of ABCG2+ cells, and also increased tumorigenic potential. The post-sputum treated ABCG2+ cells exhibited high expression of TLR2/4 and associated increase of HIF-2alpha and MYC transcriptional activity. The sputum treated with broad spectrum antibiotic ciprofloxacin did not enhance the stemness and TLR2/4 signaling of SCC-25 cells.  Conclusion: These results indicate that oral microbiomes may differentially influence the stemness of oral cancer cells. We also conclude that live bacteria present in the sputum may be required to enhance stemness in a TLR2/4 dependent manner.   Note:  This abstract was not presented at the meeting.   Citation Format:  Joyeeta Talukdar, Rashmi Bhuyan, Bidisha Pal, Sorra Sandhya, Hong Li, Seema Bhuyan, Sukanya Garhyan, Debabrat Baishya, Anupam Sarma, Jyotirmoy Phukan, Amal Kataki, Bikul Das. Oral micro biome enhances stemness in oral cancer cells by activating Toll like receptor signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 2681. doi:10.1158/1538-7445.AM2017-2681",
        "keywords": "",
        "authors": [
            {
                "name": "Joyeeta Talukdar",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, IIT, Guwahati, India;"
            },
            {
                "name": "Rashmi Bhuyan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Bidisha Pal",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Sorra Sandhya",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, IIT, Guwahati, India;"
            },
            {
                "name": "Hong Li",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Seema Bhuyan",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, IIT, Guwahati, India;"
            },
            {
                "name": "Sukanya Garhyan",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, IIT, Guwahati, India;"
            },
            {
                "name": "Debabrat Baishya",
                "org": "Gauhati University, Guwahati, India;"
            },
            {
                "name": "Anupam Sarma",
                "org": "B Borooah Cancer Institue, Guwahati, India."
            },
            {
                "name": "Jyotirmoy Phukan",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, IIT, Guwahati, India;"
            },
            {
                "name": "Amal C Kataki",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2017
    },
    "yZjI0CUg": {
        "id": "yZjI0CUg",
        "title": "Abstract 251: Stem cell altruism may serve as a novel drug resistance mechanism in oral cancer",
        "abstract": "Background: The mechanism of oral squamous cell carcinoma resistance to platinum-based chemotherapy is not clearly known. Previous studies indicated that glutathione (GSH), a cellular antioxidant may detoxify cisplatinum (CDDP), a commonly used chemotherapy agent in oral cancer. Our previous research in human embryonic stem cells (hESCs) indicated the altruistic behavior of ABCG2+ hESCs that secrete high level of GSH to protect other hESCs exposed to oxidative stress (Das B et al. Stem Cells, 2012). Here we investigated if CDDP exposure lead to altruistic stem cell reprogramming of ABCG2+ oral squamous cell carcinoma cells and subsequent GSH-mediated resistance against CDDP. Methods: Two oral squamous cell cancer cell lines SCC-25 and SCC-15 were treated with 3-10 uM CDDP for three-days, and then subjected to flow cytometry and immunomagnetic sorting based evaluation of ABCG2+ cells. The conditioned media (CM) obtained from ABCG2+ cells were examined for GSH content. The CM treated cancer cell lines were examined for resistance against CDDP toxicity. Next, the post-CDDP treated ABCG2+ cells were examined for enhanced stemness phenotype that corresponds to altruistic stem cell phenotype (Das B et al, Stem Cells 2012). Results: We found that CDDP treatment increases the ABCG2+ self-renewal capacity of SCC-25 and SCC-15 cells as measured by serial transplantation assay. The CM of the post-CDDP treated cells exhibited high level of GSH. When the SCC-15 and SCC-25 cells were treated with CM plus CDDP, the cancer cells exhibited 10-15-fold increase in resistance against CDDP toxicity. Next, the post-CDDP treated SCC-25 and SCC-15 cells exhibited enhanced stemness reprogramming phenotype characterized by very high HIF-2alpha, Sox-2 and Nanog transcriptional activity. Furthemore, we found increased expression of EMT (epithelial mesenchymal transition) marker expression including Snail, Twist and vimentin as evaluated by flow cytometry. siRNA HIF-2alpha treatment led to marked loss in the in vivo self-renewal capacity of ABCG2+ SCC-25 and SCC-15 cells. We then noted that post-CDDP ABCG2+ cells exhibited reversible state, as after two weeks of culture, most of the cells either differentiated or underwent apoptosis. Conclusions: These results indicate that oral cancer cells exhibit altruistic defense mechanism to resist the toxicity of CDDP. The altruistic defense mechanism involved high secretion of GSH. Thus, we suggest that similar to bacterial altruism as a mechanism of drug resistance, stem cell altruism may also serve as a novel mechanism of drug resistance in cancer.   Citation Format:  Bidisha Pal, Reza Bayat-Mokhtari, Hong Li, Rashmi Bhuyan, Joyeeta Talukdar, Sora Sandhya, Anupam Sarma, Wael Tasabehji, Seema Bhuyan, Sukanya Gayan, Amal Ch Kataki, Debabrata Baishya, Herman Yeger, Dean W. Felsher, Bikul Das. Stem cell altruism may serve as a novel drug resistance mechanism in oral cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 251.",
        "keywords": "",
        "authors": [
            {
                "name": "Bidisha Pal",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Reza Bayat-Mokhtari",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Hong Li",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Rashmi Bhuyan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Joyeeta Talukdar",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Sora Sandhya",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Anupam Sarma",
                "org": "B Borooah Cancer Institute, Guwahati, India;"
            },
            {
                "name": "Wael Tasabehji",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Seema Bhuyan",
                "org": "KaviKrishna Laboratory, Guwahati Biotech Park, Guwahati, India;"
            },
            {
                "name": "Sukanya Gayan",
                "org": "Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Amal C Kataki",
                "org": "B Borooah Cancer Institute, Guwahati, India;"
            },
            {
                "name": "Debabrata Baishya",
                "org": "Gauhati University, Guwahati, India;"
            },
            {
                "name": "Herman Yeger",
                "org": "Hospital for Sick Children, Toronto, Ontario, Canada;"
            },
            {
                "name": "Dean W. Felsher",
                "org": "Stanford University School of Medicine, Stanford, CA."
            },
            {
                "name": "Bikul Das",
                "org": "Stanford University School of Medicine, Stanford, CA."
            }
        ],
        "venue": "Cancer Research",
        "year": 2016
    },
    "TlVADwz1": {
        "id": "TlVADwz1",
        "title": "Abstract 1529: MYC and HIF-2alpha cooperates in oral squamous carcinoma cell self-renewal during hypoxia",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hong li",
                "org": "the forsyth institute"
            },
            {
                "name": "joyeeta talukdar",
                "org": ""
            },
            {
                "name": "sora sandhya",
                "org": ""
            },
            {
                "name": "seema bhuyan",
                "org": ""
            },
            {
                "name": "sukanya gayan",
                "org": "the forsyth institute"
            },
            {
                "name": "a k sarma",
                "org": ""
            },
            {
                "name": "reza bayat mokhtari",
                "org": ""
            },
            {
                "name": "dean w felsher",
                "org": "stanford university school of medicine"
            },
            {
                "name": "herman yeger",
                "org": ""
            },
            {
                "name": "bikul das",
                "org": "the forsyth institute"
            }
        ],
        "venue": "Cancer Research",
        "year": 2015
    },
    "pZXcdW3J": {
        "id": "pZXcdW3J",
        "title": "MYC Regulates the HIF2\u03b1 Stemness Pathway via Nanog and Sox2 to Maintain Self-Renewal in Cancer Stem Cells versus Non-Stem Cancer Cells.",
        "abstract": "Cancer stem cells (CSC) maintain both undifferentiated self-renewing CSCs and differentiated, non-self-renewing non-CSCs through cellular division. However, molecular mechanisms that maintain self-renewal in CSCs versus non-CSCs are not yet clear. Here, we report that in a transgenic mouse model of MYC-induced T cell leukemia, MYC maintains self-renewal in Sca1+ CSCs versus Sca-1- non-CSCs. MYC preferentially bound to the promoter and activated HIF-2\u03b1 in Sca-1+ cells only. Further, the reprogramming factors Nanog and Sox2 facilitated MYC regulation of HIF-2\u03b1 in Sca-1+ versus Sca-1- cells. Reduced expression of HIF-2\u03b1 inhibited the self-renewal of Sca-1+ cells; this effect was blocked through suppression of reactive oxygen species (ROS) by N-acetyl cysteine (NAC) or the knock down of p53, Nanog or Sox2. Similar results were seen in ABCG2+ CSCs versus ABCG2- non-CSCs from primary human T cell lymphoma. Thus, MYC maintains self-renewal exclusively in CSCs by selectively binding to the promoter and activating the HIF-2\u03b1 stemness pathway. Identification of this stemness pathway as a unique CSC determinant may have significant therapeutic implications.",
        "keywords": "",
        "authors": [
            {
                "name": "Bikul Das",
                "org": "Dept of Cancer and Stem Cell Biology, KaviKrishna Laboratory,Indian Institute of Technology Complex."
            },
            {
                "name": "Bidisha Pal",
                "org": "Dept of Cancer and Stem Cell Biology, Thoreau Laboratory for Global Health."
            },
            {
                "name": "Rashmi Bhuyan",
                "org": "Dept of Cancer and Stem Cell Biology, KaviKrishna Laboratory, Indian Institute of Technology Complex."
            },
            {
                "name": "Hong Li",
                "org": "Dept of Immunology and Infectious Diseases, Forsyth Institute."
            },
            {
                "name": "Anupam Sarma",
                "org": "KaviKrishna Laboratory."
            },
            {
                "name": "Sukanya Gayan",
                "org": "Dept of Cancer and Stem Cell Biology, KaviKrishna Laboratory, Indian Institute of Technology Complex."
            },
            {
                "name": "Joyeeta Talukdar",
                "org": "Dept of Cancer and Stem Cell Biology, KaviKrishna Laboratory, Indian Institute of Technology Complex."
            },
            {
                "name": "Sorra Sandhya",
                "org": "Animal cell Culture, KaviKrishna Laboratory."
            },
            {
                "name": "Seema Bhuyan",
                "org": "Dept of Cancer and Stem Cell Biology, KaviKrishna Laboratory,Indian Institute of Technology Complex."
            },
            {
                "name": "Gayatri Gogoi",
                "org": "KaviKrishna Laboratory."
            },
            {
                "name": "Arvin M Gouw",
                "org": "Medicine-Oncology, Stanford University."
            },
            {
                "name": "Debabrat Baishya",
                "org": "Department of Bioengineering and Technology, Gauhati University."
            },
            {
                "name": "Jason R Gotlib",
                "org": "Stanford University."
            },
            {
                "name": "Amal C Kataki",
                "org": "Department of Gynaecologic Oncology, Dr. B. Borooah Cancer Institute. Guwahati, Assam, India."
            },
            {
                "name": "Dean W Felsher",
                "org": "Dept of Medicine/ Oncology, Stanford University dfelsher@stanford.edu."
            }
        ],
        "venue": "Cancer research",
        "year": 2019
    },
    "jcPrSpkn": {
        "id": "jcPrSpkn",
        "title": "Abstract 920: Migratory cancer side population cells induces stem cell altruism in bone marrow mesenchymal stem cells to resist therapy, and enhance tumorigenic potential of non-tumorigenic cells",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Joyeeta Talukdar",
                "org": ""
            },
            {
                "name": "Rashmi Bhuyan",
                "org": ""
            },
            {
                "name": "Jaishree Garhyan",
                "org": ""
            },
            {
                "name": "Bidisha Pal",
                "org": ""
            },
            {
                "name": "Sora Sandhya",
                "org": ""
            },
            {
                "name": "Sukanya Gayan",
                "org": ""
            },
            {
                "name": "Anupam Sarma",
                "org": ""
            },
            {
                "name": "Reza Bayat-Mokhtari",
                "org": ""
            },
            {
                "name": "Hong Li",
                "org": ""
            },
            {
                "name": "Jyotirmoy Phukan",
                "org": ""
            },
            {
                "name": "Wael Tasabehji",
                "org": ""
            },
            {
                "name": "Seema Bhuyan",
                "org": ""
            },
            {
                "name": "Amal C Kataki",
                "org": ""
            },
            {
                "name": "Rika Tsuchida",
                "org": ""
            },
            {
                "name": "Herman Yeger",
                "org": ""
            },
            {
                "name": "Debabrata Baishya",
                "org": ""
            },
            {
                "name": "Bikul Das",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2016
    },
    "WmPXtmZi": {
        "id": "WmPXtmZi",
        "title": "Abstract 3903: Targeting oral cancer stem cells in the hypoxic niche by BCG infected mesenchymal stem cells",
        "abstract": "Background: Tumor hypoxia is a major contributing factor in cancer therapeutic failure. The microenvironment of hypoxia/oxidative stress may reprogram cancer cells to highly tumorigenic, metastatic, angiogenic and stem cell-like state. We have characterized in vitro and in vivo models of hypoxia-induced cancer cell reprogramming to cancer stem cell (CSCs) like cells including an immunocompetent model of oral cancer. These CSCs exhibit ABCG2 cell surface marker. Numerous approaches including targeted therapy using oncolytic virus and bacteria have been attempted to target cancer cells in their hypoxic niche without major therapeutic success. Major therapeutic challenges include the inaccessibility of hypoxic niche by therapy-agents and the poor replication of viruses or bacteria intracellular to hypoxic cancer cells. Furthermore, the immune privileged microenvironment of tumor hypoxia could pose a challenge to viral/bacterial-induced immunity against the tumor. In this context, here we have tested a novel stem cell-based approach to deliver BCG infected stem cells to the hypoxic core of tumors.  Methods: Human SCC-25 cell line-derived xenograft in NOD/SCID mice exhibit hypoxic zones, where ABCG2+ resides (1). SCC-25 tumor-bearing mice were injected i.v. with CD271+ bone marrow mesenchymal stem cells (BM-MSCs). We recently found that CD271+ BM-MSCs could be infected with M. tuberculosis. The BCG infected CD271+ BM-MSCs were injected to SCC-25 xenograft-bearing mice. The mice were sacrificed on day-20 of stem cell injection and then evaluated for the hypoxic CSCs. Next, we have developed a 4-NQO induced oral cancer cell line, which was injected orthotropic to the tongue of congenic mice. The mice developed tumors, which was hypoxic. In these tumor-bearing mice, BCG-infected murine CD271 BM-MSCs were injected i.v., and animals were monitored for four weeks for tumor growth. On day-20 of injection, mice were sacrificed, and the tumors were collected. In a control group, BCG alone was injected.  Results: In both the SCC-25 and an immunocompetent mouse model, we found that BCG or CD271+ BM-MSCs injection alone did not result in marked anti-tumor activity and or elimination of ABCG2+ cells from their hypoxic niche. In contrast, the injection of BCG infected CD271+ BM-MSCs led to marked reduction of tumor growth. Importantly, we observed marked replication of BCG intracellular to CSCs. These results indicate that CD271+ BM-MSCs facilitated the transfer of BCG to cancer cells residing in the hypoxic zone. Importantly, the transfer of BCG was seen more in the immunocompetent model, suggesting potential role of immune system.  Conclusions: Our findings indicate that hypoxic CSCs may be targeted by a few BCG infected CD271 BM-MSCs. We propose this could be a novel therapeutic approach to target drug resistance cancer stem cells residing in the hypoxic niche of tumors.1. Bhuyan R et al, Cancer Research, 2016; Volume 76, Issue 14 Supplement, pp. 935.   Note:  This abstract was not presented at the meeting.   Citation Format:  Bidisha Pal, Seema Bhuyan, Jaishree Garhyan, Hong Li, Rashmi Bhuyan, Herman Yeger, Bikul Das. Targeting oral cancer stem cells in the hypoxic niche by BCG infected mesenchymal stem cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 3903. doi:10.1158/1538-7445.AM2017-3903",
        "keywords": "",
        "authors": [
            {
                "name": "Bidisha Pal",
                "org": "The Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Seema Bhuyan",
                "org": ""
            },
            {
                "name": "Jaishree Garhyan",
                "org": ""
            },
            {
                "name": "Hong Li",
                "org": "The Forsyth Institute, Cambridge, MA;"
            },
            {
                "name": "Rashmi Bhuyan",
                "org": ""
            },
            {
                "name": "Herman Yeger",
                "org": "Hospital for Sick Childern, Toronto, Ontario, Canada."
            },
            {
                "name": "Bikul Das",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2017
    },
    "osEny9xZ": {
        "authors": [
            {
                "name": "Zhipeng Zhou",
                "org": "State Key Laboratory of Agrobiotechnology"
            },
            {
                "name": "Xiao Liu",
                "org": "State Key Laboratory of Agrobiotechnology"
            },
            {
                "name": "Qiwen Hu",
                "org": "Department of Microbiology"
            },
            {
                "name": "Ning Zhang",
                "org": "State Key Laboratory of Agrobiotechnology"
            },
            {
                "name": "Guangyan Sun",
                "org": "State Key Laboratory of Agrobiotechnology"
            },
            {
                "name": "Joonseok Cha",
                "org": "Department of Physiology"
            },
            {
                "name": "Ying Wang",
                "org": "State Key Laboratory of Agrobiotechnology"
            },
            {
                "name": "Yi Liu",
                "org": "Department of Physiology"
            },
            {
                "name": "Qun He",
                "org": "State Key Laboratory of Agrobiotechnology"
            }
        ],
        "title": "Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock",
        "abstract": "Rhythmic activation and repression of clock gene transcription is essential for the functions of eukaryotic circadian clocks. In the Neurospora circadian oscillator, frequency (frq) transcription requires the WHITE COLLAR (WC) complex. Here, we show that the transcriptional corepressor regulation of conidiation-1 (RCO-1) is essential for clock function by regulating frq transcription. In rco-1 mutants, both overt and molecular rhythms are abolished, frq mRNA levels are constantly high, and WC binding to the frq promoter is dramatically reduced. Surprisingly, frq mRNA levels were constantly high in the rco-1 wc double mutants, indicating that RCO-1 suppresses WC-independent transcription and promotes WC complex binding to the frq promoter. Furthermore, RCO-1 is required for maintaining normal chromatin structure at the frq locus. Deletion of H3K36 methyltransferase su(var)3-9-enhancer-of-zeste-trithorax-2 (SET-2) or the chromatin remodeling factor CHD-1 leads to WC-independent frq transcription and loss of overt rhythms. Together, our results uncover a previously unexpected regulatory mechanism for clock gene transcription.",
        "keywords": [
            "Clock gene frq",
            "H3K36me3",
            "RCO-1/Tup1",
            "Transcriptional repression"
        ],
        "venue": "Proceedings of the National Academy of Sciences of the United States of America",
        "year": 2013,
        "id": "osEny9xZ"
    },
    "8zq1BQn9": {
        "authors": [
            {
                "name": "Xiao Liu",
                "org": "State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University"
            },
            {
                "name": "Hongda Li",
                "org": "State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University"
            },
            {
                "name": "Qingqing Liu",
                "org": "State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University"
            },
            {
                "name": "Yanling Niu",
                "org": "State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University"
            },
            {
                "name": "Qiwen Hu",
                "org": "Department of Microbiology, College of Basic Medical Sciences, Third Military Medical University"
            },
            {
                "name": "Haiteng Deng",
                "org": "School of Life Sciences, Tsinghua University"
            },
            {
                "name": "Joonseok Cha",
                "org": "Department of Physiology, The University of Texas Southwestern Medical Center"
            },
            {
                "name": "Ying Wang",
                "org": "State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University"
            },
            {
                "name": "Yi Liu",
                "org": "Department of Physiology, The University of Texas Southwestern Medical Center"
            },
            {
                "name": "Qun He",
                "org": "State Key Laboratory of Agrobiotechnology and MOA Key Laboratory of Soil Microbiology, College of Biological Sciences, China Agricultural University"
            }
        ],
        "title": "Role for protein kinase A in the Neurospora circadian clock by regulating white collar-independent frequency transcription through phosphorylation of RCM-1",
        "abstract": "Rhythmic activation and repression of clock gene expression is essential for the eukaryotic circadian clock functions. In the Neurospora circadian oscillator, the transcription of the frequency (frq) gene is periodically activated by the White Collar (WC) complex and suppressed by the FRQ-FRH complex. We previously showed that there is WC-independent frq transcription and its repression is required for circadian gene expression. How WC-independent frq transcription is regulated is not known. We show here that elevated protein kinase A (PKA) activity results in WC-independent frq transcription and the loss of clock function. We identified RCM-1 as the protein partner of RCO-1 and an essential component of the clock through its role in suppressing WCindependent frq transcription. RCM-1 is a phosphoprotein and is a substrate of PKA in vivo and in vitro. Mutation of the PKAdependent phosphorylation sites on RCM-1 results in WC-independent transcription of frq and impaired clock function. Furthermore, we showed that RCM-1 is associated with the chromatin at the frq locus, a process that is inhibited by PKA. Together, our results demonstrate that PKA regulates frq transcription by inhibiting RCM-1 activity through RCM-1 phosphorylation.",
        "keywords": [
            ""
        ],
        "venue": "Molecular and Cellular Biology",
        "year": 2015,
        "id": "8zq1BQn9"
    },
    "pbZVtIZY": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Astronautics"
            },
            {
                "name": "Wei Sun",
                "org": "School of Astronautics"
            },
            {
                "name": "Guo-Biao Cai",
                "org": "School of Astronautics"
            }
        ],
        "title": "Simulation and experiment for preheating process of N2O monopropellant thruster with inner-heater",
        "keywords": [
            "Finite element analysis",
            "Inner-heating",
            "Monoprorellant thruster",
            "N2O",
            "Preheating"
        ],
        "venue": "Hangkong Dongli Xuebao/Journal of Aerospace Power",
        "year": 2013,
        "id": "pbZVtIZY"
    },
    "2GZ1n6mA": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": ""
            },
            {
                "name": "Hai-Bin Jin",
                "org": ""
            }
        ],
        "title": "High accurate measurement method on phase difference",
        "keywords": [
            "Fourier transform",
            "Interpolation",
            "Negative frequency spectrum leakage",
            "Phase difference",
            "Short-range spectrum leakage"
        ],
        "venue": "Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering",
        "year": 2010,
        "id": "2GZ1n6mA"
    },
    "3VOJoxZh": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering"
            },
            {
                "name": "Haibin Jin",
                "org": "Beijing Orient Institute of Metrology and Measurement Technology"
            }
        ],
        "title": "Spectral interpolation measurement algorithm of high accuracy on signals in power network",
        "keywords": [
            "Asynchronous sampling",
            "Fourier transforms",
            "Interpolation",
            "Leakages",
            "Measurement error"
        ],
        "venue": "Beijing Hangkong Hangtian Daxue Xuebao/Journal of Beijing University of Aeronautics and Astronautics",
        "year": 2010,
        "id": "3VOJoxZh"
    },
    "M0ML6f5f": {
        "authors": [
            {
                "name": "Kai Jia",
                "org": ""
            },
            {
                "name": "Jing Wu",
                "org": ""
            },
            {
                "name": "Haiming Shao",
                "org": ""
            }
        ],
        "title": "Relationship between time-domain and frequency-domain calibration on resistive voltage divider",
        "keywords": [
            "calibration",
            "frequency-domain",
            "Resistive voltage divider",
            "time-domain"
        ],
        "venue": "CPEM Digest (Conference on Precision Electromagnetic Measurements)",
        "year": 2012,
        "id": "M0ML6f5f"
    },
    "Lx81pYwl": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": ""
            },
            {
                "name": "Wei Zhao",
                "org": ""
            }
        ],
        "title": "A simple interpolation algorithm for measuring multi-frequency signal based on DFT",
        "keywords": [
            "Chebyshev best approximation",
            "Discrete Fourier transform",
            "Harmonic measurement",
            "Interpolation"
        ],
        "venue": "Measurement: Journal of the International Measurement Confederation",
        "year": 2009,
        "id": "Lx81pYwl"
    },
    "eqtyUTcu": {
        "authors": [
            {
                "name": "Guobiao Cai",
                "org": "School of Astronautics"
            },
            {
                "name": "Wei Sun",
                "org": "School of Astronautics"
            },
            {
                "name": "Xiaofang Mao",
                "org": "School of Astronautics"
            },
            {
                "name": "Jie Fang",
                "org": "School of Astronautics"
            },
            {
                "name": "Mao Li",
                "org": "School of Astronautics"
            },
            {
                "name": "Yue Han",
                "org": "School of Astronautics"
            },
            {
                "name": "Jing Wu",
                "org": "School of Astronautics"
            }
        ],
        "title": "Development of a nitrous oxide monopropellant micro-thruster at BUAA: 2009",
        "keywords": [
            ""
        ],
        "venue": "61st International Astronautical Congress 2010, IAC 2010",
        "year": 2010,
        "id": "eqtyUTcu"
    },
    "xhu9m6vC": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Jing-Jing Fu",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Chong Zhang",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            }
        ],
        "title": "Propagation characteristics of power line harmonic radiation in the ionosphere",
        "keywords": [
            "anisotropic medium",
            "electromagnetic waves",
            "ionosphere",
            "power line harmonic radiation"
        ],
        "venue": "Chinese Physics B",
        "year": 2014,
        "id": "xhu9m6vC"
    },
    "0KpcUAC4": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": ""
            },
            {
                "name": "Chun-Yan Xiao",
                "org": ""
            }
        ],
        "title": "Analytical solutions to the electromagnetic field in a cylindrical shell excited by external axial current",
        "keywords": [
            "Analytical solution",
            "Axial current",
            "Electromagnetic field",
            "Ferrite shell"
        ],
        "venue": "Chinese Physics B",
        "year": 2010,
        "id": "0KpcUAC4"
    },
    "LfHzj4Pb": {
        "authors": [
            {
                "name": "Sheng Gao",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Haibin Jin",
                "org": "Beijing Orient Institute of Measurement and Test (BOIMT)"
            }
        ],
        "title": "New method for power flicker calibration based on interpolated DFT",
        "keywords": [
            ""
        ],
        "venue": "2014 31th URSI General Assembly and Scientific Symposium, URSI GASS 2014",
        "year": 2014,
        "id": "LfHzj4Pb"
    },
    "0iw5QGkC": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": ""
            },
            {
                "name": "Guo-Zhou Zhang",
                "org": ""
            },
            {
                "name": "Guo-Biao Cai",
                "org": ""
            }
        ],
        "title": "Design and experiment of gaseous hydrogen/oxygen engine igniting with electric spark igniting in vacuum",
        "keywords": [
            "Electric spark igniting",
            "Hydrogen/oxygen",
            "Shrink ratio engine",
            "Sonic nozzle with ball-end seal",
            "Vacuum"
        ],
        "venue": "Hangkong Dongli Xuebao/Journal of Aerospace Power",
        "year": 2014,
        "id": "0iw5QGkC"
    },
    "uFjU8xWh": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering"
            },
            {
                "name": "Jingjing Fu",
                "org": "School of Automation Science and Electrical Engineering"
            }
        ],
        "title": "A review on power line harmonic radiation monitored by DEMETER satellite",
        "keywords": [
            "DEMETER satellite",
            "Electromagnetic disturbance",
            "Ionosphere",
            "Magnetosphere",
            "Power line harmonic radiation"
        ],
        "venue": "Acta Seismologica Sinica",
        "year": 2011,
        "id": "uFjU8xWh"
    },
    "vvCHEd2g": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": ""
            },
            {
                "name": "Chong Zhang",
                "org": ""
            },
            {
                "name": "Jingjing Fu",
                "org": ""
            },
            {
                "name": "Qishuang Ma",
                "org": ""
            }
        ],
        "title": "Analysis on power line harmonic radiation in China space",
        "keywords": [
            "Electromagnetic environment",
            "Ionosphere",
            "Power line harmonic radiation",
            "Power spectrum",
            "Time-frequency analysis",
            "Ultra-high voltage power transmission"
        ],
        "venue": "Beijing Hangkong Hangtian Daxue Xuebao/Journal of Beijing University of Aeronautics and Astronautics",
        "year": 2014,
        "id": "vvCHEd2g"
    },
    "CMGJqEDB": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Zhi-Wei Zhou",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Xu Yan",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            }
        ],
        "title": "Propagation characteristics of power line harmonic radiation into the stratified anisotropic ionosphere",
        "keywords": [
            "Earth",
            "Ionosphere",
            "Power line harmonic radiation",
            "Stratified anisotropic media"
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2015,
        "id": "CMGJqEDB"
    },
    "xOJfyRwE": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering"
            },
            {
                "name": "Wei Zhao",
                "org": "State Key Laboratory of Power Systems"
            }
        ],
        "title": "Uncertainty evaluation model for sampling based instruments",
        "keywords": [
            "Data acquisition",
            "Evaluation",
            "Signal processor",
            "Uncertainty"
        ],
        "venue": "Qinghua Daxue Xuebao/Journal of Tsinghua University",
        "year": 2010,
        "id": "xOJfyRwE"
    },
    "B8WnE0Y7": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering"
            },
            {
                "name": "Kaifeng Qu",
                "org": "Department of Electrical Engineering"
            },
            {
                "name": "Wei Zhao",
                "org": "Department of Electrical Engineering"
            }
        ],
        "title": "A new precise measurement method on interharmonics",
        "keywords": [
            "Accuracy",
            "DFT",
            "Interpolation algorithm",
            "Leakage"
        ],
        "venue": "2009 IEEE Intrumentation and Measurement Technology Conference, I2MTC 2009",
        "year": 2009,
        "id": "B8WnE0Y7"
    },
    "Zk3q7TzD": {
        "authors": [
            {
                "name": "Jing Wu",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Sheng Gao",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            },
            {
                "name": "Yuxiao Liu",
                "org": "School of Automation Science and Electrical Engineering, Beihang University"
            }
        ],
        "title": "Calculation on the ion flow field under HVDC transmission lines considering wind effects",
        "keywords": [
            "Corona",
            "Deutsch assumption",
            "Hvdc transmission line",
            "Ion flow field",
            "Wind effects"
        ],
        "venue": "Journal of Electrical Engineering and Technology",
        "year": 2015,
        "id": "Zk3q7TzD"
    },
    "tTWs3A0Z": {
        "authors": [
            {
                "name": "Tie-Li Sun",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Si-Ying Cheng",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Di Wu",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Xiao-Xin Sun",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Feng-Qin Yang",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            }
        ],
        "title": "A novel multi-label clustering method based on distance measure",
        "abstract": "Clustering is one of the key techniques in data mining. Almost, traditional clustering methods just focus on single-label datasets but do not concern the multi-label problem, where a data point can belong to more than one cluster. In this paper, we propose a new multi-label clustering method based on distance measure (MCDM). F-measure is a widely used clustering validation measure, but its value may be out of the range [0, 1] in multi-label clustering. We revise F-measure in order to guarantee the value is in the range [0, 1]. Experiments on benchmark datasets demonstrate that the multiple clustering we proposed is effective and the revision of F-measure is reasonable.",
        "keywords": [
            "Distance measure",
            "Multi-label clustering",
            "Multi-label clustering evaluation"
        ],
        "venue": "ICIC Express Letters",
        "year": 2012,
        "id": "tTWs3A0Z"
    },
    "ReE8zQYb": {
        "authors": [
            {
                "name": "Yingjie Jiang",
                "org": ""
            },
            {
                "name": "Tieli Sun",
                "org": ""
            },
            {
                "name": "Huai Pan",
                "org": ""
            },
            {
                "name": "Di Wu",
                "org": ""
            }
        ],
        "title": "Research on ontology-based short text classification",
        "abstract": "Currently, short text classification has caught more researchers' attention. However, the performance of traditional classification method is not significant. Ontology offers great potential as a powerful knowledge sharing technology to enhance computer learning. In this paper, a framework of ontology-based short text classification is explicated, and a method of enriching short text information with HowNet and refined similarity calculation are proposed. The comparative experiment results show that our method achieves better performance without training datasets. This study has great practical value and wide application prospects. \u00a9 2011 ISSN 2185-2766.",
        "keywords": [
            "Information complement",
            "Short text",
            "Sparseness"
        ],
        "venue": "ICIC Express Letters, Part B: Applications",
        "year": 2011,
        "id": "ReE8zQYb"
    },
    "pKmuGWGc": {
        "authors": [
            {
                "name": "Di Wu",
                "org": ""
            },
            {
                "name": "Yongjing Zhang",
                "org": ""
            },
            {
                "name": "Fengqin Yang",
                "org": ""
            },
            {
                "name": "Siying Cheng",
                "org": ""
            },
            {
                "name": "Hongguang Sun",
                "org": ""
            },
            {
                "name": "Tieli Sun",
                "org": ""
            }
        ],
        "title": "Improved k-means algorithm based on optimizing initial cluster centers",
        "abstract": "The k-means algorithm is known to be a fast clustering algorithm. However, it is sensitive to initial cluster centers and the number K must be pre-set. To solve the problem, the k-means algorithm based on Max-Min distance algorithm has been introduced, but it cannot handle noise data. In this paper, we present the improved Unweighted Pair Group Method with Arithmetic Mean (UPGMA) algorithm with Max-Min distance method (IU-M) k-means algorithm, data sampling and the improved UPGMA algorithm are used before the Max-Min distance algorithm to get favorable initial cluster centers, and the number K can be determined intelligently. Comparative experiments are done on three benchmark datasets. The results demonstrate that the IU-M k-means algorithm is efficient and effective. \u00a9 2013 ICIC International.",
        "keywords": [
            "Clustering",
            "Initial cluster centers",
            "Max-Min distance"
        ],
        "venue": "ICIC Express Letters",
        "year": 2013,
        "id": "pKmuGWGc"
    },
    "frxj4cKd": {
        "authors": [
            {
                "name": "Di Wu",
                "org": "School of Computer Science and Information Technology"
            },
            {
                "name": "Lanlan Wu",
                "org": "School of Computer Science and Information Technology"
            },
            {
                "name": "Tieli Sun",
                "org": "School of Computer Science and Information Technology"
            },
            {
                "name": "Yingjie Jiang",
                "org": "Art Experiment Middle School of Changchun"
            },
            {
                "name": "Fengqin Yang",
                "org": "School of Computer Science and Information Technology"
            }
        ],
        "title": "Ontology-based information extraction technology",
        "abstract": "The performance of information extraction can be effectively improved through use of ontology. Based on the discussion of constructing ontology technology and standards related to, on the basis of three layers framework to constructing ontology to resume ontology, university teachers Racer reasoning machine to implement consistency and accuracy testing. Based on this improved the WordNet similarity calculation, through the use of WordNet semantic similarity calculation and manually collecting method of combining the concept of this body, obtain the specific examples, the result proves that the result can be extracted remarkably enhanced. \u00a9 2011 IEEE.",
        "keywords": [
            "Ontology construction",
            "Similarity calculation",
            "WordNet"
        ],
        "venue": "2011 International Conference on Internet Technology and Applications, iTAP 2011 - Proceedings",
        "year": 2011,
        "id": "frxj4cKd"
    },
    "Bp9eDy28": {
        "authors": [
            {
                "name": "Lin Sun",
                "org": "Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University"
            },
            {
                "name": "Di Wu",
                "org": "Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University"
            },
            {
                "name": "Xin Ning",
                "org": "Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University"
            },
            {
                "name": "Guang Yang",
                "org": "Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University"
            },
            {
                "name": "Ziheng Lin",
                "org": "Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University"
            },
            {
                "name": "Meihong Tian",
                "org": "School of Physical Education, Northeast Normal University"
            },
            {
                "name": "Yifa Zhou",
                "org": "Jilin Province Key Laboratory on Chemistry and Biology of Natural Drugs in Changbai Mountain, School of Life Sciences, Northeast Normal University"
            }
        ],
        "title": "\u03b1-Amylase-assisted extraction of polysaccharides from Panax ginseng",
        "keywords": [
            "Extraction",
            "Panax ginseng",
            "Pectin",
            "Polysaccharide",
            "\u03b1-Amylase"
        ],
        "venue": "International Journal of Biological Macromolecules",
        "year": 2015,
        "id": "Bp9eDy28"
    },
    "HOUUyZ6A": {
        "authors": [
            {
                "name": "Di Wu",
                "org": "School of Computer Science and Information Technolohy"
            },
            {
                "name": "Xiaoxue Wang",
                "org": "School of Computer Science and Information Technolohy"
            },
            {
                "name": "Ting Zuo",
                "org": "Network Center"
            },
            {
                "name": "Tieli Sun",
                "org": "School of Computer Science and Information Technolohy"
            },
            {
                "name": "Fengqin Yang",
                "org": "School of Computer Science and Information Technolohy"
            }
        ],
        "title": "A Sequential Pattern Mining algorithm with time constraints based on vertical format",
        "abstract": "An improved algorithm called MSPVF (Mining Sequential Patterns using Time-Constraint based on Vertical Format) based on Apriori is presented. Time constraints is added on Apriori algorithm in order to enhance users' satisfaction,. Meanwhile, a new five-tuple list object is used by the MSPVF algorithm to store data in vertical format to simplify the mining process. The experimental results show that the improved algorithm MSPVF is more efficient than the improved GSP algorithm based on AprioriAll. \u00a9 2010 IEEE.",
        "keywords": [
            "Apriori-like algorithm",
            "MSPVF",
            "Time constraints",
            "Vertical format"
        ],
        "venue": "2nd International Conference on Information Science and Engineering, ICISE2010 - Proceedings",
        "year": 2010,
        "id": "HOUUyZ6A"
    },
    "416imPdH": {
        "authors": [
            {
                "name": "Huijie Zhang",
                "org": ""
            },
            {
                "name": "Zhiqiang Ma",
                "org": ""
            },
            {
                "name": "Guangxu Ren",
                "org": ""
            },
            {
                "name": "Di Wu",
                "org": ""
            },
            {
                "name": "Fengqin Yang",
                "org": ""
            }
        ],
        "title": "Feature selection method for 3d terrain model based on profile recognition and polygon-breaking algorithm",
        "abstract": "This paper presents a framework to support feature visualization in 3D terrain roaming. In this framework, feature points are redefined based on the target points of profile recognition and polygon-breaking algorithm, combined with connotative hierarchical structure. The diamond neighborhood space is proposed to decrease the computation complexity of feature selection. Additionally, feature connection and polygon breaking have been completed in order to build the whole framework. Finally, experiments have been conducted on the GTOPO30 terrain models. As a result, our framework can meet real time feature visualization and the quality of skeleton feature selection is good as a whole. By further test, the frame rate of terrain roaming with feature selection is satisfied. \u00a9 2013 ICIC International.",
        "keywords": [
            "Hierarchy structure",
            "Mesh model",
            "Profile recognition",
            "Terrain skeleton"
        ],
        "venue": "ICIC Express Letters",
        "year": 2013,
        "id": "416imPdH"
    },
    "1gZEn583": {
        "authors": [
            {
                "name": "Ling Ni",
                "org": "State Key Laboratory of Electroanalytical Chemistry"
            },
            {
                "name": "Wei-Wei Yang",
                "org": "State Key Laboratory of Electroanalytical Chemistry"
            },
            {
                "name": "Zong-Jun Li",
                "org": "State Key Laboratory of Electroanalytical Chemistry"
            },
            {
                "name": "Di Wu",
                "org": "School of Computer Science and Information Technology"
            },
            {
                "name": "Xiang Gao",
                "org": "State Key Laboratory of Electroanalytical Chemistry"
            }
        ],
        "title": "Regioselective oxazolination of C ",
        "abstract": "Oxazolination of C ",
        "keywords": [
            ""
        ],
        "venue": "Journal of Organic Chemistry",
        "year": 2012,
        "id": "1gZEn583"
    },
    "9IrWPio1": {
        "authors": [
            {
                "name": "Fengqin Yang",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Wanting Zhou",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Di Wu",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Xiaoxin Sun",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Hongguang Sun",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            },
            {
                "name": "Tieli Sun",
                "org": "Key Laboratory of Intelligent Information Processing of Jilin Universities"
            }
        ],
        "title": "An improved incremental Na\u00efve Bayesian for sentiment classification",
        "abstract": "Web review mining and sentiment analysis can help customers effectively. Currently the existing methods are mainly divided into supervised and unsupervised. This paper adopted supervised method and proposed an improved incremental Na\u00efve Bayesian (Named T-INB) for Sentiment Classification. In order to decrease the effect of noise data in traditional incremental Bayesian, a threshold is introduced and it can control the order in which data is added to the original training dataset. Experimental results on a movie review data set show our approach is feasible and effective. \u00a9 2013 ICIC International.",
        "keywords": [
            "Incremental Na\u00efve Bayesian",
            "Review mining",
            "Sentiment analysis"
        ],
        "venue": "ICIC Express Letters",
        "year": 2013,
        "id": "9IrWPio1"
    },
    "WgbYEJ1l": {
        "authors": [
            {
                "name": "Juan Gao",
                "org": "School of Life Sciences"
            },
            {
                "name": "Wenjing Xu",
                "org": "Plant Protection Institute"
            },
            {
                "name": "Qiang Fang",
                "org": "School of Chemical and Life Sciences"
            },
            {
                "name": "Fei Liang",
                "org": "School of Life Sciences"
            },
            {
                "name": "Rutian Jin",
                "org": "School of Life Sciences"
            },
            {
                "name": "Di Wu",
                "org": "School of Life Sciences"
            },
            {
                "name": "Guihua Tai",
                "org": "School of Life Sciences"
            },
            {
                "name": "Yifa Zhou",
                "org": "School of Life Sciences"
            }
        ],
        "title": "Efficient biotransformation for preparation of pharmaceutically active ginsenoside Compound K by Penicillium oxalicum sp. 68",
        "abstract": "Pathogenic fungus Penicillium oxalicum sp. 68 was screened from soil and identified by ITS sequencing. The strain was found to be able to transform protopanaxadiol-type ginsenosides to produce a series of bioactive metabolites. Glycosidase from the culture of P. oxalicum sp. 68 was partially purified with a simple two-step procedure consisting of DEAE-cellulose chromatography and ammonium sulfate precipitation. Bioactive ginsenoside Compound K was prepared selectively and efficiently by biotransformation of ginsenosides Rb1, Rb2, Rc and Rd using the partially purified glycosidase. The optimal conditions for transforming Rb1 into Compound K were pH 4.0, 55 C and 0.5 mg mL",
        "keywords": [
            "Biotransformation",
            "Compound K",
            "Ginsenoside",
            "Glycosidase",
            "Penicillium oxalicum"
        ],
        "venue": "Annals of Microbiology",
        "year": 2013,
        "id": "WgbYEJ1l"
    },
    "xlSbG1gD": {
        "authors": [
            {
                "name": "Di Wu",
                "org": ""
            },
            {
                "name": "Yifei Wang",
                "org": ""
            },
            {
                "name": "Fengqin Yang",
                "org": ""
            }
        ],
        "title": "Improvement of term weighting algorithm in text classification",
        "abstract": "Classification is a pervasive problem that encompasses diverse applications. The tfidf term weighting scheme is often used in the vector space model and plays a crucial role in text classification. In this paper, TFIDF algorithm is studied deeply. Through analyzing the advantage and disadvantage, an improved TFIDF algorithm named TFIDF-BC-WC is proposed. Comparative experiments are done on the real world dataset by using these algorithms. The results demonstrate that TFIDF-BC-WC algorithm is efficient and effective.",
        "keywords": [
            "Term weighting",
            "Text classification",
            "TFIDF"
        ],
        "venue": "ICIC Express Letters",
        "year": 2012,
        "id": "xlSbG1gD"
    },
    "i2TDMgpX": {
        "authors": [
            {
                "name": "Kai Deng",
                "org": "School of Marine Science and Technology, Harbin Institute of Technology"
            },
            {
                "name": "Qi-Yong Huai",
                "org": "Marine College, Shandong University"
            },
            {
                "name": "Zhi-Lun Shen",
                "org": "School of Marine Science and Technology, Harbin Institute of Technology"
            },
            {
                "name": "Hui-Jing Li",
                "org": "School of Marine Science and Technology, Harbin Institute of Technology"
            },
            {
                "name": "Chen Liu",
                "org": "School of Marine Science and Technology, Harbin Institute of Technology"
            },
            {
                "name": "Yan-Chao Wu",
                "org": "School of Marine Science and Technology, Harbin Institute of Technology"
            }
        ],
        "title": "Rearrangement of dypnones to 1,3,5-triarylbenzenes",
        "abstract": "Rearrangement of dypnones to 1,3,5-triarylbenzenes is described. The reaction is proposed to involve an aldol-type self-condensation of dypnones, followed by an intramolecular [2 + 2] cycloaddition and a retro-[2 + 2] cycloaddition. The reaction goes smoothly under obviously milder conditions in comparison to the cyclotrimerization of acetophenones to 1,3,5-triarylbenzenes (10 mol % of TsOH, 80 \u00b0C versus 130-148 \u00b0C). This unexpected rearrangement would provide new possible considerations in dypnone-involved organic synthesis.",
        "keywords": [
            ""
        ],
        "venue": "Organic Letters",
        "year": 2015,
        "id": "i2TDMgpX"
    },
    "yVEXRyiB": {
        "id": "yVEXRyiB",
        "title": "Efficacy and tolerability of intravenous iron for patients with restless legs syndrome: evidence from randomized trials and observational studies",
        "abstract": "Abstract   Objective  Restless legs syndrome (RLS) is a common neurological disorder of unclear pathophysiology that appears to involve an iron deficiency in the brain. Some studies, but not others, suggest that intravenous injection of iron can reduce RLS severity.    Method  The databases Web of Science, PubMed, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were searched for randomized controlled trials, cohort studies and case-control studies of intravenous iron therapy to treat RLS. Eligible studies were meta-analyzed using Stata 12.0.    Results  This analysis indicated that IV iron was more efficacious than placebo in treating RLS (OR: 4.71,95%CI 4.21-5.21,p    Conclusion  The available evidence suggests that intravenous iron is effective and tolerable for patients with RLS regardless of peripheral iron status.",
        "keywords": [
            "Ferric carboxymaltose",
            "Iron dextran",
            "Iron sucrose",
            "Restless legs syndrome"
        ],
        "authors": [
            {
                "name": "Xinglong Yang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China."
            },
            {
                "name": "Baiyuan Yang",
                "org": "Department of Neurology, Seventh People's Hospital of Chengdu, 610041, PR China."
            },
            {
                "name": "Mao Ming",
                "org": "Department of Emergency Internal Medicine Guang'an Men South Area Hospital, China Academy of Chinese Medical Sciences, 102600, PR China."
            },
            {
                "name": "Shimei Li",
                "org": "Department of Anesthesia, Kunming Xishan District People's Hospital, Kunming, Yunnan Province, 650100, PR China."
            },
            {
                "name": "Fang Wang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China."
            },
            {
                "name": "Zhigang Zhu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China."
            },
            {
                "name": "Chang Ji",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China."
            },
            {
                "name": "Juan Long",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China."
            },
            {
                "name": "Fayun Hu",
                "org": "Department of Neurology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, Sichuan Province, 610041, PR China."
            },
            {
                "name": "Zhong Xu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China."
            },
            {
                "name": "Hui Ren",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China. Electronic address: Huiren2006@163.com."
            },
            {
                "name": "Bin Liu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, 650032, PR China. Electronic address: ynkmlba@163.com."
            }
        ],
        "venue": "Sleep Medicine",
        "year": 2019
    },
    "c4xwrT6H": {
        "id": "c4xwrT6H",
        "title": "Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.",
        "abstract": "Our meta-analysis provides the first reliable pooled estimate of RLS prevalence among individuals with migraine, and it provides strong evidence that RLS risk is higher among individuals with migraine than among controls.",
        "keywords": [
            "Meta-analysis",
            "Migraine",
            "Prevalence",
            "Restless legs syndrome"
        ],
        "authors": [
            {
                "name": "Xinglong Yang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China."
            },
            {
                "name": "Bin Liu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China."
            },
            {
                "name": "Baiyuan Yang",
                "org": "Department of Neurology, The Seventh People's Hospital of Chengdu, Chengdu, 650041, Sichuan, People's Republic of China."
            },
            {
                "name": "Shimei Li",
                "org": "Department of Anesthesia, Kunming Xishan District People's Hospital, Kunming, 650100, Yunnan, People's Republic of China."
            },
            {
                "name": "Fang Wang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China."
            },
            {
                "name": "Kelu Li",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China."
            },
            {
                "name": "Fayun Hu",
                "org": "Department of Neurology, West China Hospital, SCU, Chengdu, 650041, Sichuan, People's Republic of China."
            },
            {
                "name": "Hui Ren",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China."
            },
            {
                "name": "Zhong Xu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, People's Republic of China. xz0702@126.com."
            }
        ],
        "venue": "Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology",
        "year": 2018
    },
    "9ziqPcyZ": {
        "id": "9ziqPcyZ",
        "title": "Decreased Serum ferritin may be associated with increased restless legs syndrome in Parkinson's disease: a meta-analysis for the diagnosis of RLS in PD patients.",
        "abstract": "This meta-analysis may provide the first reliable pooled estimate of the correlation between abnormal iron metabolism and RLS in PD. The available evidence indicates that levels of ferritin, but not of serum iron or hemoglobin, correlate significantly with RLS in PD, with lower ferritin levels correlating to greater prevalence of RLS.",
        "keywords": [
            "Ferritin",
            "Meta-analysis",
            "Parkinson's disease",
            "Restless legs syndrome"
        ],
        "authors": [
            {
                "name": "Kelu Li",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Bin Liu",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Fang Wang",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Jianjian Bao",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Chongmin Wu",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Xiaodong Huang",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Fayun Hu",
                "org": "b Department of Neurology , West China Hospital, SCU , Chengdu , Sichuan Province , 650041 , P.R. China."
            },
            {
                "name": "Zhong Xu",
                "org": ""
            },
            {
                "name": "Hui Ren",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            },
            {
                "name": "Xinglong Yang",
                "org": "a Department of Geriatric Neurology , First Affiliated Hospital of Kunming Medical University , Kunming , Yunnan Province , 650032 , P.R. China."
            }
        ],
        "venue": "The International journal of neuroscience",
        "year": 2019
    },
    "1akq32y6": {
        "id": "1akq32y6",
        "title": "UNC13A variant rs12608932 is associated with increased risk of amyotrophic lateral sclerosis and reduced patient survival: a meta-analysis.",
        "abstract": "The present meta-analysis suggests that rs12608932(C) is associated with increased ALS susceptibility, especially in Caucasian and European subjects, and that the CC genotype of rs12608932 is associated with reduced ALS patient survival.",
        "keywords": [
            "Amyotrophic lateral sclerosis",
            "Meta-analysis",
            "Risk",
            "Survival",
            "UNC13A",
            "rs12608932"
        ],
        "authors": [
            {
                "name": "Baiyuan Yang",
                "org": "Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, 690041, Sichuan Province, People's Republic of China."
            },
            {
                "name": "Haixia Jiang",
                "org": "Department of Anesthesia, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Fang Wang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Shimei Li",
                "org": "Department of Anesthesia, Kunming Xishan District People's Hospital, Kunming, 650100, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Chongmin Wu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Jianjian Bao",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Yongyun Zhu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Zhong Xu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Bin Liu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Hui Ren",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China."
            },
            {
                "name": "Xinglong Yang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, People's Republic of China. yxldoc11@163.com."
            }
        ],
        "venue": "Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology",
        "year": 2019
    },
    "HVE3x60C": {
        "id": "HVE3x60C",
        "title": "Association Between Serum Uric Acid Levels and Benign Paroxysmal Positional Vertigo: A Systematic Review and Meta-Analysis of Observational Studies.",
        "abstract": " The objective of the present study was to meta-analyze relevant literature to gain a comprehensive understanding of the potential relationship between serum uric acid levels and risk of benign paroxysmal positional vertigo (BPPV).  The databases of PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure, Wanfang, and SinoMed were systematically searched for observational case-control studies of the association between BPPV and serum uric acid levels published up to October 2018. Data from eligible studies were meta-analyzed using Stata 12.0.  A total of 12 studies were included in the analysis. There was a strong tendency for serum uric acid levels to be associated with risk of BPPV among studies conducted in China (OR 0.69, 95%CI 0.01-1.40,  = 0.053), but not among studies outside China (OR 1.07, 95%CI 1.08-3.22,  = 0.33). Across all studies, serum uric acid level was significantly higher among individuals with BPPV than among controls (OR 0.78, 95%CI 0.15-1.41,  = 0.015), yet it did not independently predict risk of the disorder (OR 1.003, 95%CI 0.995-1.012,  = 0.471).  The available evidence suggests that BPPV is associated with elevated levels of serum uric acid, but these levels may not be an independent risk factor of BPPV.",
        "keywords": [
            "benign paroxysmal positional vertigo",
            "meta analysis",
            "otolithiasis",
            "peripheral vertigo",
            "serum uric acid"
        ],
        "authors": [
            {
                "name": "Xinglong Yang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            },
            {
                "name": "Baiyuan Yang",
                "org": "Department of Neurology, Seventh People's Hospital of Chengdu, Chengdu, China."
            },
            {
                "name": "Mengjun Wu",
                "org": "Department of Anesthesiology, Chengdu Women and Children's Central Hospital, Chengdu, China."
            },
            {
                "name": "Fang Wang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            },
            {
                "name": "Xiaodong Huang",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            },
            {
                "name": "Kelu Li",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            },
            {
                "name": "Zhiwei Mao",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            },
            {
                "name": "Zhong Xu",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            },
            {
                "name": "Hui Ren",
                "org": "Department of Geriatric Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, China."
            }
        ],
        "venue": "Frontiers in neurology",
        "year": 2019
    },
    "aQS2BX4X": {
        "authors": [
            {
                "name": "Zhi-Gang Zhang",
                "org": "School of Civil Engineering and Architecture"
            },
            {
                "name": "Chun-Sheng Qiao",
                "org": "School of Civil Engineering and Architecture"
            }
        ],
        "title": "Improved empirical determination of strength parameter for jointed rock masses and its application in engineering",
        "abstract": "During the course of numerical computation and stability evaluation on the jointed rock masses engineering, the determination of strength parameters is very important. When in-situ tests cannot be taken due to certain causes, the empirical determination is a good choose. This paper, based on collecting many empirical determinations of strength parameter for jointed rock masses all over the world, puts forward the improved empirical determination of strength parameters, that is to say, \" size effect reduction factor \" and \" jointed rock reduction factor \" of the intact rock specimen for the study on jointed lock mass strength parameter, and applies to the a typical location of the dam, which proves that this methodology is feasible and rational, and a new way for study of strength parameter in jointed rock masses is established.",
        "keywords": [
            "Empirical determination",
            "Jointed rock masses",
            "Strength parameter"
        ],
        "venue": "Beijing Jiaotong Daxue Xuebao/Journal of Beijing Jiaotong University",
        "year": 2006,
        "id": "aQS2BX4X"
    },
    "KMMydvV1": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "Suzhou University of Science and Technology"
            },
            {
                "name": "Xiaohui Bao",
                "org": "Aichi Institute of Technology"
            },
            {
                "name": "Yoshihisa Uchida",
                "org": "Aichi Institute of Technology"
            },
            {
                "name": "Jingnan Liu",
                "org": "Southeast University"
            },
            {
                "name": "Y.P. Kathuria",
                "org": "Aichi Institute of Technology"
            },
            {
                "name": "Hideo Furuhashi",
                "org": "Aichi Institute of Technology"
            },
            {
                "name": "Yoshiyuki Uchida",
                "org": "Aichi Institute of Technology"
            }
        ],
        "title": "Blue spectral shift of P3HT organic film by KrF excimer laser ablation",
        "abstract": "A technique for morphology control of self-assembled organic films based on laser ablation is presented. The regioregular poly 3-hexylthiophene (RR-P3HT) films prepared by using drop casting method and spin coating method are irradiated and ablated by the ultraviolet KrF excimer laser. Absorption spectra and XRD profiles of the films are investigated. For spin coated films, Blue absorption spectral shift is observed; For drop cast films, Blue shift in the absorption spectra, accompanied with the disappearance of the peak intensity of XRD profiles, are observed. The results indicate that molecular structure has been changed due to photo-thermal effect and molecule cutting effect of laser ablation. \u00a9 2009 SPIE.",
        "keywords": [
            "Laser ablation",
            "Organic film",
            "Poly 3-hexylthiophene",
            "Polymer thin film"
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2009,
        "id": "KMMydvV1"
    },
    "U5SDLWFF": {
        "authors": [
            {
                "name": "Xia Xu",
                "org": "Department of Biology Sciences, institute of environment Science"
            },
            {
                "name": "Qiong Gao",
                "org": "State Key Laboratory of Earth Surface Processes and Resource Ecology"
            },
            {
                "name": "Changhui Peng",
                "org": "Department of Biology Sciences, institute of environment Science"
            },
            {
                "name": "Xuefeng Cui",
                "org": "College of Global Change and Earth System Research"
            },
            {
                "name": "Yinghui Liu",
                "org": "Academy of Resource"
            },
            {
                "name": "Li Jiang",
                "org": "Academy of Disaster Reduction and Emergency Management"
            }
        ],
        "title": "Integrating global socio-economic influences into a regional land use change model for China",
        "abstract": "With rapid economic development and urbanization, land use in China has experienced huge changes in recent years; and this will probably continue in the future. Land use problems in China are urgent and need further study. Rapid land-use change and economic development make China an ideal region for integrated land use change studies, particularly the examination of multiple factors and global-regional interactions in the context of global economic integration. This paper presents an integrated modeling approach to examine the impact of global socio-economic processes on land use changes at a regional scale. We develop an integrated model system by coupling a simple global socio-economic model (GLOBFOOD) and regional spatial allocation model (CLUE). The model system is illustrated with an application to land use in China. For a given climate change, population growth, and various socio-economic situations, a global socio-economic model simulates the impact of global market and economy on land use, and quantifies changes of different land use types. The land use spatial distribution model decides the type of land use most appropriate in each spatial grid by employing a weighted suitability index, derived from expert knowledge about the ecosystem state and site conditions. A series of model simulations will be conducted and analyzed to demonstrate the ability of the integrated model to link global socioeconomic factors with regional land use changes in China. The results allow an exploration of the future dynamics of land use and landscapes in China. \u00a9 2013 Higher Education Press and Springer-Verlag Berlin Heidelberg.",
        "keywords": [
            "China",
            "global socio-economic influence",
            "integrating",
            "land use change model"
        ],
        "venue": "Frontiers of Earth Science",
        "year": 2014,
        "id": "U5SDLWFF"
    },
    "Bxu3f734": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "School of Economics, Renmin University of China"
            },
            {
                "name": "Feng Wu",
                "org": "State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University"
            },
            {
                "name": "Yu Liu",
                "org": "Institute of Policy and Management, Chinese Academy of Sciences"
            },
            {
                "name": "Xiangzheng Deng",
                "org": "Center for Chinese Agricultural Policy, Institute of Geographic Sciences and Natural Resources, Research, Chinese Academy of Sciences"
            }
        ],
        "title": "Modeling the impacts of urbanization and industrial transformation on water resources in China: An integrated hydro-economic cge analysis",
        "abstract": "Pressure on existing water resources in China is expected to increase with undergoing rapid demographic transformation, economic development, and global climate changes. We investigate the economy-wide impacts of projected urban population growth and economic structural change on water use and allocation in China. Using a multi-regional CGE (Computable General Equilibrium) model, TERM (The Enormous Regional Model), we explore the implications of selected future water scenarios for China's nine watershed regions. Our results indicate that urbanization and industrial transformation in China will raise the opportunity cost of water use and increase the competition for water between non-agricultural users and irrigation water users. The growth in water demand for domestic and industrial uses reduces the amount of water allocated to agriculture, particularly lower-value and water-intensive field crops. As a response, farmers have the incentive to shift their agricultural operations from traditional field crop production to higher-value livestock or intensive crop production. In addition, our results suggest that growing water demand due to urbanization and industrial transformation will raise the shadow price of water in all nine river basins. Finally, we find that national economic growth is largely attributable to urbanization and non-agricultural productivity growth.",
        "keywords": [
            "Economic structural change",
            "Multi-regional CGE model",
            "Nine river basins",
            "Shadow price",
            "Urban population growth",
            "Water accounts",
            "Water use and allocation"
        ],
        "venue": "Sustainability (Switzerland)",
        "year": 2014,
        "id": "Bxu3f734"
    },
    "Kk5kbtMs": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Xing-Fa Dong",
                "org": ""
            },
            {
                "name": "Yong-Lin Huang",
                "org": ""
            },
            {
                "name": "Dong-Sheng Zhang",
                "org": ""
            },
            {
                "name": "Gui-Yun Kai",
                "org": ""
            },
            {
                "name": "Xiao-Yi Dong",
                "org": ""
            }
        ],
        "title": "A dual-wavelength FBG based on photosensitivity and its application",
        "abstract": "A novel dual-wavelength fiber Bragg grating (FBG) fabricated by using photosensitivity is experimentally demonstrated. The reflectivity and the separation of the two Bragg wavelengths are controlled by using moving-exposure technique. A grating with two-equal transmission peak of 20.25 dB is obtained by using this method and the separation of the two Bragg wavelengths is about 0.8 nm. With the grating, an optical add/drop multiplexer (OADM) that allows dropping two fixed wavelength channels is proposed.",
        "keywords": [
            "Add/drop multiplexer (OADM)",
            "Dual-wavelength fiber Bragg grating",
            "Photosensitivity"
        ],
        "venue": "Bandaoti Guangdian/Semiconductor Optoelectronics",
        "year": 2005,
        "id": "Kk5kbtMs"
    },
    "VRVeOQez": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "University of Science and Technology of Suzhou"
            },
            {
                "name": "Dong-Sheng Zhang",
                "org": "University of Science and Technology of Suzhou"
            },
            {
                "name": "Xin-Fa Dong",
                "org": "University of Science and Technology of Suzhou"
            },
            {
                "name": "Gui-Yun Kai",
                "org": "University of Science and Technology of Suzhou"
            },
            {
                "name": "Xiao-Yi Dong",
                "org": "Institute of Modern Optics"
            }
        ],
        "title": "Measurement of photo-induced birefringence in germanosilicate fibers",
        "abstract": "In this paper, we report a novel method for accurately measuring the photo-induced birefringence of germanosilicate fibers by using an all fiber Mach-Zehnder interferometer. The results indicate that the photo-induced normalized birefringence of C",
        "keywords": [
            "Germanosilicate fibers",
            "Mach-Zehnder interferometer",
            "Photo-induced birefringence"
        ],
        "venue": "Frontiers of Physics in China",
        "year": 2009,
        "id": "VRVeOQez"
    },
    "xNZ8IuHG": {
        "authors": [
            {
                "name": "Xin Zhang",
                "org": "Dept. of Electronic Engineering"
            },
            {
                "name": "Li Jiang",
                "org": "Dept. of Electronic Engineering"
            }
        ],
        "title": "An improved algorithm for sensor monitoring in WSANs",
        "abstract": "This paper presents an improved algorithm for sensor monitoring based on the algorithm proposed by Dilman et al. in [3]. By analyzing the probability of the alarm occurrence with the updated information, the proposed algorithm prolongs the interval between two consecutive polling periods when no alarm could occur. This method reduces the amount of monitoring traffic further than the method in [3] and still guarantees the detection of the alarm. The simulation results show that the proposed monitoring scheme reduces both the number of polling and the cost of the management of WSANs, consequently improves the performance. \u00a9 2011 IEEE.",
        "keywords": [
            "Policy",
            "Polling",
            "Sensor monitoring",
            "Trap"
        ],
        "venue": "Proceedings - 2011 International Conference on Network Computing and Information Security, NCIS 2011",
        "year": 2011,
        "id": "xNZ8IuHG"
    },
    "ELy2eEIh": {
        "authors": [
            {
                "name": "Jun-Hui Luo",
                "org": ""
            },
            {
                "name": "Hong-Bing Ji",
                "org": ""
            },
            {
                "name": "Li Jiang",
                "org": ""
            }
        ],
        "title": "Blind estimation of FN sequence of a direct sequence spread spectrum signal",
        "abstract": "An efficient method that can blindly estimate and synchronize to FN sequence of direct sequence spread spectrum (DS-SS) signal quickly is presented in a non-cooperative context. The method is based on the character of the DS-SS signal, firstly the period of PN sequence is estimated with a second-order cyclic-cumulant, and then the method of segmented cross-correlation is used to identify the synchronous start bit of the PN codes. The intercepted signal is divided into windows, from which the cross-correlation average is computed, and then the multiple correlations are utilized to estimate the PN sequence. Both theoretical analysis and simulations show that this method can get a good estimation without prior knowledge even if the intercepted signal is far below the noise, and it also has no hypothesis on the nature of the PN code sequence.",
        "keywords": [
            "Cycli-autocorrelation",
            "DS-SS signal",
            "PN code sequence",
            "Sequence period estimation"
        ],
        "venue": "Dianzi Keji Daxue Xuebao/Journal of the University of Electronic Science and Technology of China",
        "year": 2008,
        "id": "ELy2eEIh"
    },
    "Zqm9WHyP": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "Dept. of Electron. Info. and Eng."
            },
            {
                "name": "Dongsheng Zhang",
                "org": "Inst. of Modern Optics"
            },
            {
                "name": "Xingfa Dong",
                "org": "Inst. of Modern Optics"
            },
            {
                "name": "Guiyun Kai",
                "org": "Inst. of Modern Optics"
            },
            {
                "name": "Xiaoyi Dong",
                "org": "Inst. of Modern Optics"
            }
        ],
        "title": "Novel dual-wavelength fiber Bragg grating and its application in fiber ring laser",
        "abstract": "A novel method for fabricating dual-wavelength fiber Bragg gratings (FBGs) by using one phase mask was developed. The method is based on a double-exposure technique. Our technique lends itself to writing gratings with controllable reflectivity and separation of two Bragg wavelengths. A grating with two equal transmission peaks of 20.25 dB was obtained by this method and the separation of the two Bragg wavelengths is about 0.8 nm. With the grating, we demonstrate a dual-wavelength erbium-doped fiber ring laser whose interval of the two peaks is 0.8 nm. The laser's peak powers can get 3.1 mW above and have a good stability.",
        "keywords": [
            ""
        ],
        "venue": "Chinese Optics Letters",
        "year": 2004,
        "id": "Zqm9WHyP"
    },
    "OdAOABPE": {
        "authors": [
            {
                "name": "Dongsheng Zhang",
                "org": ""
            },
            {
                "name": "Guiyun Kai",
                "org": ""
            },
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Xiaoyi Dong",
                "org": ""
            }
        ],
        "title": "Fabricating fiber Bragg gratings with triangular spectrum using nonlinear double-exposure",
        "abstract": "A novel nonlinear double-exposure technique for fabricating fiber Bragg gratings with triangular spectrum is proposed. The spectrum of fiber Bragg grating can be controlled by double exposure technique. The first exposure is used to control the resonant wavelength of fiber grating by directly irradiating the naked photosensitive fiber. The second one is to form the grating to control its reflectivity through an ordinary Bragg phase mask. Considering the multi-decaying-exponential relationship between photo-induced index increment of photosensitive fiber and its irradiating dose, nonlinear double-exposure profiles are calculated by our self-designed software. The triangular fiber Bragg grating is obtained with DCS-01 photosensitive fiber by using a scanning system. As a result, the bottom width and the reflectivity of the grating is 1.24 nm and 0-64%, respectively. As a demodulation device, a triangular fiber Bragg gratings is very important in a fiber grating sensing system.",
        "keywords": [
            "Double-exposure",
            "Fiber grating",
            "N nonlinear",
            "Optoelectron optics",
            "Triangular fiber Bragg grating"
        ],
        "venue": "Guangzi Xuebao/Acta Photonica Sinica",
        "year": 2005,
        "id": "OdAOABPE"
    },
    "3Qcf8NZb": {
        "authors": [
            {
                "name": "Lin Li",
                "org": "School of Electronic Engineering, Xidian University"
            },
            {
                "name": "Li Jiang",
                "org": "School of Information and Control Engineering, Xi'an University of Architecture and Technology"
            }
        ],
        "title": "Recognition of polyphase coded signals using time-frequency rate distribution",
        "abstract": "Recognition of low probability of interception (LPI) radar signals is extremely important in electronic support measurement (ESM), or electronics intelligence (ELINT) systems. Polyphase codes including Frank, P1, P2, P3, and P4 code are a kind of LPI signals, which have been a new research hotspot in reconnaissance systems. In this paper, we propose a new recognition method for polyphase coded signals using the time-frequency rate (TFR) distribution. First we use the property of linear frequency modulation (LFM) to distinguish polyphase code from other LPI signals. Then we analyze the differences between polyphase code and LFM, and study the recognition feature of peak slice of the TFR. Finally we propose a hierarchical scheme for the recognition of polyphase coded signals. The simulation experiments results demonstrate that the proposed method has a high accurate recognition rate for various polyphase code, even under low signal to noise ratio (SNR). \u00a9 2014 IEEE.",
        "keywords": [
            "LFM",
            "Polyphase code",
            "signal recognition",
            "time-frquency rate distribution"
        ],
        "venue": "IEEE Workshop on Statistical Signal Processing Proceedings",
        "year": 2014,
        "id": "3Qcf8NZb"
    },
    "3sh35DoB": {
        "authors": [
            {
                "name": "Xingfa Dong",
                "org": "Univ. of Sci. and Technol. of Suzhou"
            },
            {
                "name": "Yonglin Huang",
                "org": "Univ. of Sci. and Technol. of Suzhou"
            },
            {
                "name": "Li Jiang",
                "org": "Inst. of Modern Optics"
            },
            {
                "name": "Guiyun Kai",
                "org": "Inst. of Modern Optics"
            },
            {
                "name": "Xiaoyi Dong",
                "org": "Inst. of Modern Optics"
            }
        ],
        "title": "Active temperature compensation design of sensor with fiber gratings",
        "abstract": "A technique for compensation of temperature effects in fiber grating sensors is reported. For strain sensors and other sensors related to strain such as electromagnetic sensors, a structure is designed, which uses two fiber Bragg gratings (FBGs) as strain differential sensor and has temperature effects cancelled. Using this technique, the stress sensitivity has been amplified and gets up to 0.226 nm/N, the total variation in wavelength difference within the range of 3-45\u00b0C is 0.03 nm, 1/14 of the uncompensated FBG. The structure can be used in the temperature-insensitive static strain measurement and minor-vibration measurement.",
        "keywords": [
            "Fiber Bragg grating",
            "Sensor",
            "Temperature compensation",
            "Vibration"
        ],
        "venue": "Chinese Optics Letters",
        "year": 2004,
        "id": "3sh35DoB"
    },
    "u7h1TbQp": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Xiangzheng Deng",
                "org": ""
            },
            {
                "name": "Karen C. Seto",
                "org": ""
            }
        ],
        "title": "The impact of urban expansion on agricultural land use intensity in China",
        "abstract": "China's urbanization has resulted in significant changes in both agricultural land and agricultural land use. However, there is limited understanding about the relationship between the two primary changes occurring to China's agricultural land - the urban expansion on agricultural land and agricultural land use intensity. The goal of this paper is to understand this relationship in China using panel econometric methods. Our results show that urban expansion is associated with a decline in agricultural land use intensity. The area of cultivated land per capita, a measurement about land scarcity, is negatively correlated with agricultural land use intensity. We also find that GDP in the industrial sector negatively affects agricultural land use intensity. GDP per capita and agricultural investments both positively contribute to the intensification of agricultural land use. Our results, together with the links between urbanization, agricultural land, and agricultural production imply that agricultural land expansion is highly likely with continued urban expansion and that pressures on the country's natural land resources will remain high in the future. \u00a9 2013 Elsevier Ltd.",
        "keywords": [
            "Agriculture",
            "Efficiency",
            "Land use change",
            "Multi-cropping index",
            "Off-farm opportunities",
            "Urban growth"
        ],
        "venue": "Land Use Policy",
        "year": 2013,
        "id": "u7h1TbQp"
    },
    "eWVNqhP4": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "School of Economics, Renmin University of China"
            },
            {
                "name": "Enjun Ma",
                "org": "School of Mathematics and Physics, China University of Geosciences (Wuhan)"
            },
            {
                "name": "Xiangzheng Deng",
                "org": "Center for Chinese Agricultural Policy, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences"
            }
        ],
        "title": "Impacts of irrigation on the heat fluxes and near-surface temperature in an inland irrigation area of Northern China",
        "abstract": "Irrigated agriculture has the potential to alter regional to global climate significantly. We investigate how irrigation will affect regional climate in the future in an inland irrigation area of northern China, focusing on its effects on heat fluxes and near-surface temperature. Using the Weather Research and Forecasting (WRF) model, we compare simulations among three land cover scenarios: the control scenario (CON), the irrigation scenario (IRR), and the irrigated cropland expansion scenario (ICE). Our results show that the surface energy budgets and temperature are sensitive to changes in the extent and spatial pattern of irrigated land. Conversion to irrigated agriculture at the contemporary scale leads to an increase in annual mean latent heat fluxes of 12.10 W m",
        "keywords": [
            "Climate change",
            "Energy budget",
            "Evaporative cooling",
            "Irrigated cropland",
            "Land management change",
            "Soil moisture"
        ],
        "venue": "Energies",
        "year": 2014,
        "id": "eWVNqhP4"
    },
    "lcaY4lCB": {
        "authors": [
            {
                "name": "Xin-Bo Zhang",
                "org": "College of Information and Electronic Engineering"
            },
            {
                "name": "Li Jiang",
                "org": "College of Information and Electronic Engineering"
            }
        ],
        "title": "Vehicle types recognition based on neural network",
        "abstract": "As a key technology of intelligent transportation system, higher identification accuracy, robustness and real-time are needed in vehicle recognition. Therefore, in view of the features of vehicle types, this paper proposes aBP neural network car types classifier method based on fuzzy C-means clustering. First, on the basis of the pretreatment of the images of the vehicle ,we abstract the features of car types from images and classify the massive dataes by fuzzy C- means clustering algorithm. Then, design the BP neural networks to train and test the classified data. Finally it is carried on compressive judgment by the computer. Experiments prove the validity of the classifier. It can recognize the highway vehicle types rapidly. \u00a9 2009 IEEE.",
        "keywords": [
            "BP algorithm",
            "Character abstraction",
            "Fuzzy c-means clustering"
        ],
        "venue": "Proceedings of the 2009 International Conference on Computational Intelligence and Natural Computing, CINC 2009",
        "year": 2009,
        "id": "lcaY4lCB"
    },
    "MVbe0SZ8": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University"
            },
            {
                "name": "Xuefeng Cui",
                "org": "State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University"
            },
            {
                "name": "Xia Xu",
                "org": "State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University"
            },
            {
                "name": "Yuan Jiang",
                "org": "State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University"
            },
            {
                "name": "Mark Rounsevell",
                "org": "School of GeoSciences, University of Edinburgh"
            },
            {
                "name": "Dave Murray-Rust",
                "org": "School of GeoSciences, University of Edinburgh"
            },
            {
                "name": "Yinghui Liu",
                "org": "College of Resources Science and Technology, Beijing Normal University"
            }
        ],
        "title": "A simple global food system model",
        "abstract": "In this study, we develop a simple dimension model to construct the food system in response to the population growth, the land use change and various socio-economic developments. The model simulates the consumption and production of agricultural goods in the individual countries, and maintains the global balance of food through the international trade flows between countries. Although there are some biases in the model results at the country levels, we suggest that such a simple model is feasible for simulating the global food supply system and assessing the uncertainties coming from various environmental and socio-economic factors.",
        "keywords": [
            "Consumption and production",
            "Food model",
            "Food trade"
        ],
        "venue": "Agricultural Economics (Czech Republic)",
        "year": 2014,
        "id": "MVbe0SZ8"
    },
    "mlXFwDyY": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "Dept. of Electron. Info. and Eng."
            },
            {
                "name": "Dongsheng Zhang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Jialin Zhong",
                "org": "Dept. of Electron. Info. and Eng."
            },
            {
                "name": "Xiaoyi Dong",
                "org": "Institute of Modern Optics"
            }
        ],
        "title": "A novel dual wavelength fiber Bragg grating and its application in dual-channel add-drop-multiplexer",
        "abstract": "We report a new method for writing the dual-wavelength Bragg fiber gratings. The method is based on the photosensitivity of Ge-doped optical fibers. Our double-exposure technique enables a good control over the grating's reflectivity and the separation of the two Bragg wavelengths. A grating with two equal transmission peak of 20.5dB is obtained by using this method and the separation of the two Bragg wavelengths is about 0.8 nm. With the grating, an optical add-drop multiplexer (OADM) that allows dropping two fixed wavelength channels is proposed.",
        "keywords": [
            "Dual-channel add-drop-multiplexer",
            "Dual-wavelength FBG",
            "Photosensitivity"
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2004,
        "id": "mlXFwDyY"
    },
    "LFJFI8dq": {
        "authors": [
            {
                "name": "Dong-Sheng Zhang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Li Jiang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Bo Liu",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Wei-Gang Zhang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Gui-Yun Kai",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Xiao-Yi Dong",
                "org": "Institute of Modern Optics"
            }
        ],
        "title": "A Novel Method for Measuring the Photo-Induced Birefringence of Photosensitive Fibres Based on a Fibre Loop",
        "abstract": "We report a novel method for measuring photo-induced birefringence of photosensitive fibres based on a fibre loop. The method is simple and is only slightly affected by the surroundings. The experimental results show that the photo-inducing normalized birefringence of the photosensitive fibre is multi-decaying-exponentially proportional to the exposure and it can attain 10",
        "keywords": [
            ""
        ],
        "venue": "Chinese Physics Letters",
        "year": 2003,
        "id": "LFJFI8dq"
    },
    "WnZv5QHj": {
        "authors": [
            {
                "name": "Kui Wang",
                "org": "Electrical Engineering School"
            },
            {
                "name": "Siyuan Wang",
                "org": "Electrical Engineering School"
            },
            {
                "name": "Gang Dong",
                "org": "Shandong Electrical Power Corporation"
            },
            {
                "name": "Li Jiang",
                "org": "Zibo Power Supply Company"
            },
            {
                "name": "Xin Zhang",
                "org": "Zibo Power Supply Company"
            },
            {
                "name": "Zhencun Pan",
                "org": "Electrical Engineering School"
            }
        ],
        "title": "Microprocessor-based multi-functional automation laboratory for power system",
        "abstract": "This paper describes a microprocessor-based multi-functional automation laboratory for power system. The details of the laboratory and its functions are presented. Especially, the principle of microprocessor-based excitation regulator and microprocessor-based full synchronizing control device are illustrated. Then a real power system can be simulated well through this novel laboratory. The laboratory not only make the students get familiar with the fundamentals of power system but make them learn how synchronous generators work and how they operate in a real power system. \u00a9 2006 IEEE.",
        "keywords": [
            "Excitation",
            "Experiment",
            "Full synchronizing control",
            "Multi-functional",
            "Power system",
            "Synchronous generator"
        ],
        "venue": "2006 1st IEEE Conference on Industrial Electronics and Applications",
        "year": 2006,
        "id": "WnZv5QHj"
    },
    "oBpmhXcm": {
        "authors": [
            {
                "name": "Chen Chao",
                "org": "Naval Academy of Armament"
            },
            {
                "name": "Zhou Jianjun",
                "org": "Naval Academy of Armament"
            },
            {
                "name": "Guo Wei",
                "org": "College of Information Science and Technology"
            },
            {
                "name": "Li Jiang",
                "org": "College of Information Science and Technology"
            },
            {
                "name": "He Jun",
                "org": "College of Information Science and Technology"
            },
            {
                "name": "Sun Bo",
                "org": "College of Information Science and Technology"
            }
        ],
        "title": "Research on an aerial-image multipurpose processing system based on C/S architecture",
        "abstract": "In the paper, aiming at mass-data aerial-images, a multipurpose system has been proposed. The system is based on c/s architecture design mode and supported by Oracle9i Database Server. On the implementation, C# .net technology has been adopted. In the process of image processing, several advanced international algorithms have been effectively amended and applied, like Retinex, SIFT, and Pyramid. With the system, many roles have been accomplished, such as authority management, automatically data input, image interpretation management, mass data maintenance, giant image process and annotation etc. \u00a92009 IEEE.",
        "keywords": [
            "Aerial image",
            "C/S",
            "Oracle9i",
            "Retinex",
            "SIFT"
        ],
        "venue": "ICEMI 2009 - Proceedings of 9th International Conference on Electronic Measurement and Instruments",
        "year": 2009,
        "id": "oBpmhXcm"
    },
    "Q1Ldrf3r": {
        "authors": [
            {
                "name": "Xin Zhang",
                "org": "Dept. of Electronic and Information"
            },
            {
                "name": "Yilin Chang",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Li Jiang",
                "org": "Dept. of Electronic and Information"
            },
            {
                "name": "Zhong Shen",
                "org": "State Key Lab. of Integrated Service Networks"
            }
        ],
        "title": "Analyzing fault monitoring policy for wireless nwtwork",
        "abstract": "The monitoring of a wireless network has a significant impact on the performance in that the bandwidths are constrained especially for the wireless channel. Efficient management assumes having reliable network monitoring information about the managed system. Based upon this point of view, a fault monitoring policy of hierarchical wireless network is proposed. It can be used to monitor the network in real time. With the application of the multi-agent Markov Decision Processes, an appropriate policy model of polling with the reinforcement learning is given. The simulation results show that with this MMDP model the network fault can be located fast and accurately and the overhead of network management decreased remarkably.",
        "keywords": [
            ""
        ],
        "venue": "GMC'2006: 2006 Global Mobile Congress - Papers",
        "year": 2006,
        "id": "Q1Ldrf3r"
    },
    "KcCmFsId": {
        "authors": [
            {
                "name": "Zhi Jing Xu",
                "org": "College of Information Engineering"
            },
            {
                "name": "Li Jiang",
                "org": "College of Information Engineering"
            },
            {
                "name": "Huan Lei Dai",
                "org": "College of Information Engineering"
            }
        ],
        "title": "A method of seabed soil image reconstruction based on Compressed Sensing",
        "abstract": "Compressed Sensing(CS) can project a high dimensional signal to a low dimensional signal by a random measurement matrix. As the projection calculation is time-consuming in the process of reconstruction, the reconstruction speed is greatly affected. In order to improve the reconstruction speed, some improvement in the selection of the measurement matrix and the design of the reconstruction algorithm is made. The wavelet transform is used to sparse decompose the image, and the very sparse random projection matrix is used as the measurement matrix, after the image block processing we use the OMP algorithm to reconstruct the image. The experimental result shows that this method could reduce the algorithm time and improved the reconstruction speed greatly. \u00a9 (2012) Trans Tech Publications.",
        "keywords": [
            "Compressed Sensing",
            "OMP algorithm",
            "Random projection",
            "Signal reconstruction"
        ],
        "venue": "Advanced Materials Research",
        "year": 2012,
        "id": "KcCmFsId"
    },
    "ct8quYdb": {
        "authors": [
            {
                "name": "Dong-Sheng Zhang",
                "org": "Center of Fiber Sensing Technology"
            },
            {
                "name": "Gui-Yun Kai",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Li Jiang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Xiao-Yi Dong",
                "org": "Institute of Modern Optics"
            }
        ],
        "title": "Study on the relationship between photo-induced index increment of photosensitive fiber and its dosed",
        "abstract": "To describe the relationship between photo-induced index increment \u0394n of photosensitive fiber and its dose the formula has been deduced based on a new assumption of the color-center model. The formula is in the form of multi-decaying exponential functions. The relationship between \u0394n of C",
        "keywords": [
            "Dose",
            "Index increment",
            "Optoelectron optics",
            "Photosensitive fiber"
        ],
        "venue": "Guangdianzi Jiguang/Journal of Optoelectronics Laser",
        "year": 2005,
        "id": "ct8quYdb"
    },
    "2vmxzCi1": {
        "authors": [
            {
                "name": "Dongsheng Zhang",
                "org": ""
            },
            {
                "name": "Guiyun Kai",
                "org": ""
            },
            {
                "name": "Ye Cao",
                "org": ""
            },
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Jianhua Luo",
                "org": ""
            },
            {
                "name": "Xiaoyi Dong",
                "org": ""
            }
        ],
        "title": "Novel fiber grating sensing and demodulating system with temperature compensation",
        "abstract": "The temperature characteristics of triangular fiber Bragg gratings have been studied theoretically and experimentally. The results show that the rate of resonant wavelength with temperature of the triangular fiber Bragg gratings is the same as that of ordinary fiber Bragg gratings, and the spectral shape of the grating can be kept without being affected by temperature. For the characteristics, a novel strain sensing and demodulating system with temperature compensation is designed. In the system, the wavelength code of strain is converted into the signal intensity, and the ratio of the signal intensity and the referent light intensity is used as the measuring value of strain. Theoretical and experimental researches indicate that the strain is proportional to the measurement value, and the system has the temperature compensation property. At three different temperature conditions, the strain test results of the cantilever experiments show that the measurement error of strain is less than 6 micro-strain/\u00b0C. For adopting the ratio of the signal intensity and the referent light intensity as the measuring value of strain, it avoids the effect to the test results coming from the flatness and fluctuating of the broad band light source.",
        "keywords": [
            "Fiber grating sensing",
            "Guided wave and fiber optics",
            "Strain measurement",
            "Temperature compensation",
            "Triangular fiber Bragg grating"
        ],
        "venue": "Guangxue Xuebao/Acta Optica Sinica",
        "year": 2005,
        "id": "2vmxzCi1"
    },
    "SRRS3aMA": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "School of Information and Control Engineering"
            },
            {
                "name": "Lin Li",
                "org": "School of Electronic Engineering"
            },
            {
                "name": "Guo-Qing Zhao",
                "org": "School of Electronic Engineering"
            }
        ],
        "title": "A novel method for LPI radar signal sorting in multipath channel",
        "abstract": "Signal sorting of low probability of interception (LPI) radar signals is extremely important in electronic support measurement (ESM) systems. Usually, there are multipath interferences in the intercepted signals, which result in the decrease of signal sorting performance of conventional methods. In this paper, we present a local ambiguity function (AF)-based signal sorting method for multipath fading environments. The singular vectors of the local AF are extracted as the signal feature which is robustness to the channel effects. Then, a multiclass classifier based on support vector machine (SVM) determines types of the received signals. Simulation results show that the proposed method has a high accurate rate for the recognition of twelve types of LPI radar signals in multipath channel, even at low signal to noise ratio (SNR). \u00a9 2012 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "IEEE International Symposium on Industrial Electronics",
        "year": 2012,
        "id": "SRRS3aMA"
    },
    "no2xyxm8": {
        "authors": [
            {
                "name": "Lin Li",
                "org": "School of Electronic Engineering"
            },
            {
                "name": "Hong-Bing Ji",
                "org": "School of Electronic Engineering"
            },
            {
                "name": "Li Jiang",
                "org": "School of Information and Control Engineering"
            }
        ],
        "title": "Incoherent scatter radar: High-speed signal acquisition and processing",
        "abstract": "The incoherent scatter radar (ISR) technique provides an efficient tool for measuring ionosphere parameters. These parameters are of important significance for radio communication and satellite navigation. Modern incoherent scatter radars rely on most complicated coding schemes to bring statistical accuracy to the measurements. In this paper, first we introduce a new hardware system for high-speed signal acquisition of ISR. Then two combination codes of alternating code and Barker code are presented which can facilitate full use of radar duty cycle and thus make the results accurate enough for analysis. The Barker-coded alternating code and the alternating-coded Barker code are suitable for E region and F region, respectively. Simulation experiment results demonstrate the validity of the presented methods. \u00a9 2012 IEEE.",
        "keywords": [
            ""
        ],
        "venue": "IEEE International Symposium on Industrial Electronics",
        "year": 2012,
        "id": "no2xyxm8"
    },
    "7WxS6JhP": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "School of Economics, Renmin University of China"
            },
            {
                "name": "Karen C. Seto",
                "org": "School of Forestry and Environmental Studies, Yale University"
            },
            {
                "name": "Junfei Bai",
                "org": "College of Economics and Management, China Agricultural University"
            }
        ],
        "title": "Urban economic development, changes in food consumption patterns and land requirements for food production in China",
        "abstract": "Purpose - The impact of dietary changes associated with urbanization is likely to increase the demand for land for food production. The purpose of this paper is to examine the impact of urban economic development on changes in food demand and associated land requirements for food production. Design/methodology/approach - Based on economic estimates from the Almost Ideal Demand System, feed conversion ratios, and crop yields, the authors forecast and compare future dietary patterns and land requirements for two types of urban diets in China. Findings - The results show that the expenditure elasticities of oil and fat, meat, eggs, aquatic products, dairy, and liquor for the diet of capital cities are greater than those for the diet of small- and medium-sized cities. The authors forecast that capital city residents will experience a more rapid rate of increase in per capita demand of meat, eggs, and aquatic products, which will lead to much higher per capita land requirements. Projections indicate that total per capita land demand for food production in capital cities will increase by 9.3 percent, from 1,402 to 1,533 m<sup>2</sup> between 2010 and 2030, while total per capita land demand in small- and medium-sized cities will increase only by 5.3 percent, from 1,192 to 1,255 m<sup>2</sup>. Originality/value - The results imply that urban economic development can significantly affect the final outcomes of land requirements for food production. Urban economic development is expected to accelerate the rate of change toward an affluent diet, which can lead to much higher future land requirements.",
        "keywords": [
            "Almost Ideal Demand System (AIDS)",
            "Cropland demand",
            "Dietary change",
            "Farmland loss",
            "Food security"
        ],
        "venue": "China Agricultural Economic Review",
        "year": 2015,
        "id": "7WxS6JhP"
    },
    "f4NTF6V5": {
        "authors": [
            {
                "name": "Xin-Bo Zhang",
                "org": "College of Information and Electronic Engineering"
            },
            {
                "name": "Li Jiang",
                "org": "College of Information and Electronic Engineering"
            }
        ],
        "title": "A new validity index of fuzzy c-means clustering",
        "abstract": "FCM algorithm is an important algorithm in fuzzy pattern identification. It has significant application value in theory and practice. And whether clustering results are reasonable or not is belongs to cluster validity problem. In this paper, based on the Shannon entropy and fuzzy variation theory, considering the geometry structure information of data sets, we give a new cluster validity function. Experimental results show that the new method has good classification performance. \u00a9 2009 IEEE.",
        "keywords": [
            "Fuzzy c-means",
            "Fuzzy variation",
            "Partition entropy",
            "Validity index"
        ],
        "venue": "2009 International Conference on Intelligent Human-Machine Systems and Cybernetics, IHMSC 2009",
        "year": 2009,
        "id": "f4NTF6V5"
    },
    "uWCE9ngH": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Dongsheng Zhang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Yonglin Huang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Weigang Zhang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Guiyun Kai",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Yiaoyi Dong",
                "org": "Institute of Modern Optics"
            }
        ],
        "title": "A novel dual-wavelength fiber bragg grating",
        "abstract": "We theoretically and experimentally demonstrate a novel dual-wavelength fiber Bragg grating fabricated using a double-exposure method. Our technique enables good control of the grating's reflectivity and separation of the two Bragg wavelengths. A grating with two equal transmission peaks of 20.5 dB is obtained with this method and the separation of the two Bragg wavelengths is about 0.8 nm. With this grating, an optical add-drop multiplexer (OADM) that allows dropping two fixed-wavelength channels is proposed. \u00a9 2005 Wiley Periodicals, Inc.",
        "keywords": [
            "Dual-wavelength fiber bragg grating",
            "OADM",
            "Photosensitivity"
        ],
        "venue": "Microwave and Optical Technology Letters",
        "year": 2005,
        "id": "uWCE9ngH"
    },
    "SDXoC2Zc": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Lin Li",
                "org": ""
            },
            {
                "name": "Hui Dong",
                "org": ""
            }
        ],
        "title": "An improved empirical mode decomposition method for multicomponent signal represntation",
        "abstract": "Empirical mode decomposition (EMD) is a local, fully data driven and self-adaptive analysis approach. It is a powerful tool for analyzing multi-component signals. Aiming at the reduction of scale mixing and artificial frequency components, an improved scheme was proposed for analysis and reconstruction of nonstationary and multicomponent speech signals. The improved EMD method uses higher order extrema and then the optimal envelope mean can be obtained with an inverse EMU scheme. A new sifting stop criterion was proposed based on the index of orthogonality. And finally, the mean square error criterion was used for performance evaluation. Experiments on simulated signals and actual sound signals proved the correctness and validity of the modified method. An exact decomposition result could be obtained using the improved EMD method with less scale mixing than using the standard EMD method. The proposed method has broad application potential in processing of speech signals, mechanical vibration signals and radar signals, etc.",
        "keywords": [
            "Empirical mode decomposition (EMD)",
            "Multicomponent signal",
            "Sifting stop criterion",
            "Speech signal"
        ],
        "venue": "Zhendong yu Chongji/Journal of Vibration and Shock",
        "year": 2009,
        "id": "SDXoC2Zc"
    },
    "K9W1rqOs": {
        "authors": [
            {
                "name": "Zhanglin Yang",
                "org": "School of Electronic and Information Engineering"
            },
            {
                "name": "Zhen Sun",
                "org": "School of Electronic and Information Engineering"
            },
            {
                "name": "Li Jiang",
                "org": "School of Electronic and Information Engineering"
            },
            {
                "name": "Yongping Xie",
                "org": "School of Electronic and Information Engineering"
            },
            {
                "name": "Hajime Kishida",
                "org": "Oki Data Corporation"
            }
        ],
        "title": "An area zoning based WLAN location system",
        "abstract": "In this paper, we present a wireless local area network (WLAN) indoor location system based on area zoning. The system estimates the zone where a mobile device resides by utilizing received signal strength indication (RSSI) from each access points (APs) and then calculates the mobile device's position. Experimental results show that the 25",
        "keywords": [
            "Area zoning",
            "Location",
            "RSSI",
            "WLAN"
        ],
        "venue": "IET Conference Publications",
        "year": 2009,
        "id": "K9W1rqOs"
    },
    "wf2GeBMs": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Dong-Sheng Zhang",
                "org": ""
            },
            {
                "name": "Wei-Gang Zhang",
                "org": ""
            },
            {
                "name": "Gui-Yun Kai",
                "org": ""
            },
            {
                "name": "Xiao-Yi Dong",
                "org": ""
            }
        ],
        "title": "Fabrication of dual-wavelength fiber Bragg grating with a longitudinal stretch",
        "abstract": "A method of fabricating dual-wavelength fiber Bragg grating with a uniform phase mask is demonstrated. Theoretical analysis and numerical simulation using Matrix method are given. The moving exposing technique is adopted. Good control over the grating's reflectivity and the separation of the two Bragg wavelengths is enabled by adjusting the stretch, the length of the grating, and the exposure. A grating with two equal transmission peaks of 19.5 dB is obtained by using this method, and the separation of the two Bragg wavelengths is 0.78 nm. \u00a9 Higher Education Press and Springer-Verlag 2006.",
        "keywords": [
            "Dual-wavelength fiber Bragg grating",
            "Fiber Bragg grating (FBG)",
            "Matrix method"
        ],
        "venue": "Frontiers of Physics in China",
        "year": 2006,
        "id": "wf2GeBMs"
    },
    "Ydn4Tjcc": {
        "authors": [
            {
                "name": "Xin Zhang",
                "org": "Dept. of Electronic and Information"
            },
            {
                "name": "Yi-Lin Chang",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Fang-Tao Sun",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Zhong Shen",
                "org": "State Key Lab. of Integrated Service Networks"
            },
            {
                "name": "Li Jiang",
                "org": "Dept. of Electronic and Information"
            }
        ],
        "title": "An improved algorithm for monitoring the network fault",
        "abstract": "Based on the hierarchical network architecture, we propose an improved dynamic monitoring algorithm for reducing the management overhead. By analyzing the probability of the alarm occurrece with the sampled network information, the proposed algorithm prolongs the interval between two consecutive pollings when no alarm could occur. This method significantly reduces the amount of monitoring traffic and guarantee to detect the abnormal event. The simulation results show that the proposed monitoring scheme reduces both the number of pollings and the cost of the network management, and consequently improves the network performance.",
        "keywords": [
            "Fault management",
            "Network monitoring",
            "Polling",
            "Trap"
        ],
        "venue": "Xi'an Dianzi Keji Daxue Xuebao/Journal of Xidian University",
        "year": 2006,
        "id": "Ydn4Tjcc"
    },
    "qbIoWLDH": {
        "authors": [
            {
                "name": "Li Jiang",
                "org": "Yale School of Forestry and Environmental Studies"
            },
            {
                "name": "Xiangzheng Deng",
                "org": "Center for Chinese Agricultural Policy"
            },
            {
                "name": "Karen C. Seto",
                "org": "Yale School of Forestry and Environmental Studies"
            }
        ],
        "title": "Multi-level modeling of urban expansion and cultivated land conversion for urban hotspot counties in China",
        "abstract": "China has undergone large-scale urban expansion and rapid loss of cultivated land for more than two decades. The goal of this paper is to examine the relative importance of socioeconomic and policy factors across different administrative levels on urban expansion and associated cultivated land conversion. We conduct the analysis for urban hotspot counties across the entire country. We use multi-level modeling techniques to examine how socioeconomic and policy factors at different administrative levels affect cultivated land conversion across three time periods, 1989-1995, 1995-2000, and 2000-2005. Our results show that at the county level, both urban land rent and urban wages contribute to total cultivated land conversion. Contrary to expectations, agricultural investment drives farmland conversion, suggesting a policy failure with unintended consequences. At the provincial level, urban wages and foreign direct investment both positively contribute to cultivated land conversion. We also find that higher GDP correlates with more urban expansion but the relationship is nonlinear. \u00a9 2012.",
        "keywords": [
            "County and provincial levels",
            "Farmland loss",
            "Longitudinal data",
            "Socioeconomic factors",
            "Urban land-use change",
            "Urbanization"
        ],
        "venue": "Landscape and Urban Planning",
        "year": 2012,
        "id": "qbIoWLDH"
    },
    "QBHCNbYm": {
        "authors": [
            {
                "name": "Xin-Bo Zhang",
                "org": ""
            },
            {
                "name": "Li Jiang",
                "org": ""
            }
        ],
        "title": "An imag segmentation algorithm based on fuzzy C-means clustering",
        "abstract": "Image segmentation algorithm based on fuzzy cmeans clustering is an important algorithm in the image segmentation field. It has been used widely. However, it is not successfully to segment the noise image because the algorithm disregards of special constraint information. It only considers the gray information. Therefore , we proposed a weighed fcm algorithm based on gaussian kernel function for image segmentation. The original euclidean distance is replaced by a kernel-induced distance in the algorithm. Then, a bound term is added to the objective function to compensate the influence of the spatial information. The experimental results illustrate that the proposed method is more effective to image segmentation. \u00a9 2009 IEEE.",
        "keywords": [
            "Fuzzy C-means",
            "Gaussian kernel function",
            "Image segmentation",
            "Weighted"
        ],
        "venue": "Proceedings - 2009 International Conference on Digital Image Processing, ICDIP 2009",
        "year": 2009,
        "id": "QBHCNbYm"
    },
    "G9HhoHBR": {
        "authors": [
            {
                "name": "Dong-Sheng Zhang",
                "org": "Fiber Optic Sensing Technol. Res. C."
            },
            {
                "name": "Li Jiang",
                "org": "Institute of Modern Optics"
            },
            {
                "name": "Qiu-Rong Ren",
                "org": "Modern Education Center"
            },
            {
                "name": "Jie Li",
                "org": "Fiber Optic Sensing Technol. Res. C."
            },
            {
                "name": "Ci-Ming Zhou",
                "org": "Fiber Optic Sensing Technol. Res. C."
            },
            {
                "name": "Sheng-Chun Liu",
                "org": "Fiber Optic Sensing Technol. Res. C."
            },
            {
                "name": "De-Sheng Jiang",
                "org": "Fiber Optic Sensing Technol. Res. C."
            },
            {
                "name": "Gui-Yun Kai",
                "org": ""
            },
            {
                "name": "Xiao-Yi Dong",
                "org": "Institute of Modern Optics"
            }
        ],
        "title": "Study on the photosensitivity of photosensitive fibers",
        "abstract": "The photosensitivity of photosensitive fibers is studied experimentally and theoretically. In the experiment, the relationship between the diffractive index increment of photosensitive fibers and UV irradiating dose based on an unbalanced Mach-Zehnder Interferometer (MZI) is measured. The experimental results show that the photo-induced index's increment of photosensitive fibers is multi-decaying-exponentially proportional to the UV irradiating dose and the order of magnitude of the maximum value can reach 10 ",
        "keywords": [
            "\"Kramers-Kronig\" principal",
            "Color center model",
            "Fiber grating",
            "Index increment",
            "Mach-Zehnder interferometer",
            "Multi-decaying-exponential",
            "Photosensitive fiber",
            "Photosensitivity",
            "UV irradiating time"
        ],
        "venue": "Proceedings of SPIE - The International Society for Optical Engineering",
        "year": 2004,
        "id": "G9HhoHBR"
    },
    "bO4qR3Yc": {
        "authors": [
            {
                "name": "Fang Yin",
                "org": ""
            },
            {
                "name": "Yihui Xiong",
                "org": ""
            },
            {
                "name": "Li Jiang",
                "org": ""
            },
            {
                "name": "Zhiguo Pang",
                "org": ""
            }
        ],
        "title": "Projected impacts of bioenergy-demand-induced land use and cover changes on regional climate in central europe",
        "abstract": "Energy shortfalls are becoming more and more serious all over the world, and worldwide governments have tried to promote the development of biofuels in order to mitigate the climatic impacts of massive fossil fuel consumption. Since the land is the main input factor of the bioenergy production, the development of biofuels will inevitably lead to change of the land use structure and allocation and thereby affect the climate system. With Central Europe as the study area, this study explored the impacts of land use/land cover change (LUCC) on climate under the influence of demand of bioenergy production for land resources. First, the land use structure from 2010 to 2050 is simulated with the Agriculture and Land Use model in MiniCam. The result indicates that the main conversion will be mainly from grassland and forest to cropland and from cropland to grassland. Then the Dynamics of Land System model was used to spatially simulate the LUCC in the future. The impacts of LUCC on the climate were analyzed on the basis of simulation with the Weather Research and Forecasting (WRF) model. The climate change will be characterized by the increase of latent heat flux and temperature and the decrease of precipitation. \u00a9 2013 Fang Yin et al.",
        "keywords": [
            ""
        ],
        "venue": "Advances in Meteorology",
        "year": 2013,
        "id": "bO4qR3Yc"
    },
    "3slxxKZb": {
        "authors": [
            {
                "name": "Yong Ding",
                "org": "School of Food Science and Technology"
            },
            {
                "name": "Qing Yang",
                "org": "School of Food Science and Technology"
            },
            {
                "name": "Wen-Qing Qi",
                "org": "School of Food Science and Technology"
            }
        ],
        "title": "Study on heparin immobilized with chitosan and its adsorption effect on low density lipoprotein",
        "abstract": "In this study, a novel heparin absorbent immobilized with chitosorn was synthesized, The adsorption effect of the immobilized heparin on triglyceride (TG) total cholesterd (TC) high-density lipoprotein (HDL) and low-density protein (LDL) in serum at 37\u00b0C was studied. Results showed that the adsorption rate to LDL and the best adsorption time was 50.8% and 150 min respectixely. It was also found that the heparin absorbent could decrease the content of TG. and TC in serum.",
        "keywords": [
            "Absorption rate",
            "Blood purification",
            "LDL"
        ],
        "venue": "Pharmaceutical Biotechnology",
        "year": 2009,
        "id": "3slxxKZb"
    },
    "brirFAVe": {
        "authors": [
            {
                "name": "Di Wu",
                "org": "City University of Hong Kong"
            },
            {
                "name": "S.W. Cheung",
                "org": "University of Hong Kong"
            },
            {
                "name": "T.I. Yuk",
                "org": "University of Hong Kong"
            },
            {
                "name": "X.L. Sun",
                "org": "University of Hong Kong"
            }
        ],
        "title": "A planar MIMO antenna for mobile phones",
        "abstract": "This paper presents a MIMO antenna using planar technology for mobile phone applications in the next generation. The antenna is composed of two identical monopoles printed on the ground plane of a one-sided printed-circuit board (PCB). A parasitic element is used in each monopole to increase the operating bandwidth. Simulation results show that the antenna can be used to cover the UMTS-2100 systems. By cutting two slits on the ground plane, isolation between the two monopoles can be greatly enhanced for the frequency band. The MIMO antenna has a planar structure, so it is low profile with low cost for mobile phone applications. Copyright \u00a9 2013 The Electromagnetics Academy.",
        "keywords": [
            ""
        ],
        "venue": "Progress in Electromagnetics Research Symposium",
        "year": 2013,
        "id": "brirFAVe"
    },
    "kPOEWycK": {
        "authors": [
            {
                "name": "Di Wu",
                "org": "Department of Electronic Engineering"
            },
            {
                "name": "S.W. Cheung",
                "org": "Department of Electronic Engineering"
            },
            {
                "name": "T.I. Yuk",
                "org": "Department of Electronic Engineering"
            },
            {
                "name": "L. Liu",
                "org": "Department of Electrical and Electronic Engineering"
            }
        ],
        "title": "Design of a printed multiband MIMO antenna",
        "abstract": "A multiband MIMO antenna using planar technology is proposed for next generation mobile communication system. The antenna consists of two symmetrical monopole elements printed in parallel to each other at the upper and lower corners of a printed-circuit board (PCB) with a size 50\u00d7110 mm",
        "keywords": [
            "isolation improvement",
            "LTE antenna",
            "MIMO antenna",
            "multiband antenna",
            "slit element",
            "smart phone antenna",
            "wideband antenna",
            "WiMAX",
            "WLAN"
        ],
        "venue": "2013 7th European Conference on Antennas and Propagation, EuCAP 2013",
        "year": 2013,
        "id": "kPOEWycK"
    },
    "QZaiXWK6": {
        "authors": [
            {
                "name": "Di Wu",
                "org": ""
            },
            {
                "name": "S.W. Cheung",
                "org": ""
            },
            {
                "name": "T.I. Yuk",
                "org": ""
            },
            {
                "name": "X.L. Sun",
                "org": ""
            }
        ],
        "title": "A MIMO antenna for mobile applications",
        "abstract": "A multiband Multiple-Input Multiple-Output (MIMO) antenna for mobile phones applications in the next generation is proposed. The proposed MIMO antenna consists of two identical elements, each having three branches to generate two frequency bands, a wide higher and narrow lower frequency bands. Simulation results show that these two frequency bands can cover the lower band for Long-Term Evolution (LTE), the DCS1800, PCS1900 and UMTS-2100 bands, the Wibro Band, the 2.4-GHz band for the WLAN system and also the upper band for the WiMAX. By cutting a slit on the printed circuit board (PCB) serving the ground plane, a great enhancement of isolation between the two antenna elements can be achieved for the two frequency bands. \u00a9 2013 IEEE.",
        "keywords": [
            "isolation",
            "Long-Term Evolution (LTE)",
            "MIMO antennas",
            "mobile terminals",
            "multiband antenna",
            "slit",
            "WiMax",
            "WLAN"
        ],
        "venue": "2013 International Workshop on Antenna Technology, iWAT 2013",
        "year": 2013,
        "id": "QZaiXWK6"
    },
    "s2IaNAAW": {
        "authors": [
            {
                "name": "Yi-Shan Wang",
                "org": "State Key Laboratory of Transient Optics and Technology"
            },
            {
                "name": "Hong-Jun Liu",
                "org": "State Key Laboratory of Transient Optics and Technology"
            },
            {
                "name": "Zhao Cheng",
                "org": "State Key Laboratory of Transient Optics and Technology"
            },
            {
                "name": "Wei Zhao",
                "org": "State Key Laboratory of Transient Optics and Technology"
            },
            {
                "name": "Yong-Gang Wang",
                "org": "Ultrafast Laser Laboratory"
            },
            {
                "name": "Xiao-Yu Ma",
                "org": "Institute of Semiconductors"
            },
            {
                "name": "Zhi-Gang Zhang",
                "org": "Ultrafast Laser Laboratory"
            }
        ],
        "title": "Self-starting mode-locked femtosecond Ti : sapphire laser using saturable Bragg reflector(SBR)",
        "abstract": "Stable self-starting mode-locking states in a compact Ti: sapphire laser incorporating a home-made SBR with low loss double quantum-well and low temperature and surface state hybrid absorber are investigated experimentally. The three mode-locking states, i.e. the passive mode-locking with a saturable absorber, the soliton mode-locking and the Kerr-lens mode-locking have been successfully demonstrated. In this laser, chirped mirrors are used for dispersion compensation, and the 18 fs pulses are produced from the Kerr-lens mode-locking at 4.5 W pump power, and output power is 150 mW.",
        "keywords": [
            "Chirped Mirror",
            "Femto-second",
            "Saturable Bragg reflector",
            "Ti:sapphire laser"
        ],
        "venue": "Wuli Xuebao/Acta Physica Sinica",
        "year": 2005,
        "id": "s2IaNAAW"
    },
    "Fnfa2vws": {
        "id": "Fnfa2vws",
        "title": "Study on Activation of Goat Oocytes and Parthenogenetic Embryos Development in Vitro",
        "abstract": "The present study was conducted to investigate activation of in vitro maturated goat follicular oocytes and parthenogenetic embryo development in vitro.The main results are as follows.The activation and development rates of 2.5 \u03bcmol/L,5.0 \u03bcmol/L and 10.0 \u03bcmol/L ionomycin were 54.0%,58.2%,57.9% and 1.5%,4.2%,0 respectively.There was no significant difference among all groups.The activation rates of 5.0 \u03bcmol/L,10.0 \u03bcmol/L,15.0 \u03bcmol/L and 20.0 \u03bcmol/L Ca-A23187 were 31.0%,46.4%,41.8% and 45.8% respectively.The activation rate of 5.0 \u03bcmol/L was significantly lower than that of other groups(P<0.05).The beyond 4-cell development rate of 5.0 \u03bcmol/L was significantly lower than that of 10.0 \u03bcmol/L and 20.0 \u03bcmol/L(P<0.01).The activation rates of 3%,7%, 11% and 15% ethanol were 40.0%,61.4%,63.0% and 67.9%,respectively.The activation rate of 3% ethanol was significantly lower than that of other groups(P<0.01),respectively.The death rate of 15% ethanol was 15.4%,and was significantly higher than that of other groups(P<0.05),respectively.2\uff5e8-cell development rates of 7% and 11% ethanol were significantly higher than that of 3% and 15%(P<0.05),respectively.Using the electronic pulse at different voltage 1.00,1.25,1.50 and 1.80 kV/cm in the electronic activation media including Ca2+ to stimulate the oocytes,the activation rates were 48.4%,54.3%,55.8% and 45.1%,respectively,with no significant difference(P>0.05).",
        "keywords": [
            "parthenogenetic activation",
            "goat",
            "oocytes",
            "in vitro maturation",
            "parthenogenetic embryo development"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Ji\u2032nan ,China"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Ji\u2032nan ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Ji\u2032nan ,China"
            },
            {
                "name": "LI Huan-ling",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Ji\u2032nan ,China"
            }
        ],
        "venue": "Journal of Jilin Agricultural University",
        "year": 2007
    },
    "gmF2aFF8": {
        "id": "gmF2aFF8",
        "title": "Effects of Granulosa Cells on in Vitro Maturation and in Vitro Fertilization of Goat Follicular Oocytes",
        "abstract": "The experiment was conducted to study the effects of granulosa cells on in vitro maturation(IVM) and in vitro fertilization(IVF) of goat follicular oocytes.The IVM rates of COCs\u3001denuded oocytes and naked oocytes were 68.3%,45.6% and 6.1% respectively.There was significant difference among all groups.The cleavage rates were 41.5%,8.1% and 0 respectively.The cleavage rates of COCs was significantly higher than that of denuded oocytes and naked oocytes.The IVM rates of oocytes cultured in control group,15\u00d710~4cell/ml and 150\u00d710~4cell/ml granulosa cells were 65.9%,60.2% and 64.6% respectively,and were significantly higher than that of 1 500\u00d710~4cell/ml(50.0%) and 1.5\u00d710~8 cell/ml(30.3%) granulosa cells groups.The maturation rate of oocytes in monolayer co-cultured medium was 75.8% and was significantly higher than that of 150\u00d710~4cell/ml and M199.The cleavage rate of oocytes in monolayer medium was 50.0% and was significantly higher than that of 150\u00d710~4 cell/ml and M199.",
        "keywords": [
            "Follicular oocyte",
            "Goat",
            "In vitro fertilization",
            "In vitro maturation",
            "Granulosa cell"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "LI Huan-ling",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "CUI Xu-kui",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            }
        ],
        "venue": "Shandong Agricultural Sciences",
        "year": 2006
    },
    "Ps7ea2QW": {
        "id": "Ps7ea2QW",
        "title": "Experiment on Superovulation and Embryo Translation of Dorper Sheep",
        "abstract": "s:The results indicated that the conception rates of the recipients transferredd single embryos and double embryos were 47.5% and 62.5% respectively,and there was significantly different(P<0.05).The conception rate of the recipients transferred was 54.2% in average.39 recipients were pregnant to term and 40 lambs were born,2.6 embryos born one lamb and one donor treated one time offered two kids in average.",
        "keywords": [
            "Dorper Sheep",
            "Embryo translation",
            "Superovulation"
        ],
        "authors": [
            {
                "name": "Wang Jin-wen",
                "org": "Institute of Animal Science and Veterinary MedicineShandong Academy of Agricultural Sciences,Shandong Jinan ,et al"
            },
            {
                "name": "Zhang Guo-ping",
                "org": "Institute of Animal Science and Veterinary MedicineShandong Academy of Agricultural Sciences,Shandong Jinan ,et al"
            },
            {
                "name": "Li Huan-ling",
                "org": "Institute of Animal Science and Veterinary MedicineShandong Academy of Agricultural Sciences,Shandong Jinan ,et al"
            }
        ],
        "venue": "China Herbivores",
        "year": 2006
    },
    "yyti6BMp": {
        "id": "yyti6BMp",
        "title": "Factors affecting superovulation in Dorpor sheep",
        "abstract": "To screen out the effect of age,embryo development stage,parities,repeated superovulation,time between supeovulation,recovered position,and season on superovulation in dorpor sheep,53 dorpor sheep were superovulated,the results demonstrated that the average recovered embryos of older 24 months sheep were significantly more than those of 8-12 months sheep(8.71\u22367.18)(P<0.05);and the vability rate of 8-12 months sheep were significantly more than that of 13-24 months sheep(95.29 %\u223675.96 %)(P<0.05).The average recovered embryos of later 2 parities were significantly more than those of first parity(8.71\u22367.00)(P<0.05);and the viability rat of first parity were significantly more than that of later 1 parities(96.14 %\u223675.88 %)(P<0.05).The average recovered embryos of third superovulated sheep were significantly lower than those of first and second superovulated donors(8.71\u22368.10\u22367.00)(P<0.05);and the average viable embryos of first superovulated sheep were significantly more than those of second and third superovulated donors(7.47\u22365.90\u22365.00)(P<0.05).The viability rate of 10 months between superovulation was significantly higher than that of 1 moth between superovulation(92.14 %\u223677.09 %)(P<0.05).The average recovered embryos from oviduct were significantly more than those from uerus corner(10.14\u22368.22)(P<0.05).The average viable embryos and viability rate of sheep superovulated in autumn were significantly higher those of sheep superovulated in autumn winter(7.53\u22365.97)(91.67 %\u223674.90 %)(P<0.05).",
        "keywords": [
            "dorpor sheep",
            "embryo",
            "superovulation",
            "embryos",
            "autumn",
            "embryonic development"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": "Anim.Sci.and Vet.Med.Insti.,Shandong Acad.of Agricu.Sci.,Shandong Jinan ,China"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Anim.Sci.and Vet.Med.Insti.,Shandong Acad.of Agricu.Sci.,Shandong Jinan ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Anim.Sci.and Vet.Med.Insti.,Shandong Acad.of Agricu.Sci.,Shandong Jinan ,China"
            },
            {
                "name": "LI Huan-ling",
                "org": "Anim.Sci.and Vet.Med.Insti.,Shandong Acad.of Agricu.Sci.,Shandong Jinan ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2008
    },
    "WxipuX4Z": {
        "id": "WxipuX4Z",
        "title": "Research and Production of Monoclonal Antibodies Avian Influenza Virus",
        "abstract": "The indirect ELISA was developed by using the purified MPAIV(Mildly Pathogenic Avian Influenza Virus)F strain as antigen and used to screen AIV monoclonal antibodies(McAbs).By using indirect ELISA and HI to screen hybridoma cells,and by using limiting dilution method to subclone positive clones three times,we acquired three positive clones.In Dot-ELISA,two McAbs could react with AIV H9N2 and H5N1,but neither could react with NDV,IBV,IBDV,EDSV-76,or with SPF chicken embryo allantoic fluid.The results suggested that these two McAbs were probably specific for the NP protein of AIV.Another McAb could react with AIV H9N2,but not react with AIV H5N1,NDV,IBV,IBDV,EDSV-76,or with SPF chicken embryo allantoic fluid.",
        "keywords": [
            "HI",
            "indirected ELISA",
            "Avian Influenza Virus",
            "monoclonal antibodies"
        ],
        "authors": [
            {
                "name": "HUANG Qing-hua",
                "org": "Institute of Veterinary and Animal Science,Shandong Academy of Agriculture Science,Jinan,Shandong ,China"
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Veterinary and Animal Science,Shandong Academy of Agriculture Science,Jinan,Shandong ,China"
            },
            {
                "name": "HU Bei-xia",
                "org": "Institute of Veterinary and Animal Science,Shandong Academy of Agriculture Science,Jinan,Shandong ,China"
            },
            {
                "name": "HUANG Yan-yan",
                "org": "Institute of Veterinary and Animal Science,Shandong Academy of Agriculture Science,Jinan,Shandong ,China"
            },
            {
                "name": "WANG Ke",
                "org": "Institute of Veterinary and Animal Science,Shandong Academy of Agriculture Science,Jinan,Shandong ,China"
            }
        ],
        "venue": "Acta Ecologiae Animalis Domastici",
        "year": 2010
    },
    "Z227Pzw1": {
        "id": "Z227Pzw1",
        "title": "Study on Development of Goat Transgenic-cloned Embryos Cultivated in Vivo and in Vitro",
        "abstract": "The effects of IVO/IVM oocytes,culture system in vivo/vitro,oviduct fluid,and co-culture with oviduct epithelia on the development of goat transgenic-cloned embryos were explored.The results demonstrated that there was no significant difference in the effect of matured oocytes in vivo/vitro on the development rate of transgenic-cloned embryos at all stages(P>0.05).There was no significant difference in development rate of 2\uff5e3-cell,4-cell,and 8-cell of transgenic-cloned embryos cultivated in vivo or in vitro(P>0.05).The 16-cell development and morula/blast rate of transgenic-cloned embryos cultivated in vivo were very higher than those of embryos cultivated in vitro(P<0.05).The development rate of 2\uff5e3-cell,4-cell,and 8-cell of transgenic-cloned embryos cultivated in control and 20% oviduct fluid was higher than that cultivated in 50% oviduct fluid(P<0.05).The development rate of 16-cell and morula/blast rate of transgenic-cloned embryos cultivated in 20% oviduct were higher than those cultivated in control and 50% oviduct fluid(P<0.05).There was no significant difference in development rate of 2\uff5e3-cell and 4-cell of transgenic-cloned embryos cultivated in SOF or in co-culture with oviduct epithelia(P>0.05).The development rate of 8-cell,16-cell and morula/ blast rate of transgenic-cloned embryos cultivated in co-culture with oviduct epithelia were higher than those cultivated in SOF(P<0.05).",
        "keywords": [
            "Co-culture system",
            "Oocyte",
            "Goat",
            "Transgenic-cloned embryo"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": ""
            },
            {
                "name": "HUANG Qing-hua",
                "org": ""
            },
            {
                "name": "WANG Ke",
                "org": ""
            },
            {
                "name": "WANG Jin-wen",
                "org": ""
            },
            {
                "name": "WANG De-qin",
                "org": ""
            }
        ],
        "venue": "Acta Agriculturae Jiangxi",
        "year": 2010
    },
    "f8DwdPS9": {
        "id": "f8DwdPS9",
        "title": "Studies on Meat Quality in Hybridized Lambs of Small-tail Han Sheep Crossed by Dorper,Suffolk and Polled Dorset Sheep",
        "abstract": "Selected total 20,4 each group,male lambs raised in the same condition and weighted 46~48.5kg(5~6month) in the experi ment.The results showed that crude protein content in meat of Suffolk\u00d7Small-tail Han SheepF1(SHF120.8%),Polled Dorset\u00d7Small-tail Han SheepF1(PDHF120.5%),and Dorper\u00d7Small-tail Han SheepF1(DHF120.1%),Small-tail Han Sheep(HH19.6%).Total content of 17 types amino acids was 20.9g,19.78g,and 19.13g and was higher than Small-tail Han Sheep(18.42g) respectively.Content of essential amino acids in human body of SHF1,PDHF1 and DHF1 increased 8.86%,8.54% and 2.16% than that HH respectively.Methionine and histidine content of DHF1 and PDH1 was significantly(P<0.05)higher than that of HH.Content of Asp and Glu directed relationship to special flavor of crossbred fat lamb was higher than that of HH.Content of crude fat of SHF1 and PDH F1 was higher than that of HH.Content of microelements Ca and Fe,Mn,Se was significantly(P<0.01)and(P<0.05)difference in different breed lamb meat.Content of SH and PDH lamb meat was highest.Content of Zn of HH lamb meat was 34mg and was higher than that of three hybrid groups.Poisonous and harmful elements were not checked out in four different breed lamb meat,it showed that ecology environments and forage conditions of lamb meat production all fulfilled green food and organic food requirements.By using Dorper,Suffolk and Polled Dorset sheep crossed Small-tail Han Sheep,not only the nutritive value of meat of hybrid sheep was enhanced,but also the special flavor was improved.Comprehensive evaluated nutritive value and meat character,crossbred lamb meat were all superior to that of Small-tail Han Sheep.",
        "keywords": [
            "microelements",
            "crossbred lamb",
            "Dorper",
            "Suffolk",
            "amino acids",
            "Polled Dorset Sheep",
            "meat character measurement",
            "chemical composition",
            "Small-tail Han Sheep"
        ],
        "authors": [
            {
                "name": "WANG Jin-wen",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "WANG De-qin",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "LI Huan-ling",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "CHEN Yong-lei",
                "org": "Animal Husbandry Bureau of Shiping County in Shandong provingce,Shiping,Shandong"
            },
            {
                "name": "ZHU Rong-sheng",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            }
        ],
        "venue": "Acta Ecologiae Animalis Domastici",
        "year": 2007
    },
    "gANMf0sl": {
        "id": "gANMf0sl",
        "title": "Mensuration of Productive Performance for Dorper sheep,Small-tail Han Sheep and Their Grossbred F_1",
        "abstract": "The experiment measured the productive performance for Dorper sheep,Small-tail Han sheep and their crossbred F_1.The results indicated that the birth weight of increased 22.27% and 34.03% than Dorper sheep and Small-tail Han Sheep respectively(P<0.01).During 0-60days the average daily gain weight of the crossbred F_1 increased 117g than Small-tail Han Sheep(P<0.01).The chest girth of the crossbred F_1 enhanced 0.13cm and 2.75cm than Dorper sheep and Small-tail Han Sheep from 0-12months respectively(P<0.05).Lambing rate of non-multifarious ewes enhanced 36.32% than that of Dorper sheep.Slaughtering percentage of 5-month the crossbred F_1 was 2.6% higher than that of Small-tail Han Sheep,and net meat rate was enhanced 10.93% than that of Small-tail Han Sheep.",
        "keywords": [
            "crossbred",
            "Dorper sheep",
            "mensuration",
            "Small-tail Han Sheep"
        ],
        "authors": [
            {
                "name": "LI Huan-ling",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            }
        ],
        "venue": "Acta Ecologiae Animalis Domastici",
        "year": 2006
    },
    "9rDFk04A": {
        "id": "9rDFk04A",
        "title": "Study on Heterosis Utilization of Dorpor Sheep with Small-tail Han Sheep",
        "abstract": "In order to study the effect of the same feed condition on growth performance and fertility of different hybrid populations,the crossbred F1,F2 and F3 of Dorpor sheep with small-tail Han sheep,Dorpor sheep and small-tail Han sheep(ram and ewe lambs)were split into several groups at random.The results indicated that the average birth weight of crossbred F1 was 3.91 kg and lower than that of the male parent(P>0.05);the average daily gain from birth to weaning was 318 g and higher than that of the female parent(P<0.01).In fattening period,the average daily gain of crossbred F1,F2 and F3 were 40.99%,26.13% and 22.52% respectively more than that of small-tail Han sheep(P<0.01);among the three crossbreds,the daily gain was similar and showed F1>F2>F3.The lamb rate of crossbred F1 was 40 percent points higher than that of Dorpor sheep,and the testing result of fecundity gene(FecB) was similar to the actual lamb number.The body weight,body high,body length and chest girth of the F1~F3 multiparous ewes were all higher than those of Dorpor sheep(P>0.05).The whole body conditions of crossbred F3 were superior to F1 and F2,so it was suggested that crossbred F1 should be used for fat lamb production,and crossbred F3 with FecB gene could be crossed with F2 ewes to breeding new Dorpor-Han mutton sheep.",
        "keywords": [
            "Heterosis",
            "Dorpor sheep",
            "Small-tail Han sheep",
            "Production performance",
            "Fecundity gene"
        ],
        "authors": [
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "CUI Xu-kui",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "YANG Pei-qi",
                "org": "Ningxia Tongxin White Goat Breeding Farm,Tongxin ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "LI Huan-ling",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "HUANG Qing-hua",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            }
        ],
        "venue": "Shandong Agricultural Sciences",
        "year": 2009
    },
    "6D8ZxSYW": {
        "id": "6D8ZxSYW",
        "title": "Effect of 6-Dimethylaminopurine on Activation and Development of In Vitro Matured Goat Oocytes Following Parthengogentic Stimulation",
        "abstract": "The present study was conducted to investigate the effect of 6-DMAP on parthenogenetic activation rate,pronuclear formation and in vitro parthenote development of in vitro matured goat oocytes.The activation rate of oocytes treated by ethanol or ionomycin combination with 6-DMAP was 75.6% and 71.1%,and higher than that of ethanol or ionomycin treated alone(54.3%,56.8;P<0.05).The percentage of activated oocytes with pronuclearfter ethanol or ionomycin combination with 6-DMAP was 90.3% and 96.3% higher than ethanol or ionomycin stimulation alone(26.3%,33.3%;P<0.05).Incubation with 6-DMAP following ethanol or ionomycin activation reduced the incidence of second polar body extrusion and significantly enhanced the proportion of oocytes with one polar body(Pb1) compared with ethanol or ionomycin activation alone.After 7 days of culture in vitro,the oocytes treated by ethanol or ionomycin in combination with 6-DMAP displayed significantly increased rates of 4-cell(45.6%,47.9%),8-cell(25.0%,29.6%) and blastocyst stages(7.4%,9.9%) compared with oocytes treated by ethanol or ionomycin alone(P<0.05).In conclusion,the major results of the present study clearly indicate that combined treatment of ethanol or ionomycin with 6-DMAP significantly increases parthenogenetic activation rate,pronuclear formation and in vitro parthenote development of in vitro matured goat oocytes.",
        "keywords": [
            "activation rate",
            "6-DMAP",
            "parthengogentic development",
            "pronuclear formation",
            "goat oocytes"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "LI Huan-ling",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            }
        ],
        "venue": "Journal of Jilin Agricultural University",
        "year": 2008
    },
    "JZNbwhHH": {
        "id": "JZNbwhHH",
        "title": "Breed Selection Research of Prolific Luxi Mutton Sheep with FecB Gene",
        "abstract": "During transvers cross phase of Luxi mutton sheep,4 rams(F2\u30013)with ideal type mated with 60 mix multiparous ewes(B+)carrying FecB and 70 wild multiparous ewes(F2\u30013) carrying gene(++).Determined their lambing rate,birth weight,weaning weight,body height,body length,chest girth and cannon circumference of Group.Result:Lambing rate of each group was 208.3% and 121.4% seperately,showed extreme difference(P<0.01);Birth weight of wild multiparous ewes(++) and mix one(B+) 85 lambs(Group ++) were 3.53kg and 4.74kg sepearately,the later one was raised 1.21 kg(34.27%),which was extremly different(P<0.01).The body height,body length,chest girth and cannon circumference of former group were higher than the later group,the difference is significant(P<0.05);3 months weaning weight of each group was 33.37 kg and 30.69 kg respectively,the difference is not significant,daily gain of weight and other body size data had no significant difference.The results indicated FecB gene is the main gene controling prolificacy of Luxi mutton sheep,this research build up the theory foundation for breeding prolific Luxi mutton sheep strain cultivation.",
        "keywords": [
            "weaning weight",
            "lambing rate",
            "birth weight",
            "body size",
            "FecB gene",
            "prolific breed"
        ],
        "authors": [
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            },
            {
                "name": "CUI Xu-kui",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            },
            {
                "name": "WANG Ke",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            },
            {
                "name": "HUANG Qing-hua",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            },
            {
                "name": "MENG Xian-feng",
                "org": "Institute of Animal Science and Veterinary Medicine,Agricultural Science Academy of Shandong province,Jinan,Shandong ,China"
            }
        ],
        "venue": "Acta Ecologiae Animalis Domastici",
        "year": 2010
    },
    "Xuyh1b9K": {
        "id": "Xuyh1b9K",
        "title": "Study on Hybrid Vigour of Small-tail Han Sheep Crossed by Dorper Sheep , Suffolk Sheep and Poul Dorset Sheep",
        "abstract": "The experiments selected total 54,10~12 each group, male lambs raised in the same conditions. The results showed that the average daily gains and ratio of feed to meat of Dorper\u00d7Small-tail Han Sheep F_1(DHF_1) in 5-6 months aged were 313g and 5.17 to 1 and were 12.59% and 10.71%, 14.23% and 12.82%, 10.99% and 16.34% significantly higher than those of Small-tail Han Sheep(HH), Suffolk\u00d7Small-tail Han SheepF_1(SHF_1), Polled Dorset\u00d7Small-tail Han Sheep F_1(PDHF_1)(P<0.05),respectively, and were 11.79% and 3.7% higher than those of Dorper\u00d7Small-tail Han SheepF_2(DHF_2). Dressing percent of DHF_1, DHF_2, SHF_1 and PDH F_1 increased 1.8,5.9,1.5 and 2.5 percentage than that of HH, respectively. Meat percentage of carcass was 4.6, 4.2, 3.1 and 3.1 percentage higher than that of HH. Eye muscle areas of DHF_1, DHF_2 and PDHF_1 were larger than that of HH (P<0.05) significantly. Marbling veins in meat was SHF_1>DHF_1>DHF_2>PDHF_1>HH. Shear value of eye muscle was DHF_2<PDHF_1<DHF_1<HH<SHF_1. Every one DHF_1 and DHF_2 increased 26 and 12.75 yuan more than that of every one HH.",
        "keywords": [
            "Dorper Sheep",
            "Suffolk Sheep",
            "meat character",
            "Dressing percent",
            "Poul Dorset Sheep",
            "average daily gain",
            "crossed fat lamb",
            "feed conversion rate",
            "Small-tail Han Sheep"
        ],
        "authors": [
            {
                "name": "Wang Jin-wen",
                "org": ""
            },
            {
                "name": "Zhang Guo-ping",
                "org": ""
            },
            {
                "name": "Wang De-qin",
                "org": ""
            }
        ],
        "venue": "China Herbivores",
        "year": 2006
    },
    "AsnyQavU": {
        "id": "AsnyQavU",
        "title": "Studies on Meat Quality of Hybridized Lambs Crossed Small-tail Han Sheep with Dorper,Suffolk and Polled Dorset Sheep",
        "abstract": "Selected total 20,4 each group,male lambs raised in the same condition and weighted 46~48.5kg(5~6month) in the experi ment.The results showed that crude protein content in meat of Suffolk\u00d7Small-tail Han SheepF1(SHF120.8%),Polled Dorset\u00d7Small-tail Han SheepF1(PDHF120.5%),and Dorper\u00d7Small-tail Han SheepF1(DHF120.1%),Small-tail Han Sheep(HH19.6%).Total content of 17 types amino acids was 20.9g,19.78g,and 19.13g and was higher than Small-tail Han Sheep(18.42g) respectively.Content of essential amino acids in human body of SHF1,PDHF1 and DHF1 increased 8.86%,8.54% and 2.16% than that HH respectively.Methionine and histidine content of DHF1 and PDH1 was significantly(P<0.05)higher than that of HH.Content of Asp and Glu directed relationship to special flavor of crossbred fat lamb was higher than that of HH.Content of crude fat of SHF1 and PDH F1 was higher than that of HH.Content of microelements Ca and Fe,Mn,Se was significantly(P<0.01)and(P<0.05)difference in different breed lamb meat.Content of SH and PDH lamb meat was highest.Content of Zn of HH lamb meat was 34mg and was higher than that of three hybrid groups.Poisonous and harmful elements were not checked out in four different breed lamb meat.Comprehensive evaluated nutritive value and meat character,crossbred lamb meat were all superior to that of Small-tail Han Sheep.",
        "keywords": [
            "microelements",
            "mutton amino acids",
            "fat lamb",
            "sheep"
        ],
        "authors": [
            {
                "name": "WANG Jin-wen",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "WANG De-qin",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "LI Huan-ling",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            },
            {
                "name": "CHEN Yong-lei",
                "org": "Animal Husbandry Bureau of Shiping County in Shandong provingce,Shiping,Shandong"
            },
            {
                "name": "ZHU Rong-sheng",
                "org": "Institutes of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan,Shandong ,china"
            }
        ],
        "venue": "Acta Ecologiae Animalis Domastici",
        "year": 2007
    },
    "ypfeOGvN": {
        "id": "ypfeOGvN",
        "title": "Factors Affecting Embryo Transfer in Dorpor Sheep",
        "abstract": "This study was conducted to investigate the effect of the number of transferred embryos,embryo development stage,repeated utilization of recipients,the number of corpus luteum in single ovary of recipients,season and transplantation methods on pregnancy rate and kidding in dorpor sheep.The results demonstrated that the pregnancy rate of recipients transferred two or three embryos(63.79% or 61.90%) was significantly higher than that of recipients transferred one embryo(50.30%)(P<0.05).There was no significant difference between the pregnancy rate of recipients transferred 2-8 cells and transferred morula /blast embryos.The effect of recipients repeated utilization on pregnancy rate was no significant difference(P>0.05).The pregnancy rate of recipients carrying three corpus luteums or even more in single ovary,was the highest,but compared to pregnancy rate of recipients carrying one or two corpus luteums,there was no significant difference(P>0.05).The pregnancy rate of recipients was 59.77% in winter,higher than that in autumn(52.94%),but no significant difference(P>0.05) was observed between them.The pregnancy rates of recipients were not significantly different(P>0.05)between surgical operation transfer and laoaroscope transfer.",
        "keywords": [
            "dorpor sheep",
            "pregnancy rate",
            "embryo transfer",
            "embryos"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "HUANG Qing-hua",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "ZHU Rong-sheng",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan ,China"
            },
            {
                "name": "XU Wei",
                "org": "Shandong Animal Husbandry and Veterinary Medicine Service,Jinan  China"
            }
        ],
        "venue": "Jiangsu Journal of Agricultural Sciences",
        "year": 2009
    },
    "RTEa95Jy": {
        "id": "RTEa95Jy",
        "title": "Introduction and Use of Frozen Embryo of Dorper Sheep",
        "abstract": "The frozen embr yos of Dorper sheep introduced from South Africa have been transferred and reproduced with the small-tail Han sheep as recipients.The performance,adaptation,reproduction and improvement of purebred Dorper sheep have been measured in Shandong for 7 years.The results showed that Purebred Dorper sheep born from the recipients of small-tail Han sheep reach the standard of Dorper sheep of South Africa in birth weight,average daily gain and reproductive rate.Dorper sheep has higher value in development and improvement of sheep industry in Shandong.As a fatting lamb productive paternal,Dorper sheep is a very ideal breed.",
        "keywords": [
            "embryo transfer",
            "pure reproduction",
            "Dorper sheep",
            "growth"
        ],
        "authors": [
            {
                "name": "LI Huan-ling",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            },
            {
                "name": "WANG Jin-wen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            },
            {
                "name": "ZHAO Hong-bo",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            },
            {
                "name": "WANG De-qin",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            },
            {
                "name": "ZHANG Guo-ping",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            },
            {
                "name": "LI Fa-chen",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            },
            {
                "name": "CUI Xu-kui",
                "org": "Institute of Animal Science and Veterinary Medicine,Shandong Academy of Agricultural Sciences,Jinan Shandong "
            }
        ],
        "venue": "Acta Ecologiae Animalis Domastici",
        "year": 2008
    },
    "6lCjQqUo": {
        "id": "6lCjQqUo",
        "title": "Effect of Cultured System and Cultured Time on Parthenogenetic Activation and Development of Goat Oocytes in Vitro",
        "abstract": "The effect of cultured time in vitro and culture systems on activation of goat oocytes and development in vitro was studied.The activation rates of oocytes in 36,33,30 and 27 h were very higher than that of 18,21 and 24 h.The activation rates of oocytes maturing in vitro 24 and 21 h were higher than that of 18 h.The 2-4-cell cleavage rates of parthenogenetic embryos of 27,30 and 33 h were very higher than that 18 h and higher than that of 21 h.The development rates of parthenogenetic embryos beyond 4-celll of 24,27 and 30 h were very higher than that of 21,33 and 36 h.The development rates of parthenogenetic embryos beyond 8-celll of 24,27 and 30 h were very higher than that of 21h.The development rates of parthenogenetic embryos beyond 16-celll of 24 and 27 h were very higher than that of 30 h.The development rates of parthenogenetic embryos cultured in TCM199 and SOF beyond 4-celll were lower than that of cultured in TCM199+GGC and SOF +GGC,and were very lower than that of cultured in TCM199+GOEC and SOF +GOEC,respectively.The development rates of parthenogenetic embryos cultured in TCM199+GGC and SOF +GGC beyond 8-celll and 16-cell were lower than that of cultured in TCM199+GOEC and SOF +GOEC.",
        "keywords": [
            "co-cultured systems",
            "goat",
            "parthenogenetic development",
            "oocytes",
            "parthenogenetic activation",
            "parthenogenesis",
            "embryonic development",
            "embryos",
            "in vitro fertilization"
        ],
        "authors": [
            {
                "name": "ZHANG Guo-ping",
                "org": "Animal Science and Veterinary Medical Institute,Shandong Academy of Agricultural Sciences,Shandong Jinan ,China"
            },
            {
                "name": "WANG Jin-wen",
                "org": "Animal Science and Veterinary Medical Institute,Shandong Academy of Agricultural Sciences,Shandong Jinan ,China"
            },
            {
                "name": "WANG De-qin",
                "org": "Animal Science and Veterinary Medical Institute,Shandong Academy of Agricultural Sciences,Shandong Jinan ,China"
            },
            {
                "name": "HUANG Qing-hua",
                "org": "Animal Science and Veterinary Medical Institute,Shandong Academy of Agricultural Sciences,Shandong Jinan ,China"
            },
            {
                "name": "ZHU Rong-sheng",
                "org": "Animal Science and Veterinary Medical Institute,Shandong Academy of Agricultural Sciences,Shandong Jinan ,China"
            },
            {
                "name": "XU Wei",
                "org": "Shandong Animal Husbandry and Veterinary Medical Service&amp,Shandong Jinan ,China"
            }
        ],
        "venue": "Southwest China Journal of Agricultural Sciences",
        "year": 2009
    },
    "zSjNsmXm": {
        "id": "zSjNsmXm",
        "title": "Hierarchical synthesis of non-centrosymmetric hybrid nanostructures and enabled plasmon-driven photocatalysis",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "lin weng",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "min ouyang",
                "org": ""
            }
        ],
        "venue": "Nature Communications",
        "year": 2014
    },
    "syNEW6HA": {
        "id": "syNEW6HA",
        "title": "Theory of Quantum Plasmon Resonances in Doped Semiconductor Nanocrystals",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "peter nordlander",
                "org": ""
            },
            {
                "name": "emil prodan",
                "org": ""
            },
            {
                "name": "vikram kulkarni",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2014
    },
    "LAFPsweG": {
        "id": "LAFPsweG",
        "title": "Optical Generation of Hot Plasmonic Carriers in Metal Nanocrystals: The Effects of Shape and Field Enhancement",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2014
    },
    "9kIRok1A": {
        "id": "9kIRok1A",
        "title": "Photogeneration of hot plasmonic electrons with metal nanocrystals: Quantum description and potential applications",
        "abstract": "",
        "keywords": [
            "photodetectors",
            "photoelectric effect",
            "photocatalysis",
            "plasmon",
            "nanostructures"
        ],
        "authors": [
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "hilmi volkan demir",
                "org": ""
            },
            {
                "name": "yurii k gun ko",
                "org": ""
            }
        ],
        "venue": "Nano Today",
        "year": 2014
    },
    "B7QflZWE": {
        "id": "B7QflZWE",
        "title": "Exciton recombination dynamics in type II CdTe-Cu 2-x Te nano heterostructures with excitonic and plasmonic properties",
        "abstract": "",
        "keywords": [
            "nanomaterials"
        ],
        "authors": [
            {
                "name": "ilka kriegel",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "andreas wisnet",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "ajay r kandada",
                "org": "polytechnic university of milan"
            },
            {
                "name": "francesco scotognella",
                "org": "instituto politecnico nacional"
            },
            {
                "name": "francesco tassone",
                "org": "polytechnic university of milan"
            },
            {
                "name": "christina scheu",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "hui zhang",
                "org": "ohio university"
            },
            {
                "name": "alexander o govorov",
                "org": "ohio university"
            },
            {
                "name": "jessica rodriguezfernandez",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "jochen feldmann",
                "org": "ludwig maximilian university of munich"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "JXOv8zu4": {
        "id": "JXOv8zu4",
        "title": "Reconfigurable 3D plasmonic metamolecules",
        "abstract": "",
        "keywords": [
            "nanoparticles"
        ],
        "authors": [
            {
                "name": "anton kuzyk",
                "org": "max planck institute for intelligent systems"
            },
            {
                "name": "r schreiber",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": "ohio university"
            },
            {
                "name": "alexander o govorov",
                "org": "ohio university"
            },
            {
                "name": "tim liedl",
                "org": ""
            },
            {
                "name": "na liu",
                "org": "max planck institute for intelligent systems"
            }
        ],
        "venue": "Nature Materials",
        "year": 2014
    },
    "VeF8HhA1": {
        "id": "VeF8HhA1",
        "title": "Shedding Light on Vacancy-Doped Copper Chalcogenides: Shape-Controlled Synthesis, Optical Properties, and Modeling of Copper Telluride Nanocrystals with Near-Infrared Plasmon Resonances",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "christian waurisch",
                "org": ""
            },
            {
                "name": "j feldmann",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "ilka kriegel",
                "org": ""
            },
            {
                "name": "aliaksei dubavik",
                "org": ""
            },
            {
                "name": "alexander eychmuller",
                "org": ""
            },
            {
                "name": "jessica rodriguezfernandez",
                "org": ""
            },
            {
                "name": "andreas wisnet",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            }
        ],
        "venue": "ACS Nano",
        "year": 2013
    },
    "8tiZUDTL": {
        "id": "8tiZUDTL",
        "title": "Cation exchange synthesis and optoelectronic properties of type II CdTe-Cu2-xTe nano-heterostructures",
        "abstract": "",
        "keywords": [
            "physics",
            "discrete dipole approximation"
        ],
        "authors": [
            {
                "name": "ilka kriegel",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "andreas wisnet",
                "org": ""
            },
            {
                "name": "ajay ram srimath kandada",
                "org": ""
            },
            {
                "name": "francesco scotognella",
                "org": "instituto politecnico nacional"
            },
            {
                "name": "francesco tassone",
                "org": ""
            },
            {
                "name": "christina scheu",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "hui zhang",
                "org": "ohio university"
            },
            {
                "name": "alexander o govorov",
                "org": "ohio university"
            },
            {
                "name": "j rodriguezfernandez",
                "org": "ludwig maximilian university of munich"
            },
            {
                "name": "j feldmann",
                "org": "ludwig maximilian university of munich"
            }
        ],
        "venue": "",
        "year": 2014
    },
    "xHzODc01": {
        "id": "xHzODc01",
        "title": "Plasmon Resonances and Size-Quantization Effects in Doped Semiconductor Nanocrystals",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "vikram kulkarni",
                "org": ""
            },
            {
                "name": "emil prodan",
                "org": ""
            },
            {
                "name": "peter nordlander",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "vAGyxsJN": {
        "id": "vAGyxsJN",
        "title": "Theory of Photoinjection of Hot Plasmonic Carriers from Metal Nanostructures into Semiconductors and Surface Molecules",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "yurii k gun ko",
                "org": ""
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2013
    },
    "Whi1wlLG": {
        "id": "Whi1wlLG",
        "title": "A Reconfigurable 3D Plasmonic Nanomachine",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "tim liedl",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "robert schreiber",
                "org": ""
            },
            {
                "name": "anton kyzyk",
                "org": ""
            },
            {
                "name": "laura na liu",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "WNAV45nV": {
        "id": "WNAV45nV",
        "title": "Chiroptical Activity in Silver Cholate Nanostructures Induced by the Formation of Nanoparticle Assemblies",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "gil markovich",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "muriel e layani",
                "org": ""
            },
            {
                "name": "assaf ben moshe",
                "org": ""
            },
            {
                "name": "maxim varenik",
                "org": ""
            },
            {
                "name": "oren regev",
                "org": ""
            }
        ],
        "venue": "Journal of Physical Chemistry C",
        "year": 2013
    },
    "uezDjqkn": {
        "id": "uezDjqkn",
        "title": "Dipole and Quadrupole Plasmon Resonances in Gold Nanoring Structures",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "larousse khosravi khorashad",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "evamaria roller",
                "org": ""
            },
            {
                "name": "tim liedl",
                "org": ""
            },
            {
                "name": "alexander o govorov",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2014
    },
    "lZNTXi7T": {
        "id": "lZNTXi7T",
        "title": "Theory of photo-injection of hot plasmonic carriers in metal-semiconductor nanostructures",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "alexander o govorov",
                "org": ""
            },
            {
                "name": "hui zhang",
                "org": ""
            },
            {
                "name": "yurii k gounko",
                "org": ""
            }
        ],
        "venue": "",
        "year": 2013
    },
    "UPYRGGeK": {
        "authors": [
            {
                "name": "Kun-Peng Li",
                "org": "Research Center of Pathophysiology"
            },
            {
                "name": "Xiu-Rong Huang",
                "org": "Research Center of Pathophysiology"
            },
            {
                "name": "Ming-Xin Qi",
                "org": "Department of Ophthalmology"
            },
            {
                "name": "Yi Chen",
                "org": "Research Center of Pathophysiology"
            }
        ],
        "title": "Distribution of new biological activity substance Urotensin-II in tissues of human eye",
        "abstract": "AIM: To study the distribution of Urotensin- II (U- II), a new biological activity substance in tissues of human eye. METHODS: The different tissues of normal fresh human eye were separated and homogenized, then the distributions of U- II were measured by radio-immunoassay. RESULTS: There were distributions of U- II in any tissues of human eye, ranging 0.807-32.958ng/g. The U-II content in optic nerve was the highest(32.958 \u00b11.741 ng/g), then sclera, iris, cornea, ciliary body, choroid, retina and lens in turn. The U- II content in vitreous body and aqueous humor were the lowest. The U- II content in optic nerve was 40.4 times of that in aqueous humor. CONCLUSION: U- II is distributed in tissues of human eye widely. Its effects of physiology and pathophysiology need to further study.",
        "keywords": [
            "Distribution",
            "Human eye",
            "Urotensin II"
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2011,
        "id": "UPYRGGeK"
    },
    "64H7mLX7": {
        "authors": [
            {
                "name": "Xiu-Rong Huang",
                "org": "Research Centre of Pathophysiology"
            },
            {
                "name": "Ming-Xin Qi",
                "org": "Research Centre of Pathophysiology"
            },
            {
                "name": "Zhao-Yang Wang",
                "org": "Research Centre of Pathophysiology"
            },
            {
                "name": "Yi Chen",
                "org": "Research Centre of Pathophysiology"
            }
        ],
        "title": "Inhibition effects of compound leech eye drops on apoptosis of lens epithelial and expressions of Bcl-2 Bax genes in rats",
        "abstract": "Objective: To investigate the inhibition effects of compound leech eye drops (Co-SZ) on apoptosis of lens epithelial cells (LECs) induced by hydrogen peroxide (H",
        "keywords": [
            "Apoptosis",
            "Cataract",
            "Epithelial cells",
            "Genes",
            "Leeches"
        ],
        "venue": "Journal of Chinese Integrative Medicine",
        "year": 2007,
        "id": "64H7mLX7"
    },
    "ojGwDiFt": {
        "authors": [
            {
                "name": "Xiu-Rong Huang",
                "org": ""
            },
            {
                "name": "Ming-Xin Qi",
                "org": ""
            },
            {
                "name": "Kun-Peng Li",
                "org": ""
            },
            {
                "name": "Yi Chen",
                "org": ""
            }
        ],
        "title": "Experimental study on proliferation induced by urotensin II in lens epithelial cell",
        "abstract": "Aim: To study the effect of urotensin II ( U-II ,a new biological activity substance on proliferation of lens epithelial cell(LEC). Methods; Different concentrations of U-II were incubated with in vitro cultured LEC in vitro. The activities of LEC were detected via methyl thiazolyl tetrazolium (MTT). The proliferations of LEC were detected via ",
        "keywords": [
            "After cataract",
            "Lens epithelial cell",
            "Proliferation",
            "Urotensin II"
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2010,
        "id": "ojGwDiFt"
    },
    "MogjXnJ5": {
        "authors": [
            {
                "name": "Xiu-Rong Huang",
                "org": "Research Centre of Pathophysiology"
            },
            {
                "name": "Ming-Xin Qi",
                "org": "Department of Ophthalmology"
            },
            {
                "name": "Kun-Peng Li",
                "org": "Research Centre of Pathophysiology"
            },
            {
                "name": "Yi Chen",
                "org": "Research Centre of Pathophysiology"
            }
        ],
        "title": "Mechanism on signal transduction of proliferation induced by urotensin II in lens epithelial cell",
        "abstract": "Aim: To study the mechanism on signal transduction of proliferation induced by urotensin-II( U-II ) in lens epithelial cell(LEC). Methods: U-II were incubated with cultured LEC. Meanwhile four blockers of signal transduction, H",
        "keywords": [
            "After cataract",
            "Lens epithelial cell",
            "Proliferation",
            "Signal transduction",
            "Urotensin II"
        ],
        "venue": "International Journal of Ophthalmology",
        "year": 2010,
        "id": "MogjXnJ5"
    },
    "gUGe25f9": {
        "authors": [
            {
                "name": "Mingwei Shen",
                "org": ""
            },
            {
                "name": "Liu Yang",
                "org": ""
            },
            {
                "name": "Di Wu",
                "org": ""
            },
            {
                "name": "Daiyin Zhu",
                "org": ""
            }
        ],
        "title": "Multichannel SAR wide-swath imaging based on adaptive removal of azimuth ambiguities",
        "abstract": "By exploiting the direction of arrival (DoA) information of azimuth ambiguity, an innovative algorithm for the adaptive suppression of azimuth ambiguity for multichannel synthetic aperture radar (SAR) wide-swath imaging is presented. It firstly estimates the DoA value of each azimuth component within a Doppler cell using the efficient noise subspace-based iterative estimation technique. Then the spatial filter for sequentially extracting the desired azimuth component is derived, which is designed to be used with the newly estimated DoA information within each Doppler bin. Finally, the azimuth ambiguities can be suppressed via the implementation of spatial filtering. The proposed approach is robust to aircraft velocity errors, and its effectiveness is validated via simulation results.",
        "keywords": [
            ""
        ],
        "venue": "Remote Sensing Letters",
        "year": 2015,
        "id": "gUGe25f9"
    },
    "LPEx5Pi5": {
        "authors": [
            {
                "name": "Dnjun Wang",
                "org": "Dept. of Mechanics and Engineering Science"
            },
            {
                "name": "C.-C. Wang",
                "org": "Dept. of Mechanical Engineering and Materials Science"
            }
        ],
        "title": "Natural vibrations of repetitive structures",
        "abstract": "Natural vibration frequencies and modes of repetitive structures, including symmetric, periodic, linking structures, are considered in this work. By using the repetition of the identical parts, we reduce the eigenvalue problem of the structure to a set of eigenvalue problems of lower dimensions associated with the parts. Special forms and properties of the modes of natural vibrations are observed.",
        "keywords": [
            "Eigenvalue problem",
            "Linking structures",
            "Modes",
            "Natural vibrations",
            "Periodic structures",
            "Repetitive structures",
            "Symmetric structures"
        ],
        "venue": "Journal of Mechanics",
        "year": 2000,
        "id": "LPEx5Pi5"
    },
    "vgo1OcmN": {
        "id": "vgo1OcmN",
        "title": "Discussion on the Teaching Method of Fourier Transform Properties",
        "abstract": "The Fourier transform of continuous-time signals is an important content in Signals and Systems course.And the property of the Fourier transform is the emphasis.Firstly,the relations of the Fourier transform properties are analysed.Secondly,a teaching method is put forward,in which the relation of time domain and frequency domain is emphasized,the scalling property is professed firstly,and the physical meanings of properties are explained as emphasis.Lastly,the methods of derivation one another are given using symmetry property.",
        "keywords": [
            "signals and systems",
            "scalling property",
            "symmetry property",
            "Fourier transform"
        ],
        "authors": [
            {
                "name": "DAN Mei",
                "org": "National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "CAO Ju-liang",
                "org": "National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WU Jing",
                "org": "National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electrical & Electronic Education",
        "year": 2013
    },
    "jshAhtE1": {
        "id": "jshAhtE1",
        "title": "Data Association and Track Management in Multitarget Tracking",
        "abstract": "There are two drawbacks in the conventional multitarget association algorithm JPDA : large computation cost and lacking the logic for the track's initiation and termination in the framework.The paper develops a track management schedule,which includes several association algorithms in different circumstances.In addition,an improved fast association algorithm MPDA is proposed,which considers the effect of public measurements to the trajectories' update.MPDA can approach the association performance of JPDA with the computation cost as much as PDAF.The simulation results show that the proposed method can maintain high tracking success ratio in complicated circumstance.",
        "keywords": [
            "tracking management",
            "multitarget tracking",
            "data association",
            "MPDA"
        ],
        "authors": [
            {
                "name": "ZHAO Yan-li",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "LIN Hui",
                "org": "Post Box 061,Luoyang ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "WANG Guo-yu",
                "org": "Post Box 061,Luoyang ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2007
    },
    "XqBWFBft": {
        "id": "XqBWFBft",
        "title": "Calculation Model for Aeroplane IR Signature and Atmospheric Attenuation Along the Line of Sight",
        "abstract": "The algorithm of infrared signature of aeroplane along the line of sight is studied.Three infrared radiation sources of the aeroplane are researched: skin,spout and plume.The model of infrared signature of aeroplane along the line of sight is proposed.According to the propagation of infrared radiation in atmosphere,the attenuation effects of atmosphere absorbing,dispersion and meteorological attenuation are analyzed,then a calculation method for the propagation in atmosphere is introduced.Finally an example of the calculation model is given.",
        "keywords": [
            "atmospheric attenuation",
            "calculation model",
            "aeroplane",
            "infrared signature"
        ],
        "authors": [
            {
                "name": "ZHANG Liang",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Infrared Technology",
        "year": 2011
    },
    "paROkbCr": {
        "id": "paROkbCr",
        "title": "Detection of Multiple Unresolved Targets Based on Range Information Using Hybrid Bistatic Radar",
        "abstract": "Detection of multiple unresolved targets is a frontier topic and pressing task in radar technology field.A signal fusion method of the T/R-R hybrid bistatic radar is presented,target echo signal models of the monostatic radar receiver and the bistatic radar receiver are established,aiming at two-dimensional plane situation,the signal fusion model is presented based on range information and used to detect multiple unresolved targets with maximum likelihood method,and the effects of SNR,number of targets,target fluctuation, detection threshold and hybrid bistatic radar geometrical configuration on the detection performance are analyzed.The Monte Carlo simulation results based on different scenarios identify the validity of the method.By theoretical analysis and simulation experiments, ranges between targets and both receivers,interference from the targets in the different range bins merely affect the detection performance, the primary factors which affect the detection performance consist of SNR,number of targets,target fluctuation,interference from the angle unresolved targets in the same range bins and detection threshold;and that the detection method is presented under the assumed condition of Swerling\u2161target,but it is still suitable for Swerling 0 and\u2161target.",
        "keywords": [
            "range information",
            "detection",
            "hybrid bistatic radar",
            "multiple unresolved targets"
        ],
        "authors": [
            {
                "name": "MIN Tao",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Signal Processing",
        "year": 2011
    },
    "Zpm8Vi4d": {
        "id": "Zpm8Vi4d",
        "title": "Analysis of Phased Array Radar System Simulation Parallel Procession Based on HLA",
        "abstract": "On the basis of the analysis of phased array radar system coherent video simulation and High Level Architecture(HLA),the simulation method of phased array radar system parallel process based on HLA/RTI was proposed.,which enabled the simulation to run on the multiple flats and processors so as to enhance its run-time efficiency.The simulation result identifies its feasibility and validity.",
        "keywords": [
            "parallel process",
            "phased array radar",
            "HLA/RTI",
            "simulation"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Yan-li",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2006
    },
    "oYJExL0g": {
        "id": "oYJExL0g",
        "title": "Research on Computation Model of Radar Target Detection Probability with Noise Interference",
        "abstract": "The relationship between detection probability and Jamming is analyzed.Associating with radar's parameter,the expression of calculating detection probability in jamming is gained.Combined with the rank \"K\" principle,the expression of radar network's detection probability in noise jamming is gained.The problem of radar network's detection probability is resolved.Simulation results verify the validity of the model and method.",
        "keywords": [
            "noise jamming",
            "jamming power",
            "radar network",
            "detection probability"
        ],
        "authors": [
            {
                "name": "HE Zhi-qiang",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China;PLA,No.61251 Troop,Hebei Qinhuangdao ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "ZHAO Bang-xu",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China;PLA,Military deputation at Guangyuan,Sichuan Guangyuan ,China"
            },
            {
                "name": "LIU Zhong",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            }
        ],
        "venue": "Modern Defence Technology",
        "year": 2012
    },
    "N82Odxb3": {
        "id": "N82Odxb3",
        "title": "The Derivation and Applicability Investigation of Radar Target Height Formula",
        "abstract": "The target height formula has been derivated in details through Tailor expandedness in this paper.It is the result of one order approximating after the exactitude formula has been expanded.The height relative error is presented owing to the truncation of Tailor series.According to the tolerance level of relative error,the applicability of formula is analyzed.The applicable bound is brought forth in figure at tolerance level 0.01 and 0.001.Both the teaching and radar engineering practice will benefit from this work.",
        "keywords": [
            "relative error",
            "Tailor exploration",
            "height measurement"
        ],
        "authors": [
            {
                "name": "XU Zhen-hai",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "RAO Bin",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Wei",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electrical & Electronic Education",
        "year": 2013
    },
    "lTNJvEJ6": {
        "id": "lTNJvEJ6",
        "title": "Coupling Scattering Characteristic Analysis of Dihedral Corner Reflectors in SAR Images.",
        "abstract": "The scattering mechanisms of dihedral corner reflectors have attracted great attention in the past decades. However, the scattering centers of dihedral corners are not discussed systematically. In this paper, the multi-bouncing scattering mechanism of dihedral corners is analyzed in detail based on the scattering characteristics of polygon plates and ray-tracing technique. Furthermore, the coupling scattering center (CSC) is proposed as a detailed explanation of the multi-bouncing scattering mechanism of dihedral corners and the locations of CSCs in the high-resolution range profile are deduced based on the monostatic-and-bistatic equivalence theorem. CSCs give a precise description of target structures and can improve the ability of radar target recognition. Finally, the simulation results via electromagnetic computation validate the theoretical analysis.",
        "keywords": "",
        "authors": [
            {
                "name": "Zhiming Xu",
                "org": ""
            },
            {
                "name": "Xiaofeng Ai",
                "org": ""
            },
            {
                "name": "Qihua Wu",
                "org": ""
            },
            {
                "name": "Feng Zhao",
                "org": ""
            },
            {
                "name": "Shunping Xiao",
                "org": ""
            }
        ],
        "venue": "IEEE Access",
        "year": 2018
    },
    "bPItVxSw": {
        "id": "bPItVxSw",
        "title": "Design and Realization of Universal Jamming Simulation System",
        "abstract": "The universal jamming signal simulation system is an indispensible part of radar simulation system.The relationships between jamming signal system and radar simulation system and each jamming mode's characteristics are analyzed.The method of design and realization jamming system is put forward and the realization model of key module is presented.The simulation result validates the availability of the design method and the legitimacy of system.The universal jamming mode signals can be produced in the jamming system.The code of program can be used in other system easily.",
        "keywords": [
            "universal jamming simulation system",
            "radar simulation system",
            "deception jamming",
            "blanketing jamming"
        ],
        "authors": [
            {
                "name": "HE Zhi-qiang",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China;PLA,No.61251 Troop,Hebei Qinhuangdao ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "LIU Jin",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "LIU Zhong",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            }
        ],
        "venue": "Modern Defence Technology",
        "year": 2012
    },
    "b8u8d30n": {
        "id": "b8u8d30n",
        "title": "An Equivalent Simulation Method for Pulse Radar Measurement in Anechoic Chamber.",
        "abstract": "When a pulse radar signal is implemented in a range-limited anechoic chamber for radar measurement, the transmitted and reflected signal will be coupled at the receiver. To solve this problem and equivalently simulate the whole process of pulse radar measurement in an anechoic chamber, the interrupted transmitting and receiving method is proposed in this letter based on interrupted sampling. The constraints of the transmitting and receiving parameters are deduced with the sizes of the anechoic chamber and target. The pulse compression of the proposed method is performed. Then, the window function is applied to extract the main peaks after pulse compression. Both the simulation and experimental results are provided to demonstrate the effectiveness of the proposed method in overcoming the coupling between the transmitted and reflected pulse signals.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Guoyu Wang",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Changsha, China"
            }
        ],
        "venue": "IEEE Geosci. Remote Sensing Lett.",
        "year": 2017
    },
    "q9znwNKc": {
        "id": "q9znwNKc",
        "title": "Sensitivity Analysis Method of Factors for Radar Based on Orthogonal Design",
        "abstract": "Analysis of the influence of radar for various factors sensitivities in complex war field environment plays an important role in the technology of radar countermeasures and effectiveness evaluation.A method for analyzing the radar sensitivity is proposed based on orthogonal experiment design.It is a method using variance analyzing for experiment data.The proposed method has the following characteristics: fewer simulating experiment data are needed;faster in quantificational analyzing of various factors sensitivities,and so on.This method overcomes the defects of traditional methods which have heavy computation complexity in the case of many parameters.In the end,an application example in the case of stand off jamming is given.The results of radar sensitivity analyzing identifies have verified the efficiency and validity of this method.",
        "keywords": [
            "stand-off jamming",
            "orthogonal design",
            "sensitivity analysis",
            "analysis of variance"
        ],
        "authors": [
            {
                "name": "MO Shuang-xi",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "ZHANG Wen-ming",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "LIU Jin",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "NUDT,School of Electronic Science and Engineering,Hunan Changsha ,China"
            }
        ],
        "venue": "Modern Defence Technology",
        "year": 2012
    },
    "Hb7nBApv": {
        "id": "Hb7nBApv",
        "title": "Modeling of Multiple Unresolved Targets Echo Characteristics for LFM Pulse Radar",
        "abstract": "Detection and discrimination of multiple unresolved targets is a frontier topic and pressing task in radar technology field,of which the analysis of multiple unresolved targets echo characteristics is the basis and precondition for solving other problems.Multiple targets echo magnitude and phase characteristics of linear frequency modulation(LFM) pulse radar were studied,multiple targets echo signal models were established and were compared with bistatic radar,simulation experiments based on different scenarios were presented.It is indicated by simulation results that,when multiple unresolved targets exist,multiple unresolved targets echoes synthesize coherently,target positions,magnitudes and phases will result in echo spectrum aberration;at the same time,when target ranges are different between each other,the main lob\u2019s phase of LFM pulse compression output changes tempestuously,other than single target case.",
        "keywords": [
            "modeling",
            "echo characteristics",
            "multiple unresolved targets",
            "LFM"
        ],
        "authors": [
            {
                "name": "MIN Tao",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xiang",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2013
    },
    "FwqQiJ6f": {
        "id": "FwqQiJ6f",
        "title": "Comparison of LFM and Step-Frequency High Resolution Range Technology",
        "abstract": "The principle of LFM and step-frequency HRR technology are investigated in this paper.The performance of the LFM and step-frequency are compared in the stationary target case and moving target case.It is derived that for the stationary target,the HRR profiles gained by LFM and step-frequency are equivalent.And for the moving target,the range profile shifting and spreading gained by step-frequency is much greater than LFM.",
        "keywords": [
            "high-resolution range profile",
            "step-frequency",
            "LFM"
        ],
        "authors": [
            {
                "name": "LAN Yun",
                "org": "Department of Opto-electronics Equipment,The Academy of Command & Technology,,Beijing ,China"
            },
            {
                "name": "LI Jin-liang",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Hunan Institute of Science and Technology(Natural Sciences)",
        "year": 2008
    },
    "7ogO2ZUb": {
        "id": "7ogO2ZUb",
        "title": "A micro-motion information reconstruction method based on compressed sensing for precession ballistic targets.",
        "abstract": "For a wideband radar system adopting stepped frequency signal (SFS), the micro-motion parameter is usually obtained by time-frequency analysis of the echo HRRPs (high resolution profiles). The data to be collected mainly includes each sub-frequency echo in the slow-time domain, which brings a great burden to the signal generation equipment and data storage on the radar system. Because of the sparseness of the ballistic target scatters in high frequency area, this paper adopts the compressed sensing technique to reduce the sampling data by randomly transmitting the stepped frequency signal. The performance of the proposed method is analyzed by the precession target measurement experiment in the anechoic chamber. The experimental results show that for the nose cone, middle circular ring and bottom circular ring of experimental missile target, when the sampling rate is no less than 50%, 30% and 30% respectively, the reconstruction result is qualified for micro-motion parameter extraction.",
        "keywords": "",
        "authors": [
            {
                "name": "Qihua Wu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Shunping Xiao",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, Hunan, P. R. China"
            }
        ],
        "venue": "EUSIPCO",
        "year": 2017
    },
    "T15vrnH0": {
        "id": "T15vrnH0",
        "title": "Advanced Coherent Video Modeling and Simulation Method of Phased Array Radar",
        "abstract": "The traditional coherent video modeling method of phased array radars is complicated,the calculate efficiency is quite low,all of these problems are resistance to the application of coherent video simulation.Aiming at this problem,an advanced coherent video modeling method and simulation model of phased array radars was investigated,and then phased array radar coherent video simulation system was proposed.The simulation result verifies that calculation efficiency of simulation system is highly improved.All the work above proves the efficiency of modeling method including mathematical modules,which supports wide application of phased array radar coherent video simulation.",
        "keywords": [
            "accelerate",
            "modeling",
            "radar",
            "coherent video simulation"
        ],
        "authors": [
            {
                "name": "WANG Xiang",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "MIN Tao",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YANG Jian-hua",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Guo-yu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2013
    },
    "uki2ARyN": {
        "id": "uki2ARyN",
        "title": "A Novel Method for Detecting Multiple Unresolved Targets Using Hybrid Multistatic Radar",
        "abstract": "Detection of multiple unresolved targets is a frontier topic and pressing task in radar technology field.A signal fusion method of a T/R-R2 hybrid multistatic radar system is presented,target echo signal models of a monostatic radar receiver and two multistatic radar receivers are established,considering three-dimensional space situation,the signal fusion model is presented based on range information and the multiple unresolved targets are detected with maximum likelihood method,and the effects of SNR,number of targets,target fluctuation,detection threshold and hybrid multistatic radar geometrical configuration on the detection performance are analyzed.The Monte Carlo simulation results identify the effectiveness of the method.The detection method is presented under the assumed condition of Swerling II targets,but it is still suitable for Swerling 0 and IV targets.",
        "keywords": [
            "Multiple unresolved targets detection",
            "Range information",
            "Hybrid multistatic radar"
        ],
        "authors": [
            {
                "name": "Min Tao",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhao Feng",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Xiao Shun-ping",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2012
    },
    "1ws4jfbT": {
        "id": "1ws4jfbT",
        "title": "Time Management of Radar EW Distributed Simulation System",
        "abstract": "The main object of this paper is to present a simulation method of transferring the radar electronic warfare(EW) simulation from single system to distributed platform based on High Level Architecture(HLA),by analyzing and realizing the HLA time management application in radar EW simulation system,which is the core interface of HLA.The main method used is to present the realization of such interface content as time management strategy,time advance mechanism and so on combined with characteristics of various radar EW simulation objects,especially the phased array radar beam schedule flow.The simulation time advancement result is then given combined with one air defense weapon system,from which the conclusion is obtained that the running efficiency of radar EW distributed simulation system based on HLA is superior to that of the system based on single system.",
        "keywords": [
            "Distributed simulation",
            "Time management",
            "Radar EW",
            "HLA"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha Hunan ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha Hunan ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha Hunan ,China"
            }
        ],
        "venue": "Computer Simulation",
        "year": 2007
    },
    "ftgZWx84": {
        "id": "ftgZWx84",
        "title": "Models and Realization of Target Recognition Simulation System in Ballistic Midcourse",
        "abstract": "As the main sensor in ballistic midcourse,radar plays an important role in the target recognition. According to the requirement of the ballistic target recognition simulation system and the character of the ballistic target recognition,the key models,such as generation of dynamic target characteristic data,feature extraction and fusion recognition,were proposed. The ballistic target recognition simulation system was designed and realized. The analysis was done according to the typical simulation scene. Results show that the system is reliable and can support the research of target recognition in Ballistic Midcourse.",
        "keywords": [
            "model",
            "ballistic midcourse",
            "radar",
            "target recognition",
            "simulation"
        ],
        "authors": [
            {
                "name": "LIU Jin",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "FENG De-jun",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Guo-yu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2008
    },
    "pcDGVAkq": {
        "id": "pcDGVAkq",
        "title": "Detection of Presence of Multiple Unresolved Targets Based on Range Glint",
        "abstract": "In ballistic missile defense,the situation of unresolved targets is of great threaten to the tracking,identification and guidance of ground based radars,and some special efforts must be adopted to deal with it,among which the detection of the presence of unresolved targets is the precondition and basis of all the others.In this paper,the range glint is analyzed in theory through the model of sample ratio established,and then its physical essence is also expatiated using echo spectrum aberration.Base on those above,a general likelihood ratio test is developed to detect the presence of unresolved targets,which uses the information of additional range measurement error introduced by range glint.Finally,the Monte Carlo simulation result identifies the validity of the models.",
        "keywords": [
            "range glint",
            "adjacent range cell samples",
            "sample ratio",
            "general likelihood ratio",
            "unresolved targets"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan ,China"
            },
            {
                "name": "YANG Jian-Hua",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan ,China"
            },
            {
                "name": "DAN Mei",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan ,China"
            },
            {
                "name": "LIU Jia-qi",
                "org": "The National Key Laboratory of Computational Mathematics and Experimental Physics,Beijing ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan ,China"
            }
        ],
        "venue": "Acta Electronica Sinica",
        "year": 2008
    },
    "FKsP9XLk": {
        "id": "FKsP9XLk",
        "title": "Optimal Search Order of Tracking and Guiding Radars in Ballistic Missile Defense Based on Search Data Rate",
        "abstract": "Searching in the small window airspace based on cuing information is a very important search mode for tracking and guiding radars in ballistic missile defense,and the high speed of the ballistic missile has brought a great challenge to the radar's search order of beams in this method.In this paper,a method to determine the optimal search order based on search data rate is brought forward.First,according to the rule of cumulative detection probability maximization,the static optimal data rate model of search beams is established.Using the calculation result of the model,the static search order of beams is achieved.And then,based on those above,the dynamic search order of beams is achieved through the way of making the illuminating beam match the movement of the target.Finally,the simulation results are given,which validate the validity of the method presented under the condition of high speed targets.",
        "keywords": [
            "tracking and guiding radar",
            "search data rate",
            "ballistic missile defense",
            "dynamic matching",
            "optimal search order"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan  Chian"
            },
            {
                "name": "BI Li",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan  Chian"
            },
            {
                "name": "ZHOU Ying",
                "org": "Postbox 061,Luoyang Henan  Chian"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan  Chian"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha,Hunan  Chian"
            }
        ],
        "venue": "Acta Electronica Sinica",
        "year": 2009
    },
    "ZoBPBGkX": {
        "id": "ZoBPBGkX",
        "title": "Precession and Structural Parameter Estimation of the Cone-shaped Warhead Based on the Micro-Doppler",
        "abstract": "Micro-motion feature is one of the effective features used for radar target recognition in the middle section of the ballistic curve.The micro-Doppler expressions of the scattering center at the conical point and two sliding scattering centers in the conical bottom are derived,firstly.The micro-Doppler of the scattering center at the conical point calculated by its micro-Doppler expression is little different to that which is getting by the Geometrical Theory of Diffraction(GTD).The other two scattering center's micro-Doppler achieved by the two methods coincide with each other.Three correlations of the micro-Doppler of the three scattering centers are founded by analyzing their micro-Doppler expressions.Then a method of precession and structural parameter estimation is proposed by using the magnitudes of the micro-Doppler at some times,which can obtain from the time-frequency analysis.Using the method to extract six precession and structural parameters in different angles of incidence is analyzed,and the simulated results validate the effectiveness of the proposed method.",
        "keywords": [
            "Sliding scattering center",
            "Radar target recognition",
            "Geometrical Theory of Diffraction(GTD)",
            "Parameter estimation",
            "Micro-Doppler"
        ],
        "authors": [
            {
                "name": "Zou Xiao-hai",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Ai Xiao-feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Li Yong-zhen",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhao Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Xiao Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2011
    },
    "UdKpspLQ": {
        "id": "UdKpspLQ",
        "title": "Improved Active Echo Cancellation Against Synthetic Aperture Radar Based on Nonperiodic Interrupted Sampling Modulation",
        "abstract": "Echo cancellation is an ingenious method that protects the target of interest (TOI) by cancelling target echo at radar receiver with an active source. Recently the cancellation method using frequency and time-delay modulation has been proposed, considering the unavoidable processing time for the canceler when synthetic aperture radar (SAR) transmits large time bandwidth product signals such as linear frequency modulation pulses. Then the cancellation signal can cancel out the target echo even when it lags behind. However, echo cancellation also requires precise amplitude match of cancellation signal and target echo at SAR receiver. Amplitude match relies on accurate transmitting power calculation, which is difficult to guarantee considering prior information errors. In the presence of amplitude mismatch, the target echo cannot be completely cancelled thus remains visible in the SAR image. In this paper, we proposed an improved echo cancellation method based on nonperiodic interrupted sampling modulation, which produces high-level side lobes performing as a continuous jamming strip along range direction after matched filtering processing. By applying the proposed method, the residual of TOI in SAR image is covered by the jamming strip, thus a more robust echo cancellation is obtained in the presence of amplitude mismatch. Measured SAR data simulations demonstrate the effectiveness of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Qihua Wu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Junjie Wang",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Shunping Xiao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            }
        ],
        "venue": "IEEE Sensors Journal",
        "year": 2018
    },
    "BKHFWEEL": {
        "id": "BKHFWEEL",
        "title": "Micro-Doppler of non-ideal scattering centers",
        "abstract": "Non-ideal scattering centers exist commonly on radar targets. The scattering characteristics of them induce additional modulation or components to the micro-Doppler. Two typical kinds of non-ideal scattering centers are analyzed and micro-Doppler model of the scattering centers on the ring structure of precession targets are introduced as a detailed example. The experimental results demonstrate the model.",
        "keywords": [
            "electromagnetic wave scattering",
            "military radar",
            "modulation",
            "radar target recognition",
            "microDoppler model",
            "modulation",
            "nonideal scattering centers",
            "precession targets",
            "radar targets",
            "ring structure",
            "scattering characteristics",
            "Micro-Doppler",
            "Micro-motion",
            "Non-ideal scattering centers"
        ],
        "authors": [
            {
                "name": "Liu Jin",
                "org": "State Key Lab. of Complex Electromagn. Environ. Effects on Electron. & Inf. Syst., Changsha, China|c|"
            },
            {
                "name": "Zhao Feng",
                "org": ""
            },
            {
                "name": "Zhang Yanqing",
                "org": ""
            },
            {
                "name": "Ai Xiaofeng",
                "org": ""
            }
        ],
        "venue": "Xi'an",
        "year": 2013
    },
    "8vy3NOPv": {
        "id": "8vy3NOPv",
        "title": "Quantitative evaluation for self-screening jamming effectiveness based on the changing characteristics of intercepted radar signals",
        "abstract": "In the process of adaptive radar countermeasure, it is critical to evaluate the jamming effectiveness. Most of conventional methods rely on the data collected on radar side, which is unavailable under battlefield background. An approach for evaluating the effectiveness of self-screening jamming quantitatively from the view of reconnaissance and jamming systems is proposed. Since the amplitude and data rate of intercepted radar pulses before and after jamming vary obviously, the accumulated amplitude extracted from signals is chosen as the characteristic statistic. According to the response mechanism of jammed radar, the effectiveness evaluation detector is designed based on the theory of significance test. Under the condition of typical scenario in which ship-borne air-defense radar operates, simulations are performed to evaluate jamming effectiveness utilizing the proposed method. Simulations suggest that the results of evaluation appear completely consistent with the message displayed on radar side, which attests the validity of the approach.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Ou",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, Changsha, Hunan, China"
            },
            {
                "name": "Feng Zhao",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, Changsha, Hunan, China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, Changsha, Hunan, China"
            },
            {
                "name": "Jin Liu",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, Changsha, Hunan, China"
            },
            {
                "name": "Shunping Xiao",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, Changsha, Hunan, China"
            }
        ],
        "venue": "ieee international radar conference",
        "year": 2016
    },
    "JSYb3o6s": {
        "id": "JSYb3o6s",
        "title": "Missile Defense Radar Simulation System",
        "abstract": "This paper presents a distributed,modularized and expandable missile defense radar functional simulation system analyzing and modeling its main mathematical modules,based on characteristics of ground-based phased array radars in missile defense system and principle of High Level Architecture(HLA).Simulation is carried out whose result verifies the efficiency.The successful exploitation of the system will supply the analyses and evaluation of the whole missile defense system efficiency with performance and basis.",
        "keywords": [
            "simulation system",
            "distributed",
            "missile defense radar",
            "High Level Architecture"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LI Dun",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2006
    },
    "xdsxEWw5": {
        "id": "xdsxEWw5",
        "title": "Sensitivity Analysis of Practical Factors for Radar Based on Simulation System",
        "abstract": "Analyzing radar's sensitivity to various factors in complex war field environment plays an important role in radar countermeasures and effectiveness evaluation.However,a lot of inconveniences will be encountered by using real equipment to make sensitivity analysis.A radar simulation system is built for this analysis by Monte Carlo experiments.As a result,the sensitivity analysis of stand-off jamming,ground clutter and chaff with maneuvering targets for radar is completed with many data and conclusions.In the end,an application example in the case of stand-off jamming is given.The results show that the radar sensitivity analyzing based on simulation system is convenient and effective.",
        "keywords": [
            "stand-off jamming",
            "simulation system",
            "phased array radar",
            "sensitivity analysis",
            "single variance analysis"
        ],
        "authors": [
            {
                "name": "YAN Cong-zhi",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "LIU Jin",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "WANG Lian-dong",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            }
        ],
        "venue": "Modern Defence Technology",
        "year": 2013
    },
    "LyXGFxrR": {
        "id": "LyXGFxrR",
        "title": "Communication Connectivity Modeling for System-of-systems Combat Simulation System",
        "abstract": "Aiming at the practical requirements for the communication connectivity function in the system-of-systems combat simulation system based on weapon platforms,the construction,function and simulation flow of the communication connectivity module were proposed,and critical models were analyzed,and especially the path loss computation and FOV determining models were described emphatically.Simulation result verifies the efficiency.The successful exploitation of the communication connectivity module will supply the implementation of system-of-systems combat simulation system the basis,and will supply the analysis,research,development,evaluation,modeling and simulation of the electronic information systems and equipments with reference.",
        "keywords": [
            "path loss",
            "system-of-systems combat simulation",
            "field of view(FOV)",
            "communication connectivity"
        ],
        "authors": [
            {
                "name": "MIN Tao",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YANG Jian-hua",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LI Dun",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2013
    },
    "DcFd28AG": {
        "id": "DcFd28AG",
        "title": "Feature Extraction of Precession and Structure of Cone-shaped Object Based on Time-HRRP Distribution",
        "abstract": "Utilizing multi-feature for ballistic target recognition is a trend in the ballistic missile defense field.In the published literatures,the structure feature extraction of ballistic targets need know some precession parameters,while the precession feature extraction need know some structure parameters,which makes a deadlock in the feature extraction of ballistic targets.Firstly,this paper analyzes the trace of each scatter in the time-High Range Resolution Profile(HRRP) distribution of the cone-shaped warhead in detail.Then,based on the time-HRRP distribution and combining the trace and geometry relation of each scatter,the precession feature,including the precession frequency,precession angle,initial phase angle and the angle between the precession axis and the Line Of Sight(LOS),and the structure feature,including the target height,radius of the undersurface,distance between the centroid and undersurface,and the distance between the centroid and radar,are extracted jointly.Finally,the simulation results are given for validating the proposed algorithms.",
        "keywords": [
            "Cone-shaped warhead",
            "Generalized Hough Transform(GHT)",
            "High Range Resolution Profile(HRRP)",
            "Feature extraction",
            "Micro-motion"
        ],
        "authors": [
            {
                "name": "Ai Xiao-feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zou Xiao-hai",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Li Yong-zhen",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhao Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Xiao Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2011
    },
    "zsm27eMW": {
        "id": "zsm27eMW",
        "title": "Function Simulation Method of Angle Deception Based on Signal Simulation Support",
        "abstract": "For overcoming shortcomings of function simulation and signal simulation,a new function simulation method of angle deception is proposed based on signal simulation support.After two radar system simulation methods being introduced,the new method principal idea of angle deception is expounded.Take the cross-polarization angle deception as a example,those key models of angle deception are put forward and the actualization steps are illuminated in detail.Lastly,the difference of consumed time and simulation precision of two methods are analyzed.The validity and feasibility of the new method are verified by simulation test.",
        "keywords": [
            "signal simulation",
            "function simulation",
            "angle deception",
            "monopulse radar"
        ],
        "authors": [
            {
                "name": "YANG Jian-hua",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "FENG De-jun",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "National University of Defense Technology,School of Electronic Science and Engineering,Hunan Changsha ,China"
            }
        ],
        "venue": "Modern Defence Technology",
        "year": 2012
    },
    "tDCXhOQK": {
        "id": "tDCXhOQK",
        "title": "Considerations on Improving the Quality of Graduation Project of Undergraduats",
        "abstract": "Graduate project is an important and integrative part of undergraduate education.In this paper,the current problems existing in graduate project of military universities are analyzed,as well as the reasons.Based on those above,suggestions on improving the quality of graduate project are put forward,among which different directing methods for students of engineering technology and integrated training according to their own characteristics are emphasized.Finally,the graduate project practicing production in our laboratory validates the methods.",
        "keywords": [
            "engineering technology",
            "graduation project",
            "integrated training"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "chool of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LIU Jin",
                "org": "chool of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "BI Li",
                "org": "chool of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Wei",
                "org": "chool of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electrical & Electronic Education",
        "year": 2011
    },
    "WYI4jFhx": {
        "id": "WYI4jFhx",
        "title": "Extended target detection of MIMO radar based on GLRT in compound-Gaussian clutter",
        "abstract": "Multiple-input multiple-output (MIMO) radars with wideband signals are useful to discriminate target in clutter. With wideband MIMO radar, the problem of extended target detection in compound-Gaussian clutter is considered in this paper. By obtaining target echoes from each antenna, the detector based on generalized likelihood ratio test (GLRT) is developed. It shows that the shape parameter of clutter, Doppler mismatches and antenna configurations of MIMO radar heavily affect the performance of GLRT detector. Therefore, the detection performance is respectively analysed with different shape parameters and Doppler mismatches. By using maximum likelihood estimation (MLE), the detection curves with typical parameters are presented to illustrate that the proposed detector outperforms that obtained in Gaussian clutter. Then, the detection performance is discussed with different antenna configurations. Mathematical analysis and simulation results show that the detection performance reaches the best when the numbers of transmitters and receivers are equal, which provides reference for the antenna configuration of MIMO radar.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, No. 109 Deya Street, Changsha, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, No. 109 Deya Street, Changsha, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, No. 109 Deya Street, Changsha, China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, No. 109 Deya Street, Changsha, China"
            },
            {
                "name": "Guoyu Wang",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, No. 109 Deya Street, Changsha, China"
            }
        ],
        "venue": "international radar symposium",
        "year": 2017
    },
    "5wmTTm1B": {
        "id": "5wmTTm1B",
        "title": "A Radar Imaging Method Using Nonperiodic Interrupted Sampling Linear Frequency Modulation Signal",
        "abstract": "Linear frequency modulation (LFM) signal is widely applied in imaging radar including synthetic aperture radar (SAR) and inverse SAR (ISAR). Jamming techniques against LFM imaging radar develop rapidly in the past decades, which make radar imaging with LFM signal to face a great challenge. In this paper, a novel radar imaging method using nonperiodic interrupted sampling-LFM (NIS-LFM) signal is proposed. The radar anti-jamming performance can greatly benefit due to the random property of the NIS-LFM signal. Besides, the compressive sensing-based algorithm is further proposed for radar image reconstruction by utilizing the piecewise sparsity of the NIS-LFM echo. Both measured ISAR data simulations and microwave anechoic chamber experiments demonstrate the validity of the proposed imaging method.",
        "keywords": "",
        "authors": [
            {
                "name": "Qihua Wu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Shunping Xiao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            }
        ],
        "venue": "IEEE Sensors Journal",
        "year": 2018
    },
    "jqb9FWy3": {
        "id": "jqb9FWy3",
        "title": "Research of Testing Method for Component-Based Radar Simulation System",
        "abstract": "The component-based design has great advantages in the development of radar simulation system such as reusable and easily extensible,but yet new challenges have been brought in software testing.To make the testing for component-based radar simulation system more efficiency,and to accelerate the application of component-based technique in radar simulation,the component testing technology in existence was analyzed,and combined with the domain characteristic in radar simulation,a layered component testing method based on the metadata was suggested.The basic characteristic of radar component metadata and the description method based on XML were analyzed in detail,the testing architecture was developed,and the research on the automatic testing for radar component was accomplished.Finally,the testing method was validated by an example of automatic radar component testing.",
        "keywords": [
            "simulation component",
            "radar",
            "metadata",
            "automatic testing"
        ],
        "authors": [
            {
                "name": "GUO Jin-liang",
                "org": "1.Unit 63880 of PLA,Luoyang ,China,"
            },
            {
                "name": "LIU Jin",
                "org": "2.School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "HAN Wen-bin",
                "org": "1.Unit 63880 of PLA,Luoyang ,China,"
            },
            {
                "name": "WANG Hua-bing",
                "org": "1.Unit 63880 of PLA,Luoyang ,China,"
            },
            {
                "name": "ZHAO Feng",
                "org": "2.School of Electronic Science and Engineering,NUDT,Changsha ,China"
            }
        ],
        "venue": "Fire Control & Command Control",
        "year": 2012
    },
    "jZAB3NGC": {
        "id": "jZAB3NGC",
        "title": "Performance analysis of pulse radar target probing based on non-ideal interrupted transmitting and receiving in RFS",
        "abstract": "When pulse radar signal is applied in a range limited anechoic chamber for target probing, the transmitted and reflected signal are coupled at the receiver. Interrupted transmitting and receiving (ITR) method can be used to solve this problem. However, the ideal rectangle ITR control signal is difficult to be generated by radio frequency simulation (RFS) system and the period of ITR is unstable in the RFS system. To model the ITR control signal precisely, the trapezoidal pulse is considered to analyze the property of target echo. Besides, the simulations and anechoic chamber experiments are conducted when the ITR period jitters. It shows that the range compression obtained by non-ideal ITR control signal is almost identical with that obtained by the ideal ITR control signal after compensation, which indicates that the ITR method is effective and practical in engineering.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Deya Street No. 109, Changsha, P. R. China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Deya Street No. 109, Changsha, P. R. China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Deya Street No. 109, Changsha, P. R. China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Deya Street No. 109, Changsha, P. R. China"
            },
            {
                "name": "Guoyu Wang",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics & Information System, National University of Defense Technology, Deya Street No. 109, Changsha, P. R. China"
            }
        ],
        "venue": "international conference on signal processing",
        "year": 2017
    },
    "iKypKGF7": {
        "id": "iKypKGF7",
        "title": "Novel Approach for the Recognition and Prediction of Multi-Function Radar Behaviours Based on Predictive State Representations.",
        "abstract": "The extensive applications of multi-function radars (MFRs) have presented a great challenge to the technologies of radar countermeasures (RCMs) and electronic intelligence (ELINT). The recently proposed cognitive electronic warfare (CEW) provides a good solution, whose crux is to perceive present and future MFR behaviours, including the operating modes, waveform parameters, scheduling schemes, etc. Due to the variety and complexity of MFR waveforms, the existing approaches have the drawbacks of inefficiency and weak practicability in prediction. A novel method for MFR behaviour recognition and prediction is proposed based on predictive state representation (PSR). With the proposed approach, operating modes of MFR are recognized by accumulating the predictive states, instead of using fixed transition probabilities that are unavailable in the battlefield. It helps to reduce the dependence of MFR on prior information. And MFR signals can be quickly predicted by iteratively using the predicted observation, avoiding the very large computation brought by the uncertainty of future observations. Simulations with a hypothetical MFR signal sequence in a typical scenario are presented, showing that the proposed methods perform well and efficiently, which attests to their validity.",
        "keywords": [
            "multi-function radar",
            "operating mode recognition",
            "predictive state representation",
            "signal prediction"
        ],
        "authors": [
            {
                "name": "Jian Ou",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, Changsha 410073, China. jianou@nudt.edu.cn."
            },
            {
                "name": "Yongguang Chen",
                "org": "Beijing Institute of Tracking & Telecommunications Technology, Beijing 100094, China. ygchen@netease.com."
            },
            {
                "name": "Feng Zhao",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, Changsha 410073, China. zhfbee@tom.com."
            },
            {
                "name": "Jin Liu",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, Changsha 410073, China. liujin@nudt.edu.cn."
            },
            {
                "name": "Shunping Xiao",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, Changsha 410073, China. qwertmingx@tom.com."
            }
        ],
        "venue": "Sensors",
        "year": 2017
    },
    "dizsAidw": {
        "id": "dizsAidw",
        "title": "Method for operating mode identification of multi-function radars based on predictive state representations",
        "abstract": "Operating mode identification of multi-function radars (MFRs) is critical in radar threat evaluation and electronic jamming decisions. The hidden Markov model (HMM) in conventional methods relies on the MFR prior knowledge and cannot accurately describe the MFR signal sequence with regularity. An identifying method is presented that is based on predictive state representation (PSR) models without the help of prior information, which is unlikely to be obtained. Simulations of synthetic MFR signals are used to demonstrate the applicability of the novel method and to summarise the training parameter setting principles, which are of practical significance in applications of the method. The PSR-based method is shown to be more effective than the HMM-based methods, in particular when applied to the radar signal sequence with unknown regularity. The method also contains a novel approach to reducing the dimension of the system-dynamics matrix, which enables the algorithm to perform well in conditions of heavy noise. Simulation results attest to the validity of the proposed method. With the proposed method, the operating modes of radars can be identified accurately, which is significant in supporting adaptive countermeasures against MFRs.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Ou",
                "org": "National University of Defence Technology, People's Republic of China"
            },
            {
                "name": "Yongguang Chen",
                "org": "Beijing Institute of Tracking & Telecommunications Technology, People's Republic of China"
            },
            {
                "name": "Feng Zhao",
                "org": "National University of Defence Technology, People's Republic of China"
            },
            {
                "name": "Jin Liu",
                "org": "National University of Defence Technology, People's Republic of China"
            },
            {
                "name": "Shunping Xiao",
                "org": "National University of Defence Technology, People's Republic of China"
            }
        ],
        "venue": "IET Radar, Sonar & Navigation",
        "year": 2017
    },
    "xkOKXvxZ": {
        "id": "xkOKXvxZ",
        "title": "Analysis on Trajectory Prediction Error of Warning System in Ballistic Missile Defense",
        "abstract": "Based on the auxiliary coordinate system established,the process of the trajectory prediction in ballistic missile midcourse defense warning system was decomposed through a series of coordinate transforming,which simplifies the expression form and calculation process of the predicted states.The trajectory prediction error in sine coordinate of the tracking radar was analyzed,and its calculation method in engineering was also given.The Monte Carlo simulation result was given.Analysis and simulation result shows that the prediction error achieved by this method is equivalent to the actual result,and its calculation process is simpler and more efficient than the traditional method.",
        "keywords": [
            "Ballistic missile defense",
            "Error analysis",
            "Trajectory prediction",
            "Warning system"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "BI Li",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "Shunping Xiao",
                "org": "National University of Defense Technology(National University of Defense Technology,National Univ. of Defense Technology),Changsha,China"
            }
        ],
        "venue": "Journal of Ballistics",
        "year": 2008
    },
    "v9sUAaG6": {
        "id": "v9sUAaG6",
        "title": "Bistatic Micro-Doppler of the Spinning Warhead with Fins",
        "abstract": "Micro-motion feature is one of the effective features used for radar target recognition in the middle section of the ballistic curve.To solve the problem of estimating spinning and structural parameters based on the micro-Doppler of the spinning warhead with fins in bistatic radar,the micro-Doppler models of the scattering centers at the edge of fins and the conjunction of the fins and the body of warhead are derived when the warhead is spinning firstly.Then the bistatic scattering coefficients of the warhead model are calculated by using FEKO.The micro-Doppler models are verified from the time frequency analysis on the bistatic scattering coefficients,and the characteristics of the micro-Doppler are summarized.Thirdly,the feasibility of extracting spinning and structural parameters in bistatic radar is analysed.Finally,because Hough transform can not estimate the parameters because of the flashes,a new idea to extract the parameters using the flashes is proposed.",
        "keywords": [
            "Bistatic radar",
            "Warhead with fins",
            "Time frequency analysis",
            "Micro-Doppler",
            "Scattering center"
        ],
        "authors": [
            {
                "name": "Zou Xiao-hai",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Ai Xiao-feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Li Yong-zhen",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhao Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Xiao Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2012
    },
    "BaAListf": {
        "id": "BaAListf",
        "title": "The Reflection and Practice of Directing the Graduation Project of Joint-Training Undergraduates",
        "abstract": "Graduation project of joint-training undergraduates is the important bridge connecting the study in technical college and that in military academy and their future commanding post in the army.In order to improve the quality of the joint-training undergraduates,National University of Defense Technology reforms the directing mode of the graduation project,transferring from academic research to problem solving of the army.This paper analyses the characteristic of the graduation project,proposes our thinking on all the stages: dissertation arrangement,sub-task design,directing methods and result form.We put into practice our ideas in directing joint-training undergraduates in the communication major and analyses the effect.",
        "keywords": [
            "graduation project",
            "Joint-Training undergraduates",
            "cadets"
        ],
        "authors": [
            {
                "name": "LIU Jin",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "College of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Higher Education Research",
        "year": 2012
    },
    "ToUBTjyQ": {
        "id": "ToUBTjyQ",
        "title": "ABN: Attribute based networking for enterprise networks",
        "abstract": "IP (Internet Protocol) has been tremendously successful over the past decades. Now the networking goal of 4A (Anywhere, Anytime, Anyone, Anything) is becoming a reality. However, there is still a long way to achieve the desired goal of 6R, which is to deliver the right information at the right time, in the right place, in the right way, from the right sender to the right receiver. Towards this goal, we first address the concept of attribute based networking, in which network decisions and controls are based on the attributes of the involved network entities. Then we propose a reference model for attribute based networking, called MAN. Network manageability, controllability, Security, QoS (Quality of Service), mobility, multi-homing, flexibility and evolvability can be achieved under the proposed MAN. Furthermore, by following MAN, we suggest a backward compatible architecture for enterprise networks, called ABA4, which can help to tackle a series of problems that current IP networks are facing, such as security, QoS, and mobility.",
        "keywords": "",
        "authors": [
            {
                "name": "Feng Zhao",
                "org": "College of Computer, National University of Defense Technology, Changsha, P.R. China"
            },
            {
                "name": "Baokang Zhao",
                "org": "College of Computer, National University of Defense Technology, Changsha, P.R. China"
            },
            {
                "name": "Yulei Yuan",
                "org": "College of Computer, National University of Defense Technology, Changsha, P.R. China"
            }
        ],
        "venue": "international conference on communication technology",
        "year": 2017
    },
    "mjOXrcfL": {
        "id": "mjOXrcfL",
        "title": "Experimental study on pulse radar target probing in RFS based on interrupted transmitting and receiving",
        "abstract": "Abstract   Radar target probing and measurement are challenging tasks for Radio Frequency Simulation (RFS) with pulse radar signal. Due to the long-time duration of pulse radar signal and the limited space of anechoic chamber, the reflected signal returns before pulse radar signal is fully transmitted in RFS. As a consequence, the transmitted and reflected signals are coupled at the receiver. To handle this problem, the Interrupted Transmitting and Receiving (ITR) experiment system is constructed in this paper by dividing the pulse radar signal into sub-pulses. The target echo can be obtained by transmitting and receiving the sub-pulses intermittently. Furthermore, the principles of ITR are discussed and the target probing experiments are performed with the ITR system. It is demonstrated that the ITR system can overcome the coupling between the reflected and transmitted signals. Based on the target probing results, the performance of pulse radar target probing and measurement can be verified in RFS with the ITR system.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha 410073, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha 410073, China"
            },
            {
                "name": "Qihua Wu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha 410073, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha 410073, China"
            },
            {
                "name": "Guoyu Wang",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha 410073, China"
            }
        ],
        "venue": "Chinese Journal of Aeronautics",
        "year": 2018
    },
    "4wUj3YCz": {
        "id": "4wUj3YCz",
        "title": "Study on Dense Barrage Jamming Based on Equivalent Reckoning of Radar ECM Test",
        "abstract": "In view of the requirement for radar ECM research and the difficulty in getting target radar,the substitutable equivalent reckoning theory used for dense barrage jamming is studied,then mathematical substitutable equivalent reckoning models and simulation model of target radar are established,and also a simulation system of target radar is presented.Based on radar ECM test data,the mathematical substitutable equivalent reckoning model and target radar simulation model are verified,and this provides an efficient and reliable analysis tool for researching into the effect of dense barrage jamming on target radar.",
        "keywords": [
            "Barrage jamming",
            "Model validation",
            "Simulation",
            "Modeling",
            "Equivalent reckoning"
        ],
        "authors": [
            {
                "name": "WANG Xiang",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "YANG Jian-hua",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "MIN Tao",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Guo-yu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Astronautics",
        "year": 2012
    },
    "ng6fzGSj": {
        "id": "ng6fzGSj",
        "title": "Research and Realization of Shipborne Phased Array Radar Simulation System",
        "abstract": "The design of software system is very important to the simulation of complex system such as shipborne phased array radar. To make the research of shipborne phased array radar simulation more efficiency, the idea of layered design was imported based on modularization, a hierarchy modularized and easy expansible simulation software architecture was established, and the whole simulation flow was suggested, the function and the theory and the realization flow of the core model was mainly researched, and the simulation software system was developed. The result of the simulation has validated the model and the method.",
        "keywords": [
            "phased array",
            "modularization",
            "simulation",
            "shipborne radar"
        ],
        "authors": [
            {
                "name": "GUO Jin-liang",
                "org": " School of Electronic Science and Engineering, National University of Defense Technology, Changsha , China; Unit 63880 PLA, Luoyang , China"
            },
            {
                "name": "ZHANG Yu",
                "org": " Naval Academy of Armament, Beijing , China"
            },
            {
                "name": "WANG Lian-dong",
                "org": " Unit 63880 PLA, Luoyang , China"
            },
            {
                "name": "ZHAO Feng",
                "org": " School of Electronic Science and Engineering, National University of Defense Technology, Changsha , China"
            },
            {
                "name": "LIU Jin",
                "org": " School of Electronic Science and Engineering, National University of Defense Technology, Changsha , China"
            }
        ],
        "venue": "Journal of System Simulation",
        "year": 2010
    },
    "hbnrJWAm": {
        "id": "hbnrJWAm",
        "title": "Distributed simulation of the phased array radar system",
        "abstract": "Phased array radar modeling and simulation based on advanced distributed platform is a certain trend in radar simulation nowadays.Based on the analysis of coherent video simulation and High Level Architecture(HLA) time management of the phased array radar system,a simulation method for phased array radar system in the distributed simulation based on HLA/RTI is presented.The time advancing of the radar system is improved.At last,the simulation running time before and after the improvement are given,which proves that the method can effectively improve the efficiency of the system.",
        "keywords": [
            "time management",
            "HLA",
            "distributed simulation"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Systems Engineering and Electronics",
        "year": 2006
    },
    "WAJoBvRh": {
        "id": "WAJoBvRh",
        "title": "Design and Implementation of Control Plan of New IPv6 Router",
        "abstract": "Based on ForCES(forwarding and control element separating) theory,the router can be separated into control layer and forwarding layer.This kind of design may bring forward great benefits,such as lower development cost,more scalable and reliable system.This paper introduces a kind of ForCES-based IPv6 router,gives the design and implementation of the control plan software modules,including route module,kernel protocol module,OpenRouter Master module and OpenRouter Agent module.",
        "keywords": [
            "control and forward separating",
            "architecture",
            "IPv6 router"
        ],
        "authors": [
            {
                "name": "CHEN Xiao-mei",
                "org": "School of Computer Science,National University of Defense Technology,Changsha "
            },
            {
                "name": "WANG Bao-sheng",
                "org": "School of Computer Science,National University of Defense Technology,Changsha "
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Computer Science,National University of Defense Technology,Changsha "
            },
            {
                "name": "TU Rui",
                "org": "School of Computer Science,National University of Defense Technology,Changsha "
            }
        ],
        "venue": "Computer Engineering",
        "year": 2007
    },
    "61K9B07n": {
        "id": "61K9B07n",
        "title": "Joint Radar Transmitter and Receiver Polarization Optimization Method Based on Optimal Detection",
        "abstract": "In this paper,a new joint radar transmitter and receiver polarization optimization method is proposed based on the optimal detection criterion.First,a fully-polarimetric radar echo model is introduced,and the fully-polarimetric target detection algorithm is designed based on Neyman Pearson criterion,the detection performance is derived and analyzed.Then,a joint radar transmitter and receiver polarization optimization method is proposed to improve the capability of the target detection.Finally,the simulation results demonstrate that the target detection performance can be improved by using this algorithm remarkably.",
        "keywords": [
            "Fully-polarimetric radar",
            "Optimization design",
            "Polarimetric detection"
        ],
        "authors": [
            {
                "name": "SUN Bin",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LI Yong-zhen",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Guo-yu",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Astronautics",
        "year": 2012
    },
    "sinfzN1c": {
        "id": "sinfzN1c",
        "title": "Full-polarization bistatic scattering characteristics analysis of stealth aircraft",
        "abstract": "Bistatic radar is a hot research topic in recent years, especially about passive bistatic radar and bistatic SAR, however, the polarimetric bistatic scattering characteristics of the target is not researched enough, which limits the detection and recognition capability of the bistatic radar. The whole spatial polarimetric bistatic scattering data of the full-size stealth aircraft model are calculated with the multi-level fast multipole algorithm (MLFMA) via the electromagnetic calculation software. The fluctuation characteristic statistic of the polarimetric bistatic radar cross section (RCS) is carried out, and it is found that the statistical properties of the four kinds of polarimetric bistatic RCS are nearly the same, while the monostatic main and cross polarization RCS statistical properties are quite different from each other as shown in Fig. 1. It is also found that dynamic ranges of the four polarimetric types of bistatic RCS is larger than the monostatic case and the mean values of the four polarimetric types of bistatic RCS are larger than the monostatic case. The distribution characteristics statistic of the monostatic and bistatic polarization ratio is carried out and it is found that the monostatic and bistatic cross-main polarization ratios are quite different, while the main polarization ratios are similar. So any type of polarization is suitable for the bistatic radar while only the main polarization for monostatic radar. What is more, the full polarimetric capability is strongly recommended for bistatic radar. All the statistic results also provide a theory reference for fully polarimetric bistatic radar stealth aircraft target detection experiments.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, China"
            },
            {
                "name": "Jianhua Yang",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, China"
            },
            {
                "name": "Zhaoyu Gu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, China"
            }
        ],
        "venue": "progress in electromagnetic research symposium",
        "year": 2016
    },
    "XFr45Vbo": {
        "id": "XFr45Vbo",
        "title": "The Construction of Experimental Teaching System for Electronic System Simulation Course Project",
        "abstract": "According to the problems in the experimental teaching of Electronic System Simulation course project,such as deficiency of integration and innovation,insufficiency choices for students,simplex examination means and so on,the construction of the new experimental teaching architecture of the course is explored,combined with characteristics of the course.As a result,the 3+3+3 teaching architecture is presented.And also,the teaching resource construction and the teaching method reformation is researched.",
        "keywords": [
            "experimental teaching system",
            "course project",
            "electronic system simulation"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "BI Li",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "WANG Wei",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electrical & Electronic Education",
        "year": 2012
    },
    "Zxe4B3UX": {
        "id": "Zxe4B3UX",
        "title": "Application of Digital Simulation in Teaching of Radar Principle and System Course",
        "abstract": "Comprehending the physical conceptions is the emphasis and difficulty of the Radar Principle and System course teaching.This paper proposes the idea of applying radar digital simulation system to Radar Principle and System course.The superiority over actual equipments is expatiated,and the configuration,composing,flow chat and functions of the simulation system used in teaching are given,as well as two application examples.Teaching practice results show that the application of simulation system observably enhances the capability of comprehending the physical conceptions,principles and characteristics.",
        "keywords": [
            "teaching practices",
            "digital simulation",
            "radar principle"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "LIU Jin",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electrical & Electronic Education",
        "year": 2012
    },
    "yUCn9J5N": {
        "id": "yUCn9J5N",
        "title": "Optimal guided search based on average discovering time for phased array radar",
        "abstract": "Aimed at optimizing the guided search with forewarning information for phased array radar, this paper builds the targetu0027s average discovering time model based on the probability of the target locating at each beam position. The optimal search parameters are got under the condition of single target and multi-targets respectively. Simulations prove that this optimal method achieves better search performance than the traditional sequential scanning.",
        "keywords": "",
        "authors": [
            {
                "name": "Qihua Wu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, P.R China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, P.R China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, P.R China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, P.R China"
            },
            {
                "name": "Shunping Xiao",
                "org": "State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defense Technology, Changsha, P.R China"
            }
        ],
        "venue": "ieee international radar conference",
        "year": 2016
    },
    "eiWBnbJR": {
        "id": "eiWBnbJR",
        "title": "A Novel Strategy for Pulse Radar HRRP Reconstruction Based on Randomly Interrupted Transmitting and Receiving in Radio Frequency Simulation",
        "abstract": "Target probing based on wideband pulse radar is a challenging task for radio frequency simulation (RFS) in anechoic chamber. Due to the long time duration of pulse radar signal and the limited space of anechoic chamber, the reflected signal returns before the pulse radar signal is fully transmitted, which makes it difficult for the signal reception. As a consequence, the target high-resolution range profile (HRRP) cannot be obtained for target imaging and recognition. In this paper, we propose a novel strategy that contains two steps to solve this problem and obtain the target HRRP. First, the randomly interrupted transmitting and receiving (R-ITR) method is proposed to receive the pulse radar signal in RFS. Second, the target HRRP is reconstructed by compressive sensing (CS) since the R-ITR echo is piecewise sparse. The protocol to choose R-ITR parameters and performance of HRRP reconstruction are provided. Simulations and experiments with different R-ITR parameters are also conducted to verify the effectiveness of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Jin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Guoyu Wang",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            }
        ],
        "venue": "IEEE Transactions on Antennas and Propagation",
        "year": 2018
    },
    "dis0DWhy": {
        "id": "dis0DWhy",
        "title": "Integrative Estimation of Ballistic Target\u2032s Dimension Based on HRRP",
        "abstract": "Estimating targets' dimension using high resolution range profile(HRRP) is an important means of character extraction and target recognition of ballistic missile mid-course defense radars.In this paper,the classic methods based on spectrum estimation are introduced,as well as their concrete flow.And then a new integrated method is brought forward,which combines the fourier method and the super-resolution method and takes advantage of both.The integrated method can effectively solve the problem existing in the single spectrum method that the estimation precision of model order and scatter position cannot be improved synchronously.Finally,simulation results based on simulation data are given,which validates the validity of the integrated method by comparing the performance.",
        "keywords": [
            "ballistic targets",
            "character extraction",
            "dimension estimation",
            "target recognition",
            "high resolution range profile"
        ],
        "authors": [
            {
                "name": "BI Li",
                "org": "School of Electronic Science and Engineering,NUDT, Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,NUDT, Changsha ,China"
            },
            {
                "name": "GAO Xun-zhang",
                "org": "School of Electronic Science and Engineering,NUDT, Changsha ,China"
            },
            {
                "name": "LI Xiang",
                "org": "School of Electronic Science and Engineering,NUDT, Changsha ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2009
    },
    "N1UMmSoK": {
        "id": "N1UMmSoK",
        "title": "Feature Extraction of Precession Targets Using Multi-aspect Observed HRRP Sequences",
        "abstract": "A novel algorithm for feature extraction of the precession angle and real length of the ballistic target using multi-aspect observed High Range Resolution Profile(HRRP) sequences is proposed.Taking the cone-shaped ballistic target into consideration,this paper analyzes the HRRP length when the target is precessing and indicates that the sequence of HRRP lengths can be approximate to a sinusoid function.Then,the model of multi-aspect observation is introduced and a novel algorithm,which is based on the multi-aspect observed HRRP sequences,is proposed to estimate the precession angle and real target length jointly.Afterwards,the effect of the radars' distribution on the estimated errors is discussed.Finally,the simulation results are given for validating the proposed algorithms.",
        "keywords": [
            "High Range Resolution Profile(HRRP)",
            "Ballistic target",
            "Feature extraction",
            "Multi-aspect observation"
        ],
        "authors": [
            {
                "name": "Ai Xiao-feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Li Yong-zhen",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhao Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Xiao Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2011
    },
    "GDWRzagq": {
        "id": "GDWRzagq",
        "title": "A New Method of Radial Velocity Measurement in the Case of High Coupling Coefficient",
        "abstract": "On the basis of such principle as LFM range-Doppler coupling and pulse compress,a new method of radial velocity measurement using single pulse is presented.Pulses which are not frequency overlapped are composed temporally.And through frequency selection characteristics of pulse compress,different range information in condition of different range-Doppler coefficient is obtained.The radial velocity is then obtained through the equation group constructed using the range information.The method solves such problems as range-Doppler modification,data association and trajectory construction for the case of high coupling coefficient.The simulation result of missile defense radar verifies the efficiency.",
        "keywords": [
            "radial velocity",
            "LFM signal",
            "range-Doppler coupling"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": " School of Electronic Science and Engineering,National University of Defense Technology,Changsha "
            },
            {
                "name": "WANG Xue-song",
                "org": " School of Electronic Science and Engineering,National University of Defense Technology,Changsha "
            },
            {
                "name": "XIAO Shun-ping",
                "org": " School of Electronic Science and Engineering,National University of Defense Technology,Changsha "
            }
        ],
        "venue": "Signal Processing",
        "year": 2008
    },
    "emXSTYx2": {
        "id": "emXSTYx2",
        "title": "Data-driven method of reverse modelling for multi-function radar.",
        "abstract": "The common researches for radar system modelling are mostly based on deductive methods, which forward simulate the radar working process according to the information of radar parameters and expert system. However, the radar prior information obtained is limited under battlefield background. So it is difficult to model the radar operating modes and schedule schemes accurately, especially for the multi-function radars (MFRs) which are able to employ multiple modes flexibly. A novel method of reverse modelling for MFR is proposed. The information of the waveform is translated into grammar according to the theory of formal language, and the corresponding Finite-state Automaton (FSA) is composed as initialization. Then, according to the thought of data-driven, the transition relations and probabilities between MFR modes are yielded by analysing the intercepted signals. Finally, the stochastic finite automaton (SFA) is composed, achieving the MFR model by reverse modelling. Simulation with hypothetical MFR signal data is presented, showing that the proposed method is able to compose its SFA effectively, which can be used in MFR state recognition to support the adaptive radar countermeasures.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Ou",
                "org": "Key Laboratory of Complex Electromagnetic Environment, Effects on Electronics and Information System, NUDT, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Feng Zhao",
                "org": "Key Laboratory of Complex Electromagnetic Environment, Effects on Electronics and Information System, NUDT, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "Key Laboratory of Complex Electromagnetic Environment, Effects on Electronics and Information System, NUDT, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Jianhua Yang",
                "org": "Key Laboratory of Complex Electromagnetic Environment, Effects on Electronics and Information System, NUDT, Changsha, Hunan, P. R. China"
            },
            {
                "name": "Yongguang Chen",
                "org": "Beijing Institute of Tracking & Telecommunications Technology, Beijing, P. R. China"
            }
        ],
        "venue": "EUSIPCO",
        "year": 2017
    },
    "q1GkM1xK": {
        "id": "q1GkM1xK",
        "title": "Improvement of resolution of spatially coherent multistatic radar",
        "abstract": "Aiming at radar detection of multiple unresolved targets,considering a multistatic radar system with single transmitter and multiple receivers,an ambiguity function for spatially coherent multistatic radar is analyzed,and then sensor geometrical configuration and waveform selection are used to shape the ambiguity function so as to improve the target resolution.The 3-dB projected contour area of the ambiguity function is used as a measurement to compare the range resolution performance of different sensor geometrical configurations and waveform selections with a spatially incoherent multistatic radar,and relevant simulation results are presented.The conclusion of this paper can be used in the analysis of the multistatic radar detection performance of multiple unresolved targets,and will supply the sensor placement and waveform design of multistatic radars with reference.",
        "keywords": [
            "spatially coherent",
            "multistatic radar",
            "ambiguity function",
            "resolution"
        ],
        "authors": [
            {
                "name": "MIN Tao",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "ZHAO Feng",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "Institute of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Systems Engineering and Electronics",
        "year": 2012
    },
    "3J6Ztx1Y": {
        "id": "3J6Ztx1Y",
        "title": "Two-Dimensional Blanket Jamming Against ISAR Using Nonperiodic ISRJ",
        "abstract": "Interrupted sampling repeater jamming (ISRJ) against inverse synthetic aperture radar (ISAR) attracts great attention in the past decades. Conventional ISRJ mainly produces multiple false targets by periodically sampling and retransmitting the intercepted radar signal at sub-Nyquist rates. However, the rapid development of the anti-ISRJ technique and the difficulty in guaranteeing the real-time reaction make it urgent to propose novel ISRJ-based jamming methods. In this paper, a blanket jamming method against ISAR is proposed by utilizing the unique property of the nonperiodic ISRJ. By nonperiodic interrupted sampling modulation on the intercepted ISAR signal in both fast- and slow-time domains, the target image will be covered by the square-shaped jamming strips spreading along both the range and azimuth direction. Then, the target can get shielded by the two-dimensional blanket jamming. Besides, the proposed method is more effective compared with the conventional blanket jamming method, such as the noise jamming due to the signal coherence. Simulations via the Yak-42 aircraft data demonstrate the validity of the proposed method.",
        "keywords": [
            "Jamming",
            "Modulation",
            "Time-domain analysis",
            "Strips",
            "Radar imaging",
            "Azimuth"
        ],
        "authors": [
            {
                "name": "Qihua Wu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Feng Zhao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Xiaobin Liu",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            },
            {
                "name": "Shunping Xiao",
                "org": "State Key Laboratory of Complex Electromagnetic Environmental Effects on Electronics and Information System, National University of Defense Technology, Changsha, China"
            }
        ],
        "venue": "IEEE Sensors Journal",
        "year": 2019
    },
    "eSWM6yVQ": {
        "id": "eSWM6yVQ",
        "title": "Feature extraction of wobbling rotational symmetry targets",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "Xiaofeng Ai",
                "org": "national university of defense technology"
            },
            {
                "name": "Yongzhen Li",
                "org": "national university of defense technology"
            },
            {
                "name": "Dejun Feng",
                "org": "national university of defense technology"
            },
            {
                "name": "Feng Zhao",
                "org": "national university of defense technology"
            },
            {
                "name": "Shunping Xiao",
                "org": "national university of defense technology"
            }
        ],
        "venue": "IGARSS",
        "year": 2015
    },
    "MdSEKeq8": {
        "id": "MdSEKeq8",
        "title": "Residual-based discrimination method of exoatmospheric active decoys",
        "abstract": "Aiming at dealing with exoatmospheric active decoys, a residual-based discrimination method is proposed. Firstly, dynamics models of active decoys are derived theoretically and the inherent motion differences between warhead and decoys are analyzed. We point out that these motion differences can be reflected by maximum likelihood (ML) estimate residuals of initial state parameter. Secondly, for solving the ML problem, a Levenberg-Marquardt (L-M) algorithm is employed. Finally, the discrimination threshold is designed based on normalized residual sum of square (NRSS). Theoretical analysis and experimental results indicate that the discrimination method is valid and feasible.",
        "keywords": [
            "ballistics",
            "maximum likelihood estimation",
            "missiles",
            "levenberg-marquardt algorithm",
            "exoatmospheric active decoys",
            "initial state parameter",
            "maximum likelihood estimate residuals",
            "normalized residual sum of square",
            "residual-based discrimination method",
            "active decoy",
            "ballistic missile defense(bmd)",
            "discrimination",
            "dynamics model",
            "maximum likelihood estimate",
            "residual",
            "maximum likelihood",
            "levenberg marquardt",
            "sum of squares"
        ],
        "authors": [
            {
                "name": "bin rao",
                "org": "national university of defense technology"
            },
            {
                "name": "xuesong wang",
                "org": "national university of defense technology"
            },
            {
                "name": "feng zhao",
                "org": "national university of defense technology"
            },
            {
                "name": "tao wang",
                "org": "national university of defense technology"
            },
            {
                "name": "shunping xiao",
                "org": "national university of defense technology"
            }
        ],
        "venue": "Bordeaux",
        "year": 2009
    },
    "cO6yWJVv": {
        "id": "cO6yWJVv",
        "title": "Bistatic Micro-Doppler Feature of the Precessing Cone-shaped Warhead",
        "abstract": "Micro-motion feature is one of the effective features used for radar target recognition in the middle section of the ballistic curve.Using the scattering centers of the cone-shaped warhead analyzed by the Geometrical Theory of Diffraction(GTD),it is concluded that the cone-shaped warhead has three scattering centers,one is at the conical point,and the other two are the points where the projection of the bistatic bisector on the conical bottom intersects the edge of the conical bottom,firstly.Then the micro-Doppler(m-D) models of the scattering center at the conical point and two slip-type scattering centers on the edge are derived.They are similar with the monostatic m-D models of the scattering centers when the radar locates on the bistatic bisector,and the amplitude ratio of the m-D in the bistatic radar and monostatic radar is the cosine of the half of the bistatic angle.It coincides with the monostatic-bistatic equivalence theorem.Three correlations of the m-D of the three scattering centers are founded by analyzing their m-D expressions.Finally,the bistatic Radar Cross Section(RCS) of the cone-shaped warhead model are calculated by using FEKO.The theoretic analysis of the m-D expressions is verified from the time-frequency analysis on the bistatic scattering coefficients.",
        "keywords": [
            "Bistatic radar",
            "Sliding scattering center",
            "Radar target recognition",
            "micro-Doppler(m-D)",
            "Geometrical Theory of Diffraction(GTD)"
        ],
        "authors": [
            {
                "name": "Zou Xiao-hai",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Ai Xiao-feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Li Yong-zhen",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Zhao Feng",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            },
            {
                "name": "Xiao Shun-ping",
                "org": "School of Electronic Science and Engineering,National University of Defense Technology,Changsha ,China"
            }
        ],
        "venue": "Journal of Electronics & Information Technology",
        "year": 2012
    },
    "MYtzo29E": {
        "id": "MYtzo29E",
        "title": "Novel method for radar word extraction in the syntactic model of multi-function radar",
        "abstract": "Pulse sequence analysis is a crucial part in the research on multi-function radar (MFR) behaviours. It is the base for MFR behaviour recognition and prediction to extract radar words accurately from the intercepted radar pulse sequence. The common radar word extraction methods are only based on the time-of-arrival (TOA) of pulses, which perform not well when dealing with the complex signals with multiple parameters changing. An improved approach for MFR word extraction is proposed. With the fusion of multiple pulse parameters, radar words are extracted by the steps of quantization coding, matched filtering and word extraction decision utilizing the intercepted signals. Simulation with hypothetical MFR signal data is presented, showing that the proposed method is able to extract the radar words effectively and not sensitive to the missed or spur pulses. The extracted radar words can be used in MFR state recognition to support the adaptive radar countermeasures.",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Ou",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, 410073 Changsha, CHINA"
            },
            {
                "name": "Yongguang Chen",
                "org": "Beijing Institute of Tracking & Telecommunications Technology, 100094, CHINA"
            },
            {
                "name": "Feng Zhao",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, 410073 Changsha, CHINA"
            },
            {
                "name": "Xiaofeng Ai",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, 410073 Changsha, CHINA"
            },
            {
                "name": "Jianhua Yang",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, 410073 Changsha, CHINA"
            },
            {
                "name": "Qihua Wu",
                "org": "Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System, National University of Defence Technology, 410073 Changsha, CHINA"
            }
        ],
        "venue": "international radar symposium",
        "year": 2017
    },
    "Cs01SK83": {
        "id": "Cs01SK83",
        "title": "A Study on Optimal Search Region of Radar under Guidance of Warning Information",
        "abstract": "In this paper,an optimal search region model for tracking and guiding radars based on cuing information is proposed.It optimizes both the static dividing and dynamic refreshing of the radar's search region.The method makes the radar capable of covering continuously the distribution area of the target in high speed movement,and improves the detection performance of the radar.Finally,simulation results confirm the validity of the model.",
        "keywords": [
            "tracking and guiding radar",
            "warning information",
            "ballistic missile defense",
            "search region",
            "high speed movement"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "ZHOU Ying",
                "org": "63880 Unit of PLA,Luoyang ,China"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "WANG Guo-yu",
                "org": "63880 Unit of PLA,Luoyang ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2008
    },
    "3fp8qQfR": {
        "id": "3fp8qQfR",
        "title": "Improved ISRJ-Based Radar Target Echo Cancellation Using Frequency Shifting Modulation",
        "abstract": "Target echo cancellation is an ingenious method that protects the target of interest (TOI) from being detected by radar. Interrupted-sampling repeater jamming (ISRJ) is a novel deception jamming method for linear frequency modulation (LFM) radar countermeasures, which has been applied in target echo cancellation recently. Compared with the conventional cancellation method, not only can the target echo be successfully cancelled at radar receiver, but a train of false targets is also produced and forms deception jamming by applying the ISRJ technique. In this paper, an improved radar target echo cancellation method based on ISRJ is proposed that utilizes an extra frequency shifting modulation on the intercepted LFM radar signal. The jammer power is more efficiently utilized by the proposed method. Moreover, more flexible multi-false-target deception jamming can be obtained by adjusting the interrupted sampling frequency. The real target remains effectively protected by the false preceding target in the presence of amplitude mismatch of cancellation signal and target echo. Numerical simulations and measured data experiments are conducted to demonstrate the effectiveness of the proposed method.",
        "keywords": "",
        "authors": [
            {
                "name": "Qihua Wu",
                "org": ""
            },
            {
                "name": "Feng Zhao",
                "org": ""
            },
            {
                "name": "Junjie Wang",
                "org": ""
            },
            {
                "name": "Xiaobin Liu",
                "org": ""
            },
            {
                "name": "Shunping Xiao",
                "org": ""
            }
        ],
        "venue": "Electronics",
        "year": 2019
    },
    "8zQyPWvR": {
        "id": "8zQyPWvR",
        "title": "Polarization Suppression of Active Interference in the Middle Part of Missile Trajectory",
        "abstract": "The precession character of the decoy in the middle part of the missile trajectory is analyzed.Based on this analysis, the polarization ehanging regulation of the radar received interference is studied.The polarization suppression method is proposed by this studv.In this method,firstly the precession character of the decoy is estimated using the interference polarization data.Then,the polarization changing is predicted using the precession parameters.Finally,the interference is suppressed by the transform of the receiving polarization of radar.Contrasted with the traditional polarization suppression method,the major improvement of this method is that the polarization changing of the interference signal,which is produced by the decoy precession,is tracked.So the performance of this method is better than the traditional ones.The performance of this polarization suppression method is testified by the simulation.",
        "keywords": [
            "interference suppression",
            "polarization",
            "active interference",
            "precession",
            "middle part of missile trajectory"
        ],
        "authors": [
            {
                "name": "CHANG Yu-liang",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha,Hunan,"
            },
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha,Hunan,"
            },
            {
                "name": "DAI Da-hai",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha,Hunan,"
            },
            {
                "name": "WANG Xue-song",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha,Hunan,"
            }
        ],
        "venue": "Signal Processing",
        "year": 2009
    },
    "zV4S1Tkp": {
        "id": "zV4S1Tkp",
        "title": "A Study on Optimal Search Order of Anti-missile Tracking Radars",
        "abstract": "The high speed movement of the ballistic missile has brought enormous challenge to the tracking and guiding radars in ballistic missile defense system.In this paper,an optimal search beam order model of phased array radar based on probability trajectories is proposed.In this method,the distribution of the position and velocity of the target is treated equally as several trajectories,along each of which the target will fly with certain probability,and these are so-called probability trajectories.The fallen in probabilities of targets can be obtained dynancically with recursive calculation and refresh of the probability of each trajectory in real time.Based on above,the search beam order can be decided using the rule of maximal cumulative detection probability.Finally,simulation results are given,which adequately validate that the model proposed in this paper has performances under the condition of high speed targets is better than that of the traditional optimal search model.",
        "keywords": [
            "tracking and guiding radar",
            "accumulated probability of detection",
            "probability trajectory",
            "ballistic missile defense",
            "optimal search order"
        ],
        "authors": [
            {
                "name": "ZHAO Feng",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "BI Li",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "YANG Jian-hua",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            },
            {
                "name": "XIAO Shun-ping",
                "org": "School of Electronic Science and Engineering,NUDT,Changsha ,China"
            }
        ],
        "venue": "Modern Radar",
        "year": 2009
    },
    "naYZvL4n": {
        "id": "naYZvL4n",
        "title": "Data-driven method of reverse modelling for multi-function radar.",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Jian Ou",
                "org": ""
            },
            {
                "name": "Feng Zhao",
                "org": ""
            },
            {
                "name": "Xiaofeng Ai",
                "org": ""
            },
            {
                "name": "Jianhua Yang",
                "org": ""
            },
            {
                "name": "Yongguang Chen",
                "org": ""
            }
        ],
        "venue": "EUSIPCO",
        "year": 2017
    },
    "YPGLWowa": {
        "authors": [
            {
                "name": "Liping Li",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Rui Wang",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Wanwen Liang",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Xi Gan",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Ting Huang",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Yan Huang",
                "org": "Centers for Disease Control and Prevention"
            },
            {
                "name": "Jian Li",
                "org": "Institute of Animal Science and Technology"
            },
            {
                "name": "Yunliang Shi",
                "org": "Institute of Animal Science and Technology"
            },
            {
                "name": "Ming Chen",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Honglin Luo",
                "org": "Guanxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            }
        ],
        "title": "Rare serotype occurrence and PFGE genotypic diversity of Streptococcus agalactiae isolated from tilapia in China",
        "abstract": "Previously, we reported 10 PEGE types of 85 tilapia Streptococcus agalactiae (GBS), which shifted from Streptococcus iniae in China, by using PEGE method. Presently, larger and more representative tilapia GBS were isolated, for the first time in China, to characterize their serotypes and genetic diversities more precisely than had done before. 168 GBS strains were distributed in five provinces of China, in which Guangdong, Guangxi and Hainan were the major ones, holding 36.9% (62/168), 37.5% (63/168) and 19.6% (33/168), respectively. Serotypes, Ia, Ib and III, were observed in these strains and the most predominant one was Ia (95.2%), which mainly distributed in Guangdong, Guangxi and Hainan. Ia initially occurred in 2009, it shoot up to 32.1% in 2010, but decreased to 16.1% in 2011 before went up to 45.2% in 2012. Ib sporadically occurred during 2007-2011, III only occurred in 2012. 14 different PFGE types, including 4 new types (N, O, P and Q), were observed, in which B, D, F and G were the predominant types, holding 83.9% (141/168) of the total GBS strains. Ia corresponded to 11 PFGE types (A-H, N-P), in which type D predominated (51%). Ib represented 3 genotypes (I, J and Q) and III harbored only 2 genotypes (N and F). Type N and F synchronously presented in Ia and III. In summary, the genetic diversity of tilapia GBS varied by serotypes and changed with geographical locations and years. Although Ia still predominated, new rare serotype III already occurred in China. \u00a9 2013 Elsevier B.V.",
        "keywords": [
            "Genotypes",
            "Serotypes",
            "Streptococcus agalactiae",
            "Tilapia"
        ],
        "venue": "Veterinary Microbiology",
        "year": 2013,
        "id": "YPGLWowa"
    },
    "DYzOt3Xh": {
        "authors": [
            {
                "name": "Rui Wang",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Liping Li",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Yan Huang",
                "org": "Guangxi Center for Disease Control and Prevention"
            },
            {
                "name": "Fuguang Luo",
                "org": "Liuzhou's Aquaculture Technology Extending Station"
            },
            {
                "name": "Wanwen Liang",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Xi Gan",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Ting Huang",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Aiying Lei",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Ming Chen",
                "org": "Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Lianfu Chen",
                "org": "Huazhong Agricultural University"
            }
        ],
        "title": "Comparative genome analysis identifies two large deletions in the genome of highly-passaged attenuated Streptococcus agalactiae strain YM001 compared to the parental pathogenic strain HN016",
        "abstract": "Background: Streptococcus agalactiae (S. agalactiae), also known as group B Streptococcus (GBS), is an important pathogen for neonatal pneumonia, meningitis, bovine mastitis, and fish meningoencephalitis. The global outbreaks of Streptococcus disease in tilapia cause huge economic losses and threaten human food hygiene safety as well. To investigate the mechanism of S. agalactiae pathogenesis in tilapia and develop attenuated S. agalactiae vaccine, this study sequenced and comparatively analyzed the whole genomes of virulent wild-type S. agalactiae strain HN016 and its highly-passaged attenuated strain YM001 derived from tilapia. Methods: We performed Illumina sequencing of DNA prepared from strain HN016 and YM001. Sequencedreads were assembled and nucleotide comparisons, single nucleotide polymorphism (SNP) , indels were analyzed between the draft genomes of HN016 and YM001. Clustered regularly interspaced short palindromic repeats (CRISPRs) and prophage were detected and analyzed in different S. agalactiae strains. Results: The genome of S. agalactiae YM001 was 2,047,957 bp with a GC content of 35.61 %; it contained 2044 genes and 88 RNAs. Meanwhile, the genome of S. agalactiae HN016 was 2,064,722 bp with a GC content of 35.66 %; it had 2063 genes and 101 RNAs. Comparative genome analysis indicated that compared with HN016, YM001 genome had two significant large deletions, at the sizes of 5832 and 11,116 bp respectively, resulting in the deletion of three rRNA and ten tRNA genes, as well as the deletion and functional damage of ten genes related to metabolism, transport, growth, anti-stress, etc. Besides these two large deletions, other ten deletions and 28 single nucleotide variations (SNVs) were also identified, mainly affecting the metabolism- and growth-related genes. Conclusions: The genome of attenuated S. agalactiae YM001 showed significant variations, resulting in the deletion of 10 functional genes, compared to the parental pathogenic strain HN016. The deleted and mutated functional genes all encode metabolism- and growth-related proteins, not the known virulence proteins, indicating that the metabolism- and growth-related genes are important for the pathogenesis of S. agalactiae.",
        "keywords": [
            "Genetic variation",
            "Sequence analysis",
            "Streptococcus agalactiae",
            "Virulence attenuation",
            "Virulence factors"
        ],
        "venue": "BMC Genomics",
        "year": 2015,
        "id": "DYzOt3Xh"
    },
    "UcBGQj3R": {
        "authors": [
            {
                "name": "Ying-rui Wu",
                "org": "Guangxi Key Laboratory of Functional Photochemical Research and Utilization"
            },
            {
                "name": "Qing-fang Gong",
                "org": "Guangxi Key Laboratory of Functional Photochemical Research and Utilization"
            },
            {
                "name": "Hong Fang",
                "org": "Guangxi Key Laboratory of Functional Photochemical Research and Utilization"
            },
            {
                "name": "Wan-wen Liang",
                "org": "Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Ming Chen",
                "org": "Guangxi Key Laboratory of Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Rui-jie He",
                "org": "Guangxi Key Laboratory of Functional Photochemical Research and Utilization"
            }
        ],
        "title": "Effect of Sophora flavescens on non-specific immune response of tilapia (GIFT Oreochromis niloticus) and disease resistance against Streptococcus agalactiae",
        "abstract": "The paper describes the effect of a diet supplemented with the Chinese traditional herbal medicine Sophora flavescens on the immunity and disease resistance of an Oreochromis niloticus GIFT strain. Experimental diets containing 0.025%, 0.050%, 0.100%, 0.200%, and 0.400% S. flavescens, as well as a control group without S. flavescens were used. We tested the non-specific humoral immune responses (lysozyme, antiprotease, and complement) and cellular immune responses (reactive oxygen species and nitrogen species production and myeloperoxidase), as well as disease resistance against Streptococcus agalactiae. S. flavescens supplementation at all dose significantly enhanced serum lysozyme, antiprotease, and natural hemolytic complement activity. Similarly, all S. flavescens doses enhanced cellular myeloperoxidase activity. The increased production of reactive oxygen species and reactive nitrogen intermediates by peripheral blood leucocytes was observed in most of the treatment groups throughout the test period. The fish fed 0.100% S. flavescens had a percent mortality of 21.1% and a relative percent survival of 73.3% compared with the group fed the basal diet during the S. agalactiae challenge. The results suggest that S. flavescens can be recommended as a tilapia feed supplement to enhance fish immunity and disease resistance against S. agalactiae. \u00a9 2012 Elsevier Ltd.",
        "keywords": [
            "Immune response",
            "Oreochromis niloticus",
            "Sophora flavescens",
            "Streptococcus agalactiae",
            "Survival"
        ],
        "venue": "Fish and Shellfish Immunology",
        "year": 2013,
        "id": "UcBGQj3R"
    },
    "vlyrjl4f": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": "Guangxi Institute of Fisheries"
            },
            {
                "name": "Rui Wang",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "Xi Gan",
                "org": "Guangxi Institute of Fisheries"
            },
            {
                "name": "Aiying Lei",
                "org": "Guangxi Institute of Fisheries"
            },
            {
                "name": "Chao Li",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "Xiaoli Yu",
                "org": "Guangxi Institute of Fisheries"
            },
            {
                "name": "Jun Huang",
                "org": "College of Animal Science and Technology"
            },
            {
                "name": "Ting Huang",
                "org": "Guangxi Institute of Fisheries"
            },
            {
                "name": "Wanwen Liang",
                "org": "Guangxi Institute of Fisheries"
            }
        ],
        "title": "Sequence and expression analysis of the gene encoding inducible cAMP early repressor in tilapia",
        "abstract": "Suppression subtractive hybridization library was generated by comparison of cDNA populations isolated from peripheral leukocytes of pre- and post-immunized tilapia. One cDNA sequence encoding complete inducible cAMP early repressor was obtained from the library. The sequence was characterized by the presence of the basic structure of ICER II\u03b3. Expression of ICER was in the tissues of four types of tilapia was decreased after infection with Streptococcus. After immunization, expression of ICER was initially decreased and then increased after 7 days. In addition, the order for the overall expression of ICER gene after infection and the increases of ICER expression later after immunization in these four types of tilapia was positively correlated to the disease resistance and productivity of these four species of tilapia. Our results provided molecular mechanisms for the different disease resistance capability in different species of tilapia. In addition, our results also provided reference molecular marker for breeding disease resistant tilapia, cAMP responsive element modulator. \u00a9 2009 Springer Science+Business Media B.V.",
        "keywords": [
            "DNA binding domain II (DBDII)",
            "Inducible cAMP early repressor (ICER)",
            "Suppression subtractive hybridization (SSH)",
            "Tilapia"
        ],
        "venue": "Molecular Biology Reports",
        "year": 2010,
        "id": "vlyrjl4f"
    },
    "QtXmG0Qr": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Li-Ping Li",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Rui Wang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Wan-Wen Liang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Yan Huang",
                "org": "Guangxi Center for Disease Control and Prevention"
            },
            {
                "name": "Jian Li",
                "org": "Institute of Animal Science and Technology"
            },
            {
                "name": "Ai-Ying Lei",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Wei-Yi Huang",
                "org": "Institute of Animal Science and Technology"
            },
            {
                "name": "Xi Gan",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            }
        ],
        "title": "PCR detection and PFGE genotype analyses of streptococcal clinical isolates from tilapia in China",
        "abstract": "Large-scale streptococcal outbreaks occurred continuously in tilapia farms of China from 2009 to 2011. The objective of this study was to characterize the prevalent strains of tilapia streptococci from the main cultured areas of China through species specific PCR and pulse field gel electrophoresis (PFGE). A total of 105 prevalent strains were isolated from Guangdong, Guangxi, Hainan and Fujian provinces between 2006 and 2011, 85 of which were identified as Streptococcus agalactiae while the rest were all identified as Streptococcus iniae. The prevalent stains in 2006 and 2007 were S. iniae (94.7%, 18/19), with S. agalactiae account for only 5.3% (1/19); The prevalent strains in 2009 and 2011 however changed to S. agalactiae (97.7%, 84/86), with only 2.3% (2/86) was S. iniae. Of these 105 strains, a total of 13 PFGE types (A-M) were characterized, among which D, F, G and K genotypes were predominant, accounting for 81.90% (86/105). The cluster analysis of PFGE electropherograms separated S. iniae and S. agalactiae to two distinctive branches, 20 strains of S. iniae exhibiting 3 types of PFGE band patterns with a similarity of 94.8-100%, and the 85 strains of S. agalactiae producing 10 types of PFGE band patterns with a similarity between 48.4% and 100%. Data suggested that the prevalent strains of tilapia streptococci in China have shifted from the former (before 2008) dominant strains of S. iniae to the current (2009-2011) dominant strains of S. agalactiae. Moreover, PFGE genotypes of the prevalent strains demonstrated geographic differences and temporal changes. \u00a9 2012.",
        "keywords": [
            "Genotype",
            "PFGE",
            "Streptococcus agalactiae",
            "Streptococcus iniae",
            "Tilapia"
        ],
        "venue": "Veterinary Microbiology",
        "year": 2012,
        "id": "QtXmG0Qr"
    },
    "mhb2OyN4": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": "Institute of Animal Science and Technology, Guangxi University"
            },
            {
                "name": "Rui Wang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Liping Li",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Wanwen Liang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Qiuhua Wang",
                "org": "Institute of Animal Science and Technology, Guangxi University"
            },
            {
                "name": "Ting Huang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Chao Li",
                "org": "Institute of Animal Science and Technology, Guangxi University"
            },
            {
                "name": "Jian Li",
                "org": "Institute of Animal Science and Technology, Guangxi University"
            },
            {
                "name": "Xi Gan",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Aiying Lei",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            },
            {
                "name": "Weiyi Huang",
                "org": "Institute of Animal Science and Technology, Guangxi University"
            },
            {
                "name": "Honglin Luo",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture, Guangxi Academy of Fishery Sciences"
            }
        ],
        "title": "Immunological enhancement action of endotoxin-free tilapia heat shock protein 70 against Streptococcus iniae",
        "abstract": "The immunological effects of heat shock proteins (HSPs) had been found in humans and mice, but scarce data of endotoxin-free Hsp70 were reported in tilapia. In the current study, we reported that tHsp70 alone and antigen-tHsp70 compound increased the proliferations of lymphocytes and macrophages, significantly increased the NO release and phagocytotic ability of macrophages (p<. 0.05), and enhanced the levels of immune-related genes in lymphocytes and macrophages in a dose- and/or time-dependent manner. On the other hand, tHsp70 not only helped to reduce the proliferation inhibitions induced by the ECP treatment, but also assisted antigens to enhance the vaccine-induced protection against Streptococcus iniae (p<. 0.05). We described, for the first time, a critical role of endotoxin-free tHsp70 on activation of tilapia lymphocytes and macrophages post S. iniae exposure and its up-regulation effects on vaccine-induced protection. Our research highlights the immunological enhancement action of Hsp70 in teleost immunity. \u00a9 2014.",
        "keywords": [
            "Heat shock protein 70",
            "Lymphocytes",
            "Macrophages",
            "Streptococcus iniae",
            "Tilapia"
        ],
        "venue": "Cellular Immunology",
        "year": 2014,
        "id": "mhb2OyN4"
    },
    "6M24T8fy": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": ""
            },
            {
                "name": "Rui Wang",
                "org": ""
            },
            {
                "name": "Fu-Guang Luo",
                "org": ""
            },
            {
                "name": "Yan Huang",
                "org": ""
            },
            {
                "name": "Wan-Wen Liang",
                "org": ""
            },
            {
                "name": "Ting Huang",
                "org": ""
            },
            {
                "name": "Ai-Ying Lei",
                "org": ""
            },
            {
                "name": "Xi Gan",
                "org": ""
            },
            {
                "name": "Li-Ping Li",
                "org": ""
            }
        ],
        "title": "Streptococcus agalactiae isolates of serotypes Ia, III and V from human and cow are able to infect tilapia",
        "abstract": "Recent studies have shown that group B streptococcus (GBS) may be infectious across hosts. The purpose of this study is to investigate the pathogenicity of clinical GBS isolates with serotypes Ia, III and V from human and cow to tilapia and the evolutionary relationship among these GBS strains of different sources. A total of 27 clinical GBS isolates from human (n= 10), cow ( n= 2) and tilapia (n= 15) were analyzed using serotyping, multi-locus sequence typing (MLST) and pulsed-field gel electrophoresis (PFGE). Among them, 15 isolates were tested for their pathogenicity to tilapia. The results showed that five human GBS strains (2 serotype III, 2 serotype Ia and 1 serotype V) infected tilapia with mortality rate ranging from 56.67% to 100%, while the other five human GBS strains tested were unable to infect tilapia. In addition, two cow GBS strains C001 and C003 of serotype III infected tilapia. However, they had significantly lower pathogenicity than the five human strains. Furthermore, human GBS strains H005 and H008, which had very strong ability to infect tilapia, had the same PFGE pattern. MLST analysis showed that the five human and the two cow GBS strains that were able to infect tilapia belonged to clonal complexes CC19, CC23 and CC103. The study for the first time confirmed that human or cow GBS clonal complexes CC19, CC23 and CC103 containing strains with serotypes Ia, III and V could infect tilapia and induce clinical signs under experimental conditions.",
        "keywords": [
            "Cow",
            "Human",
            "MLST",
            "Pathogenicity",
            "PFGE",
            "Streptococcus agalactiae",
            "Tilapia"
        ],
        "venue": "Veterinary Microbiology",
        "year": 2015,
        "id": "6M24T8fy"
    },
    "QXvg4Mva": {
        "authors": [
            {
                "name": "Ming Chen",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Rui Wang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Li-Ping Li",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Wan-Wen Liang",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Jian Li",
                "org": "Institute of Animal Science and Technology"
            },
            {
                "name": "Yan Huang",
                "org": "Guangxi Center for Disease Control and Prevention"
            },
            {
                "name": "Ai-Ying Lei",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            },
            {
                "name": "Wei-Yi Huang",
                "org": "Institute of Animal Science and Technology"
            },
            {
                "name": "Xi Gan",
                "org": "Guangxi Key Laboratory for Aquatic Genetic Breeding and Healthy Aquaculture"
            }
        ],
        "title": "Screening vaccine candidate strains against Streptococcus agalactiae of tilapia based on PFGE genotype",
        "abstract": "The immunogenicity identification of epidemic strain is important for the development and application of vaccine. In this study, 85 Streptococcus agalactiae prevalent strains from the tilapia main cultured areas of China were distributed among 10 distinct PFGE genotypes (A-J). For each genotype, one representative strain (S.a",
        "keywords": [
            "PFGE",
            "Serotype",
            "Streptococcus agalactiae",
            "Tilapia",
            "Vaccine candidate strain"
        ],
        "venue": "Vaccine",
        "year": 2012,
        "id": "QXvg4Mva"
    },
    "Uf0bUfaA": {
        "id": "Uf0bUfaA",
        "title": "Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors.",
        "abstract": "Bone nonunion may occur when the fracture is unstable, or blood supply is impeded. To provide an effective treatment for the healing of nonunion defects, we introduce an injectable osteogenic hydrogel that can deliver cells and vasculogenic growth factors. We used a silicate-based shear-thinning hydrogel (STH) to engineer an injectable scaffold and incorporated polycaprolactone (PCL) nanoparticles that entrap and release vasculogenic growth factors in a controlled manner. By adjusting the solid composition of gelatin and silicate nanoplatelets in the STH, we defined optimal conditions that enable injection of STHs, which can deliver cells and growth factors. Different types of STHs could be simultaneously injected into 3D constructs through a single extrusion head composed of multiple syringes and needles, while maintaining their engineered structure in a continuous manner. The injected STHs were also capable of filling any irregularly shaped defects in bone. Osteogenic cells and endothelial cells were encapsulated in STHs with and without vasculogenic growth factors, respectively, and when co-cultured, their growth and differentiation were significantly enhanced compared to cells grown in monoculture. This study introduces an initial step of developing a new platform of shape-tunable materials with controlled release of angiogenic growth factors by utilizing PCL nanoparticles.",
        "keywords": "",
        "authors": [
            {
                "name": "Emine Alar\u00e7in",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey."
            },
            {
                "name": "Tae Yong Lee",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea."
            },
            {
                "name": "Sobha Karuthedom",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Marzieh Mohammadi",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Meadhbh A Brennan",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and INSERM, UMR 1238, PHYOS, Faculty of Medicine, University of Nantes, Nantes, France."
            },
            {
                "name": "Dong Hoon Lee",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Alessandra Marrella",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Jin Zhang",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Denata Syla",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Yu Shrike Zhang",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA."
            },
            {
                "name": "Ali Khademhosseini",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA and Department of Bioindustrial Technologies, College of Animal Bioscience & Technology, Konkuk University, Seoul 143-701, Republic of Korea and Center of Nanotechnology, Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia and Department of Bioengineering, Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, USA and Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA and Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, USA and California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA, USA."
            },
            {
                "name": "Hae Lin Jang",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA."
            }
        ],
        "venue": "Biomaterials science",
        "year": 2018
    },
    "NTwhEyX2": {
        "id": "NTwhEyX2",
        "title": "Development of nanomaterials for bone-targeted drug delivery",
        "abstract": "Bone is one of the major organs of the human body; it supports and protects other organs, produces blood cells, stores minerals, and regulates hormones. Therefore, disorders in bone can cause serious morbidity, complications, or mortality of patients. However, despite the significant occurrence of bone diseases, such as osteoarthritis (OA), osteoporosis (OP), non-union bone defects, bone cancer, and myeloma-related bone disease, their effective treatments remain a challenge. In this review, we highlight recent progress in the development of nanotechnology-based drug delivery for bone treatment, based on its improved delivery efficiency and safety. We summarize the most commonly used nanomaterials for bone drug delivery. We then discuss the targeting strategies of these nanomaterials to the diseased sites of bone tissue. We also highlight nanotechnology-based drug delivery to bone cells and subcellular organelles. We envision that nanotechnology-based drug delivery will serve as a powerful tool for developing treatments for currently incurable bone diseases.",
        "keywords": "",
        "authors": [
            {
                "name": "Hao Cheng",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Hao Cheng",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Hao Cheng",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Aditya Chawla",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Aditya Chawla",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Aditya Chawla",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Yafeng Yang",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Yafeng Yang",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Yuxiao Li",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Yuxiao Li",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Jin Zhang",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Jin Zhang",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            },
            {
                "name": "Hae Lin Jang",
                "org": ""
            },
            {
                "name": "Hae Lin Jang",
                "org": ""
            },
            {
                "name": "Hae Lin Jang",
                "org": ""
            },
            {
                "name": "Ali Khademhosseini",
                "org": "Division of Biomedical Engineering, Department of Medicine, Biomaterials Innovation Research Center, Harvard Medical School, Brigham & Women\u2019s Hospital, Boston, MA 02139, USA"
            }
        ],
        "venue": "Drug Discovery Today",
        "year": 2017
    },
    "DaEF2yku": {
        "id": "DaEF2yku",
        "title": "Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors.",
        "abstract": "Bone nonunion may occur when the fracture is unstable, or blood supply is impeded. To provide an effective treatment for the healing of nonunion defects, we introduce an injectable osteogenic hydrogel that can deliver cells and vasculogenic growth factors. We used a silicate-based shear-thinning hydrogel (STH) to engineer an injectable scaffold and incorporated polycaprolactone (PCL) nanoparticles that entrap and release vasculogenic growth factors in a controlled manner. By adjusting the solid composition of gelatin and silicate nanoplatelets in the STH, we defined optimal conditions that enable injection of STHs, which can deliver cells and growth factors. Different types of STHs could be simultaneously injected into 3D constructs through a single extrusion head composed of multiple syringes and needles, while maintaining their engineered structure in a continuous manner. The injected STHs were also capable of filling any irregularly shaped defects in bone. Osteogenic cells and endothelial cells were encapsulated in STHs with and without vasculogenic growth factors, respectively, and when co-cultured, their growth and differentiation were significantly enhanced compared to cells grown in monoculture. This study introduces an initial step of developing a new platform of shape-tunable materials with controlled release of angiogenic growth factors by utilizing PCL nanoparticles.",
        "keywords": "",
        "authors": [
            {
                "name": "Emine Alar\u00e7in",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Department of Pharmaceutical Technology, Faculty of Pharmacy, Marmara University, Istanbul 34668, Turkey."
            },
            {
                "name": "Tae Yong Lee",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea."
            },
            {
                "name": "Sobha Karuthedom",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Marzieh Mohammadi",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Meadhbh A Brennan",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and INSERM, UMR 1238, PHYOS, Faculty of Medicine, University of Nantes, Nantes, France."
            },
            {
                "name": "Dong Hoon Lee",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Alessandra Marrella",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Jin Zhang",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Denata Syla",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA."
            },
            {
                "name": "Yu Shrike Zhang",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA."
            },
            {
                "name": "Ali Khademhosseini",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA and Department of Bioindustrial Technologies, College of Animal Bioscience & Technology, Konkuk University, Seoul 143-701, Republic of Korea and Center of Nanotechnology, Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia and Department of Bioengineering, Department of Chemical and Biomolecular Engineering, Henry Samueli School of Engineering and Applied Sciences, University of California-Los Angeles, Los Angeles, CA, USA and Department of Radiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, USA and Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA, USA and California NanoSystems Institute (CNSI), University of California-Los Angeles, Los Angeles, CA, USA."
            },
            {
                "name": "Hae Lin Jang",
                "org": "Division of Engineering in Medicine, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Cambridge, MA 02139, USA. yszhang@research.bwh.harvard.edu khademh@ucla.edu hjang@bwh.harvard.edu and Division of Health Sciences & Technology, Harvard-Massachusetts Institute of Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA."
            }
        ],
        "venue": "Biomaterials science",
        "year": 2018
    },
    "W19uJ5T6": {
        "authors": [
            {
                "name": "Lei Zhang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Su-Qi Li",
                "org": "Department of Chemistry"
            },
            {
                "name": "Dai-Zheng Liao",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zong-Hui Jiang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Shi-Ping Yan",
                "org": "Department of Chemistry"
            },
            {
                "name": "Geng-Lin Wang",
                "org": "Department of Chemistry"
            },
            {
                "name": "Zhi Wang",
                "org": "Stt. Key Lab. of Coord. Chemistry"
            },
            {
                "name": "Pan-Wen Shen",
                "org": "Department of Chemistry"
            },
            {
                "name": "Xin-Kan Yao",
                "org": "Central Laboratory"
            },
            {
                "name": "Hong-Gen Wang",
                "org": "Central Laboratory"
            }
        ],
        "title": "Synthesis, characterization and crystal structures of manganese (II) complexes containing nitronyl nitroxide and its reduced derivative",
        "abstract": "Two novel adducts of formula Mn(hfac)",
        "keywords": [
            "Crystal structures",
            "Manganese(II) complex",
            "Nitronyl nitroxide"
        ],
        "venue": "Chinese Journal of Chemistry",
        "year": 1999,
        "id": "W19uJ5T6"
    },
    "EAALlm1h": {
        "id": "EAALlm1h",
        "title": "Intersphincteric incision with seton at the inner opening plus contra-aperture drainage through the abscess cavity for treatment of horseshoe perianal abscess",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "Shaohua Huangfu",
                "org": ""
            },
            {
                "name": "Bin Jiang",
                "org": ""
            },
            {
                "name": "Yijiang Ding",
                "org": ""
            },
            {
                "name": "Shu-Qing Ding",
                "org": ""
            },
            {
                "name": "Xin Yin",
                "org": ""
            },
            {
                "name": "Qing-Yan Yuan",
                "org": ""
            }
        ],
        "venue": "World Chinese Journal of Digestology",
        "year": 2016
    },
    "iq0QJ9NU": {
        "id": "iq0QJ9NU",
        "title": "Temozolomide resistant human brain tumor stem cells are susceptible to recombinant vesicular stomatitis virus and double-deleted Vaccinia virus in vitro.",
        "abstract": "VSV-\u0394M51and vvDD could infect and kill both the TMZ resistant BTSCs and the differentiated compartments of GBMs in vitro, suggesting that they may be an effective treatment supplement for GBM therapy, particularly for TMZ resistant GBM patients.",
        "keywords": [
            "Double-deleted vaccinia virus",
            "Human brain tumor stem cells",
            "Malignant glioma",
            "Recombinant vesicular stomatitis virus",
            "Temozolomide"
        ],
        "authors": [
            {
                "name": "Bin Jiang",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China."
            },
            {
                "name": "Xueqing Lun",
                "org": "Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, Alberta, Canada."
            },
            {
                "name": "Xiaoguang Hao",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China."
            },
            {
                "name": "Yihua Wang",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China."
            },
            {
                "name": "Xin Yin",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China."
            },
            {
                "name": "Dezhang Huang",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China."
            },
            {
                "name": "Wei He",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China."
            },
            {
                "name": "Zhigang Wang",
                "org": "Department of Neurosurgery, Qilu Hospital of Shandong University, Qingdao 266035, Shandong, China. Electronic address: wzg1110@126.com."
            }
        ],
        "venue": "Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie",
        "year": 2017
    },
    "cXtPe35O": {
        "id": "cXtPe35O",
        "title": "Major Metabolite Levels of Preoperative Proton Magnetic Resonance Sectroscopy and Intraoperative Fluorescence Intensity in Glioblastoma.",
        "abstract": "Objective To compare the intraoperative major metabolite level of preoperative proton magnetic resonance spectroscopy(H-MRS)and fluorescence intensity marked with fluorescein sodium(FLs)in glioblastoma(GBM)and thus provide an objective basis for fluorescence surgical treatment of GBM. Methods All newly diagnosed patients by plain and enhanced magnetic resonance imaging from the April 1,2014 to December 31,2015 were enrolled in this study.All of them received H-MRS and marked with FLs.The expression of Ki67 in tumor boundary were confirmed by postoperative pathology and determined by immunostaining assay.The relationship between H-MRS metabolite levels and tumor fluorescence intensity was analyzed. Results Totally 33 patients were included in the study.Preoperative H-MRS revealed high-grade gliomas in 25 cases.The N-acetylaspartate(NAA)decreased significantly and choline(Cho)increased significantly in high-grade gliomas.The ratios of Cho/NAA,NAA/creatine(Cr),and Cho/Cr significantly differed in different tumor regions(P=0.02,P=0.01,and P=0.00,respectively).Surgical results were marked with FLs intraoperatively.Tissue fluorescence were clearly seen.There were 29 patients undergoing total resection and 4 cases undergoing subtotal resection.No acute encephalocele occured after operation,while 2 patients suffered from epilepsy.Postoperative pathology results included:28 cases were diagnosed as GBM(22 cases consistent with H-MRS diagnosis).The results of GBM fluorescence imaging included:the level of fluorescence intensity in tumor parenchyma was significantly higher than that in tumor boundary and peritumoral edema(P=0.01).The result of H-MRS metabolite analysis included:The kurtosis of NAA and of Cho and the ratio of Cho/NAA were significantly different according the fluorescence intensity in tumor parenchyma(P=0.01,P=0.02,and P=0.01).While there was no difference in the kurtosis of NAA,the kurtosis of Cho and the ratio of Cho/NAA were significantly different according the fluorescence intensity in tumor boundary(P=0.02, P=0.00).In peritumoral edema,there was no significant different in kurtosis of NAA and of Cho and in the ratio of Cho/NAA(P=0.23,P=0.09,P=0.14).Immunohistochemistry in GBM tumor boundary showed different Ki67 expressions according to different fluorescence imaging(P=0.03). Conclusions The fluorescence intensity in GBM parenchyma is higher than that in other tumor regions,and there are different metabolic levels in different fluorescence intensity.The metabolic information marked by FLs and provided by H-MRS before operationis are important,and the correlation between them should be further investigated.",
        "keywords": "",
        "authors": [
            {
                "name": "Hai-Long Tian",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Yu-Liang Zu",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Chao-Chao Wang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Tao Lin",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Zhen-Tao Guo",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Bin Jiang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Xin Yin",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Wen-Qiang Guo",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Zhi-Gang Wang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2017
    },
    "ijvRCs0X": {
        "id": "ijvRCs0X",
        "title": "Sodium Fluorescein-Guided Resection under the YELLOW 560\u2009nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience.",
        "abstract": "FL-guided resection of MGs under the YELLOW 560\u2009nm surgical microscope filter combined with neuronavigation was safe and effective, especially in non-contrast-MRI regions. It is feasible for improving the extent of resection in MGs especially during emergency cases.",
        "keywords": "",
        "authors": [
            {
                "name": "Ningning Zhang",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Hailong Tian",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Dezhang Huang",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Xianbing Meng",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Wenqiang Guo",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Chaochao Wang",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Xin Yin",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Hongying Zhang",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Bin Jiang",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Zheng He",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            },
            {
                "name": "Zhigang Wang",
                "org": "Department of Neurosurgery, Qilu Hospital, Qingdao, China."
            }
        ],
        "venue": "BioMed research international",
        "year": 2017
    },
    "k3qkUkdx": {
        "id": "k3qkUkdx",
        "title": "Corrigendum to \u201cSodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience\u201d",
        "abstract": "Objective. Sodium fluorescein (FL) had been safely used in fluorescence-guided microsurgery for imaging various brain tumors. Under the YELLOW 560\u2009nm surgical microscope filter, low-dose FL as a fluorescent dye helps in visualization. Our study investigated the safety and efficacy of this innovative technique in malignant glioma (MG) patients. Patients and Method. 38 patients suffering from MGs confirmed by pathology underwent FL-guided resection under YELLOW 560\u2009nm surgical microscope filter. We retrospectively analyzed the clinical characters, microsurgery procedure, extent of resection, pathology of MGs, progression-free survival (PFS), and overall survival (OS). Results. Thirty-eight patients had MGs (10 WHO grade III, 28 WHO grade IV). With YELLOW 560\u2009nm surgical microscope filter combined with neuronavigation, sodium fluorescein-guided gross total resection (GTR) was achieved in 35 (92.1%) patients and subtotal resection in 3 (7.69%). The sensitivity and specificity of FL were 94.4% and 88.6% regardless of radiographic localization. Intraoperatively, 10 biopsies (10/28 FL[",
        "keywords": "",
        "authors": [
            {
                "name": "Ningning Zhang",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Hailong Tian",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Dezhang Huang",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Xianbing Meng",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Wenqiang Guo",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Chaochao Wang",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Xin Yin",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Hongying Zhang",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Bin Jiang",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Zheng He",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            },
            {
                "name": "Zhigang Wang",
                "org": "Department of Neurosurgery, Qilu Hospital, Shandong University, Qingdao, China"
            }
        ],
        "venue": "BioMed Research International",
        "year": 2017
    },
    "2GCMHTjY": {
        "id": "2GCMHTjY",
        "title": "Follow-up Results and Clinical Significance of Magnetic Resonance Spectroscopy Combined with Fluorescence Microscopy in Resection of High Grade Supra-tentoria Gliomas.",
        "abstract": "Objective To investigate the clinical effectiveness of magnetic resonance spectroscopy (MRS) combined with sodium fluorescein(FL) in the treatment of high grade gliomas(HGG). Methods From August 2013 to 2015 November,the clinical data of 72 supratentorial HGG(WHO grade \u2162-\u2163) patients who had received surgical treatment in our hospital were retrospectively studied,among whom 43 cases received MRS combined with intra-perative FL navigation(observation group),and 29 cases only received conventional surgery(control group). Post-operative radiotherapy and chemotherapy were applied for more than 3 months. Routine enhanced MRI were performed 24-48 hours after the operation to investigate the extent of tumor resection. Six months after the operation,the quality of life of patients was evaluated by using the Karnofsky score,and 1-year postoperative survival rate and progression-free survival(PFS) were observed. Results Postoperative MRI showed that the rate of gross total resection(GTR) in observation group was significantly higher than that in control group(72.09%vs.51.72%;\u03c7=23.88,P=0.001),and the GTR rate of WHO grade \u2163 tumors was significantly higher than that of WHO grade \u2162 tumors in observation group(92.86% vs.62.07%;\u03c7=6.06,P=0.042). The postoperative Karnofsky score in the observation group was significantly higher than that in control group(\u03bc=2.34,P=0.021). The mean time of follow-up was(16.4\u00b12.4) months(8-21 months) and there was no statistical significant difference between observation group and control group in 1-year survival rate(74.07% vs.77.50%;\u03c7=4.90,P=0.165) and PFS [(13.2\u00b11.2) months vs.(12.7\u00b12.0) months;\u03c7=7.26,P=0.067]. In observation group,the PFS of WHO grade \u2163 patients was significantly higher than that in control group [(14.2\u00b10.3) months vs.(10.0\u00b11.1) months;\u03c7=11.03,P=0.031]. There was also no statistical significant difference between WHO grade \u2163 tumors in two groups in terms of 1-year survival rate(71.43% vs.72.54%;\u03c7=5.33,P=0.089),and there was no statistical significant difference between WHO grade \u2162 tumors in two groups in 1-year survival rate(75.86% vs. 72.22%;\u03c7=3.78,P=0.250) and in PFS [(13.7\u00b11.4) months vs.(12.4\u00b10.8) months;\u03c7=4.85,P=0.083]. Conclusions MRS combined with intraoperative FL navigation technology can improve the resection rate and improve survival quality of patients,and there is no evidence that MRS combined with intraoperative FL navigation prolong the overall survival of patients with high-grade gliomas. Different outcome may be found with longer follow-up and increased simple size.",
        "keywords": "",
        "authors": [
            {
                "name": "Hai-Long Tian",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Yu-Liang Zu",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Wei He",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Ning-Ning Zhang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Yi-Hua Wang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Zhen-Tao Guo",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Chao-Chao Wang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Bin Jiang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Xin Yin",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            },
            {
                "name": "Zhi-Gang Wang",
                "org": "Department of Neurosurgery,Qilu Hospital,Shandong University,Qingdao,Shandong 266000,China."
            }
        ],
        "venue": "Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae",
        "year": 2017
    },
    "cn9lhior": {
        "id": "cn9lhior",
        "title": "PCR-RFLP polymorphism of alpha-amylase gene and its association with growth traits of Litopenaeus vannamei",
        "abstract": "The polymorphism of the alpha-amylase(AMY) gene was analyzed by PCR-RFLP method in 379 Litopenaeus vannamei,and association analyses were carried out to evaluate the effects of genotypes of the candidate genes on growth traits in Litopenaeus vannamei.The results showed that both the products amplified by primer AMY-5 and AMY-6 displayed polymorphisms,and there were three genotypes(CC,TT and CT) for AMY-5 and three genotypes(AA,AB and BB) for AMY-6 respectively.The results indicated that there was one single nucleotide mutation(C\u2192T) in the exon5(123 bp) and one single nucleotide mutation(C\u2192T) in the exon6(81 bp) of the alpha-amylase gene.The two mutations did not cause any amino acid changes and were silence mutations.Least square was applied to analyze the correlation of different genotypes and the growth traits.The CC and CT genotypes showed significant differences in body mass,body length,carapace length,carapace width,first abdominal segment length and the last abdominal segment length compared with the genotype TT(P<0.05).The AA and BB genotypes showed significant differences in body length,first abdominal segment length and the last abdominal segment length compared with the genotype AB(P<0.05).The AA genotype showed significant differences in body mass,carapace length,carapace width compared with the genotype AB(P<0.05).It implied that the AMY gene could have a major effect on the growth traits of Litopenaeus vannamei,and could be used as the gene that significantly affect the growth traits in Litopenaeus vannamei,and these molecular genetic markers may be applied for Litopenaeus vannamei breeding.",
        "keywords": [
            "growth traits",
            "Litopenaeus vannamei",
            "PCR-RFLP",
            "alpha-amylase gene"
        ],
        "authors": [
            {
                "name": "XIN Jing-jing",
                "org": "College of Animal Science and Technology,Northwest A&F University,Shaanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "College of Animal Science and Technology,Northwest A&F University,Shaanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "LI Xi-lian",
                "org": "College of Animal Science and Technology,Northwest A&F University,Shaanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "WANG Xian-zong",
                "org": "College of Animal Science and Technology,Northwest A&F University,Shaanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Company Limited,Sanya ,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Acta Oceanologica Sinica",
        "year": 2011
    },
    "lRN00VbX": {
        "id": "lRN00VbX",
        "title": "Selection for growth performance of tank-reared Pacific white shrimp, Litopenaeus vannamei",
        "abstract": "Seven growth-related traits were measured to assess the selection response and genetic parameters of the growth of Pacific white shrimp, Litopenaeus vannamei, which had been domesticated in tanks for more than four generations. Phenotypic and genetic parameters were evaluated and fitted to an animal model. Realized response was measured from the difference between the mean growth rates of selected and control families. Realized heritability was determined from the ratio of the selection responses and selection differentials. The animal model heritability estimate over generations was 0.44\u00b10.09 for body weight (BW), and ranged from 0.21\u00b10.08 to 0.37\u00b10.06 for size traits. Genetic correlations of phenotypic traits were more variable (0.51\u20130.97), although correlations among various traits were high (>0.83). Across generations, BW and size traits increased, while selection response and heritability gradually decreased. Selection responses were 12.28%\u201323.35% for harvest weight and 3.58%\u201313.53% for size traits. Heritability estimates ranged from 0.34\u00b10.09 to 0.48\u00b10.15 for harvest weight and 0.17\u00b10.01\u20130.38\u00b10.11 for size traits. All phenotypic and genetic parameters differed between various treatments. To conclude, the results demonstrated a potential for mass selection of growth traits in L. vannamei. A breeding scheme could use this information to integrate the effectiveness constituent traits into an index to achieve genetic progress.",
        "keywords": [
            "response to selection",
            "growth performance",
            "quantitative genetics",
            "realized heritability",
            "Pacific white shrimp"
        ],
        "authors": [
            {
                "name": "LIU Xiaolin",
                "org": " College of Animal Science and Technology, Northwest A & F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling , China"
            },
            {
                "name": "HUANG Hao",
                "org": " Hainan Guangtai Ocean Breeding Company Limited, Haikou , China"
            },
            {
                "name": "XIANG Jianhai",
                "org": " Experimental Marine Biology Laboratory, Institute of Oceanology, Chinese Academy of Sciences, Qingdao , China"
            }
        ],
        "venue": "\u4e2d\u56fd\u6d77\u6d0b\u6e56\u6cbc\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2013
    },
    "I2AjXp9E": {
        "id": "I2AjXp9E",
        "title": "Selective breeding and pedigree foundation of Litopenaeus vannamei",
        "abstract": "Mass selection and pedigree selective breeding were performed using periodic and family selection methods in 14 different populations from three different origins.206 pedigrees were set up in Litopenaeus vannamei,120 pedigrees,which were grow slowly and with less anti-stress ability,were eliminated through selection according to different biological criteria.The growth and rate of morphological abnormality of 80 pedigrees,which were cultured to commercial stage,were statisticated.The results demonstrated that there are significant differences in growth rate mortality and abnormal rate between different pedigrees although they were cultured in the same or similar environment.The weights of 150 days' shrimp in all the pedigrees were in normal distribution.40 pedigrees,which have a better biological phenotype,were selected for the next generation production.Combined with the theory and production in selective breeding at home and abroad,population selection and individual selection in Litopenaeus vannamei were performed by creationary,statistic and comparison analysis on growing condition in 80 selectived populations were dealt,the rate of morphological abnormality was taken as one of selection guide lines first time,population selection system in Litopenaeus vannamei was set preliminarily,a better technical stage for production and theory study was set.And it maybe provide better thoroughbred in aquaculture breeding of prawn in the future.",
        "keywords": [
            "pedigrees",
            "selective breeding",
            "Litopenaeus vannamei"
        ],
        "authors": [
            {
                "name": "CHEN Mao",
                "org": "SunYat-sen University,Guangzhou ,China;Hainan Nanjiang Marine Biotechnique Company Limited.Sanya ,China"
            },
            {
                "name": "WU Chang-gong",
                "org": "Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": "Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Hainan Nanjiang Marine Biotechnique Company Limited.Sanya ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "University of Agriculture and Forestry,Yangling ,China"
            },
            {
                "name": "LIU Cui-hong",
                "org": "SunYat-sen University,Guangzhou ,China"
            },
            {
                "name": "HE Jian-guo",
                "org": "SunYat-sen University,Guangzhou ,China"
            },
            {
                "name": "SUN Cheng-bo",
                "org": "Zhanjiang Ocean University,Zhanjiang ,China"
            }
        ],
        "venue": "Marine Sciences",
        "year": 2008
    },
    "tfmfMmNj": {
        "id": "tfmfMmNj",
        "title": "Screening and polymorphism of EST-microsatellite markers in Litopenaeus vannamei",
        "abstract": "Fourteen microsatellite DNA universal markers derived from Belgian wild shrimps expressed sequences tags(ESTs) were selected and evaluated.Stable banding pattern was shown by 7 EST-SSRs,and five of(CNM-MG 345,CNM-MG 390,CNM-MG 437,CNM-MG 444,CNM-MG 487) them were identified as the polymorphism EST-SSR,and subsequently used for genotyping of 240 cultured adult white shrimps sampled from Hainan Province.The characterization results,which revealed 2.400 0\u00b10.547 7 alleles per locus,observed and expected heterozygosity levels ranged from 0.279 2 to 0.820 8 and from 0.377 9 to 0.601 1 respectively,showed the moderate polymorphisms at these loci.In addition,genetic difference between the Belgian wild population and Hainan cultured population was firstly found,which might caused by geographic isolation and selective breeding over the years.This study set The foundation for population genetics studies,function gene analysis and selective breeding was set in Hainan cultured Litopenaeus vannamei.",
        "keywords": [
            "EST-SSR",
            "Litopenaeus vannamei",
            "genetic diversity"
        ],
        "authors": [
            {
                "name": "ZHANG Qiong",
                "org": "Key Laboratory of Shaanxi Province for Molecular Biology for Agriculture,College of Animal Sciences and Technology,Northwest Agricalture & Forest University,Yangling ,China"
            },
            {
                "name": "LI Xi-lian",
                "org": "Key Laboratory of Shaanxi Province for Molecular Biology for Agriculture,College of Animal Sciences and Technology,Northwest Agricalture & Forest University,Yangling ,China"
            },
            {
                "name": "XUE Shu-wen",
                "org": "Key Laboratory of Shaanxi Province for Molecular Biology for Agriculture,College of Animal Sciences and Technology,Northwest Agricalture & Forest University,Yangling ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "Key Laboratory of Shaanxi Province for Molecular Biology for Agriculture,College of Animal Sciences and Technology,Northwest Agricalture & Forest University,Yangling ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Company Limited,Sanya ,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": "Open of Laboratory Experimental Marine Biology,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Acta Oceanologica Sinica",
        "year": 2011
    },
    "kiORrXPR": {
        "id": "kiORrXPR",
        "title": "Principal component and discriminant analyses of traits of Litopenaeus vannamei at different ages",
        "abstract": "In order to research on the rule of the relative growth of traits of Litopenaeus vannamei and judging the age matching with the size of L.vannamei missing the best growing season,the data acquired by measuring the total length(X1),body length(X2),first abdominal segment depth(X3),third abdominal segment depth(X4),first abdominal segment width(X5),carapace length(X6)and body weight(Y)of Penaeus vannamei at different ages in Banqiao Village of Dongfang City,Hanan Province were analyzed by principal component and discriminant analysis.Result shows that the correlation between any two traits of L.vannamei is significant(P<0.01)at all tested ages.,among which those between the total length(X1)and body length(X2)are relatively larger and those between body weight(Y)and morphometric attributes are relatively smaller.The principal components of L.vannamei at different ages are different.For example,the first principal component of L.vannamei at from one month of age to two months is length factor,the second principal component is width factor and the third principal component is depth factor.Also,for L.vannamei at three months of age,its first principal component is the same as that at from one month of age to two months,but its second principal component is depth factor and its third principal component is body weight factor.Finally,the first principal component of L.vannamei at from four months of age to six months is body weight factor,the second principal component is depth factor and the third principal component is width factor.The results of principal component analysis reflect that the growth of morphometric attributes of L.vannamei at from one month of age to three months takes priority compared with that of body weight,but the growth of body weight of L.vannamei at from three months of age to six months is given priority to compared with that of morphometric attributes.The month age closely related to the size of L.vannamei which has missed the best growing period can be deduced by employing the discriminant equations mentioned in this paper and the results of the discriminant analysis demonstrate that the overall accuracy is 98.98% and those of L.vannamei at two months of age to four months all reach 100%.",
        "keywords": [
            "principal component analysis",
            "discriminant analysis",
            "Litopenaeus vannamei",
            "correlation analysis"
        ],
        "authors": [
            {
                "name": "HE Tong",
                "org": " College of Animal Science and Technology,Northwest A and F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "LIU Xiao-Lin",
                "org": " College of Animal Science and Technology,Northwest A and F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "YANG Chang-Ming",
                "org": " College of Animal Science and Technology,Northwest A and F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "HUANG Hao",
                "org": " Nanjiang Marine Biotechnology Company Limited,Sanya,Hainan ,China"
            },
            {
                "name": "XIANG Jian-Hai",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Acta Ecologica Sinica",
        "year": 2009
    },
    "8tG9kExi": {
        "id": "8tG9kExi",
        "title": "Kinship analysis and genetic variation monitoring in Litopenaeus vannamei breeding program using microsatellite DNA markers",
        "abstract": "Genotype segregation of parents livestocks(G 0 generation)and their offspring(G 1 generation)of 6 Litopenaeus vannamei families was analyzed on basis of 7 microsatellite DNA markers.In addition,heterogeneity analysis for pairwise comparisons of expected heterozygosities(H e) of all loci between G 0 and G 1 was carried out and genetic differentiation through F-statistics at each locus in G 1 population was expected to monitor genetic variation in Litopenaeus vannamei breeding.The results showed that 44 alleles were detected in total across 7 loci assayed,mean number per locus,mean expected heterozygosity and mean polymorphism information content of G 0 generation were 6.14,0.786 and 0.709 respectively,and those of G 1 generation were 6.27,0.733 and 0.695 respectively.The combined exclusion probability of 7 microsatellite markers arrived at 0.99 and could seperate all 6 families with known parent.Heterogeneity analysis for pairwise comparisons of expected H e of all loci between G 0 and G 1 indicated that H e of G 0 was significantly higher than G 1(P <0.01).F ST of G 1 per locus ranged from 0.270 3 to 0.465 4 and average was 0.358 4 which meant that genetic differentiation in its sub-population was high.The UPGMA analysis based on six families genetic distances showed all individuals of G 1 generation could be classified into 4 categories.Similarly to families C and D,families A and B sharing father had high similarity coefficient and clustered together,family E and F were assigned into another group respectively.",
        "keywords": [
            "microsatellite",
            "kinship analysis",
            "litopenaeus vannamei",
            "genetic monitoring",
            "heterozygosity",
            "alleles",
            "heterogeneity",
            "genotypes",
            "genetic markers",
            "genetic variation",
            "microsatellites",
            "genetic distance",
            "kinship"
        ],
        "authors": [
            {
                "name": "WANG Xia",
                "org": "College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling ,China;Insititute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling ,China"
            },
            {
                "name": "ZHANG Ji-quan",
                "org": "Insititute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            },
            {
                "name": "ZHANG Cheng-song",
                "org": "Insititute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Company Limited,Sanya ,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": "Insititute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Journal of Fisheries of China",
        "year": 2009
    },
    "3tKCoqRx": {
        "id": "3tKCoqRx",
        "title": "Application of Simple Sequence Repeats Derived from Expression Sequence Tags (EST-SSRs) in Aquatic Animal Genomics",
        "abstract": "",
        "keywords": [
            "EST-SSR",
            "molecular marker",
            "aquatic animal",
            "genetic breeding"
        ],
        "authors": [
            {
                "name": "ZHANG Qiong",
                "org": "College of Animal Sciences and Technology,Northwest A & F University,Shanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "College of Animal Sciences and Technology,Northwest A & F University,Shanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "LI Xi-lian",
                "org": "College of Animal Sciences and Technology,Northwest A & F University,Shanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "XUE Shu-wen",
                "org": "College of Animal Sciences and Technology,Northwest A & F University,Shanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "XIN Jing-jing",
                "org": "College of Animal Sciences and Technology,Northwest A & F University,Shanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Company Limited,Sanya ,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Fisheries Science",
        "year": 2010
    },
    "axLQzuzw": {
        "id": "axLQzuzw",
        "title": "AFLP analysis of genetic diversity of shrimp Litopenaeus vannamei",
        "abstract": "\u3010Objective\u3011The study was done to evaluate the genetic diversity of cultured Litopenaeus vannamei in order to provide a technical basis for inheritance breeding work.\u3010Method\u3011Amplified fragment length polymorphism(AFLP)technique has been used to analyze the genetic variation among a total of 350 indiciduals representing 35 families of L.vannamei.The number of polymorphic loci was counted.Popgene Version 1.31,Arlequin Version 3.1 and Mega 3.1 were taken to calculate the genetic diversity index of the families of Shannon's genetic diversity index and the genetic differentiation index of Fst.Cluster analysis was performed between 350 individuals of 35 families using UPGMA method based the Nei's distance.\u3010Result\u3011Ten pairs of selective primers produced 162 polymorphic markers out of 312 bands amplified.The percentage of polymorphic loci was 51.92%.The percentage of polymorphic loci and Shannon index among families was between 12.50%-32.69% and 0.068 3-0.181 7. AMOVA(Analysis of molecular variance) showed that 63.62% of genetic variation resided within families,while 36.38% of genetic variation resided between families,representing the genetic differentiation index of Fst 0.363 8.Via Fst,the Nm 0.937 2.\u3010Conclusion\u3011The Litopenaeus vannamei for examination was on a high level of genetic diversity,and had some indeed selective capacity.Fst showed that the most genetic variation resided within families,Nm showed that limited gene flowing was the main cause of the genetic variation,which indicated the whole 35 families formed a relatively independent system during breeding.The cluster analysis declined the evolution relationship among families,which could provide a basis for the future breeding work.",
        "keywords": [
            "aflp",
            "litopenaeus vannamei",
            "genetic diversity",
            "genes",
            "population genetics",
            "animal breeding",
            "gene flow",
            "aquatic animals",
            "genetic variation",
            "amplified fragment length polymorphism"
        ],
        "authors": [
            {
                "name": "XUE Shu-wen",
                "org": " Shaanxi Key Laboratory of Molecular Biology for Agriculture,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": " Shaanxi Key Laboratory of Molecular Biology for Agriculture,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "LI Xi-lian",
                "org": " Shaanxi Key Laboratory of Molecular Biology for Agriculture,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "ZHANG Qiong",
                "org": " Shaanxi Key Laboratory of Molecular Biology for Agriculture,College of Animal Science and Technology,Northwest A&F University,Yangling,Shaanxi ,China"
            },
            {
                "name": "HUANG Hao",
                "org": " Nanjiang Marine Biotechnology Company Limited,Sanya,Hainan,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": " Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao,Shandong,China"
            }
        ],
        "venue": "Journal of Northwest A & F University(Natural Science Edition)",
        "year": 2010
    },
    "bTXDYp1u": {
        "id": "bTXDYp1u",
        "title": "Stepwise Regression Analysis of Morphometric Attributes on Body Weight of Penaeus vannamei",
        "abstract": "The effects of eight morphometric attributes on body weight of Penaeus vannamei were analyzed on the base of the data collected from 900 five-month-old Penaeus vannamei in Banqiao village of Dongfang city,Hainan province.The total length(x1),body length(x2),first abdominal segment depth(x3),third abdominal segment depth(x4),first abdominal segment width(x5),carapace length(x6),carapace width(x7),carapace depth(x8) and body weight(y) were measured.Correlation coefficients among all attributes were calculated.Also,path coefficients and determination coefficients were calculated in path analysis where eight morphometric attributes(x1-x8) were regarded as independent variables and body weight(y) was used as a dependent variable.The results indicate that all correlation coefficients between morphometric attributes and body weight all achieve very significant difference(P<0.01) level.The path coefficient analysis reveals a truthful relationship between independent variables and the dependent variable.The path coefficients of total length(x1),body length(x2),first abdominal segment depth(x3),first abdominal segment width(x5),carapace width(x7),and carapace depth(x8) to body weight all reaches significance level.These attributes are quite indicative of determining body weight,among which total length(x1) weighs the most(0.328 4**) to body weight,so it is a key effective factor,while the direct effect of first abdominal segment depth(x3) on body weight is least(0.049 2*).Although the correlation coefficient between third abdominal segment depth(x4) and body weight is rather large(0.735 7**),its direct influence on body weight is quite small just like carapace length(x6).Therefore,third abdominal segment depth(x4) and carapace length(x6) affect body weight mainly by their relationship with other attributes,so they are insignificant factors influencing body weigh and eliminated.Similar results appear by calculating determination coefficients and path analysis.Furthermore,the multiple-correlation coefficient between the chosen attributes and body weight reaches as high as R2=0.944 9.All above illustrate that the main attributes determining body weight have already been discovered.The stepwise regression analysis establishes the multiple regression equation on the overall effect of total length(x1),body length(x2),first abdominal segment depth(x3),first abdominal segment width(x5),carapace width(x7) and carapace depth(x8) on body weight(y).The regression intercept and partial regression coefficients of the equation are 1.043,0.547,0.969,2.279,6.118 and 2.797.",
        "keywords": [
            "Path analysis",
            "Stepwise regression analysis",
            "Penaeus vannamei",
            "Correlation analysis",
            "Morphometric attribute"
        ],
        "authors": [
            {
                "name": "YANG Changming",
                "org": "College of Animal Science and Technology,Northwest A&F University,Yangling Shaanxi ,China"
            },
            {
                "name": "HE Tong",
                "org": "College of Animal Science and Technology,Northwest A&F University,Yangling Shaanxi ,China"
            },
            {
                "name": "LIU Xiaolin",
                "org": "College of Animal Science and Technology,Northwest A&F University,Yangling Shaanxi ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Company Limited,Sanya Hainan ,China"
            },
            {
                "name": "XIANG Jianhai",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao Shandong ,China"
            }
        ],
        "venue": "Acta Agriculturae Boreali-Occidentalis Sinica",
        "year": 2011
    },
    "8hqeoYtq": {
        "id": "8hqeoYtq",
        "title": "Mathematical analysis of the factors affecting the net weight of Litopenaeus vannamei",
        "abstract": "The effects of morphometric attributes on net weight for Litopenaeus vannamei were analyzed.Data for this study were collected from five-month-old 1 200 L.vannamei in Banqiao Village of Dongfang City,Hainan Province.The body weight except for head(X1),whole body length(X2),body length(X3),fist first abdominal segment depth(X4),third abdominal segment depth(X5),first abdominal segment width(X6),carapace length(X7) and net weight(Y) were measured.The correlation coefficients among the attributes were calculated. Path coefficient(pi),determination coefficients(di) and correlation index(R2) were calculated in path analysis.The results showed that six correlation coefficients between each morphometric attribute and the weight achieved very significant difference(P<0.01) levels.The path coefficient analysis revealed a truthful relationship between the independent variables and the dependent variable.Judging from the result of high correlation index(R2=0.958),the main variables(X1,X2,X7) have been selected.The multiple regression equation of body weight except for head,whole body length,carapace length to the net weight is obtained to estimate the net weight.This paper provides a theoretical tool to measure breeding shrimps in aquaculture.",
        "keywords": [
            "Litopenaeus vannamei",
            "correlation analysis",
            "morphometric attribute"
        ],
        "authors": [
            {
                "name": "LI Gang",
                "org": "College of Animal Science and Technology,Northwest Agriculture Forest University,Yangling,,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "College of Animal Science and Technology,Northwest Agriculture Forest University,Yangling,,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Company Limited,Sanya ,China"
            },
            {
                "name": "CUI Zhao-xia",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,the Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Marine Sciences",
        "year": 2007
    },
    "V5mmw0FC": {
        "id": "V5mmw0FC",
        "title": "A Review: Advances in Genetics and Breeding in Shrimp",
        "abstract": "",
        "keywords": [
            "genetics and breeding",
            "shrimp",
            "advance"
        ],
        "authors": [
            {
                "name": "LI Gang",
                "org": "College of Animal Science and Technology,Northwest Agriculture&Forest University,Yangling ,China"
            },
            {
                "name": "LIU Xiao-lin",
                "org": "College of Animal Science and Technology,Northwest Agriculture&Forest University,Yangling ,China"
            },
            {
                "name": "HUANG Hao",
                "org": "Nanjiang Marine Biotechnology Limited Company,Sanya ,China"
            },
            {
                "name": "CUI Zhao-xia",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            },
            {
                "name": "XIANG Jian-hai",
                "org": "Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "Fisheries Science",
        "year": 2007
    },
    "BKATvO26": {
        "id": "BKATvO26",
        "title": "ZResponse to selection,heritability and genetic correlations between body weight and body size in Pacific white shrimp,Litopenaeus vannamei",
        "abstract": "To quantify the response to selection,heritability and genetic correlations between weight and size of Litopenaeus vannamei,the body weight (BW),total length (TL),body length (BL),first abdominal segment depth (FASD),third abdominal segment depth (TASD),first abdominal segment width (FASW),and partial carapace length (PCL) of 5-month-old parents and of offspring were measured by calculating seven body measurings of offspring produced by a nested mating design.Seventeen half-sib families and 42 full-sib families ofL.vannamei were produced using artificial fertilization from 2-4 dams by each sire,and measured at around five months post-metamorphosis.The results show that heritabilities among various traits were high:0.515\u58eb0.030 for body weight and 0.394\u58eb0.030 for total length.After one generation of selection,the selection response was 10.70% for offspring growth.In the 5\"' month,the realized heritability for weight was 0.296 for the offspring generation.Genetic correlations between body weight and body size were highly variable.The results indicate that external morphological parameters can be applied during breeder selection for enhancing the growth without sacrificing animals for determining the body size and breed ability;and selective breeding can be improved significantly,simultaneously with increased production.",
        "keywords": [
            "selection response",
            "genetic correlation",
            "Litopenaeus vannamei",
            "heritability",
            "growth"
        ],
        "authors": [
            {
                "name": "LIU Xiaolin",
                "org": " College of Animal Science and Technology,Northwest A & F University,Shaanxi Key Laboratory of Molecular Biology for Agriculture,Yangling ,China"
            },
            {
                "name": "HUANG Hao",
                "org": " Hainan Guangtai Ocean Breeding Company Limited,Haikou ,China"
            },
            {
                "name": "XIANG Jianhai",
                "org": " Experimental Marine Biology Laboratory,Institute of Oceanology,Chinese Academy of Sciences,Qingdao ,China"
            }
        ],
        "venue": "\u4e2d\u56fd\u6d77\u6d0b\u6e56\u6cbc\u5b66\u62a5(\u82f1\u6587\u7248)",
        "year": 2012
    },
    "mWnZV4eX": {
        "id": "mWnZV4eX",
        "title": "Molecularly imprinted polymer hydrogel as 5-FU controlled release carrier",
        "abstract": "5-fluorouracil as template drug,2-hydroxyethylmetacrylate as backbone monomer, methacrylic acid as functional monomer,ethyleneglycol dimethacrylate as crosslinker and 2,2'-azoisobutyronitrile as initiator were used to synthesize molecularly imprinted polymer hydrogels, which were characterized with SEM,FT-IR,and DSC.The results indicated that the hydrogel surface was poreless and smooth,and in hydrogels the template drug of 5-fluorouracil interacted with monomers into solid solutions through hydrogen bonds and unreacted monomers no longer existed. Swelling tests of imprinted hydrogels showed that swelling capacity increased with the amount of 5-fluorouracil during synthesis,and swelling ability as well as swelling speed increased with increasing pH in the system.Meanwhile tests of drug loading capacity showed that the imprinted hydrogels both performed better than the non-imprinted one and MIP(functional monomer-template molar ratio 8\u22361) performed better than MIP(functional monomer-template molar ratio 4\u22361) with loading capacity amounting to 0.0914 mg/g.Tests on drug release behavior of the hydrogels in simulated biological fluids indicated that all the imprinted hydrogels controlled drug release better than the non-imprinting one,and hydrogels with functional monomer-template molar ratio 8\u22361 exhibited the best to control the 5-fluorouracil release process.Meanwhile,release media with a high pH was unfavorable to controlled release of the imprinted hydrogel.",
        "keywords": [
            "controlled release of drug",
            "carrier",
            "hydrogel",
            "molecular imprinting",
            "5-fluorouracil"
        ],
        "authors": [
            {
                "name": "KAN Wentao",
                "org": "Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang ,Sichuan, China"
            },
            {
                "name": "LI Xin",
                "org": "Department of Chemistry,Harbin Institute of Technology,Harbin ,Heilongjiang,China"
            },
            {
                "name": "LUO Shunzhong",
                "org": "Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang ,Sichuan, China"
            },
            {
                "name": "HU Rui",
                "org": "Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang ,Sichuan, China"
            }
        ],
        "venue": "Chemical Industry and Engineering Progress",
        "year": 2013
    },
    "xEhusup6": {
        "id": "xEhusup6",
        "title": "The Study on Release Mechanism of Hydrogel Piece as Drug Carrier",
        "abstract": "The mechanism of drug release process from dry hydrogel pieces containing 5-fluorouracil in simulated body fluid has been explained.Conclusions have been drawn through analysis on mathematical rule which the diffusion of drug in hydrogels follows.When drug release is controlled by hydrogel relaxation,and the movement of solvent is the key factor,drug may release from the hydrogels at constant rate.An experiment has been performed to test the conclusions,whose outcomes are consistent with the conclusions drawn from the mathematical analysis.",
        "keywords": [
            "mathematical analysis",
            "carrier",
            "hydrogel",
            "5-fluorouracil",
            "drug release mechanism"
        ],
        "authors": [
            {
                "name": "KAN Wentao",
                "org": " Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang "
            },
            {
                "name": "LI Xin",
                "org": " Department of Chemistry,Harbin Institute of Technology,Harbin "
            },
            {
                "name": "LUO Shunzhong",
                "org": " Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang "
            },
            {
                "name": "HU Rui",
                "org": " Institute of Nuclear Physics and Chemistry,China Academy of Engineering Physics,Mianyang "
            }
        ],
        "venue": "Materials Review",
        "year": 2013
    },
    "vikE7lRJ": {
        "id": "vikE7lRJ",
        "title": "Short Term Follow-up for Coronary Artery Bypass Grafting Combined with Valve Replacement Surgery",
        "authors": [
            {
                "name": "Xu Dong",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Liu Yanhui",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Shang Xuebin",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Li Xuefeng",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Wang Shouyu",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Liu Fei",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            },
            {
                "name": "Li Hongli",
                "org": "Department of Cardiovascular Surgery,Xuanwu Hospital,Capital University of Medical Sciences"
            }
        ],
        "venue": "journal of capital university of medical sciences",
        "keywords": [
            "coronary artery disease",
            "coronary artery bypass grafting",
            "rheumatic heart disease",
            "valve replacement"
        ],
        "year": 2006
    },
    "J1TOUtHI": {
        "id": "J1TOUtHI",
        "title": "Effects of postoperative nesiritide in patients with left ventricular dysfunction undergoing coronary artery bypass",
        "authors": [
            {
                "name": "ZHANG Ke-feng",
                "org": "Heart Center, Xuanwu Hospital, CMU, the Capital Medical University, Beijing "
            },
            {
                "name": "XU Dong",
                "org": "Heart Center, Xuanwu Hospital, CMU, the Capital Medical University, Beijing "
            },
            {
                "name": "SHANG Xue-bin",
                "org": "Heart Center, Xuanwu Hospital, CMU, the Capital Medical University, Beijing "
            }
        ],
        "venue": "beijing medical journal",
        "keywords": [
            "Recombinant human brain natriuretic peptide Myocardial infarction Coronary artey bypass grafting"
        ],
        "year": 2012
    },
    "npEZQGxs": {
        "id": "npEZQGxs",
        "title": "Study on efficacy and safety of diltiazem plus nitroglycerin for angina pectoris of older three-vessel disease",
        "authors": [
            {
                "name": "XIA Jing-gang",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of hospital pharmacy",
        "keywords": [
            "nitroglycerin",
            "diltiazem",
            "three-vessel disease",
            "unstable angina pectoris"
        ],
        "year": 2009
    },
    "yaFXm1Bw": {
        "id": "yaFXm1Bw",
        "title": "Video-assisted minimal invasive surgical procedure for atrial fibrillation:a report of 6 cases",
        "authors": [
            {
                "name": "ZHANG Ke-feng",
                "org": "Heart Center,Xuanwu Hospital,Capital Medical University,Beijing "
            },
            {
                "name": "XU Dong",
                "org": "Heart Center,Xuanwu Hospital,Capital Medical University,Beijing "
            },
            {
                "name": "SHANG Xue-bin",
                "org": "Heart Center,Xuanwu Hospital,Capital Medical University,Beijing "
            }
        ],
        "venue": "beijing medical journal",
        "keywords": [
            "Atrial fibrillation Surgical procedure Minimally"
        ],
        "year": 2012
    },
    "aWzdXfAK": {
        "id": "aWzdXfAK",
        "title": "Investigation of Improving the Communication Ability of Standardized Training Resident Physicians in Cardiology Intensive Care Unit",
        "authors": [
            {
                "name": "XIA Jing-gang"
            },
            {
                "name": "QU Yang"
            },
            {
                "name": "YIN Chun-lin"
            },
            {
                "name": "XU Dong"
            },
            {
                "name": "XU Ji"
            },
            {
                "name": "HU Shao-dong"
            }
        ],
        "venue": "progress in modern biomedicine",
        "keywords": [
            "Standardized training",
            "Residency",
            "Cardiology intensive care unit",
            "Doctor-patient communication"
        ],
        "year": 2013
    },
    "4DmmQoPJ": {
        "id": "4DmmQoPJ",
        "title": "Preoperative rosuvastatin protects patients with coronary artery disease undergoing noncardiac surgery.",
        "authors": [
            {
                "name": "Xia Jinggang",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing, PR China."
            },
            {
                "name": "Qu Yang"
            },
            {
                "name": "Yin Chunlin"
            },
            {
                "name": "Xu Dong"
            }
        ],
        "venue": "cardiology",
        "keywords": [],
        "year": 2015
    },
    "qSfd6oLw": {
        "id": "qSfd6oLw",
        "title": "Application of Endoscopic Great Saphenous Vein Harvesting during Coronary Artery Bypass Grafting",
        "authors": [
            {
                "name": "LI Hong-li",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "XU Dong",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "SHANG Xue-bin",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "LIU Yan-hui",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "LIU Fei",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "ZHANG Ke-feng",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "YAO Qing",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            }
        ],
        "venue": "journal of capital medical university",
        "keywords": [
            "coronary artery bypass grafting",
            "endoscope",
            "great saphenous vein",
            "histology"
        ],
        "year": 2009
    },
    "RktgnM3m": {
        "id": "RktgnM3m",
        "title": "Clinical diagnosis and differential diagnosis of constrictive pericarditis:a two-case analysis",
        "authors": [
            {
                "name": "YIN Chun-lin",
                "org": ".Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": ".Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WEI Jia-ping",
                "org": ".Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "FAN Zhen-xing",
                "org": ".Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XIA Jing-gang",
                "org": ".Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Jia-rui",
                "org": ".Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of practical internal medicine",
        "keywords": [
            "constrictive pericarditis",
            "square-root sign",
            "restrictive cardiomyopathy",
            "right ventricular failure"
        ],
        "year": 2011
    },
    "PI6I1V5u": {
        "id": "PI6I1V5u",
        "title": "Risk factors of asymptomatic pericardial effusion after radiofrequency ablation in atrial fibrillation",
        "authors": [
            {
                "name": "KONG Qiang",
                "org": "Department of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing,,China"
            },
            {
                "name": "SHI Lisheng",
                "org": "Department of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing,,China"
            },
            {
                "name": "YU Ronghui",
                "org": "Department of Cardiology,Anzhen Hospital Affiliated to Capital Medical University"
            },
            {
                "name": "LONG Deyong",
                "org": "Department of Cardiology,Anzhen Hospital Affiliated to Capital Medical University"
            },
            {
                "name": "CHEN Yujia",
                "org": "Department of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing,,China"
            },
            {
                "name": "XU Dong",
                "org": "Department of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing,,China"
            }
        ],
        "venue": "journal of clinical cardiology",
        "keywords": [
            "atrial fibrillation",
            "radiofrequency ablation",
            "asymptomatic pericardial effusion",
            "risk factors"
        ],
        "year": 2012
    },
    "5hXUjpZs": {
        "id": "5hXUjpZs",
        "title": "The Clinical Significance of High Sensitive C-reactive Protein in Patients with Acute Coronary Syndrome",
        "authors": [
            {
                "name": "YANG Jing",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University"
            },
            {
                "name": "HUA Qi",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University"
            },
            {
                "name": "XU Dong",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University"
            },
            {
                "name": "TAN Jing",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University"
            }
        ],
        "venue": "journal of capital medical university",
        "keywords": [
            "acute coronary syndrome",
            "high sensitive c-reactive protein",
            "unstable angina",
            "acute myocardial infarction"
        ],
        "year": 2009
    },
    "prNQ8LcV": {
        "id": "prNQ8LcV",
        "title": "Initial application and learning curve of endoscopic saphenous vein harvesting during coronary artery bypass grafting",
        "authors": [
            {
                "name": "XU Dong",
                "org": ",et alHeart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Hongli",
                "org": ",et alHeart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHANG Kefeng",
                "org": ",et alHeart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of multiple organ diseases in the elderly",
        "keywords": [
            "saphenous vein",
            "off pump",
            "endoscope",
            "coronary artery bypass",
            "learning curve"
        ],
        "year": 2009
    },
    "ftZWQiSk": {
        "id": "ftZWQiSk",
        "title": "The diagnosis and surgical treatment experience in cardiac mass: a report of 26 cases",
        "authors": [
            {
                "name": "YAO Qing",
                "org": "Heart Center, Xuanwu Hospital, Capital Medical University, Beijing "
            },
            {
                "name": "XU Dong",
                "org": "Heart Center, Xuanwu Hospital, Capital Medical University, Beijing "
            },
            {
                "name": "SHANG Xue-bin",
                "org": "Heart Center, Xuanwu Hospital, Capital Medical University, Beijing "
            }
        ],
        "venue": "beijing medical journal",
        "keywords": [
            "Cardiac mass Cardiac surgery Diagnosis and treatment"
        ],
        "year": 2012
    },
    "rynAsAhU": {
        "id": "rynAsAhU",
        "title": "Relationship of Serum Ferritin,Oxidized Low Density Lipoprotein and Total Bilirubin in Patients with Coronary Heart Disease",
        "authors": [
            {
                "name": "Wang Yanling",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "Cui Wei",
                "org": "Department of Cardiology,The Second Hospital,Hebei Medical University"
            },
            {
                "name": "Hua Qi",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "Xu Dong",
                "org": "Department of Cardiology,Xuanwu Hospital,Capital Medical University"
            }
        ],
        "venue": "journal of capital medical university",
        "keywords": [
            "coronary heart disease",
            "serum ferritin",
            "oxidized low density lipoprotein",
            "coronary atherosclerosis",
            "total bilirubin"
        ],
        "year": 2008
    },
    "tuOpEY98": {
        "id": "tuOpEY98",
        "title": "Investigation of the timing for interventional therapy of simultaneous acute myocardial infarction and cerebral infarction",
        "authors": [
            {
                "name": "XIA Jing-gang",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HAO Heng-jian",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of interventional cardiology",
        "keywords": [
            "Brain infarction",
            "Interventional therapy",
            "Myocardial infarction"
        ],
        "year": 2010
    },
    "u03xXRHc": {
        "id": "u03xXRHc",
        "title": "Impact of prior cerebral infarction on in-hospital mortality in patients with acute myocardial infarction]",
        "authors": [
            {
                "name": "Wan Yun-gao",
                "org": "Department of Cardiology, Capital Medical University Xuanwu Hospital, Beijing, China."
            },
            {
                "name": "Xu Dong"
            },
            {
                "name": "Wang Hui-juan"
            },
            {
                "name": "Hua Qi"
            },
            {
                "name": "He Shi-da"
            },
            {
                "name": "Kong Qiang"
            },
            {
                "name": "Fan Zhen-xing"
            },
            {
                "name": "Liu Zhi"
            }
        ],
        "venue": "zhonghua nei ke za zhi",
        "keywords": [],
        "year": 2011
    },
    "nNQ8Qmoz": {
        "id": "nNQ8Qmoz",
        "title": "Clinic Analysis of 10 Cases of Infective Endocarditis",
        "authors": [
            {
                "name": "Xu Dong",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Yao Qing",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Zhang Kefeng",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Liu Yanhui",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Shang Xuebin",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Li Hongli",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Liu Fei",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Zhang Rui",
                "org": ".Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "journal of medical research",
        "keywords": [
            "Diagnosis",
            "Infective endocarditis",
            "Retrospective analysis",
            "Treatment"
        ],
        "year": 2011
    },
    "gCyCQoFx": {
        "id": "gCyCQoFx",
        "title": "Effects of L-carnitine on Ischemic-reperfusion Injury in Rabbit Cardiomyocytes in vivo",
        "authors": [
            {
                "name": "Xia Jinggang",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "Qu Yang",
                "org": "Department of Pathology,Beijing Chest Hospital"
            },
            {
                "name": "Hua Qi",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University"
            },
            {
                "name": "Xu Dong",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University"
            }
        ],
        "venue": "journal of capital medical university",
        "keywords": [
            "rabbit",
            "HSP70",
            "myocardial ischemia/reperfusion",
            "L-carnitine"
        ],
        "year": 2008
    },
    "JM70IanG": {
        "id": "JM70IanG",
        "title": "Increasing cardiopulmonary bypass flow volume improves outcome of patient with carotid stenosis undergoing coronary artery bypass grafting]",
        "authors": [
            {
                "name": "Xu Dong",
                "org": "Department of Heart, Xuanwu Hospital, Capital Medicine University, Beijing 100053, China."
            },
            {
                "name": "Liu Fei"
            },
            {
                "name": "Hua Yang"
            },
            {
                "name": "Zhang Ke-feng"
            },
            {
                "name": "Liu Yan-hui"
            },
            {
                "name": "Shang Xue-bin"
            },
            {
                "name": "Li Hong-li"
            },
            {
                "name": "Yao Qing"
            },
            {
                "name": "Li Xue-feng"
            },
            {
                "name": "Zhang Rui"
            },
            {
                "name": "Li Ya-qiong"
            }
        ],
        "venue": "zhonghua wai ke za zhi [chinese journal of surgery]",
        "keywords": [],
        "year": 2009
    },
    "U4ZG4eBs": {
        "id": "U4ZG4eBs",
        "title": "Non-specific clinical features and analysis of the cause of misdiagnosis of acute pulmonary embolism",
        "authors": [
            {
                "name": "YIN Chunlin",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "WEI Jiaping",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HAO Hengjian",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XIA Jinggang",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "FAN Zhenxing",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Ji",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": " Department of Cardiology,Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "journal of cardiovascular and pulmonary diseases",
        "keywords": [
            "Acute pulmonary embolism",
            "Clinical features",
            "Misdiagnosis"
        ],
        "year": 2012
    },
    "GxfE18xY": {
        "id": "GxfE18xY",
        "title": "The clinical effect of emergency and elective coronary artery bypass grafting",
        "authors": [
            {
                "name": "LIU Fei",
                "org": "Heart Center,Xuanwu Hospital Of Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": "Heart Center,Xuanwu Hospital Of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Ya-qiong",
                "org": "Heart Center,Xuanwu Hospital Of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "practical journal of clinical medicine",
        "keywords": [
            "Emergency",
            "Prognosis",
            "Coronary artery bypass grafting(CABG)"
        ],
        "year": 2009
    },
    "SoQAkuXg": {
        "id": "SoQAkuXg",
        "title": "Right ventricular and left atrial and left ventricular myxomas: report of a case.",
        "authors": [
            {
                "name": "Zhang Kefeng",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Xu Dong",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Shang Xuebin",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Liu Yanhui",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Li Hongli",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Liu Fei",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Yao Qing",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            },
            {
                "name": "Wang Xiaoliang",
                "org": "Xuanwu Hospital Capital Medical University(Capital Medical University,Xuanwu Hospital,Capital University of Medical Sciences),Beijing,China"
            }
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        "venue": "surgery today",
        "keywords": [
            "cardiac surgery",
            "myxoma",
            "surgical technique"
        ],
        "year": 2012
    },
    "ATGN2IKk": {
        "id": "ATGN2IKk",
        "title": "Acute ST-segment elevation myocardial infarction in the implementation of the emergency status of the green channel and its influencing factors",
        "authors": [
            {
                "name": "XIA Jinggang",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China"
            },
            {
                "name": "HAO Hengjian",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China"
            },
            {
                "name": "XU Dong",
                "org": "Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China"
            }
        ],
        "venue": "journal of clinical cardiology",
        "keywords": [
            "emergency the green channel",
            "myocardial infarction"
        ],
        "year": 2011
    },
    "KLULBVFa": {
        "id": "KLULBVFa",
        "title": "Application of Intra-aortic Balloon Pumping on Heart Failure in Coronary Artery Disease",
        "authors": [
            {
                "name": "Li Hong-li",
                "org": "Department of cardiac surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing  China"
            },
            {
                "name": "Xu Dong",
                "org": "Department of cardiac surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing  China"
            },
            {
                "name": "Shang Xue-bin",
                "org": "Department of cardiac surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing  China"
            },
            {
                "name": "Liu Yan-hui",
                "org": "Department of cardiac surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing  China"
            },
            {
                "name": "Liu fei",
                "org": "Department of cardiac surgery, Xuanwu Hospital of Capital University of Medical Science, Beijing  China"
            }
        ],
        "venue": "chinese journal of medicine",
        "keywords": [
            "Cardiogenic shock",
            "Intra-aortic balloon pump (IABP)",
            "Coronary heart disease"
        ],
        "year": 2006
    },
    "f0AyxIPA": {
        "id": "f0AyxIPA",
        "title": "Cardioprotective effect and mechanism of intensive lipid modulation on patients with coronary artery disease undergoing noncardiac surgery]",
        "authors": [
            {
                "name": "Xia Jing-gang",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China."
            },
            {
                "name": "Qu Yang",
                "org": "Deparment of Pathology, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China."
            },
            {
                "name": "Hu Shao-dong",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China."
            },
            {
                "name": "Xu Ji",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China."
            },
            {
                "name": "Yin Chun-lin",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China."
            },
            {
                "name": "Xu Dong",
                "org": "Department of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China."
            }
        ],
        "venue": "beijing da xue xue bao. yi xue ban = journal of peking university. health sciences",
        "keywords": [],
        "year": 2014
    },
    "5Ph84bb6": {
        "id": "5Ph84bb6",
        "title": "The investigation of tirofiban in patients with acute myocardial infarction after primary percutaneous coronary intervention",
        "authors": [
            {
                "name": "HU Shao-dong",
                "org": "Department of Cardiology,Xuanwu Hospital,Beijing "
            },
            {
                "name": "HAO Heng-jian",
                "org": "Department of Cardiology,Xuanwu Hospital,Beijing "
            },
            {
                "name": "XU Dong",
                "org": "Department of Cardiology,Xuanwu Hospital,Beijing "
            }
        ],
        "venue": "beijing medical journal",
        "keywords": [
            "Myocardial infarction Angioplasty Tirofiban"
        ],
        "year": 2011
    },
    "qR5uGg59": {
        "id": "qR5uGg59",
        "title": "Evaluation of Coronary Artery Bypass Grafts Lesion with 64-slice Multi-slice Spiral Computed Tomography and Risk Factor Analysis",
        "authors": [
            {
                "name": "Xu Dong",
                "org": ",Lin Yanhui.Heart Center,Xuanwu Hospial,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Ren Jie",
                "org": ",Lin Yanhui.Heart Center,Xuanwu Hospial,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Zhang Kefeng",
                "org": ",Lin Yanhui.Heart Center,Xuanwu Hospial,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Liu Fei",
                "org": ",Lin Yanhui.Heart Center,Xuanwu Hospial,Capital Medical University,Beijing ,China"
            },
            {
                "name": "Li Hongli",
                "org": ",Lin Yanhui.Heart Center,Xuanwu Hospial,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "journal of medical research",
        "keywords": [
            "Coronary artery bypass grafting",
            "computed tomography",
            "Multiple risk factors",
            "Multi-slice spiral"
        ],
        "year": 2010
    },
    "N24ikNWw": {
        "id": "N24ikNWw",
        "title": "The Diagnosis and Treatment of Patients With Prinzmetal's Variant Angina",
        "authors": [
            {
                "name": "YIN Chun-lin",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            },
            {
                "name": "WEI Jia-ping",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            },
            {
                "name": "HAO Heng-jian",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            },
            {
                "name": "XU Ji",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            },
            {
                "name": "XU Dong",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            },
            {
                "name": "FAN Zhen-xing",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            },
            {
                "name": "XIA Jing-gang",
                "org": ". Department of Cardiology,Xuanwu Hospital,Capital University of Medical Science,Beijing%%#%%#,China"
            }
        ],
        "venue": "chinese circulation journal",
        "keywords": [
            "Prinzmetal's variant angina",
            "Treatment",
            "Diagnostic assessment"
        ],
        "year": 2011
    },
    "Nd4mAbSv": {
        "id": "Nd4mAbSv",
        "title": "Fibrinolytic Therapy for Patients with Acute Myocardial Infarction in Recent 15 Years",
        "authors": [
            {
                "name": "CHEN Bing-pu",
                "org": "Purchase Center,Beijing Military Command General Hospital,Beijing ,China"
            },
            {
                "name": "XI Mei",
                "org": "Dept.of Pharmacy,Capital Medical University Affiliated Beijing Hospital of Traditional Chinese Medicine,Beijing ,China"
            },
            {
                "name": "WAN Yun-gao",
                "org": "Dept.of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WANG Hui-juan",
                "org": "Dept.of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "WEN Man-hua",
                "org": "Dept.of Pharmacy,Xuanwu Hospital of Capital Medical University,Beijing,China"
            },
            {
                "name": "XU Dong",
                "org": "Dept.of Cardiology,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "evaluation and analysis of drug-use in hospitals of china",
        "keywords": [
            "Fibrinolytic agents",
            "Acute myocardial infarction",
            "Coronary angioplasty"
        ],
        "year": 2010
    },
    "g9g1M66o": {
        "id": "g9g1M66o",
        "title": "Diagnosis and treatment of acute myocardial infarction with elevated ST-segment induced by left main coronary disease",
        "authors": [
            {
                "name": "XIA Jing-gang",
                "org": "Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "QU Yang",
                "org": "Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "YIN Chun-lin",
                "org": "Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "HAO Heng-jian",
                "org": "Xuanwu Hospital,Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": "Xuanwu Hospital,Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "journal of critical care in internal medicine",
        "keywords": [
            "Myocardial infarction Intra-aortic balloon pump Left main coronary artery Electrocardiogram"
        ],
        "year": 2012
    },
    "KbE6HbXh": {
        "id": "KbE6HbXh",
        "title": "Therapeutic effect of percutaneous coronary artery interventional procedures on complex coronary artery diseases",
        "authors": [
            {
                "name": "HU Shaodong",
                "org": ",et al.Department of Cardiology,Xuanwu Hospital Affiliated to Capital Medical University,Beijing ,China"
            },
            {
                "name": "HAO Hengjian",
                "org": ",et al.Department of Cardiology,Xuanwu Hospital Affiliated to Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": ",et al.Department of Cardiology,Xuanwu Hospital Affiliated to Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "hebei medical journal",
        "keywords": [
            "coronary artery disease",
            "radial artery",
            "percataneous coronary artery interventional therapy"
        ],
        "year": 2011
    },
    "HifSG112": {
        "id": "HifSG112",
        "title": "The protective effect of bisoprolol on elderly patients with silent ischemia in the perioperative phase of noncardiac surgery",
        "authors": [
            {
                "name": "XIA Jing-gang",
                "org": ". Center of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 10053, China"
            },
            {
                "name": "XU Dong",
                "org": ". Center of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing 10053, China"
            }
        ],
        "venue": "the journal of practical medicine",
        "keywords": [
            "Bisoprolol",
            "Myocardial ischemia",
            "Elderly patients"
        ],
        "year": 2009
    },
    "CgyrdTl5": {
        "id": "CgyrdTl5",
        "title": "Clinical outcomes of 80 patients after emergency coronary artery bypass grafting",
        "authors": [
            {
                "name": "LI Ya-qiong",
                "org": "Cardiology Center, XuanWu Hospital of Capital Medical University, Beijing "
            },
            {
                "name": "XU Dong",
                "org": "Cardiology Center, XuanWu Hospital of Capital Medical University, Beijing "
            },
            {
                "name": "SHANG Xue-bin",
                "org": "Cardiology Center, XuanWu Hospital of Capital Medical University, Beijing "
            }
        ],
        "venue": "beijing medical journal",
        "keywords": [
            "ECABG Acute coronary syndrome"
        ],
        "year": 2012
    },
    "0goDqfEn": {
        "id": "0goDqfEn",
        "title": "The Cerebral Blood Flow Changes in Patients With Carotid Artery Stenosis Undergoing Coronary Artery Bypass Grafting",
        "authors": [
            {
                "name": "XU Dong",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "LIU Fei",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "HUA Yang",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "LIU Yan-hui",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "LI Hong-li",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "YAO Qing",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "LI Xue-feng",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "ZHANG Rui",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            },
            {
                "name": "LI Ya-qiong",
                "org": ". Heart Center,Beijing Xuanwu Hospital,Capital Medical University,Beijing%%#%%#,China"
            }
        ],
        "venue": "chinese circulation journal",
        "keywords": [
            "Trans cranial doppler",
            "Cardiopulmonary bypass",
            "Carotid artery stenosis"
        ],
        "year": 2009
    },
    "zSlnyVm7": {
        "id": "zSlnyVm7",
        "title": "Effect of frequent idiopathic ventricular premature contractions from right ventricular outflow tract on structure of right ventricular outflow tract",
        "authors": [
            {
                "name": "KONG Qiang",
                "org": " Heart Center,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHI Li-sheng",
                "org": " Heart Center,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "CHEN Yu-jia",
                "org": " Heart Center,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "ZHANG Fan",
                "org": " Heart Center,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": " Heart Center,Xuanwu Hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "clinical focus",
        "keywords": [
            "catheter ablation",
            "ventricular outflow tract",
            "ventricular premature complexes"
        ],
        "year": 2012
    },
    "0gwkslUE": {
        "id": "0gwkslUE",
        "title": "A Preliminary Study on Acute Brain Death Model of Pig for Heart Transplantation",
        "authors": [
            {
                "name": "ZHANG Ke-feng",
                "org": "Department of Cardiac Surgery,Xuanwu Hospital,Capital University of Medical Sciences,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": "Department of Cardiac Surgery,Xuanwu Hospital,Capital University of Medical Sciences,Beijing ,China"
            },
            {
                "name": "ZANG Wang-fu",
                "org": "Department of Cardiac Surgery,Rui Jin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai ,China"
            }
        ],
        "venue": "acta laboratorium animalis scientia sinica",
        "keywords": [
            "Catecholamine",
            "Acute brain death",
            "Heart transplantation",
            "Pig",
            "Hemodynamics"
        ],
        "year": 2007
    },
    "qrTSEv96": {
        "id": "qrTSEv96",
        "title": "Application of Transcranial Doppler Monitoring in Aortic Dissection Surgical Procedure",
        "authors": [
            {
                "name": "ZHANG Ke-feng",
                "org": "Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,P.R.China"
            },
            {
                "name": "XU Dong",
                "org": "Heart Center,Xuanwu Hospital,Capital Medical University,Beijing ,P.R.China"
            },
            {
                "name": "HUA Yang",
                "org": "Department of Vascular Ultrasonography,Xuanwu Hospital,Capital Medical University,Beijing ,P.R.China"
            }
        ],
        "venue": "chinese journal of clinical thoracic and cardiovascular surgery",
        "keywords": [
            "Transcranial Doppler",
            "Selected cerebral perfusion",
            "Aortic dissection"
        ],
        "year": 2011
    },
    "NXfzNNbd": {
        "id": "NXfzNNbd",
        "title": "Surgical treatment in patients suffering from coronary artery disease with left ventricular dysfunction",
        "authors": [
            {
                "name": "ZHANG Ke-feng",
                "org": "Heart Center,Xuanwu hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "XU Dong",
                "org": "Heart Center,Xuanwu hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "SHANG Xue-bin",
                "org": "Heart Center,Xuanwu hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Yan-hui",
                "org": "Heart Center,Xuanwu hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LI Hong-li",
                "org": "Heart Center,Xuanwu hospital of Capital Medical University,Beijing ,China"
            },
            {
                "name": "LIU Fei",
                "org": "Heart Center,Xuanwu hospital of Capital Medical University,Beijing ,China"
            }
        ],
        "venue": "chinese journal of medicine",
        "keywords": [
            "coronary artery disease",
            "coronary artery bypass grafting",
            "left ventricular dysfunction"
        ],
        "year": 2008
    },
    "qJOJUKKQ": {
        "id": "qJOJUKKQ",
        "title": "The Correlation Analysis of Total Homocysteine Level and Methylene Tetrahydrofolate Reductase Gene Polymorphism With Other Risk Factors in Patients of Acute Coronary Syndrome",
        "authors": [
            {
                "name": "YIN Chun-lin"
            },
            {
                "name": "XU Dong"
            },
            {
                "name": "WEI Jia-ping"
            },
            {
                "name": "HAO Heng-jian"
            },
            {
                "name": "TAN Jing"
            },
            {
                "name": "GUO Li-juan"
            },
            {
                "name": "WANG Yan-ling"
            },
            {
                "name": "XIA Jing-gang"
            },
            {
                "name": "FAN Zhen-xing"
            },
            {
                "name": "XU Ji"
            }
        ],
        "venue": "chinese circulation journal",
        "keywords": [
            "Acute coronary syndrome",
            "Risk factor",
            "Homocysteine"
        ],
        "year": 2013
    },
    "3rkGtBkF": {
        "id": "3rkGtBkF",
        "title": "A preliminary feasibility and safety study of Tirofiban application of drug-eluting stent implantation in patients with non-cardiac surgery",
        "authors": [
            {
                "name": "XIA Jing-gang",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China."
            },
            {
                "name": "YIN Chun-lin",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China."
            },
            {
                "name": "QU Yang",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China."
            },
            {
                "name": "HAO Heng-jian",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China."
            },
            {
                "name": "XU Dong",
                "org": ".Center of Cadiology Medicine,Xuanwu Hospital,Capital Medical University,Beijing,,China."
            }
        ],
        "venue": "the journal of practical medicine",
        "keywords": [
            "Tirofiban",
            "stent thrombosis",
            "non-cardiac",
            "surgery"
        ],
        "year": 2011
    },
    "2o0Joc6m": {
        "id": "2o0Joc6m",
        "title": "Analysis of Diagnosis and Treatment of 8 Cases With Acute Cerebrovascular Disease Complicated With Pulmonary Embolism",
        "authors": [
            {
                "name": "XIA Jinggang",
                "org": ".Xuanwu Hospital,Capital Medical University,Beijing  China"
            },
            {
                "name": "XU Dong",
                "org": ".Xuanwu Hospital,Capital Medical University,Beijing  China"
            }
        ],
        "venue": "journal of internal intensive medicine",
        "keywords": [
            "Acute cerebral vascular disease Pulmonary embolism Clinical manifestation Diagnosis Treatment"
        ],
        "year": 2010
    },
    "VUBV6kdn": {
        "id": "VUBV6kdn",
        "title": "Correlation between serum level of hs-CRP at presentation and syncope in patients with acute pulmonary embolism",
        "authors": [
            {
                "name": "KONG Qiang",
                "org": ".Heart Center, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "WAN Yun-gao",
                "org": ".Heart Center, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "XU Dong",
                "org": ".Heart Center, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "QIN Jian",
                "org": ".Heart Center, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "Xia Jing-gang",
                "org": ".Heart Center, Xuanwu Hospital, Capital Medical University, Beijing , China"
            },
            {
                "name": "YIN Chun-lin",
                "org": ".Heart Center, Xuanwu Hospital, Capital Medical University, Beijing , China"
            }
        ],
        "venue": "the journal of practical medicine",
        "keywords": [
            "Pulmonary embolism",
            "Syncope",
            "hs C-reactive protein"
        ],
        "year": 2010
    },
    "v9CRKPWj": {
        "id": "v9CRKPWj",
        "title": "An Alternative Approach to ChIP-Seq Normalization Enables Detection of Genome-Wide Changes in Histone H3 Lysine 27 Trimethylation upon EZH2 Inhibition.",
        "abstract": "Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require modulation of chromatin structure. However, analysis of ChIP-seq data is challenging when the manipulation of a chromatin-modifying enzyme significantly affects global levels of histone post-translational modifications. For example, small molecule inhibition of the methyltransferase EZH2 reduces global levels of histone H3 lysine 27 trimethylation (H3K27me3). However, standard ChIP-seq normalization and analysis methods fail to detect a decrease upon EZH2 inhibitor treatment. We overcome this challenge by employing an alternative normalization approach that is based on the addition of Drosophila melanogaster chromatin and a D. melanogaster-specific antibody into standard ChIP reactions. Specifically, the use of an antibody that exclusively recognizes the D. melanogaster histone variant H2Av enables precipitation of D. melanogaster chromatin as a minor fraction of the total ChIP DNA. The D. melanogaster ChIP-seq tags are used to normalize the human ChIP-seq data from DMSO and EZH2 inhibitor-treated samples. Employing this strategy, a substantial reduction in H3K27me3 signal is now observed in ChIP-seq data from EZH2 inhibitor treated samples.",
        "keywords": "",
        "authors": [
            {
                "name": "Brian Egan",
                "org": "Active Motif Inc., Carlsbad, California, United States of America."
            },
            {
                "name": "Chih-Chi Yuan",
                "org": "Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America."
            },
            {
                "name": "Madeleine Lisa Craske",
                "org": "Active Motif Inc., Carlsbad, California, United States of America."
            },
            {
                "name": "Paul Labhart",
                "org": "Active Motif Inc., Carlsbad, California, United States of America."
            },
            {
                "name": "Gulfem D Guler",
                "org": "Department of Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America."
            },
            {
                "name": "David Arnott",
                "org": "Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America."
            },
            {
                "name": "Tobias M Maile",
                "org": "Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America."
            },
            {
                "name": "Jennifer Busby",
                "org": "Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America."
            },
            {
                "name": "Chisato Henry",
                "org": "Active Motif Inc., Carlsbad, California, United States of America."
            },
            {
                "name": "Theresa K Kelly",
                "org": "Active Motif Inc., Carlsbad, California, United States of America."
            },
            {
                "name": "Charles A Tindell",
                "org": "Department of Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America."
            },
            {
                "name": "Suchit Jhunjhunwala",
                "org": "Department of Bioinformatics, Genentech Inc., South San Francisco, California, United States of America."
            },
            {
                "name": "Feng Zhao",
                "org": "Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America."
            },
            {
                "name": "Charlie Hatton",
                "org": "Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America."
            },
            {
                "name": "Barbara M Bryant",
                "org": "Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America."
            },
            {
                "name": "Marie Classon",
                "org": "Department of Molecular Oncology, Genentech Inc., South San Francisco, California, United States of America."
            },
            {
                "name": "Patrick Trojer",
                "org": "Constellation Pharmaceuticals Inc., Cambridge, Massachusetts, United States of America."
            }
        ],
        "venue": "PloS one",
        "year": 2016
    },
    "iFTXVZEN": {
        "id": "iFTXVZEN",
        "title": "Abstract 5526: Inhibition of the histone methyl transferase EZH2 causes viability defects in multiple myeloma",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "shilpi arora",
                "org": ""
            },
            {
                "name": "vidya balasubramanian",
                "org": ""
            },
            {
                "name": "kaylyn williamson",
                "org": ""
            },
            {
                "name": "victor s gehling",
                "org": ""
            },
            {
                "name": "christopher g nasveschuk",
                "org": ""
            },
            {
                "name": "rishi vaswani",
                "org": ""
            },
            {
                "name": "jennifer busby",
                "org": ""
            },
            {
                "name": "shivani garapaty",
                "org": ""
            },
            {
                "name": "priya iyer",
                "org": ""
            },
            {
                "name": "feng zhao",
                "org": ""
            },
            {
                "name": "robert m campbell",
                "org": ""
            },
            {
                "name": "richard cummings",
                "org": ""
            },
            {
                "name": "james e audia",
                "org": ""
            },
            {
                "name": "j c harmange",
                "org": ""
            },
            {
                "name": "brian k albrecht",
                "org": ""
            },
            {
                "name": "andrew s cook",
                "org": ""
            },
            {
                "name": "les a dakin",
                "org": ""
            },
            {
                "name": "emmanuel normant",
                "org": ""
            },
            {
                "name": "patrick trojer",
                "org": ""
            }
        ],
        "venue": "Cancer Research",
        "year": 2014
    },
    "h7ydtoAU": {
        "id": "h7ydtoAU",
        "title": "Discovery, design, and synthesis of indole-based EZH2 inhibitors.",
        "abstract": "The discovery and optimization of a series of small molecule EZH2 inhibitors is described. Starting from dimethylpyridone HTS hit (2), a series of indole-based EZH2 inhibitors were identified. Biochemical potency and microsomal stability were optimized during these studies and afforded compound 22. This compound demonstrates nanomolar levels of biochemical potency (IC50=0.002 \u03bcM), cellular potency (EC50=0.080 \u03bcM), and afforded tumor regression when dosed (200 mpk SC BID) in an EZH2 dependent tumor xenograft model.",
        "keywords": [
            "EZH2",
            "Epigenetics",
            "Histone methyltransferase",
            "PRC2",
            "Pyridone"
        ],
        "authors": [
            {
                "name": "victor s gehling",
                "org": ""
            },
            {
                "name": "rishi g vaswani",
                "org": ""
            },
            {
                "name": "christopher g nasveschuk",
                "org": ""
            },
            {
                "name": "martin duplessis",
                "org": ""
            },
            {
                "name": "priyadarshini iyer",
                "org": ""
            },
            {
                "name": "srividya balasubramanian",
                "org": ""
            },
            {
                "name": "feng zhao",
                "org": ""
            },
            {
                "name": "andrew c good",
                "org": ""
            },
            {
                "name": "robert campbell",
                "org": ""
            },
            {
                "name": "christina lee",
                "org": ""
            },
            {
                "name": "les a dakin",
                "org": ""
            },
            {
                "name": "andrew s cook",
                "org": ""
            },
            {
                "name": "alexandre gagnon",
                "org": ""
            },
            {
                "name": "jeanchristophe harmange",
                "org": ""
            },
            {
                "name": "james e audia",
                "org": ""
            },
            {
                "name": "richard cummings",
                "org": ""
            },
            {
                "name": "emmanuel normant",
                "org": ""
            },
            {
                "name": "patrick trojer",
                "org": ""
            },
            {
                "name": "brian k albrecht",
                "org": ""
            }
        ],
        "venue": "Bioorganic & medicinal chemistry letters",
        "year": 2015
    },
    "7FpvVCHL": {
        "id": "7FpvVCHL",
        "title": "390 Inhibitors of EZH2 act synergistically with type 1 interferon to induce a potent interferon-stimulated gene response, triggering apoptosis in diffuse large B-cell lymphoma",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "barbara a bradley",
                "org": ""
            },
            {
                "name": "feng zhao",
                "org": ""
            },
            {
                "name": "c c yuan",
                "org": ""
            },
            {
                "name": "srividya balasubramanian",
                "org": ""
            },
            {
                "name": "priyadarshini iyer",
                "org": ""
            },
            {
                "name": "c hatton",
                "org": ""
            },
            {
                "name": "b bryant",
                "org": ""
            },
            {
                "name": "emmanuel normant",
                "org": ""
            },
            {
                "name": "patrick trojer",
                "org": ""
            }
        ],
        "venue": "European Journal of Cancer",
        "year": 2014
    },
    "al2KW8b6": {
        "id": "al2KW8b6",
        "title": "Discovery and Optimization of Tetramethylpiperidinyl Benzamides as Inhibitors of EZH2",
        "abstract": "",
        "keywords": [],
        "authors": [
            {
                "name": "louise bergeron",
                "org": ""
            },
            {
                "name": "feng zhao",
                "org": ""
            },
            {
                "name": "christina lee",
                "org": ""
            },
            {
                "name": "christopher g nasveschuk",
                "org": ""
            },
            {
                "name": "alexandre gagnon",
                "org": ""
            },
            {
                "name": "shivani garapatyrao",
                "org": ""
            },
            {
                "name": "srividya balasubramanian",
                "org": ""
            },
            {
                "name": "robert campbell",
                "org": ""
            },
            {
                "name": "richard cummings",
                "org": ""
            },
            {
                "name": "patrick trojer",
                "org": ""
            },
            {
                "name": "james e audia",
                "org": ""
            },
            {
                "name": "brian k albrecht",
                "org": ""
            },
            {
                "name": "jeanchristophe harmange",
                "org": ""
            }
        ],
        "venue": "ACS Medicinal Chemistry Letters",
        "year": 2014
    },
    "SSNnxxQm": {
        "id": "SSNnxxQm",
        "title": "Abstract B31: EZH2 suppresses the interferon-stimulated gene response in non-Hodgkin lymphoma",
        "abstract": "",
        "keywords": "",
        "authors": [
            {
                "name": "William D. Bradley",
                "org": ""
            },
            {
                "name": "Chih-Chi Yuan",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Feng Zhao",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Christina R. Lee",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Kaylyn Williamson",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Shilpi Arora",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Charlie Hatton",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Barbara M. Bryant",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            },
            {
                "name": "Patrick Trojer",
                "org": "Constellation Pharmaceuticals, Cambridge, MA."
            }
        ],
        "venue": "Cancer Research",
        "year": 2016
    },
    "MhtOdvAC": {
        "authors": [
            {
                "name": "C. Hu",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "L. Sun",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "L. Xiao",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "Y. Han",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "X. Fu",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "X. Xiong",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "X. Xu",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "Y. Liu",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "S. Yang",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "F. Liu",
                "org": "Department of Nephrology, Central South University, 2nd Xiangya Hospital"
            },
            {
                "name": "Y.S. Kanwar",
                "org": "Departments of Pathology and Medicine, Northwestern University"
            }
        ],
        "title": "Insights into the mechanisms involved in the expression and regulation of extracellular matrix proteins in diabetic nephropathy",
        "keywords": [
            "Diabetic nephropathy",
            "Extracellular matrix",
            "MTOR",
            "Notch",
            "TLRS and small GTPase",
            "WNT"
        ],
        "venue": "Current Medicinal Chemistry",
        "year": 2015,
        "id": "MhtOdvAC"
    },
    "QwajR1uQ": {
        "authors": [
            {
                "name": "Yong Zhang",
                "org": "Jiangxi Provincial Department of Information Center"
            },
            {
                "name": "Kai Yu",
                "org": "Henan Xinzheng Coal and Electric Co."
            },
            {
                "name": "Chen Chen",
                "org": "Shandong Zhengyuan Geographic Information Co., Ltd."
            },
            {
                "name": "Na Li",
                "org": "Shandong Zhengyuan Geographic Information Co., Ltd."
            }
        ],
        "title": "Design and implementation of the tax management system based on silverlight API for ArcGIS server",
        "abstract": "Tax management system based on geographical information technology has a good application prospect in tax management, which can achieve bidirectional cross monitoring between static land and dynamic taxpayer, and realize map monitoring and management of land tax. Then this paper realized land based tracking, monitoring, integrated management. According to the overall demand of tax management, this article described the design of tax management system simple, combining with the design, selecting representative function to realize and to provide reference tax system based on graphics.",
        "keywords": [
            "Analysis",
            "Early warning",
            "Geographic information",
            "Management",
            "Taxation"
        ],
        "venue": "Journal of Geomatics",
        "year": 2014,
        "id": "QwajR1uQ"
    },
    "1uskxQZt": {
        "authors": [
            {
                "name": "Jun Zhang",
                "org": ""
            },
            {
                "name": "Yi-Bing Zhang",
                "org": ""
            },
            {
                "name": "Min Wu",
                "org": ""
            },
            {
                "name": "Bing Wang",
                "org": ""
            },
            {
                "name": "Chen Chen",
                "org": ""
            },
            {
                "name": "Jian-Fang Gui",
                "org": ""
            }
        ],
        "title": "Fish MAVS is involved in RLR pathway-mediated IFN response",
        "keywords": [
            "Crucian carp carassius auratus",
            "IFN response",
            "MAVS",
            "MITA",
            "RLR signaling pathway"
        ],
        "venue": "Fish and Shellfish Immunology",
        "year": 2014,
        "id": "1uskxQZt"
    },
    "xNeBP05x": {
        "authors": [
            {
                "name": "Chen Chen",
                "org": "Department of Neurology, Institute of Neurology, Tianjin General Hospital"
            },
            {
                "name": "Peng Jiang",
                "org": "Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children"
            },
            {
                "name": "Haipeng Xue",
                "org": "Center for Regenerative Medicine, Department of Chemical Physiology, Scripps Research Institute"
            },
            {
                "name": "Suzanne E. Peterson",
                "org": "Center for Regenerative Medicine, Department of Chemical Physiology, Scripps Research Institute"
            },
            {
                "name": "Ha T. Tran",
                "org": "Center for Regenerative Medicine, Department of Chemical Physiology, Scripps Research Institute"
            },
            {
                "name": "Anna E. McCann",
                "org": "Department of Biology, University of Washington"
            },
            {
                "name": "Mana M. Parast",
                "org": "Department of Pathology, University of California"
            },
            {
                "name": "Shenglan Li",
                "org": "Center for Stem Cell and Regenerative Medicine, Brown Foundation Institute of Molecular Medicine, University of Texas Health"
            },
            {
                "name": "David E. Pleasure",
                "org": "Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children"
            },
            {
                "name": "Louise C. Laurent",
                "org": "Center for Regenerative Medicine, Department of Chemical Physiology, Scripps Research Institute"
            },
            {
                "name": "Jeanne F. Loring",
                "org": "Center for Regenerative Medicine, Department of Chemical Physiology, Scripps Research Institute"
            },
            {
                "name": "Ying Liu",
                "org": "Center for Regenerative Medicine, Department of Chemical Physiology, Scripps Research Institute"
            },
            {
                "name": "Wenbin Deng",
                "org": "Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children"
            }
        ],
        "title": "Role of astroglia in down's syndrome revealed by patient-derived human-induced pluripotent stem cells",
        "abstract": "Down's syndrome (DS), caused by trisomy of human chromosome 21, is the most common genetic cause of intellectual disability. Here we use induced pluripotent stem cells (iPSCs) derived from DS patients to identify a role for astrocytes in DS pathogenesis. DS astroglia exhibit higher levels of reactive oxygen species and lower levels of synaptogenic molecules. Astrocyte-conditioned medium collected from DS astroglia causes toxicity to neurons, and fails to promote neuronal ion channel maturation and synapse formation. Transplantation studies show that DS astroglia do not promote neurogenesis of endogenous neural stem cells in vivo. We also observed abnormal gene expression profiles from DS astroglia. Finally, we show that the FDA-approved antibiotic drug, minocycline, partially corrects the pathological phenotypes of DS astroglia by specifically modulating the expression of S100B, GFAP, inducible nitric oxide synthase, and thrombospondins 1 and 2 in DS astroglia. Our studies shed light on the pathogenesis and possible treatment of DS by targeting astrocytes with a clinically available drug. \u00a9 2014 Macmillan Publishers Limited. All rights reserved.",
        "keywords": [
            ""
        ],
        "venue": "Nature Communications",
        "year": 2014,
        "id": "xNeBP05x"
    },
    "CgQRxEqW": {
        "authors": [
            {
                "name": "Xiaozhi Rong",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Chen Chen",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Pin Zhou",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Yumei Zhou",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Yun Li",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Ling Lu",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Yunzhang Liu",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Jianfeng Zhou",
                "org": "Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China"
            },
            {
                "name": "Cunming Duan",
                "org": "Department of Molecular, Cellular, and Developmental Biology, University of Michigan"
            }
        ],
        "title": "R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/\u03b2-catenin signaling in zebrafish embryos",
        "abstract": "The Wnt/\u03b2-catenin or canonical Wnt signaling pathway plays fundamental roles in early development and in maintaining adult tissue homeostasis. R-spondin 3 (Rspo3) is a secreted protein that has been implicated in activating the Wnt/\u03b2-catenin signaling in amphibians and mammals. Here we report that zebrafish Rspo3 plays a negative role in regulating the zygotic Wnt/\u03b2-catenin signaling. Zebrafish Rspo3 has a unique domain structure. It contains a third furin-like (FU3) domain. This FU3 is present in other four ray-finned fish species studied but not in elephant shark. In zebrafish, rspo3 mRNA is maternally deposited and has a ubiquitous expression in early embryonic stages. After 12 hpf, its expression becomes tissue-specific. Forced expression of rspo3 promotes dorsoanterior patterning and increases the expression of dorsal and anterior marker genes. Knockdown of rspo3 increases ventral-posterior development and stimulates ventral and posterior marker genes expression. Forced expression of rspo3 abolishes exogenous Wnt3a action and reduces the endogenous Wnt signaling activity. Knockdown of rspo3 results in increased Wnt/\u03b2-catenin signaling activity. Further analyses indicate that Rspo3 does not promote maternal Wnt signaling. Human RSPO3 has similar action when tested in zebrafish embryos. These results suggest that Rspo3 regulates dorsoventral and anteroposterior patterning by negatively regulating the zygotic Wnt/\u03b2-catenin signaling in zebrafish embryos. \u00a9 2014 Rong et al.",
        "keywords": [
            ""
        ],
        "venue": "PLoS ONE",
        "year": 2014,
        "id": "CgQRxEqW"
    },
    "q9vqaoWr": {
        "authors": [
            {
                "name": "Xianlei Wang",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Ling Lu",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Yun Li",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Mingyu Li",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Chen Chen",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Qiang Feng",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Chunyang Zhang",
                "org": "Laboratory of Molecular Medicine"
            },
            {
                "name": "Cunming Duan",
                "org": "Dept. of Molecular, Cellular, and Developmental Biology"
            }
        ],
        "title": "Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish",
        "abstract": "Insulin-like growth factor binding proteins (IGFBPs) are high-affinity binding partners for IGFs and play important roles in modulating IGF activities. In this study, we have identified and characterized two functional IGFBP-6 genes in zebrafish. Structural, phylogenetic, and comparative genomic analyses indicate that they are co-orthologs of the human IGFBP-6 gene. To gain insight into how the duplicated genes may have evolved through partitioning of ancestral functions, gene expression and functional studies were carried out. In adult fish, IGFBP-6a mRNA was most abundantly expressed in the muscle. The levels of IGFBP-6a mRNA in nonmuscle tissues were very low or barely detectable. In comparison, the levels of IGFBP-6b mRNA were high in the brain, heart, and muscle, but very low or undetectable in other adult tissues. During embryogenesis, the IGFBP-6a mRNA levels were relatively low. The IGFBP-6b mRNA levels were low during the initial 48 h. They became significantly higher at 72 and 96 h postfertilization. Overexpression of zebrafish IGFBP-6a and IGFBP-6b caused a similar degree of reduction in body size and developmental rate. No notable effects were observed on cell fate or patterning in these transgenic fish. These data suggest that the duplicated igfbp-6 genes encode two functionally similar proteins, but they have evolved distinct spatial and temporal expression patterns. These findings are consistent with the notion of an additional gene duplication event in teleost fish and have provided novel insight into the structural and functional evolution of the IGFBP gene family. Copyright \u00a9 2009 the American Physiological Society.",
        "keywords": [
            "Binding protein",
            "Embryo",
            "Gene duplication",
            "Growth",
            "Insulin-like growth factor"
        ],
        "venue": "American Journal of Physiology - Regulatory Integrative and Comparative Physiology",
        "year": 2009,
        "id": "q9vqaoWr"
    },
    "1KHPm6RH": {
        "authors": [
            {
                "name": "Punhal Lashari",
                "org": "Department of Fresh Water Biology and Fisheries, University of Sindh Pakistan"
            },
            {
                "name": "Muhammad Younis Laghari",
                "org": "Department of Fresh Water Biology and Fisheries, University of Sindh Pakistan"
            },
            {
                "name": "Peng Xu",
                "org": "Centre for Applied Aquatic Genomics, Chinese Academy of Fishery Sciences"
            },
            {
                "name": "Zixia Zhao",
                "org": "Centre for Applied Aquatic Genomics, Chinese Academy of Fishery Sciences"
            },
            {
                "name": "Li Jiang",
                "org": "Centre for Applied Aquatic Genomics, Chinese Academy of Fishery Sciences"
            },
            {
                "name": "Naeem Tariq Narejo",
                "org": "Department of Fresh Water Biology and Fisheries, University of Sindh Pakistan"
            },
            {
                "name": "Yulin Deng",
                "org": "School of Life Sciences, Beijing Institute of Technology"
            },
            {
                "name": "Xiaowen Sun",
                "org": "Centre for Applied Aquatic Genomics, Chinese Academy of Fishery Sciences"
            },
            {
                "name": "Yan Zhang",
                "org": "Centre for Applied Aquatic Genomics, Chinese Academy of Fishery Sciences"
            }
        ],
        "title": "Complete mitochondrial genome of the Freshwater Catfish Rita rita (Siluriformes, Bagridae)",
        "abstract": "The complete mitochondrial genome of Catfish, Rita rita, was isolated by LA PCR (TakaRa LAtaq, Dalian, China); and sequenced by Sangers method to obtain the complete mitochondrial genome, which is listed Critically Endangered and Red Listed species. The complete mitogenome was 16,449 bp in length and contains 13 typical vertebrate protein-coding genes, 2 rRNA and 22 tRNA genes. The whole genome base composition was estimated to be 33.40% A, 27.43% C, 14.26% G and 24.89% T. The complete mitochondrial genome of catfish, Rita rita provides the basis for genetic breeding and conservation studies.",
        "keywords": [
            "Endangered species",
            "mitochondrial genome",
            "Rita rita",
            "river Indus"
        ],
        "venue": "Mitochondrial DNA",
        "year": 2015,
        "id": "1KHPm6RH"
    },
    "Zm1pboSa": {
        "id": "Zm1pboSa",
        "title": "EVALUATION OF LEFT VENTRICULAR LONG-AXIS SYSTOLIC FUNCTION IN ESSENTIAL HYPERTENSIVE PATIENTS WITH NOMAL GEOMETRY USING REAL-TIME TRIPLANE AUTOMATED FUNCTION IMAGING",
        "authors": [
            {
                "name": "Pan Meishu",
                "org": "Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "Zhang Di",
                "org": "Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "Guo Shenglan",
                "org": "Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "Wu Ji",
                "org": "Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            }
        ],
        "venue": "journal of guangxi medical university",
        "keywords": [
            "real-time triplane",
            "left ventricular long-axis systolic function",
            "automated function imaging",
            "hypertention"
        ],
        "year": 2012
    },
    "aGwqJJ1Q": {
        "id": "aGwqJJ1Q",
        "title": "Assessment of left atrial function in patients with rheumatic mitral stenosis and sinus rhythm before and after percutaneous balloon mitral valvuloplasty by real time three-dimensional echocardiography",
        "authors": [
            {
                "name": "DENG Yan",
                "org": "Department of Ultrasound,First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "GUO Sheng-lan",
                "org": "Department of Ultrasound,First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "ZHANG Li",
                "org": "Department of Ultrasound,First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "WU Ji",
                "org": "Department of Ultrasound,First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "ZHANG Di",
                "org": "Department of Ultrasound,First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            }
        ],
        "venue": "journal of china clinic medical imaging",
        "keywords": [
            "Rheumatic heart disease",
            "Mitral valve stenosis",
            "three-dimensional",
            "Echocardiography"
        ],
        "year": 2012
    },
    "wY8cBl6y": {
        "id": "wY8cBl6y",
        "title": "Real-time three-dimensional echocardiography assessment of intra-left ventricular systolic synchronism in patients with chronic heart failure",
        "authors": [
            {
                "name": "CAO Rui",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "WU Ji",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "GUO Sheng-lan",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "ZHANG Di",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "LUO Shuai-wei",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "DENG Yan",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            }
        ],
        "venue": "chinese journal of medical imaging technology",
        "keywords": [
            "Heart failure",
            "Echocardiography",
            "left",
            "Ventricular function"
        ],
        "year": 2011
    },
    "4fdUL93w": {
        "id": "4fdUL93w",
        "title": "EFFECT OF AMBULATORY BLOOD PRESSURE PROFILE ON REGIONAL LEFT VENTRICULAR SYSTOLIC FUNCTION IN HYPERTENSIVE PATIENTS BY STRAIN RATE IMAGING",
        "authors": [
            {
                "name": "Guan Zhiqiang",
                "org": "Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning China"
            },
            {
                "name": "Zhang Di",
                "org": "Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning China"
            }
        ],
        "venue": "journal of guangxi medical university",
        "keywords": [
            "left ventricular systolic function",
            "hypertension",
            "ambulatory blood pressure profile",
            "strain rate imaging"
        ],
        "year": 2010
    },
    "3vo1IL2m": {
        "id": "3vo1IL2m",
        "title": "A Comparative Study of Cardiac Function in Patients with Coronary Heart Disease and Hypertension by Strain Rate Imaging",
        "authors": [
            {
                "name": "WANG Qing-rong",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "ZHANG Di",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "GUAN Zhi-qiang",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "GUO Sheng-lan",
                "org": "Department of Ultrasonography,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            }
        ],
        "venue": "guangxi medical journal",
        "keywords": [
            "Strain rate imaging",
            "Left ventricular function",
            "Coronary heart disease",
            "Hypertension"
        ],
        "year": 2011
    },
    "0zxdoNig": {
        "id": "0zxdoNig",
        "title": "Effect of ST-segment Changes after Percutaneous Coronary Intervention on Left Ventricular Systolic Function among Patients with Acute Myocardial Infraction",
        "authors": [
            {
                "name": "ZHANG Fang",
                "org": "1 Department of ECG,"
            },
            {
                "name": "HE Tao",
                "org": "1 Department of ECG,"
            },
            {
                "name": "GUO Sheng-lan",
                "org": "2 Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "ZHANG Di",
                "org": "2 Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "GUAN Zhi-qiang",
                "org": "2 Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "WANG Qing-rong",
                "org": "2 Department of Ultrasound,the First Affiliated Hospital of Guangxi Medical University,Nanning ,China"
            }
        ],
        "venue": "guangxi medical journal",
        "keywords": [
            "ST segment",
            "Acute myocardial infraction",
            "Percutaneous coronary intervention",
            "Left ventricular systolic function"
        ],
        "year": 2012
    },
    "IGYZbeUU": {
        "id": "IGYZbeUU",
        "title": "Assessment of left atrial function in patients with hypertrophic cardiomyopathy by strain rate",
        "authors": [
            {
                "name": "XU Li-fang",
                "org": "Department of Ultrasound,the First Hospital Affiliated of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "WU Ji",
                "org": "Department of Ultrasound,the First Hospital Affiliated of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "GUO Sheng-lan",
                "org": "Department of Ultrasound,the First Hospital Affiliated of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "ZHANG Di",
                "org": "Department of Ultrasound,the First Hospital Affiliated of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "LUO Shuai-wei",
                "org": "Department of Ultrasound,the First Hospital Affiliated of Guangxi Medical University,Nanning ,China"
            },
            {
                "name": "HUANG Xi-yu",
                "org": "Department of Ultrasound,the First Hospital Affiliated of Guangxi Medical University,Nanning ,China"
            }
        ],
        "venue": "journal of minimally invasive medicine",
        "keywords": [
            "Left atrial function",
            "Strain rate",
            "Echocardiography",
            "Hypertrophic cardiomyopathy"
        ],
        "year": 2011
    },
    "VdDtJTJr": {
        "id": "VdDtJTJr",
        "title": "Left atrial asynchrony and mechanical function in patients with mitral stenosis before and immediately after percutaneous balloon mitral valvuloplasty: a real time three-dimensional echocardiography study.",
        "authors": [
            {
                "name": "Deng Yan",
                "org": "Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China."
            },
            {
                "name": "Guo Sheng-lan"
            },
            {
                "name": "Su Hong-yue"
            },
            {
                "name": "Wang Qian"
            },
            {
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            },
            {
                "name": "Wu Ji"
            },
            {
                "name": "Zhang Di"
            }
        ],
        "venue": "echocardiography (mount kisco, n.y.)",
        "keywords": [
            "asynchrony",
            "atrial fibrillation",
            "left atrium",
            "real time three-dimensional echocardiography",
            "rheumatic mitral stenosis"
        ],
        "year": 2015
    },
    "4SIOl4qD": {
        "id": "4SIOl4qD",
        "title": "Research Status of Prenatal Ultrasonic Diagnosis in Fetal Malformation",
        "authors": [
            {
                "name": "HUANG Qiao-yan",
                "org": "Deparment of Ultrasound,the Chinese and Western Orthopaedics Hospital of Guigang,Guigang ,China"
            },
            {
                "name": "ZHANG Di",
                "org": "Deparment of Ultrasound,the First Affiliated Hospital of Guangxi University,Nanning ,China"
            }
        ],
        "venue": "medical recapitulate",
        "keywords": [
            "Prenatal",
            "Fetal malformation",
            "Ultrasonic diagnosis"
        ],
        "year": 2010
    },
    "JaQ3wiFz": {
        "id": "JaQ3wiFz",
        "title": "Evaluation of left ventricular remodeling and function in dilated cardiomyopathy by echocardiography",
        "authors": [
            {
                "name": "WU Ji",
                "org": " Department of Echocardiography, First Affiliated Hospital, Guangxi Medical University, Nanning , China"
            },
            {
                "name": "LI Zhi-xian",
                "org": " Depar